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Conserved domains on  [gi|488043460|ref|WP_002114857|]
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MULTISPECIES: DNA-directed RNA polymerase subunit beta [Acinetobacter]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11478603)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1362 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


:

Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2204.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460    1 MAYSYTEKKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKTPknrEDIGLQAAFRSVFPIESYSGNAALEFVEYSLG 80
Cdd:PRK00405    1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPP---EDEGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   81 KPEFDVRECILRGSTYAAPMRVKIRLIIKDretksIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFD 160
Cdd:PRK00405   78 EPKYDVEECKERGLTYSAPLRVKLRLINKE-----TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  161 HDKGKThSSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKVPVYldmgsyq 240
Cdd:PRK00405  153 HDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFG------- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  241 idlvperlrgemaqfdiadndgkviveqgkrinarhvrqmeaaglTKLSVPDEYLYERITAENITLRD-GEVIA-ANTLL 318
Cdd:PRK00405  225 ---------------------------------------------KEIEVPVEYLLGKVLAEDIVDEEtGEVLAeANDEI 259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  319 SHEVmvklaeggvkqfnilftndidRGSFVADTLRADTTAGREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDL 398
Cdd:PRK00405  260 TEEL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDL 318
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  399 SPVGRMKFNRRLGRPYEvgtdqksrEVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLV 478
Cdd:PRK00405  319 SKVGRYKLNKKLGLDED--------EDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLS 390
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  479 RVERAVKERLSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRD 558
Cdd:PRK00405  391 RMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRD 470
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  559 VHQTHYGRVCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDAVEYLSAIEEVGTVIAQADSAVDKDGNL 638
Cdd:PRK00405  471 VHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRF 550
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  639 TEEFVSVRHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVA 718
Cdd:PRK00405  551 VDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVA 630
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  719 RDSGVCVIANRGGAIEYVDASRIVIRVneDEMIAGEAGVDIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPST 798
Cdd:PRK00405  631 RDSGAVVVAKRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPST 708
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  799 DMGELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESG 878
Cdd:PRK00405  709 DNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESG 788
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  879 IVYIGAEVTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRdglekddralaie 958
Cdd:PRK00405  789 IVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR------------- 855
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  959 kaqldayrkdlkeeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvf 1038
Cdd:PRK00405      --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1039 lkeksaeidekfaekkrkLATGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIV 1118
Cdd:PRK00405  856 ------------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIV 917
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1119 LNPLGVPSRMNVGQILETHLGMAAKGLGDKIekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlrag 1198
Cdd:PRK00405  918 LNPLGVPSRMNIGQILETHLGWAAKGLGIKF------------------------------------------------- 948
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1199 vplATPVFDGAEESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPL 1278
Cdd:PRK00405  949 ---ATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPL 1025
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1279 GGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIEL 1358
Cdd:PRK00405 1026 GGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVEL 1105

                  ....
gi 488043460 1359 KNGD 1362
Cdd:PRK00405 1106 LDED 1109
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1362 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2204.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460    1 MAYSYTEKKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKTPknrEDIGLQAAFRSVFPIESYSGNAALEFVEYSLG 80
Cdd:PRK00405    1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPP---EDEGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   81 KPEFDVRECILRGSTYAAPMRVKIRLIIKDretksIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFD 160
Cdd:PRK00405   78 EPKYDVEECKERGLTYSAPLRVKLRLINKE-----TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  161 HDKGKThSSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKVPVYldmgsyq 240
Cdd:PRK00405  153 HDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFG------- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  241 idlvperlrgemaqfdiadndgkviveqgkrinarhvrqmeaaglTKLSVPDEYLYERITAENITLRD-GEVIA-ANTLL 318
Cdd:PRK00405  225 ---------------------------------------------KEIEVPVEYLLGKVLAEDIVDEEtGEVLAeANDEI 259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  319 SHEVmvklaeggvkqfnilftndidRGSFVADTLRADTTAGREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDL 398
Cdd:PRK00405  260 TEEL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDL 318
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  399 SPVGRMKFNRRLGRPYEvgtdqksrEVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLV 478
Cdd:PRK00405  319 SKVGRYKLNKKLGLDED--------EDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLS 390
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  479 RVERAVKERLSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRD 558
Cdd:PRK00405  391 RMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRD 470
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  559 VHQTHYGRVCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDAVEYLSAIEEVGTVIAQADSAVDKDGNL 638
Cdd:PRK00405  471 VHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRF 550
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  639 TEEFVSVRHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVA 718
Cdd:PRK00405  551 VDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVA 630
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  719 RDSGVCVIANRGGAIEYVDASRIVIRVneDEMIAGEAGVDIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPST 798
Cdd:PRK00405  631 RDSGAVVVAKRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPST 708
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  799 DMGELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESG 878
Cdd:PRK00405  709 DNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESG 788
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  879 IVYIGAEVTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRdglekddralaie 958
Cdd:PRK00405  789 IVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR------------- 855
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  959 kaqldayrkdlkeeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvf 1038
Cdd:PRK00405      --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1039 lkeksaeidekfaekkrkLATGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIV 1118
Cdd:PRK00405  856 ------------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIV 917
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1119 LNPLGVPSRMNVGQILETHLGMAAKGLGDKIekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlrag 1198
Cdd:PRK00405  918 LNPLGVPSRMNIGQILETHLGWAAKGLGIKF------------------------------------------------- 948
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1199 vplATPVFDGAEESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPL 1278
Cdd:PRK00405  949 ---ATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPL 1025
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1279 GGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIEL 1358
Cdd:PRK00405 1026 GGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVEL 1105

