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Conserved domains on  [gi|487749958|ref|WP_001831870|]
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MULTISPECIES: alpha/beta hydrolase family protein [Staphylococcus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11427881)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
3-252 2.49e-58

S-formylglutathione hydrolase FrmB [Defense mechanisms];


:

Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 185.42  E-value: 2.49e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   3 LITMNYNSPTIGMHQNLTIILPEDvtffdssTTAKHLKSMLLLHGLSSDETTYIRYTSIERYANEHQLAIIMPN-VDHSG 81
Cdd:COG0627    4 VVRVTVPSPALGREMPVSVYLPPG-------YDGRPLPVLYLLHGLTGTHENWTRKTGAQRLAAELGVIVVMPDgGQASF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  82 YANMVYGHS----YYDYIL-EIYEYVHQILPLSRKREDNFIAGHSMGGYGTIKFALTQSDKFAKAAPLSAVFEaqrFIDL 156
Cdd:COG0627   77 YVDWTQGPAghyrWETYLTeELPPLIEANFPVSADRERRAIAGLSMGGHGALTLALRHPDLFRAVAAFSGILD---PSQP 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958 157 DWTDFSPQSITGNNTQIKGTELDTYYLLDQAIDAnvdiPELFIMCGKED-FLYHDNLQFIETLNKKGVSYKFEDGPGNHD 235
Cdd:COG0627  154 PWGEKAFDAYFGPPDRAAWAANDPLALAEKLRAG----LPLYIDCGTADpFFLEANRQLHAALRAAGIPHTYRERPGGHS 229

                        250
                 ....*....|....*..
gi 487749958 236 YAYWDRAIKRAIEWFVQ 252
Cdd:COG0627  230 WYYWASFLEDHLPFLAR 246
 
Name Accession Description Interval E-value
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
3-252 2.49e-58

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 185.42  E-value: 2.49e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   3 LITMNYNSPTIGMHQNLTIILPEDvtffdssTTAKHLKSMLLLHGLSSDETTYIRYTSIERYANEHQLAIIMPN-VDHSG 81
Cdd:COG0627    4 VVRVTVPSPALGREMPVSVYLPPG-------YDGRPLPVLYLLHGLTGTHENWTRKTGAQRLAAELGVIVVMPDgGQASF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  82 YANMVYGHS----YYDYIL-EIYEYVHQILPLSRKREDNFIAGHSMGGYGTIKFALTQSDKFAKAAPLSAVFEaqrFIDL 156
Cdd:COG0627   77 YVDWTQGPAghyrWETYLTeELPPLIEANFPVSADRERRAIAGLSMGGHGALTLALRHPDLFRAVAAFSGILD---PSQP 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958 157 DWTDFSPQSITGNNTQIKGTELDTYYLLDQAIDAnvdiPELFIMCGKED-FLYHDNLQFIETLNKKGVSYKFEDGPGNHD 235
Cdd:COG0627  154 PWGEKAFDAYFGPPDRAAWAANDPLALAEKLRAG----LPLYIDCGTADpFFLEANRQLHAALRAAGIPHTYRERPGGHS 229

                        250
                 ....*....|....*..
gi 487749958 236 YAYWDRAIKRAIEWFVQ 252
Cdd:COG0627  230 WYYWASFLEDHLPFLAR 246
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 10-239 1.75e-07

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 50.54  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   10 SPTIGMHQNLTIILPEDvtffdsSTTAKHLKSMLLLHGLSSDETTYIRYTsIERYANEHQLA----IIMPNVDHSGYANM 85
Cdd:pfam00756   1 SNSLGREMKVQVYLPED------YPPGRKYPVLYLLDGTGWFQNGPAKEG-LDRLAASGEIPpviiVGSPRGGEVSFYSD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   86 VY-------GHSYYDYIleiyEYVHQILP------LSRKREDNFIAGHSMGGYGTIKFALTQSDKFAKAAPLSAVfeAQR 152
Cdd:pfam00756  74 WDrglnateGPGAYAYE----TFLTQELPplldanFPTAPDGRALAGQSMGGLGALYLALKYPDLFGSVSSFSPI--LNP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  153 FIDLDWTDFSPQSITGnntqikgtelDTYYLLDQAIDANvdiPELFIMC--GKEDFLYHDNL------------QFIETL 218
Cdd:pfam00756 148 SNSMWGPEDDPAWQEG----------DPVLLAVALSANN---TRLRIYLdvGTREDFLGDQLpveileelapnrELAEQL 214

