|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
11-389 |
4.59e-174 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 490.62 E-value: 4.59e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 11 CWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIM 90
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVT 170
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 171 GAFLFLSFLIVFFFLHEE-KHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGpGTDHIE 249
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDfKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMG-DASNLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 250 MLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLK 329
Cdd:cd17391 240 FISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 330 QHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFH 389
Cdd:cd17391 320 KITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
3-388 |
3.51e-126 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 370.02 E-value: 3.51e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 3 SWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRA 82
Cdd:PRK09874 11 NWKRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 83 SLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIG 162
Cdd:PRK09874 91 ALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 163 MRHVFLVTGAFLFLSFLIVFFFLHEE-KHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLA 241
Cdd:PRK09874 171 LRPVFFITASVLFLCFLVTLFCIRENfQPVSKKEMLHMREVVTSLKNPKLVLSLFVTTLIIQVATGSIAPILTLYVRELA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 242 GpGTDHIEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLL 321
Cdd:PRK09874 251 G-NVSNIAFISGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFVQTPLQLGILRFLLGAADGALL 329
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488014886 322 PSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:PRK09874 330 PAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAVYSWN 396
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-388 |
3.25e-64 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 210.13 E-value: 3.25e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 11 CWLGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIM 90
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVA-----QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDVYQLVALRFLMGSVSGFLST-AMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLV 169
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPaAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 170 TGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWT---MVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTD 246
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSglrLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 247 HIemlaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQT 326
Cdd:cd17325 236 QI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488014886 327 LLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-352 |
5.91e-49 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 169.38 E-value: 5.91e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGAS-----PAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGM 163
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGlGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 164 RHVFLVTGAFLFLSFLIVFFFLHEekhSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGP 243
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPE---SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 244 GTDHIemlaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPS 323
Cdd:COG2814 241 SASAA----GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPL 316
|
330 340
....*....|....*....|....*....
gi 488014886 324 VQTLLKQHTPTHVTGRIFGYNQSFQFLGN 352
Cdd:COG2814 317 LQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
12-388 |
1.50e-41 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 149.65 E-value: 1.50e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 12 WLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAqwSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMT 91
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNKLGASGYY--VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 92 LMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTG 171
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 172 AFLFLSFLIVFFFLheekhsakekkaqpkkvwtmvpakHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTDHIeml 251
Cdd:cd17330 160 ALALLNLVLVLFFL------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQI--- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 252 aGAVMSATGLAVILA-APKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQ 330
Cdd:cd17330 213 -GLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSK 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488014886 331 HTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
8-386 |
1.09e-35 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 134.60 E-value: 1.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 8 LMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMA 87
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQA-----GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 88 IIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHV 166
Cdd:cd17324 76 LGNLLAALAPSFALLLLARALAGlAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 167 FLVTGAFLFLSFLIVFFFLHEEKHSAKEKKaQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTD 246
Cdd:cd17324 156 FLAIAVLALLAALLLWRLLPSLPPKKPGSL-GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 247 HIemlaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQT 326
Cdd:cd17324 235 AI----IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 327 LLKQHTPTHvTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17324 311 RVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-390 |
4.49e-34 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 130.02 E-value: 4.49e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 21 GMSLVIPFLSFYIEELGvtGTSSIAqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVY 100
Cdd:cd17489 11 SFYLLLPVLPLYAHDLG--GSEAVA---GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 101 QLVALRFLMGSVSGFLSTA-MTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFL 179
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAaATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 180 IVFFfLHEEKHSAKEKKAQPKKVWTMVPAKHLIISLFVAtFIIQLANMSIQPIITLYVKHLAGPGtdhiemlAGAVMSAT 259
Cdd:cd17489 166 LVFL-VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALIL-FLASIAYGAISTFLPLYAAERGISN-------AGLFFTVY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 260 GLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGR 339
Cdd:cd17489 237 AIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 488014886 340 IFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHS 390
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
15-388 |
2.68e-33 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 128.07 E-value: 2.68e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 15 CFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIrASLGMAIIM-TLM 93
Cdd:cd17474 8 TLLAVLGVSIVDPILPAIAEALGASPA-----QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLL-PGLLLFGIGgLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 94 GFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSeLIGMRHVFLVTGA 172
Cdd:cd17474 82 GLSDSFALLLAGRALQGiGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 173 FLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTDHIemla 252
Cdd:cd17474 161 LIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII---- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 253 GAVMSATGLAVILAAPKLGRLSDH-IGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH 331
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 488014886 332 TPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
12-384 |
2.90e-33 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 128.11 E-value: 2.90e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 12 WLGCFTTAAGMSLVIPFLSFYI-EELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIM 90
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLhQQLGLSAS-----IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDVYQLVALRFLMGSVSGFLSTAM-TLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELiGMRHVFLV 169
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASeAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 170 TGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKH-LIISLFVATFIIQLANMSIQPIITLYVKHLAGPGtdhi 248
Cdd:cd17329 159 AAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDrAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG---- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 249 EMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLL 328
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLV 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488014886 329 KQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17329 315 AALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-356 |
3.40e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 124.45 E-value: 3.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 12 WLGCFTTAAGMSLVIPFLSFYI-EELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIM 90
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEI-----GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLV 169
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGlGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 170 TGAFLFLSFLIVFFFLHEEKHSAK---EKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPgtd 246
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPkpaEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS--- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 247 hiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGII---FIPQAFVTSAWQLLILRFLLGIAQAGLLPS 323
Cdd:pfam07690 234 --ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAalgLLLLSLTLSSLWLLLALLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|...
gi 488014886 324 VQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGP 356
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-388 |
2.41e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 122.29 E-value: 2.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 8 LMICWLGCFTTAAGMSLVIPFLsfyIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMA 87
Cdd:COG2271 15 LFLAYFLNYLDRSNLSVAAPPL---QADLGLSAAQL-----GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 88 IIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHV 166
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGlGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 167 FLVTGAFLFLSFLIVFFFLheekhsakekkaqpkkvwtmvpakhliislFVATFIIQLANMSIQPIITLYVKHLAGPGTD 246
Cdd:COG2271 167 FLILGLPGLLLALLRFWLL------------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 247 HiemlAGAVMSATGLAVILAAPKLGRLSDHIGPQK--TLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSV 324
Cdd:COG2271 217 Q----AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488014886 325 QTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:COG2271 293 WALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-388 |
2.27e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 120.37 E-value: 2.27e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 2 ASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIR 81
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQL-----GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 82 ASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSEL 160
Cdd:COG2223 76 GLLLLGIGLLLLALAVSYWLLLLLGLLLGiGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 161 IGMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMV---PAKHLIISLFVATFIIQLANMSIQPIITLYV 237
Cdd:COG2223 156 FGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAlrdPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 238 KHLAgpgtdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVT-SAWQLLILRFLLGIA 316
Cdd:COG2223 236 FGLS-------AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLA 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488014886 317 QAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG-FQYVFFSTSSLLFIACIWVYF 388
Cdd:COG2223 309 LGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-388 |
4.83e-29 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 116.56 E-value: 4.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 12 WLGCFTTAAGMSLVIPFLSFYieelgVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMT 91
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWL-----VLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 92 LMGFVTD-----VYQLVALRFLMGSVSGFLSTA-MTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRH 165
Cdd:cd06173 80 VLALLALlgslsLWLLLVLAFLLGIASAFFGPArQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 166 VFLVTGAFLFLSFLIVFF----FLHEEKHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLA 241
Cdd:cd06173 160 AFAINALSFLLSALLLLFirrpPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 242 GPGtdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLL 321
Cdd:cd06173 240 GGG----AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFN 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488014886 322 PSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
8-389 |
7.67e-29 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 115.81 E-value: 7.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 8 LMICWLGCFTTAAGMSLVIPFLSFYIEELgVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMA 87
Cdd:cd17388 1 LIFILVTVLLDAMGIGLIMPVLPTLLREF-VGDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 88 IIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSElIGMRHVF 167
Cdd:cd17388 80 LDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 168 LVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKHL-----IISLFVATFIIQLANMSIQPIITLYVKHLAG 242
Cdd:cd17388 159 LVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLtgfpgLLGLLAVFFLIQLIGQVPATTWVLFTEDRFD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 243 PGTDHIemlaGAVMSATGLAVILA-APKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLIlrFLLGIAQAGL- 320
Cdd:cd17388 239 WSPTMV----GLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFP--ILILLALGGIa 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488014886 321 LPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQY---VFFSTSSLLFIACIWVYFH 389
Cdd:cd17388 313 GPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFTGIFAASPATWpglAWIIGAALYLICLVLAYRF 384
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
216-404 |
2.44e-27 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 111.59 E-value: 2.44e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 216 FVATFIIQLANMSIQPIITLYVKHLAGPGTDHIEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFI 295
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 296 PQAFVTSAWQLLILRFLLGIAqAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFST 375
Cdd:cd17391 82 LMAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFIT 160
|
170 180
....*....|....*....|....*....
gi 488014886 376 SSLLFIACIWVYFHSKNEEVSEKRHLEVS 404
Cdd:cd17391 161 GGLLFLAFLLTLFFVKEDFKPVEKKKMVS 189
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
44-390 |
2.00e-26 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 108.81 E-value: 2.00e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 44 IAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTL 122
Cdd:cd17473 33 SELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGiGVAGIMTLATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 123 IAA----ETPQEHSGWAISTISTGGVsgslLGPILGGYLSElIGMRHVFLVTgAFLFLSFLIVFFFLHEEKHSAKEKKAQ 198
Cdd:cd17473 113 IGDyfegEERAKMLGLQSAAMSLGGV----VFLLLGGALAE-IGWRAPFLVY-LLALPVLILVLLFLPEPARKSKSAASP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 199 PKKVWTMVPAKHLIIsLFVATFIIQLANMSIQPIITLYVKHLAGPGtdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIG 278
Cdd:cd17473 187 GAATAAALPWKRVLP-IYFLAFLAMLLFYVIPIQLPFLLQERGGGS----AALIGLALAIASLAGAIGALLFGRLKRRLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 279 PQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVL 358
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
|
330 340 350
....*....|....*....|....*....|...
gi 488014886 359 GGQI-AAHAGFQYVFFSTSSLLFIACIWVYFHS 390
Cdd:cd17473 342 LGPLvNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
13-364 |
2.97e-26 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 108.43 E-value: 2.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 13 LGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTL 92
Cdd:cd17504 3 LAALAVMLVETMLSPALPTIQREFGTSAA-----AVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 93 MGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGA 172
Cdd:cd17504 78 AAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 173 FLFLSFLIVffflheekhsakekkaqpkkvwTMVPAKHL----IISLFVATFIIQLANMSIQPIITLYVKHLAGPGTDHI 248
Cdd:cd17504 158 VAVLLAALV----------------------PLIDLRLLrrrnVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 249 EMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV-TSAWQLLILRFLLGIAQAGLLPSVQTL 327
Cdd:cd17504 216 ITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLhSSLWALVVALLLIGIGLGLAFASLPNI 295
|
330 340 350
....*....|....*....|....*....|....*..
gi 488014886 328 LKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAA 364
Cdd:cd17504 296 VVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-369 |
1.14e-25 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 108.07 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 13 LGCFTTAAGMSLVIPFLS-FYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHG-----RKLMLIRASLGM 86
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLyFYTDVLGLS-----AALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 87 AIIMTLMGFVTDVYQ------LVALRFLMGSVSGFLSTA-MTLIAAETPQEH-----SGWAISTISTGGVSGSLLGPILG 154
Cdd:COG2211 92 ALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPySALGAELTPDYEertrlSSWRFAFAGLGGLLASVLPPPLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 155 GYL--SELIGMRHVFLVTGAFLFLSFLIVFFFLHEeKHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPI 232
Cdd:COG2211 172 AAFggDAALGYRLTALIFAVLGLLAFLLTFFGTKE-RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 233 ITLYVKHLAGPGTDhiemLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV--TSAWQLLILR 310
Cdd:COG2211 251 LLYYFKYVLGLSAA----LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLA 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488014886 311 FLLGIAQAGLLPSVQTLL-------KQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQ 369
Cdd:COG2211 327 ALAGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYV 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-388 |
5.87e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 102.12 E-value: 5.87e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 12 WLGCFTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMT 91
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLS-----ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 92 LMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSE--LIGMRHVFL 168
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGlGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 169 VTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKHL-----IISLFVATFIIQLANMSIQPIITLYVKHLAGP 243
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVlknpgLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 244 GTDhiemLAGAVMSATGLAVILAAPKLGRLSD-HIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLP 322
Cdd:cd06174 237 SVA----VAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488014886 323 SVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd06174 313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
5-185 |
1.24e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 98.42 E-value: 1.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:cd17325 198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI----GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAM-TLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGM 163
Cdd:cd17325 274 LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
170 180
....*....|....*....|..
gi 488014886 164 RHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-366 |
1.34e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 95.32 E-value: 1.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 13 LGCFTTAAGMSLVIPFLSFYIEELGVTGTSsiAQWSGLAFGVTFlmgAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTL 92
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQ--LQWVVNAYLLAF---AALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 93 MGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTG 171
Cdd:cd17321 78 CALAPSLAFLIAARALQGiGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 172 AFLFLSFLIVFFFLheekhsakekkaqpkkvwtmvpakhliiSLFVATFIIQLANMSIQPIITLYVKHLAGpgtdHIEML 251
Cdd:cd17321 158 PIGLVALLLARTFS----------------------------GAVLAAFLLGAALGGLLFLLPLYLQGVLG----YSPLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV---TSAWQLLILRFLLGIAQAGLLPSVQTLL 328
Cdd:cd17321 206 AGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGLFATPLTNAA 285
|
330 340 350
....*....|....*....|....*....|....*...
