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Conserved domains on  [gi|487749071|ref|WP_001831062|]
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MULTISPECIES: nickel transporter permease [Staphylococcus]

Protein Classification

ABC transporter permease( domain architecture ID 11439449)

ABC transporter permease is the transmembrane (TM) subunit in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which generally binds a type 2 PBP; similar to the permease subunit of ABC-type dipeptide/oligopeptide/nickel transport systems

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
2-265 3.55e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 258.50  E-value: 3.55e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071   2 KFKLSKKNTIFFIFTVYIICLIVLQFIINDEAAYQVHLSNSFEPMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLL 81
Cdd:COG1173   11 RLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  82 FTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQ 161
Cdd:COG1173   91 IALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLRER 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 162 SYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMII 241
Cdd:COG1173  171 EYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLAL 250
                        250       260
                 ....*....|....*....|....
gi 487749071 242 APASLISGTILIFNLTGDAVRDRL 265
Cdd:COG1173  251 FPGLAIVLTVLAFNLLGDGLRDAL 274
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
2-265 3.55e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 258.50  E-value: 3.55e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071   2 KFKLSKKNTIFFIFTVYIICLIVLQFIINDEAAYQVHLSNSFEPMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLL 81
Cdd:COG1173   11 RLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  82 FTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQ 161
Cdd:COG1173   91 IALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLRER 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 162 SYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMII 241
Cdd:COG1173  171 EYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLAL 250
                        250       260
                 ....*....|....*....|....
gi 487749071 242 APASLISGTILIFNLTGDAVRDRL 265
Cdd:COG1173  251 FPGLAIVLTVLAFNLLGDGLRDAL 274
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
36-265 6.54e-66

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 206.47  E-value: 6.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071   36 QVHLSNSFEPMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSI 115
Cdd:TIGR02790  28 AQNLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIGLLIGGLAGYIGGRVDEAIMRVCDVFLSF 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  116 PEFVIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMI 195
Cdd:TIGR02790 108 PTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAARTSGASHWQIIRRHILPNILSPIIVLAT 187
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  196 VDFGKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:TIGR02790 188 LDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAILISVMAFNLLGDALRDHL 257
nikC PRK10417
nickel transporter permease NikC; Provisional
37-265 1.10e-57

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 185.64  E-value: 1.10e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  37 VHLSNSFEPMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIP 116
Cdd:PRK10417  34 IDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFP 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 117 EFVIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIV 196
Cdd:PRK10417 114 TSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATL 193
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487749071 197 DFGKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:PRK10417 194 DIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLLMFWPGLALFISVMAFNLLGDALRDHL 262
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
87-232 4.92e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 74.24  E-value: 4.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  87 GVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALASFF--------HPSLWNLVIAITIIKWMNYTRVTRGIVNTE 158
Cdd:cd06261   19 GLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFgvllgwgiLPGLGLPALILALLLIAPFARLIRRAALES 98
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487749071 159 MNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFLGLGAqPPSPEWGAMLQAGREF 232
Cdd:cd06261   99 IPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGPGTGLLLIFAILF 171
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
87-265 3.49e-15

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 71.95  E-value: 3.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071   87 GVPLGLLAG-YKKGWIDTIIMRIIDIGLSIPEFVIMIALASFFHPSLWNL----VIAITIIKWMNYTRVTRGIVNTEMNQ 161
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHgilpAIILALLGWAGYARLIRRAALRSLPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  162 SYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFL----GLGAQPPSPEWGAMLQagrefitshp 237
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYP---------- 150
                         170       180
                  ....*....|....*....|....*...
gi 487749071  238 iMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:pfam00528 151 -EIQGPVLAAALILLLLNLLVDILQRLL 177
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
2-265 3.55e-86

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 258.50  E-value: 3.55e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071   2 KFKLSKKNTIFFIFTVYIICLIVLQFIINDEAAYQVHLSNSFEPMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLL 81
Cdd:COG1173   11 RLRRNPLAVIGLVILLLLVLLALFAPLLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  82 FTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQ 161
Cdd:COG1173   91 IALVIGVLLGLLAGYFGGWVDAVLMRLVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLRER 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 162 SYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMII 241
Cdd:COG1173  171 EYVEAARALGASPLRIIFRHILPNVLPPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLAL 250
                        250       260
                 ....*....|....*....|....
gi 487749071 242 APASLISGTILIFNLTGDAVRDRL 265
Cdd:COG1173  251 FPGLAIVLTVLAFNLLGDGLRDAL 274
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
36-265 6.54e-66