                  ....
gi 488043460 1359 KNGD 1362
Cdd:PRK00405 1106 LDED 1109
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
8-1358 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1824.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460     8 KKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKTPKNREDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVR 87
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460    88 ECILRGSTYAAPMRVKIRLIIKdrETKSIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGkTH 167
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINK--EEDGTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKD-TT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   168 SSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQilnlfyekvpvyldmgsyqidlvper 247
Cdd:TIGR02013  158 KSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDT-------------------------- 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   248 lrgemaqfdiadndgkviveqgkrinarhvrqmeaagltklsvpdeylyeritaenitlrdgeviaantllshevmvkla 327
Cdd:TIGR02013      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   328 eggvkqfniLFTNDIDRGSFVADTLRADTTAGREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFN 407
Cdd:TIGR02013  212 ---------LILNRLGSGEYIRNTLRKDPTNSEEEALVEIYRKLRPGEPPTVEAARSLLENLFFDPKRYDLGRVGRYKLN 282
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   408 RRLGRPyevgtdqkSREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKER 487
Cdd:TIGR02013  283 KKLGLD--------VPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRER 354
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   488 LSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRV 567
Cdd:TIGR02013  355 MSTQDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRI 434
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   568 CPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRV--TDAVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSV 645
Cdd:TIGR02013  435 CPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEEDNYVIAQANAPLDENGRFVEDLVVA 514
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   646 RHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCV 725
Cdd:TIGR02013  515 RYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVI 594
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   726 IANRGGAIEYVDASRIVIRVNEDEMiAGEAGVDIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPSTDMGELAL 805
Cdd:TIGR02013  595 VAKRGGVVEYVDAKRIVIRYDEDEE-EPDGGIDIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELAL 673
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   806 GQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAE 885
Cdd:TIGR02013  674 GRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAE 753
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   886 VTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGlekddralaiekaqlday 965
Cdd:TIGR02013  754 VKAGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSREQ------------------ 815
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   966 rkdlkeeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksae 1045
Cdd:TIGR02013      --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1046 idekfaekkrklatGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVP 1125
Cdd:TIGR02013  816 --------------GDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVP 881
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1126 SRMNVGQILETHLGMAAKGLGDKiekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlraGVPLATPV 1205
Cdd:TIGR02013  882 SRMNIGQILETHLGWAGKRLGRK-------------------------------------------------GVPIATPV 912
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1206 FDGAEESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFG 1285
Cdd:TIGR02013  913 FDGASEEEIKEYLEKAGLPRDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFG 992
                         1290      1300      1310      1320      1330      1340      1350
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488043460  1286 GQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIEL 1358
Cdd:TIGR02013  993 GQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1362 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1629.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   12 RKNFGKLPQVMDAPYLLSIQVDSYRTFLqdgktpknreDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVRECIL 91
Cdd:COG0085     1 RWSFAKIKEPLELPNLLEIQLDSFNWFL----------EEGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   92 RGSTYAAPMRVKIRLIikDRETKSIKdvrEQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKthsSGK 171
Cdd:COG0085    71 RDLTYAAPLYVKVRLV--NKETGEIK---EQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDK---SGK 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  172 VLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGY-NNEQILNLFYEKVPvyldmgsyqidlvperlrg 250
Cdd:COG0085   143 DLYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLeTDEEILEAFGDDPI------------------- 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  251 emaqfdiadndgkviveqgkrinarhvrqmeaagltklsvpDEYLYEritaenitlrdgeviaantllshevmvklaegg 330
Cdd:COG0085   204 -----------------------------------------QEYILA--------------------------------- 209
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  331 vkqfnilftndidrgsfvadTLRADTTAGREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFNRRL 410
Cdd:COG0085   210 --------------------TLEKDNTKTQEEALLEIYRKLRPGEPPTIERAEQLLDNLFFDPKRYDLAHVGRYKINKKL 269
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  411 GrpyeVGTDQKSRevegILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQ 490
Cdd:COG0085   270 G----LDVPPEDR----VLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERMTT 341
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  491 AETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRVCPI 570
Cdd:COG0085   342 QDVEAITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPI 421
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  571 ETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDAVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGE 650
Cdd:COG0085   422 ETPEGPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVRYRGE 501
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  651 FVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLvgtgmeanvardsgvcvianrg 730
Cdd:COG0085   502 EVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAPL---------------------- 559
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  731 gaieyvdasrivirvnedemiageagvDIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPSTDMGELALGQNMR 810
Cdd:COG0085   560 ---------------------------LHYPLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLL 612
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  811 VAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVTAGD 890
Cdd:COG0085   613 VAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGD 692
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  891 ILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGlekddralaiekaqldayrkdlk 970
Cdd:COG0085   693 ILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSREE----------------------- 749
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  971 eeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekf 1050
Cdd:COG0085       --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1051 aekkrklatGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNV 1130
Cdd:COG0085   750 ---------GDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNV 820
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1131 GQILETHLGMAAKGLGDKIekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlragvplATPVFDGAE 1210
Cdd:COG0085   821 GQVLETHLGWAAALLGRRV----------------------------------------------------ATPVFDGAP 848
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1211 ESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFG 1290
Cdd:COG0085   849 EEEIRELLEKAGLPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFG 928
                        1290      1300      1310      1320      1330      1340      1350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488043460 1291 EMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIELKNGD 1362
Cdd:COG0085   929 EMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLGLDVEVLSED 1000
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1359 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 876.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   27 LLSIQVDSYRTFLQDGktpknredigLQAAFRSVFPIESYS--GNAALEFVEYSLGKP---------EFDVRECILRGST 95
Cdd:cd00653     1 LVKQQIDSFNYFLNVG----------LQEIVKSIPPITDTDddGRLKLKFGDIYLGKPkveeggvtrKLTPNECRLRDLT 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   96 YAAPMRVKIRLIIKDREtksikDVREQEVYMGEIPLMTE------------------------NGTFVINGTERVIVSQL 151
Cdd:cd00653    71 YSAPLYVDIRLTVNDKG-----KIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIINQE 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  152 HRSPGVFFDHDkgkthSSGKVLYSARIIP----YRGSWLDFEFDAKDlvyvridrrrkllatvvlralgynneqilnlfy 227
Cdd:cd00653   146 QRSPNVIIVED-----SKGKRIYTKTSIPsyspYRGSWLEVKSDKKK--------------------------------- 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  228 ekvpvyldmgsyqidlvperlrgemaqfdiadndgkviveqgKRINARHvrqmeaagltklsvpdeylyeritaenitlr 307
Cdd:cd00653   188 ------------------------------------------DRIYVRI------------------------------- 194
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  308 dgeviaantllshevmvklaeggvkqfnilftnDIDRgsfvadtlradttagREEALVEIYKvmrpgepptkeaaenlfn 387
Cdd:cd00653   195 ---------------------------------DLKR---------------QEEALKYIGK------------------ 208
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  388 nlffsserydlspvgrmKFnrrlgrpyevgtdqksrevegilshEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGE 467
Cdd:cd00653   209 -----------------RF-------------------------EDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGE 246
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  468 MTENQFRVGLVRVERAVKERLSQA--ETDNLSPQDLINAKPVAAAIKEFFGSSQ------------LSQFMDQNNPLSEI 533
Cdd:cd00653   247 LLQNLFRSGLKRLEREVKEKLQKQlsKKKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSEL 326
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  534 THKRRVSAlgpGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAKANdfGFLETPYRKVVdgrvtdave 613
Cdd:cd00653   327 SHKRRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVE--------- 392
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  614 ylsaieevgtviaqadsavdkdgnlteefvsvrhqgefvrmppEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSN 693
Cdd:cd00653   393 -------------------------------------------KEVTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSN 429
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  694 MQRQAVPT----------------LRADKPLVGTGMEANVARDsgvcvianrggaieyvdasrivirvnedemiageagv 757
Cdd:cd00653   430 MQKQAVGTpalnqqyrmdtklyllLYPQKPLVGTGIEEYIAFG------------------------------------- 472
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  758 diynlikytrsnqntcinqniivnlgdkvargdiladgpstdmgELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRL 837
Cdd:cd00653   473 --------------------------------------------ELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFF 508
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  838 TSIHIQELSCVARDTKLGAEEIT-ADIPNVGEAALSKLDESGIVYIGAEVTAGDILVGKVTPKGETQLTPeekllraIFG 916
Cdd:cd00653   509 RSIHYKKYEIELRKTKNGPEEITrGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP-------IFG 581
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  917 EKAADVKDSSLRVPSGTKGTVIDVQVFTRdglekddralaiekaqldayrkdlkeeykifeeaarervirllkgqesngg 996
Cdd:cd00653   582 EKARDVRDTSLKYPGGEKGIVDDVKIFSR--------------------------------------------------- 610
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  997 gstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekfaekkrklatgdELTTGVLKVVKVYLA 1076
Cdd:cd00653   611 -----------------------------------------------------------------ELNDGGNKLVKVYIR 625
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1077 VKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILETHLGMAAkglgdkiekmlkeq 1156
Cdd:cd00653   626 QKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAG-------------- 691
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1157 rtvlelrefldkiynkvggeqedldsltdaevlALSGNLRAGvplatPVFDGAEESQIKDLLELAGISRTGQTVLFDGRT 1236
Cdd:cd00653   692 ---------------------------------ALLGKFGDA-----TPFDGAEEEDISELLGEAGLNYYGKEVLYDGRT 733
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1237 GEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDD 1316
Cdd:cd00653   734 GEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDD 813
                        1370      1380      1390      1400      1410
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488043460 1317 VEGRTRIYKNIV----------DGNHYMDPGMPESFNVLTKEIRSLGINIELK 1359
Cdd:cd00653   814 VVARVCVKCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
726-1283 1.35e-161

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 488.96  E-value: 1.35e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   726 IANRGGAIEYVDASRIVIRVNEdemiaGEAGVDIYNLIKYTRSNQNT---CINQNIIVNLGdKVARGDiladgpstdMGE 802
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCAM-----GKQAMGIYTLNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGG---------FGE 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   803 LALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQElsCVARDTKLGA-EEITADIPNVGEAALSKLDESGIVY 881
Cdd:pfam00562   66 LPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKE--IEARKTKLGPiEEITRDIPNVSEEALKKLDEDGIVR 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   882 IGAEVTAGDILVGKVtpkGETQLTpeeKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTrdglekddralaiekaq 961
Cdd:pfam00562  144 VGAEVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFE----------------- 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   962 ldayrkdlkeeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflke 1041
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1042 ksaeidekfaekkrklatgdeLTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNP 1121
Cdd:pfam00562  201 ---------------------LPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNP 259
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1122 LGVPSRMNVGQILETHLGMAAKGLgdkiekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlraGVPL 1201
Cdd:pfam00562  260 HGVPSRMTIGQLLETHLGKAAALL----------------------------------------------------GVFV 287
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1202 ATPVFDGA--EESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLG 1279
Cdd:pfam00562  288 DATPFDGAstEVEDIGELLEKAGYNYYGKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLG 367

