|
Name |
Accession |
Description |
Interval |
E-value |
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
31-461 |
3.31e-109 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 330.72 E-value: 3.31e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 31 KIKPRSAAMRTTILVLLVVFFSLFMSLWFFWRTLYLPEIQQHARYLAVELELVNnPDIRIFHRENEVDIDAwlRNRV--- 107
Cdd:PRK09467 2 RFSPRSSFARTLLLIVTLLFISQVVSYLVVLNYAILPSLQQFNKVLAYEVRLLF-TDQLEDGTQLVVPPAF--RREIyre 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 108 -GIEYVTNPKEYPS-VREKVIAEFFTNHVEKKLAneiGTKDVTVYfQFKPSPRIWIQTPEMHGNWVREPLKTY--ANYSP 183
Cdd:PRK09467 79 lGISLYSNEAAEEAgLRWAQHYEFLSEQMSQQLG---GPTEVRVE-VGKESPIVWIKTPLAPNIWVRVPLTEIhqGDFSP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 184 ---ELLV--------GWVVgvpllsaiiililVRQMNRPLRRLQNAANEYSKSGTAPYLDTNhGPLEIRQVNQAFNRMVY 252
Cdd:PRK09467 155 lfrYTLAigllsvagGWLF-------------IRIQNRPLVALEHAALQVGKGEIPPPLREY-GASEVRSVTRAFNQMAA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 253 TLDQTERERRIMLAGISHDLRTPLTRIRLTAEMLP--DEFLREGLVYDVDDMDAILNQFISYMRDGSDEELKDTNINMLL 330
Cdd:PRK09467 221 GIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSeeDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 331 QElVVQFKP---LDIQFEMQDVPI-IPARSLSLKRLIANLINNAKRYGAEPIELSAKVENESILITVADHGEGIPADQIE 406
Cdd:PRK09467 301 GE-VIAAESgyeREIETALQPGPIeVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLK 379
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 488045638 407 ELMQPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIP 461
Cdd:PRK09467 380 HLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
246-463 |
5.77e-55 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 183.95 E-value: 5.77e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 246 AFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAEML------PDEFLREGL---VYDVDDMDAILNQFISYMRDG 316
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLldeedlSPEERRELLeiiRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 317 SDE---ELKDTNINMLLQELVVQFKPL----DIQFEMQ---DVPIIPARSLSLKRLIANLINNAKRYGAE--PIELSAKV 384
Cdd:COG2205 81 SGKlslELEPVDLAELLEEAVEELRPLaeekGIRLELDlppELPLVYADPELLEQVLANLLDNAIKYSPPggTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488045638 385 ENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPKP 463
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
237-461 |
4.61e-53 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 181.64 E-value: 4.61e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 237 PLEIRQVNQAFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAEML---PDEFLREGL---VYDVDDMDAILNQFI 310
Cdd:COG0642 86 LLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLleeLDEEQREYLetiLRSADRLLRLINDLL 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 311 SYMRDGS---DEELKDTNINMLLQELVVQFKPL----DIQFEMQ---DVPIIPARSLSLKRLIANLINNAKRYGAE--PI 378
Cdd:COG0642 166 DLSRLEAgklELEPEPVDLAELLEEVVELFRPLaeekGIELELDlpdDLPTVRGDPDRLRQVLLNLLSNAIKYTPEggTV 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 379 ELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISL 458
Cdd:COG0642 246 TVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTL 325
|
...
gi 488045638 459 PIP 461
Cdd:COG0642 326 PLA 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
238-463 |
1.38e-49 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 174.36 E-value: 1.38e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 238 LEIRQVNQAFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAEML------PDEFLREGL--VYD-VDDMDAILNQ 308
Cdd:COG5002 142 LLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLldgaadDPEERREYLeiILEeAERLSRLVND 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 309 FISYMRDGSDE---ELKDTNINMLLQELVVQFKPL----DIQFEMQ---DVPIIPARSLSLKRLIANLINNAKRYGAE-- 376
Cdd:COG5002 222 LLDLSRLESGElklEKEPVDLAELLEEVVEELRPLaeekGIELELDlpeDPLLVLGDPDRLEQVLTNLLDNAIKYTPEgg 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 377 PIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSART--IQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEV 454
Cdd:COG5002 302 TITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSreTGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTF 381
|
....*....
gi 488045638 455 IISLPIPKP 463
Cdd:COG5002 382 TITLPLARE 390
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
264-464 |
6.80e-38 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 143.18 E-value: 6.80e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 264 MLAGISHDLRTPLTRIRLTAEML----------PDEFLREGL---VYDVDDMDAILNQFISYMRdGSDEELKDTNINMLL 330
Cdd:COG5000 204 LARRIAHEIKNPLTPIQLSAERLrrkladkleeDREDLERALdtiIRQVDRLKRIVDEFLDFAR-LPEPQLEPVDLNELL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 331 QELVVQFKPL----DIQFEMQ---DVPIIPARSLSLKRLIANLINNAKRYGAEP--IELSAKVENESILITVADHGEGIP 401
Cdd:COG5000 283 REVLALYEPAlkekDIRLELDldpDLPEVLADRDQLEQVLINLLKNAIEAIEEGgeIEVSTRREDGRVRIEVSDNGPGIP 362
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488045638 402 ADQIEELMQPFVrgdSARTiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPKPS 464
Cdd:COG5000 363 EEVLERIFEPFF---TTKP-KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAEEA 421
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
210-460 |
9.79e-36 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 138.14 E-value: 9.79e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 210 RPLRRLQNAANEYSKSGTAPYLDTNHGPLEIRQVNQAFNRMVYTLDQ-TERERRiMLAGISHDLRTPLTRIRL-TAemlp 287
Cdd:PRK09470 192 KPARKLKNAADEVAQGNLRQHPELETGPQEFRQAGASFNQMVTALERmMTSQQR-LLSDISHELRTPLTRLQLaTA---- 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 288 deFLREglvydvddmdailnqfisymRDGSDEELK---------DTNINMLLQ--------ELVVQFKPL---------D 341
Cdd:PRK09470 267 --LLRR--------------------RQGESKELErieteaqrlDSMINDLLVlsrnqqknHLERETFKAnslwsevleD 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 342 IQFEMQ------DVPIIPARSL------SLKRLIANLINNAKRYGAEPIELSAKVENESILITVADHGEGIPADQIEELM 409
Cdd:PRK09470 325 AKFEAEqmgkslTVSAPPGPWPingnpnALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIF 404
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 488045638 410 QPFVRGDSARTIQ--GSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPI 460
Cdd:PRK09470 405 RPFYRVDEARDREsgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPL 457
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
1.14e-35 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 127.95 E-value: 1.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEPIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVDIH 438
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDAH 80
|
90 100
....*....|....*....|.
gi 488045638 439 HGEIQIHNREQGGLEVIISLP 459
Cdd:cd16950 81 GGSLTLANRAGGGLCARIELP 101
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
359-458 |
4.35e-33 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 120.79 E-value: 4.35e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAE--PIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVD 436
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPggTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|..
gi 488045638 437 IHHGEIQIHNREQGGLEVIISL 458
Cdd:cd00075 81 AHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
359-461 |
1.11e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 114.67 E-value: 1.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAE--PIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGD-SARTIQGSGLGLAIVKRIV 435
Cdd:smart00387 6 LRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDkRSRKIGGTGLGLSIVKKLV 85
|
90 100
....*....|....*....|....*.