gi 488014886 329 KQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHA 366
Cdd:cd17321 286 LSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
21-389 |
1.35e-21 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 95.37 E-value: 1.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 21 GMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTL-MGFVTDV 99
Cdd:cd17490 11 SQYVYVPFLSPYAESLGAS-----LSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLiMILFPSP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 100 YQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFL 179
Cdd:cd17490 86 WGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 180 IVFFfLHEEKHSAKEKKAQPKKVWTMVPAKHLIISLFVAtFIIQLANMSIQPIITLYVKHLAGPGTDHIEMLAGAVMSAT 259
Cdd:cd17490 166 LSLF-IKEERREKKPVLTELKELLSVLKDKKLLFFSLLA-ILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 260 GLAVILAAPKLGRLsdhIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGR 339
Cdd:cd17490 244 ALASLLSGTLFYKK---LGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRST 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 488014886 340 IFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFH 389
Cdd:cd17490 321 AMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAY 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-404 |
3.45e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 93.89 E-value: 3.45e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 208 AKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTdhiemLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVAL 287
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPA-----QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 288 FAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG 367
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190
....*....|....*....|....*....|....*..
gi 488014886 368 FQYVFFSTSSLLFIACIWVYFHSKNEEVSEKRHLEVS 404
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
13-384 |
4.52e-21 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 93.77 E-value: 4.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 13 LGCFTTAAGMSLVIPFLS-FYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHG-RKLMLIRASLGMAIIM 90
Cdd:cd17471 3 LATLLTGLAGAFVLPYLSlFLTEELGAS-----PLQIGIFMTLSALSGIVVSQWLGRLSDRGGdRKPLILLALLAGALGY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDVYQLVALRFLMGSVSgflSTAMTLI-------AAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGM 163
Cdd:cd17471 78 LLFAFLRNYWVLLLVGVVLLSLG---AAAFPQLfalareyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 164 RHVFLVTGAFLFLSFLIVFFFLhEEKHSAKEKKAQPKKVWTMVPAKHLIIsLFVATFIIQLANMSIQPIITLYV-KHLAG 242
Cdd:cd17471 155 TGLFLLAALLYLVVALLVLFLL-PSVKPPAQKATPASSLVKAPVNRRLLL-LFAAFTLLFAANSMYIIAMPLYVtNELGG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 243 PgtdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIA---QAG 319
Cdd:cd17471 233 S-----ESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFigiTAG 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488014886 320 L-LPSVQTLLKQHTPTHVTgrifGYNQSFQfLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17471 308 LgISYFQDLMPGQPGLATT----LYSNASR-IGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
16-384 |
4.64e-21 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 93.80 E-value: 4.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTL-MG 94
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLKQLGLSPT-----QIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLsLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 95 FVTDVYQLVALRFLMGSVsgFLSTAMTLIAAETPQ---EHSG-------WAistiSTGGVSGSLLGPILGGYLSELIGMR 164
Cdd:cd17335 82 FVAQIFWLLLLLVILGAF--FSAPVVPLVDSITLQylgEERErygkqrlWG----SIGFGIAALLVGILIDRSSTYKNYT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 165 HVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKKAqpKKVWTMVPAKHLIISLFVATFIiqlaNMSIQPIITLYVKHLAGPG 244
Cdd:cd17335 156 IAFYVFAVLMLLALLLALKFPFRPKHPEPNENT--GGLLALLRNPRVLAFLLVAFLM----GFGHGLIYSFLFWHLQDLG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 245 tdHIEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSV 324
Cdd:cd17335 230 --GSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488014886 325 QTLLKQHTPTHVTGRIFGYNQSFQF-LGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17335 308 VSYASAAAPPGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLL 368
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
27-185 |
1.36e-20 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 92.33 E-value: 1.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 27 PFLSFYIEELGvTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALR 106
Cdd:cd17391 222 PILTLYIRQLM-GDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILR 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 107 FLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17391 301 FLLGlATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-384 |
3.91e-20 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 90.74 E-value: 3.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 24 LVIPFLSFYIEELGVTGTSSIaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLV 103
Cdd:cd17316 16 FLIGFVAPVLAAEFSLGLSLL--QTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 104 ALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTI----STGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSF 178
Cdd:cd17316 94 VLRFLQGiGIGGEYPGASTYVAEFAPSKRRGFALGLLqsgwALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLAL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 179 LivffflheekhsakekkaqpkkvwtmvpakhLIISLFVATFIIQLANMSIQPIITLYVKHLAGpGTDHIEMLAGAVMSA 258
Cdd:cd17316 174 L-------------------------------LRRRTLLLILLWFFISFGYYGLTTFLPTYLQT-VLGLSPATSSLYLLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 259 TGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIP--QAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHV 336
Cdd:cd17316 222 ISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPlfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEV 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 488014886 337 TGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17316 302 RATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
16-384 |
4.14e-20 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 91.13 E-value: 4.14e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIEELGVtgtssIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGF 95
Cdd:cd17331 10 VLYATCYWLQQPVLPYLTKKLGV-----DSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 96 VTDVYQLVALRFLMGSVSGFLSTAMtLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLF 175
Cdd:cd17331 85 ASSVPMLFLSRLPSVFMHAMQAAQM-VVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 176 LSFLIVFFFL----HEEKHSAKEKKAQPKKVWTMVPAKHLII-----SLFVATFIIQLANMSIQPIITLYVKHLAGPGTD 246
Cdd:cd17331 164 LSIVLVILLIpsntKSKREKEAKESASPPSVFNLKEILRLLRlpgvaFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 247 HiemlAGAVMSATGLAVILA-APKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQ 325
Cdd:cd17331 244 E----NGYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVIT 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488014886 326 TLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17331 320 SLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSFGLLGAAINGLLTV 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-384 |
8.93e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 90.32 E-value: 8.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 12 WLGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMT 91
Cdd:COG2807 24 VLVALNLRPAITSVGPLLPEIRADLGLSAT-----QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 92 LMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTG 171
Cdd:COG2807 99 LRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 172 AFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWtmvPAKHLIISLFVATFIIQLANMSIqpIITLYVKHLAGPGTDhiEML 251
Cdd:COG2807 179 LLALLALLLWLPLLRRRPAAAAAAPAAASLRS---LWRSPLAWLLTLFFGLQSLLYYA--VVAWLPPILRDAGLS--AAT 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH 331
Cdd:COG2807 252 AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488014886 332 TPT-HVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG-FQYVFFSTSSLLFIACI 384
Cdd:COG2807 332 ARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLV 386
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
28-382 |
1.89e-19 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 89.44 E-value: 1.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 28 FLSFYIEELGVTGTSSIAQ-WSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMT-LMGFVT-DVYQLVA 104
Cdd:COG2270 33 VFPPYFTSVAALGDPAAATaLWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATaALFFVApGGLWLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 105 LRFLMGSVsgFLSTAMTLIAA-----ETPQEH-----SGWAI----STISTGGVSGSLLGPILGGYLSELIGMRHVFLVT 170
Cdd:COG2270 113 LLFVLANI--GFEGSLVFYNAflpdiATPEEIgrvsgLGWALgylgGVLLLLINLALFLKPEAFGLPDAGEAVRISFLLT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 171 GAFLFLSFLIVFFFLHEEKHSAKEKKAQP--------KKVWTMVPAKHLIISLFVATFIiqlANMSIQPIITL---YVKH 239
Cdd:COG2270 191 ALWWLLFALPLFLFLPERPRPGPAPPRGAvragfrelRRTLRELRRYRDLLRFLLAYFF---YRDGVQTVIAFagiYAAG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 240 LAGPGTDHIeMLAGAVMSATGlavILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAG 319
Cdd:COG2270 268 VLGFSTTEL-IVFGLLVQIVA---ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGG 343
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488014886 320 LLPSVQTLLKQHTPTHVTGRIFGYnqsFQFLGNM---IGPVLGGQIAAHAGFQYVFFSTSSLLFIA 382
Cdd:COG2270 344 IQALSRSLLARLIPPGREAEFFGL---YALSGKAasfLGPLLFGLVTQLTGSQRLGILSLIVFFVI 406
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
13-384 |
4.75e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 87.61 E-value: 4.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 13 LGCFTTAAGMSLVIPFLSFYIEELGVtgtsSIAQwSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTL 92
Cdd:cd17478 3 LGHFLNDFYQGFLPALLPLLIAKLGL----SYAQ-AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 93 MGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGA 172
Cdd:cd17478 78 LGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLII 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 173 FLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGpgtdhIEMLA 252
Cdd:cd17478 158 PGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGY-----SLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 253 GAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILrFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488014886 333 PTHV---TGRIFGYNQSfqfLGNMIGPVLGGqIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17478 312 PGNVglaSGLMMGLSFG---LGGIGAPVLGA-LADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
215-388 |
5.75e-19 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 87.65 E-value: 5.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 215 LFVATFIIQLANMSIQPIITLYVKHLAGPgtdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGS-----EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFS 374
Cdd:cd17489 76 LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155
|
170
....*....|....
gi 488014886 375 TSSLLFIACIWVYF 388
Cdd:cd17489 156 AAVLALLALLLVFL 169
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-386 |
6.48e-19 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 87.23 E-value: 6.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 13 LGCFTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTL 92
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVS-----TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 93 MGFVTDVYQLVALRFLMGSVSGFLSTAM-TLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMrhVFLVTG 171
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGAL--PFLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 172 AFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAkhliisLFVATFIIQLANMSIQPIITLYVKHLAGPGTDhieml 251
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAESISLRRLLRIAPL------ALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQ----- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFV-TSAWQLLILRFLLGIAQAGLLPSVQTLLKQ 330
Cdd:cd17477 225 AALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLYTLALALAGD 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488014886 331 HTPTHvtgRIFGYNQSFQF---LGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17477 305 RLPGD---ELVAANAALLLlygLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
25-386 |
9.82e-19 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 86.83 E-value: 9.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 25 VIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVA 104
Cdd:cd17370 18 ARSILPLFLVVLGASAA-----AVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 105 LRFLMGSVS-GFLSTAM-TLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSEL--IGMRHVFLVTGAFLFLSFLI 180
Cdd:cd17370 93 LLRILERLGkGIRTPPRdALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLlgGNYRTIFLLAAIPALLALLI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 181 VFFFLHEEKHSAKEKKAQPKKVWTMVPAKHLIIslFVATFIIQLANMSIqPIITLYVKHLAGPgtdhiEMLAGAVMSATG 260
Cdd:cd17370 173 LLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLY--LLAVALFALGNFSF-AFLILRAQELGLS-----AALIPLLYALFN 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 261 LAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRI 340
Cdd:cd17370 245 LVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTA 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 488014886 341 FGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17370 325 YGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-388 |
4.41e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 84.93 E-value: 4.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAET 127
Cdd:cd17319 41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGvAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 128 PQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLheekhsakekkaqpKKVWTMVp 207
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL--------------RQVWGLA- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 208 akhliislfVATFIIQLANMSIQPIITLYVKHLAGPGTDHIEMLAGAVMSATGLAVILAapklGRLSDHIGPQ---KTLV 284
Cdd:cd17319 186 ---------LGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILG----GRLSDRLLRGarrLVII 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 285 VALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVL-GGQIA 363
Cdd:cd17319 253 IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLiGYLVD 332
|
330 340
....*....|....*....|....*
gi 488014886 364 AHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17319 333 ATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
5-184 |
4.55e-18 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 83.71 E-value: 4.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSA-----QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGM 163
Cdd:COG0477 88 LFGLASLLCGLAPSPELLIAARALQGiGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
170 180
....*....|....*....|.
