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Conserved domains on  [gi|487994645|ref|WP_002066704|]
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MULTISPECIES: GntR family transcriptional regulator [Bacillus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-233 1.43e-66

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 205.48  E-value: 1.43e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   4 KYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDyiNLGSLRG 83
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY--PLSRLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645  84 LTKNLVSQNIE--TKVLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDII-LYLNEDIALSSVY 160
Cdd:COG2188   84 FTEELRARGREpsTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFpGLLEEDLETGSLY 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487994645 161 SYFIEDLRLNIGFADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTKLLNRIN 233
Cdd:COG2188  164 ELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-233 1.43e-66

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 205.48  E-value: 1.43e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   4 KYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDyiNLGSLRG 83
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY--PLSRLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645  84 LTKNLVSQNIE--TKVLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDII-LYLNEDIALSSVY 160
Cdd:COG2188   84 FTEELRARGREpsTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFpGLLEEDLETGSLY 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487994645 161 SYFIEDLRLNIGFADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTKLLNRIN 233
Cdd:COG2188  164 ELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-227 1.08e-35

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 123.56  E-value: 1.08e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645    94 ETKVLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDIILYLNEDIALSSVYSYFIEDLRLNIGF 173
Cdd:smart00866   7 TTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGLKIVR 86

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 487994645   174 ---ADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTK 227
Cdd:smart00866  87 strAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 92-227 2.93e-32

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 114.62  E-value: 2.93e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   92 NIETKVLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDII-LYLNEDIALSSVYSYFIEDLRLN 170
Cdd:pfam07702   5 EPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVpDLLEEDLEEGSLYDYLEERYGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 487994645  171 IGFADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTK 227
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 3-229 2.63e-30

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 112.57  E-value: 2.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645    3 AKYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDYINLGSLr 82
Cdd:TIGR02325   8 ALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTR- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   83 gLTKNLVSQNIETKVLELEVID--ADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDIILYLNEDIALSSVY 160
Cdd:TIGR02325  87 -FSQNLADQGREPTGELLLSDLepASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASGSI 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487994645  161 SYFIEDLrlniGFAD-----KVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTKLL 229
Cdd:TIGR02325 166 TDALREQ----GVADyrrssTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFT 235
PRK09764 PRK09764
GntR family transcriptional regulator;
1-221 2.60e-27

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 104.52  E-value: 2.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   1 MSAK--YKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTdyINL 78
Cdd:PRK09764   1 MGHKplYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVN--YDI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645  79 GSLRGLTKNLVSQNIETK--VLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDIILYLNEDIAL 156
Cdd:PRK09764  79 FQLTSFDEKLSDRHVDTHseVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVME 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487994645 157 SSVYSYFIEDLRLNIGFADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMF 221
Cdd:PRK09764 159 NSKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAF 223
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-68 7.99e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 79.80  E-value: 7.99e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487994645   4 KYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLR 68
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-233 1.43e-66

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 205.48  E-value: 1.43e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   4 KYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDyiNLGSLRG 83
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY--PLSRLTS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645  84 LTKNLVSQNIE--TKVLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDII-LYLNEDIALSSVY 160
Cdd:COG2188   84 FTEELRARGREpsTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFpGLLEEDLETGSLY 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487994645 161 SYFIEDLRLNIGFADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTKLLNRIN 233
Cdd:COG2188  164 ELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELR 236
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-227 1.08e-35

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 123.56  E-value: 1.08e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645    94 ETKVLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDIILYLNEDIALSSVYSYFIEDLRLNIGF 173
Cdd:smart00866   7 TTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERLGLKIVR 86

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 487994645   174 ---ADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTK 227
Cdd:smart00866  87 strAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 92-227 2.93e-32

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 114.62  E-value: 2.93e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   92 NIETKVLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDII-LYLNEDIALSSVYSYFIEDLRLN 170
Cdd:pfam07702   5 EPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVpDLLEEDLEEGSLYDYLEERYGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 487994645  171 IGFADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTK 227
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 3-229 2.63e-30

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 112.57  E-value: 2.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645    3 AKYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDYINLGSLr 82
Cdd:TIGR02325   8 ALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTR- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   83 gLTKNLVSQNIETKVLELEVID--ADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDIILYLNEDIALSSVY 160
Cdd:TIGR02325  87 -FSQNLADQGREPTGELLLSDLepASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASGSI 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487994645  161 SYFIEDLrlniGFAD-----KVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMFHYEKTKLL 229
Cdd:TIGR02325 166 TDALREQ----GVADyrrssTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFT 235
PRK09764 PRK09764
GntR family transcriptional regulator;
1-221 2.60e-27

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 104.52  E-value: 2.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   1 MSAK--YKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTdyINL 78
Cdd:PRK09764   1 MGHKplYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVN--YDI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645  79 GSLRGLTKNLVSQNIETK--VLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDIILYLNEDIAL 156
Cdd:PRK09764  79 FQLTSFDEKLSDRHVDTHseVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVME 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487994645 157 SSVYSYFIEDLRLNIGFADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTIFELSQSMF 221
Cdd:PRK09764 159 NSKYHFIEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAF 223
PRK11402 PRK11402
transcriptional regulator PhoB;
5-234 1.88e-23