gi 488045638 436 DIHHGEIQIHNREQGGLEVIISLPIP 461
Cdd:smart00387 86 ELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
264-460 |
2.98e-30 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 120.67 E-value: 2.98e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 264 MLAGISHDLRTPLTRIRLTAEML----PDEFLREGLVYDVDDMD-------AILNQFISYMRdGSDEELKDTNINMLLQE 332
Cdd:COG4191 145 LAAGIAHEINNPLAAILGNAELLrrrlEDEPDPEELREALERILegaeraaEIVRSLRAFSR-RDEEEREPVDLNELIDE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 333 LVV----QFKPLDIQFEMQ---DVPIIPARSLSLKRLIANLINNAK---RYGAEP-IELSAKVENESILITVADHGEGIP 401
Cdd:COG4191 224 ALEllrpRLKARGIEVELDlppDLPPVLGDPGQLEQVLLNLLINAIdamEEGEGGrITISTRREGDYVVISVRDNGPGIP 303
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488045638 402 ADQIEELMQPFV----RGdsartiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPI 460
Cdd:COG4191 304 PEVLERIFEPFFttkpVG------KGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
19-463 |
8.65e-30 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 121.82 E-value: 8.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 19 ERKRTRWERFLDKIKPRSAAMRTTILVLLVVFFSLFMSLWFFWRTLYLPEIQQHARYLAVELELVNNPDIRIFHRENEVD 98
Cdd:COG4251 55 LLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLAL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 99 IDAWLRNRVGIEYVTNPKEYPSVREKVIAEFFTNHVEKKLANEIGTKDVTVYFQFKPSPRIWIQTPEMHGNWVREPLKTY 178
Cdd:COG4251 135 LLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLE 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 179 ANYSPELLVGWVVGVPLLSAIIILILVRQMNRPLRRLQNAANEYsksgtapyldtnhgpLEIRQVNQAFNRMVYTLDQTE 258
Cdd:COG4251 215 AELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELR---------------LELEELEEELEERTAELERSN 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 259 RERRIMLAGISHDLRTPLTRIRLTAEMLPDEFlreglvydVDDMDAILNQFISYMRDGS-------------------DE 319
Cdd:COG4251 280 EELEQFAYVASHDLREPLRKISGFSQLLEEDY--------GDKLDEEGREYLERIRDAAermqaliddllaysrvgrqEL 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 320 ELKDTNINMLLQELVVQFKPL----DIQFEMQDVPIIPARSLSLKRLIANLINNAKRY---GAEP-IELSAKVENESILI 391
Cdd:COG4251 352 EFEPVDLNELLEEVLEDLEPRieerGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYsrpGEPPrIEIGAEREGGEWVF 431
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488045638 392 TVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPKP 463
Cdd:COG4251 432 SVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
246-461 |
1.22e-29 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 120.48 E-value: 1.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 246 AFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAEML--PDEFLREGLVYDVDDMDAILNQFISYMR-DGSDEELK 322
Cdd:PRK10604 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSdnLSAAESQALNRDIGQLEALIEELLTYARlDRPQNELH 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 323 DTNINML--LQELVVQFKPL--DIQFEMQdvpiIPARSLS-------LKRLIANLINNAKRYGAEPIELSAKVENESILI 391
Cdd:PRK10604 277 LSEPDLPawLSTHLADIQAVtpEKTVRLD----TPHQGDYgaldmrlMERVLDNLLNNALRYAHSRVRVSLLLDGNQACL 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488045638 392 TVADHGEGIPADQIEELMQPFVRGDSA--RTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIP 461
Cdd:PRK10604 353 IVEDDGPGIPPEERERVFEPFVRLDPSrdRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVW 424
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
205-459 |
3.22e-29 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 117.76 E-value: 3.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 205 VRQMNRPLRRLQNAANEYSKSGTAPyLDTNHGPLEIRQVNQAFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAE 284
Cdd:PRK10755 82 VRWITRPLAELQKELEARTADNLTP-IAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLE 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 285 MLPDEFLREG--LVYDVDDMDAILNQFISYMRDGSD------------EELKDTNINMLLQELVVQFKPLDIQfEMQDVP 350
Cdd:PRK10755 161 LLEKQHHIDVapLIARLDQMMHTVEQLLQLARAGQSfssghyqtvkllEDVILPSQDELSEMLEQRQQTLLLP-ESAADI 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 351 IIPARSLSLKRLIANLINNAKRYGAE--PIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSarTIQGSGLGL 428
Cdd:PRK10755 240 TVQGDATLLRLLLRNLVENAHRYSPEgsTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDS--RYGGIGLGL 317
|
250 260 270
....*....|....*....|....*....|..
gi 488045638 429 AIVKRIVDIHHGEIQIHNR-EQGGLEVIISLP 459
Cdd:PRK10755 318 SIVSRITQLHHGQFFLQNRqERSGTRAWVWLP 349
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
206-459 |
4.91e-29 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 119.16 E-value: 4.91e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 206 RQMNRPLRRLQNAANEYSKSGTAPYLDTNHGPlEIRQVNQAFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAEM 285
Cdd:NF012163 186 RGLLAPVKRLVEATHRLAAGDYTTRVTPTSND-ELGKLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRAELEA 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 286 LPD---EFLREglvyDVDDMDAILNQFISYMRDGSDEELKDT----------NINMLLQELVVQFKP------LDIQFEM 346
Cdd:NF012163 265 IQDgirKFTPE----SLDSLQAEVGTLTKLVDDLHDLSMSDEgalayqkasvDLVPLLEVEGGAFRErfasagLELEVSL 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 347 QDVPIIPARSLSLKRLIANLINNAKRY--GAEPIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQ-- 422
Cdd:NF012163 341 PDSSLVFGDRDRLMQLFNNLLENSLRYtdSGGSLHISASQRPKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRAsg 420
|
250 260 270
....*....|....*....|....*....|....*..
gi 488045638 423 GSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:NF012163 421 GSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
256-463 |
6.25e-29 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 120.91 E-value: 6.25e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 256 QTERE--RRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREG-------------------LVYDVDDMDAILNQFISYMR 314
Cdd:PRK10490 657 ASEREqlRNALLAALSHDLRTPLTVLFGQAEILTLDLASEGspharqaseirqqvlnttrLVNNLLDMARIQSGGFNLRK 736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 315 D-GSDEELKDTNINMLlqELVVQFKPLDIQFEmQDVPIIPARSLSLKRLIANLINNAKRYGAE--PIELSAKVENESILI 391
Cdd:PRK10490 737 EwLTLEEVVGSALQML--EPGLSGHPINLSLP-EPLTLIHVDGPLFERVLINLLENAVKYAGAqaEIGIDAHVEGERLQL 813
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488045638 392 TVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPKP 463
Cdd:PRK10490 814 DVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETP 885
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
6.99e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 107.03 E-value: 6.99e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEPIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQ--GSGLGLAIVKRIVD 436
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDREsgGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|...
gi 488045638 437 IHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLP 103
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
255-467 |
1.65e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 110.32 E-value: 1.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 255 DQTERER--------------RIMLAGISHDLRTPLTRIRLTAEML----PDEFLRE--GLVYD-VDDMDAILNQFISYM 313
Cdd:COG3852 115 DITERKRlerelrraeklaavGELAAGLAHEIRNPLTGIRGAAQLLerelPDDELREytQLIIEeADRLNNLVDRLLSFS 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 314 RdGSDEELKDTNINMLLQELVVQFK---PLDIQFEMQ---DVPIIPARSLSLKRLIANLINNAKRYGAEP--IELSAKVE 385
Cdd:COG3852 195 R-PRPPEREPVNLHEVLERVLELLRaeaPKNIRIVRDydpSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGgtITIRTRVE 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 386 ----------NESILITVADHGEGIPADQIEELMQPFVrgdSARTiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVI 455
Cdd:COG3852 274 rqvtlgglrpRLYVRIEVIDNGPGIPEEILDRIFEPFF---TTKE-KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFR 349
|
250
....*....|..
