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Conserved domains on  [gi|487749481|ref|WP_001831450|]
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MULTISPECIES: sucrose-specific PTS transporter subunit IIBC [Staphylococcus]

Protein Classification

PTS sucrose transporter subunit IIBC( domain architecture ID 11493431)

PTS sucrose transporter subunit IIBC is the fused IIB and IIC components of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) that catalyzes the phosphorylation of incoming sucrose substrate concomitant with its translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS-II-BC-sucr TIGR01996
PTS system, sucrose-specific IIBC component; This model represents the fused enzyme II B and C ...
 3-459 0e+00

PTS system, sucrose-specific IIBC component; This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).


:

Pssm-ID: 131051  Cd Length: 461  Bit Score: 656.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481    3 YKKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSGTVNKVFNELEKITG 82
Cdd:TIGR01996   2 YQQVAKEILELLGGKDNIVSVAHCATRLRLVLKDESKIDKKAIENLDGVKGTFFNSGQYQIIIGTGVVNKVYDEIVKLTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   83 KEASTTSEVKDKSSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAKDLFydGKSIIDVHSQFSGLADMINIF 162
Cdd:TIGR01996  82 LSESSTSEQKAEAAKKMNPFQRFARTLSDIFVPIIPAIVATGLLMGLNGMLTAFGLF--GLSGVSVAPIPEGLAEMINVF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  163 ANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFPKALEEGKAiphWDVFGLHINEVGYQGQVLPMLVA 242
Cdd:TIGR01996 160 TSTAFAFLPILIGFSAAKRFGGNPYLGAVIGLIMVHPSLPNAYGVAAGTATGKA---WNIFGLHIPVVGYQGTVLPVLVA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  243 TYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYAPIVIT 322
Cdd:TIGR01996 237 VWILAKIEKFLRKVVPNALDLLLTPFLTLLITGFLTLLVIGPIGRWVGDVLTDGLQWLYDLPGGLGGLLFGGLYSLIVIT 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  323 GMHHSFIAVETTLIADaTKTGGSFIFPIATMSNIAQGGAALAAFFIIKqNKKLKGVASAAGISALLGITEPAMFGVNLKL 402
Cdd:TIGR01996 317 GIHHSFHAIETQLLAN-TKTGGNFLFPIASMANVAQGGAALAVFFKTK-DKKLKGLAIPSGLSALLGITEPAIFGVNLRY 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 487749481  403 RYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFISINPTHAGWLHYLIGMLIAF 459
Cdd:TIGR01996 395 RKPFIAALIGGAIGGAYVVLFHVAATAYGLTGIPGFLSILPSGINLLHYIVGMLIAF 451
 
Name Accession Description Interval E-value
PTS-II-BC-sucr TIGR01996
PTS system, sucrose-specific IIBC component; This model represents the fused enzyme II B and C ...
 3-459 0e+00

PTS system, sucrose-specific IIBC component; This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).


Pssm-ID: 131051  Cd Length: 461  Bit Score: 656.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481    3 YKKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSGTVNKVFNELEKITG 82
Cdd:TIGR01996   2 YQQVAKEILELLGGKDNIVSVAHCATRLRLVLKDESKIDKKAIENLDGVKGTFFNSGQYQIIIGTGVVNKVYDEIVKLTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   83 KEASTTSEVKDKSSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAKDLFydGKSIIDVHSQFSGLADMINIF 162
Cdd:TIGR01996  82 LSESSTSEQKAEAAKKMNPFQRFARTLSDIFVPIIPAIVATGLLMGLNGMLTAFGLF--GLSGVSVAPIPEGLAEMINVF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  163 ANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFPKALEEGKAiphWDVFGLHINEVGYQGQVLPMLVA 242
Cdd:TIGR01996 160 TSTAFAFLPILIGFSAAKRFGGNPYLGAVIGLIMVHPSLPNAYGVAAGTATGKA---WNIFGLHIPVVGYQGTVLPVLVA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  243 TYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYAPIVIT 322
Cdd:TIGR01996 237 VWILAKIEKFLRKVVPNALDLLLTPFLTLLITGFLTLLVIGPIGRWVGDVLTDGLQWLYDLPGGLGGLLFGGLYSLIVIT 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  323 GMHHSFIAVETTLIADaTKTGGSFIFPIATMSNIAQGGAALAAFFIIKqNKKLKGVASAAGISALLGITEPAMFGVNLKL 402
Cdd:TIGR01996 317 GIHHSFHAIETQLLAN-TKTGGNFLFPIASMANVAQGGAALAVFFKTK-DKKLKGLAIPSGLSALLGITEPAIFGVNLRY 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 487749481  403 RYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFISINPTHAGWLHYLIGMLIAF 459
Cdd:TIGR01996 395 RKPFIAALIGGAIGGAYVVLFHVAATAYGLTGIPGFLSILPSGINLLHYIVGMLIAF 451
PtsG1 COG1263
Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific ...
 95-459 3.49e-114

Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism];