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 206.47  E-value: 6.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071   36 QVHLSNSFEPMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSI 115
Cdd:TIGR02790  28 AQNLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIGLLIGGLAGYIGGRVDEAIMRVCDVFLSF 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  116 PEFVIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMI 195
Cdd:TIGR02790 108 PTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAARTSGASHWQIIRRHILPNILSPIIVLAT 187
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  196 VDFGKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:TIGR02790 188 LDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAILISVMAFNLLGDALRDHL 257
nikC PRK10417
nickel transporter permease NikC; Provisional
37-265 1.10e-57

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 185.64  E-value: 1.10e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  37 VHLSNSFEPMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIP 116
Cdd:PRK10417  34 IDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFP 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 117 EFVIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIV 196
Cdd:PRK10417 114 TSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATL 193
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487749071 197 DFGKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:PRK10417 194 DIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLLMFWPGLALFISVMAFNLLGDALRDHL 262
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
39-265 9.39e-55

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 179.24  E-value: 9.39e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  39 LSNSFEPMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEF 118
Cdd:PRK09881  63 LTARLLPPSAAHWFGTDEVGRDLFSRVLVGSQQSILAGLVVVAIAGMIGSLLGCLSGVLGGRADAIIMRIMDIMLSIPSL 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 119 VIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDF 198
Cdd:PRK09881 143 VLTMALAAALGPSLFNAMLAIAIVRIPFYVRLARGQALVVRQYTYVQAAKTFGASRWHLISWHILRNSLPPLIVQASLDI 222
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487749071 199 GKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:PRK09881 223 GSAILMAATLGFIGLGAQQPSAEWGAMVANGRNYVLDQWWYCAFPGAAILLTAVGFNLFGDGIRDLL 289
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
47-265 2.54e-50

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 167.65  E-value: 2.54e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  47 SMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALAS 126
Cdd:PRK10913  76 SWAHILGTDDVGRDVLSRLMYGARLSLLVGCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVA 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 127 FFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYIS 206
Cdd:PRK10913 156 IFGPSIVNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINILPNCLAPLIVQASLGFSNAILDMA 235
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 487749071 207 SLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:PRK10913 236 ALGFLGMGAQPPTPEWGTMLSDVLQFAQSAWWVVTFPGLAILLTVLAFNLMGDGLRDAL 294
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
47-265 3.44e-49

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 164.90  E-value: 3.44e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  47 SMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALAS 126
Cdd:PRK15082  77 SLQHWFGVDSLGRDIFSRILVGARISLAAGFFSVAIGAAIGTVLGLLAGYYEGWWDRIIMRICDVLFAFPGILLAIAVVA 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 127 FFHPSLWNLVIAITIIKWMNYTRVTRGivNTEM--NQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILY 204
Cdd:PRK15082 157 ILGSGMANVIIAVAIFSIPAFARLVRG--NTLVlkQQTYIESARSIGASDWTILLRHILPGTVSSIVVYFTMRIGTSIIT 234
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487749071 205 ISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:PRK15082 235 AASLSFLGLGAQPPTPEWGAMLNEARADMVIAPHVALFPSLAIFLTVLAFNLLGDGLRDAL 295
SapC COG4171
ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];
11-269 7.90e-43

ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];


Pssm-ID: 443331 [Multi-domain]  Cd Length: 296  Bit Score: 148.04  E-value: 7.90e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  11 IFFIFTVYIICLIVLqFIINDEAAYQVHLSNSFEPM-SMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVP 89
Cdd:COG4171   37 LFLILLALFGPLLAP-YSPDQQFIGALLLPPSWDDNgDVSFFLGTDDLGRDILSRLLYGARYTFGSALLVVLAAAIIGGI 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  90 LGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQF 169
Cdd:COG4171  116 IGILAGMSRGLKSSILNHLLDTLLSIPSLLLAIIIVALLGPGLENAMLAITLALLPQFIHAIYQAVHQELKKEYVLAARL 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 170 FNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISG 249
Cdd:COG4171  196 DGASNWQLLRYSILPNILEVLVTELTRALSIAILDISALGFLGLGAQLPSPEWGAMLGDSLELIYLAPWTVILPGLAIMF 275
                        250       260
                 ....*....|....*....|
gi 487749071 250 TILIFNLTGDAVRdRLLEQR 269
Cdd:COG4171  276 SVLIVNLVGDGLR-RALNKG 294
PRK15406 PRK15406
oligopeptide ABC transporter permease OppC; Provisional
46-265 7.89e-35