gi 488045638 456 ISLPIPKPSTEE 467
Cdd:COG3852 350 IYLPLEQAEEEP 361
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
208-461 |
2.66e-25 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 108.39 E-value: 2.66e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 208 MNRPLRRLQNAANEYSKsGTAPYLDTNHGPlEIRQVNQAFNRMvytldqteRERrimLAG----------ISHDLRTPLT 277
Cdd:PRK11100 206 LNRSIRRLTRYADAVTE-GKPVPLPKLGSS-ELRELAQALESM--------RVK---LEGkayveqyvqtLTHELKSPLA 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 278 RIRLTAEMLPDEF---LREGLVYDVDDMDAILNQFISYMRDGSD-------EELKDTNINMLLQELVVQFKPL----DIQ 343
Cdd:PRK11100 273 AIRGAAELLQEDPppeDRARFTGNILTQSARLQQLIDRLLELARleqrqelEVLEPVALAALLEELVEAREAQaaakGIT 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 344 FEMQDVPI-IPARSLSLKRLIANLINNAKRY---GAEpIELSAKVENESILITVADHGEGIPADQIEELMQPF---VRGD 416
Cdd:PRK11100 353 LRLRPDDArVLGDPFLLRQALGNLLDNAIDFspeGGT-ITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFyslPRPA 431
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 488045638 417 SARtiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIP 461
Cdd:PRK11100 432 NGR--KSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
356-462 |
2.81e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 99.75 E-value: 2.81e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 356 SLSLKRLIANLINNAKRY--GAEPIELSAKVENEsILITVADHGEGIPADQIEELMQPFVRGDSaRTIQGSGLGLAIVKR 433
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHaaKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADK-RGGGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*....
gi 488045638 434 IVDIHHGEIQIHNREQGGLEVIISLPIPK 462
Cdd:pfam02518 81 LVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
205-443 |
1.04e-24 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 106.32 E-value: 1.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 205 VRQMNRPLRRLQNAANEYSKSGTAPYLDTNHGPLEIRQVNQAFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAE 284
Cdd:TIGR01386 185 TRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQ 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 285 ML-----PDEFLREGLVYDVDD---MDAILNQFISYMRdgSDE-----ELKDTNINMLLQELVVQFKPLdiqFEMQDVPI 351
Cdd:TIGR01386 265 VAlsqprTGEEYREVLESNLEElerLSRMVSDMLFLAR--ADNgqlalERVRLDLAAELAKVAEYFEPL---AEERGVRI 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 352 -------IPARSLSLKRLIANLINNAKRYGAEPIELSAKVENES--ILITVADHGEGIPADQIEELMQPFVRGDSART-- 420
Cdd:TIGR01386 340 rvegeglVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSdeVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSns 419
|
250 260
....*....|....*....|...
gi 488045638 421 IQGSGLGLAIVKRIVDIHHGEIQ 443
Cdd:TIGR01386 420 GEGTGLGLAIVRSIMEAHGGRAS 442
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
256-462 |
1.80e-24 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 105.60 E-value: 1.80e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 256 QTERERRI--MLAGISHDLRTPLTRIRLTAEML-------PDEFLREGLVYDVDDMDAILNQFISYMRDGsDEELKDTNI 326
Cdd:COG5808 234 NTQKLELIgtFAASTAHEIRNPLTSIKGFIQLLqekypelEDQKYFDIIQEEIQRINQIVSEFLVLGKPT-AKKLELDDL 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 327 NMLLQELVVQFKPL----DIQFEMQ--DVPI-IPARSLSLKRLIANLINNAKRYGAE--PIELSAKVENESILITVADHG 397
Cdd:COG5808 313 NELIEEILSIIDSEanlkNIRVEKQslDEPLhIKCDKDRIKQVLLNLIKNAIEAMKEggKLTISIENDDEKAVIEVIDNG 392
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488045638 398 EGIPADQIEELMQPFVrgdsARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPK 462
Cdd:COG5808 393 EGIPEDIIDEIFEPFV----TTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPLKK 453
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
186-457 |
3.18e-24 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 104.73 E-value: 3.18e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 186 LVGWVVGVPLLSAIIILILVRQMnRPLRRLQNAANEYSKSGTAPyLDTNHGPLEIRQV----NQAFNRmvyTLDQTERER 261
Cdd:PRK10337 164 LIPWLVALPIMLIILMVLLGREL-APLKKLALALRMRDPDSETP-LNATGVPSEVRPLvealNQLFAR---THAMMVRER 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 262 RIMlAGISHDLRTPLTRIRLTAEM----LPDEFLRE----GLVYDVDDMDAILNQFISYMRDGSDEELKDT---NINMLL 330
Cdd:PRK10337 239 RFT-SDAAHELRSPLAALKVQTEVaqlsDDDPQARKkallQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVaeiPLEDLL 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 331 QELVV------QFKPLDIQFEMQDVPII-PARSLSLKRLIANLINNAKRY----GAEPIELSAKvenesiLITVADHGEG 399
Cdd:PRK10337 318 QSAVMdiyhtaQQAGIDVRLTLNAHPVIrTGQPLLLSLLVRNLLDNAIRYspqgSVVDVTLNAR------NFTVRDNGPG 391
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 400 IPADQIEELMQPFVR--GDSArtiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIIS 457
Cdd:PRK10337 392 VTPEALARIGERFYRppGQEA---TGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
5.96e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 95.96 E-value: 5.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEPIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQ--GSGLGLAIVKRIVD 436
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRAtgGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|...
gi 488045638 437 IHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWP 103
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
206-460 |
1.74e-23 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 102.79 E-value: 1.74e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 206 RQMNRPLRRLQN-----AANEYSKSGTAPYLDtnhgplEIRQVNQAFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIR 280
Cdd:PRK10549 186 RGLLAPVKRLVEgthklAAGDFTTRVTPTSRD------ELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLR 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 281 LTAEMLPD---EFLREG----------LVYDVDDmdaiLNQfISYMRDGSDEELKD-TNINMLLQELVVQF------KPL 340
Cdd:PRK10549 260 GELEAIQDgvrKFTPESvaslqaevgtLTKLVDD----LHQ-LSLSDEGALAYRKTpVDLVPLLEVAGGAFrerfasRGL 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 341 DIQFEMQDVPIIPARSLSLKRLIANLINNAKRYGAEP--IELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSA 418
Cdd:PRK10549 335 TLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGgsLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGS 414
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 488045638 419 RTIQ--GSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPI 460
Cdd:PRK10549 415 RNRAsgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 458
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
264-467 |
1.72e-22 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 100.05 E-value: 1.72e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 264 MLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVY------DVDDMDAILNQFISYMRDGSDEElKDTNINMLLQELVVQF 337
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKTYldimlsELDRIESIISEFLVLAKPQAIKY-EPKDLNTLIEEVIPLL 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 338 KP------LDIQFE-MQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELS---AKVENESILITVADHGEGIPADQIEE 407
Cdd:COG5809 352 QPqallknVQIELElEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITietKAEDDDKVVISVTDEGCGIPEERLKK 431
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 408 LMQPFvrgdSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPKPSTEE 467
Cdd:COG5809 432 LGEPF----YTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQVS 487
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-458 |
2.57e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 91.70 E-value: 2.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 356 SLSLKRLIANLINNAKRYGAEPIELSAKVENESI-LITVADHGEGIPADQIEELMQPFVRGDSaRTIQGSGLGLAIVKRI 434
Cdd:cd16940 11 ALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGaVIRVEDNGPGIDEEELEALFERFYRSDG-QNYGGSGLGLSIVKRI 89
|
90 100
....*....|....*....|....
gi 488045638 435 VDIHHGEIQIHNREQGGLEVIISL 458
Cdd:cd16940 90 VELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
255-466 |
9.43e-22 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 98.50 E-value: 9.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 255 DQTER---ERRIM-----------LAGISHDLRTPLTRIRLTAEMLPDEFLRE------GLVY-DVDDMDAILNQFISYM 313
Cdd:PRK11360 370 DLTERkrlQRRVArqerlaalgelVAGVAHEIRNPLTAIRGYVQIWRQQTSDPpsqeylSVVLrEVDRLNKVIDQLLEFS 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 314 RDgSDEELKDTNINMLLQELVVQFKPL----DIQFEM---QDVPIIPARSLSLKRLIANLINNAKRYGAEPIELSAKVEN 386
Cdd:PRK11360 450 RP-RESQWQPVSLNALVEEVLQLFQTAgvqaRVDFETeldNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQ 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 387 ES---ILITVADHGEGIPADQIEELMQPFVrgdSARTiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPKP 463
Cdd:PRK11360 529 YSdgqVAVSIEDNGCGIDPELLKKIFDPFF---TTKA-KGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
...