gi 488014886 164 RHVFLVTGAFLFLSFLIVFFF 184
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRL 188
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
16-396 |
1.65e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 83.36 E-value: 1.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGF 95
Cdd:COG0738 18 FLWGFATALWGPLIPALKDAFGLSDAQA-----GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 96 VTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSEL---IGMRHVFLVTGA 172
Cdd:COG0738 93 APSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 173 FLFLSFLIVFFF-LHEEKHSAKEKKAQPKKVWTMVPAKHLIIsLFVATFIIQLANMSIQPIITLYVKHLAGPGtdhiEML 251
Cdd:COG0738 173 LLLLLALLFLRSkLPEIEEEEEEAAGSAASLKSLLKNPRLLL-GGLAIFLYVGAEGAIGDWLPLYLKDVLGLS----EAT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH 331
Cdd:COG0738 248 AALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDG 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488014886 332 TPTHvTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHSKNEEVS 396
Cdd:COG0738 328 LGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
21-388 |
2.23e-17 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 82.66 E-value: 2.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 21 GMSLVIPFLSFYIEELGvtGTSSIAQWSGLAFGVTFLMGaivSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVY 100
Cdd:cd17390 11 GVSMILPLLSTHIRSLG--ASPTVIGLIGSVYGALQLFS---SPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 101 QLVALRFLMGSVSGFLSTAMTLIA-AETPQEHSGwAISTISTGGVSGSLLGPILGGYLSELI-GMRHVFLVTGAFLFLSF 178
Cdd:cd17390 86 LLFLSRIPLGIFKHTQSLCKAYLSdLVSEQERSR-VLGRFNAASSLGFILGPVVGGHLAETDgGFYYVALLCSAIFILNA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 179 LIVFFFlheekhsakekkaqPKKVWtmvpakhliiSLFVATFIIQLANMSIQPIITLYVKHLAGPGTDHIEMLAgAVMSA 258
Cdd:cd17390 165 GLVWFL--------------LSKLW----------DLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLI-SYSGV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 259 TGLAVILAAPKLGRLSDHIGpQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTG 338
Cdd:cd17390 220 LGALSGFLVGRILKLYKNNE-YLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERG 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 488014886 339 RIFGYNQSFQFLGNMIGPVLGGQIAAHAGFqYVFFSTSSLLFIACIWVYF 388
Cdd:cd17390 299 TLLGVGQSVTSLARILAPLLSGLLQEFSVS-GPGLLGAVLALAAILLMLA 347
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
21-388 |
3.07e-17 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 82.65 E-value: 3.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 21 GMSLVIPFLSFYIEELGvtgtSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVY 100
Cdd:cd17472 11 GMFLVLPVLSVYAKSLP----GATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 101 QLVALRFLMGS--VSgflSTAMTLIAAETPQEHSGWAISTISTG-GVS---GSLLGPILGGYLseliGMRHVFLVTGAFL 174
Cdd:cd17472 87 GLILGRALQGSgaIS---SVVMALLADLTREENRTKAMALIGASiGIAfaiSMVLGPLLAAHL----GVSGLFLITAILS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 175 FLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKHLIiSLFVATFIIQLANMSIQPIITLYVKHLAGPGTDHIEMLAGA 254
Cdd:cd17472 160 LVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLL-RLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 255 VMSATGLAVIL--AAPKLGRLSDHIGpqktLVVALFAAGIIFIpQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17472 239 ILIGFILMVPFviYAEKKGKMKQVFV----SSILLIAVGFLLL-LFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIA 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 488014886 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSL--LFIACIWVYF 388
Cdd:cd17472 314 PKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILalLWLLVSFLLP 371
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
211-385 |
3.33e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 82.23 E-value: 3.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 211 LIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTDhiemlAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAA 290
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQ-----LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 291 GIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQY 370
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170
....*....|....*
gi 488014886 371 VFFSTSSLLFIACIW 385
Cdd:COG2271 166 AFLILGLPGLLLALL 180
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
49-386 |
5.18e-17 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 81.90 E-value: 5.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAET 127
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGaGYGSVQPGGGRAIMRWF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 128 PQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKhSAKEKKAQPKKVWTMVP 207
Cdd:cd17475 114 PPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP-AASAATESASTLLRSLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 208 A---KHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTDHiemlAGAVMSATGLAVILAAPKLGRLSDHIGPQK--- 281
Cdd:cd17475 193 EvlrNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA----AGALLAVAQLGGALGRIGLGRVSDRVFGGRrrp 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 282 -----TLVVALFAAGIIFIPQAfvTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGP 356
Cdd:cd17475 269 vlvitAAIAAAALLVLSLLSPG--TPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGP 346
|
330 340 350
....*....|....*....|....*....|.
gi 488014886 357 VL-GGQIAAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17475 347 PLfGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
215-402 |
2.53e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.38 E-value: 2.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 215 LFVATFIIQLANMSIQPIITLYVKHLAGPGtdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGIS----PTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFS 374
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180
....*....|....*....|....*...
gi 488014886 375 TSSLLFIACIWVYFHSKNEEVSEKRHLE 402
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
16-367 |
1.88e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 77.31 E-value: 1.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIEELGVTGTssiaqWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGF 95
Cdd:cd17355 13 ILSWGIRYYFGVFIIPIIAEFGWSRA-----VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 96 VTDVYQLVALRFLMG--SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAF 173
Cdd:cd17355 88 ATSLWQLYLLWGLLGggGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 174 LFLSFLIVFFFLHEE--KHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQ-LANMSIQPIITLYVKHLAGPGTDHieM 250
Cdd:cd17355 168 ALLVLVPVLLLLRRRpaDLALRAYDDASPASPGSTLKEALRSASFWLLALAFfLCGFAVVGLIVHLVPYLADRGISP--A 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 251 LAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLIL-RFLLGIAQAGLLPSVQTLLK 329
Cdd:cd17355 246 AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLfAALFGLGWGATVPLTAALAA 325
|
330 340 350
....*....|....*....|....*....|....*...
gi 488014886 330 QHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG 367
Cdd:cd17355 326 RYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
60-355 |
2.85e-15 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 76.85 E-value: 2.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 60 AIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFL-STAMTLIAAETPQEHSGWAIST 138
Cdd:cd17503 45 AIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLiPLAQTILLRIYPPEKRGAAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 139 ISTGGVSGSLLGPILGGYLSELIGMRHVFLV-----TGAFLFLSFLIVFFFLHEEkhsakekkaqpkkvwtmvpakhLII 213
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpigILALLLAPLLDLRLFKDRN----------------------FTL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 214 SLfVATFIIQLANMSIQPIITLYVKHLAGPGTDHiemlAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGII 293
Cdd:cd17503 183 GL-LLSFLLGLGLFGAMFLLPLYLQNVLGYSAFE----SGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALG 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488014886 294 FIPQAFV---TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIG 355
Cdd:cd17503 258 TLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIG 322
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
212-388 |
1.58e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.51 E-value: 1.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 212 IISLFVATFIIQLANMSIQPIITLYVKHLAGPGTdhiemLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAG 291
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVA-----QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 292 IIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYV 371
Cdd:cd17324 76 LGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155
|
170
....*....|....*..
gi 488014886 372 FFSTSSLLFIACIWVYF 388
Cdd:cd17324 156 FLAIAVLALLAALLLWR 172
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
211-388 |
8.95e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 71.38 E-value: 8.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 211 LIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTDhiemlAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAA 290
Cdd:COG0477 15 ALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQ-----LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 291 GIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQY 370
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170
....*....|....*...
gi 488014886 371 VFFSTSSLLFIACIWVYF 388
Cdd:COG0477 170 IFLINAPLGLLALVLRLR 187
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
52-360 |
1.23e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.00 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 52 FGVTFlmGAIVSpiwGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQE 130
Cdd:TIGR00895 63 IGMAF--GALFF---GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGlGLGGLMPNLNALVSEYAPKR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 131 HSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKK--AQPKKVWTMVPA 208
Cdd:TIGR00895 138 FRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRpeTVRRIVNAIAPQ 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 209 KHLIISLFVATfiiqlaNMSIQPIITLYVKHLAGPGTDHIEML--------------------------------AGAVM 256
Cdd:TIGR00895 218 MQAEAQSALPE------QKSTQGTKRSVFKALFQGKTARITVLlwllyfmllvgvyfltnwlpklmvelgfslslAATGG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 257 SATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHV 336
Cdd:TIGR00895 292 ALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAI 371
|
330 340
....*....|....*....|....
gi 488014886 337 TGRIFGYNQSFQFLGNMIGPVLGG 360
Cdd:TIGR00895 372 RATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
8-185 |
1.46e-13 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 71.45 E-value: 1.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 8 LMICWLGCFTTAAGmSLVIPFLSFYIEELGVTGTSSIaqwsgLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMA 87
Cdd:cd17323 2 FIISFLTFVVTFGS-SIYSPALPQIAEDFHVSEEVAN-----LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 88 IIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHV 166
Cdd:cd17323 76 IFQIGCALAPNIAMLIILRFLQGfFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWI 155
|
170
....*....|....*....
gi 488014886 167 FLVTGAFLFLSFLIVFFFL 185
Cdd:cd17323 156 FWFLAIISGFCLILIFLFL 174
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-189 |
5.28e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 69.51 E-value: 5.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 7 NLMICWLGCFTTAAGMSLVIPFL-SFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGR--KLMLIRAS 83
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLpTYLVEVRGLSLAQA-----GLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGL 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 84 LGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAE-TPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIG 162
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAElFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
|
170 180
....*....|....*....|....*..
gi 488014886 163 MRHVFLVTGAFLFLSFLIVFFFLHEEK 189
Cdd:COG2271 336 YQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
16-384 |
5.03e-12 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 66.86 E-value: 5.03e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGF 95
Cdd:cd17385 9 FSSMICYSILAPFFPREAEKKGVSDTII-----GLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 96 VTDV---YQLVALRFLMGSV-----SGFLSTAMTLIAAETPqEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVF 167
Cdd:cd17385 84 LDRVpdgTVFIALCFLVRIVeavgfAAFITASFAIIAKEFP-NNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 168 LVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTmvpakhlIISLFVATFIIQLANMSI---QPIITLYVKHLAGPG 244
Cdd:cd17385 163 LVLGCLLLLTVPLNMFILPRYDDDPSPKSGSMLKLLK-------IPSVLLLCLSIVSGSVSLgflDPTLSPHLRQFKLSP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 245 TdhiemLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVV---ALFAAGIIFI-PQAFV---TSAWQLLILRFLLGIA- 316
Cdd:cd17385 236 G-----QVGLMFLILAGSYAISAPLWGWLSDKKKIPKWLMVigsIITGVGFLLLgPAPLLpikSELWMVIIGLVLLGLSl 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488014886 317 QAGLLPSVQTLL----KQHTPT--HVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:cd17385 311 GAALVPTFPELLncarEYGFPDnlSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGI 384
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
11-372 |
5.18e-12 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 66.58 E-value: 5.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 11 CWLGCFTTAAGMSLVIPFLSFYIEELGVTgtSSIAQWSGLAFGVTFLMGAIVSpiwGKLGDIHGRKLMLIRASLGMAIIM 90
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLN--VADVSVIFSSQNAGYLIGSLLA---GFLMKRLGRRRTLILGLLLISLAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYL-SELIGMRHVFLV 169
Cdd:cd17333 76 ALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 170 TGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIqLANMSIQPIITLYVKHLAGPGTDHIE 249
Cdd:cd17333 156 IGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALAL-FLYVGAETAFSSWVPSYLVEKKHVSD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 250 MLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLK 329
Cdd:cd17333 235 GLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGI 314
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 488014886 330 QHTPTHvTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVF 372
Cdd:cd17333 315 SNLPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAM 356
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
16-316 |
5.75e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 66.45 E-value: 5.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIEELGVTgtSSIAQWSglaFGVTFLMGAIVSPIWGKLGDIHGRKLMLIrASLGMAIIMTL-MG 94
Cdd:cd17320 9 ALGPLAIDMYLPALPAIARDLGAS--ASAVQLT---LSAYLLGFALGQLLYGPLSDRFGRRPVLL-AGLLLFILASLlCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 95 FVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAF 173
Cdd:cd17320 83 LASSIEQLLIARFLQGlGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 174 LFLSFLIVFFFLhEEKHSAKEKKAQPKKVW----TMVPAKHLIISLFVATFIIQ--LANMSIQPIItlYVKHLAGPGTDH 247
Cdd:cd17320 163 GLLLLLLVLLFL-PETLPEEKRKPLLSSLLraykRVLKNRRFLGYALALGLSFAglFAYLAAAPFI--YIEQLGLSPAQF 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488014886 248 iemlaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIA 316
Cdd:cd17320 240 -----GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLF 303
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
49-388 |
9.83e-12 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 65.67 E-value: 9.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTA-MTLIAAET 127
Cdd:cd17384 34 GLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAgMGMLASLY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 128 PQEHSGWAISTISTGGVS-GSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPkkVWTMV 206
Cdd:cd17384 114 PDDKERGKAMGIALGGLAlGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEGTP--WKTLL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 207 PAKHLIIslfvATFIIQLANMSI---QPIITLY-VKHLAGPgtdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKT 282
Cdd:cd17384 192 KDPYILI----AAGAICFSNSGIailEPCLPIWmMETMCPP-----KWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLC 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 283 LVVALFAAGI--IFIPqaFVTSAWQLLILRFLLGIA----QAGLLPSVQTLLKQHTpTHVTGRIFGYNQSFQFLGNMIGP 356
Cdd:cd17384 263 SLLGMLLVGIslILIP--LAKNIYGLIIPHFGLGLGigmvDSSMMPLLAYLVDLRH-SSVYGSVYAIADVAFCLAFALGP 339
|
330 340 350
....*....|....*....|....*....|..
