|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
7-275 |
1.34e-178 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 492.29 E-value: 1.34e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 7 KTTLHNGVEMPWFGLGVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIragiKEAGISREDLFITSKVWNA 86
Cdd:cd19157 1 TVTLNNGVKMPWLGLGVFKVEEGSEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGI----KESGIPREELFITSKVWNA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 87 DQGYETTLAAYEESLKKLELDYLDLYLVHWPVEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQ 166
Cdd:cd19157 77 DQGYDSTLKAFEASLERLGLDYLDLYLIHWPVKGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 167 VEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANA 246
Cdd:cd19157 157 VEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQLLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENA 236
|
250 260
....*....|....*....|....*....
gi 487996244 247 NIFDFELTKEDMEKIDALNQNHRVGPDPD 275
Cdd:cd19157 237 DVFDFELSQEDMDKIDALNENLRVGPDPD 265
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
12-275 |
9.68e-154 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 429.09 E-value: 9.68e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 12 NGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRagikEAGISREDLFITSKVWNADQGYE 91
Cdd:COG0656 1 NGVEIPALGLGTWQLPGE-EAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHGYD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 92 TTLAAYEESLKKleldyldlyLVHWPVEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQVEYHP 171
Cdd:COG0656 76 DTLAAFEESLERlgldyldlyLIHWPGPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 172 RLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDF 251
Cdd:COG0656 156 YLQQRELLAFCREHGIVVEAYSPLGRGKLLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDF 235
|
250 260
....*....|....*....|....
gi 487996244 252 ELTKEDMEKIDALNQNHRVGPDPD 275
Cdd:COG0656 236 ELSDEDMAAIDALDRGERLGPDPD 259
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
9-277 |
1.53e-141 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 398.81 E-value: 1.53e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRagikEAGISREDLFITSKVWNADQ 88
Cdd:cd19156 2 KLANGVEMPRLGLGVWRVQDGAEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIR----ESGVPREEVFVTTKLWNSDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPVEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQVE 168
Cdd:cd19156 78 GYESTLAAFEESLEKLGLDYVDLYLIHWPVKGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 169 YHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANI 248
Cdd:cd19156 158 LHPLLTQEPLRKFCKEKNIAVEAWSPLGQGKLLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDV 237
|
250 260
....*....|....*....|....*....
gi 487996244 249 FDFELTKEDMEKIDALNQNHRVGPDPDNF 277
Cdd:cd19156 238 FDFELTAEEIRQIDGLNTDHRYGPDPDNF 266
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
9-265 |
5.98e-139 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 391.42 E-value: 5.98e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRagikEAGISREDLFITSKVWNADQ 88
Cdd:cd19126 2 TLNNGTRMPWLGLGVFQTPDGDETERAVQTALENGYRSIDTAAIYKNEEGVGEAIR----ESGVPREELFVTTKLWNDDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPVEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQVE 168
Cdd:cd19126 78 RARRTEDAFQESLDRLGLDYVDLYLIHWPGKDKFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHADVVPAVNQVE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 169 YHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANI 248
Cdd:cd19126 158 FHPYLTQKELRGYCKSKGIVVEAWSPLGQGGLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADI 237
|
250
....*....|....*..
gi 487996244 249 FDFELTKEDMEKIDALN 265
Cdd:cd19126 238 FDFELSEDDMTAIDALN 254
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
16-262 |
1.63e-121 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 347.16 E-value: 1.63e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 16 MPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRagikEAGISREDLFITSKVWNADQGYETTLA 95
Cdd:cd19071 1 MPLIGLGTYKLKPE-ETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIR----ESGVPREELFITTKLWPTDHGYERVRE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AYEESLKKLELDYLDLYLVHWPVEGK-------YKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQVE 168
Cdd:cd19071 76 ALEESLKDLGLDYLDLYLIHWPVPGKeggskeaRLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 169 YHPRLTQKELQAFCKEQGIQMEAWSPLMQG--QLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANA 246
Cdd:cd19071 156 LHPYLQQKELVEFCKEHGIVVQAYSPLGRGrrPLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENL 235
|
250
....*....|....*.
gi 487996244 247 NIFDFELTKEDMEKID 262
Cdd:cd19071 236 DVFDFELSEEDMAAID 251
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
9-265 |
2.72e-118 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 339.35 E-value: 2.72e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAgikeAGISREDLFITSKVWNADQ 88
Cdd:cd19131 3 TLNDGNTIPQLGLGVWQVSND-EAASAVREALEVGYRSIDTAAIYGNEEGVGKAIRA----SGVPREELFITTKLWNSDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPV--EGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQ 166
Cdd:cd19131 78 GYDSTLRAFDESLRKLGLDYVDLYLIHWPVpaQDKYVETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 167 VEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANA 246
Cdd:cd19131 158 IELHPRFQQRELRAFHAKHGIQTESWSPLGQGGLLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENF 237
|
250
....*....|....*....
gi 487996244 247 NIFDFELTKEDMEKIDALN 265
Cdd:cd19131 238 DVFDFELDADDMQAIAGLD 256
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
8-265 |
1.50e-113 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 327.22 E-value: 1.50e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 8 TTLHNGVEMPWFGLGVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIragiKEAGISREDLFITSKVWNAD 87
Cdd:cd19133 1 VTLNNGVEMPILGFGVFQIPDPEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAI----KKSGIPREELFITTKLWIQD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 88 QGYETTLAAYEESLKKLELDYLDLYLVHWPVeGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQV 167
Cdd:cd19133 77 AGYEKAKKAFERSLKRLGLDYLDLYLIHQPF-GDVYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 168 EYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQ--LLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIAN 245
Cdd:cd19133 156 ETHPFNQQIEAVEFLKKYGVQIEAWGPFAEGRnnLFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAEN 235
|
250 260
....*....|....*....|
gi 487996244 246 ANIFDFELTKEDMEKIDALN 265
Cdd:cd19133 236 FDIFDFELSDEDMEAIAALD 255
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
16-264 |
7.30e-110 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 318.04 E-value: 7.30e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 16 MPWFGLGVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQGYETTLA 95
Cdd:cd19136 1 MPILGLGTFRLRGEEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYEKARA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AYEESLKKLELDYLDLYLVHWP-VEGKY----------KDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMI 164
Cdd:cd19136 81 ACLGSLERLGTDYLDLYLIHWPgVQGLKpsdprnaelrRESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 165 NQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQL--LDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRI 242
Cdd:cd19136 161 NQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGDLrlLEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERI 240
|
250 260
....*....|....*....|..
gi 487996244 243 IANANIFDFELTKEDMEKIDAL 264
Cdd:cd19136 241 AENIKVFDFELSEEDMAELNAL 262
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
10-264 |
9.68e-109 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 315.42 E-value: 9.68e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 10 LHNGVEMPWFGLGVFKVedGPELVEAVKVAIKE-GYRSIDTAAIYGNEKAVGegirAGIKEAGISREDLFITSKVWNADQ 88
Cdd:cd19135 7 LSNGVEMPILGLGTSHS--GGYSHEAVVYALKEcGYRHIDTAKRYGCEELLG----KAIKESGVPREDLFLTTKLWPSDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWP---VEGKYK-----DSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEI 160
Cdd:cd19135 81 GYESTKQAFEASLKRLGVDYLDLYLLHWPdcpSSGKNVketraETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 161 KPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQ 240
Cdd:cd19135 161 VPHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAKGKALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEE 240
|
250 260
....*....|....*....|....
gi 487996244 241 RIIANANIFDFELTKEDMEKIDAL 264
Cdd:cd19135 241 RIKENCQVFDFSLSEEDMATLDSL 264
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
8-265 |
2.40e-104 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 304.33 E-value: 2.40e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 8 TTLHNGVEMPWFGLGVFKVEdGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRagikEAGISREDLFITSKVWNAD 87
Cdd:cd19127 1 ITLNNGVEMPALGLGVFQTP-PEETADAVATALADGYRLIDTAAAYGNEREVGEGIR----RSGVDRSDIFVTTKLWISD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 88 QGYETTLAAYEESLKKLELDYLDLYLVHWPVEGKYKD---SWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMI 164
Cdd:cd19127 76 YGYDKALRGFDASLRRLGLDYVDLYLLHWPVPNDFDRtiqAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVPAV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 165 NQVEYHPRLTQKELQAFCKEQGIQMEAWSPL------------MQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVT 232
Cdd:cd19127 156 NQVELHPYFSQKDLRAFHRRLGIVTQAWSPIggvmrygasgptGPGDVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSA 235
|
250 260 270
....*....|....*....|....*....|...
gi 487996244 233 IPKSTKEQRIIANANIFDFELTKEDMEKIDALN 265
Cdd:cd19127 236 IPKSVHPERIAENIDIFDFALSAEDMAAIDALD 268
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
10-270 |
2.23e-96 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 284.95 E-value: 2.23e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 10 LHNGVEMPWFGLGVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQG 89
Cdd:cd19116 5 LNDGNEIPAIALGTWKLKDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLWNSYHE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 90 YETTLAAYEESLKKLELDYLDLYLVHWPVEGK-----------------YKDSWRALETLYKEERVRAIGVSNFQIHHLK 152
Cdd:cd19116 85 REQVEPALRESLKRLGLDYVDLYLIHWPVAFKenndsesngdgslsdidYLETWRGMEDLVKLGLTRSIGVSNFNSEQIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 153 DVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL----MQGQL-----LDNETLQEVADKYGKTTAQIILR 223
Cdd:cd19116 165 RLLSNCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFgrlvPRGQTnppprLDDPTLVAIAKKYGKTTAQIVLR 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 487996244 224 WDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHRV 270
Cdd:cd19116 245 YLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQRV 291
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
1-277 |
7.20e-95 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 280.81 E-value: 7.20e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 1 MKNlQSKTTLHNGVEMPWFGLGVFKVEDgPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIragiKEAGISREDLFIT 80
Cdd:PRK11565 1 MAN-PTVIKLQDGNVMPQLGLGVWQASN-EEVITAIHKALEVGYRSIDTAAIYKNEEGVGKAL----KEASVAREELFIT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 81 SKVWNADQGyeTTLAAYEESLKKLELDYLDLYLVHWPV--EGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGA 158
Cdd:PRK11565 75 TKLWNDDHK--RPREALEESLKKLQLDYVDLYLMHWPVpaIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDET 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 159 EIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQG--QLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKS 236
Cdd:PRK11565 153 GVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGgkGVFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKS 232
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 487996244 237 TKEQRIIANANIFDFELTKEDMEKIDALNQNHRVGPDPDNF 277
Cdd:PRK11565 233 VTPSRIAENFDVFDFRLDKDELGEIAKLDQGKRLGPDPDQF 273
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
10-266 |
2.01e-94 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 278.77 E-value: 2.01e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 10 LHNGVEMPWFGLGVFKVeDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRagikEAGISREDLFITSKVWNADQG 89
Cdd:cd19132 1 LNDGTQIPAIGFGTYPL-KGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVR----RSGVPREELFVTTKLPGRHHG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 90 YETTLAAYEESLKKLELDYLDLYLVHWPV--EGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQV 167
Cdd:cd19132 76 YEEALRTIEESLYRLGLDYVDLYLIHWPNpsRDLYVEAWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVTPAVNQI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 168 EYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQ-LLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANA 246
Cdd:cd19132 156 ELHPYFPQAEQRAYHREHGIVTQSWSPLGRGSgLLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENL 235
|
250 260
....*....|....*....|
gi 487996244 247 NIFDFELTKEDMEKIDALNQ 266
Cdd:cd19132 236 AIFDFELSDEDMAAIAALDR 255
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
10-270 |
2.74e-91 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 272.72 E-value: 2.74e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 10 LHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKE-AGISREDLFITSKVWNADQ 88
Cdd:cd19106 1 LHTGQKMPLIGLGTWKSKPG-QVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVGPgKAVPREDLFVTSKLWNTKH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPVEGK--------------------YKDSWRALETLYKEERVRAIGVSNFQI 148
Cdd:cd19106 80 HPEDVEPALRKTLKDLQLDYLDLYLIHWPYAFErgdnpfpknpdgtirydsthYKETWKAMEKLVDKGLVKAIGLSNFNS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 149 HHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL----------MQGQLLDNETLQEVADKYGKTTA 218
Cdd:cd19106 160 RQIDDILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLgspdrpwakpDEPVLLEEPKVKALAKKYNKSPA 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 487996244 219 QIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHRV 270
Cdd:cd19106 240 QILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRY 291
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
9-271 |
1.31e-88 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 264.41 E-value: 1.31e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAgikeAGISREDLFITSKVWNADQ 88
Cdd:cd19134 4 TLNDDNTMPVIGLGVGELSDD-EAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAA----SGIPRGELFVTTKLATPDQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPV--EGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQ 166
Cdd:cd19134 79 GFTASQAACRASLERLGLDYVDLYLIHWPAgrEGKYVDSWGGLMKLREEGLARSIGVSNFTAEHLENLIDLTFFTPAVNQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 167 VEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANA 246
Cdd:cd19134 159 IELHPLLNQAELRKVNAQHGIVTQAYSPLGVGRLLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNL 238
|
250 260
....*....|....*....|....*
gi 487996244 247 NIFDFELTKEDMEKIDALNQNHRVG 271
Cdd:cd19134 239 DVFDFELTADHMDALDGLDDGTRFR 263
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
1-269 |
2.25e-87 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 262.35 E-value: 2.25e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 1 MKNLqsktTLHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFIT 80
Cdd:cd19123 1 MKTL----PLSNGDLIPALGLGTWKSKPG-EVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWIT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 81 SKVWNADQGYETTLAAYEESLKKLELDYLDLYLVHWPV-------------------EGKYKDSWRALETLYKEERVRAI 141
Cdd:cd19123 76 SKLWNNSHAPEDVLPALEKTLADLQLDYLDLYLMHWPValkkgvgfpesgedllslsPIPLEDTWRAMEELVDKGLCRHI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 142 GVSNFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQ------------LLDNETLQEV 209
Cdd:cd19123 156 GVSNFSVKKLEDLLATARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSGDrpaamkaegepvLLEDPVINKI 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 210 ADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHR 269
Cdd:cd19123 236 AEKHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHR 295
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
9-270 |
2.40e-87 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 261.90 E-value: 2.40e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQ 88
Cdd:cd19125 4 KLNTGAKIPAVGLGTWQADPG-VVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCTDH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPVEGK---------------YKDSWRALETLYKEERVRAIGVSNFQIHHLKD 153
Cdd:cd19125 83 APEDVPPALEKTLKDLQLDYLDLYLIHWPVRLKkgahmpepeevlppdIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLED 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 154 VLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL-------MQGQLLDNETLQEVADKYGKTTAQIILRWDL 226
Cdd:cd19125 163 LLAVARVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLgspgttwVKKNVLKDPIVTKVAEKLGKTPAQVALRWGL 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 487996244 227 QNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHRV 270
Cdd:cd19125 243 QRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRRV 286
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
16-262 |
3.20e-86 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 257.58 E-value: 3.20e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 16 MPWFGLGVFKVEdGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIragiKEAGISREDLFITSKVWNADQGYETTLA 95
Cdd:cd19073 1 IPALGLGTWQLR-GDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLRPEDLKK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AYEESLKKLELDYLDLYLVHWPVEGK-YKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQVEYHPRLT 174
Cdd:cd19073 76 SVDRSLEKLGTDYVDLLLIHWPNPTVpLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPIAVNQVEFHPFLY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 175 QKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELT 254
Cdd:cd19073 156 QAELLEYCRENDIVITAYSPLARGEVLRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELT 235
|
....*...