gi 488045638 464 STE 466
Cdd:PRK11360 605 GNQ 607
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
264-461 |
4.71e-21 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 95.95 E-value: 4.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 264 MLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDV-----DDMDAILNQFISYMRDGSDEeLKDTNINMLLQELVvqfk 338
Cdd:COG5805 290 LAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDImlselDRIESIISEFLALAKPQAVN-KEKENINELIQDVV---- 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 339 PL--------DIQFEMQ---DVPIIPARSLSLKRLIANLINNAKRygAEP----IELSAKVENESILITVADHGEGIPAD 403
Cdd:COG5805 365 TLleteailhNIQIRLElldEDPFIYCDENQIKQVFINLIKNAIE--AMPnggtITIHTEEEDNSVIIRVIDEGIGIPEE 442
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 488045638 404 QIEELMQPFVrgdSARTiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIP 461
Cdd:COG5805 443 RLKKLGEPFF---TTKE-KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
319-462 |
1.46e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 90.29 E-value: 1.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 319 EELKDTNINMLLQELVVQFKPLDIQFEMQ---DVPIIPARSLSLKRLIANLINNA-----KRYGAEP-IELSAKVENESI 389
Cdd:COG3290 239 SRIGNPVLAALLLGKAARARERGIDLTIDidsDLPDLPLSDTDLVTILGNLLDNAieaveKLPEEERrVELSIRDDGDEL 318
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488045638 390 LITVADHGEGIPADQIEELmqpFVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPK 462
Cdd:COG3290 319 VIEVEDSGPGIPEELLEKI---FERGFSTKLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
7.80e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 81.74 E-value: 7.80e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAE--PIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSART--IQGSGLGLAIVKRI 434
Cdd:cd16946 5 LQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNraSGGSGLGLAICHNI 84
|
90 100
....*....|....*....|....*
gi 488045638 435 VDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16946 85 ALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
320-458 |
2.41e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 81.14 E-value: 2.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 320 ELKDTNINMLlqELVVQFKPLDIQFEMQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELSAKVENESILITVADHGEG 399
Cdd:cd16954 1 PLLDSLCSAL--NKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 488045638 400 IPADQIEELMQPFVRGDSARtiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISL 458
Cdd:cd16954 79 VPESQRSKIFQRGQRLDEQR--PGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
359-459 |
5.79e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 79.46 E-value: 5.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAE-PIELSAKVENES-----ILITVADHGEGIPADQIEELMQPFVRGDSA--RTIQGSGLGLAI 430
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEgEVTLRVSLEEEEedgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSttRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 488045638 431 VKRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-445 |
9.17e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 78.58 E-value: 9.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEP--IELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVD 436
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENtrIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80
|
....*....
gi 488045638 437 IHHGEIQIH 445
Cdd:cd16923 81 LHGGSASAE 89
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
205-459 |
1.71e-17 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 84.82 E-value: 1.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 205 VRQMNRPLRRLQNAANEYSKSGTAPYLDTNHGPLEIRQVNQAFNRMVYTLDQTERERRIMLAGISHDLRTPLT------R 278
Cdd:PRK09835 206 VHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITnlitqtE 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 279 IRLTAEMLPDEFlrEGLVYD-----------VDDM----DAILNQFI--SYMRDGSDEELKdtninmllqelVVQF---- 337
Cdd:PRK09835 286 IALSQSRSQKEL--EDVLYSnleeltrmakmVSDMlflaQADNNQLIpeKKMLDLADEVGK-----------VFDFfeaw 352
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 338 ---KPLDIQFEmQDVPIIPARSLSLKRLIANLINNAKRY--GAEPIELSAKVENESILITVADHGEGIPADQIEELMQPF 412
Cdd:PRK09835 353 aeeRGVELRFV-GDPCQVAGDPLMLRRAISNLLSNALRYtpAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRF 431
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 488045638 413 VRGDSARTI--QGSGLGLAIVKRIVDIHHGEIQIHNrEQGGLEVIISLP 459
Cdd:PRK09835 432 YRVDPSRQRkgEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
249-459 |
6.99e-17 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 82.75 E-value: 6.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 249 RMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLrEGLVYD---------VDDMDAILNQF--ISYMRDGS 317
Cdd:PRK11006 192 RDVTQMHQLEGARRNFFANVSHELRTPLTVLQGYLEMMQDQPL-EGALREkalhtmreqTQRMEGLVKQLltLSKIEAAP 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 318 DEELKDT-NINMLLQELVVQFKPL-----DIQFEMQDVPIIPARSLSLKRLIANLINNAKRY---GAEpIELSAKVENES 388
Cdd:PRK11006 271 TIDLNEKvDVPMMLRVLEREAQTLsqgkhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHtpeGTH-ITVRWQRVPQG 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488045638 389 ILITVADHGEGIPADQIEELMQPFVRGDSARTIQ--GSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:PRK11006 350 AEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQtgGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
266-460 |
4.47e-16 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 80.22 E-value: 4.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 266 AGISHDLRTPLTRI----RLTAEMLP----DEFLREGLVYDVDDMDAILNQFISYMRDgSDEELKDTNINMLLQ---ELV 334
Cdd:PRK10364 242 AGVAHEIRNPLSSIkglaKYFAERAPaggeAHQLAQVMAKEADRLNRVVSELLELVKP-THLALQAVDLNDLINhslQLV 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 335 VQ---FKPLDIQFEMQD-VPIIPARSLSLKRLIANLINNA----KRYGAepIELSAKVENESILITVADHGEGIPADQIE 406
Cdd:PRK10364 321 SQdanSREIQLRFTANDtLPEIQADPDRLTQVLLNLYLNAiqaiGQHGV--ISVTASESGAGVKISVTDSGKGIAADQLE 398
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 488045638 407 ELMQPFVRGDSartiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPI 460
Cdd:PRK10364 399 AIFTPYFTTKA----EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
206-462 |
1.36e-15 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 78.91 E-value: 1.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 206 RQMNRPLRRLQNAANEYSKsGTAPYLDTNhGPLEIRQVNQAFNRMVYTL-----DQTERERRIMLAGIS--------HDL 272
Cdd:COG2972 179 RSITRPIKRLKKAMKKVEK-GDLVRLEVS-GNDEIGILARSFNEMVERIkelieEVYELELEKKEAELKalqaqinpHFL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 273 RTPLTRIRLTAEMlpdeflreglvYDVDDMDAILNQFISYMR----DGSD-----EELKdtNINMLLQELVVQFKP-LDI 342
Cdd:COG2972 257 FNTLNSIRWLAEL-----------EDPEEAEEMLEALSKLLRyslsKGDElvtleEELE--LIKSYLEIQKLRFGDrLEV 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 343 QFEMQDVPIipaRSLSLKRLIANLINNAKRYGAEP------IELSAKVENESILITVADHGEGIPADQIEELMQPFVRGD 416
Cdd:COG2972 324 EIEIDEELL---DLLIPKLILQPLVENAIEHGIEPkegggtIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSKG 400
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 488045638 417 sartiQGSGLGLAIVKRIVDIHHGE---IQIHNREQGGLEVIISLPIPK 462
Cdd:COG2972 401 -----EGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPLEE 444
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
359-459 |
1.63e-15 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 72.53 E-value: 1.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEPIELSAKVE---NESILITVADHGEGIPADQIEELMQPF--VRGDSARTIQGSGLGLAIVKR 433
Cdd:cd16925 5 YERVVLNLLSNAFKFTPDGGRIRCILEkfrLNRFLLTVSDSGPGIPPNLREEIFERFrqGDGSSTRAHGGTGLGLSIVKE 84
|
90 100
....*....|....*....|....*.
gi 488045638 434 IVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16925 85 FVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-452 |
5.30e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 70.95 E-value: 5.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEP--IELSAKVENESILITVADHGEGIPADQIEELMQPFV---RGDSARtiQGSGLGLAIVKR 433
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGglIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYslpRPHSGQ--KSTGLGLAFVQE 82
|
90
....*....|....*....