Pssm-ID: 440875 [Multi-domain]  Cd Length: 463  Bit Score: 344.23  E-value: 3.49e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  95 SSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAKDLFYDGksiidvhSQFSGLADMINIFANAPFTLLPILI 174
Cdd:COG1263    1 AKKKKNPLFRFLQKIGGIFMPPIPVLPAAGLLLGLGALLTNPGLLGEG-------SFLSGTYQILNAAGDAVFYFLPLLF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 175 GFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFPKAleegkaipHWDVFGLHINeVGYQGQVLPMLVATYILATIEKWLR 254
Cdd:COG1263   74 AIGAAKGFGGNPALAAVIGYLLVHPTLLNAYAVAGG--------YISFLGIPTL-IGYQGGVFPGILAGWLAAYLEKFLK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 255 KVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYAPIVITGMHHSFIAVETT 334
Cdd:COG1263  145 KKLPDALGFFFVPILTLLIMVPLALLVIGPIWPPIGNGIAAGLGWIYGLAGAIGGFIYGFLYRLLVPTGLHHGLNPIFWF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 335 LIADatkTGGSFIFPIATMSNIAQGGAALAAFFIIKQNKKLKGVASAAGISALL-GITEPAMFGVNLKLRYPFIGAVAGS 413
Cdd:COG1263  225 LLGG---TGDDGLFPILAAAMFGQPGAALAVYLKAKPNKKVKGLAISAALTAFLtGITEPAEFGFNLVAPKLFIAHAIGG 301

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 487749481 414 GIGAAYISFFKVKAIALGTAGLPGFISI-NPTHAGWLHYLIGMLIAF 459
Cdd:COG1263  302 GLGGAIAGLLGVKAFSFGVGGLIDFPSIlNPGATNLLLYLIGLVIAF 348
PRK11007 PRK11007
PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional
 4-480 9.05e-113

PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional


Pssm-ID: 182896  Cd Length: 473  Bit Score: 340.90  E-value: 9.05e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   4 KKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSgTVNKVFNELEKITGK 83
Cdd:PRK11007   7 QQDIDRLIELVGGRENIATVSHCITRLRFVLNDPANADPKEIEQLPMVKGCFTNAGQFQVVIGT-EVGDYYKALIATTGQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  84 EASTTSEVKDKSSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFtaKDL-FYDGKSIIDVHSQFSGLADMINIF 162
Cdd:PRK11007  86 AEVDKEQAKKAARQNMKWHERLISHFAEIFFPLLPALISGGLILGFRNVI--GDIpMSDGQTLAQMYPFWQTIYDFLWLI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 163 ANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFpkaleeGKAIPH-WDvFGLH-INEVGYQGQVLPML 240
Cdd:PRK11007 164 GEAIFFYLPVGICWSAVKKMGGTPILGIVLGVTLVSPQLMNAYLL------GQQLPEvWD-FGLFsIEKVGYQAQVIPAL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 241 VATYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGywlsDGLTWLYEFG-----GAIGGLIFGLL 315
Cdd:PRK11007 237 LAGLALGFIETRLKRIVPDYLYLVVVPVCSLILAVFLAHALIGPFGRMIG----DGVAFAVKALmtgsfAPIGAALFGFL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 316 YAPIVITGMHHSFIAVETTLIADatkTGGSFIFPIATMSNIAQGGAALAAFFIIKQNKKLKgVASAAGISALLGITEPAM 395
Cdd:PRK11007 313 YAPLVITGVHQTTLAIDLQMIQS---MGGTPVWPLIALSNIAQASAVVGIIIISRKHNERE-ISVPAAISAYLGVTEPAM 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 396 FGVNLKLRYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFISINPTHagWLHYLIGMLIAFVVSVVVTLVLSRRKTN 475
Cdd:PRK11007 389 YGINLKYRFPMLCAMIGSALAGLICGLNGVMANGIGVGGLPGILSIQPQY--WQVYALAMLVAIVVPIVLTSFIYKRKER 466


                 ....*
gi 487749481 476 KTVVE 480
Cdd:PRK11007 467 LGTLD 471
PTS_EIIC pfam02378
Phosphotransferase system, EIIC; The bacterial phosphoenolpyruvate: sugar phosphotransferase ...
 110-407 1.55e-55

Phosphotransferase system, EIIC; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.


Pssm-ID: 367061  Cd Length: 315  Bit Score: 187.55  E-value: 1.55e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  110 SDIFVPIIPAIVAGGLLMGLNNIFTAKDLFYDGKSIIDvhsqfSGLADMINIFANAPFTLLPILIGFSAAKRF-GGNPYL 188
Cdd:pfam02378   1 GDGFMPPIPLLIAGGILLGLGNLPNDTTGLPAGGFTGD-----SPLAEILKQAGSAAFGILPILFAIGIAYGLaGGDGVA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  189 GAALGMILVHPGLMSAYDFPKALEEGKAipHWDVFGLHINEVGYQGQVLPMLVATYILATIEKWLRKVIPTVLDNLLTPL 268
Cdd:pfam02378  76 GAAGLIGLLSFNLAAAISVALTAAGLSG--GGNILGIGLGATGVFGAIIPGLLAAYLYNRFEKNITIKLPDSLPFFVGKR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  269 LSIFITAFITFLFVGPVTRQLGYWLSDGLT----WLYEFGGAIGGLIFGLLYAPIVITGMHHSFIAVETTLIADATKTGG 344
Cdd:pfam02378 154 FVPIITGFVTLLVIGPVLGLIWPAIQGGLNalglLLIIAGGILGGLIFGFLERLLWPFGLHGAFIAIFWFLPIGGSNPIA 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487749481  345 SFI------------FPIATMSNIAQGGAALAAFFIIKQNKKLKGVASAAGISALLGITEPAMFGVNLKLRYPFI 407
Cdd:pfam02378 234 NQQaygagaahiltgGFDVMFGGPGATLALYAAAFLFKKSKVKKLLGSAALTPFLFGITEPLEFGFPFVLNPPFF 308
PTS_IIB_glc cd00212
PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: ...
 7-82 2.37e-28

PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation


Pssm-ID: 238130 [Multi-domain]  Cd Length: 78  Bit Score: 107.23  E-value: 2.37e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487749481   7 AEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSGtVNKVFNELEKITG 82
Cdd:cd00212    4 AKDILEALGGKENIVSLDHCATRLRLTVKDESKVDEAALKKLGGVKGVVKNGGQYQVIIGPG-VADVYKEAIKLLG 78
 
Name Accession Description Interval E-value
PTS-II-BC-sucr TIGR01996
PTS system, sucrose-specific IIBC component; This model represents the fused enzyme II B and C ...
 3-459 0e+00

PTS system, sucrose-specific IIBC component; This model represents the fused enzyme II B and C components of the sucrose-specific PTS sugar transporter system. Sucrose is converted to sucrose-6-phosphate in the process of translocation into the cell. Some of these transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci, Streptococci, Lactococci, Lactobacilli, etc. which contain their own A domain as a C-terminal fusion. This family is closely related to the trehalose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively).


Pssm-ID: 131051  Cd Length: 461  Bit Score: 656.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481    3 YKKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSGTVNKVFNELEKITG 82
Cdd:TIGR01996   2 YQQVAKEILELLGGKDNIVSVAHCATRLRLVLKDESKIDKKAIENLDGVKGTFFNSGQYQIIIGTGVVNKVYDEIVKLTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   83 KEASTTSEVKDKSSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAKDLFydGKSIIDVHSQFSGLADMINIF 162
Cdd:TIGR01996  82 LSESSTSEQKAEAAKKMNPFQRFARTLSDIFVPIIPAIVATGLLMGLNGMLTAFGLF--GLSGVSVAPIPEGLAEMINVF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  163 ANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFPKALEEGKAiphWDVFGLHINEVGYQGQVLPMLVA 242
Cdd:TIGR01996 160 TSTAFAFLPILIGFSAAKRFGGNPYLGAVIGLIMVHPSLPNAYGVAAGTATGKA---WNIFGLHIPVVGYQGTVLPVLVA 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  243 TYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYAPIVIT 322
Cdd:TIGR01996 237 VWILAKIEKFLRKVVPNALDLLLTPFLTLLITGFLTLLVIGPIGRWVGDVLTDGLQWLYDLPGGLGGLLFGGLYSLIVIT 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  323 GMHHSFIAVETTLIADaTKTGGSFIFPIATMSNIAQGGAALAAFFIIKqNKKLKGVASAAGISALLGITEPAMFGVNLKL 402
Cdd:TIGR01996 317 GIHHSFHAIETQLLAN-TKTGGNFLFPIASMANVAQGGAALAVFFKTK-DKKLKGLAIPSGLSALLGITEPAIFGVNLRY 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 487749481  403 RYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFISINPTHAGWLHYLIGMLIAF 459
Cdd:TIGR01996 395 RKPFIAALIGGAIGGAYVVLFHVAATAYGLTGIPGFLSILPSGINLLHYIVGMLIAF 451
PTS-IIBC-Tre TIGR01992
PTS system, trehalose-specific IIBC component; This model represents the fused enzyme II B and ...
 4-458 1.74e-179

PTS system, trehalose-specific IIBC component; This model represents the fused enzyme II B and C components of the trehalose-specific PTS sugar transporter system. Trehalose is converted to trehalose-6-phosphate in the process of translocation into the cell. These transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). The exceptions to this rule are Staphylococci and Streptococci which contain their own A domain as a C-terminal fusion. This family is closely related to the sucrose transporting PTS IIBC enzymes and the B and C domains of each are described by subfamily-domain level TIGRFAMs models (TIGR00826 and TIGR00852, respectively). In E. coli, B. subtilis and P. fluorescens the presence of this gene is associated with the presence of trehalase which degrades T6P to glucose and glucose-6-P. Trehalose may also be transported (in Salmonella) via the mannose PTS or galactose permease systems, or (in Sinorhizobium, Thermococcus and Sulfolobus, for instance) by ABC transporters.