                         250       260
                  ....*....|....*....|.
gi 487749958  219 NKKGVSYKFEDGPGNHDYAYW 239
Cdd:pfam00756 215 AYRGVGGYDHEYYGGHDWAYW 235
PLN02442 PLN02442
S-formylglutathione hydrolase
 10-147 5.97e-05

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 43.23  E-value: 5.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  10 SPTIGMHQNLTIilpedvtFFDSSTTAKHLKSMLLLHGLSSDETTYIRYTSIERYANEHQLAIIMPnvDHSGYANMVYGH 89
Cdd:PLN02442  25 SSTLGCSMTFSV-------YFPPASDSGKVPVLYWLSGLTCTDENFIQKSGAQRAAAARGIALVAP--DTSPRGLNVEGE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  90 S-----------YYDYILE------IYEYVHQILP--LSrkreDNF---------IAGHSMGGYGTIKFALTQSDKFAKA 141
Cdd:PLN02442  96 AdswdfgvgagfYLNATQEkwknwrMYDYVVKELPklLS----DNFdqldtsrasIFGHSMGGHGALTIYLKNPDKYKSV 171


                 ....*.
gi 487749958 142 APLSAV 147
Cdd:PLN02442 172 SAFAPI 177
 
Name Accession Description Interval E-value
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
3-252 2.49e-58

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 185.42  E-value: 2.49e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   3 LITMNYNSPTIGMHQNLTIILPEDvtffdssTTAKHLKSMLLLHGLSSDETTYIRYTSIERYANEHQLAIIMPN-VDHSG 81
Cdd:COG0627    4 VVRVTVPSPALGREMPVSVYLPPG-------YDGRPLPVLYLLHGLTGTHENWTRKTGAQRLAAELGVIVVMPDgGQASF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  82 YANMVYGHS----YYDYIL-EIYEYVHQILPLSRKREDNFIAGHSMGGYGTIKFALTQSDKFAKAAPLSAVFEaqrFIDL 156
Cdd:COG0627   77 YVDWTQGPAghyrWETYLTeELPPLIEANFPVSADRERRAIAGLSMGGHGALTLALRHPDLFRAVAAFSGILD---PSQP 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958 157 DWTDFSPQSITGNNTQIKGTELDTYYLLDQAIDAnvdiPELFIMCGKED-FLYHDNLQFIETLNKKGVSYKFEDGPGNHD 235
Cdd:COG0627  154 PWGEKAFDAYFGPPDRAAWAANDPLALAEKLRAG----LPLYIDCGTADpFFLEANRQLHAALRAAGIPHTYRERPGGHS 229

                        250
                 ....*....|....*..
gi 487749958 236 YAYWDRAIKRAIEWFVQ 252
Cdd:COG0627  230 WYYWASFLEDHLPFLAR 246
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
3-250 8.27e-32

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 118.80  E-value: 8.27e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   3 LITMNYNSPTIGMHQNLTIILPEDvtfFDSSTTAKHLksMLLLHGLSSDETTYIRY----TSIERYANEHQL---AIIMP 75
Cdd:COG2382   81 VETVTYPSKALGRTRRVWVYLPPG---YDNPGKKYPV--LYLLDGGGGDEQDWFDQgrlpTILDNLIAAGKIppmIVVMP 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  76 NVDHSGYANMVYGHS--YYDYIL-EIYEYVHQILPLSRKREDNFIAGHSMGGYGTIKFALTQSDKFAKAAPLSAVFeaqr 152
Cdd:COG2382  156 DGGDGGDRGTEGPGNdaFERFLAeELIPFVEKNYRVSADPEHRAIAGLSMGGLAALYAALRHPDLFGYVGSFSGSF---- 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958 153 fidldWTDFSPQSITGNNTQIKgteldtyyllDQAIDANVDIpelFIMCGKEDFLYHDNLQFIETLNKKGVSYKFEDGPG 232
Cdd:COG2382  232 -----WWPPGDADRGGWAELLA----------AGAPKKPLRF---YLDVGTEDDLLEANRALAAALKAKGYDVEYREFPG 293