gi 488045638 434 IVDIHHGEIQIHNREQGGL 452
Cdd:cd16945 83 VAQLHGGRITLRNRPDGVL 101
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
4.02e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 68.33 E-value: 4.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRY--GAE--PIELSAKVE---NESILITVADHGEGIPADQIEELMQPFVRGDSArtiqGSGLGLAIV 431
Cdd:cd16944 5 ISQVLTNILKNAAEAieGRPsdVGEVRIRVEadqDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPK----GTGLGLAIV 80
|
90 100
....*....|....*....|....*...
gi 488045638 432 KRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16944 81 KKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-456 |
8.31e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 67.49 E-value: 8.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEPIELSAKVENESILIT--VADHGEGIPADQIEELMQPFVRGDSARTIQG-SGLGLAIVKRIV 435
Cdd:cd16975 5 LSRALINIISNACQYAPEGGTVSISIYDEEEYLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIAKNLV 84
|
90 100
....*....|....*....|.
gi 488045638 436 DIHHGEIQIHNREQGGLEVII 456
Cdd:cd16975 85 EKHGGSLIIENSQKGGAEVTV 105
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
255-463 |
1.15e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 73.79 E-value: 1.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 255 DQTERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREGLVYDV-------DDMDAILNQFISYmrdgSDEELKDTNIN 327
Cdd:PRK11466 438 EKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLraitdsgESLLTILNDILDY----SAIEAGGKNVS 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 328 M---------LLQELV------VQFKPLDIQFEMQD-VPII----PARslsLKRLIANLINNAKRYGAE-PIELSAKVEN 386
Cdd:PRK11466 514 VsdepfeprpLLESTLqlmsgrVKGRPIRLATDIADdLPTAlmgdPRR---IRQVITNLLSNALRFTDEgSIVLRSRTDG 590
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488045638 387 ESILITVADHGEGIPADQIEELMQPFVRGDSARTiqGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPKP 463
Cdd:PRK11466 591 EQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPLRVA 665
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
2.64e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 65.88 E-value: 2.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNA----KRYGAEPIELSAKVE---NESILITVADHGEGIPADQIEELMQPFVRGDSartiQGSGLGLAIV 431
Cdd:cd16920 1 IQQVLINLVRNGieamSEGGCERRELTIRTSpadDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKS----EGLGMGLSIC 76
|
90 100
....*....|....*....|....*...
gi 488045638 432 KRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16920 77 RSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
254-442 |
8.81e-13 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 69.59 E-value: 8.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 254 LDQTERERRI--MLAgisHDLRTPLTRIRLTAEMLPDEFLREGLVYDVDDMDAILNQFISYMRD-------------GSD 318
Cdd:PRK09303 145 LEQLKFKDRVlaMLA---HDLRTPLTAASLALETLELGQIDEDTELKPALIEQLQDQARRQLEEierlitdllevgrTRW 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 319 EELK----DTNINMLLQELVVQFKPL----DIQFEM---QDVPIIPARSLSLKRLIANLINNAKRYGAE--PIELSA--- 382
Cdd:PRK09303 222 EALRfnpqKLDLGSLCQEVILELEKRwlakSLEIQTdipSDLPSVYADQERIRQVLLNLLDNAIKYTPEggTITLSMlhr 301
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488045638 383 ---KVEnesilITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEI 442
Cdd:PRK09303 302 ttqKVQ-----VSICDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQI 359
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-459 |
1.19e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 63.85 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 363 IANLINNA----KRYGAEP--IELSAKVENESILITVADHGEGIPADQIEELmqpFVRGDSARTIQGSGLGLAIVKRIVD 436
Cdd:cd16915 5 VGNLIDNAldalAATGAPNkqVEVFLRDEGDDLVIEVRDTGPGIAPELRDKV---FERGVSTKGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 488045638 437 IHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
240-459 |
2.15e-12 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 68.74 E-value: 2.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 240 IRQVNQAFNRMVYTldqtERERRI--MLAGISHDLRTPLTRIR-----LTAEMLPDEFLREGLVYDVDDMD---AILNQF 309
Cdd:COG5806 182 LIENILLRKELQRA----EKLEVVseLAASIAHEVRNPLTVVRgfiqlLQEPELSDEKRKQYIRIALEELDraeAIITDY 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 310 ISYMRDGSdEELKDTNINMLLQELVVQFKPL------DIQFEMQDVPIIPARSLSLKRLIANLINNakryGAEPIE---- 379
Cdd:COG5806 258 LTFAKPQP-EKLEKIDVSEELEHVIDVLSPYanmnnvEIQTELEPGLYIEGDRQKLQQCLINIIKN----GIEAMPnggt 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 380 --LSAKVENESILITVADHGEGIPADQIEELMQPFVrgdSARTiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIIS 457
Cdd:COG5806 333 ltIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYF---STKE-KGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTIT 408
|
..
gi 488045638 458 LP 459
Cdd:COG5806 409 LP 410
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
4.29e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 62.34 E-value: 4.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRY---GAEP-IELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRI 434
Cdd:cd16921 1 LGQVLTNLLGNAIKFrrpRRPPrIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 488045638 435 VDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
265-460 |
4.89e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 68.46 E-value: 4.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 265 LAGISHDLRTPLTRI-----RLTAEMLPDEFLRegLVYDVDDMDAILNQFISYMRDGS---DEELKD-----------TN 325
Cdd:PRK10841 451 LATVSHELRTPLYGIignldLLQTKELPKGVDR--LVTAMNNSSSLLLKIISDILDFSkieSEQLKIeprefspreviNH 528
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 326 INMLLQELVVQfKPLDIQ-FEMQDVPII----PARslsLKRLIANLINNAKRY---GAepIELSAKVENESILITVADHG 397
Cdd:PRK10841 529 ITANYLPLVVK-KRLGLYcFIEPDVPVAlngdPMR---LQQVISNLLSNAIKFtdtGC--IVLHVRVDGDYLSFRVRDTG 602
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488045638 398 EGIPADQIEELMQPFVRGDSA--RTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPI 460
Cdd:PRK10841 603 VGIPAKEVVRLFDPFFQVGTGvqRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
254-476 |
2.08e-11 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 66.50 E-value: 2.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 254 LDQTERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFL-REGLVY----------------DVDDMDAI-------LNQ- 308
Cdd:PRK11091 276 LEKASRDKTTFISTISHELRTPLNGIVGLSRILLDTELtAEQRKYlktihvsaitlgnifnDIIDMDKMerrklqlDNQp 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 309 --FISYMrdgsdEELKdtNINMLLQElvvqfkPLDIQFEM---QDVPI-IPARSLSLKRLIANLINNAKRYGAE-PIELS 381
Cdd:PRK11091 356 idFTDFL-----ADLE--NLSGLQAE------QKGLRFDLeplLPLPHkVITDGTRLRQILWNLISNAVKFTQQgGVTVR 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 382 AKVE-NESILITVADHGEGIPADQIEEL--MQPFVR-GDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIIS 457
Cdd:PRK11091 423 VRYEeGDMLTFEVEDSGIGIPEDELDKIfaMYYQVKdSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLT 502
|
250
....*....|....*....
gi 488045638 458 LPIPKPSTEENTTTNPLEK 476
Cdd:PRK11091 503 IHAPAVAEEVEDAFDEDDM 521
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
258-463 |
2.59e-11 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 63.87 E-value: 2.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 258 ERER-RI----------MLAGISHDLRTPLTRIRLTAEMLPDEF--LREGLVYDVDDMDAILnqfisymRDGSDEELKDT 324
Cdd:COG4585 51 EEERrRIarelhdgvgqSLSAIKLQLEAARRLLDADPEAAREELeeIRELAREALAELRRLV-------RGLRPPALDDL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 325 NINMLLQELVVQFK-----PLDIQFEMQDVPIIPARSLSLKRLIANLINNAKRY-GAEPIELSAKVENESILITVADHGE 398
Cdd:COG4585 124 GLAAALEELAERLLraagiRVELDVDGDPDRLPPEVELALYRIVQEALTNALKHaGATRVTVTLEVDDGELTLTVRDDGV 203
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488045638 399 GIPADQIEelmqpfvrgdsartiqGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPIPKP 463
Cdd:COG4585 204 GFDPEAAP----------------GGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-460 |
2.92e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 60.13 E-value: 2.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNA----KRYGAEPIELSAKVEneSILITVADHGEGIPADQIEELMQPFVrgdSARTI-QGSGLGLAIVKR 433
Cdd:cd16943 4 LNQVLLNLLVNAaqamEGRGRITIRTWAHVD--QVLIEVEDTGSGIDPEILGRIFDPFF---TTKPVgEGTGLGLSLSYR 78
|
90 100
....*....|....*....|....*..