                   ....
gi 488043460  1280 GKAQ 1283
Cdd:pfam00562  368 GRAR 371
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1362 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2204.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460    1 MAYSYTEKKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKTPknrEDIGLQAAFRSVFPIESYSGNAALEFVEYSLG 80
Cdd:PRK00405    1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLQLDVPP---EDEGLEEVFRSIFPIEDFNGNLSLEFVSYELG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   81 KPEFDVRECILRGSTYAAPMRVKIRLIIKDretksIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFD 160
Cdd:PRK00405   78 EPKYDVEECKERGLTYSAPLRVKLRLINKE-----TGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  161 HDKGKThSSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKVPVYldmgsyq 240
Cdd:PRK00405  153 HDKDKT-SSGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGYSDEEILDLFYEKEEFG------- 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  241 idlvperlrgemaqfdiadndgkviveqgkrinarhvrqmeaaglTKLSVPDEYLYERITAENITLRD-GEVIA-ANTLL 318
Cdd:PRK00405  225 ---------------------------------------------KEIEVPVEYLLGKVLAEDIVDEEtGEVLAeANDEI 259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  319 SHEVmvklaeggvkqfnilftndidRGSFVADTLRADTTAGREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDL 398
Cdd:PRK00405  260 TEEL---------------------DGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDL 318
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  399 SPVGRMKFNRRLGRPYEvgtdqksrEVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLV 478
Cdd:PRK00405  319 SKVGRYKLNKKLGLDED--------EDVRVLTKEDIIATIKYLINLRNGKGEVDDIDHLGNRRVRSVGELLQNQFRIGLS 390
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  479 RVERAVKERLSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRD 558
Cdd:PRK00405  391 RMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLTRERAGFEVRD 470
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  559 VHQTHYGRVCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDAVEYLSAIEEVGTVIAQADSAVDKDGNL 638
Cdd:PRK00405  471 VHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVDGKVTDEIVYLTADEEDNYVIAQANAPLDEDGRF 550
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  639 TEEFVSVRHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVA 718
Cdd:PRK00405  551 VDELVTARYKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRPEAPLVGTGMERRVA 630
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  719 RDSGVCVIANRGGAIEYVDASRIVIRVneDEMIAGEAGVDIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPST 798
Cdd:PRK00405  631 RDSGAVVVAKRDGVVEYVDASRIVVRV--EELDPGEDGVDIYNLIKFQRSNQNTCINQRPIVKVGDRVEKGDVLADGPST 708
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  799 DMGELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESG 878
Cdd:PRK00405  709 DNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDESG 788
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  879 IVYIGAEVTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRdglekddralaie 958
Cdd:PRK00405  789 IVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVIDVKVFTR------------- 855
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  959 kaqldayrkdlkeeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvf 1038
Cdd:PRK00405      --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1039 lkeksaeidekfaekkrkLATGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIV 1118
Cdd:PRK00405  856 ------------------IEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIV 917
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1119 LNPLGVPSRMNVGQILETHLGMAAKGLGDKIekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlrag 1198
Cdd:PRK00405  918 LNPLGVPSRMNIGQILETHLGWAAKGLGIKF------------------------------------------------- 948
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1199 vplATPVFDGAEESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPL 1278
Cdd:PRK00405  949 ---ATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPL 1025
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1279 GGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIEL 1358
Cdd:PRK00405 1026 GGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPESFNVLVKELQSLGLDVEL 1105