gi 488014886 357 VLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17384 340 SLGGAIVKSIGFPWLMRIIGIINILYAPLLFF 371
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
27-382 |
1.22e-11 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 65.40 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 27 PFLSFYIEELGVTgtSSIAQWSGLAFGVTFLMGAIVSPIwgklGDIHGRKLMLIRASLGMAIIMTL-MGFVTDVYQLVAL 105
Cdd:cd06180 20 PLLPLMLAELGLS--YAQAGWIATANYAGYLVGALLASF----LRRRGRARRLIRGGLLLTVLLLAaMALTSGFAALLAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 106 RFLMGSVSGFLSTAMTLIAAE-TPQEHSGWAISTISTGGVSGSLLGPIL-GGYLSELIGMRHVFLVTGAFLFLSFLIVFF 183
Cdd:cd06180 94 RFLAGAASAFVFVFGSNLVLHhATAAGRGHLIGLLFAGVGLGIALSGLLvPAGLGGGLSWRAGWLALALLSAVLLLLSFL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 184 FLHEEKHSAKEKKAQPKKVWTMVPAKHLIIS--LFVATFIIqlanmsIQPIITLYVKHLAGPgtdhiEMLAGAVMSATGL 261
Cdd:cd06180 174 LLRRGPSAPTEASAAESAPGLNRPLWRLALAygLFGFGYII------TATFLPLIARETGAG-----SLLAGLLWSLFGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 262 AVILAAPKLGRLSDHIGPQKTLVVALFAAGI-IFIPQAFVTSAWqLLILRFLLGIAQAGLLPSVQTLLKQHTPtHVTGRI 340
Cdd:cd06180 243 AAVPSCFLWGALSDRWGTRRALAANLLVQAVgVLLPLLSPGPAG-LVLSAVLFGGTFMAITALVMALARELAP-PAAPRA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 488014886 341 FGYNQSFQFLGNMIGPVLGGQIAA-HAGFQYVFFSTSSLLFIA 382
Cdd:cd06180 321 LALMTASFGVGQILGPLLAGWLADaTGGFAPALILAAAALVVA 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
215-400 |
1.39e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 65.27 E-value: 1.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 215 LFVATFIIQLANMSIQPIITLyvkHLAGPGTDhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSL---RLEREGVS--TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGqIAAHAGFQyVFFS 374
Cdd:cd17477 76 LLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGAL-PFLI 153
|
170 180
....*....|....*....|....*.
gi 488014886 375 TSSLLFIACIWVYFHSKNEEVSEKRH 400
Cdd:cd17477 154 AAVLLLLALVPLLLTRRAAPEIEEAE 179
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
215-388 |
2.61e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 64.76 E-value: 2.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 215 LFVATFIIQLANMSIQPIITLYVKHLAGPgtdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLS-----ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAH--AGFQYVF 372
Cdd:cd06174 76 LLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVF 155
|
170
....*....|....*.
gi 488014886 373 FSTSSLLFIACIWVYF 388
Cdd:cd06174 156 LIAAALALLAAILLLL 171
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
215-388 |
3.22e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 64.17 E-value: 3.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 215 LFVATFIIQLANMSIQPIITLYVKHLAGPGTdhieMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSA----SIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 295 IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHaGFQYVFFS 374
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLA 158
|
170
....*....|....
gi 488014886 375 TSSLLFIACIWVYF 388
Cdd:cd17329 159 AAVLFLLAALVLLF 172
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
255-373 |
4.64e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 63.73 E-value: 4.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 255 VMSATGLAVILAAPKLGRLSDHIGPQKTLV--VALFAAGIIFIpqAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17321 36 VVNAYLLAFAALLLLAGRLGDRFGRKRVFLigLALFGLASLLC--ALAPSLAFLIAARALQGIGAAAIMPASLALIAATF 113
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 488014886 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:cd17321 114 PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL 154
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-184 |
9.53e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.97 E-value: 9.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 25 VIPFLSFYIEELGVTGTSSIaqwsGLAFGVTFLMGAIVSPIWGKLGD--IHGRKLMLIrASLGMAIIMTLMGFVTDVYQL 102
Cdd:cd17474 217 FLTYLPFLLELLYGISPIII----GLLFAGWSVLLALGSLFVGRLLKkrFGARRILVI-GLLLYALSLLLLGFVPSLALL 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 103 VALRFLMGSVSG-FLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIV 181
Cdd:cd17474 292 LIAIVLFGLGLGlNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
...
gi 488014886 182 FFF 184
Cdd:cd17474 372 ALL 374
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
20-372 |
1.21e-10 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 62.26 E-value: 1.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 20 AGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDV 99
Cdd:pfam12832 13 AALGCLLPYWGLYLRSIGLN-----PSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVLFLSVLFIPI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 100 YQLVALRFLMGSV-SGFLSTAMTLIAAETPQ---EHSGWAISTISTGGVSGSLLGPILgGYLSELIGMRHVFLVTGAFLF 175
Cdd:pfam12832 88 SLTFWWLALLVVLfSFFWNAILPQFEVATLQhlgEKRKDYGRQRLWGSVGFALSVFGL-GALFDHYSVGLLPSVLFYLFA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 176 LSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPGTdhiemLAGAV 255
Cdd:pfam12832 167 ALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNT-----LLGAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 256 MSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF-IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPT 334
Cdd:pfam12832 242 WALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWlLYAFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPG 321
|
330 340 350
....*....|....*....|....*....|....*....
gi 488014886 335 HVTGRIFGYNQSFQF-LGNMIGPVLGGQIAAHAGFQYVF 372
Cdd:pfam12832 322 SLQGTGQALYSGLYFgLGGALGSLIGGQLWDLFGARFTF 360
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
28-369 |
2.28e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 61.93 E-value: 2.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 28 FLSFYIEELGVTGTSSiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRF 107
Cdd:cd17371 17 LLGLVLPALIAEFGLD-EAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 108 LMGSVSGFLSTA-MTLIAAETPQEHSGWAISTISTGGVSG----SLLGPILGGYLSELIGMRHVFLVtGAFLFLSFLIVF 182
Cdd:cd17371 96 LAGLGFGGEWAAgAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL-GALPALLVLFIR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 183 FFLHE-----EKHSAKEKKAQPKKVWTMVPAKHLIISLFVATFII--QLANMSIQPIITLYVKhlagpGTDHIEML-AGA 254
Cdd:cd17371 175 RFVKEppqwqAARAARRHFADRPSLRELFSPPLLRTTLLASLLATgaLGGYYGITTWLPSYLT-----GERGLSFEgSAG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 255 VMSATGLAVILAAPKLGRLSDHIGpQKTLVVALFAAGIIFIPQAFV--TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:cd17371 250 YLVVTILGGFLGYLAGGFLADRIG-RRNNFALFALGSAISILLYFFlpLSPTLILILGFPLGFFASGPFSGMGAYLTELF 328
|
330 340 350
....*....|....*....|....*....|....*..
gi 488014886 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQ 369
Cdd:cd17371 329 PTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLG 365
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
271-388 |
3.00e-10 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 61.42 E-value: 3.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 271 GRLSDHIGPQKTLVVALFAAGII--FIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQ 348
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLAtlLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 488014886 349 FLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIAC-IWVYF 388
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWAlVWLIY 175
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
215-388 |
3.00e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.05 E-value: 3.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 215 LFVATFIIQLANMSIQPIITLYVKHLAGPGtdHIEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIF 294
Cdd:cd17330 1 LFLVVFLDALGFGIVFPVLPFYVREFNKLG--ASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 295 IPQAFVTSAWQLLILRFLLGIAqAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFS 374
Cdd:cd17330 79 VLLGLSRNLWLLFLARFLDGLT-GGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170
....*....|....
gi 488014886 375 TSSLLFIACIWVYF 388
Cdd:cd17330 158 AAALALLNLVLVLF 171
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-382 |
3.04e-10 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 61.27 E-value: 3.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSgLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGF 95
Cdd:cd17314 9 FLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIA-TAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 96 VTDVYQLV-ALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFL 174
Cdd:cd17314 88 VFNSFPLSyACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 175 F--LSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVPAKHLIIS-LFVATFIIQLANMSIQPIITLYVKHLAGPGTDHIEML 251
Cdd:cd17314 168 AivLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVFWiLFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 252 agavMSATGLAVILAAPKLGRLSD-HIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRF--LLGIAQAGLLPSVQTLL 328
Cdd:cd17314 248 ----MSIYGLFNAFGRLLWGIVADfFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTgsLLGFSYGGLFTVYPATV 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 488014886 329 KQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQI-AAHAGFQYVFFSTSSLLFIA 382
Cdd:cd17314 324 STVFGTESFATLYGILLFAPAIGSILGPMLGAKFyDRTPSYISAVYIYAVIVFLA 378
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
49-204 |
3.29e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.48 E-value: 3.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 49 GLAFGVTFlmgAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAET 127
Cdd:cd17328 40 QTVFIISY---MVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGiGEASYSPIAPTIIADLF 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488014886 128 PQEHSGWAISTISTGGVSGSLLGPILGGYLSELI-GMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWT 204
Cdd:cd17328 117 PKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTAT 194
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
5-381 |
5.36e-10 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 60.71 E-value: 5.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEG-----AFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGM 163
Cdd:PRK12307 92 AYSVGTGLSGLASGVIMLTLSRFIVGmGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGW 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 164 RHVFLVTgaflFLSFLIVFFF---------LHEEKHSAKEKKAQPKKVWTMVPAK------HLIISL--FVATFIIQLAN 226
Cdd:PRK12307 172 RAAFFVG----LLPVLLVIYIrarapeskeWEEAKLSGKGKHSQSAWSVFSLSMKglfnraQFPLTLcvFIVLFSIFGAN 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 227 MsiqPIITLYVKHLAGPGTDHIemLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQL 306
Cdd:PRK12307 248 W---PIFGLLPTYLAGEGFDTG--VVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 307 LILRFLLG-----IAQAGLLPSvqtLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG------FQYVFFST 375
Cdd:PRK12307 323 LLGACLFGlmatnVGVGGLVPK---FLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGlgaaltFIVAFWTA 399
|
....*.
gi 488014886 376 SSLLFI 381
Cdd:PRK12307 400 TILLII 405
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
57-187 |
5.76e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 57.27 E-value: 5.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 57 LMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGF-LSTAMTLIAAETPQEHSGWA 135
Cdd:TIGR00880 9 LGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFaLVAGAALIADIYPPEERGVA 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 488014886 136 ISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHE 187
Cdd:TIGR00880 89 LGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
49-373 |
6.85e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.91 E-value: 6.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAET 127
Cdd:cd17365 37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGlGLGAAMPNAITLVSEYA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 128 PQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLheekhsakekkaqpkKVWtmvp 207
Cdd:cd17365 117 PARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL---------------LLW---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 208 akhliISLFVATFIIQLANmSIQPIItlyvkhLAGPGTDHIEmlAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVAL 287
Cdd:cd17365 178 -----VTFFMGLLLVYLLN-SWLPKL------MVEAGYSLSQ--ALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 288 FAAGI-IFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQ-IAAH 365
Cdd:cd17365 244 ALGAVsLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLlLAAG 323
|
....*...
gi 488014886 366 AGFQYVFF 373
Cdd:cd17365 324 LGPESVFL 331
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-184 |
7.75e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.94 E-value: 7.75e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 8 LMICWLGCFTTAAGMSLVIPFLSFYIEelgvtGTSSIAQWSGLAFGVTFLMGAIVSpiwGKLGDIHGRKLMLIRASLGMA 87
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLG-----GGAAGYGLLLAAFGVGALLGALLL---GRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 88 IIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHV 166
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGlAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....*...
gi 488014886 167 FLVTGAFLFLSFLIVFFF 184
Cdd:cd06173 366 FLLAGALLLLAALLLLLL 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
253-392 |
8.29e-10 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 59.89 E-value: 8.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 253 GAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHT 332
Cdd:COG2223 43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 333 PTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHSKN 392
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRD 182
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
5-194 |
2.26e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.74 E-value: 2.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLS-----AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFVT-DVYQLVALRFLMGSVSGFLSTAM-TLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIG 162
Cdd:COG2223 280 LMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVfALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG 359
|
170 180 190
....*....|....*....|....*....|...
gi 488014886 163 -MRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKE 194
Cdd:COG2223 360 sYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
49-316 |
2.26e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.80 E-value: 2.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 49 GLAFGVTFLMGAIVSPIWGKLGDIHG-RKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAET 127
Cdd:cd17341 37 GLLVAIPVLAGALLRLPYGFLCDRFGgRRVFIASLLLLLIPLLALALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 128 PQEHSGWAISTISTGGVSGS----LLGPILGGYLSEL---IGMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPK 200
Cdd:cd17341 117 PKEKIGGAAGGIAGAGNMGVavsqLLAPLIAGAIVFDggfVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLK 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 201 KVWTMVPAKHL-IISLF-VATFIIQLANMSIQPiiTLYVKHLAGPGTDhiemlAGAVMSATGLAVILAAPKLGRLSDHIG 278
Cdd:cd17341 197 VQLAVLKNYRTwILSLLyGVTFGSFVGFSNVLP--TYFKTRFGLPLVT-----AGILAALFPLAGALARPAGGWLSDRFG 269
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 488014886 279 PQKTL-----VVALFAAGIIFIPQAFVTSAWQLLILRFLLGIA 316
Cdd:cd17341 270 GRRRLwwlfiVMTIGAALLSLSLPTSGTNLVLFLALFVALGLG 312
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
50-355 |
3.33e-09 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 58.31 E-value: 3.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 50 LAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQ--------LVALRFLMG-SVSGFLSTAM 120
Cdd:cd17369 48 ATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGlALGGEWGGAV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 121 TLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELI--------GMRHVFLVTGAFLFLSFLI--------VFff 184
Cdd:cd17369 128 LMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVFLLLSALLsdeaflswGWRIPFLLSAVLVAVGLYIrlrleetpVF-- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 185 lHEEKHSAKEKKAQPKKVWTMVPakhliiSLFVATFIIQLANMSIQPIITLYVKHLA--GPGTDHIEML-AGAVMSATGL 261
Cdd:cd17369 206 -RRAKEAGQVVRAPLVEVLRRHW------RALLLAIGLRLAENVLFYLFTTFALSYAtqTLGVDRSTVLlAVLIASVVAA 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 262 AVILAApklGRLSDHIGPQKTLVVALFAAGIIFIP--QAFVTSAWQLLILRFL--LGIAQAGLLPSVQTLLKQHTPTHV- 336
Cdd:cd17369 279 ITIPLF---GWLSDRVGRRPVYLAGALLAALFAFPffWLLDTGSTWLIVLAAVvvLGVLHGMMYGPQAAFLAELFPTRVr 355
|
330 340
....*....|....*....|
gi 488014886 337 -TGRIFGYNqsfqfLGNMIG 355
Cdd:cd17369 356 yTGASLGYQ-----LGAILG 370
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
16-320 |
4.63e-09 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 57.64 E-value: 4.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLsfyiEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGD-----IHGRKLMLIRASLGMAIIM 90
Cdd:cd17313 13 FGWALENSYVPPIL----QTLGLS-----HALIGFVWTLGPILGLFVQPLVGSLSDrcnsrIGRRRPFILVGAPLAALGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDV-------YQLVALRFLMG-------SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGY 156
Cdd:cd17313 84 ILIPNAADIglalgdgPRTWALVLFVLgivlldfAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 157 LSELIGM--------RHVFLVTGAFLFLSFLIVFFFLHEEKHSA-KEKKAQPKKVWTMVPAKHLIIS--------LFVAT 219
Cdd:cd17313 164 LWDHNWFgfalggnlKVPFYIGAIILLVCVLVTLFFVKEPPLSPeAGEHSENPSLGEVLKSLLKLLKimprsllrLLLVI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 220 FIIQLANMSIQPIITLYVKHLAGPGTDHIEML--AGAVMSATGLAV-----ILAAPKLGRLSDHIGPQKTLVVALFAAGI 292
Cdd:cd17313 244 FFWWIAFFPFELFFTDYMGEEVYHGTSAASSHygAGVRMGAWGLLIfslafLIFSLPIGKLGKKIGRKKVYLIGLVLFAV 323
|
330 340
....*....|....*....|....*...