oligopeptide ABC transporter permease OppC; Provisional


Pssm-ID: 185304 [Multi-domain]  Cd Length: 302  Bit Score: 127.26  E-value: 7.89e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  46 MSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALA 125
Cdd:PRK15406  78 MESGHYFGTDSSGRDLLVRVAIGGRISLMVGVAAALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEILNSFPFMFFVILLV 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 126 SFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYI 205
Cdd:PRK15406 158 TFFGQNILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIEAAQVGGVSTRGIVLRHIVPNVLGVVVVYASLLVPSMILFE 237
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 206 SSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:PRK15406 238 SFLSFLGLGTQEPLSSWGALLSDGANSMEVSPWLLLFPAGFLVVTLFCFNFIGDGLRDAL 297
PRK15111 PRK15111
peptide ABC transporter permease SapC;
52-262 9.94e-33

peptide ABC transporter permease SapC;


Pssm-ID: 185066 [Multi-domain]  Cd Length: 296  Bit Score: 121.73  E-value: 9.94e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  52 LGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALASFFHPS 131
Cdd:PRK15111  78 LGTDDLGRDVLSRLLSGAAPTVGGAFVVTLAATLCGLVLGVFAGATHGLRSAVLNHILDTLLSIPSLLLAIIVVAFAGPS 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 132 LWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFL 211
Cdd:PRK15111 158 LSHAMFAVWLALLPRMVRSIYSAVHDELEKEYVIAARLDGASTLNILWYAVLPNITAGLVTEITRALSMAILDIAALGFL 237
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 487749071 212 GLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASLISGTILIFNLTGDAVR 262
Cdd:PRK15111 238 DLGAQLPSPEWGAMLGDSLELIYVAPWTVMLPGAAIMLSVLLVNLLGDGIR 288
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
45-263 2.70e-32

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 121.41  E-value: 2.70e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  45 PMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPE-FVIMIa 123
Cdd:COG4239  116 PPSAENWLGTDDQGRDVLARLIYGFRISVLFGLALTVISSVIGVAAGAVQGYFGGRVDLLFQRFIEIWSSMPElYLLII- 194
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 124 LASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIIL 203
Cdd:COG4239  195 LSSIFQPSFWLLLGILLLFGWMGLVGVVRAEFLRARNLEYVRAARALGVSDRRIMFRHILPNAMVATLTFLPFILSGAIT 274
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 204 YISSLSFLGLGAQPPSPEWGAMLQAGREFITShPIMIIAPASLISGTILIFNLTGDAVRD 263
Cdd:COG4239  275 TLTSLDFLGFGLPPGSPSLGELLAQGKNNLQA-PWLGLSAFVVLALMLSLLVFIGEAVRD 333
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
45-263 1.88e-26

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 105.84  E-value: 1.88e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  45 PMSMNHLLGTDDYGRDLFSRLVVGSRATLFVTLLTLLFTVVVGVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIAL 124
Cdd:PRK15021 116 PPSRQNWLGTDANGGDVLARILYGTRISVLFGLMLTLCSSVMGVLAGALQGYYGGKVDLWGQRFIEVWSGMPTLFLIILL 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 125 ASFFHPSLWNLVIAITIIKWMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILY 204
Cdd:PRK15021 196 SSVVQPNFWWLLAITVLFGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMVATLTFLPFILCSSITT 275
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071 205 ISSLSFLGLGAQPPSPEWGAMLQAGREFITSHPIMIIAPASL-ISGTILIFnlTGDAVRD 263
Cdd:PRK15021 276 LTSLDFLGFGLPLGSPSLGELLLQGKNNLQAPWLGITAFLSVaILLSLLIF--IGEAVRD 333
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
87-232 4.92e-16