                  ....
gi 488043460 1359 KNGD 1362
Cdd:PRK00405 1106 LDED 1109
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
8-1358 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1824.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460     8 KKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQDGKTPKNREDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVR 87
Cdd:TIGR02013    1 KKRIRIDFGKIPEVLEVPNLLEIQLDSYDWFLQQDTPPEKRKEEGLEEVFKSIFPIEDYTGNIELEYLSYRLGEPKYSVE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460    88 ECILRGSTYAAPMRVKIRLIIKdrETKSIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGkTH 167
Cdd:TIGR02013   81 ECKERGLTYSAPLKVKLRLINK--EEDGTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKD-TT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   168 SSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQilnlfyekvpvyldmgsyqidlvper 247
Cdd:TIGR02013  158 KSGKVLFSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDT-------------------------- 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   248 lrgemaqfdiadndgkviveqgkrinarhvrqmeaagltklsvpdeylyeritaenitlrdgeviaantllshevmvkla 327
Cdd:TIGR02013      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   328 eggvkqfniLFTNDIDRGSFVADTLRADTTAGREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFN 407
Cdd:TIGR02013  212 ---------LILNRLGSGEYIRNTLRKDPTNSEEEALVEIYRKLRPGEPPTVEAARSLLENLFFDPKRYDLGRVGRYKLN 282
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   408 RRLGRPyevgtdqkSREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKER 487
Cdd:TIGR02013  283 KKLGLD--------VPESIGVLTKEDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRER 354
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   488 LSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRV 567
Cdd:TIGR02013  355 MSTQDTDTLTPQDLINAKPISAAIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRI 434
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   568 CPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRV--TDAVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSV 645
Cdd:TIGR02013  435 CPIETPEGPNIGLINSLSTYARVNEYGFIETPYRKVKDGKVvvTDEIDYLTADEEDNYVIAQANAPLDENGRFVEDLVVA 514
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   646 RHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCV 725
Cdd:TIGR02013  515 RYRGEITLVSPDQVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVI 594
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   726 IANRGGAIEYVDASRIVIRVNEDEMiAGEAGVDIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPSTDMGELAL 805
Cdd:TIGR02013  595 VAKRGGVVEYVDAKRIVIRYDEDEE-EPDGGIDIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELAL 673
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   806 GQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAE 885
Cdd:TIGR02013  674 GRNVLVAFMPWNGYNYEDAILISERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAE 753
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   886 VTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGlekddralaiekaqlday 965
Cdd:TIGR02013  754 VKAGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSREQ------------------ 815
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   966 rkdlkeeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksae 1045
Cdd:TIGR02013      --------------------------------------------------------------------------------
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1046 idekfaekkrklatGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVP 1125
Cdd:TIGR02013  816 --------------GDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSKILPIEDMPFLEDGTPVDIVLNPLGVP 881
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1126 SRMNVGQILETHLGMAAKGLGDKiekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlraGVPLATPV 1205
Cdd:TIGR02013  882 SRMNIGQILETHLGWAGKRLGRK-------------------------------------------------GVPIATPV 912
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1206 FDGAEESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFG 1285
Cdd:TIGR02013  913 FDGASEEEIKEYLEKAGLPRDGKVRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFG 992
                         1290      1300      1310      1320      1330      1340      1350
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488043460  1286 GQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIEL 1358
Cdd:TIGR02013  993 GQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1362 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 1629.81  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   12 RKNFGKLPQVMDAPYLLSIQVDSYRTFLqdgktpknreDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVRECIL 91
Cdd:COG0085     1 RWSFAKIKEPLELPNLLEIQLDSFNWFL----------EEGLQEIFDEISPIEDFTGNLSLEFGDYRLGEPKYTPEECKE 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   92 RGSTYAAPMRVKIRLIikDRETKSIKdvrEQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKthsSGK 171
Cdd:COG0085    71 RDLTYAAPLYVKVRLV--NKETGEIK---EQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDK---SGK 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  172 VLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGY-NNEQILNLFYEKVPvyldmgsyqidlvperlrg 250
Cdd:COG0085   143 DLYSAKVIPSRGAWLEFETDKDGTIYVRIDRKRKIPVTVLLRALGLeTDEEILEAFGDDPI------------------- 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  251 emaqfdiadndgkviveqgkrinarhvrqmeaagltklsvpDEYLYEritaenitlrdgeviaantllshevmvklaegg 330
Cdd:COG0085   204 -----------------------------------------QEYILA--------------------------------- 209
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  331 vkqfnilftndidrgsfvadTLRADTTAGREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFNRRL 410
Cdd:COG0085   210 --------------------TLEKDNTKTQEEALLEIYRKLRPGEPPTIERAEQLLDNLFFDPKRYDLAHVGRYKINKKL 269
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  411 GrpyeVGTDQKSRevegILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQ 490
Cdd:COG0085   270 G----LDVPPEDR----VLTAEDIVATIKYLLELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERMTT 341
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  491 AETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRVCPI 570
Cdd:COG0085   342 QDVEAITPQSLINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPI 421
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  571 ETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDAVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGE 650
Cdd:COG0085   422 ETPEGPNIGLIGSLALYARVNEYGFIETPYRKVENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVRYRGE 501
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  651 FVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLvgtgmeanvardsgvcvianrg 730
Cdd:COG0085   502 EVLVPPEEVDYMDVSPKQIVSVATSLIPFLEHDDANRALMGANMQRQAVPLLRPEAPL---------------------- 559
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  731 gaieyvdasrivirvnedemiageagvDIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPSTDMGELALGQNMR 810
Cdd:COG0085   560 ---------------------------LHYPLQKFQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLL 612
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  811 VAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVTAGD 890
Cdd:COG0085   613 VAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEEYEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGD 692
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  891 ILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGlekddralaiekaqldayrkdlk 970
Cdd:COG0085   693 ILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLRVPHGEKGKVIDVKVFSREE----------------------- 749
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  971 eeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekf 1050
Cdd:COG0085       --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1051 aekkrklatGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNV 1130
Cdd:COG0085   750 ---------GDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVDIVLNPLGVPSRMNV 820
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1131 GQILETHLGMAAKGLGDKIekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlragvplATPVFDGAE 1210
Cdd:COG0085   821 GQVLETHLGWAAALLGRRV----------------------------------------------------ATPVFDGAP 848
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1211 ESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFG 1290
Cdd:COG0085   849 EEEIRELLEKAGLPPDGKEVLYDGRTGEPFDNPVTVGYMYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFG 928
                        1290      1300      1310      1320      1330      1340      1350
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488043460 1291 EMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIELKNGD 1362
Cdd:COG0085   929 EMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLGLDVEVLSED 1000
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
1-1358 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 1427.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460    1 MAYSYTEKKRIRKNFGKLPQVMDAPYLLSIQVDSYRTFLQdgktPKNREDIGLQAAFRSVFPIESYSGNAALEFVEYSLG 80
Cdd:PRK09603    1 MSKKIPLKNRLRADFTKTPTDLEVPNLLLLQRDSYDSFLY----SKDGKESGIEKVFKSIFPIQDEHNRITLEYAGCEFG 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   81 KPEFDVRECILRGSTYAAPMRVKIRLIIKDRETKS-----IKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSP 155
Cdd:PRK09603   77 KSKYTVREAMERGITYSIPLKIKVRLILWEKDTKSgekngIKDIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  156 GVFFDHDKGKThSSGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKVPVYLD 235
Cdd:PRK09603  157 GVIFKEEESST-SLNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDYQKQDIIKMFYPLVKVRYE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  236 MGSYQIDLVPERLRGEMaQFDIADNDGKVIVEQGKRINARHVRQMEAAGLTKLSVPDEYLYERITAENITlrDGEVIAAN 315
Cdd:PRK09603  236 NDKYLIPFASLDANQRM-EFDLKDPQGKIILLAGKKLTSRKIKELKENHLEWVEYPMDILLNRHLAEPVM--VGKEVLLD 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  316 TL--LSHEVMVKLAEGGVKQFNIlfTNDIDRG-------SFVADT-----LRADTTAGREEAL--VEIYKVMRPGEPPTK 379
Cdd:PRK09603  313 MLtqLDKNKLEKIHDLGVQEFVI--INDLALGhdasiihSFSADSeslklLKQTEKIDDENALaaIRIHKVMKPGDPVTT 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  380 EAAENLFNNLFFSSERYDLSPVGRMKFNRRLGrpYEVgtdqksREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGN 459
Cdd:PRK09603  391 EVAKQFVKKLFFDPERYDLTMVGRMKMNHKLG--LHV------PDYITTLTHEDIITTVKYLMKIKNNQGKIDDRDHLGN 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  460 RRVRSVGEMTENQFRVGLVRVERAVKERLS--QAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKR 537
Cdd:PRK09603  463 RRIRAVGELLANELHSGLVKMQKTIKDKLTtmSGAFDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKR 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  538 RVSALGPGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDAVEYLSA 617
Cdd:PRK09603  543 RLSALGEGGLVKDRVGFEARDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKVVDGKVVGETIYLTA 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  618 IEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQ 697
Cdd:PRK09603  623 IQEDSHIIAPASTPIDEEGNILGDLIETRVEGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQ 702
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  698 AVPTLRADKPLVGTGMEANVARDSGVCVIANRGGAIEYVDASRIVIrVNEDEmiaGEAGVDIYNLIKYTRSNQNTCINQN 777
Cdd:PRK09603  703 AVPLLRSDAPIVGTGIEKIIARDSWGAIKANRAGVVEKIDSKNIYI-LGEGK---EEAYIDAYSLQKNLRTNQNTSFNQV 778
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  778 IIVNLGDKVARGDILADGPSTDMGELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAE 857
Cdd:PRK09603  779 PIVKVGDKVEAGQIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSTHIYEKEVDARELKHGVE 858
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  858 EITADIPNVGEAALSKLDESGIVYIGAEVTAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTV 937
Cdd:PRK09603  859 EFTADIPDVKEEALAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTV 938
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  938 IDVQVFTRDGLEKDDRALAI---EKAQLDAyrkdlkEEYKIFEEAARERVIRL--------LKGQESNGGGSTKRGDKLV 1006
Cdd:PRK09603  939 IDVKVFTKKGYEKDARVLSAyeeEKAKLDM------EHFDRLTMLNREELLRVssllsqaiLEEPFSHNGKDYKEGDQIP 1012
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1007 EEVLSGLELVDLLE-IQPADEAIAERLTQIQVFLKEKSAEIDEKFAEKKRKLATGDELTTGVLKVVKVYLAVKRRIQPGD 1085
Cdd:PRK09603 1013 KEEIASINRFTLASlVKKYSKEVQNHYEITKNNFLEQKKVLGEEHEEKLSILEKDDILPNGVIKKVKLYIATKRKLKVGD 1092
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1086 KMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILETHLGMAAKGLGDKIEKMLKEQRT--VLELR 1163
Cdd:PRK09603 1093 KMAGRHGNKGIVSNIVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGKQIASMLEDKTKdfAKELR 1172
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1164 ----EFLDKIYNKVGGEQEDLDSLTDAEVLALSGNLRAGVPLATPVFDGAEESQIKDLLELAGISRTGQTVLFDGRTGEQ 1239
Cdd:PRK09603 1173 akmlEIANAINEKDPLTIHALENCSDEELLEYAKDWSKGVKMAIPVFEGISQEKFYKLFELAKIAMDGKMDLYDGRTGEK 1252
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1240 FDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVEG 1319
Cdd:PRK09603 1253 MRERVNVGYMYMIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRG 1332
                        1370      1380      1390
                  ....*....|....*....|....*....|....*....
gi 488043460 1320 RTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIEL 1358
Cdd:PRK09603 1333 RENAYRAIAKGEQVGESEIPETFYVLTKELQSLALDINI 1371
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
27-1362 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 1378.56  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   27 LLSIQVDSYRTFlqdgkTPKNREDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDVRECILRGSTYAAPMRVKIRL 106
Cdd:PRK14844   32 LVKVQKESYDSF-----TPKNKGNERLEVIFHTIFPINDPLHRATIEFISCRVDDPKYDESECIKRGITFSAQVIASIRL 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  107 IIKD-----RETKSIKD-------------VREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKTHS 168
Cdd:PRK14844  107 VIMQdgislDEYKSIKEsgdhsklatviksIEEQEVHFCELPMMTDKGTFIINGVEKVIVSQMHRSPGVFFDSDKGKTYN 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  169 SGKVLYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQILNLFYEKVPVYLDMGSYQIDLVPERL 248
Cdd:PRK14844  187 SGKLIYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKALGLSNNDILDRFYEKIKYIKHKDGWKVPFVPDKF 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  249 RGEMAQFDIADNDGKVIVEQGKRINARHVRQMEAAGLTKLSVPDEYLYERITAENI--TLRDGEVIAANTLLSHEVMVKL 326
Cdd:PRK14844  267 KGVRLPFDLMDVEGNVLLKANVRITSRLAKKLYDNELKEYLVPFDSICGLFLAEDLidSASSTKILSAGESIKLEDIKKL 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  327 AEGGVKQFNILFTNDIDRGSFVADTLRADTTAGREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKF 406
Cdd:PRK14844  347 ELLSIDEISVLNIDNLSVGPYILNTLFLDENMSYQDALYEIYKVLRPGEVPVLEIVEEFFRNLFFSPEYYDLSNIGRLKL 426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  407 NRRLGRPYEvgtdqksrEVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKE 486
Cdd:PRK14844  427 NSYLGLNYD--------EDLTVLTHEDIIEIVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEFIENQFRTGLLKLERAVVD 498
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  487 RLSQAETDNLSPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGR 566
Cdd:PRK14844  499 SMSTSSLDKVSPSDFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRERAGFEVRDVHPTHYGR 578
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  567 VCPIETPEGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDAVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVR 646
Cdd:PRK14844  579 ICPIETPEGQNIGLINSLAIYARINKYGFIESPYRKVVNRVVTDQIEYLSAIDEGLYYIADTSAKLDENNCFVDDMLYCR 658
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  647 HQGEFVRMPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCVI 726
Cdd:PRK14844  659 YAGSFVMVSSDQVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTAPLVATGMESFVASGSGAVVL 738
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  727 ANRGGAIEYVDASRIVIRVNEDEMIaGEAGVDIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPSTDMGELALG 806
