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Conserved domains on  [gi|487859025|ref|WP_001932491|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Vibrio]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 14302105)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_30 pfam17939
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 93-204 4.24e-32

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in the Pseudomonas aeruginosa PsrA which regulates the fadBA5 beta-oxidation operon. Functional analysis of PsrA indicated its importance in regulating b-oxidative enzymes. It has also been suggested that PsrA, a member of the TetR family of repressors, could affect global gene expression including activation of rpoS.


:

Pssm-ID: 465577  Cd Length: 113  Bit Score: 112.33  E-value: 4.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859025   93 DPLRSLSELRPNGTSRFMLLIGRGYTDVQGHLRWFITNRYNDVLTLFTDSVLKANPNLTRETLFWRLHFTLGTCVFTMAS 172
Cdd:pfam17939   3 RPLLELSQTGGEGGRAFARLLARLYSEPDEELRELIAEEYDPVARRFIAALRRALPDLPREELFWRLHFMLGALLFTLAD 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 487859025  173 SQALaEIAENDFGSKVDPKSVVDQLIPYLAAG 204
Cdd:pfam17939  83 TGRL-DILSGGLCSSADLEALIERLVPFLAAG 113
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-97 2.93e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 75.32  E-value: 2.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859025   4 RSSTKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAVLNRYLEAFMPEMKQSLERLNERDdyD 83
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRE--R 81

                         90
                 ....*....|....
gi 487859025  84 MAEVFEALRDPLRS 97
Cdd:COG1309   82 LRALLRAYLEFLAE 95
 
Name Accession Description Interval E-value
TetR_C_30 pfam17939
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 93-204 4.24e-32

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in the Pseudomonas aeruginosa PsrA which regulates the fadBA5 beta-oxidation operon. Functional analysis of PsrA indicated its importance in regulating b-oxidative enzymes. It has also been suggested that PsrA, a member of the TetR family of repressors, could affect global gene expression including activation of rpoS.


Pssm-ID: 465577  Cd Length: 113  Bit Score: 112.33  E-value: 4.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859025   93 DPLRSLSELRPNGTSRFMLLIGRGYTDVQGHLRWFITNRYNDVLTLFTDSVLKANPNLTRETLFWRLHFTLGTCVFTMAS 172
Cdd:pfam17939   3 RPLLELSQTGGEGGRAFARLLARLYSEPDEELRELIAEEYDPVARRFIAALRRALPDLPREELFWRLHFMLGALLFTLAD 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 487859025  173 SQALaEIAENDFGSKVDPKSVVDQLIPYLAAG 204
Cdd:pfam17939  83 TGRL-DILSGGLCSSADLEALIERLVPFLAAG 113
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-97 2.93e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 75.32  E-value: 2.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859025   4 RSSTKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAVLNRYLEAFMPEMKQSLERLNERDdyD 83
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRE--R 81

                         90
                 ....*....|....
gi 487859025  84 MAEVFEALRDPLRS 97
Cdd:COG1309   82 LRALLRAYLEFLAE 95
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
11-57 5.34e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 52.80  E-value: 5.34e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 487859025   11 ILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAV 57
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 5-70 6.93e-06

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 44.92  E-value: 6.93e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487859025   5 SSTKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAVLNRYLEAFMPEMK 70
Cdd:PRK15008  17 SAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLK 82
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-60 7.93e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 44.51  E-value: 7.93e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 487859025   7 TKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAVLNR 60
Cdd:NF041196   7 TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE 60
 
Name Accession Description Interval E-value
TetR_C_30 pfam17939
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 93-204 4.24e-32

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present in the Pseudomonas aeruginosa PsrA which regulates the fadBA5 beta-oxidation operon. Functional analysis of PsrA indicated its importance in regulating b-oxidative enzymes. It has also been suggested that PsrA, a member of the TetR family of repressors, could affect global gene expression including activation of rpoS.


Pssm-ID: 465577  Cd Length: 113  Bit Score: 112.33  E-value: 4.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859025   93 DPLRSLSELRPNGTSRFMLLIGRGYTDVQGHLRWFITNRYNDVLTLFTDSVLKANPNLTRETLFWRLHFTLGTCVFTMAS 172
Cdd:pfam17939   3 RPLLELSQTGGEGGRAFARLLARLYSEPDEELRELIAEEYDPVARRFIAALRRALPDLPREELFWRLHFMLGALLFTLAD 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 487859025  173 SQALaEIAENDFGSKVDPKSVVDQLIPYLAAG 204
Cdd:pfam17939  83 TGRL-DILSGGLCSSADLEALIERLVPFLAAG 113
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-97 2.93e-17

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 75.32  E-value: 2.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859025   4 RSSTKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAVLNRYLEAFMPEMKQSLERLNERDdyD 83
Cdd:COG1309    4 REATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALEEALAAEDPRE--R 81

                         90
                 ....*....|....
gi 487859025  84 MAEVFEALRDPLRS 97
Cdd:COG1309   82 LRALLRAYLEFLAE 95
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
11-57 5.34e-10

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 52.80  E-value: 5.34e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 487859025   11 ILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAV 57
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
7-129 7.84e-09

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 53.02  E-value: 7.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487859025   7 TKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAVLNRYLEAFMPEMKQSLERLNERDDY--DM 84
Cdd:COG3226    9 RRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAaeAL 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 487859025  85 AEVFEAL----RDPLRSLSELRPNGTSRFML--LIGRGYTDVQGHLRWFIT 129
Cdd:COG3226   89 ADLLAELlpadRDRLLARYELYLEALRDPELraLLRRWRDRLREALARLLA 139
PRK15008 PRK15008
HTH-type transcriptional regulator RutR; Provisional
 5-70 6.93e-06

HTH-type transcriptional regulator RutR; Provisional


Pssm-ID: 184970 [Multi-domain]  Cd Length: 212  Bit Score: 44.92  E-value: 6.93e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487859025   5 SSTKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAVLNRYLEAFMPEMK 70
Cdd:PRK15008  17 SAKKKAILSAALDTFSQFGFHGTRLEQIAELAGVSKTNLLYYFPSKEALYIAVLRQILDIWLAPLK 82
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
7-60 7.93e-06

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 44.51  E-value: 7.93e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 487859025   7 TKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTLVRAVLNR 60
Cdd:NF041196   7 TRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE 60
PRK11552 PRK11552
putative DNA-binding transcriptional regulator; Provisional
 8-57 1.95e-05

putative DNA-binding transcriptional regulator; Provisional


Pssm-ID: 236928 [Multi-domain]  Cd Length: 225  Bit Score: 43.89  E-value: 1.95e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 487859025   8 KEKILDVAEGLFAEYGFNDTSlRTITSKAGVNLASVNYHFGDKKTLVRAV 57
Cdd:PRK11552  15 KQQLIAAALAQFGEYGLHATT-RDIAAQAGQNIAAITYYFGSKEDLYLAV 63
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 7-53 3.31e-05

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 43.07  E-value: 3.31e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 487859025   7 TKEKILDVAEGLFAEYGFNDTSLRTITSKAGVNLASVNYHFGDKKTL 53
Cdd:PRK10668  12 TRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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