gi 487996244 255 KEDMEKID 262
Cdd:cd19073 236 SEDVAKID 243
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
11-264 |
4.38e-85 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 254.88 E-value: 4.38e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 11 HNGVEMPWFGLGVFKVEdGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAgikeAGISREDLFITSKVWNADQGY 90
Cdd:cd19140 3 VNGVRIPALGLGTYPLT-GEECTRAVEHALELGYRHIDTAQMYGNEAQVGEAIAA----SGVPRDELFLTTKVWPDNYSP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 91 ETTLAAYEESLKKLELDYLDLYLVHWP-VEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQVEY 169
Cdd:cd19140 78 DDFLASVEESLRKLRTDYVDLLLLHWPnKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPLFTNQVEY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 170 HPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNE-VVTIPKSTKEQRIIANANI 248
Cdd:cd19140 158 HPYLDQRKLLDAAREHGIALTAYSPLARGEVLKDPVLQEIGRKHGKTPAQVALRWLLQQEgVAAIPKATNPERLEENLDI 237
|
250
....*....|....*.
gi 487996244 249 FDFELTKEDMEKIDAL 264
Cdd:cd19140 238 FDFTLSDEEMARIAAL 253
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
9-270 |
8.23e-82 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 248.48 E-value: 8.23e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEdGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQ 88
Cdd:cd19154 5 TLSNGVKMPLIGLGTWQSK-GAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLWTHEH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWP-----VEGKYK---------------DSWRALETLYKEERVRAIGVSNFQI 148
Cdd:cd19154 84 APEDVEEALRESLKKLQLEYVDLYLIHAPaafkdDEGESGtmengmsihdavdveDVWRGMEKVYDEGLTKAIGVSNFNN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 149 HHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL---------------MQGQLLDNETLQEVADKY 213
Cdd:cd19154 164 DQIQRILDNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLgspgranftkstgvsPAPNLLQDPIVKAIAEKH 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 487996244 214 GKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHRV 270
Cdd:cd19154 244 GKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRL 300
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
9-265 |
3.95e-81 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 245.21 E-value: 3.95e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAgikeAGISREDLFITSKVWNADQ 88
Cdd:cd19130 3 VLNDGNSIPQLGYGVFKVPPA-DTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAA----SGIPRDELFVTTKLWNDRH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPV--EGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQ 166
Cdd:cd19130 78 DGDEPAAAFAESLAKLGLDQVDLYLVHWPTpaAGNYVHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPAVNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 167 VEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANA 246
Cdd:cd19130 158 IELHPAYQQRTIRDWAQAHDVKIEAWSPLGQGKLLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNL 237
|
250
....*....|....*....
gi 487996244 247 NIFDFELTKEDMEKIDALN 265
Cdd:cd19130 238 DVFDFDLTDTEIAAIDALD 256
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
12-266 |
9.13e-77 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 234.86 E-value: 9.13e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 12 NGVEMPWFGLGVFKVEDGPE-LVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGI-SREDLFITSKVWNADQG 89
Cdd:cd19124 1 SGQTMPVIGMGTASDPPSPEdIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVkSRDELFVTSKLWCSDAH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 90 YETTLAAYEESLKKLELDYLDLYLVHWPV---EGKY--------------KDSWRALETLYKEERVRAIGVSNFQIHHLK 152
Cdd:cd19124 81 PDLVLPALKKSLRNLQLEYVDLYLIHWPVslkPGKFsfpieeedflpfdiKGVWEAMEECQRLGLTKAIGVSNFSCKKLQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 153 DVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL-----MQG--QLLDNETLQEVADKYGKTTAQIILRWD 225
Cdd:cd19124 161 ELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLgapgtKWGsnAVMESDVLKEIAAAKGKTVAQVSLRWV 240
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 487996244 226 LQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQ 266
Cdd:cd19124 241 YEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKISEIPQ 281
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
13-269 |
6.23e-75 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 229.81 E-value: 6.23e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGV----FKVEDGP---ELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIragiKEAGISREDLFITSKVWN 85
Cdd:cd19120 1 GSKIPAIAFGTgtawYKSGDDDiqrDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEAL----KESGVPREDLFITTKVSP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 86 adqGYETTLAAYEESLKKLELDYLDLYLVHWPVEGKYKD-----SWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEI 160
Cdd:cd19120 77 ---GIKDPREALRKSLAKLGVDYVDLYLIHSPFFAKEGGptlaeAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 161 KPMINQVEYHPRLT--QKELQAFCKEQGIQMEAWSPL------MQGQLLDneTLQEVADKYGKTTAQIILRWDLQNEVVT 232
Cdd:cd19120 154 KPAVNQIEFHPYLYpqQPALLEYCREHGIVVSAYSPLspltrdAGGPLDP--VLEKIAEKYGVTPAQVLLRWALQKGIVV 231
|
250 260 270
....*....|....*....|....*....|....*..
gi 487996244 233 IPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHR 269
Cdd:cd19120 232 VTTSSKEERMKEYLEAFDFELTEEEVEEIDKAGKQKH 268
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
9-269 |
1.55e-72 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 225.06 E-value: 1.55e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQ 88
Cdd:cd19112 4 TLNSGHKMPVIGLGVWRMEPG-EIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWNSDH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYetTLAAYEESLKKLELDYLDLYLVHWPVEGKY------------------------KDSWRALETLYKEERVRAIGVS 144
Cdd:cd19112 83 GH--VIEACKDSLKKLQLDYLDLYLVHFPVATKHtgvgttgsalgedgvldidvtislETTWHAMEKLVSAGLVRSIGIS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 145 NFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQG----------QLLDNETLQEVADKYG 214
Cdd:cd19112 161 NYDIFLTRDCLAYSKIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGGAaanaewfgsvSPLDDPVLKDLAKKYG 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 487996244 215 KTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHR 269
Cdd:cd19112 241 KSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYR 295
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
10-264 |
5.75e-72 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 222.67 E-value: 5.75e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 10 LHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGI-SREDLFITSKVWNADQ 88
Cdd:cd19118 1 LNTGNKIPAIGLGTWQAEPG-EVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEEPGvKREDLFITSKLWNNSH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPV-------------------------EGKYKDSWRALETLYKEERVRAIGV 143
Cdd:cd19118 80 RPEYVEPALDDTLKELGLDYLDLYLIHWPVafkptgdlnpltavptnggevdldlSVSLVDTWKAMVELKKTGKVKSIGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 144 SNFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL---MQGQ--LLDNETLQEVADKYGKTTA 218
Cdd:cd19118 160 SNFSIDHLQAIIEETGVVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLgnnLAGLplLVQHPEVKAIAAKLGKTPA 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 487996244 219 QIILRWDLQNEVVTIPKSTKEQRIiaNANIFDFELTKEDMEKIDAL 264
Cdd:cd19118 240 QVLIAWGIQRGHSVIPKSVTPSRI--RSNFEQVELSDDEFNAVTAL 283
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
9-269 |
1.47e-71 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 222.32 E-value: 1.47e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVeDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQ 88
Cdd:cd19113 4 KLNSGYKMPSVGFGCWKL-DNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWNNFH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPV-------EGKYK-------------------DSWRALETLYKEERVRAIG 142
Cdd:cd19113 83 DPKNVETALNKTLSDLKLDYVDLFLIHFPIafkfvpiEEKYPpgfycgdgdnfvyedvpilDTWKALEKLVDAGKIKSIG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 143 VSNFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSP--------LMQGQ------LLDNETLQE 208
Cdd:cd19113 163 VSNFPGALILDLLRGATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSfgpqsfveLNQGRalntptLFEHDTIKS 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487996244 209 VADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHR 269
Cdd:cd19113 243 IAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLR 303
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
6-268 |
7.80e-71 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 219.68 E-value: 7.80e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 6 SKT-TLHNGVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAgikeAGISREDLFITSKVW 84
Cdd:cd19117 3 SKTfKLNTGAEIPAVGLGTWQSKPN-EVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIKD----SGVPREEIFITTKLW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 85 NADQgyETTLAAYEESLKKLELDYLDLYLVHWPV----------------------EGKYKDSWRALETLYKEERVRAIG 142
Cdd:cd19117 78 CTWH--RRVEEALDQSLKKLGLDYVDLYLMHWPVpldpdgndflfkkddgtkdhepDWDFIKTWELMQKLPATGKVKAIG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 143 VSNFQIHHLKDVL--EGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL--MQGQLLDNETLQEVADKYGKTTA 218
Cdd:cd19117 156 VSNFSIKNLEKLLasPSAKIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLgsTNAPLLKEPVIIKIAKKHGKTPA 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 487996244 219 QIILRWDLQNEVVTIPKSTKEQRIIANANIfdFELTKEDMEKIDALNQNH 268
Cdd:cd19117 236 QVIISWGLQRGYSVLPKSVTPSRIESNFKL--FTLSDEEFKEIDELHKEY 283
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
13-270 |
3.06e-70 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 218.83 E-value: 3.06e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQGYET 92
Cdd:cd19107 1 GAKMPILGLGTWKSPPG-QVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 93 TLAAYEESLKKLELDYLDLYLVHWPV--------------------EGKYKDSWRALETLYKEERVRAIGVSNFQIHHLK 152
Cdd:cd19107 80 VKGACQKTLSDLKLDYLDLYLIHWPTgfkpgkelfpldesgnvipsDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 153 DVLE--GAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL----------MQGQLLDNETLQEVADKYGKTTAQI 220
Cdd:cd19107 160 RILNkpGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLgspdrpwakpEDPSLLEDPKIKEIAAKHNKTTAQV 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 487996244 221 ILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHRV 270
Cdd:cd19107 240 LIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRA 289
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
13-269 |
1.16e-69 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 216.98 E-value: 1.16e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGVFKVEdGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQGYET 92
Cdd:cd19111 1 GFPMPVIGLGTYQSP-PEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEFKD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 93 TLAAYEESLKKLELDYLDLYLVHWPVEGKYKDS--------------WRALETLYKEERVRAIGVSNFQIHHLKDVLEGA 158
Cdd:cd19111 80 TEKSLEKSLENLKLPYVDLYLIHHPCGFVNKKDkgerelassdvtsvWRAMEALVSEGKVKSIGLSNFNPRQINKILAYA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 159 EIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL------------MQGQLLDNETLQEVADKYGKTTAQIILRWDL 226
Cdd:cd19111 160 KVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLgspgranqslwpDQPDLLEDPTVLAIAKELDKTPAQVLLRFVL 239
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 487996244 227 QNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHR 269
Cdd:cd19111 240 QRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMK 282
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
7-277 |
1.64e-69 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 217.29 E-value: 1.64e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 7 KTTLHNGVEMPWFGLGVFKVeDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNA 86
Cdd:cd19115 4 TVKLNSGYDMPLVGFGLWKV-NNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLWNT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 87 DQGYETTLAAYEESLKKLELDYLDLYLVHWPVEGKYKD-------------------------SWRALETLYKEERVRAI 141
Cdd:cd19115 83 FHDGERVEPICRKQLADWGIDYFDLFLIHFPIALKYVDpavryppgwfydgkkvefsnapiqeTWTAMEKLVDKGLARSI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 142 GVSNFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWS---PL------MQGQ-----LLDNETLQ 207
Cdd:cd19115 163 GVSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSsfgPQsfleldLPGAkdtppLFEHDVIK 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 208 EVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHRVGpDPDNF 277
Cdd:cd19115 243 SIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRFN-NPLNY 311