gi 488014886 293 IFIPQAFVTSAWQLLILRFLLGIAQAGL 320
Cdd:cd17313 324 GMALMALVHNVTVALVLFALGGIGWATI 351
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
56-384 |
6.22e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 57.19 E-value: 6.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 56 FLMGAIVSPIWGKLGDIHGRKLMLIrASLGMAIIMTLM-GFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSG 133
Cdd:cd17502 40 LLTSTAFQPIYGKLSDLFGRKWVLL-IAIVIFELGSLLcGLAPNMTMLIVGRAIQGiGGGGLMSLAFIIIADLVPPRERG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 134 WAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVffflheekhsakekkaqpkkvwtmvpakHLII 213
Cdd:cd17502 119 KYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL----------------------------RTIL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 214 SLFVATFIIQLANMSIQPIITLYVKHLAGPGTDHiemlAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGII 293
Cdd:cd17502 171 LSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATK----SGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILMSV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 294 ----FIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGpvlggqiaahAGFQ 369
Cdd:cd17502 247 gaglLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG----------VAIT 316
|
330
....*....|....*
gi 488014886 370 YVFFSTSSLLFIACI 384
Cdd:cd17502 317 DVFLVALALAALAFL 331
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
6-182 |
7.41e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.79 E-value: 7.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 6 RNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLG 85
Cdd:cd17324 198 PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAI----IGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 86 MAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRH 165
Cdd:cd17324 274 AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAG 353
|
170
....*....|....*..
gi 488014886 166 VFLVTGAFLFLSFLIVF 182
Cdd:cd17324 354 VGWVGAALLLLALLLAL 370
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
67-388 |
7.94e-09 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 57.45 E-value: 7.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 67 GKLGDIHG-RKLMLIRASLGMAIIMTLMGFV----TDVYQLVALRFLMGSVSGFLSTAMTLIAAE-TPQEHSGWAISTIS 140
Cdd:pfam05977 66 GALADNFDrRKIMLAGQLLLALVSTLLTLLAglglLSPWLLLGLTFLGGIGTALMDPAWQASVPElVPRRDLPAAVALNS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 141 TGGVSGSLLGPILGGYLSELIGMRHVFlvtgAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKV-------WTMVPAKHLII 213
Cdd:pfam05977 146 VGYNIARSVGPALGGVLLAAFGPAFTF----ALNALSYFAVIAALWRWKRAAPASPLPRERIfgavragLRFTAMSRELR 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 214 SLFVATFIIQLANMSIQPIITLYVKHLAGPGTdhieMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGII 293
Cdd:pfam05977 222 SVLVRAFAFGLSASAVWALLPLVARDLLDGDA----IFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVVTALV 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 294 FIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:pfam05977 298 LLSLALAPNLWLAIPVLLLGGAAWITALTTLNVAVQLSVPRWVRGRALAVYQTVFFGGMAAGSWLWGAVAEALSVTGALL 377
|
330
....*....|....*
gi 488014886 374 STSSLLFIACIWVYF 388
Cdd:pfam05977 378 GAAAALLAGAAAGLR 392
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
28-388 |
1.19e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 56.41 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 28 FLSFYIEELGVtGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGdihGRKLMLIRASLgMAIIMTLMGFVTDVYQL-VALR 106
Cdd:cd17352 25 LFVELLEEFGE-STSDIAWIGSLLLGVSLFSGPLSSALVNRFG---CRPVAIAGGLL-AALGLLLSSFATSLWQLyLTYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 107 FLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFlh 186
Cdd:cd17352 100 VLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLL-- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 187 eekhsakekkaqpkKVWTMVPAKHLIISLFvatfiiqLANMSIQPIITLYVKHLAGPGTDhiEMLAGAVMSATGLAVILA 266
Cdd:cd17352 178 --------------RLLKDPTFVLLALGVS-------FAMLGFFVPFVYLPSYAKSLGID--ESDAAFLLSIIGISDIVG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 267 APKLGRLSDH--IGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYN 344
Cdd:cd17352 235 RILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLV 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 488014886 345 QSFQFLGNMIGPVLGGQIA-AHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17352 315 LLFQGLAALVGPPIAGLLRdYTGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
48-382 |
1.40e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 56.08 E-value: 1.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 48 SGLAFGVTFLMGAIVSPIWGKLGDIHG-RKLMLIrASLGMAIIMTLMGFVTdvyQLVALRFLMGSVSGFLSTAMTLIAAE 126
Cdd:cd17353 40 VALAFTLTIVFLAISAPFAGRLVDRGGpRKAILI-GGILFGLGFILSAFAI---SLPLLFLGYGVLGGIGAGIGYITPVS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 127 TPQ----EHSGwAISTISTGGVSgslLGPILGGYLSELI----GMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQ 198
Cdd:cd17353 116 TAVkwfpDKRG-LATGIVIAGFG---LGSLIFSPLIAYLintvGVPTTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVD 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 199 PKKVWTMVPAKHLIIS----------LFVATFIIQLANMSIQPIITLYVKHLAGPGTdhieMLAGAVMSATGLAVILAAP 268
Cdd:cd17353 192 PLANNAENSPRDYTPRemlrtptfwlLWLMFFLNATAGLMLIGQAKPIGQEFAGLDA----GIAALAVSILSIFNGGGRP 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 269 KLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTS-AWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSF 347
Cdd:cd17353 268 FWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSvAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTA 347
|
330 340 350
....*....|....*....|....*....|....*
gi 488014886 348 QFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIA 382
Cdd:cd17353 348 KGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVA 382
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
41-358 |
1.89e-08 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 56.23 E-value: 1.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 41 TSSIAQWSGLAFGVTflmGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLS-TA 119
Cdd:TIGR00711 35 SLSQVQWVITSYMLA---NAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIpLS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 120 MTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEK---- 195
Cdd:TIGR00711 112 FSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPAASENfdfl 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 196 ----------------KAQPKKVWT-------MVPAKHLIISLFVA--------------------------TFIIQLAN 226
Cdd:TIGR00711 192 gllllsvglgsllyglSEGPERGWFdsneiliLSITGLVAIIAFVVweltddnplvdlrlfkyrnftigcvyMSLLGLGL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 227 MSIQPIITLYVKHLAGPGTdhieMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVAL--FAAGIIFIPQAFVTSA- 303
Cdd:TIGR00711 272 YGSFYLLPLYLQQVLGYTA----LQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLilYAVGFYWRAFTFTPDTp 347
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 488014886 304 -WQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVL 358
Cdd:TIGR00711 348 fLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTAL 403
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
10-186 |
2.83e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 55.71 E-value: 2.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 10 ICWLGCFTTAAGMSLVIPFLSFYIEELGvtgTSSIAQWSGLAFGVTflmGAIVSPIWGKLGDIHGRKLMLIRASLGMAII 89
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLG---PSSNSTWISTAWSLA---QAVLGPIVGRLSDLFGRRWFFIGGNLLGVVG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 90 MTLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSE--LIGMRHVF 167
Cdd:cd06179 76 SIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIF 155
|
170
....*....|....*....
gi 488014886 168 LVTGAFLFLSFLIVFFFLH 186
Cdd:cd06179 156 YINAIFNALALILLFFFYH 174
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
65-386 |
4.40e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.59 E-value: 4.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 65 IWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGF-LSTAMTLIAAETPQEHSGWAISTISTGG 143
Cdd:cd17312 57 ISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMgWPPCVKLLGNWFSKKERGTVYGIWSTSH 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 144 VSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEkhsakekkaqPKKVWtmvpakhlIISLfvATFIIQ 223
Cdd:cd17312 137 NFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDS----------PPYVW--------VLSL--AYAFVY 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 224 LANMSIQPIITLYVKHLAGPGTdhieMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALF--------AAGIIFI 295
Cdd:cd17312 197 IVRYACLDWGPLYLYEVKGYSL----IDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIymllmtlsLALFWFF 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 296 PQAFVTSAwqllILRFLLGIAQAGLLPSVQTLLKQHTPTH-VTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGF---QYV 371
Cdd:cd17312 273 PHNKLLSI----VLLFLIGFFVGGPINLIGGAAAQDIGRKeAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWstvFYF 348
|
330
....*....|....*
gi 488014886 372 FFSTSSLLFIACIWV 386
Cdd:cd17312 349 LISAALLSVLLLLSL 363
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
9-185 |
4.73e-08 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 54.48 E-value: 4.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 9 MICWLGCFTTAA---GMSLVIPFLSfyiEELGVTGTssiaqWSGLAFGvTFLMGAIVSPIW-GKLGDIHGRKLMLIRASL 84
Cdd:cd17380 2 ILLFLATCICYAdrvNMPIAIVPMA---KEFGWSKT-----DQGLVLS-SFFWGYALTQVLgGYLADRFGGKKVLLLAVA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 --GMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAMT-LIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELI 161
Cdd:cd17380 73 lwSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTsLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY 152
|
170 180
....*....|....*....|....
gi 488014886 162 GMRHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17380 153 GWPSVFYFFGLLGLLWALVWLIYL 176
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
16-367 |
5.10e-08 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 54.53 E-value: 5.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIEELGVTGTSSiAQWsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMT-LMG 94
Cdd:cd17482 11 FATTVTTAVFPVYFKAVAAQGASPVTST-ALW-GYANSIASLVIALLAPILGAIADYSGRKKRFLAFFCLIGVVSTaLLF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 95 FVTDVYQLVALRFLMGSVSGFlSTAMTLIAAETPQEHSGWAISTISTGGVSgslLGPIlGGYLSELIGMRHVF------L 168
Cdd:cd17482 89 FVTPGQWLLALLLFILANIGF-SGANVFYDAFLPDVASPERMDRVSSLGYA---LGYI-GGGLLFAVNLVLILgpdafgL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 169 VTGAFLFLSFLIVffflheekhsakekkaqpkKVWTMV---PAKHLIISLfVATFIIqlaNMSIQPIITLYVKHlagpGT 245
Cdd:cd17482 164 DTAEAVRLSFLSV-------------------ALWWALfsiPLKQLLLFL-IAYFFY---IDGVQTIIRMATIY----GA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 246 DHIEMLAGAVMSATGLAVILAAPK---LGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLP 322
Cdd:cd17482 217 EEGKLGSSALILALLLTQFVAFPGallFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLVQGGIQA 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 488014886 323 SVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAG 367
Cdd:cd17482 297 LSRSLFGRLIPKGKSAEFFGFYNISGKFAAIIGPLLFGLITQLTG 341
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
252-372 |
6.95e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 53.90 E-value: 6.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH 331
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEY 133
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 488014886 332 TPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVF 372
Cdd:TIGR00895 134 APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLF 174
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-201 |
2.48e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.60 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 6 RNLMICWLGCFTTAAGMSLVIPFLSFYIEE-LGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASL 84
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLS-----AALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFV--TDVYQLVALRFLMG-SVSGFLSTAMTLIA-------AETPQEHSGWAISTISTGGVSGSLLGPILG 154
Cdd:COG2211 303 LAALGLLLLFFLgpGNLWLLLVLAALAGiGLGAILVLPWAMLAdvvdydeWKTGRRREGLYFGIFTFAIKLGQALAGALA 382
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488014886 155 GYLSELIG--------------MRHVFLVTGAFLFL--SFLIVFFFLHEEKHSAKEKKAQPKK 201
Cdd:COG2211 383 GLLLALFGyvagaaqspsaltgIRLLFFLLPAVLLLlaALLLLFYPLTRERHAEIRAELAARR 445
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
5-182 |
6.44e-07 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 51.01 E-value: 6.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYI-EELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRAS 83
Cdd:cd17471 198 NRRLLLLFAAFTLLFAANSMYIIAMPLYVtNELGGS-----ESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGF 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 84 LGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGM 163
Cdd:cd17471 273 LAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGY 352
|
170
....*....|....*....