                        250
                 ....*....|....*...
gi 487749958 233 NHDYAYWDRAIKRAIEWF 250
Cdd:COG2382  294 GHDWAVWRAALPDFLPWL 311
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
20-252 5.23e-08

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 51.94  E-value: 5.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  20 TIILPEDvtffdssttAKHLKSMLLLHGlsSDETTYIRYTSIERYANEHQLAIIMPNVDHSGYANMVYGHSYYDYILEIY 99
Cdd:COG1506   13 WLYLPAD---------GKKYPVVVYVHG--GPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVLAAI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958 100 EYVHQILPLSRKRedNFIAGHSMGGYGTIKFALTQSDKFAKAAPLSAVFeaqrfidlDWTDFSPQSITGNNTQIKG---- 175
Cdd:COG1506   82 DYLAARPYVDPDR--IGIYGHSYGGYMALLAAARHPDRFKAAVALAGVS--------DLRSYYGTTREYTERLMGGpwed 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958 176 -TELDTYYLLDQAidANVDIPeLFIMCGKEDFL--YHDNLQFIETLNKKGVSYKFEDGPG-NHDY--AYWDRAIKRAIEW 249
Cdd:COG1506  152 pEAYAARSPLAYA--DKLKTP-LLLIHGEADDRvpPEQAERLYEALKKAGKPVELLVYPGeGHGFsgAGAPDYLERILDF 228


                 ...
gi 487749958 250 FVQ 252
Cdd:COG1506  229 LDR 231
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 10-239 1.75e-07

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 50.54  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   10 SPTIGMHQNLTIILPEDvtffdsSTTAKHLKSMLLLHGLSSDETTYIRYTsIERYANEHQLA----IIMPNVDHSGYANM 85
Cdd:pfam00756   1 SNSLGREMKVQVYLPED------YPPGRKYPVLYLLDGTGWFQNGPAKEG-LDRLAASGEIPpviiVGSPRGGEVSFYSD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   86 VY-------GHSYYDYIleiyEYVHQILP------LSRKREDNFIAGHSMGGYGTIKFALTQSDKFAKAAPLSAVfeAQR 152
Cdd:pfam00756  74 WDrglnateGPGAYAYE----TFLTQELPplldanFPTAPDGRALAGQSMGGLGALYLALKYPDLFGSVSSFSPI--LNP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  153 FIDLDWTDFSPQSITGnntqikgtelDTYYLLDQAIDANvdiPELFIMC--GKEDFLYHDNL------------QFIETL 218
Cdd:pfam00756 148 SNSMWGPEDDPAWQEG----------DPVLLAVALSANN---TRLRIYLdvGTREDFLGDQLpveileelapnrELAEQL 214

                         250       260
                  ....*....|....*....|.
gi 487749958  219 NKKGVSYKFEDGPGNHDYAYW 239
Cdd:pfam00756 215 AYRGVGGYDHEYYGGHDWAYW 235
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
43-250 3.94e-07