gi 488045638 434 IVDIHHGEIQIHNREQGGLEVIISLPI 460
Cdd:cd16943 79 IIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
210-455 |
3.10e-11 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 65.42 E-value: 3.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 210 RPLRRLQNAANEYSKsGTAPYLDTNhGPLEIRQVNQAFNRMVytldQTERER----RIMLAGISHDLRTPLTRIRLTAEM 285
Cdd:PRK10815 217 RPIEALAKQVRELEE-GEREQLDPN-PPRELTSLVRNLNRLL----KNERERytkyRTTLTDLTHSLKTPLAVLQSTLRS 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 286 LpdeflREGLVYDVDDMDAIL-------NQFISY------MRDGSDEELKDTN-INMLLQEL------VVQFK----PLD 341
Cdd:PRK10815 291 L-----RSGKQMSVEQAEPIMleqisriSQQIGYylhrasMRSEHNLLSRELHsVAPLLDNLtsalnkVYQRKgvniTLD 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 342 IQFEMQDVpiipARSLSLKRLIANLINNAKRYGAEPIELSAKVENESILITVADHGEGIPADQIEELmqpFVRGDSARTI 421
Cdd:PRK10815 366 ISPEITFV----GEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELI---FDRGQRADTL 438
|
250 260 270
....*....|....*....|....*....|....*..
gi 488045638 422 Q-GSGLGLAIVKRIVDIHHGEIQIHNREQGG--LEVI 455
Cdd:PRK10815 439 RpGQGLGLSVAREITEQYEGKISAGDSPLGGarMEVI 475
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
229-473 |
8.63e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 64.31 E-value: 8.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 229 PYLDTNHGplEIRQVNQAFNRMVYTLD----QTER---ERRIMLA-----------GISHDLRTPLTRIRLTAEM----L 286
Cdd:PRK13837 402 YGLRPPAG--ELQLLELALDCLAHAIErrrlETERdalERRLEHArrleavgtlasGIAHNFNNILGAILGYAEMalnkL 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 287 PD-----EFLREgLVYDVDDMDAILNQFISYMRDGsDEELKDTNINMLLQELVVQFK-----PLDIQFEMQDVP-IIPAR 355
Cdd:PRK13837 480 ARhsraaRYIDE-IISAGARARLIIDQILAFGRKG-ERNTKPFDLSELVTEIAPLLRvslppGVELDFDQDQEPaVVEGN 557
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 356 SLSLKRLIANLINNA---------------KRYGAEPIELSAKV--ENESILITVADHGEGIPADQIEELMQPFVrgdSA 418
Cdd:PRK13837 558 PAELQQVLMNLCSNAaqamdgagrvdislsRAKLRAPKVLSHGVlpPGRYVLLRVSDTGAGIDEAVLPHIFEPFF---TT 634
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 488045638 419 RTiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPI-PKPSTEENTTTNP 473
Cdd:PRK13837 635 RA-GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPsSKVPVAPQAFFGP 689
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
1.05e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 58.74 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEP---IELSAKVENESILITVADHGEGIPADQIEELMQPFV--RGDSARTIQGSGLGLAIVKR 433
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtgrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYteRPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 488045638 434 IVDIHHGEIQIHNREQG----GLEVIISLP 459
Cdd:cd16953 81 IIEAHGGISVAENHNQPgqviGARFTVQLP 110
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
365-459 |
1.24e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 58.57 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 365 NLINNA----KRYGAEpIELSAKVENE----------SILITVADHGEGIPADQIEELMQPFVRGDSartiQGSGLGLAI 430
Cdd:cd16918 7 NLVRNAaqalAGSGGE-IILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPMVSGRE----NGTGLGLAI 81
|
90 100
....*....|....*....|....*....
gi 488045638 431 VKRIVDIHHGEIQIHNREqGGLEVIISLP 459
Cdd:cd16918 82 AQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-444 |
1.39e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 58.37 E-value: 1.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAEPIELSAK--VENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQ--GSGLGLAIVKRI 434
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRwsQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNtgGTGLGLAIVKHV 80
|
90
....*....|
gi 488045638 435 VDIHHGEIQI 444
Cdd:cd16952 81 MSRHDARLLI 90
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
231-482 |
1.57e-10 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 63.51 E-value: 1.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 231 LDT---NHGPLEIR--QVNQAFNRMVYTLDQTERERRIMLAGISHDLRTPLTRIRLTAEML------PDEF-LREGLVYD 298
Cdd:PRK15347 363 LDTlneQYDTLENKvaERTQALAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLqntpltAEQMdLADTARQC 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 299 VDDMDAILNQFISYMRDGSDE---ELKDTNI------NMLLQELVVQFKPLDIQ-FEMQDVPIIPA-RSLSLKRLIANLI 367
Cdd:PRK15347 443 TLSLLAIINNLLDFSRIESGQmtlSLEETALlplldqAMLTIQGPAQSKSLTLRtFVGAHVPLYLHlDSLRLRQILVNLL 522
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 368 NNA-KRYGAEPIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSarTIQGSGLGLAIVKRIVDIHHGEIQIHN 446
Cdd:PRK15347 523 GNAvKFTETGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT--HSQGTGLGLTIASSLAKMMGGELTLFS 600
|
250 260 270
....*....|....*....|....*....|....*.
gi 488045638 447 REQGGLEVIISLPIpkpsteenTTTNPLEKIKQTLS 482
Cdd:PRK15347 601 TPGVGSCFSLVLPL--------NEYAPPEPLKGELS 628
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-447 |
1.02e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 56.37 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 358 SLKRLIANLINNAKRYGAEP--IELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSART--IQGSGLGLAIVKR 433
Cdd:cd16947 20 ALQRILKNLISNAIKYGSDGkfLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsaKQGNGLGLTITKR 99
|
90
....*....|....
gi 488045638 434 IVDIHHGEIQIHNR 447
Cdd:cd16947 100 LAESMGGSIYVNSK 113
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-458 |
3.54e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 54.00 E-value: 3.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNA-----KRygAEP-IELSAKVENESILITVADHGEGIPADQIEELMQPFVrgdSARTI-QGSGLGLAIV 431
Cdd:cd16976 1 IQQVLMNLLQNAldamgKV--ENPrIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF---TTKPVgKGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 488045638 432 KRIVDIHHGEIQIHNREQGGLEVIISL 458
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
362-460 |
1.05e-08 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 53.38 E-value: 1.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 362 LIANLINNAKRYGAE-PIELSAKVENESILITVADHGEGIPADQIEelmqpfvrgDSARTIQGSGLGLAIVKRIVDihhg 440
Cdd:COG2172 42 AVTNAVRHAYGGDPDgPVEVELELDPDGLEIEVRDEGPGFDPEDLP---------DPYSTLAEGGRGLFLIRRLMD---- 108
|
90 100
....*....|....*....|
gi 488045638 441 EIQIHnREQGGLEVIISLPI 460
Cdd:COG2172 109 EVEYE-SDPGGTTVRLVKRL 127
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
268-459 |
1.70e-08 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 57.00 E-value: 1.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 268 ISHDLRTPLTRI-------RLTAEMLPDEFLREGLVYD---VDDMDAILNQFISYMRDGsDEELKDTNINMLLQ---ELV 334
Cdd:COG4192 440 LAHELNQPLNAMsmylfsaKKALEQENYAQLPTSLDKIeglIERMDKIIKSLRQFSRKS-DTPLQPVDLRQVIEqawELV 518
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 335 -VQFKPLDIQFEMQDVPIIPARSLSLKRLIANLINNAKRYGAEP--IELSAKVENESILITVADHGEGIPAdqIEELMQP 411
Cdd:COG4192 519 eSRAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQpqISVDLLSNAENLRVAISDNGNGWPL--VDKLFTP 596
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 488045638 412 FVrgdSARTIqGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:COG4192 597 FT---TTKEV-GLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
260-314 |
2.87e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 50.29 E-value: 2.87e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488045638 260 ERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREG-------LVYDVDDMDAILNQFISYMR 314
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEqreyletILRSAERLLRLINDLLDLSR 62
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
258-314 |
7.08e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 49.13 E-value: 7.08e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488045638 258 ERERRIMLAGISHDLRTPLTRIRLTAEMLPDEFLREG--------LVYDVDDMDAILNQFISYMR 314
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEeqreylerIREEAERLLRLINDLLDLSR 65
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
326-465 |
8.88e-08 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 54.53 E-value: 8.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 326 INMLLQELVVQFKPLDIQFEMQ--DVPIIPARSLSLKrLIAN-LINNAKRYGAEP-----IELSAKVENESILITVADHG 397
Cdd:COG3920 365 LRELLEPLRDSYGGRGIRIELDgpDVELPADAAVPLG-LILNeLVTNALKHAFLSgeggrIRVSWRREDGRLRLTVSDNG 443
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488045638 398 EGIPADqieelmqpfvrgdsARTIQGSGLGLAIVKRIVDIHHGEIQIHNREqgGLEVIISLPIPKPST 465
Cdd:COG3920 444 VGLPED--------------VDPPARKGLGLRLIRALVRQLGGTLELDRPE--GTRVRITFPLAELAA 495
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
260-314 |
1.72e-07 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 48.33 E-value: 1.72e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488045638 260 ERRIMLAGISHDLRTPLTRIRLTAEML-------PDEFLREGLVYDVDDMDAILNQFISYMR 314
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLldtelseEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
2.16e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 49.21 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNAKRYGAE--PIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQGS-GLGLAIVKRIV 435
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQggKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQEStGMGLYLVKKLC 85
|
90 100
....*....|....*....|....