gi 488014886 164 RHVFLVTGAFLFLSFLIVF 182
Cdd:cd17471 353 RAVFLVCAVLALLALVLLL 371
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
52-184 |
9.13e-07 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 50.78 E-value: 9.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 52 FGVTFLMGaivSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVS-GFLSTAMTLIAAETPQE 130
Cdd:TIGR00898 136 FFVGVLLG---SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIgGIWVQAVVLNTEFLPKK 212
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 488014886 131 HSGWaISTISTGGVSGSLLGPILGGYLseLIGMRHVFLVTGAFLFLSFLIVFFF 184
Cdd:TIGR00898 213 QRAI-VGTLIQVFFSLGLVLLPLVAYF--IPDWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
252-373 |
9.75e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 9.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 252 AGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH 331
Cdd:cd17365 36 LGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEY 115
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 488014886 332 TPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:cd17365 116 APARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL 157
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
242-388 |
9.96e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 50.27 E-value: 9.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 242 GPGTDHIEMLAGAVMSATGLAVILAapklGRLSDHIGPQKTLVV--ALFAAGIIFIpqAFVTSAWQLLILRFLLGIAQAG 319
Cdd:cd17320 30 GASASAVQLTLSAYLLGFALGQLLY----GPLSDRFGRRPVLLAglLLFILASLLC--ALASSIEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488014886 320 LLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLL 172
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
49-384 |
1.00e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 50.35 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 49 GLAFGV-TF--LMGAIVSpiwGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIA 124
Cdd:PRK11551 53 GWAFSAgILglLPGALLG---GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGvGLGGALPNLIALTS 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 125 AETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKK--- 201
Cdd:PRK11551 130 EAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRapv 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 202 VWTMVPAKHLIISL-----FVATFIIQLANMSIQPIItlyvkhLAGPGTDHIEmlAGAVMSATGLAVILAAPKLGRLSDH 276
Cdd:PRK11551 210 LRALFGEGRATATLllwisYFFTLIVLYFLLNWLPSL------LVGQGLSRSQ--AGLVQIAFNIGGALGSLLIGALMDR 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 277 IGPqkTLVVALFAAGIIF--IPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMI 354
Cdd:PRK11551 282 LRP--RRVVLLIYAGILAslAALAAAPSFAGMLLAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMA 359
|
330 340 350
....*....|....*....|....*....|.
gi 488014886 355 GPVLGGQ-IAAHAGFQYVFFSTSSLLFIACI 384
Cdd:PRK11551 360 GPLLAGQlLALGRSTVGVIGASIPVILVAAL 390
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
211-388 |
1.03e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 50.27 E-value: 1.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 211 LIISLfvATFIIQLANMSIQPIITLYVKHLagpGTDHIEMLAGAVMSATGLAV--ILAAPklgrLSDHIGPQKTLVVALF 288
Cdd:cd17323 2 FIISF--LTFVVTFGSSIYSPALPQIAEDF---HVSEEVANLGVSLFVLGFGLgpLIWAP----LSELYGRRPVYLVSLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 289 AAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGF 368
Cdd:cd17323 73 IFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152
|
170 180
....*....|....*....|
gi 488014886 369 QYVFFSTSSLLFIACIWVYF 388
Cdd:cd17323 153 RWIFWFLAIISGFCLILIFL 172
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
277-389 |
1.31e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.94 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 277 IGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQH-TPTHVTGRIfgynqSFQFLGNMIG 355
Cdd:cd17327 68 FPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWyKREEQAKRI-----AFFYAAAGLG 142
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 488014886 356 PVLGGQIAAH----------AGFQYVFFSTSSLLFIACIWVYFH 389
Cdd:cd17327 143 SIFGGLLAYGvfkilgvgglAGWRWLFIIEGLITIIIGLVIFFW 186
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
271-385 |
2.30e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 49.30 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 271 GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFG-YNQSFQF 349
Cdd:TIGR00881 51 GSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSfWNCSHNV 130
|
90 100 110
....*....|....*....|....*....|....*.
gi 488014886 350 LGNMIGPVLGGQIAAHAGFQYVFFSTSsllFIACIW 385
Cdd:TIGR00881 131 GGGLLPPLVLFGIAELYSWHWVFIVPG---IIAIIV 163
|
|
| MFS_SLC46 |
cd17386 |
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ... |
22-185 |
3.04e-06 |
|
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340944 [Multi-domain] Cd Length: 360 Bit Score: 48.81 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 22 MSLVIPFLSFYIEELGVTGTSS-----IAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLG------MAIIM 90
Cdd:cd17386 1 MLNVEPIVFLYMFASVLSGPVTqnfvyAANFYLYMNLMGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVGlllsslILVLI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDVYQLVALRF---LMGSVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVF 167
Cdd:cd17386 81 VYFTTVPSVWWFYLSAIplaLFGGFTAFLSASFAYISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSF 160
|
170
....*....|....*...
gi 488014886 168 LVTGAFLFLSFLIVFFFL 185
Cdd:cd17386 161 SISAALLLIALLYILFFL 178
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
27-187 |
3.11e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 48.72 E-value: 3.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 27 PFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSpiwGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALR 106
Cdd:cd17315 18 GALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFG---GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 107 FLMGSVSGFLSTAMTLIAAET-PQEHSGWAISTISTGGVSGSLLGPILGGYLSELI-GMRHVFLVTGAFLFLSFLIVFFF 184
Cdd:cd17315 95 FLLGLGVGLASVLVPLYISEIaPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpGWWRLMFALAAVPALLQLLLMFF 174
|
...
gi 488014886 185 LHE 187
Cdd:cd17315 175 LPE 177
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
28-369 |
3.35e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 48.76 E-value: 3.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 28 FLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIH-----GRKLMLIRASLGMAIIMTLMGFVTDVYQL 102
Cdd:cd17332 22 LLFFYTDVLGLS-----AAAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLALLFVLLFTTPDGSGT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 103 VALRFLMGSVSGF-------------LSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILG--GYLSELIGMRHVF 167
Cdd:cd17332 97 GKLIYALITYILLdllytlvnipytaLIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVAyfGGGNASRGYFLTA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 168 LVTGAFLFLSFLIVFFFLHE--EKHSAKEKKAQPKKVWTMVPAKHLIISLFVATFIIQLANMSIQPIITLYVKHLAGPGT 245
Cdd:cd17332 177 LIIGIIGIILLLICFFGTRErvVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 246 DhiemlAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVT--SAWQLLILRFLLGIAQAG---- 319
Cdd:cd17332 257 E-----LVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIGYGGanll 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 488014886 320 ---LLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQ 369
Cdd:cd17332 332 pwaMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYV 384
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
82-388 |
4.33e-06 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 49.15 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 82 ASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTA-MTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSEL 160
Cdd:PRK08633 86 FEVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAkYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFES 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 161 --------IGMRH----VFLVTGAF--LFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMVpaKHL---------IISLFV 217
Cdd:PRK08633 166 vngntpseILGRIapagLVLLAVAVlgLIFAYRLPKVPAAAPEVFDKKKYLFPKLLWRNL--KLLrsdrvlwlaIIGLSY 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 218 ATFIIQLANMSIQPiitlYVKHLAGpgtDHIEMLAGAVMSATGLAVILAAPKLGRLS-DHIgpqKTLVVALFAAGI---I 293
Cdd:PRK08633 244 FWFISQLAQANFPA----YAKEVLG---LDNTFQVQYLLAASAIGIGIGSLLAGRLSgRHI---ELGLVPLGALGLalsL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 294 FIPQAFVTSAWQLLILrFLLGIAqAGL--LPsVQTLLKQHTPTHVTGRIFGYNQSFQFLGnMIGPVLGGQIAAHAGF--Q 369
Cdd:PRK08633 314 FLLPTAPSLASVLVLF-FLFGFS-AGLfiVP-LNALIQFRAPEKELGKVLAANNFLQNVG-MLLFLALTTLFSGLGLspA 389
|
330
....*....|....*....
gi 488014886 370 YVFFSTSSLLFIACIWVYF 388
Cdd:PRK08633 390 GLFYLIALVTLIGTLYTLL 408
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
61-187 |
5.48e-06 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 48.04 E-value: 5.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 61 IVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWAISTIS 140
Cdd:cd17389 79 LSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIG 158
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 488014886 141 TGGVSGSLLGPILGGYLSELIGMRHVF------LVTGAFLFLSFLIVFFFLHE 187
Cdd:cd17389 159 VAFSLGFIIGPMIGAYFASFTRSLGEVffsmpaLFALVLALADLLFIFFFLPE 211
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
69-387 |
6.28e-06 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 47.99 E-value: 6.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 69 LGDIHGRKLMLIRASLGMAIIMTLMGFV---TDVYQLVALRFLMGSVSGFLSTAMTLIAAET-PQEHSGWAISTISTGGV 144
Cdd:cd17485 59 LPRLGRRRSWLLPTQLGLALLLLALAFLpptTNLLAFLGLLFLLNLFSATQDIATDGLAVELlTPEERGLGNAAQVVGYK 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 145 SGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVWTMV-------PAKHLIISLFV 217
Cdd:cd17485 139 LGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKASLraflrrpGTRWLLLFLLL 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 218 ATFIIQLANMSIQPIItlyvkHLAGPGTDHIEMLAGAVMSATGLAVILAApklGRLSDHIGPQKTLVVALFAAGIIFIPQ 297
Cdd:cd17485 219 YKLGEQGALAMLPPFL-----VDRGFSLSQIGLLSGVGGSLVSIAGSLLG---GYLLKRRGRRRLLLLGGLLRLLLLGLY 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 298 AFV------TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYV 371
Cdd:cd17485 291 TLLalggsgLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAA 370
|
330
....*....|....*.
gi 488014886 372 FFSTSSLLFIACIWVY 387
Cdd:cd17485 371 FLLFAILSALSVLLLL 386
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
12-384 |
6.54e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 47.76 E-value: 6.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 12 WLGCFTTAA--GMSLVIPFLSFYIEELGVTGtsSIAQWSGLAFGVTFLMGAIvspIWGKLGDIHGRKLMLIRASLGMAII 89
Cdd:TIGR00710 9 LLGCLSILGplGIDMYLPAFPEIAADLSTPA--SIVQMTLTLYLLGFAAGQL---LWGPLSDRYGRRPVLLLGLFIFALS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 90 MTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFL 168
Cdd:TIGR00710 84 SLGLALSNNIETLLVLRFVQAfGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 169 VTGAFLFLSFLIVFFFLHEEKhsAKEKKAQPKKVWT--MVPAKHLIISLFV----ATFIIQLANMSIQPIITLYVKHLAG 242
Cdd:TIGR00710 164 FLSLAGILLSALIFFILPETL--PYEARIQISTYFEtfLLLLKSKMFWGYAliygASFGGFFAFFSGAPFVYIDIMGVSP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 243 PGTDHIEMLagavmsaTGLAVILAAPKLGRLSDHIGPQKTLVVAL---FAAGIIFIPQAF--VTSAWQLLILRFLLGIAQ 317
Cdd:TIGR00710 242 SVFGLLFAL-------NIIAMIFGGFLNGRFIKKWGAKSLLRMGLilfAVSAVLLEITAIlgLGSWAMIIGPMMFVGIGN 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488014886 318 AGLLPSVQTLLKQHTPtHVTGRIFGYNQSFQF-LGNMIGPVLG---GQIAAHAGFQYVFFSTSSLLFIACI 384
Cdd:TIGR00710 315 SMISSIAMAYALEDFP-HVAGTASALFGTLRLvLGAIVGYLVSlihGNTAWPMSLSCLVLAVVSVLAFYYL 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
6-182 |
6.77e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.81 E-value: 6.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 6 RNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIaqwsGLAFGVTFLMGAIVSPIWGKLGDIH-GRKLMLIRASL 84
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA----GLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYL-SELIG 162
Cdd:cd06174 279 LMALGLALLLLAPSLLLLLLLLLLLGfGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFG 358
|
170 180
....*....|....*....|
gi 488014886 163 MRHVFLVTGAFLFLSFLIVF 182
Cdd:cd06174 359 LTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
3-182 |
7.12e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 7.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 3 SWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRA 82
Cdd:cd17478 192 GVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFA-----GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIAS 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 83 SLGMAIIMTLMGFVTDVYQLVALrFLMGSVSGFLSTAMTLIAAETPQEHSGWAIS-TISTGGVSGSLLGPILGgYLSELI 161
Cdd:cd17478 267 LLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPGNVGLASGlMMGLSFGLGGIGAPVLG-ALADAF 344
|
170 180
....*....|....*....|.