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
15-274 |
6.40e-69 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 215.59 E-value: 6.40e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 15 EMPWFGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQGYETTL 94
Cdd:cd19110 3 DIPAVGLGTWKASPG-EVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLVK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 95 AAYEESLKKLELDYLDLYLVHWPVEGK--------------------YKDSWRALETLYKEERVRAIGVSNFQIHHLKDV 154
Cdd:cd19110 82 TACTRSLKALKLNYLDLYLIHWPMGFKpgepdlpldrsgmvipsdtdFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLERL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 155 LE--GAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL---MQG-QLLDNETLQEVADKYGKTTAQIILRWDLQN 228
Cdd:cd19110 162 LNkpGLRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLggsCEGvDLIDDPVIQRIAKKHGKSPAQILIRFQIQR 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 487996244 229 EVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHRVGPDP 274
Cdd:cd19110 242 NVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFP 287
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
9-264 |
2.21e-68 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 213.16 E-value: 2.21e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKvEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIkEAGISREDLFITSKVWNAdq 88
Cdd:cd19121 5 KLNTGASIPAVGLGTWQ-AKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAI-AGGVKREDLFVTTKLWST-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 gYETTL-AAYEESLKKLELDYLDLYLVHWPV---------------EGK--------YKDSWRALETLYKEERVRAIGVS 144
Cdd:cd19121 81 -YHRRVeLCLDRSLKSLGLDYVDLYLVHWPVllnpngnhdlfptlpDGSrdldwdwnHVDTWKQMEKVLKTGKTKAIGVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 145 NFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL--MQGQLLDNETLQEVADKYGKTTAQIIL 222
Cdd:cd19121 160 NYSIPYLEELLKHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLgsTGSPLISDEPVVEIAKKHNVGPGTVLI 239
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 487996244 223 RWDLQNEVVTIPKSTKEQRIIANANIFDFelTKEDMEKIDAL 264
Cdd:cd19121 240 SYQVARGAVVLPKSVTPDRIKSNLEIIDL--DDEDMNKLNDI 279
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
10-272 |
1.17e-66 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 209.78 E-value: 1.17e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 10 LHNGVEMPWFGLGVFKVEDGP--ELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNAD 87
Cdd:cd19108 5 LNDGHFIPVLGFGTYAPEEVPksKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKLWCTF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 88 QGYETTLAAYEESLKKLELDYLDLYLVHWPV-------------EGK-------YKDSWRALETLYKEERVRAIGVSNFQ 147
Cdd:cd19108 85 HRPELVRPALEKSLKKLQLDYVDLYLIHFPValkpgeelfpkdeNGKlifdtvdLCATWEAMEKCKDAGLAKSIGVSNFN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 148 IHHLKDVLE--GAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLmqGQ-------------LLDNETLQEVADK 212
Cdd:cd19108 165 RRQLEMILNkpGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSAL--GSqrdkewvdqnspvLLEDPVLCALAKK 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 213 YGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHRVGP 272
Cdd:cd19108 243 HKRTPALIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLRYLP 302
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
10-264 |
2.84e-65 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 205.81 E-value: 2.84e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 10 LHNGVEMPWFGLGVFK-VEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNAdq 88
Cdd:cd19119 6 LNTGASIPALGLGTASpHEDRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWPT-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWPV--------------------------EGKYKDSWRALETLYKEERVRAIG 142
Cdd:cd19119 84 FYDEVERSLDESLKALGLDYVDLLLVHWPVcfekdsddsgkpftpvnddgktryaaSGDHITTYKQLEKIYLDGRAKAIG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 143 VSNFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL--MQGQLLDNETLQEVADKYGKTTAQI 220
Cdd:cd19119 164 VSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLgsHGAPNLKNPLVKKIAEKYNVSTGDI 243
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 487996244 221 ILRWDLQNEVVTIPKSTKEQRIIANANIfdFELTKEDMEKIDAL 264
Cdd:cd19119 244 LISYHVRQGVIVLPKSLKPVRIVSNGKI--VSLTKEDLQKLDDI 285
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
16-264 |
3.70e-64 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 201.43 E-value: 3.70e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 16 MPWFGLGVFKVEDgPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRagikEAGISREDLFITSKVWNADQGYETTLA 95
Cdd:cd19139 1 IPAFGLGTFRLKD-DVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKIWIDNLSKDKLLP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AYEESLKKLELDYLDLYLVHWP---VEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLE--GAEiKPMINQVEYH 170
Cdd:cd19139 76 SLEESLEKLRTDYVDLTLIHWPspnDEVPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAvvGAG-AIATNQIELS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 171 PRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFD 250
Cdd:cd19139 155 PYLQNRKLVAHCKQHGIHVTSYMTLAYGKVLDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALD 234
|
250
....*....|....
gi 487996244 251 FELTKEDMEKIDAL 264
Cdd:cd19139 235 LTLDADDMAAIAAL 248
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
5-269 |
8.58e-64 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 202.37 E-value: 8.58e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 5 QSKTTLHNGVEMPWFGLGVFKVEdgPELVE-AVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKV 83
Cdd:cd19155 1 RNCVTFNNGEKMPVVGLGTWQSS--PEEIEtAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 84 ---WNADQGYETTLAAyeeSLKKLELDYLDLYLVHWPVEGKYK----------------------DSWRALETLYKEERV 138
Cdd:cd19155 79 ppgGNRREKVEKFLLK---SLEKLQLDYVDLYLIHFPVGSLSKeddsgkldptgehkqdyttdllDIWKAMEAQVDQGLT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 139 RAIGVSNFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL-----------------MQGQLL 201
Cdd:cd19155 156 RSIGLSNFNREQMARILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLgspgaahfspgtgspsgSSPDLL 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487996244 202 DNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHR 269
Cdd:cd19155 236 QDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIR 303
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
16-273 |
1.48e-63 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 200.64 E-value: 1.48e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 16 MPWFGLGVFKVEDGPeLVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRagikEAGISREDLFITSKVWNADQGYETTLA 95
Cdd:PRK11172 3 IPAFGLGTFRLKDQV-VIDSVKTALELGYRAIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKIWIDNLAKDKLIP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AYEESLKKLELDYLDLYLVHWPVEGKYKDSWRALETLYKEER---VRAIGVSNFQIHHLK---DVLEGAEIKpmINQVEY 169
Cdd:PRK11172 78 SLKESLQKLRTDYVDLTLIHWPSPNDEVSVEEFMQALLEAKKqglTREIGISNFTIALMKqaiAAVGAENIA--TNQIEL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 170 HPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIF 249
Cdd:PRK11172 156 SPYLQNRKVVAFAKEHGIHVTSYMTLAYGKVLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNLLAQ 235
|
250 260
....*....|....*....|....*
gi 487996244 250 DFELTKEDMEKIDALNQNHR-VGPD 273
Cdd:PRK11172 236 DLQLDAEDMAAIAALDRNGRlVSPE 260
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
13-269 |
3.19e-63 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 200.86 E-value: 3.19e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGVFKVeDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQGYET 92
Cdd:cd19114 1 GDKMPLVGFGTAKI-KANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGKDH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 93 TLAAYEESLKKLELDYLDLYLVHWPVEGKY--------------------------KDSWRALETLYKEERVRAIGVSNF 146
Cdd:cd19114 80 VREAFDRQLKDYGLDYIDLYLIHFPIPAAYvdpaenypflwkdkelkkfpleqspmQECWREMEKLVDAGLVRNIGIANF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 147 QIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQG-------------QLLDNETLQEVADKY 213
Cdd:cd19114 160 NVQLILDLLTYAKIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGNAvytkvtkhlkhftNLLEHPVVKKLADKH 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 487996244 214 GKTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHR 269
Cdd:cd19114 240 KRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANAR 295
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
13-269 |
1.02e-61 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 197.33 E-value: 1.02e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGVFKVEDGP---ELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQG 89
Cdd:cd19109 1 GNSIPIIGLGTYSEPKTTpkgACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 90 YETTLAAYEESLKKLELDYLDLYLVHWPV-------------EGKYK-------DSWRALETLYKEERVRAIGVSNFQIH 149
Cdd:cd19109 81 PELVRPTLERTLKVLQLDYVDLYIIEMPMafkpgdeiyprdeNGKWLyhktnlcATWEALEACKDAGLVKSIGVSNFNRR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 150 HLKDVLE--GAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQ-----------LLDNETLQEVADKYGKT 216
Cdd:cd19109 161 QLELILNkpGLKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRdpiwvnvssppLLEDPLLNSIGKKYNKT 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 487996244 217 TAQIILRWDLQNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDALNQNHR 269
Cdd:cd19109 241 AAQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVR 293
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
9-264 |
8.73e-61 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 194.38 E-value: 8.73e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 9 TLHNGVEMPWFGLGVFKVEDGP-ELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKE-AGISREDLFITSKVWNA 86
Cdd:cd19122 2 TLNNGVKIPAVGFGTFANEGAKgETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKEnPSVKREDLFICTKVWNH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 87 DQGYETTLAAYEESLKKLELDYLDLYLVHWPV--------------EGKY----------KDSWRALETLYKEERVRAIG 142
Cdd:cd19122 82 LHEPEDVKWSIDNSLKNLKLDYIDLFLVHWPIaaekndqrspklgpDGKYvilkdltenpEPTWRAMEEIYESGKAKAIG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 143 VSNFQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL-MQGQ-------LLDNETLQEVADKYG 214
Cdd:cd19122 162 VSNWTIPGLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLgSQNQvpstgerVSENPTLNEVAEKGG 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 487996244 215 KTTAQIILRWDLQNEVVTIPKSTKEQRIIANANIfdFELTKEDMEKIDAL 264
Cdd:cd19122 242 YSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKS--IELSDEDFEAINQV 289
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
17-264 |
8.22e-59 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 188.89 E-value: 8.22e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 17 PWFGLGVFKVEDgPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQGYETTLAA 96
Cdd:cd19128 2 PRLGFGTYKITE-SESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVKEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 97 YEESLKKLELDYLDLYLVHWPVE------------------GKY--KDSWRALETLYKEERVRAIGVSNFQIHHLKDVLE 156
Cdd:cd19128 81 LLITLQDLQLEYLDLFLIHWPLAfdmdtdgdprddnqiqslSKKplEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 157 GAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNET------LQEVADKYGKTTAQIILRWDLQ--- 227
Cdd:cd19128 161 YCKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLGGSYGDGNLTflndseLKALATKYNTTPPQVIIAWHLQkwp 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 487996244 228 NEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDAL 264
Cdd:cd19128 241 KNYSVIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
13-262 |
9.95e-57 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 182.81 E-value: 9.95e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGVFKV--------EDGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRagikeaGISREDLFITS 81
Cdd:cd19072 1 GEEVPVLGLGTWGIgggmskdySDDKKAIEALRYAIELGINLIDTAEMYGGghaEELVGKAIK------GFDREDLFITT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 82 KVWNADQGYETTLAAYEESLKKLELDYLDLYLVHWPV-EGKYKDSWRALETLYKEERVRAIGVSNF---QIHHLKDVLEG 157
Cdd:cd19072 75 KVSPDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNpSIPIEETLRAMEELVEEGKIRYIGVSNFsleELEEAQSYLKK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 158 AEIkpMINQVEYH--PRLTQKELQAFCKEQGIQMEAWSPLMQGQLL---DNETLQEVADKYGKTTAQIILRWDLQNE-VV 231
Cdd:cd19072 155 GPI--VANQVEYNlfDREEESGLLPYCQKNGIAIIAYSPLEKGKLSnakGSPLLDEIAKKYGKTPAQIALNWLISKPnVI 232
|
250 260 270
....*....|....*....|....*....|.