Pssm-ID: 273916  Cd Length: 462  Bit Score: 510.81  E-value: 1.74e-179
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481    4 KKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSGTVNKVFNELEKITGK 83
Cdd:TIGR01992   1 RKDAKAILEAIGGKENIEAATHCVTRLRFVLKDPSKVDVKALEQIDLVKGSFTNAGQFQVVIGPGTVDKVYAALIAETGI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   84 EASTTSEVKDKSSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAKDLFYDGKSIIDVHSQFSGLADMINIFA 163
Cdd:TIGR01992  81 AEVSKEEVKKAAAKNMNPLQRLIKLLADIFIPILPAIITAGLLMGINNLLGAKGMSFGGQTLVEVYPQWAGIYNFINLIA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  164 NAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFPKALEEGkAIPHWDVFG-LHINEVGYQGQVLPMLVA 242
Cdd:TIGR01992 161 ETAFHFLPALIGWSAVKKFGGSPILGIVLGLMLVHPQLLNAYLYGQALAEG-NIPVWDLFGfFEIQKVGYQGQVLPALLA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  243 TYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYAPIVIT 322
Cdd:TIGR01992 240 GYVLAVIEKWLRKRVPDAIQLLVVPPVSLLVTGFLAHAIIGPIGRLIGNGITSGVTALFTSAAWLGGAIFGLLYAPLVIT 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  323 GMHHSFIAVETTLIADatkTGGSFIFPIATMSNIAQGGAALAAFFIIKqNKKLKGVASAAGISALLGITEPAMFGVNLKL 402
Cdd:TIGR01992 320 GLHHMFLAVDLQLIGS---LGGTFLWPMIALSNIAQGSAALGIIFMSR-NEKEKGLSLTSAISAYLGVTEPAMFGVNLKY 395

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 487749481  403 RYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFISINPTHagWLHYLIGMLIA 458
Cdd:TIGR01992 396 KFPFIAAMIGSGLAGLLSGLNGVLANSIGVGGLPGFISIQPQY--WPVFAIGMAIA 449
PtsG1 COG1263
Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific ...
 95-459 3.49e-114

Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism];


Pssm-ID: 440875 [Multi-domain]  Cd Length: 463  Bit Score: 344.23  E-value: 3.49e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  95 SSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAKDLFYDGksiidvhSQFSGLADMINIFANAPFTLLPILI 174
Cdd:COG1263    1 AKKKKNPLFRFLQKIGGIFMPPIPVLPAAGLLLGLGALLTNPGLLGEG-------SFLSGTYQILNAAGDAVFYFLPLLF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 175 GFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFPKAleegkaipHWDVFGLHINeVGYQGQVLPMLVATYILATIEKWLR 254
Cdd:COG1263   74 AIGAAKGFGGNPALAAVIGYLLVHPTLLNAYAVAGG--------YISFLGIPTL-IGYQGGVFPGILAGWLAAYLEKFLK 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 255 KVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYAPIVITGMHHSFIAVETT 334
Cdd:COG1263  145 KKLPDALGFFFVPILTLLIMVPLALLVIGPIWPPIGNGIAAGLGWIYGLAGAIGGFIYGFLYRLLVPTGLHHGLNPIFWF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 335 LIADatkTGGSFIFPIATMSNIAQGGAALAAFFIIKQNKKLKGVASAAGISALL-GITEPAMFGVNLKLRYPFIGAVAGS 413
Cdd:COG1263  225 LLGG---TGDDGLFPILAAAMFGQPGAALAVYLKAKPNKKVKGLAISAALTAFLtGITEPAEFGFNLVAPKLFIAHAIGG 301

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 487749481 414 GIGAAYISFFKVKAIALGTAGLPGFISI-NPTHAGWLHYLIGMLIAF 459
Cdd:COG1263  302 GLGGAIAGLLGVKAFSFGVGGLIDFPSIlNPGATNLLLYLIGLVIAF 348
PTS-II-ABC-beta TIGR01995
PTS system, beta-glucoside-specific IIABC component; This model represents a family of PTS ...
 3-459 3.89e-114

PTS system, beta-glucoside-specific IIABC component; This model represents a family of PTS enzyme II proteins in which all three domains are found in the same polypeptide chain and which appear to have a broad specificity for beta-glucosides including salicin (beta-D-glucose-1-salicylate) and arbutin (Hydroquinone-O-beta-D-glucopyranoside). These are distinct from the closely related sucrose-specific and trehalose-specific PTS transporters.


Pssm-ID: 273919 [Multi-domain]  Cd Length: 610  Bit Score: 348.96  E-value: 3.89e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481    3 YKKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSgTVNKVFNELEKITG 82
Cdd:TIGR01995   1 YQDLAKAIIENVGGKENIESVTHCATRLRFTLKDDAKADTEKLKKISGVITVVKSGGQYQVVIGN-DVNDVYQALMDVLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   83 KEastTSEVKDKSSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAkdlfydgKSIIDVHSQfsgLADMINIF 162
Cdd:TIGR01995  80 LD---DQAEDDDSKGKKSILNKLIDLISGVFTPLLPALAGAGLLKAVLTLLTM-------TGLISADSQ---TYQILNAM 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  163 ANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFPKALEegkaiphwdVFGLHINEVGYQGQVLPMLVA 242
Cdd:TIGR01995 147 GDAVFYFLPILLAITAAKRFKVNPYLAAAIGAALLHPTLVAMVGSGKPVT---------FFGIPVTLMSYSSSVIPVILA 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  243 TYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYAPIVIT 322
Cdd:TIGR01995 218 VWLMSYVEKFLKKVIPGALKNFLTPLLVMLITVPLTLLIIGPLGNYAGEGISSGILFLYEVSPWLAGALLAALWPVLVMF 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  323 GMHHSFIAVETTLIadATKTGGSFIFPIATMSNIAQGGAALAAFFIIKqNKKLKGVASAAGISALLGITEPAMFGVNLKL 402
Cdd:TIGR01995 298 GLHWAMIPIVINNI--ATQGFDPLILPASLAANFAQGGAALAVMLRTK-NKKLKALAGSATISALFGITEPAIYGVNLPL 374

