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Conserved domains on  [gi|488044821|ref|WP_002116218|]
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MULTISPECIES: malonic semialdehyde reductase [Acinetobacter]

Protein Classification

nitroreductase family protein( domain architecture ID 10012358)

nitroreductase family protein, similar to nitroreductase which catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles by using NAD(P)H as electron donor in an obligatory two-electron transfer and FMN as cofactor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 9-194 2.05e-124

malonic semialdehyde reductase; Provisional


:

Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 348.73  E-value: 2.05e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   9 LDQLFLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTAPVTVLVAT 88
Cdd:PRK05365   9 LDQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSEGNLAKTLAAPVTAIVAY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  89 DAKFYDKLPELFPYADAKSWFTSSEAEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLI 168
Cdd:PRK05365  89 DTEFHEHLPKLFPHADARSWFAGNPALAEETAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAGTTWKSNFL 168

                        170       180
                 ....*....|....*....|....*.
gi 488044821 169 INIGYGDPQKVYTRLPRLNFEEACRV 194
Cdd:PRK05365 169 VNIGYGDPAKLFPRLPRLSFDEACRI 194
 
Name Accession Description Interval E-value
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 9-194 2.05e-124

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 348.73  E-value: 2.05e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   9 LDQLFLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTAPVTVLVAT 88
Cdd:PRK05365   9 LDQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSEGNLAKTLAAPVTAIVAY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  89 DAKFYDKLPELFPYADAKSWFTSSEAEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLI 168
Cdd:PRK05365  89 DTEFHEHLPKLFPHADARSWFAGNPALAEETAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAGTTWKSNFL 168

                        170       180
                 ....*....|....*....|....*.
gi 488044821 169 INIGYGDPQKVYTRLPRLNFEEACRV 194
Cdd:PRK05365 169 VNIGYGDPAKLFPRLPRLSFDEACRI 194
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 9-192 8.66e-111

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 314.19  E-value: 8.66e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   9 LDQLFLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTAPVTVLVAT 88
Cdd:cd02148    2 LDQLFTEARTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPHLSEGNREKTMAAPVTAILAY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  89 DAKFYDKLPELFPYADAKSWFTSSEAE-AHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINL 167
Cdd:cd02148   82 DTEFYEHLPRLFPHGDARSWFFGSGPArAEETAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAGTRWKSNL 161

                        170       180
                 ....*....|....*....|....*
gi 488044821 168 IINIGYGDPQKVYTRLPRLNFEEAC 192
Cdd:cd02148  162 VVNLGYGDPSKLFPRLPRLDFDEAC 186
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 9-192 2.49e-45

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 147.31  E-value: 2.49e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   9 LDQLFLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTAPVTVLVAT 88
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALAEANQEWVADAPVLIVVCA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  89 DAKFYDKLPElfpyadakswftsseaeahETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLI 168
Cdd:COG0778   81 DPDRSEKVPE-------------------RYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEKVRELLGLPEGEEPVAL 141

                        170       180
                 ....*....|....*....|....
gi 488044821 169 INIGYGDPQKvyTRLPRLNFEEAC 192
Cdd:COG0778  142 LALGYPAEEL--NPRPRKPLEEVV 163
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 17-173 2.32e-21

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 85.91  E-value: 2.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   17 RTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTA---PVTVLVATDAKFY 93
Cdd:pfam00881   5 RSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAAlllLLRRDANLKLLLQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   94 DKLPE----LFPYADAKSWFTSSEAEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLII 169
Cdd:pfam00881  85 DFLRGapvlIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELLGLPDDERLVGLI 164


                  ....
gi 488044821  170 NIGY 173
Cdd:pfam00881 165 AVGY 168
 
Name Accession Description Interval E-value
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 9-194 2.05e-124

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 348.73  E-value: 2.05e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   9 LDQLFLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTAPVTVLVAT 88
Cdd:PRK05365   9 LDQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSEGNLAKTLAAPVTAIVAY 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  89 DAKFYDKLPELFPYADAKSWFTSSEAEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLI 168
Cdd:PRK05365  89 DTEFHEHLPKLFPHADARSWFAGNPALAEETAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAGTTWKSNFL 168

                        170       180
                 ....*....|....*....|....*.
gi 488044821 169 INIGYGDPQKVYTRLPRLNFEEACRV 194
Cdd:PRK05365 169 VNIGYGDPAKLFPRLPRLSFDEACRI 194
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 9-192 8.66e-111

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 314.19  E-value: 8.66e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   9 LDQLFLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTAPVTVLVAT 88
Cdd:cd02148    2 LDQLFTEARTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPHLSEGNREKTMAAPVTAILAY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  89 DAKFYDKLPELFPYADAKSWFTSSEAE-AHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINL 167
Cdd:cd02148   82 DTEFYEHLPRLFPHGDARSWFFGSGPArAEETAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAGTRWKSNL 161