gi 487996244 232 TIPKSTKEQRIIANANIFDFELTKEDMEKID 262
Cdd:cd19072 233 AIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
11-262 |
3.72e-53 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 174.57 E-value: 3.72e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 11 HNGVEMPWFGLGVFkVEDGPELVEAVKVAIKEGYRSIDTAAIYGNEKAVGEGIRAGIKEAGISREDLFITSKVWNADQGY 90
Cdd:cd19129 1 NGSGAIPALGFGTL-IPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNHRP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 91 ETTLAAYEESLKKLELDYLDLYLVHWPV--------------------EG-KYKDSWRALETLYKEERVRAIGVSNFQIH 149
Cdd:cd19129 80 ERVKPAFEASLKRLQLDYLDLYLIHTPFafqpgdeqdprdangnviydDGvTLLDTWRAMERLVDEGRCKAIGLSDVSLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 150 HLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPL---MQGQLLDNETLQEVADKYGKTTAQIILRWDL 226
Cdd:cd19129 160 KLREIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLghgMEPKLLEDPVITAIARRVNKTPAQVLLAWAI 239
|
250 260 270
....*....|....*....|....*....|....*..
gi 487996244 227 QNEVVTIPKSTKEQRIIANaniFDFELTKED-MEKID 262
Cdd:cd19129 240 QRGTALLTTSKTPSRIREN---FDISTLPEDaMREIN 273
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
7-262 |
3.82e-52 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 171.28 E-value: 3.82e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 7 KTTLHNGVEMPWFGLGVFKVEDGPEL----VEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAgikeagiSREDLFI 79
Cdd:cd19138 2 TVTLPDGTKVPALGQGTWYMGEDPAKraqeIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRG-------RRDKVFL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 80 TSKV--WNAdqGYETTLAAYEESLKKLELDYLDLYLVHWPVEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEG 157
Cdd:cd19138 75 VSKVlpSNA--SRQGTVRACERSLRRLGTDYLDLYLLHWRGGVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 158 AEIKPM-INQVEYH--PRLTQKELQAFCKEQGIQMEAWSPLMQGQLLD-----NETLQEVADKYGKTTAQIILRWDL-QN 228
Cdd:cd19138 153 PGGGNCaANQVLYNlgSRGIEYDLLPWCREHGVPVMAYSPLAQGGLLRrglleNPTLKEIAARHGATPAQVALAWVLrDG 232
|
250 260 270
....*....|....*....|....*....|....
gi 487996244 229 EVVTIPKSTKEQRIIANANIFDFELTKEDMEKID 262
Cdd:cd19138 233 NVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
13-262 |
6.16e-48 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 160.04 E-value: 6.16e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGVFKV--------EDGPELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIRagikeaGISREDLFITS 81
Cdd:cd19137 1 GEKIPALGLGTWGIggfltpdySRDEEMVELLKTAIELGYTHIDTAEMYGgghTEELVGKAIK------DFPREDLFIVT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 82 KVWNADQGYETTLAAYEESLKKLELDYLDLYLVHWP-VEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEI 160
Cdd:cd19137 75 KVWPTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWPnPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 161 KPMINQVEYH---PRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQNE-VVTIPKS 236
Cdd:cd19137 155 PIVCNQVKYNledRDPERDGLLEYCQKNGITVVAYSPLRRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQKPnVVAIPKA 234
|
250 260
....*....|....*....|....*.
gi 487996244 237 TKEQRIIANANIFDFELTKEDMEKID 262
Cdd:cd19137 235 GRVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
30-265 |
1.57e-47 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 160.17 E-value: 1.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 30 PELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIragiKEAGISREDLFITSKVWNADQGY------ETTLAAYEES 100
Cdd:pfam00248 18 EEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVPDGDGPWpsggskENIRKSLEES 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 101 LKKLELDYLDLYLVHWP-VEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQVEYHP--RLTQKE 177
Cdd:pfam00248 94 LKRLGTDYIDLYYLHWPdPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLlrRRQEEE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 178 LQAFCKEQGIQMEAWSPLMQG---------------------------QLLDNETLQEVADKYGKTTAQIILRWDLQNEV 230
Cdd:pfam00248 174 LLEYCKKNGIPLIAYSPLGGGlltgkytrdpdkgpgerrrllkkgtplNLEALEALEEIAKEHGVSPAQVALRWALSKPG 253
|
250 260 270
....*....|....*....|....*....|....*..
gi 487996244 231 VT--IPKSTKEQRIIANANIFDFELTKEDMEKIDALN 265
Cdd:pfam00248 254 VTipIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
31-263 |
1.07e-36 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 131.94 E-value: 1.07e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 31 ELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAgikeagiSREDLFITSKVWNADQGYETTLAAYEESLKKLELD 107
Cdd:cd19085 24 ESIATIHAALDAGINFFDTAEAYGDghsEEVLGKALKG-------RRDDVVIATKVSPDNLTPEDVRKSCERSLKRLGTD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 108 YLDLYLVHWPVEG-KYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKpmINQVEYHP--RLTQKELQAFCKE 184
Cdd:cd19085 97 YIDLYQIHWPSSDvPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAGRID--SNQLPYNLlwRAIEYEILPFCRE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 185 QGIQMEAWSPLMQGqLL-------------DNET--------------------LQEVADKYGKTTAQIILRWDLQNEVV 231
Cdd:cd19085 175 HGIGVLAYSPLAQG-LLtgkfssaedfppgDARTrlfrhfepgaeeetfealekLKEIADELGVTMAQLALAWVLQQPGV 253
|
250 260 270
....*....|....*....|....*....|....
gi 487996244 232 T--IPKSTKEQRIIANANIFDFELTKEDMEKIDA 263
Cdd:cd19085 254 TsvIVGARNPEQLEENAAAVDLELSPSVLERLDE 287
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
31-262 |
1.23e-34 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 126.49 E-value: 1.23e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 31 ELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIragikeAGIsREDLFITSKV---WNADQGY------ETTLAAYE 98
Cdd:cd19084 26 ESIEAIKAAIDLGINFFDTAPVYGFghsEEILGKAL------KGR-RDDVVIATKCglrWDGGKGVtkdlspESIRKEVE 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 99 ESLKKLELDYLDLYLVHW-----PVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIkpMINQVEYHP-- 171
Cdd:cd19084 99 QSLRRLQTDYIDLYQIHWpdpntPIE----ETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKYGPI--VSLQPPYSMle 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 172 RLTQKELQAFCKEQGIQMEAWSPLMQGQL---LDNET----------------------------LQEVADKYGKTTAQI 220
Cdd:cd19084 173 REIEEELLPYCRENGIGVLPYGPLAQGLLtgkYKKEPtfppddrrsrfpffrgenfeknleivdkLKEIAEKYGKSLAQL 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 487996244 221 ILRWDLQNEVVT--IPKSTKEQRIIANANIFDFELTKEDMEKID 262
Cdd:cd19084 253 AIAWTLAQPGVTsaIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
30-262 |
1.41e-34 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 126.19 E-value: 1.41e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 30 PELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAGIKeagisREDLFITSKVWNA--DQGYETTLAAYEESLKKL 104
Cdd:cd19093 26 EDLQAAFDAALEAGVNLFDTAEVYGTgrsERLLGRFLKELGD-----RDEVVIATKFAPLpwRLTRRSVVKALKASLERL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 105 ELDYLDLYLVHWPVEGKYKDS--WRALETLYKEERVRAIGVSNFQIHHLKDV---LEGAEIKPMINQVEY---HPRLTQK 176
Cdd:cd19093 101 GLDSIDLYQLHWPGPWYSQIEalMDGLADAVEEGLVRAVGVSNYSADQLRRAhkaLKERGVPLASNQVEYsllYRDPEQN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 177 ELQAFCKEQGIQMEAWSPLMQGQL-----LDN----------------------ETLQEVADKYGKTTAQIILRWDLQNE 229
Cdd:cd19093 181 GLLPACDELGITLIAYSPLAQGLLtgkysPENpppggrrrlfgrknlekvqpllDALEEIAEKYGKTPAQVALNWLIAKG 260
|
250 260 270
....*....|....*....|....*....|...
gi 487996244 230 VVTIPKSTKEQRIIANANIFDFELTKEDMEKID 262
Cdd:cd19093 261 VVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
19-274 |
5.22e-34 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 125.29 E-value: 5.22e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 19 FGLGVFKVEDGpELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIRagikeaGISREDLFITSKV--------WNAD 87
Cdd:COG0667 23 FGGPWGGVDEA-EAIAILDAALDAGINFFDTADVYGpgrSEELLGEALK------GRPRDDVVIATKVgrrmgpgpNGRG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 88 QGYETTLAAYEESLKkleldyldlyLVHW-----PVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKP 162
Cdd:COG0667 96 LSREHIRRAVEASLRrlgtdyidlyQLHRpdpdtPIE----ETLGALDELVREGKIRYIGVSNYSAEQLRRALAIAEGLP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 163 MI--NQVEYHP--RLTQKELQAFCKEQGIQMEAWSPLMQGQLLDN------------------------------ETLQE 208
Cdd:COG0667 172 PIvaVQNEYSLldRSAEEELLPAARELGVGVLAYSPLAGGLLTGKyrrgatfpegdraatnfvqgylternlalvDALRA 251
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 487996244 209 VADKYGKTTAQIILRWDLQNEVVT--IPKSTKEQRIIANANIFDFELTKEDMEKIDALnqnHRVGPDP 274
Cdd:COG0667 252 IAAEHGVTPAQLALAWLLAQPGVTsvIPGARSPEQLEENLAAADLELSAEDLAALDAA---LAAVPAP 316
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
18-264 |
1.28e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 102.75 E-value: 1.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 18 WFGLGVfkvEDGPELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIRAgikeagiSREDLFITSK---VWNAD---- 87
Cdd:cd19102 17 GGGWGP---QDDRDSIAAIRAALDLGINWIDTAAVYGlghSEEVVGRALKG-------LRDRPIVATKcglLWDEEgrir 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 88 QGY--ETTLAAYEESLKKLELDYLDLYLVHWPV-EGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEI---K 161
Cdd:cd19102 87 RSLkpASIRAECEASLRRLGVDVIDLYQIHWPDpDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHPIaslQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 162 PMINQVEyhpRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDN---------------------------------ETLQE 208
Cdd:cd19102 167 PPYSLLR---RGIEAEILPFCAEHGIGVIVYSPMQSGLLTGKmtpervaslpaddwrrrspffqepnlarnlalvDALRP 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 487996244 209 VADKYGKTTAQIILRWDLQNEVVT--IPKSTKEQRIIANANIFDFELTKEDMEKIDAL 264
Cdd:cd19102 244 IAERHGRTVAQLAIAWVLRRPEVTsaIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
11-257 |
4.69e-25 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 100.71 E-value: 4.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 11 HNGVEMPWFGLGVFKVEDGP----ELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIragiKEAGISREDLFITSK- 82
Cdd:cd19092 1 PEGLEVSRLVLGCMRLADWGesaeELLSLIEAALELGITTFDHADIYGGgkcEELFGEAL----ALNPGLREKIEIQTKc 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 83 ---VWNADQG-----YETT----LAAYEESLKKLELDYLDLYLVHWP---VEgkYKDSWRALETLYKEERVRAIGVSNFQ 147
Cdd:cd19092 77 girLGDDPRPgrikhYDTSkehiLASVEGSLKRLGTDYLDLLLLHRPdplMD--PEEVAEAFDELVKSGKVRYFGVSNFT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 148 IHHLkDVLEGA-EIKPMINQVE---YHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLD---------NETLQEVADKYG 214
Cdd:cd19092 155 PSQI-ELLQSYlDQPLVTNQIElslLHTEAIDDGTLDYCQLLDITPMAWSPLGGGRLFGgfderfqrlRAALEELAEEYG 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 487996244 215 KTTAQIILRWDLQN--EVVTIPKSTKEQRIIANANIFDFELTKED 257
Cdd:cd19092 234 VTIEAIALAWLLRHpaRIQPILGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
28-234 |
6.72e-24 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 96.43 E-value: 6.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 28 DGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAGIKeagisREDLFITSKVWNADQGY--------ETTLAA 96
Cdd:cd06660 15 DEEEAFALLDAALEAGGNFFDTADVYGDgrsERLLGRWLKGRGN-----RDDVVIATKGGHPPGGDpsrsrlspEHIRRD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 97 YEESLKKLELDYLDLYLVHW-----PVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAE----IKPMINQV 167
Cdd:cd06660 90 LEESLRRLGTDYIDLYYLHRddpstPVE----ETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKahglPGFAAVQP 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 168 EY---HPRLTQKELQAFCKEQGIQMEAWSPLMQGqlldnetlqevadkygktTAQIILRWDLQNEVVTIP 234
Cdd:cd06660 166 QYsllDRSPMEEELLDWAEENGLPLLAYSPLARG------------------PAQLALAWLLSQPFVTVP 217
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
27-264 |