Cdd:PRK14844  739 AKRDGIVDSSDSNSIVIRAFDKERV-NYLDVDIYHLRKFQRSNHNTCINQKPLVCVGDYVKEGDVIADGPAINSGELALG 817
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  807 QNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEV 886
Cdd:PRK14844  818 QNLLVAFMSWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEKITRAIPGVNEENLYHLDDSGIVKIGTRV 897
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  887 TAGDILVGKVTPKGETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGLEKDDRALAIEKAQLDayr 966
Cdd:PRK14844  898 GPGYILVGKVTPKPSLSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQVFTRRGVEENERALLIKQKEIN--- 974
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  967 kDLKEEYKIFEEAARERVIRLLKGQESNGGGSTKrgdklveEVLSGLELVDLLEIQPADEAIAERLTQIQVFLKEKSAEI 1046
Cdd:PRK14844  975 -DFEKERDYIINVTSEYFYDELKKLLINSGSQDR-------EKFDSIEREQWWGIGLKNQSISEQVKSLKKDFDEKVSHA 1046
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1047 DEKFAEKKRKLATGDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPS 1126
Cdd:PRK14844 1047 IAQFKRKVEKLHEGYDLPQGVSMSVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIILNPLGVPS 1126
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1127 RMNVGQILETHLGMAAKGLGDKIEKML----------------------------------------------------- 1153
Cdd:PRK14844 1127 RMNVGQILETHVGWACKKLGEKVGNILdeinkiksafckgirslnddnftkfaaayldnkkienidddeitasvlntpnk 1206
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1154 ----KEQRTVLE------------LREFLDKIYNkVGGEQE---DLDSLTDAEVLALSGNLRAGVPLATPVFDGAEESQI 1214
Cdd:PRK14844 1207 nalnDELNELVEnylnscksaysnLRNFLIEVYS-CGSNVSicnNIRDISDNNLIEFARKLRDGIPVAAPVFEGPKDEQI 1285
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1215 KDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEV 1294
Cdd:PRK14844 1286 AKLFELAGLDNSGQAVLYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHFGGQRFGEMEC 1365
                        1370      1380      1390      1400      1410      1420
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488043460 1295 WALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIELKNGD 1362
Cdd:PRK14844 1366 WALQAYGAAYTLQEMLTVKSDDINGRVKIYESIIKGDSNFECGIPESFNVMIKELRSLCLNVDLKQND 1433
rpoB CHL00207
RNA polymerase beta subunit; Provisional
25-1360 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1065.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   25 PYLLSIQVDSYRTFLQDGktpknredigLQAAFRSVFPIESYSGNAALEFV--EYSLGKPEFDVRECILRGSTYAAPMRV 102
Cdd:CHL00207    8 PDFLEIQRTSFCWFLNEG----------LNEELNIFSKIFDYTGNLELLLFgkNYKLKYPKYNLLSAKSYDSNYSIQIYL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  103 KIRLIIKDretksIKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKTHssgKVLYSARIIPYR 182
Cdd:CHL00207   78 PLKFINLK-----TNKIKFINYLIGNLPKMTQRGTFIINGLERVIVSQIIRSPGIYFKKEIKKNS---NKIYSATLIPNR 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  183 GSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQIL-NLFYEKVPVYLDMGSYQIDLVPerlrgemaqfdiadnd 261
Cdd:CHL00207  150 GSWIKFELDKNKEIWIRIDKNRKKPLIIFLKALGLTDQDIYsRLTKSEFLKKLKPILLNSNSYT---------------- 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  262 gkviveqgkrinarhvrqmeaagltklsvpdeylyeritaenitlrdgeviaantllshevmvklaeggvkqfnilftnd 341
Cdd:CHL00207      --------------------------------------------------------------------------------
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  342 idrgsfvadtlradttagREEALVEIYKVMRPGEPPTKEAAENLFNNLFFSSERYDLSPVGRMKFNRRLgrpyevgtDQK 421
Cdd:CHL00207  214 ------------------NEEILLEIYKNLSPIEPATVNDANQNLFSRFFDPKNYDLGKVGRYKINNKL--------NLN 267
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  422 SREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQAETDNLSPQDL 501
Cdd:CHL00207  268 IPERVRNLTYEDILSIIDKLINLKINKGNFDDIDHLKNRRVRSVGELLQNQFRIGLKRLERILRNRMTICDIDSLSKFNL 347
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  502 INAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLI 581
Cdd:CHL00207  348 INPKPLIALIREFFGSSQLSQYMDQTNPLSELTHKRRISILGPGGLDKDRISFAVRDIHPSHYGRICPIETPEGPNCGLI 427
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  582 NSLSVYAKANDFGFLETPYRKVVDGRV--TDAVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGEFVRMPPEKV 659
Cdd:CHL00207  428 GSLATNARINKFGFIETPFYKVINGKVkkFGNPIYLTADSEDLYRIAPNDINLNKNNYFKKNIIPVRYKQEFKTVNPSKV 507
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  660 THMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCVIANRGGAIEYVDAS 739
Cdd:CHL00207  508 DFIAISPIQVFSIAESLIPFLEHNDANRALMGSNMQRQAVPLLYPEKPIVGTGYEKQIALDSGMTIISLTEGIVVSVSAY 587
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  740 RIVIRVNEDEMIageagvdIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPSTDMGELALGQNMRVAFMTWNGY 819
Cdd:CHL00207  588 KIIIQDDNNRYI-------HYYLQKYQRSNQNTCINYRPIVWVGEKINIGQILADGSDIDNSELALGQNVLVAYMPWEGY 660
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  820 NYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVTAGDILVGKVTPK 899
Cdd:CHL00207  661 NFEDAILINKRLVYEDLFTSIHIEKYEIELRQTKLGSEEITRNIPNVSEYSLKNLDENGIISIGSKVLAGDILVGKITPK 740
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  900 GETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDglekddralaiekaqldayrkdlkeeykifeea 979
Cdd:CHL00207  741 GESDQLPEGKLLRAIFGEKAKDVKDTSLRMPNGGYGRVIKVEIFSRS--------------------------------- 787
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  980 arervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekfaekkrklaT 1059
Cdd:CHL00207  788 -------------------------------------------------------------------------------K 788
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1060 GDELTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILETHLG 1139
Cdd:CHL00207  789 GDELKFGYYLKIRVFIAQIRKIQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVPSRMNVGQLFECLLG 868
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1140 MAakglGDKIEKMLKeqrtVLELREFLDKIYNKVggeqedldsltdaevlaLSGN-LRagvplatpvfdgaEESQIKDLL 1218
Cdd:CHL00207  869 LA----GDNLNKRFK----ILPFDEMYGSEYSRI-----------------LINNkLN-------------QASIKNNEY 910
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1219 ELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALE 1298
Cdd:CHL00207  911 WLFNSYHPGKMVLRDGRTGYKFKNPVTVGIAYMLKLIHLVDDKIHARTTGPYSLVTQQPLGGKAQHGGQRFGEMEVWALE 990
                        1290      1300      1310      1320      1330      1340
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488043460 1299 AYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDPGMPESFNVLTKEIRSLGINIELKN 1360
Cdd:CHL00207  991 AFGAAYTLKELLTIKSDDMQGRNETLNAIVKGQPIPKPGTPESFKVLMRELQSLGLDIEAYK 1052
rpoB CHL00001
RNA polymerase beta subunit
25-1357 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1053.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   25 PYLLSIQVDSYRTFLqdgktpknreDIGLQAAFRSVFPIESYSGNAALEFV--EYSLGKPEFDVRECILRGSTYAAPMRV 102
Cdd:CHL00001   13 PGFNQIQFEGFCRFI----------DQGLTEELSKFPKIEDTDQEIEFQLFveTYQLVEPLIKERDAVYESLTYSSELYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  103 KIRLIIKDRetksiKDVREQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFF----DHdkgkthsSGKVLYSARI 178
Cdd:CHL00001   83 PAGLIWKKS-----RDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYrselDH-------NGISVYTGTI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  179 IPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALGYNNEQIL-NLFYekvpvyldmgsyqidlvPERLrgemaqfdi 257
Cdd:CHL00001  151 ISDWGGRLELEIDRKARIWARVSRKQKISILVLLSAMGLNLREILdNVCY-----------------PEIF--------- 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  258 adndgkviveqgkrinarhvrqmeaagltkLSVPDEYLYERITaenitlrdgeviaantllshevmvklaeggvkqfnil 337
Cdd:CHL00001  205 ------------------------------LSFLNDKEKKKIG------------------------------------- 217
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  338 ftndidrgsfvadtlradttaGREEALVEIYK--VMRPGEPPTKEAAENLFNNLFFSSeRYDLSPVGRMKFNRRLGRPye 415
Cdd:CHL00001  218 ---------------------SKENAILEFYQqfACVGGDPVFSESLCKELQKKFFQQ-RCELGRIGRRNMNRKLNLD-- 273
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  416 vgtdqkSREVEGILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQAETDN 495
Cdd:CHL00001  274 ------IPENNTFLLPQDVLAAADYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQDQFGLALNRLENAVRGTICGAIRRK 347
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  496 L--SPQDLINAKPVAAAIKEFFGSSQLSQFMDQNNPLSEITHKRRVSALGPGGLTRERAGFEVRDVHQTHYGRVCPIETP 573
Cdd:CHL00001  348 LipTPQNLVTSTPLTTTYESFFGSHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTS 427
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  574 EGPNIGLINSLSVYAKANDFGFLETPYRKVVDGRVTDAVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGEFVR 653
Cdd:CHL00001  428 EGINAGLIGSLAIHARIGHWGSLESPFYEISERSKEERMVYLSPSEDEYYMIAAGNSLALNQGIQEEQVVPARYRQEFLT 507
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  654 MPPEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLRADKPLVGTGMEANVARDSGVCVIANRGGAI 733
Cdd:CHL00001  508 IAWEQIHLRSIFPFQYFSIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKI 587
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  734 EYVDASRIVIRVNEDEMiageagvdIYNLIKYTRSNQNTCINQNIIVNLGDKVARGDILADGPSTDMGELALGQNMRVAF 813
Cdd:CHL00001  588 IYTDTDKIILSGNGDTL--------SIPLVMYQRSNKNTCMHQKPQVRRGKCVKKGQILADGAATVGGELALGKNVLVAY 659
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  814 MTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVARDTKLGAEEITADIPNVGEAALSKLDESGIVYIGAEVTAGDILV 893
Cdd:CHL00001  660 MPWEGYNFEDAVLISERLVYEDIYTSFHIRKYEIQTHVTSQGPERITKEIPHLEAHLLRNLDKNGIVMLGSWVETGDILV 739
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  894 GKVTPK--GETQLTPEEKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTRDGLEKDDRalaiekaqldayrkdlke 971
Cdd:CHL00001  740 GKLTPQeaEESSYAPEGRLLRAIFGIQVSTSKETCLKLPIGGRGRVIDVRWIQKKGGSSYNP------------------ 801
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  972 eykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekfa 1051
Cdd:CHL00001      --------------------------------------------------------------------------------
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1052 ekkrklatgdelttgvlKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVG 1131
Cdd:CHL00001  802 -----------------ETIHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDMPYLQDGTPVDMVLNPLGVPSRMNVG 864
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1132 QILETHLGMAAkglgdkieKMLKEQRTVLElrefLDKIYnkvggEQEdldsltDAEVLALSGNLRAGVPLATP-VFDgae 1210
Cdd:CHL00001  865 QIFECLLGLAG--------DLLNRHYRIAP----FDERY-----EQE------ASRKLVFSELYEASKQTANPwVFE--- 918
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1211 esqikdlLELAGISRtgqtvLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFG 1290
Cdd:CHL00001  919 -------PEYPGKSR-----LFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVG 986
                        1290      1300      1310      1320      1330      1340
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488043460 1291 EMEVWALEAYGAAYTLQEMLTVKSDDVEGRTRIYKNIVDGNHYMDP-GMPESFNVLTKEIRSLGINIE 1357
Cdd:CHL00001  987 EMEVWALEGFGVAYILQEMLTYKSDHIRARQEVLGAIITGGTIPKPeDAPESFRLLVRELRSLALELN 1054
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1359 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 876.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   27 LLSIQVDSYRTFLQDGktpknredigLQAAFRSVFPIESYS--GNAALEFVEYSLGKP---------EFDVRECILRGST 95
Cdd:cd00653     1 LVKQQIDSFNYFLNVG----------LQEIVKSIPPITDTDddGRLKLKFGDIYLGKPkveeggvtrKLTPNECRLRDLT 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   96 YAAPMRVKIRLIIKDREtksikDVREQEVYMGEIPLMTE------------------------NGTFVINGTERVIVSQL 151
Cdd:cd00653    71 YSAPLYVDIRLTVNDKG-----KIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIINQE 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  152 HRSPGVFFDHDkgkthSSGKVLYSARIIP----YRGSWLDFEFDAKDlvyvridrrrkllatvvlralgynneqilnlfy 227
Cdd:cd00653   146 QRSPNVIIVED-----SKGKRIYTKTSIPsyspYRGSWLEVKSDKKK--------------------------------- 187
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  228 ekvpvyldmgsyqidlvperlrgemaqfdiadndgkviveqgKRINARHvrqmeaagltklsvpdeylyeritaenitlr 307
Cdd:cd00653   188 ------------------------------------------DRIYVRI------------------------------- 194
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  308 dgeviaantllshevmvklaeggvkqfnilftnDIDRgsfvadtlradttagREEALVEIYKvmrpgepptkeaaenlfn 387
Cdd:cd00653   195 ---------------------------------DLKR---------------QEEALKYIGK------------------ 208
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  388 nlffsserydlspvgrmKFnrrlgrpyevgtdqksrevegilshEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGE 467
Cdd:cd00653   209 -----------------RF-------------------------EDLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGE 246
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  468 MTENQFRVGLVRVERAVKERLSQA--ETDNLSPQDLINAKPVAAAIKEFFGSSQ------------LSQFMDQNNPLSEI 533
Cdd:cd00653   247 LLQNLFRSGLKRLEREVKEKLQKQlsKKKDLTPQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSEL 326
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  534 THKRRVSAlgpGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAKANdfGFLETPYRKVVdgrvtdave 613
Cdd:cd00653   327 SHKRRISS---LGLFRERKGFEVRDLHPSHWGRICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVE--------- 392
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  614 ylsaieevgtviaqadsavdkdgnlteefvsvrhqgefvrmppEKVTHMDVSAQQVVSVAASLIPFLEHDDANRALMGSN 693
Cdd:cd00653   393 -------------------------------------------KEVTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSN 429
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  694 MQRQAVPT----------------LRADKPLVGTGMEANVARDsgvcvianrggaieyvdasrivirvnedemiageagv 757
Cdd:cd00653   430 MQKQAVGTpalnqqyrmdtklyllLYPQKPLVGTGIEEYIAFG------------------------------------- 472
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  758 diynlikytrsnqntcinqniivnlgdkvargdiladgpstdmgELALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRL 837
Cdd:cd00653   473 --------------------------------------------ELPLGQNAIVAVMSYSGYNFEDAIIINKSSVDRGFF 508
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  838 TSIHIQELSCVARDTKLGAEEIT-ADIPNVGEAALSKLDESGIVYIGAEVTAGDILVGKVTPKGETQLTPeekllraIFG 916
Cdd:cd00653   509 RSIHYKKYEIELRKTKNGPEEITrGDIPNVSEEKLKNLDEDGIIRPGARVEPGDILVGKITPKGETESTP-------IFG 581
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  917 EKAADVKDSSLRVPSGTKGTVIDVQVFTRdglekddralaiekaqldayrkdlkeeykifeeaarervirllkgqesngg 996
Cdd:cd00653   582 EKARDVRDTSLKYPGGEKGIVDDVKIFSR--------------------------------------------------- 610
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  997 gstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekfaekkrklatgdELTTGVLKVVKVYLA 1076
Cdd:cd00653   611 -----------------------------------------------------------------ELNDGGNKLVKVYIR 625
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1077 VKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILETHLGMAAkglgdkiekmlkeq 1156
Cdd:cd00653   626 QKRKPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAG-------------- 691
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1157 rtvlelrefldkiynkvggeqedldsltdaevlALSGNLRAGvplatPVFDGAEESQIKDLLELAGISRTGQTVLFDGRT 1236
Cdd:cd00653   692 ---------------------------------ALLGKFGDA-----TPFDGAEEEDISELLGEAGLNYYGKEVLYDGRT 733
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1237 GEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDD 1316
Cdd:cd00653   734 GEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGEMERDALIAHGAAYLLQERLTIKSDD 813
                        1370      1380      1390      1400      1410
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488043460 1317 VEGRTRIYKNIV----------DGNHYMDPGMPESFNVLTKEIRSLGINIELK 1359
Cdd:cd00653   814 VVARVCVKCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRLK 866
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
726-1283 1.35e-161