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 49.23  E-value: 3.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  43 LLLHGLSSdetTYIRYTSIERYANEHQLAIIMPnvDHSGY----ANMVYGHSYYDYILEIYEYVHQIlplsRKREDN--F 116
Cdd:COG2267   32 VLVHGLGE---HSGRYAELAEALAAAGYAVLAF--DLRGHgrsdGPRGHVDSFDDYVDDLRAALDAL----RARPGLpvV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958 117 IAGHSMGGYGTIKFALTQSDKFAkaaplSAVFEAQRFIDLDWTDFSPQSitgnntqikgteLDTYYLLDQAidANVDIPe 196
Cdd:COG2267  103 LLGHSMGGLIALLYAARYPDRVA-----GLVLLAPAYRADPLLGPSARW------------LRALRLAEAL--ARIDVP- 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 487749958 197 LFIMCGKEDFL--YHDNLQFIETLNKKGVSYKFEDgpGNHD---YAYWDRAIKRAIEWF 250
Cdd:COG2267  163 VLVLHGGADRVvpPEAARRLAARLSPDVELVLLPG--ARHEllnEPAREEVLAAILAWL 219
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 42-148 4.28e-06

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 46.92  E-value: 4.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  42 MLLLHGLSSDETTYIRYTSIERYANEHQLAIIMPNvdhsGYANMVYGH-SYYD------------YILEIYEYVHQILPL 108
Cdd:COG3509   56 VVALHGCGGSAADFAAGTGLNALADREGFIVVYPE----GTGRAPGRCwNWFDgrdqrrgrddvaFIAALVDDLAARYGI 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 487749958 109 SRKRedNFIAGHSMGGYGTIKFALTQSDKFAKAAPLSAVF 148
Cdd:COG3509  132 DPKR--VYVTGLSAGGAMAYRLACEYPDVFAAVAPVAGLP 169
COG4099 COG4099
Predicted peptidase [General function prediction only];
42-146 2.74e-05

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 44.19  E-value: 2.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  42 MLLLHGLS---SDETTYIRYTSI----ERYANEHQLAIIMPNVDHSGYANmvyGHSYYDYILEIYEYVHQILPLSRKREd 114
Cdd:COG4099   52 VLFLHGAGergTDNEKQLTHGAPkfinPENQAKFPAIVLAPQCPEDDYWS---DTKALDAVLALLDDLIAEYRIDPDRI- 127

                         90       100       110
                 ....*....|....*....|....*....|..
gi 487749958 115 nFIAGHSMGGYGTIKFALTQSDKFAKAAPLSA 146
Cdd:COG4099  128 -YLTGLSMGGYGTWDLAARYPDLFAAAVPICG 158
PLN02442 PLN02442
S-formylglutathione hydrolase
 10-147 5.97e-05

S-formylglutathione hydrolase


Pssm-ID: 178061 [Multi-domain]  Cd Length: 283  Bit Score: 43.23  E-value: 5.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  10 SPTIGMHQNLTIilpedvtFFDSSTTAKHLKSMLLLHGLSSDETTYIRYTSIERYANEHQLAIIMPnvDHSGYANMVYGH 89
Cdd:PLN02442  25 SSTLGCSMTFSV-------YFPPASDSGKVPVLYWLSGLTCTDENFIQKSGAQRAAAARGIALVAP--DTSPRGLNVEGE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958  90 S-----------YYDYILE------IYEYVHQILP--LSrkreDNF---------IAGHSMGGYGTIKFALTQSDKFAKA 141
Cdd:PLN02442  96 AdswdfgvgagfYLNATQEkwknwrMYDYVVKELPklLS----DNFdqldtsrasIFGHSMGGHGALTIYLKNPDKYKSV 171


                 ....*.
gi 487749958 142 APLSAV 147
Cdd:PLN02442 172 SAFAPI 177
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 36-146 2.24e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 38.35  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487749958   36 AKHLKSMLLLHGLSSdettyirytSIERYAN-EHQLAiimpnvdHSGYAnmVY-----GH-----------SYYDYILEI 98
Cdd:pfam12146   1 GEPRAVVVLVHGLGE---------HSGRYAHlADALA-------AQGFA--VYaydhrGHgrsdgkrghvpSFDDYVDDL 62

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 487749958   99 YEYVHQI------LPLsrkrednFIAGHSMGGYGTIKFALTQSDKFAKAApLSA 146
Cdd:pfam12146  63 DTFVDKIreehpgLPL-------FLLGHSMGGLIAALYALRYPDKVDGLI-LSA 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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