5.04e-22 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 93.25 E-value: 5.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 27 EDGPELVeavKVAIKEGYRSIDTAAIYG---NEKAVGEGIRagikeaGISREDLFITSKVWNADQGYETTL--------A 95
Cdd:cd19083 33 EEGKDLV---REALDNGVNLLDTAFIYGlgrSEELVGEVLK------EYNRNEVVIATKGAHKFGGDGSVLnnspeflrS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AYEESLKKLELDYLDLYLVHWPVEGKYKD-SWRALETLYKEERVRAIGVSNFQIHHLK--------DVLEGaeikpminq 166
Cdd:cd19083 104 AVEKSLKRLNTDYIDLYYIHFPDGETPKAeAVGALQELKDEGKIRAIGVSNFSLEQLKeankdgyvDVLQG--------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 167 vEYHprLTQKELQA----FCKEQGIQMEAWSPLMQGQL--------------LDNET-----------------LQEVAD 211
Cdd:cd19083 175 -EYN--LLQREAEEdilpYCVENNISFIPYFPLASGLLagkytkdtkfpdndLRNDKplfkgerfsenldkvdkLKSIAD 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 487996244 212 KYGKTTAQIILRWDLQNEVVT--IPKSTKEQRIIANANIFDFELTKEDMEKIDAL 264
Cdd:cd19083 252 EKGVTVAHLALAWYLTRPAIDvvIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
28-263 |
5.27e-22 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 93.11 E-value: 5.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 28 DGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAgikeagiSREDLFITSK---VWNADQGYE------TTLA 95
Cdd:cd19149 31 DDNESIRTIHAALDLGINLIDTAPAYGFghsEEIVGKAIKG-------RRDKVVLATKcglRWDREGGSFffvrdgVTVY 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AY----------EESLKKLELDYLDLYLVHWP-VEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKpmI 164
Cdd:cd19149 104 KNlspesireevEQSLKRLGTDYIDLYQTHWQdVETPIEETMEALEELKRQGKIRAIGASNVSVEQIKEYVKAGQLD--I 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 165 NQVEYH--PRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDN-------------------------------ETLQEVAD 211
Cdd:cd19149 182 IQEKYSmlDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTGKitpdrefdagdarsgipwfspenrekvlallEKWKPLCE 261
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 487996244 212 KYGKTTAQIILRWDLQ--NEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDA 263
Cdd:cd19149 262 KYGCTLAQLVIAWTLAqpGITSALCGARKPEQAEENAKAGDIRLSAEDIATMRS 315
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
25-263 |
9.63e-22 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 92.27 E-value: 9.63e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 25 KVEDGPELVEAVKVAIKEGYRSIDTAAIYGN-EKAVGEgIRAGIKEAGISREDLFITSKvWNADQGYETTLAAY-----E 98
Cdd:cd19101 18 GIRDEDAAVRAMAAYVDAGLTTFDCADIYGPaEELIGE-FRKRLRRERDAADDVQIHTK-WVPDPGELTMTRAYveaaiD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 99 ESLKKLELDYLDLYLVHW--PVEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEgAEIKPMINQVEYH--PRLT 174
Cdd:cd19101 96 RSLKRLGVDRLDLVQFHWwdYSDPGYLDAAKHLAELQEEGKIRHLGLTNFDTERLREILD-AGVPIVSNQVQYSllDRRP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 175 QKELQAFCKEQGIQMEAWSPLMQG---------------------------------------QLLdnETLQEVADKYGK 215
Cdd:cd19101 175 ENGMAALCEDHGIKLLAYGTLAGGllsekylgvpeptgpaletrslqkyklmidewggwdlfqELL--RTLKAIADKHGV 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 487996244 216 TTAQIILRWDLQNEVV--TIPKSTKEQRIIANANIFDFELTKEDMEKIDA 263
Cdd:cd19101 253 SIANVAVRWVLDQPGVagVIVGARNSEHIDDNVRAFSFRLDDEDRAAIDA 302
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
16-254 |
6.39e-19 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 83.42 E-value: 6.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 16 MPWFGLGVFKV-EDGPELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIRAgikeagiSREDLFITSKV-------- 83
Cdd:cd19088 9 MRLTGPGIWGPpADREEAIAVLRRALELGVNFIDTADSYGpdvNERLIAEALHP-------YPDDVVIATKGglvrtgpg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 84 -WNADQGYETTLAAYEESLKKLELDYLDLYLVHWP-VEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIK 161
Cdd:cd19088 82 wWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIdPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIVRIV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 162 PMINQveYHPRLTQKE-LQAFCKEQGIQMEAWSPLMQGQLLDNET-LQEVADKYGKTTAQIILRWDLQ--NEVVTIPKST 237
Cdd:cd19088 162 SVQNR--YNLANRDDEgVLDYCEAAGIAFIPWFPLGGGDLAQPGGlLAEVAARLGATPAQVALAWLLArsPVMLPIPGTS 239
|
250
....*....|....*..
gi 487996244 238 KEQRIIANANIFDFELT 254
Cdd:cd19088 240 SVEHLEENLAAAGLRLS 256
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
13-264 |
8.06e-19 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 84.20 E-value: 8.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFG-LGVFKVEDGPELVeavKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAgikeagiSREDLFITSKVWNA-- 86
Cdd:cd19091 24 GGGGGFFGaWGGVDQEEADRLV---DIALDAGINFFDTADVYSEgesEEILGKALKG-------RRDDVLIATKVRGRmg 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 87 ----DQG--YETTLAAYEESLKKLELDYLDLYLVHW-----PVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVL 155
Cdd:cd19091 94 egpnDVGlsRHHIIRAVEASLKRLGTDYIDLYQLHGfdaltPLE----ETLRALDDLVRQGKVRYIGVSNFSAWQIMKAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 156 EGAE----IKPMINQVEYHP--RLTQKELQAFCKEQGIQMEAWSPLMQGQL-------------------------LDNE 204
Cdd:cd19091 170 GISErrglARFVALQAYYSLlgRDLEHELMPLALDQGVGLLVWSPLAGGLLsgkyrrgqpapegsrlrrtgfdfppVDRE 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 487996244 205 -------TLQEVADKYGKTTAQIILRWDLQNEVVT--IPKSTKEQRIIANANIFDFELTKEDMEKIDAL 264
Cdd:cd19091 250 rgydvvdALREIAKETGATPAQVALAWLLSRPTVSsvIIGARNEEQLEDNLGAAGLSLTPEEIARLDKV 318
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
28-264 |
1.04e-18 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 83.90 E-value: 1.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 28 DGPELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIragiKEAGIsREDLFITSKV---WNADQGY------ETTLA 95
Cdd:cd19148 23 DEKEAIETIHKALDLGINLIDTAPVYGfglSEEIVGKAL----KEYGK-RDRVVIATKVgleWDEGGEVvrnsspARIRK 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AYEESLKKLELDYLDLYLVHWPVEGK-YKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEI---KPMINQVEyhp 171
Cdd:cd19148 98 EVEDSLRRLQTDYIDLYQVHWPDPLVpIEETAEALKELLDEGKIRAIGVSNFSPEQMETFRKVAPLhtvQPPYNLFE--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 172 RLTQKELQAFCKEQGIQMEAWSPLMQGQL--------------LDN-----------------ETLQEVA-DKYGKTTAQ 219
Cdd:cd19148 175 REIEKDVLPYARKHNIVTLAYGALCRGLLsgkmtkdtkfegddLRRtdpkfqeprfsqylaavEELDKLAqERYGKSVIH 254
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 487996244 220 IILRWDLQNEVVTIP--KSTKEQRIIANANIFDFELTKEDMEKIDAL 264
Cdd:cd19148 255 LAVRWLLDQPGVSIAlwGARKPEQLDAVDEVFGWSLNDEDMKEIDAI 301
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
36-259 |
1.61e-18 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 83.40 E-value: 1.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 36 VKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAGIKeagisREDLFITSKVWNA------DQGY--ETTLAAYEESLKKL 104
Cdd:cd19079 41 IKRALDLGINFFDTANVYSGgasEEILGRALKEFAP-----RDEVVIATKVYFPmgdgpnGRGLsrKHIMAEVDASLKRL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 105 ELDYLDLYLVHW-----PVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIK---PMINQVEYHP---RL 173
Cdd:cd19079 116 GTDYIDLYQIHRwdyetPIE----ETLEALHDVVKSGKVRYIGASSMYAWQFAKALHLAEKNgwtKFVSMQNHYNllyRE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 174 TQKELQAFCKEQGIQMEAWSPLMQGQL---------------------------LD---NETLQEVADKYGKTTAQIILR 223
Cdd:cd19079 192 EEREMIPLCEEEGIGVIPWSPLARGRLarpwgdtterrrsttdtaklkydyfteADkeiVDRVEEVAKERGVSMAQVALA 271
|
250 260 270
....*....|....*....|....*....|....*...
gi 487996244 224 WDLQNEVVTIP--KSTKEQRIIANANIFDFELTKEDME 259
Cdd:cd19079 272 WLLSKPGVTAPivGATKLEHLEDAVAALDIKLSEEEIK 309
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
39-261 |
1.06e-17 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 81.11 E-value: 1.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 39 AIKEGYRSIDTAAIYG---NEKAVGEGIRAGikeagisREDLFITSK---VWNADQGY-------ETTLAAYEESLKKLE 105
Cdd:cd19076 41 ALELGVTFLDTADMYGpgtNEELLGKALKDR-------RDEVVIATKfgiVRDPGSGFrgvdgrpEYVRAACEASLKRLG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 106 LDYLDLYLVH-----WPVEgkykDSWRALETLYKEERVRAIGVSN---------FQIHHLKDVlegaeikpminQVEYHP 171
Cdd:cd19076 114 TDVIDLYYQHrvdpnVPIE----ETVGAMAELVEEGKVRYIGLSEasadtirraHAVHPITAV-----------QSEYSL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 172 --RLTQKELQAFCKEQGIQMEAWSPL--------------------------MQGQLLDN-----ETLQEVADKYGKTTA 218
Cdd:cd19076 179 wtRDIEDEVLPTCRELGIGFVAYSPLgrgfltgaikspedlpeddfrrnnprFQGENFDKnlklvEKLEAIAAEKGCTPA 258
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 487996244 219 QIILRWDLQ--NEVVTIPKSTKEQRIIANANIFDFELTKEDMEKI 261
Cdd:cd19076 259 QLALAWVLAqgDDIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
43-262 |
9.88e-16 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 75.71 E-value: 9.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 43 GYRSIDTAAIYGnekAVGEGIRAGIKEAGIS--------REDLFITSKV--WNADQGY----ETTLAAYEESLKKLELDY 108
Cdd:cd19081 39 GGNFIDTADVYS---AWVPGNAGGESETIIGrwlksrgkRDRVVIATKVgfPMGPNGPglsrKHIRRAVEASLRRLQTDY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 109 LDLYLVHW-----PVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAE----IKPMINQVEY---HPRLTQK 176
Cdd:cd19081 116 IDLYQAHWddpatPLE----ETLGALNDLIRQGKVRYIGASNYSAWRLQEALELSRqhglPRYVSLQPEYnlvDRESFEG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 177 ELQAFCKEQGIQMEAWSPLMQGQL----------------------LDNE-------TLQEVADKYGKTTAQIILRWDLQ 227
Cdd:cd19081 192 ELLPLCREEGIGVIPYSPLAGGFLtgkyrseadlpgstrrgeaakrYLNErglrildALDEVAAEHGATPAQVALAWLLA 271
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 487996244 228 NEVVTIP---KSTKEQ--RIIANANIfdfELTKEDMEKID 262
Cdd:cd19081 272 RPGVTAPiagARTVEQleDLLAAAGL---RLTDEEVARLD 308
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
28-262 |
2.30e-15 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 74.58 E-value: 2.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 28 DGPELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIragikeAGIsREDLFITSK----------VWNA-DQGYETT 93
Cdd:cd19078 23 DKEEMIELIRKAVELGITFFDTAEVYGpytNEELVGEAL------KPF-RDQVVIATKfgfkidggkpGPLGlDSRPEHI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 94 LAAYEESLKKLELDYLDLYLVH-----WPVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKdvlEGAEIKPMIN-QV 167
Cdd:cd19078 96 RKAVEGSLKRLQTDYIDLYYQHrvdpnVPIE----EVAGTMKELIKEGKIRHWGLSEAGVETIR---RAHAVCPVTAvQS 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 168 EYH--PRLTQKELQAFCKEQGIQMEAWSPLMQGQL---LDNET----------------------------LQEVADKYG 214
Cdd:cd19078 169 EYSmmWREPEKEVLPTLEELGIGFVPFSPLGKGFLtgkIDENTkfdegddraslprftpealeanqalvdlLKEFAEEKG 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 487996244 215 KTTAQIILRWDLQNE--VVTIPKSTKEQRIIANANIFDFELTKEDMEKID 262
Cdd:cd19078 249 ATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENIGAADIELTPEELREIE 298
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
18-253 |
1.30e-13 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 69.12 E-value: 1.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 18 WFGlGVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGN-EKAVGEGIRagikeaGISREDLFITSKV-----WNADQGYE 91
Cdd:cd19090 9 GLG-GVFGGVDDDEAVATIRAALDLGINYIDTAPAYGDsEERLGLALA------ELPREPLVLSTKVgrlpeDTADYSAD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 92 TTLAAYEESLKKLELDYLDLYLVHWPvegkYKDSW-------RALETL--YKEE-RVRAIGVSNFQIHHLKDVLEGAEIK 161
Cdd:cd19090 82 RVRRSVEESLERLGRDRIDLLMIHDP----ERVPWvdilapgGALEALleLKEEgLIKHIGLGGGPPDLLRRAIETGDFD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 162 PMINQVEYHPrLTQKELQAF---CKEQGIQMEAWSPLMQGQLLDN--------------------ETLQEVADKYGKTTA 218
Cdd:cd19090 158 VVLTANRYTL-LDQSAADELlpaAARHGVGVINASPLGMGLLAGRppervrytyrwlspelldraKRLYELCDEHGVPLP 236
|
250 260 270
....*....|....*....|....*....|....*..