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 487749481  403 RYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFIS-INP-THAGWLHYLIGMLIAF 459
Cdd:TIGR01995 375 KKPFYAAMIGGAVGGAIIGIGSVKAFTAFAPGLLGLPMfINPsDGANFISALIAIVISF 433
PRK11007 PRK11007
PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional
 4-480 9.05e-113

PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional


Pssm-ID: 182896  Cd Length: 473  Bit Score: 340.90  E-value: 9.05e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   4 KKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSgTVNKVFNELEKITGK 83
Cdd:PRK11007   7 QQDIDRLIELVGGRENIATVSHCITRLRFVLNDPANADPKEIEQLPMVKGCFTNAGQFQVVIGT-EVGDYYKALIATTGQ 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  84 EASTTSEVKDKSSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFtaKDL-FYDGKSIIDVHSQFSGLADMINIF 162
Cdd:PRK11007  86 AEVDKEQAKKAARQNMKWHERLISHFAEIFFPLLPALISGGLILGFRNVI--GDIpMSDGQTLAQMYPFWQTIYDFLWLI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 163 ANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYDFpkaleeGKAIPH-WDvFGLH-INEVGYQGQVLPML 240
Cdd:PRK11007 164 GEAIFFYLPVGICWSAVKKMGGTPILGIVLGVTLVSPQLMNAYLL------GQQLPEvWD-FGLFsIEKVGYQAQVIPAL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 241 VATYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGywlsDGLTWLYEFG-----GAIGGLIFGLL 315
Cdd:PRK11007 237 LAGLALGFIETRLKRIVPDYLYLVVVPVCSLILAVFLAHALIGPFGRMIG----DGVAFAVKALmtgsfAPIGAALFGFL 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 316 YAPIVITGMHHSFIAVETTLIADatkTGGSFIFPIATMSNIAQGGAALAAFFIIKQNKKLKgVASAAGISALLGITEPAM 395
Cdd:PRK11007 313 YAPLVITGVHQTTLAIDLQMIQS---MGGTPVWPLIALSNIAQASAVVGIIIISRKHNERE-ISVPAAISAYLGVTEPAM 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 396 FGVNLKLRYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFISINPTHagWLHYLIGMLIAFVVSVVVTLVLSRRKTN 475
Cdd:PRK11007 389 YGINLKYRFPMLCAMIGSALAGLICGLNGVMANGIGVGGLPGILSIQPQY--WQVYALAMLVAIVVPIVLTSFIYKRKER 466


                 ....*
gi 487749481 476 KTVVE 480
Cdd:PRK11007 467 LGTLD 471
pts-Glc TIGR00852
PTS system, maltose and glucose-specific subfamily, IIC component; The PTS Glucose-Glucoside ...
 163-457 9.07e-81

PTS system, maltose and glucose-specific subfamily, IIC component; The PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the E. coli PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. This model is specific for the IIC domain of the Glc family PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273299  Cd Length: 289  Bit Score: 252.24  E-value: 9.07e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  163 ANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYdfpkaleeGKAIPHW-DVFGLHINEVGYQGQVLPMLV 241
Cdd:TIGR00852   1 GSAAFFFLPLLFAIGAAKGFGGNPYLGAALAGILVHPVLNNAM--------GVGAQAVgNFFGFEIAKVGYTGVVGPIIV 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  242 ATYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYW-LSDGLTWLYEFGGAIGGLIFGLLYAPIV 320
Cdd:TIGR00852  73 GAIALALHERFLDKKLPDVLGFFLGPRFVVIIAGFVAILLIGPLGRVWPPVgISALLHWLYSAGGALGGAIFGFLYRLLV 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  321 ITGMHHSFIAVETTLIADATKTGGSFIFPIATMSNIAQGGAALAAFFIIKqNKKLKGVASAAGISALLGITEPAMFGVNL 400
Cdd:TIGR00852 153 PTGLHHIFYAIFIQLIAGGTVIGGGQVIPGDALANMAQGGAALAVFFTAG-DAKFKSIGLPAAFSAGLGITEPAMYGVAL 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 487749481  401 KLRYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFISINPTHAG-WLHYLIGMLI 457
Cdd:TIGR00852 232 RERRPFVAGLIGSALLTAFLTGITEPLEFLFLFGAPGLYSIHAVLAGsIFTVAIGMGI 289
PRK09824 PRK09824
PTS system beta-glucoside-specific transporter subunits IIABC; Provisional
 1-459 6.65e-71