                        170       180
                 ....*....|....*....|....*
gi 488044821 168 IINIGYGDPQKVYTRLPRLNFEEAC 192
Cdd:cd02148  162 VVNLGYGDPSKLFPRLPRLDFDEAC 186
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 9-192 2.49e-45

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 147.31  E-value: 2.49e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   9 LDQLFLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTAPVTVLVAT 88
Cdd:COG0778    1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALAEANQEWVADAPVLIVVCA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  89 DAKFYDKLPElfpyadakswftsseaeahETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLI 168
Cdd:COG0778   81 DPDRSEKVPE-------------------RYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEKVRELLGLPEGEEPVAL 141

                        170       180
                 ....*....|....*....|....
gi 488044821 169 INIGYGDPQKvyTRLPRLNFEEAC 192
Cdd:COG0778  142 LALGYPAEEL--NPRPRKPLEEVV 163
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 24-190 3.96e-23

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 89.99  E-value: 3.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  24 DKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPAlsSGNVEKTMTAPVTVLVATDakfydklpelfpya 103
Cdd:cd02137   16 DHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEA--AYNQPQVTTASAVILVLGD-------------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821 104 dakswftsseaeahetafRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLIINIGYgdPQKVYTRL 183
Cdd:cd02137   80 ------------------LNAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAELLNLPDRYVPVLLIAIGK--AADKAPRS 139


                 ....*..
gi 488044821 184 PRLNFEE 190
Cdd:cd02137  140 GRLPVDE 146
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 17-173 2.32e-21

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 85.91  E-value: 2.32e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   17 RTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKTMTA---PVTVLVATDAKFY 93
Cdd:pfam00881   5 RSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALELLLVEPAAAlllLLRRDANLKLLLQ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821   94 DKLPE----LFPYADAKSWFTSSEAEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLII 169
Cdd:pfam00881  85 DFLRGapvlIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELLGLPDDERLVGLI 164


                  ....
gi 488044821  170 NIGY 173
Cdd:pfam00881 165 AVGY 168
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 21-175 2.10e-19

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 81.21  E-value: 2.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  21 TWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPAlsSGNVEKTMTAPVTVLVATDAKfyDKLPEL- 99
Cdd:cd03370   13 KYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAA--AYGQAQVTSAPAVIVIYSDME--DALANLe 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821 100 ------FPyADAKSWFTS---------SEAEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHH 164
Cdd:cd03370   89 etihpgLS-EERRQREAAglrgafgkmSVEQRGQWGLAQANIALGFLLLAAQSLGYDTSPMLGFDPEKVKALLGLPEHVT 167

                        170
                 ....*....|.
gi 488044821 165 INLIINIGYGD 175
Cdd:cd03370  168 IAALVALGKPA 178
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 13-173 2.53e-18

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 77.34  E-value: 2.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  13 FLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNvEKTMTAPVTVLVATDakf 92
Cdd:cd02062    1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAAPNQ-KFIAGAPVVIVVVAD--- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  93 ydklpelfpyadakswftssEAEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFD--AKQVDELFFAGTNHHINLIIN 170
Cdd:cd02062   77 --------------------PDKSRPWALEDAGAAAQNLLLAAAALGLGSCWIGGFDfrEDKVRELLGIPENLRPVALIA 136


                 ...
gi 488044821 171 IGY 173
Cdd:cd02062  137 IGY 139
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 25-173 3.71e-18

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 77.29  E-value: 3.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  25 KAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPAlSSGNVEKTMTAPVTVLVATDakfydklpelfpyad 104
Cdd:cd02149   19 KKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPA-AWFNQPQIKDASHVVVFLAK--------------- 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821 105 aKSWftsSEAEAHetafrnssLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTN-HHINLIINIGY 173
Cdd:cd02149   83 -KDW---SAKQTY--------IALGNMLLAAAMLGIDSCPIEGFDPAKLDEILGLDEKgYKISVMVAFGY 140
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
25-157 9.11e-12

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 61.53  E-value: 9.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  25 KAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSG---NVEKTMTAPVTVLVATDAKFYDK-LPELF 100
Cdd:PRK11053  20 KKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEGKARIAKAAAGNyafNERKILDASHVVVFCAKTDMDDAyLELVL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488044821 101 PYADAKSWFTSSEAEA------------HETAFRNSS--------LQAAYLIMACRSLGLDTGPMSGFDAKQVDELF 157
Cdd:PRK11053 100 EQEDADGRFATEEAKAaqdkgrrffadmHRKELKDLQhwmekqvyLALGNLLLGAAALGIDATPIEGFDAAILDAEF 176
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 24-176 4.74e-11

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 58.71  E-value: 4.74e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  24 DKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTP-EAKQKLKPALSSGNVEKTMTAPVTVLVATDaKFYDKLPELFPY 102
Cdd:cd02138   13 PEPISEEDLLSLFEAARWAPSCFNEQPWRFVVARRDtEAFEKLLDLLAEGNQSWAKNAPVLIVVLAK-TEFDHNGKPNRY 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488044821 103 AdakswftsseaeAHET--AFRNSSLQAAylimacrSLGLDTGPMSGFDAKQVDELFFAGTNHHINLIINIGY-GDP 176
Cdd:cd02138   92 A------------LFDTgaAVANLALQAT-------ALGLVVHQMAGFDPEKAKEALGIPDEYEPITMIAIGYpGDP 149
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 24-173 2.24e-08