gi 487996244 219 QIILRWDLQNEVV--TIPKSTKEQRIIANANIFDFEL 253
Cdd:cd19090 237 ALALRFLLRDPRIstVLVGASSPEELEQNVAAAEGPL 273
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
36-256 |
1.02e-12 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 66.85 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 36 VKVAIKEGYRSIDTAAIYGN---EKAVGEGIRagikeaGISREDLFITSKV-WNA-DQGYETTLA------AYEESLKKL 104
Cdd:cd19074 28 VRKAYDLGINFFDTADVYAAgqaEEVLGKALK------GWPRESYVISTKVfWPTgPGPNDRGLSrkhifeSIHASLKRL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 105 ELDYLDLYLVH-----WPVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAE----IKPMINQVEYH--PRL 173
Cdd:cd19074 102 QLDYVDIYYCHrydpeTPLE----ETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLARqfglIPPVVEQPQYNmlWRE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 174 TQKELQAFCKEQGIQMEAWSPLMQG----------------------------QLLDNET------LQEVADKYGKTTAQ 219
Cdd:cd19074 178 IEEEVIPLCEKNGIGLVVWSPLAQGlltgkyrdgipppsrsratdednrdkkrRLLTDENlekvkkLKPIADELGLTLAQ 257
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 487996244 220 IILRWDLQNEVVT---IPKSTKEQrIIANANIFDFELTKE 256
Cdd:cd19074 258 LALAWCLRNPAVSsaiIGASRPEQ-LEENVKASGVKLSPE 296
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
4-261 |
1.66e-12 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 66.31 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 4 LQSKTTLHNGVEMPWFGLGV--FKVEDGPELVEA-----VKVAIKEGYRSIDTAAIYG-NEKAVGegirAGIKEAGISRE 75
Cdd:cd19144 1 IPTRTLGRNGPSVPALGFGAmgLSAFYGPPKPDEerfavLDAAFELGCTFWDTADIYGdSEELIG----RWFKQNPGKRE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 76 DLFITSKVWN----------ADQGYETTLAAYEESLKKLELDYLDLYLVH-----WPVEGKYKdswrALETLYKEERVRA 140
Cdd:cd19144 77 KIFLATKFGIeknvetgeysVDGSPEYVKKACETSLKRLGVDYIDLYYQHrvdgkTPIEKTVA----AMAELVQEGKIKH 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 141 IGVSN---------FQIHHLKDVlegaeikpminQVEYHPRLTQKE------LQAfCKEQGIQMEAWSPLMQG------- 198
Cdd:cd19144 153 IGLSEcsaetlrraHAVHPIAAV-----------QIEYSPFSLDIErpeigvLDT-CRELGVAIVAYSPLGRGfltgair 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 199 --------------------------QLLDneTLQEVADKYGKTTAQIILRWDL--QNEVVTIPKSTKEQRIIANANIFD 250
Cdd:cd19144 221 spddfeegdfrrmaprfqaenfpknlELVD--KIKAIAKKKNVTAGQLTLAWLLaqGDDIIPIPGTTKLKRLEENLGALK 298
|
330
....*....|.
gi 487996244 251 FELTKEDMEKI 261
Cdd:cd19144 299 VKLTEEEEKEI 309
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
13-246 |
2.70e-12 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 64.95 E-value: 2.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGVFKVEDGPELVEAvkvAIKEGYRSIDTAAIYGN-EKAVGEGIragikeAGISREDLFITSKVWNADQG-- 89
Cdd:cd19095 6 GTSGIGRVWGVPSEAEAARLLNT---ALDLGINLIDTAPAYGRsEERLGRAL------AGLRRDDLFIATKVGTHGEGgr 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 90 ------YETTLAAYEESLKKLELDYLDLYLVHWP-VEGKYKDSWRALETLYKEERVRAIGVSNFQiHHLKDVLEGAEIKp 162
Cdd:cd19095 77 drkdfsPAAIRASIERSLRRLGTDYIDLLQLHGPsDDELTGEVLETLEDLKAAGKVRYIGVSGDG-EELEAAIASGVFD- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 163 MInQVEYHPrLTQKELQAF--CKEQGIQMEAWSPLMQGQLLDNET----------LQEVADKYG-KTTAQIILRWDLQNE 229
Cdd:cd19095 155 VV-QLPYNV-LDREEEELLplAAEAGLGVIVNRPLANGRLRRRVRrrplyadyarRPEFAAEIGgATWAQAALRFVLSHP 232
|
250
....*....|....*....
gi 487996244 230 VVT--IPKSTKEQRIIANA 246
Cdd:cd19095 233 GVSsaIVGTTNPEHLEENL 251
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
31-264 |
2.91e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 65.43 E-value: 2.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 31 ELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIRAgikeagISREDLFITSKV--WNADQGYETTLAAYEESLKKLE 105
Cdd:cd19103 33 TLKAVFDKAMAAGLNLWDTAAVYGmgaSEKILGEFLKR------YPREDYIISTKFtpQIAGQSADPVADMLEGSLARLG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 106 LDYLDLYLVHWP--VEGKYKDswraLETLYKEERVRAIGVSNF---QIHHLKDVLEGAEIKpmINQVEYHPRLTQKE--- 177
Cdd:cd19103 107 TDYIDIYWIHNPadVERWTPE----LIPLLKSGKVKHVGVSNHnlaEIKRANEILAKAGVS--LSAVQNHYSLLYRSsee 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 178 --LQAFCKEQGIQMEAWSPLMQGQLLD----------------------------NETLQEVADKYGKTTAQIILRWDLQ 227
Cdd:cd19103 181 agILDYCKENGITFFAYMVLEQGALSGkydtkhplpegsgraetynpllpqleelTAVMAEIGAKHGASIAQVAIAWAIA 260
|
250 260 270
....*....|....*....|....*....|....*..
gi 487996244 228 NEVVTIPKSTKEQRIIANANIFDFELTKEDMEKIDAL 264
Cdd:cd19103 261 KGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
47-264 |
4.99e-12 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 64.90 E-value: 4.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 47 IDTAAIYGN---EKAVGEGIragikeAGIsREDLFITSKV------WNADQG---YETTLAAyEESLKKLELDYLDLYLV 114
Cdd:cd19087 47 FDTADVYGGgrsEEIIGRWI------AGR-RDDIVLATKVfgpmgdDPNDRGlsrRHIRRAV-EASLRRLQTDYIDLYQM 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 115 H-WPVEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAE---------IKPMINQVEYHPRLtqkELQAFCKE 184
Cdd:cd19087 119 HhFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGIAArrgllrfvsEQPMYNLLKRQAEL---EILPAARA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 185 QGIQMEAWSPL---------------MQGQLLDNET----------------LQEVADKYGKTTAQIILRWDLQNEVVTI 233
Cdd:cd19087 196 YGLGVIPYSPLagglltgkygkgkrpESGRLVERARyqarygleeyrdiaerFEALAAEAGLTPASLALAWVLSHPAVTS 275
|
250 260 270
....*....|....*....|....*....|....*..
gi 487996244 234 P---KSTKEQ---RIIAnaniFDFELTKEDMEKIDAL 264
Cdd:cd19087 276 PiigPRTLEQledSLAA----LEITLTPELLAEIDEL 308
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
13-232 |
5.49e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 64.14 E-value: 5.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGVfkVEDGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRagikeaGISREDLFITSKVWNADQG 89
Cdd:cd19105 10 GLKVSRLGFGG--GGLPRESPELLRRALDLGINYFDTAEGYGNgnsEEIIGEALK------GLRRDKVFLATKASPRLDK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 90 Y--ETTLAAYEESLKKLELDYLDLYLVH---WPVEGKYKDSW-RALETLYKEERVRAIGVS--NFQIHHLKDVLEGAE-- 159
Cdd:cd19105 82 KdkAELLKSVEESLKRLQTDYIDIYQLHgvdTPEERLLNEELlEALEKLKKEGKVRFIGFSthDNMAEVLQAAIESGWfd 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487996244 160 -IKPMINQVEYHPRLtqKELQAFCKEQGI---QMEAWSPLMQGQLLDNETLQEvadkyGKTTAQIILRWDLQNEVVT 232
Cdd:cd19105 162 vIMVAYNFLNQPAEL--EEALAAAAEKGIgvvAMKTLAGGYLQPALLSVLKAK-----GFSLPQAALKWVLSNPRVD 231
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
17-247 |
5.72e-12 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 64.04 E-value: 5.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 17 PWFGlgvfKVEDGpELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAGikeagisREDLFITSKVWNADQGY--- 90
Cdd:cd19086 16 DWWG----DVDDA-EAIRALRAALDLGINFFDTADVYGDghsERLLGKALKGR-------RDKVVIATKFGNRFDGGper 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 91 ------ETTLAAYEESLKKLELDYLDLYLVH-WPVEGKYKDSWR-ALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKP 162
Cdd:cd19086 84 pqdfspEYIREAVEASLKRLGTDYIDLYQLHnPPDEVLDNDELFeALEKLKQEGKIRAYGVSVGDPEEALAALRRGGIDV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 163 MinQVEYHP--RLTQKELQAFCKEQGIQMEAWSPLMQGqLLDnetlqevadkyGKtTAQIILRWDLQNEVVT--IPKSTK 238
Cdd:cd19086 164 V--QVIYNLldQRPEEELFPLAEEHGVGVIARVPLASG-LLT-----------GK-LAQAALRFILSHPAVStvIPGARS 228
|
....*....
gi 487996244 239 EQRIIANAN 247
Cdd:cd19086 229 PEQVEENAA 237
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
11-264 |
1.32e-11 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 64.07 E-value: 1.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 11 HNGVEMPWFGLGV--FKVEDGPELVEAVKVAIKEGYRSIDTAAIYGN-EKAVGEGIRAgikeagiSREDLFITSK--VWN 85
Cdd:COG1453 8 KTGLEVSVLGFGGmrLPRKDEEEAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKG-------PRDKVILATKlpPWV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 86 ADqgYETTLAAYEESLKKLELDYLDLYLVH-------WPVEGKYKDSWRALETLYKEERVRAIGVSNfqiHHLKDVLEGA 158
Cdd:COG1453 81 RD--PEDMRKDLEESLKRLQTDYIDLYLIHglnteedLEKVLKPGGALEALEKAKAEGKIRHIGFST---HGSLEVIKEA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 159 eikpmIN-------QVEYHPRLTQ----KELQAFCKEQGIQ---MEawsPLMQGQLLD-NETLQEVADKyGKTTAQIILR 223
Cdd:COG1453 156 -----IDtgdfdfvQLQYNYLDQDnqagEEALEAAAEKGIGviiMK---PLKGGRLANpPEKLVELLCP-PLSPAEWALR 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 487996244 224 WDLQNEVVTIPKS---TKEQrIIANANIFD-FE-LTKEDMEKIDAL 264
Cdd:COG1453 227 FLLSHPEVTTVLSgmsTPEQ-LDENLKTADnLEpLTEEELAILERL 271
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
27-224 |
1.74e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 63.49 E-value: 1.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 27 EDGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAGIKEAGISREDLFITSKVwnadqGY-------ETTLAA 96
Cdd:cd19099 18 ETDEEYREALKAALDSGINVIDTAINYRGgrsERLIGKALRELIEKGGIKRDEVVIVTKA-----GYipgdgdePLRPLK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 97 YEESLKKLELDYLDLYLVHW-------------------------------PVEG-----------KYKDSWRALETLYK 134
Cdd:cd19099 93 YLEEKLGRGLIDVADSAGLRhcispayledqierslkrlgldtidlyllhnPEEQllelgeeefydRLEEAFEALEEAVA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 135 EERVRAIGVS----------NFQIHHLKDVLEGAEIKPMIN------QVEYHPRLTQ------------KELQAFCKEQG 186
Cdd:cd19099 173 EGKIRYYGIStwdgfrappaLPGHLSLEKLVAAAEEVGGDNhhfkviQLPLNLLEPEaltekntvkgeaLSLLEAAKELG 252
|
250 260 270
....*....|....*....|....*....|....*....