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 488.96  E-value: 1.35e-161
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   726 IANRGGAIEYVDASRIVIRVNEdemiaGEAGVDIYNLIKYTRSNQNT---CINQNIIVNLGdKVARGDiladgpstdMGE 802
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQCAM-----GKQAMGIYTLNKFYRSDQNTyvlCYPQKPLVKTG-AVEAGG---------FGE 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   803 LALGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQElsCVARDTKLGA-EEITADIPNVGEAALSKLDESGIVY 881
Cdd:pfam00562   66 LPLGQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKE--IEARKTKLGPiEEITRDIPNVSEEALKKLDEDGIVR 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   882 IGAEVTAGDILVGKVtpkGETQLTpeeKLLRAIFGEKAADVKDSSLRVPSGTKGTVIDVQVFTrdglekddralaiekaq 961
Cdd:pfam00562  144 VGAEVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFE----------------- 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   962 ldayrkdlkeeykifeeaarervirllkgqesngggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflke 1041
Cdd:pfam00562      --------------------------------------------------------------------------------
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1042 ksaeidekfaekkrklatgdeLTTGVLKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNP 1121
Cdd:pfam00562  201 ---------------------LPPGGIKMVKVYIRQKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNP 259
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1122 LGVPSRMNVGQILETHLGMAAKGLgdkiekmlkeqrtvlelrefldkiynkvggeqedldsltdaevlalsgnlraGVPL 1201
Cdd:pfam00562  260 HGVPSRMTIGQLLETHLGKAAALL----------------------------------------------------GVFV 287
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1202 ATPVFDGA--EESQIKDLLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLG 1279
Cdd:pfam00562  288 DATPFDGAstEVEDIGELLEKAGYNYYGKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLG 367