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 74.24  E-value: 4.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  87 GVPLGLLAGYKKGWIDTIIMRIIDIGLSIPEFVIMIALASFF--------HPSLWNLVIAITIIKWMNYTRVTRGIVNTE 158
Cdd:cd06261   19 GLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFgvllgwgiLPGLGLPALILALLLIAPFARLIRRAALES 98
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487749071 159 MNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFLGLGAqPPSPEWGAMLQAGREF 232
Cdd:cd06261   99 IPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGPGTGLLLIFAILF 171
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
87-265 3.49e-15

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 71.95  E-value: 3.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071   87 GVPLGLLAG-YKKGWIDTIIMRIIDIGLSIPEFVIMIALASFFHPSLWNL----VIAITIIKWMNYTRVTRGIVNTEMNQ 161
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHgilpAIILALLGWAGYARLIRRAALRSLPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  162 SYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKIILYISSLSFL----GLGAQPPSPEWGAMLQagrefitshp 237
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYP---------- 150
                         170       180
                  ....*....|....*....|....*...
gi 487749071  238 iMIIAPASLISGTILIFNLTGDAVRDRL 265
Cdd:pfam00528 151 -EIQGPVLAAALILLLLNLLVDILQRLL 177
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
87-202 2.17e-11

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 63.16  E-value: 2.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  87 GVPLGLLAGYKKG-WIDTIIMRIIDIGLSIPEFVI-------------------MIALASFFHPSLWNLV---IAITIIK 143
Cdd:COG0601  113 GIPLGILAALRRGsWLDRLITVLALLGISIPSFWLglllillfavklgwlpvsgRVSPWEDFLDALRHLIlpaLTLALGS 192
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 487749071 144 WMNYTRVTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFGKII 202
Cdd:COG0601  193 LAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNALIPVVTVLGLQLGGLL 251
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
87-199 2.82e-04

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 41.29  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  87 GVPLGLLAGYKKgWIDTIIMRIIDIGLSIPEFVIMIALASFFHPSLWNLVIAITIIK-WMNYTRVTRGIVNTemNQSYIQ 165
Cdd:COG0600   81 GVPLGLLLGLSR-LLRRLLDPLLVFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAfFPILLNTAAGVRSV--DPELLE 157
                         90       100       110
                 ....*....|....*....|....*....|....
gi 487749071 166 MAQFFNVSTLNILFKHLLPKVLPSIFVIMIVDFG 199
Cdd:COG0600  158 LARSLGASRWQILRKVVLPAALPYIFTGLRIALG 191
oppB PRK09471
oligopeptide ABC transporter permease OppB;
87-190 1.15e-03

oligopeptide ABC transporter permease OppB;


Pssm-ID: 181886 [Multi-domain]  Cd Length: 306  Bit Score: 39.66  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749071  87 GVPLGLLAGYKKG-WIDTIIMRIIDIGLSIPEFVIMIALASFFHPSL-------WN---------LVIAITIIKWMNYTR 149
Cdd:PRK09471 112 GVSAGVIAALKQNtKWDYTVMGFAMTGVVIPSFVVAPLLVLIFAITLhwlpgggWNggalkfmilPMVALSLAYIASIAR 191
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 487749071 150 VTRGIVNTEMNQSYIQMAQFFNVSTLNILFKHLL-PKVLPSI 190
Cdd:PRK09471 192 ITRGSMIEVLHSNFIRTARAKGLPMRRIILRHALkPALLPVL 233
pstA PRK11268
phosphate ABC transporter permease PstA;
87-142 1.23e-03

phosphate ABC transporter permease PstA;


Pssm-ID: 183065 [Multi-domain]  Cd Length: 295  Bit Score: 39.67  E-value: 1.23e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487749071  87 GVPLGLLAGY------KKGWIDTIIMRIIDIGLSIPE-----FVIMIALASFFHPSLWNLVIAITII 142
Cdd:PRK11268  97 GTPLGIMAGIylaeygRKSWLAEVIRFINDILLSAPSivvglFVYTIVVAQMEHFSGWAGVIALALL 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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