gi 487996244 187 IQMEAWSPLMQGQLLDNETL-QEVADKYGKTTAQIILRW 224
Cdd:cd19099 253 LGVIASRPLNQGQLLGELRLaDLLALPGGATLAQRALQF 291
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
47-262 |
3.36e-11 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 62.62 E-value: 3.36e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 47 IDTAAIYGN---EKAVGEGIRAgikeagiSREDLFITSK-VWNADQGYETT--------LAAYEESLKKLELDYLDLYLV 114
Cdd:cd19080 48 IDTANNYTNgtsERLLGEFIAG-------NRDRIVLATKyTMNRRPGDPNAggnhrknlRRSVEASLRRLQTDYIDLLYV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 115 HW-----PVEgkykDSWRALETLYKEERVRAIGVSNF------QIHHLKDvLEGAEikPMIN-QVEYH--PRLTQKELQA 180
Cdd:cd19080 121 HAwdfttPVE----EVMRALDDLVRAGKVLYVGISDTpawvvaRANTLAE-LRGWS--PFVAlQIEYSllERTPERELLP 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 181 FCKEQGIQMEAWSPLMQGQL------------------------LDN------ETLQEVADKYGKTTAQIILRWDLQNEV 230
Cdd:cd19080 194 MARALGLGVTPWSPLGGGLLtgkyqrgeegrageakgvtvgfgkLTErnwaivDVVAAVAEELGRSAAQVALAWVRQKPG 273
|
250 260 270
....*....|....*....|....*....|....*
gi 487996244 231 VTIP---KSTKEQrIIANANIFDFELTKEDMEKID 262
Cdd:cd19080 274 VVIPiigARTLEQ-LKDNLGALDLTLSPEQLARLD 307
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
30-261 |
6.29e-11 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 61.68 E-value: 6.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 30 PELVEAVKVAIKEGYRSIDTAAIYG---NEKAVGEGIRAGIKEA-------GISREDlFITSKVwNADQGYetTLAAYEE 99
Cdd:cd19145 33 EEGIALIHHAFNSGVTFLDTSDIYGpntNEVLLGKALKDGPREKvqlatkfGIHEIG-GSGVEV-RGDPAY--VRAACEA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 100 SLKKLELDYLDLYLVHW-----PVEgkykDSWRALETLYKEERVRAIGVSN---------FQIHHLKDVlegaeikpmin 165
Cdd:cd19145 109 SLKRLDVDYIDLYYQHRidttvPIE----ITMGELKKLVEEGKIKYIGLSEasadtirraHAVHPITAV----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 166 QVEYH--PRLTQKELQAFCKEQGIQMEAWSPLMQG---------QLLDN----------------------ETLQEVADK 212
Cdd:cd19145 174 QLEWSlwTRDIEEEIIPTCRELGIGIVPYSPLGRGffagkakleELLENsdvrkshprfqgenleknkvlyERVEALAKK 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 487996244 213 YGKTTAQIILRWDLQ--NEVVTIPKSTKEQRIIANANIFDFELTKEDMEKI 261
Cdd:cd19145 254 KGCTPAQLALAWVLHqgEDVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
16-224 |
9.64e-11 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 61.03 E-value: 9.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 16 MPWFGLGVFKveDGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGegiragikEAGISREDLFITSKV--WNADQG- 89
Cdd:cd19075 8 MTFGSQGRFT--TAEAAAELLDAFLERGHTEIDTARVYPDgtsEELLG--------ELGLGERGFKIDTKAnpGVGGGLs 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 90 YETTLAAYEESLKKLELDYLDLYLVHWP-----VEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAE----I 160
Cdd:cd19075 78 PENVRKQLETSLKRLKVDKVDVFYLHAPdrstpLE----ETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKengwV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 161 KPMINQVEYHP--RLTQKELQAFCKEQGIQMEAWSPL-------------------------MQGQLLDN---------- 203
Cdd:cd19075 154 LPTVYQGMYNAitRQVETELFPCLRKLGIRFYAYSPLaggfltgkykysedkagggrfdpnnALGKLYRDrywkpsyfea 233
|
250 260
....*....|....*....|..
gi 487996244 204 -ETLQEVADKYGKTTAQIILRW 224
Cdd:cd19075 234 lEKVEEAAEKEGISLAEAALRW 255
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
22-256 |
2.75e-10 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 59.49 E-value: 2.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 22 GVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRagikeaGISREDLFITSKV------WNA--DQGY 90
Cdd:cd19163 25 GVFGPVDEEEAIRTVHEALDSGINYIDTAPWYGQgrsETVLGKALK------GIPRDSYYLATKVgrygldPDKmfDFSA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 91 ETTLAAYEESLKKLELDYLDLYLVHwPVEgkYKDSWR--------ALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKp 162
Cdd:cd19163 99 ERITKSVEESLKRLGLDYIDIIQVH-DIE--FAPSLDqilnetlpALQKLKEEGKVRFIGITGYPLDVLKEVLERSPVK- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 163 mINQVEYHPRLTQ-----KELQAFCKEQGIQMEAWSPLMQGQLLDN---------ETLQEVADK-------YGKTTAQII 221
Cdd:cd19163 175 -IDTVLSYCHYTLndtslLELLPFFKEKGVGVINASPLSMGLLTERgppdwhpasPEIKEACAKaaaycksRGVDISKLA 253
|
250 260 270
....*....|....*....|....*....|....*..
gi 487996244 222 LRWDLQNE--VVTIPKSTKEQRIIANANIFDFELTKE 256
Cdd:cd19163 254 LQFALSNPdiATTLVGTASPENLRKNLEAAEEPLDAH 290
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-229 |
1.58e-09 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 57.15 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 19 FGL--GVFKVEDGPELVEAVKV---AIKEGYRSIDTAAIYGN-EKAVGEgiragikeAGISREDLFITSKV----WNADQ 88
Cdd:cd19097 10 FGLdyGIANKSGKPSEKEAKKIleyALKAGINTLDTAPAYGDsEKVLGK--------FLKRLDKFKIITKLpplkEDKKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 89 GYETTLAAYEESLKKLELDYLDLYLVHWP--VEGKYKDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEgaEIKPMINQ 166
Cdd:cd19097 82 DEAAIEASVEASLKRLKVDSLDGLLLHNPddLLKHGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALE--SFKIDIIQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 167 VEYHP---RLTQKELQAFCKEQGIQMEAWSPLMQGQLLDN---------------ETLQEVADKYGKTTAQIILRWDLQN 228
Cdd:cd19097 160 LPFNIldqRFLKSGLLAKLKKKGIEIHARSVFLQGLLLMEpdklpakfapakpllKKLHELAKKLGLSPLELALGFVLSL 239
|
.
gi 487996244 229 E 229
Cdd:cd19097 240 P 240
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-232 |
3.06e-09 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 55.95 E-value: 3.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 19 FGLGVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGN-EKAVGEGIRAGikeagisREDLFITSKVWNADqgYETTLAAY 97
Cdd:cd19100 16 FGGGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALKGR-------RDKVFLATKTGARD--YEGAKRDL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 98 EESLKKLELDYLDLYLVH------WPVEGKYKDswRALETL--YKEE-RVRAIGVSNfqiHHLKDVLEGAEIKPM----- 163
Cdd:cd19100 87 ERSLKRLGTDYIDLYQLHavdteeDLDQVFGPG--GALEALleAKEEgKIRFIGISG---HSPEVLLRALETGEFdvvlf 161
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 164 -INQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLqevadkygktTAQIILRWDLQNEVVT 232
Cdd:cd19100 162 pINPAGDHIDSFREELLPLAREKGVGVIAMKVLAGGRLLSGDPL----------DPEQALRYALSLPPVD 221
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
34-262 |
4.33e-09 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 56.09 E-value: 4.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 34 EAVKVAIKEGYRSIDTAAIYG------NEKAVGEGIRAgikeAGISREDLFITSK--VWNADQGYETTLAAYEESLKKLE 105
Cdd:cd19077 29 ETMKAALDAGSNLWNGGEFYGppdphaNLKLLARFFRK----YPEYADKVVLSVKggLDPDTLRPDGSPEAVRKSIENIL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 106 LDYLDLYLV----------HWPVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKdvlEGAEIKPM-INQVEYHPRLT 174
Cdd:cd19077 105 RALGGTKKIdifeparvdpNVPIE----ETIKALKELVKEGKIRGIGLSEVSAETIR---RAHAVHPIaAVEVEYSLFSR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 175 QKE---LQAFCKEQGIQMEAWSPLMQG------------------QLLDN-------------ETLQEVADKYGKTTAQI 220
Cdd:cd19077 178 EIEengVLETCAELGIPIIAYSPLGRGlltgriksladipegdfrRHLDRfngenfeknlklvDALQELAEKKGCTPAQL 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 487996244 221 ILRWDL---QNEVVTIPKSTKEQRIIANANIFDFELTKEDMEKID 262
Cdd:cd19077 258 ALAWILaqsGPKIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
43-240 |
2.49e-08 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 53.87 E-value: 2.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 43 GYRSIDTAAIYG----------NEKAVGEGIragiKEAGiSREDLFITSKV---------WNAD---QGYETTLAAYEES 100
Cdd:cd19752 30 GGNFLDTANNYAfwteggvggeSERLIGRWL----KDRG-NRDDVVIATKVgagprdpdgGPESpegLSAETIEQEIDKS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 101 LKKLELDYLDLYLVH-----WPVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAE---------------- 159
Cdd:cd19752 105 LRRLGTDYIDLYYAHvddrdTPLE----ETLEAFNELVKAGKVRAIGASNFAAWRLERARQIARqqgwaefsaiqqrhsy 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 160 IKPMINQVEYHPRLTQKELQAFCKEQG-IQMEAWSPLMQGQLLDNE-----------------TLQEVADKYGKTTAQII 221
Cdd:cd19752 181 LRPRPGADFGVQRIVTDELLDYASSRPdLTLLAYSPLLSGAYTRPDrplpeqydgpdsdarlaVLEEVAGELGATPNQVV 260
|
250 260
....*....|....*....|..
gi 487996244 222 LRWDLQNEVVTIP---KSTKEQ 240
Cdd:cd19752 261 LAWLLHRTPAIIPllgASTVEQ 282
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
31-232 |
5.80e-08 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 52.56 E-value: 5.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 31 ELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAGikeagiSREDLFITSKV-WNADQGYETTLAAYEESLKKLEL 106
Cdd:cd19096 22 KAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALKEG------PREKFYLATKLpPWSVKSAEDFRRILEESLKRLGV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 107 DYLDLYLVHWPVEGKYKDS------WRALETLYKEERVRAIGVS---NFQIhhLKDVLEGAEIKpmINQVEYH----PRL 173
Cdd:cd19096 96 DYIDFYLLHGLNSPEWLEKarkgglLEFLEKAKKEGLIRHIGFSfhdSPEL--LKEILDSYDFD--FVQLQYNyldqENQ 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487996244 174 TQKELQAFCKEQG---IQMEawsPLMQGQLLDN-ETLQEVADKYGKTTAQIILRWDLQNEVVT 232
Cdd:cd19096 172 AGRPGIEYAAKKGmgvIIME---PLKGGGLANNpPEALAILCGAPLSPAEWALRFLLSHPEVT 231
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
13-247 |
1.02e-07 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 52.26 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 13 GVEMPWFGLGV---FKVEDGPE-LVEAVKVAIKEGYRSIDTAAIYGNEKAVGEgIRAGI---KEAGISREDLFITSKVwn 85
Cdd:cd19089 8 GLHLPAISLGLwhnFGDYTSPEeARELLRTAFDLGITHFDLANNYGPPPGSAE-ENFGRilkRDLRPYRDELVISTKA-- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 86 adqGYET-------------TLAAYEESLKKLELDYLDLYLVH-----WPVEgkykDSWRALETLYKEERVRAIGVSNF- 146
Cdd:cd19089 85 ---GYGMwpgpygdggsrkyLLASLDQSLKRMGLDYVDIFYHHrydpdTPLE----ETMTALADAVRSGKALYVGISNYp 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 147 --QIHHLKDVLEGAEIKPMINQVEYH--PRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDN------------------- 203
Cdd:cd19089 158 gaKARRAIALLRELGVPLIIHQPRYSllDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKylngippdsrraaeskflt 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 487996244 204 ------------ETLQEVADKYGKTTAQIILRWDLQNEVVT---IPKSTKEQrIIANAN 247
Cdd:cd19089 238 eealtpekleqlRKLNKIAAKRGQSLAQLALSWVLRDPRVTsvlIGASSPSQ-LEDNVA 295
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
38-264 |
7.04e-07 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 49.49 E-value: 7.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 38 VAIKEGYRSIDTAAIY---------G-NEKAVGEGIRAGIKeagisREDLFITSKV--------W----NADQGYETTLA 95
Cdd:cd19094 26 YAFDEGVNFIDTAEMYpvppspetqGrTEEIIGSWLKKKGN-----RDKVVLATKVagpgegitWprggGTRLDRENIRE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 96 AYEESLKKLELDYLDLYLVHWPV---------EGKYKDSWR----------ALETLYKEERVRAIGVSN------FQIHH 150
Cdd:cd19094 101 AVEGSLKRLGTDYIDLYQLHWPDrytplfgggYYTEPSEEEdsvsfeeqleALGELVKAGKIRHIGLSNetpwgvMKFLE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 151 LKDVLEGAEIKPMinQVEYHpRLTQK---ELQAFCKEQGIQMEAWSPLMQGQL----LDNET------------------ 205
Cdd:cd19094 181 LAEQLGLPRIVSI--QNPYS-LLNRNfeeGLAEACHRENVGLLAYSPLAGGVLtgkyLDGAArpeggrlnlfpgymaryr 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487996244 206 ----------LQEVADKYGKTTAQIILRWDLQNEVVT---IPKSTKEQ--RIIANaniFDFELTKEDMEKIDAL 264
Cdd:cd19094 258 spqaleavaeYVKLARKHGLSPAQLALAWVRSRPFVTstiIGATTLEQlkENIDA---FDVPLSDELLAEIDAV 328
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
31-223 |
7.13e-07 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 49.28 E-value: 7.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 31 ELVEAVKVAIKEGYRSIDTAAIYGnekaVGEG-IRAGIKEAGISREDLFITSKV------------------WnaDQGYE 91
Cdd:cd19162 20 EAAATLDAAWDAGIRYFDTAPLYG----LGLSeRRLGAALARHPRAEYVVSTKVgrllepgaagrpagadrrF--DFSAD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 92 TTLAAYEESLKKLELDYLDLYLVHWPVEGKYK---DSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPMINQVE 168
Cdd:cd19162 94 GIRRSIEASLERLGLDRLDLVFLHDPDRHLLQaltDAFPALEELRAEGVVGAIGVGVTDWAALLRAARRADVDVVMVAGR 173
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 487996244 169 YH--PRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDNETLQEVADkYGKTTAQIILR 223
Cdd:cd19162 174 YTllDRRAATELLPLCAAKGVAVVAAGVFNSGILATDDPAGDRYD-YRPATPEVLAR 229
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
43-240 |
8.88e-07 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 49.09 E-value: 8.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 43 GYRSIDTAAIYGN-------EKAVGEGIRA-GIkeagisREDLFITSK-----VWNADQGY---ETTLAAYEESLKKLEL 106
Cdd:cd19082 30 GGNFIDTARVYGDwvergasERVIGEWLKSrGN------RDKVVIATKgghpdLEDMSRSRlspEDIRADLEESLERLGT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 107 DYLDLYLVHW-----PVEgkykDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIK----PMINQVEY------HP 171
Cdd:cd19082 104 DYIDLYFLHRddpsvPVG----EIVDTLNELVRAGKIRAFGASNWSTERIAEANAYAKAHglpgFAASSPQWslarpnEP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 172 RL-------TQKELQAFCKEQGIQMEAWSPLMQG-----------------QLLDNET-------LQEVADKYGKTTAQI 220
Cdd:cd19082 180 PWpgptlvaMDEEMRAWHEENQLPVFAYSSQARGffskraaggaeddselrRVYYSEEnferlerAKELAEEKGVSPTQI 259
|
250 260
....*....|....*....|...