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 94.52  E-value: 1.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   5 YKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDyiNLGSLRGL 84
Cdd:PRK11402  11 YATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEN--ALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645  85 TKNLVSQNIETK--VLELEVIDADeEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDIILYLNEDIALS-SVYS 161
Cdd:PRK11402  89 TDFGVSQGKATKekVIEQERVSAA-PFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsSTYQ 167

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487994645 162 YFIEDLRLNIGFADKVISCEKVNKENAQLLELNEGDPALLIENTVHLVNGTifELSQSMFHYEKtkllNRINF 234
Cdd:PRK11402 168 LFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDK--PVHVSELFCRA----NRVTL 234
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 4-68 7.99e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 79.80  E-value: 7.99e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487994645   4 KYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLR 68
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 4-66 4.93e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 4.93e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487994645    4 KYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMF 66
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTF 63
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
5-111 7.25e-14

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 68.42  E-value: 7.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   5 YKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDYIN-LGSLRG 83
Cdd:COG2186    9 AEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDpLALLLA 88

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 487994645  84 LTKNLVSQNIET-KVLELEVIDA------DEEIAK 111
Cdd:COG2186   89 LDDASLRDLLEArLALEPEAARLaaeratDEDLAR 123
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
8-66 2.34e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 62.59  E-value: 2.34e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 487994645     8 IADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMF 66
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTF 59
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 4-202 1.17e-12

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 65.18  E-value: 1.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   4 KYKQIADVLEQDIRdGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMfLRETSVTDYiNLGSLRG 83
Cdd:PRK10079  13 RYQEIAAKLEQELR-QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGV-LVLMRPYDY-PLNAQAR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645  84 LTKNLVSQNIE-TKVLELEVID-ADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIeVSYFKKDIILY-LNEDIALSSVY 160
Cdd:PRK10079  90 FSQNLLDQGSHpTSEKLLSVLRpASGHVADALGITEGENVIHLRTLRRVNGVALCL-IDHYFADLTWWpTLQRFDSGSLH 168

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 487994645 161 SYFIEDLRLNIGFADKVISCEKVNKENAQLLELNEGDPALLI 202
Cdd:PRK10079 169 DFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCV 210
PRK14999 PRK14999
histidine utilization repressor; Provisional
 5-205 1.20e-11

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 62.26  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   5 YKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDyiNLGSLRGL 84
Cdd:PRK14999  14 YETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQS--ALFEVRSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645  85 TKNLVSQNIE--TKVLELEVIDADEEIAKQMQCEVGTRLYFLKRLRIVDGKPFSIEVSYFKKDIIL-YLNEDIALSSVYS 161
Cdd:PRK14999  92 AEEIAARRHQhrCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVdYLTQDYRQTTPHA 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 487994645 162 YFIEDLRLNIGfaDKVISCEKVNKENAQLLELNEGDPALLIENT 205
Cdd:PRK14999 172 YLSRIAPLTEG--EHIVEAVRATAQECAWLTIKEHEPCLLIRRT 213
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 4-69 3.12e-11

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 62.15  E-value: 3.12e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487994645   4 KYKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRE 69
Cdd:COG1167   13 LYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
5-69 3.48e-10

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 55.57  E-value: 3.48e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 487994645   5 YKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRE 69
Cdd:COG1725   12 YEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
7-114 3.30e-07

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 49.54  E-value: 3.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   7 QIADVLEQDIRDGlfnetkKLP-----TEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRETSVTDYINLGSL 81
Cdd:COG1802   15 QVYEALREAILSG------ELPpgerlSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEV 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 487994645  82 RGLtknlvsqnIETKVLEL-------EVIDADEEIAKQMQ 114
Cdd:COG1802   89 RAA--------LEGLAARLaaeratpADLARLRALLEELE 120
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 7-68 2.41e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 47.07  E-value: 2.41e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487994645   7 QIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLR 68
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIR 67
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
4-69 3.86e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 46.55  E-value: 3.86e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487994645   4 KYKQ--IADV----LEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMFLRE 69
Cdd:PRK09464   5 KIRQpkLSDVieqqLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 10-57 2.17e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 44.24  E-value: 2.17e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 487994645  10 DVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYI 57
Cdd:PRK03837  20 ERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLV 67
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 1-66 1.05e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 42.06  E-value: 1.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487994645   1 MSAKYKQIADV----LEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGMF 66
Cdd:PRK09990   1 MKDERRPIADVvaerIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSF 70
PRK11523 PRK11523
transcriptional regulator ExuR;
5-65 1.69e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 41.75  E-value: 1.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487994645   5 YKQIADVLEQDIRDGLFNETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSGM 65
Cdd:PRK11523  10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGI 70
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 1-64 9.67e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 36.05  E-value: 9.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487994645   1 MSAKYKQIADVLEQDIRdglfnETKKLPTEEALMNRFEVSRNTIRKVISQLVNRGYIFQVQGSG 64
Cdd:COG1974    4 LTKRQREILDFIKEYIR-----ERGYPPSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKS 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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