                   ....
gi 488043460  1280 GKAQ 1283
Cdd:pfam00562  368 GRAR 371
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
31-1362 1.71e-86

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 306.50  E-value: 1.71e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   31 QVDSYRTFLqdgktpknreDIGLQAAFRSVFPIESYSGNAALEFVEYSLGKPEFDV----------RECILRGSTYAAPM 100
Cdd:PRK08565   18 HLDSYNDFI----------ERGLQEIVDEFGEIKTEIPGLKIVLGKIRVGEPEIKEadgserpitpMEARLRNLTYAAPL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  101 RVKIRLIIKDRETKsikdvrEQEVYMGEIPLMTEN------------------------GTFVINGTERVIVSQLHRSPG 156
Cdd:PRK08565   88 YLTMIPVENGIEYE------PEEVKIGDLPIMVKSkicplsglspdelieigedpkdpgGYFIINGSERVIVSQEDLAPN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  157 -VFFDHDKgkthSSGKVLYSARIIPYRGSWLdfefdakdlVYVRIDRRRKLLATVVLRALGYnneqilnlfyeKVPVyld 235
Cdd:PRK08565  162 rVLVDKGE----AGSSITHTAKVISSRAGYR---------AQVTVERRKDGTIYVSFPAVPG-----------KIPF--- 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  236 mgsyqidlvperlrgemaqfdiadndgkVIVeqgkrinarhvrqMEAAGLtklsvpdeylyeritaenitLRDGEVIAAn 315
Cdd:PRK08565  215 ----------------------------VIL-------------MRALGL--------------------ETDRDIVYA- 232
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  316 TLLSHEVMvklaeggvkqfNILFTNdIDRGSFVADTlradttagREEALVEIYKVMRPGEPPTK--EAAENLFNNLFFss 393
Cdd:PRK08565  233 VSLDPEIQ-----------QELLPS-LEQASSIAAT--------VEDALDYIGKRVAIGQPREYriERAEQILDKYLL-- 290
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  394 erydlspvgrmkfnrrlgrPYeVGTDQKSREVEGILshedIIDVLRTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQF 473
Cdd:PRK08565  291 -------------------PH-LGTSPEDRIKKAYF----LGQMASKLLELYLGRREPDDKDHYANKRLRLAGDLLAELF 346
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  474 RVGLVRVERAVKERL--SQAETDNLSPQDLINAKPVAAAIKEFF-------GSSQLSQFMDQNNPLSEITHKRRVsaLGP 544
Cdd:PRK08565  347 RVAFKQLVKDLKYQLekSYARGRKLDLRAIVRPDIITERIRHALatgnwvgGRTGVSQLLDRTNYLSTLSHLRRV--VSP 424
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  545 ggLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSL-------------SVYAKANDFGF------LETPY----R 601
Cdd:PRK08565  425 --LSRGQPHFEARDLHGTQWGRICPFETPEGPNCGLVKNLalmaqisvgvdeeEVEEILYELGVvpveeaREEEYiswsR 502
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  602 KVVDGR----VTDAVEYLSAI--------------------EEVGTVIAQADSA-------VDKDGN--LTEEFVSVRHQ 648
Cdd:PRK08565  503 VYLNGRligyHPDGEELAEKIrelrrsgkisdevnvayietGEINEVYVNCDSGrvrrpliVVENGKpkLTREHVEKLKK 582
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  649 GEF-----VRM------------------PPEKV----THMDVSAQQVVSVAASLIPFLEHDDANRALMGSNMQRQA--V 699
Cdd:PRK08565  583 GELtfddlVKMgvieyldaeeeenayvalDPEDLtpehTHLEIWPPAILGITASIIPYPEHNQSPRNTYQAAMAKQSlgL 662
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  700 PT----LRAD----------KPLVGT-GMEanvardsgvcvianrggaieyvdasrivirvnedemiageagvdiynLIK 764
Cdd:PRK08565  663 YAanfrIRTDtrghllhypqRPLVQTrALE-----------------------------------------------IIG 695
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  765 YTrsnqntcinqniivnlgdkvargdilaDGPStdmgelalGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQE 844
Cdd:PRK08565  696 YN---------------------------DRPA--------GQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRT 740
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  845 LSCVARDTKLGAE-EITADIPNV----GEAALSKLDESGIVYIGAEVTAGDILVGKVTPKgetQLTPEEKLLRAIFGEKa 919
Cdd:PRK08565  741 YETEERKYPGGQEdKIEIPEPNVrgyrGEEYYRKLDEDGIVSPEVEVKGGDVLIGKTSPP---RFLEELEELSLGLQER- 816
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  920 advKDSSLRVPSGTKGtVIDVQVFTrdglekddralaiekaqldayrkdlkeeykifeeaarervirllkgqESNGGGst 999
Cdd:PRK08565  817 ---RDTSVTVRHGEKG-IVDTVLIT-----------------------------------------------ESPEGN-- 843
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1000 krgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekfaekkrklatgdelttgvlKVVKVYLAVKR 1079
Cdd:PRK08565  844 ---------------------------------------------------------------------KLVKVRVRDLR 854
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1080 RIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILEThlgMAAKglgdkiekmlkeqrtv 1159
Cdd:PRK08565  855 IPELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLES---IAGK---------------- 915
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1160 lelrefldkiynkvggeqedldsltdaeVLALSGNLRAGVPlatpvFDGAEESQIKDLLELAGISRTGQTVLFDGRTGEQ 1239
Cdd:PRK08565  916 ----------------------------VAALEGRFVDATP-----FYGEPEEELRKELLKLGYKPDGTEVMYDGRTGEK 962
                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1240 FDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDdveg 1319
Cdd:PRK08565  963 IKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTEGRAREGGLRFGEMERDCLIGHGAAMLLKERLLDSSD---- 1038
                        1450      1460      1470      1480      1490      1500
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488043460 1320 RTRIY--------------KNIVDGNHYMDPG------MPESFNVLTKEIRSLGINIELKNGD 1362
Cdd:PRK08565 1039 KTTIYvcelcghiawydrrKNKYVCPIHGDKGnispveVSYAFKLLLQELMSMGISPRLKLGD 1101
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
26-509 3.61e-73

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 249.60  E-value: 3.61e-73
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460    26 YLLSIQVDSYRTFLQDgkTPKnrEDIGLQAAFRSVFPIESYSGNAA---LEFVEYSLGKPEFDVR----------ECILR 92
Cdd:pfam04563    1 GLVRQQLDSFNEFVDN--DLQ--KIIDENALIESEFEIQHPGENGDklsLKFGQIRLGKPMFDETdgstreiypqECRLR 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460    93 GSTYAAPMRVKIRLIIKDREtksikDVREQEVYMGEIPLMTEN------------------------GTFVINGTERVIV 148
Cdd:pfam04563   77 NLTYSAPLYVDLELSVYNGE-----DIKPIEVFIGRLPIMLRSnacilsgateselvklgecpldpgGYFIINGSEKVIV 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   149 SQLHRS---PGVFFDHDKGKTHSSGKVLYSARI--IPYRGSWLDF-EFDAKDLVYVRIDRRRKLL-ATVVLRALGYNNEQ 221
Cdd:pfam04563  152 AQEHRSrnhPIVFKKADPKKRGSVASVRSSAEIsvRPDSTSWVNVlEYLSNGTIYFKFPYIKKEIpIVIILRALGFTSDR 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   222 ILnlfYEKVPVYLDMGSYQIDLVPErlrgemaqfdiadndgkviVEQGKRINArhvrqmeaaglTKLSVPDEYLYERITA 301
Cdd:pfam04563  232 EI---FELICYDVNDQQLQEELLPS-------------------LEEGFKIRI-----------QTQEQALDYIGGRGRA 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   302 enitlrdgeviaantllshevmvklaeggvkqfnilftndidrgsfvadtlradttagreealveIYKVMRPGEPPTKEA 381
Cdd:pfam04563  279 -----------------------------------------------------------------IFRMGRPREPRIKYA 293
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   382 AENLFNNLFFSSERYDLSPVGRMKFnrrlgrpyevgtdqksrevegilshedIIDVLRTLVEIRNGKGEVDDIDHLGNRR 461
Cdd:pfam04563  294 EEILQKEVLPHLGTYELDETKKAYF---------------------------IGYMIRRLLLLALGRREVDDRDHLGNKR 346
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 488043460   462 VRSVGEMTENQFRVGLVRVERAVKERL--SQAETDNLSPQDLINAKPVAA 509
Cdd:pfam04563  347 LRLAGPLLASLFRVLFKKLVRDVRERLqkVLGSPDDLMLQLLVNAKPITS 396
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
611-1362 3.73e-57