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 50.85  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  24 DKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPAlssgnVEKTMTAPVTVLVAtdakfYDKlpelfpya 103
Cdd:cd20609   17 DKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKA-----TPRFFGAPLVIVVC-----YDK-------- 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488044821 104 dAKSWFTSSEAeahetafRNSSLQ-----AAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLIINIGY 173
Cdd:cd20609   79 -DESWKRPYDG-------KDSGDIdaaivATHMMLAATELGLGTCWVGNFDPEKVREAFNLPENLEPVAILPLGY 145
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 19-190 7.83e-08

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 49.51  E-value: 7.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  19 HST--WLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTpEAKQKLKpalssgnvEKTMTAPVTVLVatdakFYDKL 96
Cdd:cd02136    6 RSVraFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTG-KARERLK--------KAFFGAPVALFL-----TMDKV 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  97 PELFPYADAkswftsseaeahetafrnsslqAAYL--IM-ACRSLGLDTGPMSGF--DAKQVDELFFAGTNHHINLIINI 171
Cdd:cd02136   72 LGPWSWFDL----------------------GAFLqnLMlAAHALGLGTCPQGALagYPDVVRKELGIPDDEELVCGIAL 129

                        170       180
                 ....*....|....*....|.
gi 488044821 172 GYGDPQKVYTRL--PRLNFEE 190
Cdd:cd02136  130 GYPDPDAPVNQFrtPREPLEE 150
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 23-173 5.13e-07

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 47.33  E-value: 5.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  23 LDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLkpALSSGNVEKTMT-APVTVLVATDAKfydklpelfp 101
Cdd:cd20608   14 SDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSEL--AKKESPSNGWLKdAPVIIVVCADPK---------- 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488044821 102 yadaKSWftssEAEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGFDAKQVDELFFAGTNHHINLIINIGY 173
Cdd:cd20608   82 ----DSG----WLNGQNYYLVDAAIAMQNLMLAATDLGLGTCWIGAFDEKKVKEILGIPENIRVVALTPLGY 145
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 22-178 1.26e-06

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 46.37  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  22 WLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGnveKTM--TAPVTVLVATDAkfydklpel 99
Cdd:cd02151   12 YTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSECKPHG---SAFlkGAPAAIVVLADT--------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821 100 fpyADAKSWftsseaeaHETAfrnsSLQAAYLIMACRSLGL-------DTGPMS-GFDAKQ-VDELFFAGTNHHINLIIN 170
Cdd:cd02151   80 ---EKSDTW--------IEDA----SIAATYIQLAAESLGLgscwiqiRNRETQdGKTAEEyVRELLGIPENYRVLCIIA 144


                 ....*...
gi 488044821 171 IGYGDPQK 178
Cdd:cd02151  145 LGYPDEEK 152
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 24-156 3.20e-05

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 42.46  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  24 DKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPAlsSGNVEKTMTAPVT-VLVATDAKFYDklpelfpy 102
Cdd:cd02139   16 PTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAEA--ANGQKFIAEAPVViVACADPSESGM-------- 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488044821 103 ADAKSWFTSSEAEAHEtafrnsslqaaYLIMACRSLGLDTGPMSGFDAKQVDEL 156
Cdd:cd02139   86 GCGKPYYLVDVAIAME-----------HLVLAATEEGLGTCWIGAFDEDKVKEI 128
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 11-185 1.62e-04

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 41.07  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  11 QLFLEARTHSTWLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPAlsSGNVEKTMTAPVTVLVATDA 90
Cdd:cd02146    3 ETILNHRSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAEL--AGNQPYVAQAPVFLVFCADL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  91 KFYDKLPELFPYADAKSWFTsseaEAHETAFRNSSLQAAYLIMACRSLGLDTGPMSGF--DAKQVDELF--------FAG 160
Cdd:cd02146   81 YRHQKIAEEAGGKDVGLDYL----ESFLVGVVDAALAAQNALVAAESLGLGIVYIGGIrnNPEEVIELLglpeyvfpLFG 156

                        170       180
                 ....*....|....*....|....*.
gi 488044821 161 tnhhinliINIGYGDPQ-KVYTRLPR 185
Cdd:cd02146  157 --------LTVGHPDPTpEVKPRLPL 174
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 22-91 7.09e-04

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 38.35  E-value: 7.09e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488044821  22 WLDKAVSPEQIQQIYDLVKMAPTSANCSPARFVFLTTPEAKQKLKPALSSGNVEKtmTAPVTVLVATDAK 91
Cdd:cd02150   10 YTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAEAHPYGKMLK--EAPLAIVVCGDPS 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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