PTS system beta-glucoside-specific transporter subunits IIABC; Provisional


Pssm-ID: 236627 [Multi-domain]  Cd Length: 627  Bit Score: 236.92  E-value: 6.65e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   1 MSYKKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSgTVNKVFNELEKI 80
Cdd:PRK09824   1 MEYTELAREIVAGVGGADNIVSLMHCATRLRFKLKDNSKAQAEVLKKNPGVIMVVESGGQFQVVIGN-HVADVFLAVNSV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  81 TG--KEASTTSEVKDKSskhmNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAkdlfydgksiIDVHSQFSGLADM 158
Cdd:PRK09824  80 AGlgEKAQQAPENDKKG----NLLNRFIDVISGIFTPLIGVMAATGILKGMLALALT----------FGWTTEQSGTYKI 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 159 INIFANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMSAYDfpkALEEGKAiPHWDVFGLHINEVGYQGQVLP 238
Cdd:PRK09824 146 LFAASDALFFFFPIILGYTAGKKFGGNPFTAMVIGGALVHPLMIAAFE---AGQKADA-LGLDFLGIPVTLLNYSSSVIP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 239 MLVATYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYAP 318
Cdd:PRK09824 222 IIFSAWLCSILERRLNAWLPSAIKNFFTPLLCLMVIVPLTFLLIGPLATWLSELLAAGYQWLYQAVPAFAGAVMGAFWQV 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 319 IVITGMHHSFIAVettLIADATKTGGSFIFPIATMSNIAQGGAALAAFFIIKqNKKLKGVASAAGISALLGITEPAMFGV 398
Cdd:PRK09824 302 FVIFGLHWGLVPL---MINNLTVLGHDTMLPLLMPAVMAQVGAALGVFLCTR-DAQKKVVAGSAFLAGLFGITEPAVYGV 377

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487749481 399 NLKLRYPFIGAVAGSGIGAAYISFFKVKAIALGTAGLPGFISINP---THAGWLHYLIGMLIAF 459
Cdd:PRK09824 378 NLPLKRPFIFGCISGALGAAIIGYAQTKVYSFGLPSIFTFMQTIPptgIDFTVWASVIGTVIAI 441
PRK09796 PRK09796
PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional
 1-435 2.50e-59

PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional


Pssm-ID: 182081  Cd Length: 472  Bit Score: 202.33  E-value: 2.50e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   1 MSYKKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSgTVNKVFNELEKI 80
Cdd:PRK09796   3 KNYAALARSVIAALGGVDNISAVTHCMTRLRFVIKDDALIDSPTLKTIPGVLGVVRSDNQCQVIIGN-TVSQAFQEVVSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  81 TGKEASTTSEVKDKSSKHMNPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFTAKDLFYDGKSIIDVhsqfsgladmIN 160
Cdd:PRK09796  82 LPGDMQPAQPVGKPKLTLRRIGAGILDALIGTMSPLIPAIIGGSMVKLLAMILEMSGVLTKGSPTLTI----------LN 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 161 IFANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVHPGLMsayDFPKALEEGKaipHWDVFGLHINEVGYQGQVLPML 240
Cdd:PRK09796 152 VIGDGAFFFLPLMVAASAAIKFKTNMSLAIAIAGVLVHPSFI---ELMAKAAQGE---HVEFALIPVTAVKYTYTVIPAL 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 241 VATYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPvtrqLGYWLSDGLTWL-YEFGGAIGGL---IFGLLY 316
Cdd:PRK09796 226 VMTWCLSYIERWVDRITPAVTKNFLKPMLIVLIAAPLAILLIGP----IGIWIGSAISALvYTIHGYLGWLsvaIMGALW 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 317 APIVITGMHHSFIAVETTLIADATKTGgsFIFPIATMSNIAQGGAALAAFFIIKqNKKLKGVASAAGISALL-GITEPAM 395
Cdd:PRK09796 302 PLLVMTGMHRVFTPTIIQTIAETGKEG--MVMPSEIGANLSLGGSSLAVAWKTK-NPELRQTALAAAASAIMaGISEPAL 378

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 487749481 396 FGVNLKLRYPFIgavagsgigAAYISFFKVKAIAlGTAGL 435
Cdd:PRK09796 379 YGVAIRLKRPLI---------ASLISGFICGAVA-GMAGL 408
PTS_EIIC pfam02378
Phosphotransferase system, EIIC; The bacterial phosphoenolpyruvate: sugar phosphotransferase ...
 110-407 1.55e-55

Phosphotransferase system, EIIC; The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. The sugar-specific permease of the PTS consists of three domains (IIA, IIB and IIC). The IIC domain catalyzes the transfer of a phosphoryl group from IIB to the sugar substrate.


Pssm-ID: 367061  Cd Length: 315  Bit Score: 187.55  E-value: 1.55e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  110 SDIFVPIIPAIVAGGLLMGLNNIFTAKDLFYDGKSIIDvhsqfSGLADMINIFANAPFTLLPILIGFSAAKRF-GGNPYL 188
Cdd:pfam02378   1 GDGFMPPIPLLIAGGILLGLGNLPNDTTGLPAGGFTGD-----SPLAEILKQAGSAAFGILPILFAIGIAYGLaGGDGVA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  189 GAALGMILVHPGLMSAYDFPKALEEGKAipHWDVFGLHINEVGYQGQVLPMLVATYILATIEKWLRKVIPTVLDNLLTPL 268
Cdd:pfam02378  76 GAAGLIGLLSFNLAAAISVALTAAGLSG--GGNILGIGLGATGVFGAIIPGLLAAYLYNRFEKNITIKLPDSLPFFVGKR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  269 LSIFITAFITFLFVGPVTRQLGYWLSDGLT----WLYEFGGAIGGLIFGLLYAPIVITGMHHSFIAVETTLIADATKTGG 344
Cdd:pfam02378 154 FVPIITGFVTLLVIGPVLGLIWPAIQGGLNalglLLIIAGGILGGLIFGFLERLLWPFGLHGAFIAIFWFLPIGGSNPIA 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487749481  345 SFI------------FPIATMSNIAQGGAALAAFFIIKQNKKLKGVASAAGISALLGITEPAMFGVNLKLRYPFI 407
Cdd:pfam02378 234 NQQaygagaahiltgGFDVMFGGPGATLALYAAAFLFKKSKVKKLLGSAALTPFLFGITEPLEFGFPFVLNPPFF 308
murP PRK09586
PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed
 9-459 1.66e-52

PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed


Pssm-ID: 181971 [Multi-domain]  Cd Length: 476  Bit Score: 184.11  E-value: 1.66e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   9 EILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSG---TVNKVFNELEKITGKEA 85
Cdd:PRK09586  11 TILTRVGGPGNIASCGNCMTRLRLTLHDSSLVDPAAIKTIEGVKGVILSDDQVQVVLGPGkaqRAAKAMNELLGEAAAPV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481  86 STTSEVKDKSSKHM-----NPFQKFVKMLSDIFVPIIPAIVAGGLLMGLNNIFtakdlfyDGKSIIDVHSQfSGLADMIN 160
Cdd:PRK09586  91 QDLAEIAAQNKRQLkakqtSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLI-------EQVMHVPADAQ-GTLPDALN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 161 ---IFANAPFTLLPILIGFSAAKRFGGNPYLGAALGMILVhpglmSAYDfPKAlEEGKAIPHWDVFGLHINEvgyQGQVL 237
Cdd:PRK09586 163 ymkVFSKGLFTFLSILIGYNAQQAFGGTGVNGAIIASLFL-----LGYN-PAA-TTGYYAGFHDFFGLPIDP---RGNII 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 238 PMLVATYILATIEKWLRKVIPTVLDNLLTPLLSIFITAFITFLFVGPvtrqLGYWLSDGLTWLYEF--GGAIGGLIFGLL 315
Cdd:PRK09586 233 GVLIAAIAGARIERMVRRFMPDDLDMILTSLITLLITGALAFLIIMP----LGGWLFEGMSWLFMHlnSNPFGCAVLAGL 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 316 YAPIVITGMHHSFIAVETTLIaDAtkTGGSFIFPIATMSNIAQGGAALAAFFIIKQNKKLKGVASAAGISALLGITEPAM 395
Cdd:PRK09586 309 FLIAVVFGVHQGFIPVYFALM-DS--QGFNSLFPILAMAGAGQVGAALALYWRAQKHSALRTQVKGAIIPGLLGVGEPLI 385

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487749481 396 FGVNLKLRYPFIGAVAGSGIGAAYISFFKVKAI------ALGTAG---LPGFISINPTHAGWLHYLIGMLIAF 459
Cdd:PRK09586 386 YGVTLPRMKPFVTACLGGAAGGFFIGLIAWLGLpvglnsVFGPSGlvaLPLMTSAQGILPGMAVYAGGLLVAY 458
PtsG2 COG1264
Phosphotransferase system IIB components [Carbohydrate transport and metabolism];
4-81 1.50e-28

Phosphotransferase system IIB components [Carbohydrate transport and metabolism];


Pssm-ID: 440876 [Multi-domain]  Cd Length: 76  Bit Score: 107.51  E-value: 1.50e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487749481   4 KKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDvVKGTFSTGGQYQIIIGSGtVNKVFNELEKIT 81
Cdd:COG1264    1 KELAKDILEALGGKENIVSVDHCATRLRVTVKDPSKVDEAALKKLG-VKGVVKNGGQVQVIIGPG-VDKVADEIEKLL 76
PTS_IIB_glc cd00212
PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: ...
 7-82 2.37e-28

PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIB PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation


Pssm-ID: 238130 [Multi-domain]  Cd Length: 78  Bit Score: 107.23  E-value: 2.37e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487749481   7 AEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSGtVNKVFNELEKITG 82
Cdd:cd00212    4 AKDILEALGGKENIVSLDHCATRLRLTVKDESKVDEAALKKLGGVKGVVKNGGQYQVIIGPG-VADVYKEAIKLLG 78
EIIB_glc TIGR00826
PTS system, glucose-like IIB component; The PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) ...
 28-111 5.54e-20

PTS system, glucose-like IIB component; The PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the E. coli PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. This model is specific for the IIB domain of the Glc family PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273288 [Multi-domain]  Cd Length: 88  Bit Score: 84.33  E-value: 5.54e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   28 TRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSGTVNKVFNEL--EKITGKEASTTSE--VKDKSSKHMNPFQ 103
Cdd:TIGR00826   1 TRLRLKTPGREKADEEAIAAGEGVKGVFTAAGQIQALGGTGNVNKVDACItrLRVGVADVSKVDDavLKKLGAHGVNPLQ 80


                  ....*...
gi 487749481  104 KFVKMLSD 111
Cdd:TIGR00826  81 RAVQVISG 88
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 3-84 2.77e-18

