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Conserved domains on  [gi|487995939|ref|WP_002067952|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Bacillus]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-142 4.39e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 114.11  E-value: 4.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487995939   1 MVTEKELELLACLEKNSRLSVDTLAKLLNIEVEEVKKMVTKLESEKIIVDYVTHIDWTKVKEhtGLTAMIDVKVTPKRgv 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGL--GVTAFVEVKVPPHR-- 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487995939  81 gFDAVAEQIYRYSEVKSVYLMSGTYDLSITLEGKTMGEVAMFVSEKLATIESVVSTTTHFIL 142
Cdd:COG1522   78 -LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-142 4.39e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 114.11  E-value: 4.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487995939   1 MVTEKELELLACLEKNSRLSVDTLAKLLNIEVEEVKKMVTKLESEKIIVDYVTHIDWTKVKEhtGLTAMIDVKVTPKRgv 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGL--GVTAFVEVKVPPHR-- 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487995939  81 gFDAVAEQIYRYSEVKSVYLMSGTYDLSITLEGKTMGEVAMFVSEKLATIESVVSTTTHFIL 142
Cdd:COG1522   78 -LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 72-143 2.32e-10

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 53.68  E-value: 2.32e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487995939   72 VKVTPKRGVGFDAVAEQIYRYSEVKSVYLMSGTYDLSITLEGKTMGEVAMFVSEKLATIESVVSTTTHFILK 143
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-107 7.62e-10

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 53.29  E-value: 7.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487995939     4 EKELELLACLEKNSRLSVDTLAKLLNIEVEEVKKMVTKLESEKIIVDYVTHIDWTKVKEhtGLTAMIDVKVtpKRGVGFD 83
Cdd:smart00344   3 EIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGL--SVTAFVGVTL--ENPDKLE 78

                           90       100
                   ....*....|....*....|....
gi 487995939    84 AVAEQIYRYSEVKSVYLMSGTYDL 107
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDY 102
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-142 4.39e-33

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 114.11  E-value: 4.39e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487995939   1 MVTEKELELLACLEKNSRLSVDTLAKLLNIEVEEVKKMVTKLESEKIIVDYVTHIDWTKVKEhtGLTAMIDVKVTPKRgv 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGL--GVTAFVEVKVPPHR-- 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487995939  81 gFDAVAEQIYRYSEVKSVYLMSGTYDLSITLEGKTMGEVAMFVSEKLATIESVVSTTTHFIL 142
Cdd:COG1522   78 -LDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 72-143 2.32e-10

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 53.68  E-value: 2.32e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487995939   72 VKVTPKRGVGFDAVAEQIYRYSEVKSVYLMSGTYDLSITLEGKTMGEVAMFVSEKLATIESVVSTTTHFILK 143
Cdd:pfam01037   1 VEVKLEPGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-107 7.62e-10

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 53.29  E-value: 7.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487995939     4 EKELELLACLEKNSRLSVDTLAKLLNIEVEEVKKMVTKLESEKIIVDYVTHIDWTKVKEhtGLTAMIDVKVtpKRGVGFD 83
Cdd:smart00344   3 EIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGL--SVTAFVGVTL--ENPDKLE 78

                           90       100
                   ....*....|....*....|....
gi 487995939    84 AVAEQIYRYSEVKSVYLMSGTYDL 107
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDY 102
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
4-48 3.46e-04

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 36.64  E-value: 3.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 487995939    4 EKELELLACLEKNSRLSVDTLAKLLNIEVEEVKKMVTKLESEKII 48
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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