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Conserved domains on  [gi|487749868|ref|WP_001831797|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Staphylococcus]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
20-141 2.97e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 44.89  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749868  20 RLLETTHFRDITIDQISENTGISKATIYRRWKDKSSIIMSAFIE-----QSQYIVIHNQDNLYDDLFQFLVKIKDIYKTK 94
Cdd:COG1309   17 ELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERlleelLAALEEALAAEDPRERLRALLRAYLEFLAEN 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 487749868  95 LGSAVIEILISHQQMEAREtFMTNYFNHNRKVLKEIVRKHIQEEEQD 141
Cdd:COG1309   97 PALARLLLAEAAELPELRA-ALRALLRRLRALLAELLRAGGLLADVD 142
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
20-141 2.97e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 44.89  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749868  20 RLLETTHFRDITIDQISENTGISKATIYRRWKDKSSIIMSAFIE-----QSQYIVIHNQDNLYDDLFQFLVKIKDIYKTK 94
Cdd:COG1309   17 ELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERlleelLAALEEALAAEDPRERLRALLRAYLEFLAEN 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 487749868  95 LGSAVIEILISHQQMEAREtFMTNYFNHNRKVLKEIVRKHIQEEEQD 141
Cdd:COG1309   97 PALARLLLAEAAELPELRA-ALRALLRRLRALLAELLRAGGLLADVD 142
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 76-174 1.55e-04

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 39.48  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749868   76 LYDDLFQFLVKIKDIYKTKLGSAVIEILISHQQM--EARETFMTNYFNHNRKVLKEIVRKHIQEEE------QDLFIDLI 147
Cdd:pfam16859   7 LRGDLRALLRALARALTSPRGGALLRALIAAAQRdpELAAALRERFLEPRRAALRAVLERAVARGElrpdadPDLVLDLL 86

                          90       100
                  ....*....|....*....|....*..
gi 487749868  148 FSPIYFNILIKPETLDKNYIKKMLNQV 174
Cdd:pfam16859  87 FGPLYYRLLLTGEPLDEAYADRLVDLV 113
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
20-141 2.97e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 44.89  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749868  20 RLLETTHFRDITIDQISENTGISKATIYRRWKDKSSIIMSAFIE-----QSQYIVIHNQDNLYDDLFQFLVKIKDIYKTK 94
Cdd:COG1309   17 ELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERlleelLAALEEALAAEDPRERLRALLRAYLEFLAEN 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 487749868  95 LGSAVIEILISHQQMEAREtFMTNYFNHNRKVLKEIVRKHIQEEEQD 141
Cdd:COG1309   97 PALARLLLAEAAELPELRA-ALRALLRRLRALLAELLRAGGLLADVD 142
TetR_C_11 pfam16859
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 76-174 1.55e-04

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


Pssm-ID: 435608  Cd Length: 113  Bit Score: 39.48  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749868   76 LYDDLFQFLVKIKDIYKTKLGSAVIEILISHQQM--EARETFMTNYFNHNRKVLKEIVRKHIQEEE------QDLFIDLI 147
Cdd:pfam16859   7 LRGDLRALLRALARALTSPRGGALLRALIAAAQRdpELAAALRERFLEPRRAALRAVLERAVARGElrpdadPDLVLDLL 86

                          90       100
                  ....*....|....*....|....*..
gi 487749868  148 FSPIYFNILIKPETLDKNYIKKMLNQV 174
Cdd:pfam16859  87 FGPLYYRLLLTGEPLDEAYADRLVDLV 113
HTH_7 pfam02796
Helix-turn-helix domain of resolvase;
3-53 2.65e-03

Helix-turn-helix domain of resolvase;


Pssm-ID: 397088 [Multi-domain]  Cd Length: 45  Bit Score: 34.25  E-value: 2.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 487749868    3 GRPkdPTINKKIYTEIQRLLEtthfRDITIDQISENTGISKATIYRRWKDK 53
Cdd:pfam02796   1 GRP--PKLNEEDINEVITLLE----EGISIKQIAKIFGISRSTVYRYLAAS 45
Sigma70_ECF pfam07638
ECF sigma factor; These proteins are probably RNA polymerase sigma factors belonging to the ...
 17-50 6.66e-03

ECF sigma factor; These proteins are probably RNA polymerase sigma factors belonging to the extra-cytoplasmic function (ECF) subfamily and show sequence similarity to pfam04542 and pfam04545.


Pssm-ID: 254323 [Multi-domain]  Cd Length: 185  Bit Score: 35.86  E-value: 6.66e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 487749868   17 EIQRLLETTHFRDITIDQISENTGISKATIYRRW 50
Cdd:pfam07638 139 RQARLVELRFFAGLSNDEIAERLGVSERTVERNW 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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