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 209.50  E-value: 3.73e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   611 AVEYLSAIEEVGTVIAQADSavdkdgNLTEEFvsvrhqgefvrmppekvTHMDVSAQQVVSVAASLIPFLEHDDANRALM 690
Cdd:TIGR03670   91 VIEYLDAEEEENAYIALDPE------ELTPEH-----------------THLEIDPSAILGIIASTIPYPEHNQSPRNTM 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   691 GSNMQRQAVPTLRADKPLvgtgmeanvaR-DSgvcvianRGGAIEYVDASRIVIRVNEdemiageagvdiynLIKYTrsn 769
Cdd:TIGR03670  148 GAAMAKQSLGLYAANYRI----------RlDT-------RGHLLHYPQKPLVKTRVLE--------------LIGYD--- 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   770 qntcinqniivnlgdkvargdilaDGPStdmgelalGQNMRVAFMTWNGYNYEDSILLSERVLQEDRLTSIHIQELSCVA 849
Cdd:TIGR03670  194 ------------------------DRPA--------GQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAEE 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   850 RDTKLGAE-EITADIPNV----GEAALSKLDESGIVYIGAEVTAGDILVGKVTPkgetqltP---EEkllRAIFGEKAAD 921
Cdd:TIGR03670  242 RRYPGGQEdRFEIPEPDVrgyrGEEAYKHLDEDGIVYPEVEVKGGDVLIGKTSP-------PrflEE---LREFGLVTER 311
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   922 VKDSSLRVPSGTKGTVidvqvftrdglekddralaiekaqldayrkdlkeeykifeeaarERVIrLLKGQESNgggstkr 1001
Cdd:TIGR03670  312 RRDTSVTVRHGEKGIV--------------------------------------------DKVI-ITETEEGN------- 339
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1002 gdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekfaekkrklatgdelttgvlKVVKVYLAVKRRI 1081
Cdd:TIGR03670  340 -------------------------------------------------------------------KLVKVRVRDLRIP 352
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1082 QPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILEThlgmaakglgdkiekmlkeqrtvle 1161
Cdd:TIGR03670  353 ELGDKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLEM------------------------- 407
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1162 lrefldkIYNKVGgeqedldsltdaevlALSGNLRAGVPlatpvFDGAEESQIKDLLELAGISRTGQTVLFDGRTGEQFD 1241
Cdd:TIGR03670  408 -------IAGKVA---------------ALEGRRVDGTP-----FEGEPEEELRKELLKLGFKPDGKEVMYDGITGEKLE 460
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1242 RPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVE--- 1318
Cdd:TIGR03670  461 AEIFIGVIYYQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKYVvyv 540
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 488043460  1319 -----------GRTRIYKNIVDGN----HYMDpgMPESFNVLTKEIRSLGINIELKNGD 1362
Cdd:TIGR03670  541 cencghiawedKRKGTAYCPVCGEtgdiSPVE--MSYAFKLLLDELKSLGISPRLELGD 597
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
612-1362 7.07e-51

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 190.94  E-value: 7.07e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  612 VEYLSAIEEVGTVIAqadsaVDKDgNLTEEfvsvrHqgefvrmppekvTHMDVSAQQVVSVAASLIPFLEHDDANRALMG 691
Cdd:PRK07225   98 IEYLDAEEEENAYIA-----VYEE-DLTEE-----H------------THLEIDPSLILGIGAGMIPYPEHNASPRITMG 154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  692 SNMQRQA--VPT----LRADkplvgtgmeanvardsgvcviaNRGGAIEYVDASRIVIRVNEdemiageagvdiynLIKY 765
Cdd:PRK07225  155 AGMIKQSlgLPAanykLRPD----------------------TRGHLLHYPQVPLVKTQTQE--------------IIGF 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  766 TrsnqntcinqniivnlgdkvargdilaDGPStdmgelalGQNMRVAFMTWNGYNYEDSILLS----ERVL--------- 832
Cdd:PRK07225  199 D---------------------------ERPA--------GQNFVVAVMSYEGYNIEDALIMNkasiERGLgrshffrty 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  833 ----------QEDRLTsIHIQELScvardtklGAEeitadipnvGEAALSKLDESGIVYIGAEVTAGDILVGKVTP---- 898
Cdd:PRK07225  244 egeerrypggQEDRFE-IPDKDVR--------GYR---------GEEAYRHLDEDGLVNPETEVKEGDVLIGKTSPprfl 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  899 --KGETQLTPEEKllraifgekaadvKDSSLRVPSGTKGTVidvqvftrdglekddralaiekaqlDAyrkdlkeeykif 976
Cdd:PRK07225  306 eePDDFGISPEKR-------------RETSVTMRSGEEGIV-------------------------DT------------ 335
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  977 eeaarerVIrLLKGQESNgggstkrgdklveevlsglelvdlleiqpadeaiaerltqiqvflkeksaeidekfaekkrk 1056
Cdd:PRK07225  336 -------VI-LTETEEGS-------------------------------------------------------------- 345
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1057 latgdelttgvlKVVKVYLAVKRRIQPGDKMAGRHGNKGVVSNILPVEDMPHDANGVPVDIVLNPLGVPSRMNVGQILET 1136
Cdd:PRK07225  346 ------------RLVKVRVRDLRIPELGDKFASRHGQKGVIGLIVPQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLEM 413
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1137 hlgmaakglgdkiekmlkeqrtvlelrefldkIYNKVGgeqedldsltdaevlALSGNLRAGVPlatpvFDGAEESQIKD 1216
Cdd:PRK07225  414 --------------------------------IGGKVG---------------SLEGRRVDGTA-----FSGEDEEDLRE 441
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1217 LLELAGISRTGQTVLFDGRTGEQFDRPVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWA 1296
Cdd:PRK07225  442 ALEKLGFEHTGKEVMYDGITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDV 521
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460 1297 LEAYGAAYTLQEMLTVKSDDVE-------GRTRIY---KNIV------DGNHYMDPGMPESFNVLTKEIRSLGINIELKN 1360
Cdd:PRK07225  522 LIGHGAAMLLKERLLDESDKVEiyvcakcGMIAIYdkkRNRKycpicgEETDIYPVEMSYAFKLLLDELKSLGIAPRLEL 601

                  ..
gi 488043460 1361 GD 1362
Cdd:PRK07225  602 ED 603
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
522-589 5.26e-35

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 127.64  E-value: 5.26e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488043460   522 QFMDQNNPLSEITHKRRVSAlGPGGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAK 589
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYAR 67
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
1285-1359 8.80e-32

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 119.23  E-value: 8.80e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  1285 GGQRFGEMEVWALEAYGAAYTLQEMLTVKSD----DVEGRTRIYKN-----IVDGNHYMDPG-MPESFNVLTKEIRSLGI 1354
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAAynkcpICKGETDISPGyIPESFKLLFQELQSLGI 80

                   ....*
gi 488043460  1355 NIELK 1359
Cdd:pfam04560   81 DPRLL 85
RNA_pol_Rpb2_45 pfam10385
RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent ...
600-665 3.93e-29

RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region.


Pssm-ID: 463067 [Multi-domain]  Cd Length: 66  Bit Score: 110.92  E-value: 3.93e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488043460   600 YRKVVDGRVTDAVEYLSAIEEVGTVIAQADSAVDKDGNLTEEFVSVRHQGEFVRMPPEKVTHMDVS 665
Cdd:pfam10385    1 YRKVEDGKVTDEIVYLTADEEDGYVIAQANAPLDEDGRFVDERVSARYRGEFPLVPPEEVDYMDVS 66
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
439-589 1.77e-22

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 102.72  E-value: 1.77e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  439 RTLVEIRNGKGEVDDIDHLGNRRVRSVGEMTENQFRVGLVRVERAVKERLSQAETDN--LSPQDLINAKPVAAAIKEFF- 515
Cdd:PRK09606  315 EACFELALGRREEDDKDHYANKRLKLAGDLMEDLFRVAFNRLARDVKYQLERANMRNreLSIKTAVRSDVLTERLEHAMa 394
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460  516 ------GSSQLSQFMDQNNPLSEITHKRRVSAlgpgGLTRERAGFEVRDVHQTHYGRVCPIETPEGPNIGLINSLSVYAK 589
Cdd:PRK09606  395 tgnwvgGRTGVSQLLDRTDYMATLSHLRRVVS----PLSRSQPHFEARDLHPTQWGRICPSETPEGPNCGLVKNFAQMVE 470
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
153-463 3.89e-10

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 60.44  E-value: 3.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   153 RSPGVFF--DHDKGKTHSSgkvlYSARIIPYRGSWLDFEFDAKDLVYVRIDRRRKLLATVVLRALG-YNNEQILNLFyek 229
Cdd:pfam04561    1 RSNGIYVekELDKNGIIAT----YTSSLISNRGSWLKLEIDGKTLIWSRPSKKRKIPIVIFLKALGlVSDREILDRL--- 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   230 vpVYLDMGSYQIDLVPERLrgemaqfdiadndgkvivEQgkrinarhvrqmeaagltklsvpdeylyeritAENITlrdg 309
Cdd:pfam04561   74 --CYDFNDPQMLELLKPEL------------------EE--------------------------------AENIY---- 97
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488043460   310 eviaantllshevmvklaeggvkqfnilftndidrgsfvadtlradttaGREEALVEIYKV--MRPGEPPTKEAAENLFN 387
Cdd:pfam04561   98 -------------------------------------------------TQEEALDYIGKGfaLRRGEEPRLQRAREILY 128
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488043460   388 NLFfsserydlspvGRMKFNRRLGRpyEVGTDQKsrevegILSHEDIIDVLRTLVEIRNGKGEVDDIDHLGNRRVR 463
Cdd:pfam04561  129 SRD-----------PKYNLNKHLGL--NEPFENE------RLKAQDILYMIDRLLNLKLGRRKPDDIDHLGNKRVR 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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