gi 488045638 436 DIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16948 86 DKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
361-457 |
4.36e-07 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 48.82 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 361 RLIAN-LINNAKRYG-----AEPIELSAKVENESILITVADHGEGIPADQIEelmqPFVRGDSARTIQGSGLGLAIVKRI 434
Cdd:pfam13581 33 ELAVGeACTNAVEHAyregpEGPVEVRLTSDGGGLVVTVADSGPPFDPLTLP----PPDLEEPDEDRKEGGRGLALIRGL 108
|
90 100
....*....|....*....|...
gi 488045638 435 VDihhgEIQIHnREQGGLEVIIS 457
Cdd:pfam13581 109 MD----DVEYT-RGGEGNTVRMR 126
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
389-459 |
7.73e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 47.76 E-value: 7.73e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488045638 389 ILITVADHGEGIPADQIEELMQPFVrgdSARTI-QGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFF---TTKEVgKGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
265-460 |
8.95e-07 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 51.66 E-value: 8.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 265 LAGISHDLRTPLTRIRLTAEMLPDEFLRE------------------GLVYDVDDMDAIlnqfisymrDGSDEELKD--T 324
Cdd:PRK09959 716 LATMSHEIRTPISSIMGFLELLSGSGLSKeqrveaislayatgqsllGLIGEILDVDKI---------ESGNYQLQPqwV 786
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 325 NINMLLQELVVQFKP--------LDIQFEMQDVPIIPARSLSLKRLIANLINNAKRYGAE-PIELSAKV----ENESIL- 390
Cdd:PRK09959 787 DIPTLVQNTCHSFGAiaasksiaLSCSSTFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEgAVKITTSLghidDNHAVIk 866
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 391 ITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPI 460
Cdd:PRK09959 867 MTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
238-460 |
1.37e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 50.08 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 238 LEIRQVNQAfNRMVYTLDQTERER--RIMLAGISHDLRTPLTRIR----LTAEMLPDEFLREG---LVYDVDDMDAILNQ 308
Cdd:PRK11073 106 LEMAPMDNQ-RRLSQEQLQHAQQVaaRDLVRGLAHEIKNPLGGLRgaaqLLSKALPDPALTEYtkvIIEQADRLRNLVDR 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 309 FISYMRDGsdeELKDTNINMLLqELVVQFkpldIQFEMQD-----------VPIIPARSLSLKRLIANLINNAKRYGAEP 377
Cdd:PRK11073 185 LLGPQRPG---THVTESIHKVA-ERVVQL----VSLELPDnvrlirdydpsLPELAHDPDQIEQVLLNIVRNALQALGPE 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 378 ---IELSAKVENESIL----------ITVADHGEGIPADQIEELMQPFVRGDSArtiqGSGLGLAIVKRIVDIHHGEIQI 444
Cdd:PRK11073 257 ggtITLRTRTAFQLTLhgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSGREG----GTGLGLSIARNLIDQHSGKIEF 332
|
250
....*....|....*.
gi 488045638 445 hNREQGGLEVIISLPI 460
Cdd:PRK11073 333 -TSWPGHTEFSVYLPI 347
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
366-450 |
1.49e-06 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 46.11 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 366 LINNAKRYG-----AEPIELSAKVENESILITVADHGEGIPadqieelmqPFVRGDSARTIQGSGLGLAIVKRIVDihhg 440
Cdd:cd16936 8 AVTNAVRHAyrhdgPGPVRLELDLDPDRLRVEVTDSGPGFD---------PLRPADPDAGLREGGRGLALIRALMD---- 74
|
90
....*....|
gi 488045638 441 EIQIHNREQG 450
Cdd:cd16936 75 EVGYRRTPGG 84
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-459 |
4.64e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 45.13 E-value: 4.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 366 LINNAKRYGAEP------IELSAKVENESILITVADHGEGIPADQIEELmqpfvrgdSARTIQGSGLGLAIVKRIVDIHH 439
Cdd:cd16924 9 LVENAIQHGLSPltdkgvVTISALKEDNHVMIEVEDNGRGIDPKVLNIL--------GKKPKEGNGIGLYNVHQRLILLF 80
|
90 100
....*....|....*....|...
gi 488045638 440 GE---IQIHNREQGGLEVIISLP 459
Cdd:cd16924 81 GEdygIHIASEPDKGTRITFTIP 103
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
332-450 |
7.26e-06 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 48.69 E-value: 7.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 332 ELVvqfkpLDIQfemQDVP--II--PARslsLKRLIANLINNAKRY---GAEPIELS-AKVENESILI--TVADHGEGIP 401
Cdd:PRK11107 389 ELT-----LNID---PDVPdnVIgdPLR---LQQIITNLVGNAIKFtesGNIDILVElRALSNTKVQLevQIRDTGIGIS 457
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 488045638 402 ADQIEELMQPFVRGDS--ARTIQGSGLGLAIVKRIVDIHHGEIQIHNR-EQG 450
Cdd:PRK11107 458 ERQQSQLFQAFRQADAsiSRRHGGTGLGLVITQKLVNEMGGDISFHSQpNRG 509
|
|
| HATPase_EL346-LOV-HK-like |
cd16951 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
302-459 |
1.53e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.
