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Conserved domains on  [gi|487961712|ref|WP_002035014|]
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MULTISPECIES: M48 family metallopeptidase [Bacillus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11469162)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 140-269 1.60e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 140 VHYAATTINLLNERYEKQIEYLNKQFLQNPQNEIAKELVSNYlrYINSGLLsnqqkekiiAEFMNFITQGVELFPNEPLY 219
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEI--LLQLGDL---------DEAIVLLHEALELDPDEPEA 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 487961712 220 PFHLGNLFLHTKQYAKSEEQFLNLIHFYPESYYGYVGLLEIYYEQQLWDE 269
Cdd:COG4783   75 RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 140-269 1.60e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 140 VHYAATTINLLNERYEKQIEYLNKQFLQNPQNEIAKELVSNYlrYINSGLLsnqqkekiiAEFMNFITQGVELFPNEPLY 219
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEI--LLQLGDL---------DEAIVLLHEALELDPDEPEA 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 487961712 220 PFHLGNLFLHTKQYAKSEEQFLNLIHFYPESYYGYVGLLEIYYEQQLWDE 269
Cdd:COG4783   75 RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 199-250 3.88e-04

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 39.57  E-value: 3.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 487961712  199 IAEFMNFITQgvelFPNEPLYP---FHLGNLFLHTKQYAKSEEQFLNLIHFYPES 250
Cdd:TIGR02795  20 IQAFQAFLKK----YPKSTYAPnahYWLGEAYYAQGDYADAAKAFLAVVKKYPKS 70
 
Name Accession Description Interval E-value
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 140-269 1.60e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 140 VHYAATTINLLNERYEKQIEYLNKQFLQNPQNEIAKELVSNYlrYINSGLLsnqqkekiiAEFMNFITQGVELFPNEPLY 219
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEI--LLQLGDL---------DEAIVLLHEALELDPDEPEA 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 487961712 220 PFHLGNLFLHTKQYAKSEEQFLNLIHFYPESYYGYVGLLEIYYEQQLWDE 269
Cdd:COG4783   75 RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 149-269 4.56e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 4.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 149 LLNERYEKQIEYLNKQFLQNPQN-EIAKELVSNYLRyinsgllsNQQKEKIIAEFmnfiTQGVELFPNEPLYPFHLGNLF 227
Cdd:COG2956   19 LLNGQPDKAIDLLEEALELDPETvEAHLALGNLYRR--------RGEYDRAIRIH----QKLLERDPDRAEALLELAQDY 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 487961712 228 LHTKQYAKSEEQFLNLIHFYPESYYGYVGLLEIYYEQQLWDE 269
Cdd:COG2956   87 LKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK 128
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 189-269 1.04e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.13  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 189 LLSNQQKEKIIAEFMNFITQgvelFPNEPLYP---FHLGNLFLHTKQYAKSEEQFLNLIHFYPESYY---GYVGLLEIYY 262
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKR----YPNSPLAPdalYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYL 78


                 ....*..
gi 487961712 263 EQQLWDE 269
Cdd:COG1729   79 ELGDYDK 85
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 199-250 3.88e-04

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 39.57  E-value: 3.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 487961712  199 IAEFMNFITQgvelFPNEPLYP---FHLGNLFLHTKQYAKSEEQFLNLIHFYPES 250
Cdd:TIGR02795  20 IQAFQAFLKK----YPKSTYAPnahYWLGEAYYAQGDYADAAKAFLAVVKKYPKS 70
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 126-277 2.09e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 126 GLLKEAIHH------KDP--ETVHYAATTINLLNERYEKQIEYLNKQFLQNPQNEIAK-ELVSNYLRyinsgllsNQQKE 196
Cdd:COG2956   90 GLLDRAEELleklleLDPddAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYcELAELYLE--------QGDYD 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 197 KIIAEFmnfiTQGVELFPNEPLYPFHLGNLFLHTKQYAKSEEQFLNLIHFYPESYYGYVGLLEIYYEQQLWDELYNLINN 276
Cdd:COG2956  162 EAIEAL----EKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRK 237


                 .
gi 487961712 277 L 277
Cdd:COG2956  238 A 238
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 130-269 6.63e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.40  E-value: 6.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 130 EAIHHKDPETV--HYAATTINLLNERYEKQIEYLNKQFLQNPQNEIAK-ELVSNYLRyinSGLLsnqqkEKIIAEFMnfi 206
Cdd:COG2956   32 EEALELDPETVeaHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALlELAQDYLK---AGLL-----DRAEELLE--- 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487961712 207 tQGVELFPNEPLYPFHLGNLFLHTKQYAKSEEQFLNLIHFYPESYYGYVGLLEIYYEQQLWDE 269
Cdd:COG2956  101 -KLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDE 162
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 131-269 9.31e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.09  E-value: 9.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487961712 131 AIHHKDPETVHYAATTINLLNERYEKQIEYLNKQFLQNPQNEIAKELVSNYLRYINSGLLSNQQKEkiIAEFMNFITQGV 210
Cdd:COG5010    4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGD--FEESLALLEQAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 487961712 211 ELFPNEPLYPFHLGNLFLHTKQYAKSEEQFLNLIHFYPESYYGYVGLLEIYYEQQLWDE 269
Cdd:COG5010   82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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