gi 488014886 162 GMRHVFLVTGAFLFLSFLIVF 182
Cdd:cd17478 345 GLESVLLILALLPLLGALLAF 365
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
57-295 |
8.63e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 47.30 E-value: 8.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 57 LMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVY-QLVALRFLMGSVSGFLSTAMTLIAAETPQEHSGWA 135
Cdd:TIGR00886 48 LAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYsVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 136 ISTISTGGVSGS----LLGPIL-------GGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEE-KHSAKEKKAQPKKVW 203
Cdd:TIGR00886 128 LGLAAGWGNMGGgvaqFVMPPIigslifgGGQPAHLAWGWAFVIVPAGILLLPALLIFFVGADTpPGKPATGKLSFKEAL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 204 TMVPAKHLII--SLFVATFIIQLAnmsIQPIITLYVKHLAGPGTDHiemlAGAVMSATGLAVILAAPKLGRLSDHIG-PQ 280
Cdd:TIGR00886 208 KVFGNRHTWIlaLLYSVTFGSFLG---VSSIFAMLFKDQFGLSKVQ----AGAYASLGGFLGSLARPAGGAISDRLGgAR 280
|
250
....*....|....*
gi 488014886 281 KTLVVALFAAGIIFI 295
Cdd:TIGR00886 281 KLLMNFLGVAMGAFL 295
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
52-344 |
1.03e-05 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 47.29 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 52 FGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGfVTDVYQ---------LVALRFLMG-SVSGFLSTAMT 121
Cdd:cd17367 46 FAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIA-VTPTYAtigiwapiiLLLARLLQGlSVGGEYGTSAT 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 122 LIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELI--------GMRHVFLVTGAFLFLSFLIVFFFlhEEKHSAK 193
Cdd:cd17367 125 YLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLgedqmaawGWRIPFLLGGVLAVVVLWLRRGL--EETESFE 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 194 EKKAQPKKVWTMVPA--KHLIISLFVatFIIQLANMSIQPIITLYVKHLAGPGTDHIEMLAGAVMSATGLAVILAAPKLG 271
Cdd:cd17367 203 AIAESNEASAGTLRElrRHPRELLLV--VGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 272 RLSDHIGpQKTLVVALFAAGIIFIPQAF-----VTSAWQLLILR---FLLGIAQAGLLPSVQTLLkqhTPTHV--TGRIF 341
Cdd:cd17367 281 RLSDRIG-RRPLLLFFGIGGTLATVPLLsaldhTDSPYTAFALVlvgLVFLSGYTSINAVVKAEL---FPTHVraLGVGL 356
|
...
gi 488014886 342 GYN 344
Cdd:cd17367 357 PYA 359
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
9-335 |
1.24e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 46.87 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 9 MICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSsiAQWSGLAFGVTFlmGAIVSpIWGKLGDIHGRKLMLIRASLGMAI 88
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQ--LSWLAASYSLTV--GTFIL-IFGRLGDIYGHKKMFVIGSFWFAI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 89 IMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIA-AETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHV 166
Cdd:cd17476 76 WSLIAGFSPNFIFFIICRALQGlGPAFLLPNAMALLGrTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 167 FLVTGAFLFLSFLIVFFFLHeekhsakekkaqpkkvwtmvpakHLIISLFVATFIIQLANMSIQPIITLYVKHLAGpgtd 246
Cdd:cd17476 156 FWFLAILAAIVAVAAIFWTS-----------------------PSFIAVLLAVFLGWASFGIWVFYATQYFQNVRG---- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 247 HIEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVAL--FAAGIIFIPQAFV-TSAW-QLLILRFLLGIAQAGLLP 322
Cdd:cd17476 209 YSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMvaFLVGPILFATMPVhQTYWaQAFPAMIVAPFGMDFSFP 288
|
330
....*....|...
gi 488014886 323 SVQTLLKQHTPTH 335
Cdd:cd17476 289 AATIIASNAVPRE 301
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
8-185 |
1.40e-05 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 46.83 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 8 LMICwLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGD-IHGRKLMLIRASLGM 86
Cdd:cd17385 204 LLLC-LSIVSGSVSLGFLDPTLSPHLRQFKLSPGQV-----GLMFLILAGSYAISAPLWGWLSDkKKIPKWLMVIGSIIT 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 87 AIIMTLMG------FVTDVYQLVALRFLMGsvsgfLSTAMTLIAAET-----------PQEHSGWA-ISTISTGGVS-GS 147
Cdd:cd17385 278 GVGFLLLGpapllpIKSELWMVIIGLVLLG-----LSLGAALVPTFPellncareygfPDNLSTYGlVSGLFNAAFSlGA 352
|
170 180 190
....*....|....*....|....*....|....*...
gi 488014886 148 LLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17385 353 FIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
271-388 |
1.65e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.50 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 271 GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQ-AGLLPSVQTLLKQHTPTHvTGRIFGYNQSFQF 349
Cdd:cd17312 59 GFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQsMGWPPCVKLLGNWFSKKE-RGTVYGIWSTSHN 137
|
90 100 110
....*....|....*....|....*....|....*....
gi 488014886 350 LGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17312 138 FGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFF 176
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
249-388 |
1.92e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.46 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 249 EMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGII--FIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQT 326
Cdd:cd17318 55 EKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLtlLTPLAARGGYGALIVLRILQGLAQGVTFPAMHA 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488014886 327 LLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACI-WVYF 388
Cdd:cd17318 135 LWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLlWFFL 197
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
255-373 |
2.64e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 255 VMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPT 334
Cdd:cd17503 36 VITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPP 115
|
90 100 110
....*....|....*....|....*....|....*....
gi 488014886 335 HVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:cd17503 116 EKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFY 154
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
13-187 |
2.71e-05 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 46.03 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 13 LGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTF--LMGAIVSpiwGKLGDIHGRKLMLIRASLGMAIIM 90
Cdd:cd17358 9 LGSFSFGIAVGWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLgaLIGALLS---GKLADRIGRKRTLLISAIPCILGW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 91 TLMGFVTDVYQLVALRFLMGSVSGFLSTAMTLIAAE-TPQEHSGWAISTISTGGVSGSLLGPILGGYLSeligmRHVFLV 169
Cdd:cd17358 86 LLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEiAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP-----WRTLAL 160
|
170
....*....|....*...
gi 488014886 170 TGAFLFLSFLIVFFFLHE 187
Cdd:cd17358 161 IGAIPPVVFLILLFFIPE 178
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
256-399 |
3.21e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 45.84 E-value: 3.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 256 MSATGLAVILAAPKL--GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTP 333
Cdd:TIGR00710 44 MTLTLYLLGFAAGQLlwGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYP 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488014886 334 THVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHSKNEEVSEKR 399
Cdd:TIGR00710 124 GEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEAR 189
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
215-388 |
3.57e-05 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 45.67 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 215 LFVATFIIQLANMSIQPIITLYVKHLAGpGTdhiEMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVV--ALFAAGi 292
Cdd:cd17472 1 LSLIFSLRMLGMFLVLPVLSVYAKSLPG-AT---PTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFglLLFIAG- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 293 iFIPQAFVTSAWQLLILRFLLGiaqAGLLPSV-QTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYV 371
Cdd:cd17472 76 -SLLAAYATSIYGLILGRALQG---SGAISSVvMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGL 151
|
170
....*....|....*..
gi 488014886 372 FFSTSSLLFIACIWVYF 388
Cdd:cd17472 152 FLITAILSLVSLLILLF 168
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
20-388 |
3.71e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.73 E-value: 3.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 20 AGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTD- 98
Cdd:pfam00083 20 GAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGk 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 99 --VYQLVALRFLMGSVSGFLSTAMTLIAAE-TPQEHSGWAISTISTGGVSGSLLGPILG---GYLSELIGMRHVFLVTGA 172
Cdd:pfam00083 100 wsVYQLIVGRVLVGIGVGGASVLAPMYISEiAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 173 FLFLSFLIVFF------FL-----HEE-------------------------KHSAKEKKAQPKKVWTMVPAKHLIISLF 216
Cdd:pfam00083 180 PALLLIIGLLFlpesprWLvekgrLEEarevlaklrgvpdvdreldeikdslEAGQEAEKASWKELFSTKTRRQRLLIGV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 217 VATFIIQLANMSIQPIITLYVKHLAGPGTDhieMLAGAVMSATGLAVILAAPklgRLSDHIGPQKTLVVALFAAGIIFIP 296
Cdd:pfam00083 260 MLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAI---FLVDRFGRRPLLLLGAAGMAICFVI 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 297 QAFVTSAWQ--------LLILRFLLGIA--QAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHA 366
Cdd:pfam00083 334 LGIVALLGVsksdwagiVAIVFIALFIAffAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAI 413
|
410 420
....*....|....*....|..
gi 488014886 367 GFQYVFFSTSSLLFIACIWVYF 388
Cdd:pfam00083 414 GLGYTFFIFAGLLVLFIIFVFF 435
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
265-367 |
4.02e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 45.30 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 265 LAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYn 344
Cdd:cd17328 49 VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGV- 127
|
90 100
....*....|....*....|....*.
gi 488014886 345 qsFQF---LGNMIGPVLGGQIAAHAG 367
Cdd:cd17328 128 --FYFaipLGSGLGYVVGGLVAQATG 151
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
56-184 |
4.28e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 45.30 E-value: 4.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 56 FLMGAIVSPI-WGKLGDIHGRKLMLIRASLGMAIIMTLMGFVT--DVYQLVALRFLMGSVSGFLSTAMTLIAAE--TPQE 130
Cdd:cd17318 65 FFYGYILTQIpGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAKwaPPLE 144
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 488014886 131 HSGwaISTISTGGVS-GSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFF 184
Cdd:cd17318 145 RSR--LTSIAYSGSQfGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL 197
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
212-387 |
5.11e-05 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 45.26 E-value: 5.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 212 IISLFVATFIIQLA-NMSIqPIITLYVKHLAGPGTdhieMLAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAA 290
Cdd:PRK05122 17 IVSIVMFTFISYLTiGLPL-AVLPGYVHDQLGFSA----FLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGC 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 291 GI--IFIPQAFVTSAWQLLIL------RFLLGIAQ-----AGLLPSVQTLLKQHtpthvTGRIFGYNQSFQFLGNMIGPV 357
Cdd:PRK05122 92 ALsgLLYLLAGLLAAWPVLSLlllllgRLLLGIGEslagtGSILWGIGRVGALH-----TGRVISWNGIATYGALAIGAP 166
|
170 180 190
....*....|....*....|....*....|
gi 488014886 358 LGGQIAAHAGFQYVFFSTSSLLFIACIWVY 387
Cdd:PRK05122 167 LGVLLYHWGGLAGLGLLIMLLALLGLLLAR 196
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-183 |
5.46e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.87 E-value: 5.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 8 LMICWLGCFTTAAGMSLVIPflSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWGKLGDIH---GRKLMLIRASL 84
Cdd:cd17319 184 LALGYFGINYALYGLLTWLP--TYLKQARGFSLKQV-----GLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFVTDVYQLVALrflMGSVSGFLSTAM----TLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSEL 160
Cdd:cd17319 257 LAAVGLLLAYLTTSPVVAVIL---LSLAGFGIGAASpvfwSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDA 333
|
170 180
....*....|....*....|....
gi 488014886 161 IG-MRHVFLVTGAFLFLSFLIVFF 183
Cdd:cd17319 334 TGsYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
27-182 |
6.31e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.84 E-value: 6.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 27 PFLSFYIEELGVTgtssiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALR 106
Cdd:cd17370 220 AFLILRAQELGLS-----AALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGF 294
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488014886 107 FLMGSVSGFLSTAM-TLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVF 182
Cdd:cd17370 295 ILWGLYMGAQESIErAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
6-194 |
1.38e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 43.60 E-value: 1.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 6 RNLMICWLGCFTTAAGMSLVIPFLSFYI-EELGvtgtssiaqWSGLAFGVTFLMGAIV----SPIWGKLGDIHGRKLMLI 80
Cdd:COG2270 238 RDLLRFLLAYFFYRDGVQTVIAFAGIYAaGVLG---------FSTTELIVFGLLVQIVaalgALLFGRLDDRIGPKRVIL 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 81 RASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFL-STAMTLIAAETPQEHSG-----WAIStistgGVSGSLLGPILG 154
Cdd:COG2270 309 VSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIqALSRSLLARLIPPGREAeffglYALS-----GKAASFLGPLLF 383
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 488014886 155 GYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKHSAKE 194
Cdd:COG2270 384 GLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVPRGRAAA 423
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
51-351 |
1.43e-04 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 43.50 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 51 AFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQ--------LVALRFLMG-SVSGFLSTAMT 121
Cdd:cd17366 45 TFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLLPTYATigvwapilLLLARMVQGfSTGGEYGGAAT 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 122 LIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGmrhvflvTGAFLFLSFLIVFFFlheekhsakekkAQPKK 201
Cdd:cd17366 125 FVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTLLLT-------EAQMLDWGWRIPFLI------------AAPLG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 202 VWTMVPAKHLIISlFVATFIIQLANMSIQPIITLYVKHLAGPGTDHIEMLAGAVMsatgLAVILAAPKLGRLSDHIGPQK 281
Cdd:cd17366 186 LVGLYLRRPLLIC-IGLVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIM----VTMLVLQPFLGRLSDRVGRKP 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488014886 282 TLVVALFAAGIIFIPqAFV----TSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIF--GYNQSFQFLG 351
Cdd:cd17366 261 VYAAGLAGLLVLAVP-AFLlmnsGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALaiAFNISVSLFG 335
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
61-203 |
1.73e-04 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 43.37 E-value: 1.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 61 IVSPIWGKLGD---IHGRK---LMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLST-----AMTLIAAETPQ 129
Cdd:cd17484 47 AIKPLYGLLSDsvpIFGYRrkpYLILAGALGALSWLALALVSNSSLALALLLLLLASLGVAFSDvvidaLVVEASRGAPQ 126
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488014886 130 EHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTgAFLFLSFLIVFFFLHEEKHSAKEKKAQPKKVW 203
Cdd:cd17484 127 SLAGDLQSLCWGSSAIGGIVGSYFSGYLLELLGPRTVFAVT-SFFPLLLLIVAFFVKEERVPPHRTKENFDEQL 199
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
251-373 |
2.03e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.94 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 251 LAGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQ 330
Cdd:cd17502 31 LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIAD 110
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 488014886 331 HTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFF 373
Cdd:cd17502 111 LVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY 153
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
43-183 |
3.13e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.61 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 43 SIAQWSGLAFGVTFLMGAIVSpiwGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSVSGFLST---A 119
Cdd:cd17313 281 RMGAWGLLIFSLAFLIFSLPI---GKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATINInpyP 357
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488014886 120 MTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFF 183
Cdd:cd17313 358 LVSDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
210-388 |
3.24e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.59 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 210 HLIISLFVATFIIQlanmsiQPIITLYVKHLAGPGTDHiemlaGAVMSATGLAVILAAPKLGRLSDHIGPQKTLVVALFA 289
Cdd:cd17331 6 HLNIVLYATCYWLQ------QPVLPYLTKKLGVDSVVF-----GYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 290 AGIIFIPQAFVTSAWqLLILRFLLGIAQAGLlPSVQTLLKQHTPTHVTGRIFGY-NQSFQfLGNMIGPVLGGQIAAHAGF 368
Cdd:cd17331 75 SALSYLLLAFASSVP-MLFLSRLPSVFMHAM-QAAQMVVTDLTDPGERAAALGRlGLSYG-IGMVVGSFLGGLLTKKFGE 151
|
170 180
....*....|....*....|
gi 488014886 369 QYVFFSTSSLLFIACIWVYF 388
Cdd:cd17331 152 QAAALVAAVGSLLSIVLVIL 171
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
271-374 |
3.39e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 42.57 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 271 GRLSDHIGPQKTLVV--ALFAAGIIFIpqAFVTSAWQLLILRFL--LGIAQAGLlpSVQTLLKQHTPTHVTGRIFGYNQS 346
Cdd:PRK11043 62 GPLSDRYGRKPVLLAglSLFALGSLGM--LWVESAAQLLVLRFVqaVGVCSAAV--IWQALVIDRYPAQKANRVFATIMP 137
|
90 100
....*....|....*....|....*...