Pssm-ID: 340427 [Multi-domain] Cd Length: 131 Bit Score: 44.33 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 302 MDAILNQFISYMRDGSDEelKDTNINMllqelVVQFKPLDIQFEMqdvpiipARSLSLKRLIANLINNAKRYGAE-PIEL 380
Cdd:cd16951 1 LGEYINRIASAINAIHAV--GDIRINI-----TGDTGPVSSEVAT-------AIGLVVNELLQNALKHAFSDREGgTITI 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 381 SAKVENESILITVADHGEGIPADqieelmqpfvrGDSARtiQGSgLGLAIVKRIV-DIHHGEIQIHNREQgGLEVIISLP 459
Cdd:cd16951 67 RSVVDGDYLRITVIDDGVGLPQD-----------EDWPN--KGS-LGLQIVRSLVeGELKAFLEVQSAEN-GTRVNIDIP 131
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
22-458 |
4.27e-05 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 46.26 E-value: 4.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 22 RTRWERFLDKIKPRSAAMRTTILVLLVVFFSLFMSLWFFWRTLYLPEIQQHARYLAVELELVNNPDIRIFHRENEVDIDA 101
Cdd:COG2770 55 LLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLAL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 102 WLRNRVGIEYVTNPKEYPSVREKVIAEFFTNHVEKKLANEIGTKDVTVYFQFKPSPRIWIQtpemhGNWVREPLKTYANY 181
Cdd:COG2770 135 LLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLL-----GGLLLVVLLEAALA 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 182 SPELLVGWVVGVPLLSAIIILILVRQMNRPLRRLQNAANEYSKSGTAPYLDTnHGPLEIRQVNQAFNRMVYTLDQTERER 261
Cdd:COG2770 210 ALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPV-SRKDEIGELARAFNRMADSLRESIEEA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 262 RIMLAGISHDLR--TPLTRIRLTAEMLPDEFLREGLVYDVDDMDAILNQFISYMRDGSDEELKDTNINMLLQELVVQFKP 339
Cdd:COG2770 289 EEEEELAEAELArlLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELL 368
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 340 LDIQFEMQDVPIIPARSLSLKRLIANLINNAKRYGAEPIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSAR 419
Cdd:COG2770 369 LEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAA 448
|
410 420 430
....*....|....*....|....*....|....*....
gi 488045638 420 TIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISL 458
Cdd:COG2770 449 AAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGAL 487
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
363-445 |
2.82e-04 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 43.36 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 363 IANLINNA----KRYGAEPIELSAKVENESILITVADHGEGIPADQIEELmqpFVRGDSARTiQGSGLGLAIVKRIVDIH 438
Cdd:PRK11086 438 LGNLIENAleavGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAI---FDKGYSTKG-SNRGVGLYLVKQSVENL 513
|
....*..
gi 488045638 439 HGEIQIH 445
Cdd:PRK11086 514 GGSIAVE 520
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
302-449 |
3.80e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 40.64 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 302 MDAILNQFISYMRDgsdeelkdtninmllqelvvqfKPLDIQFEMQDVPIIPARSLSLKRLIANLINNA----------K 371
Cdd:cd16935 2 LDSLLSEKLELARE----------------------KGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAieacakidkeN 59
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488045638 372 RYgaepIELSAKVENESILITVADHGEGIPADQIEELMqpfvrgdSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQ 449
Cdd:cd16935 60 RF----IHLKIRQKKGFLIISIENSYEGELKKKNGLFL-------STKKDKNHGIGLKSIREIVKKYNGNLSIEYENG 126
|
|
| HAMP |
pfam00672 |
HAMP domain; |
205-251 |
4.67e-04 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 37.99 E-value: 4.67e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 488045638 205 VRQMNRPLRRLQNAANEYSkSGTAPYLDTNHGPLEIRQVNQAFNRMV 251
Cdd:pfam00672 3 ARRILRPLRRLAEAARRIA-SGDLDVRLPVSGRDEIGELARAFNQMA 48
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-459 |
5.04e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 39.33 E-value: 5.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 359 LKRLIANLINNA---KRYGAEpIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSartiqGSGLGLAIVKRIV 435
Cdd:cd16957 6 LQVLVENAIRHAfpkRKENNE-VRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSEK-----GTGTALENLNRRL 79
|
90 100
....*....|....*....|....*..
gi 488045638 436 DIHHGE---IQIHNREQGGLEVIISLP 459
Cdd:cd16957 80 IGLFGSeacLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
366-459 |
7.10e-04 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 40.64 E-value: 7.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 366 LINNAKRYGAEP--------------IELSAKVENESILITVADHGEGIPADQIEE------------------------ 407
Cdd:cd16916 46 LLRNAVDHGIEApeerlaagkppegtITLRAEHQGNQVVIEVSDDGRGIDREKIREkaierglitadeaatlsddevlnl 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 488045638 408 LMQP-FVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16916 126 IFAPgFSTAEQVTDVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| PRK11644 |
PRK11644 |
signal transduction histidine-protein kinase/phosphatase UhpB; |
329-459 |
7.60e-04 |
|
signal transduction histidine-protein kinase/phosphatase UhpB;
Pssm-ID: 236945 [Multi-domain] Cd Length: 495 Bit Score: 41.89 E-value: 7.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 329 LLQELVVQFKPLDIQFEMQ--DVPIIPARSLSLKRLIANLINNAKRYG-AEPIELSAKVENESILITVADHGEGIPadqI 405
Cdd:PRK11644 379 LMREMELEDRGIVSHLDWRidESALSETQRVTLFRVCQEGLNNIVKHAdASAVTLQGWQQDERLMLVIEDDGSGLP---P 455
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 488045638 406 EELMQpfvrgdsartiqgsGLGLAIVKRIVDIHHGEIQIHNreQGGLEVIISLP 459
Cdd:PRK11644 456 GSGQQ--------------GFGLRGMRERVTALGGTLTISC--THGTRLSVSLP 493
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
391-460 |
1.48e-03 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 41.19 E-value: 1.48e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488045638 391 ITVADHGEGIPADQIEELMQPF--VRGDSartiQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLPI 460
Cdd:PRK13557 327 IAVTDTGSGMPPEILARVMDPFftTKEEG----KGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
206-259 |
2.43e-03 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 36.07 E-value: 2.43e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 488045638 206 RQMNRPLRRLQNAANEYSKSGTAPYLDTnHGPLEIRQVNQAFNRMVYTLDQTER 259
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPV-DGRDEIGELARAFNEMADRLEETIA 53
|
|
| HATPase_PDK-like |
cd16929 |
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ... |
341-459 |
3.21e-03 |
|
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.
Pssm-ID: 340406 [Multi-domain] Cd Length: 169 Bit Score: 38.48 E-value: 3.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 341 DIQFEmQDVPI-IPARSLSLKRLIANLINNAKR----------YGAEPIELSAKVENESILITVADHGEGIPADQIEELM 409
Cdd:cd16929 26 ELEIE-GDPSIrFPYVPSHLYYILFELLKNAMRatveshgddsDDLPPIKVTVAKGDEDLTIKISDRGGGIPREDLARLF 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488045638 410 ---------------QPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEIQIHNREQGGLEVIISLP 459
Cdd:cd16929 105 symystapqpslddfSDLISGTQPSPLAGFGYGLPMSRLYAEYFGGDLDLQSMEGYGTDVYIYLK 169
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
206-458 |
7.11e-03 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 38.71 E-value: 7.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 206 RQMNRPLRRLQNAANEYSKSGTAPYLDTnHGPLEIRQVNQAFNRMVYTLDQTERE---RRIMLAGISHDLRTPLTRIRLT 282
Cdd:COG3850 140 RRIVRPLRRLTQAAERIARGDFDARVPV-SGRDELGTLARAFNRMADELQELYAEleeEEELEAELELLALLDELLLLAA 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 283 AEMLPDEFLREGLVYDVDDMDAILNQFISYMRDGSDEELKDTNINMLLQELVVQFKPLDIQFEMQDVPIIPARSLSLKRL 362
Cdd:COG3850 219 LLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLAL 298
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 363 IANLINNAKRYGAEPIELSAKVENESILITVADHGEGIPADQIEELMQPFVRGDSARTIQGSGLGLAIVKRIVDIHHGEI 442
Cdd:COG3850 299 AAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQA 378
|
250
....*....|....*.
gi 488045638 443 QIHNREQGGLEVIISL 458
Cdd:COG3850 379 GADAAEALGLLAEASE 394
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
362-462 |
7.17e-03 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 39.05 E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488045638 362 LIANLINNA------KRYGAEPIELSAKVENESILITVADHGEGIPaDQIEELMqpFVRGDSARTIQGS--GLGLAIVKR 433
Cdd:PRK15053 436 IVGNLLDNAfeaslrSDEGNKIVELFLSDEGDDVVIEVADQGCGVP-ESLRDKI--FEQGVSTRADEPGehGIGLYLIAS 512
|
90 100
....*....|....*....|....*....
gi 488045638 434 IVDIHHGEIQIHNREQGGleVIISLPIPK 462
Cdd:PRK15053 513 YVTRCGGVITLEDNDPCG--TLFSIFIPK 539
|
|
| |