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 86.24  E-value: 2.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   3 YKKSAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSGTVNKVFNELEKITG 82
Cdd:PRK14905 274 FSEIAIQLIDHLGGKDNISALTHCASRIRVMLRNDGHIDKSAIEKIDCVKGLFSIANQYQIILGAGIVEKIHEEMKALLA 353


                 ..
gi 487749481  83 KE 84
Cdd:PRK14905 354 RE 355
PTS_EIIB pfam00367
phosphotransferase system, EIIB;
8-39 1.43e-12

phosphotransferase system, EIIB;


Pssm-ID: 459785 [Multi-domain]  Cd Length: 32  Bit Score: 61.61  E-value: 1.43e-12
                          10        20        30
                  ....*....|....*....|....*....|..
gi 487749481    8 EEILKAIGGEENLDAMAHCATRLRLVLNDESK 39
Cdd:pfam00367   1 KEILEALGGKENIKSVDHCATRLRLTVKDESK 32
FrwC COG1299
Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and ...
 117-457 3.11e-08

Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism];


Pssm-ID: 440910 [Multi-domain]  Cd Length: 469  Bit Score: 55.66  E-value: 3.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 117 IPAIVAGGLLMGLNNIFtakdlfyDGKSIIDVHSQFSGLADMINIFANAPFTLL-PIL---IGFSAAKRFGGNPylGAAL 192
Cdd:COG1299  144 LPFVVAGGILIALSFLF-------GIYAFDPGDVSEGTLAAALFQIGGAAFGLMvPVLagyIAYSIADRPGLAP--GFIG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 193 GMILVHPGLmsaydfpkaleegkaiphwdvfglhinevGYQGQVLPMLVATYILatieKWLRKVI--PTVLDNLLT---- 266
Cdd:COG1299  215 GLLANNIGA-----------------------------GFLGGIIAGFLAGYVV----LWLKKKIklPKSLEGLKPilii 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 267 PLLSIFITAFITFLFVGPVTRQLGYWLSDGLTWLYEFGGAIGGLIFGLLYA-----PIVITGMhhsfiAVETTLIADatk 341
Cdd:COG1299  262 PLLGTLITGLLMIYVIGPPIAALNTALTNWLNSMSGSNAVLLGAILGAMMAfdmggPVNKAAY-----AFGTGLLAS--- 333

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481 342 tgGSFIFPIATMSNIAQG--GAALAAFFIIKQ-NKKLKGVASAAGISALLGITEPAM-FGVNLKLRYpfIGA-VAGSGIG 416
Cdd:COG1299  334 --GIYAPMAAVMAAGMVPplGLALATLLFKKKfTEEEREAGKAAFILGLSFITEGAIpFAAADPLRV--IPSnMIGSAVA 409

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 487749481 417 AAYISFFKVKAialgTAGLPGFISInPTHAGWLHYLIGMLI 457
Cdd:COG1299  410 GALSMLFGVTL----PAPHGGIFVL-PLVSNPLLYLLAIAI 445
PRK09702 PRK09702
PTS sugar transporter subunit IIB;
7-66 2.06e-06

PTS sugar transporter subunit IIB;


Pssm-ID: 77355 [Multi-domain]  Cd Length: 161  Bit Score: 47.78  E-value: 2.06e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749481   7 AEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIG 66
Cdd:PRK09702  73 AAGILQALGGVGNISSINNCATRLRIALHDMSQTLDDEVFKKLGAHGVFRSGDAIQVIIG 132
PRK10110 PRK10110
PTS maltose transporter subunit IICB;
7-82 1.33e-05

PTS maltose transporter subunit IICB;


Pssm-ID: 182245 [Multi-domain]  Cd Length: 530  Bit Score: 47.42  E-value: 1.33e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487749481   7 AEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVKGTFSTGGQYQIIIGSgTVNKVFNELEKITG 82
Cdd:PRK10110 452 VPAILEALGGADNIVSLDNCITRLRLSVKDMSLVDVQALKDNRAIGVVQLNQHNLQVVIGP-QVQSVKDEMAGLMH 526
EIIB_glc TIGR00826
PTS system, glucose-like IIB component; The PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) ...
 6-66 5.51e-05

PTS system, glucose-like IIB component; The PTS Glucose-Glucoside (Glc) Family (TC 4.A.1) Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the E. coli PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. This model is specific for the IIB domain of the Glc family PTS transporters. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273288 [Multi-domain]  Cd Length: 88  Bit Score: 41.58  E-value: 5.51e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487749481    6 SAEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNmDVVKGTFSTGGQYQIIIG 66
Cdd:TIGR00826  29 TAAGQIQALGGTGNVNKVDACITRLRVGVADVSKVDDAVLKK-LGAHGVNPLQRAVQVISG 88
PRK11089 PRK11089
PTS system glucose-specific transporter subunits IIBC; Provisional
 7-71 7.79e-04

PTS system glucose-specific transporter subunits IIBC; Provisional


Pssm-ID: 182955 [Multi-domain]  Cd Length: 477  Bit Score: 42.01  E-value: 7.79e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487749481   7 AEEILKAIGGEENLDAMAHCATRLRLVLNDESKVDEDTLSNMDVVkGTFSTGGQYQIIIGSGTVN 71
Cdd:PRK11089 402 APALVAAFGGKENITNLDACITRLRVSVADVSKVDQAGLKKLGAA-GVVVAGSGVQAIFGTKSDN 465
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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