gi 487996244 221 ILRWDLQNEVVTIP---KSTKEQ 240
Cdd:cd19082 260 ALAYVLNQPFPTVPiigPRTPEQ 282
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
28-263 |
1.29e-05 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 45.66 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 28 DGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIragiKEAGISREDLFITSKV-WNADQGYETTLAAYEESLkk 103
Cdd:cd19143 29 DVDEAKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAI----KELGWPRSDYVVSTKIfWGGGGPPPNDRGLSRKHI-- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 104 leldyldlylvhwpVEGKYKdSWRALETLY--------------KEERVRAI------------GVSN---FQI---HHL 151
Cdd:cd19143 103 --------------VEGTKA-SLKRLQLDYvdlvfchrpdpatpIEETVRAMndlidqgkafywGTSEwsaQQIeeaHEI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 152 KDVLEgaEIKPMINQVEY---HPRLTQKELQAFCKEQGIQMEAWSPLMQGQL---------------------LDNET-- 205
Cdd:cd19143 168 ADRLG--LIPPVMEQPQYnlfHRERVEVEYAPLYEKYGLGTTTWSPLASGLLtgkynngipegsrlalpgyewLKDRKee 245
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 487996244 206 -----------LQEVADKYGKTTAQIILRWDLQNEVVT--IPKSTKEQRIIANANIFDF--ELTKEDMEKIDA 263
Cdd:cd19143 246 lgqekiekvrkLKPIAEELGCSLAQLAIAWCLKNPNVStvITGATKVEQLEENLKALEVlpKLTPEVMEKIEA 318
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
28-163 |
1.45e-05 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 45.60 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 28 DGPE---LVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAgikeAGISREDLFITSKVWN-ADQGYETTL----AA 96
Cdd:cd19153 28 DGLEqdeAVAIVAEAFAAGINHFDTSPYYGAessEAVLGKALAA----LQVPRSSYTVATKVGRyRDSEFDYSAervrAS 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 487996244 97 YEESLKKLELDYLDLYLVHwPVE-GKY----KDSWRALETLYKEERVRAIGVSNFQIHHLKDVLEGAEIKPM 163
Cdd:cd19153 104 VATSLERLHTTYLDVVYLH-DIEfVDYdtlvDEALPALRTLKDEGVIKRIGIAGYPLDTLTRATRRCSPGSL 174
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
74-259 |
2.28e-05 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 45.09 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 74 REDLFITSK----VWNA---DQGYETTL-AAYEESLKKLELDYLDLYLVHWP-VEGKYKDSWRALETLYKEERVRAIGVS 144
Cdd:cd19151 76 RDELIISTKagytMWPGpygDWGSKKYLiASLDQSLKRMGLDYVDIFYHHRPdPETPLEETMGALDQIVRQGKALYVGIS 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 145 NFQIHHLK---DVLEGAEIKPMINQVEYH--PRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDN---------------- 203
Cdd:cd19151 156 NYPPEEAReaaAILKDLGTPCLIHQPKYSmfNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTDRylngipedsraakgss 235
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 487996244 204 ---------------ETLQEVADKYGKTTAQIILRWDLQNEVVT---IPKSTKEQRIIANANIFDFELTKEDME 259
Cdd:cd19151 236 flkpeqiteeklakvRRLNEIAQARGQKLAQMALAWVLRNKRVTsvlIGASKPSQIEDAVGALDNREFSEEELA 309
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
31-264 |
6.08e-05 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 43.79 E-value: 6.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 31 ELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRAgikeagiSREDLFITSKV----WNADQGYETTLAAYEESLKK 103
Cdd:cd19104 33 EQIAAVRRALDLGINFFDTAPSYGDgksEENLGRALKG-------LPAGPYITTKVrldpDDLGDIGGQIERSVEKSLKR 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 104 LELDYLDLYLVH--------WPVEGK--------YKDSWRALETLYKEERVRAIGVSNF-QIHHLKDVLEGAeiKPMINQ 166
Cdd:cd19104 106 LKRDSVDLLQLHnrigderdKPVGGTlsttdvlgLGGVADAFERLRSEGKIRFIGITGLgNPPAIRELLDSG--KFDAVQ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 167 VEY--------------HPRLTQKELQAFCKEQGIQMEAWSPLMQGQLLDN----------------------ETLQEVA 210
Cdd:cd19104 184 VYYnllnpsaaearprgWSAQDYGGIIDAAAEHGVGVMGIRVLAAGALTTSldrgreapptsdsdvaidfrraAAFRALA 263
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 487996244 211 DKYGKTTAQIILRWDLQNEVVT--IP--KSTKEQRIIANANIFDfELTKEDMEKIDAL 264
Cdd:cd19104 264 REWGETLAQLAHRFALSNPGVStvLVgvKNREELEEAVAAEAAG-PLPAENLARLEAL 320
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
11-266 |
9.75e-05 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 43.30 E-value: 9.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 11 HNGVEMPWFGLGVFKVedGPELVEA-----VKVAIKEGYRSIDTAAIYG----------NEKAVGegirAGIKEAGiSRE 75
Cdd:PRK10625 8 HSSLEVSTLGLGTMTF--GEQNSEAdahaqLDYAVAQGINLIDVAEMYPvpprpetqglTETYIG----NWLAKRG-SRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 76 DLFITSKV----WNADQGYETTLA--------AYEESLKKLELDYLDLYLVHWPVE-----GKYKDSW----------RA 128
Cdd:PRK10625 81 KLIIASKVsgpsRNNDKGIRPNQAldrknireALHDSLKRLQTDYLDLYQVHWPQRptncfGKLGYSWtdsapavsllET 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 129 LETLYKEER---VRAIGVSN------FQIHHLKDVLEGAEIKPMINQVEYHPRLTQKELQAFCKEQGIQMEAWSPLMQGQ 199
Cdd:PRK10625 161 LDALAEQQRagkIRYIGVSNetafgvMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLAFGT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 200 L-----------------------LDNETLQ-------EVADKYGKTTAQIILRWDLQNEVV--TIPKSTKEQRIIANAN 247
Cdd:PRK10625 241 LtgkylngakpagarntlfsrftrYSGEQTQkavaayvDIAKRHGLDPAQMALAFVRRQPFVasTLLGATTMEQLKTNIE 320
|
330
....*....|....*....
gi 487996244 248 IFDFELTKEDMEKIDALNQ 266
Cdd:PRK10625 321 SLHLTLSEEVLAEIEAVHQ 339
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
20-265 |
1.74e-04 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 42.26 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 20 GLGVFKVEDGPELVEAV-KVAIKEGYRSIDTAAIYG----NEKavgegiragIKEA-GISREDLFITSKV---------W 84
Cdd:PRK10376 29 GPGVFGPPKDRDAAIAVlREAVALGVNHIDTSDFYGphvtNQL---------IREAlHPYPDDLTIVTKVgarrgedgsW 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 85 NADQGYETTLAAYEESLKKLELDY------LDLYLVHWPVEGKYKDSWRALETLYKEERVRAIGVSNFQIhhlKDVLEGA 158
Cdd:PRK10376 100 LPAFSPAELRRAVHDNLRNLGLDVldvvnlRLMGDGHGPAEGSIEEPLTVLAELQRQGLVRHIGLSNVTP---TQVAEAR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 159 EIKPmINQVEYHPRLTQKELQAFCK---EQGIQMEAWSPLMQGQLLDNETLQEVADKYGKTTAQIILRWDLQN--EVVTI 233
Cdd:PRK10376 177 KIAE-IVCVQNHYNLAHRADDALIDalaRDGIAYVPFFPLGGFTPLQSSTLSDVAASLGATPMQVALAWLLQRspNILLI 255
|
250 260 270
....*....|....*....|....*....|..
gi 487996244 234 PKSTKEQRIIANANIFDFELTKEDMEKIDALN 265
Cdd:PRK10376 256 PGTSSVAHLRENLAAAELVLSEEVLAELDGIA 287
|
|
| PBP1_sucrose_transcription_regulator |
cd06288 |
ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members ... |
34-95 |
9.66e-04 |
|
ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; This group includes the ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors. The LacI-GalR family repressors are composed of two functional domains: an N-terminal HTH (helix-turn-helix) domain, which is responsible for the DNA-binding specificity, and a C-terminal ligand-binding domain, which is homologous to the sugar-binding domain of ABC-type transport systems that contain the type 1 periplasmic binding protein-like fold. As also observed in the periplasmic binding proteins, the C-terminal domain of the bacterial transcription repressor undergoes a conformational change upon ligand binding which in turn changes the DNA binding affinity of the repressor.
Pssm-ID: 380511 [Multi-domain] Cd Length: 268 Bit Score: 39.84 E-value: 9.66e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 487996244 34 EAVKVAIKEGYRSIdtAAIYGNEKAVG-----EGIRAGIKEAGISREDLFITSKVWNADQGYETTLA 95
Cdd:cd06288 106 LATRHLIEAGHRRI--AFIGGPEDSLAtrlrlAGYRAALAEAGIPYDPSLVVHGDWGRESGYEAAKR 170
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| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
22-143 |
1.23e-03 |
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AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 39.51 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 22 GVFKVEDGPELVEAVKVAIKEGYRSIDTAAIYGN---EKAVGEGIRagikeaGISREDLFITSKV--------------- 83
Cdd:cd19152 12 NLYEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALR------ELGREDYVISTKVgrllvplqeveptfe 85
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 84 ---WNA-------DQGYETTLAAYEESLKKLELDYLDLYLVHWPVEGKYKDSW------------RALETLYKEERVRAI 141
Cdd:cd19152 86 pgfWNPlpfdavfDYSYDGILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGAESdehfaqaikgafRALEELREEGVIKAI 165
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..
gi 487996244 142 GV 143
Cdd:cd19152 166 GL 167
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| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
19-144 |
2.63e-03 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 38.80 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487996244 19 FGLGVF--KVEDGPE---LVEAVKVAIKEGYRSIDTAAIYGN-EKAVGEGIRAgiKEAGISREDLFITSKV-----WNAD 87
Cdd:cd19164 18 FGAATFsyQYTTDPEsipPVDIVRRALELGIRAFDTSPYYGPsEIILGRALKA--LRDEFPRDTYFIITKVgrygpDDFD 95
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 487996244 88 QGYETTLAAYEESLKKLELDYLDLYLVHwPVE-GKYKDSWRALETLYK---EERVRAIGVS 144
Cdd:cd19164 96 YSPEWIRASVERSLRRLHTDYLDLVYLH-DVEfVADEEVLEALKELFKlkdEGKIRNVGIS 155
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