gi 488014886 347 FQFLGNMIGPVLGGQIAAHAGFQYVFFS 374
Cdd:PRK11043 138 LVALSPALAPLLGAWLLNHFGWQAIFAT 165
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
49-187 |
6.67e-04 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 41.64 E-value: 6.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 49 GLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYqlvalrFLMGSVSGFLSTAMTLI---AA 125
Cdd:cd17387 39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRISPWWY------FAMISVSGIFSVTFSVIfayVA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488014886 126 ETPQEHS-----GWAISTISTGGVSgsllGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHE 187
Cdd:cd17387 113 DITTEEErstayGLVSATFAASLVT----SPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPE 175
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
271-388 |
6.95e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.48 E-value: 6.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 271 GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLL-KQHTPTHVTGRIFGYNQSFQF 349
Cdd:cd17476 54 GRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLgRTYPPGPRKNIVFSLFGATAP 133
|
90 100 110
....*....|....*....|....*....|....*....
gi 488014886 350 LGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYF 388
Cdd:cd17476 134 LGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIF 172
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
55-185 |
7.01e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 41.51 E-value: 7.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 55 TFLMGAIV-SPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMG-SVSGFLSTAMTLIAAETPQEHS 132
Cdd:cd17374 43 IFMAGLLVgALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGfAVSGISINTLILGTEWTTPRHR 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 488014886 133 gwAISTISTGGVSGslLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17374 123 --ALAITLTSCFFS--IGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWL 171
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
60-187 |
7.03e-04 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 41.44 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 60 AIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQLVALRFLMGSvsgFLSTAMTLIAAET----PQEHSGWA 135
Cdd:PRK11102 40 AIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL---AAAAASVVINALMrdmfPKEEFSRM 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 488014886 136 ISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHE 187
Cdd:PRK11102 117 MSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
10-199 |
7.36e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 41.59 E-value: 7.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 10 ICWLGCFTTAAGMSLVIPFLsfyIEELGVTGTSsiAQWSGLAFGVTFLMGAIVSpiwGKLGDIHGRKLMLIRASLGMAII 89
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYL---VEEIGLSKTD--LGLLLSSFSIAYGISKFVM---GSVSDRSNPRVFLPIGLILCAIV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 90 MTLMGFVTDVYQLVALRFLMGSVSGF-LSTAMTLIAAETPQEHSGWAISTISTG-GVSGSLLGPILGGYLSELIGMRHVF 167
Cdd:TIGR00881 74 NLFFGFSTSLWVMAALWALNGIFQGMgWPPCGRTVTKWFSRSERGTWVSFWNCShNVGGGLLPPLVLFGIAELYSWHWVF 153
|
170 180 190
....*....|....*....|....*....|..
gi 488014886 168 LVTGAFLFLSFLIVFFFLHEEKHSAKEKKAQP 199
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQSCGLPPAEE 185
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
271-381 |
1.35e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 40.84 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 271 GRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSA-----WQLLILRFLLGIAQAGLLPSvqtLLKQHTPTHVTGRIFGYNQ 345
Cdd:PRK03893 332 GFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGAnvwvlGLLLFFQQMLGQGISGLLPK---LIGGYFDTEQRAAGLGFTY 408
|
90 100 110
....*....|....*....|....*....|....*..
gi 488014886 346 SFQFLGNMIGPVLGGQIAAHAGFQYVFFSTS-SLLFI 381
Cdd:PRK03893 409 NVGALGGALAPILGALIAQRLDLGTALASLSfSLTFV 445
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
47-187 |
1.98e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.98 E-value: 1.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 47 WSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGFVTDVY-QLVALRFLMG-SVSGFLSTAMTLIA 124
Cdd:cd17371 246 GSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPtLILILGFPLGfFASGPFSGMGAYLT 325
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488014886 125 AETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHE 187
Cdd:cd17371 326 ELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPE 388
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-185 |
2.24e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.85 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 16 FTTAAGMSLVIPFLSFYIeeLGVTGTSsiAQWSGLAFGVTFLMGAIVSPIWGKLGDIHGRKLMLIRASLGMAIIMTLMGF 95
Cdd:cd17321 178 FLLGAALGGLLFLLPLYL--QGVLGYS--PLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 96 V---TDVYQLVALRFLMGSVSGFLSTAMTLIAAET-PQEHSGWAISTIST-----GGVSGSLLGPILGGYLSELI----- 161
Cdd:cd17321 254 LgadSSVWLLLPGLVLLGLGLGLFATPLTNAALSSvPKEKAGAASGILNTarqlgGALGVALLGALLTAGLSANLgdsgv 333
|
170 180 190
....*....|....*....|....*....|....*..
gi 488014886 162 -------------GMRHVFLVTGAFLFLSFLIVFFFL 185
Cdd:cd17321 334 aallsaaaaafaaGFHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
13-185 |
2.37e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 13 LGCFTTAAGMSLVIPFLSFYIEELGVTGTSSiaqwsGLAFGVTFLMGAIVSPIWG-KLGDIHGRKLMLIRASLGMAIIMT 91
Cdd:cd17490 202 LAILQQMITFSTTFGFTPLIAKQLGASSFQL-----GLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYCF 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 92 LMGFVTDVYQLVALRFLMGSVSGFLSTA-MTLIAAETPQEHSGWAISTISTGGVSGSLLGPILGGYLSELIGMRHVFLVT 170
Cdd:cd17490 277 LIPFAPNLTLLYLLQALNGFGTGILFPLlMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVI 356
|
170
....*....|....*
gi 488014886 171 GAFLFLSFLIVFFFL 185
Cdd:cd17490 357 GVIALLAAILSLAYY 371
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
146-386 |
4.74e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 38.71 E-value: 4.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 146 GSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFlheekhsaKEKKAQPKKVWTMvpakhLIISLFVATFIIQLA 225
Cdd:cd17346 145 GAFLAPLLCGTLGDNYGYHYGFGLAAVGMLLGLLIFLLG--------RKKLLERKKMLAI-----IILFLFAVVFWAIYE 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 226 NMSIqpIITLYVKHLAGPGTDHIEMLAGAVMSATGLAVILAAP-------KLGRLSDHIG-PQKT----LVVAL----FA 289
Cdd:cd17346 212 QAGT--SLALFADENVDRLLGGFTIPPSWFQSLNPLFIILLAPilaalwtKLGKRGKDPSiPTKFalglLLLGLsfllMV 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 290 AGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQ 369
Cdd:cd17346 290 LAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFYAQPKDPL 369
|
250
....*....|....*..
gi 488014886 370 YVFFSTSSLLFIACIWV 386
Cdd:cd17346 370 ASALVYTDYFGLIGVIA 386
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
261-386 |
5.04e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 5.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 261 LAVILAAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRI 340
Cdd:cd17317 36 LGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFV 115
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 488014886 341 FGYNQSFQFLGNMIGPVLGGQIaAHAGFQYVFFSTSSLLFIACIWV 386
Cdd:cd17317 116 GILFGLFWALGYMLLALLAYLI-RDWRWLQLAISLPGLLFLLLLWW 160
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
5-190 |
5.55e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.79 E-value: 5.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 5 KRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTssiAQWSGLAFGVTFLMgaivSPIWGKLGDIHGRKLMLIRASL 84
Cdd:pfam00083 253 QRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVF----TFIAIFLVDRFGRRPLLLLGAA 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 85 GMAIIMTLMGFVTDVYQ-------LVALRFLMGSVSGFLSTA---MTLIAAET-PQEHSGWAISTISTGGVSGSLLGPIL 153
Cdd:pfam00083 326 GMAICFVILGIVALLGVsksdwagIVAIVFIALFIAFFAMGWgpvPWVIVSELfPLSVRSKAMALATAANWLANFLIGFL 405
|
170 180 190
....*....|....*....|....*....|....*..
gi 488014886 154 GGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKH 190
Cdd:pfam00083 406 FPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKG 442
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
69-184 |
5.93e-03 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 38.41 E-value: 5.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 69 LGDIHGRKLMLIRASLGMAIIMTLMGFVTDVYQL-VALRFLMGSVSGFLST----AMTLIAaetPQEHSGWAISTISTG- 142
Cdd:cd17364 263 LIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKIsTIGFFVLYGLTFFFSNfgpnTTTFIV---PAEVFPARVRSTCHGi 339
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 488014886 143 ----GVSGSLLGPILGGYLSELIGMRHVFLVTGAFLFLSFLIVFFF 184
Cdd:cd17364 340 saasGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLF 385
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
6-190 |
6.88e-03 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 38.47 E-value: 6.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 6 RNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQwSGLAFGVTFLMGAIVSPIWGKLGdihgRKLMLIRASLG 85
Cdd:TIGR00879 284 RLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLV-SIIVGAVNFAFTFVAIFLVDRFG----RRPLLLIGAAG 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 86 MAIIMTLMGFVTdVYQLVALRFLMGSVSGFL------STAMT------LIAAET-PQEHSGWAISTISTGGVSGSLLGPI 152
Cdd:TIGR00879 359 MAICLFVLGILG-ASFVTGSSKSSGNVAIVFillfiaFFAMGwgpvpwVIVSEIfPLSLRPKGISIAVAANWLANFIVGF 437
|
170 180 190
....*....|....*....|....*....|....*...
gi 488014886 153 LGGYLSELIGMRHVFLVTGAFLFLSFLIVFFFLHEEKH 190
Cdd:TIGR00879 438 LFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETKG 475
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
51-342 |
7.45e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.12 E-value: 7.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 51 AFGVTFLMGAIVSPIWGKLGDIHGRKLMLIrASLGMAIIMTLMGFVTDVYQ---------LVALRFLMG-SVSGFLSTAM 120
Cdd:cd17368 45 TFGVGFFMRPIGAIVLGAYADRIGRKPAMT-LTLAIMALGTLLIALAPTYAtigiaapllVLLARLLQGfAAGGEVGGVT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 121 TLIAAETPQEHSG----WAISTISTGGVSGSLLGPILGGYLSELI----GMRHVFLV------TGAFLFLSFLIVFFFLH 186
Cdd:cd17368 124 AYLVEAAPPGRRGfytsWQSASQQVAIVAGALVGYLLSLTLTAEAlaewGWRIPFFIglliipLGLWLRRSLEETEAFLE 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 187 EEKHSAKEKK-AQPKKVWTMVPAKHLIISLFVATFIIQLANMsiqPIITLYVKHLAGPGTDHIEMLAGAVMsatglavIL 265
Cdd:cd17368 204 RKARPTRRELfALLANNRRIILLGMLLVAGSTVTFYFTTVYT---PTYAKTVLGLSARDSFLVTLLAGVAN-------FI 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488014886 266 AAPKLGRLSDHIGPQKTLVVALFAAGIIFIPQ-AFVT---SAWQLLILRFLLGIAQAGLLPSVQTLLKQHTPTHVTGRIF 341
Cdd:cd17368 274 WAPLGGALSDRIGRRPVLLVITLAALVTLYPVfAWLTaapSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGF 353
|
.
gi 488014886 342 G 342
Cdd:cd17368 354 S 354
|
|
| |
