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Conserved domains on  [gi|488135864|ref|WP_002207072|]
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SH3 domain-containing protein [Helicobacter pylori]

Protein Classification

SH3 domain-containing protein( domain architecture ID 11459669)

Src Homology 3 (SH3) domain-containing protein plays versatile and diverse roles in the cell, including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies, among others

CATH:  2.30.30.40
Gene Ontology:  GO:0005515|GO:0070064
PubMed:  28510178|11256992|1639195
SCOP:  4000369

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 134-194 9.50e-14

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


:

Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 64.76  E-value: 9.50e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488135864 134 EYKVIVDSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQNDWAEIEFSHETKGYVFLKLLKKA 194
Cdd:COG3103    6 RYVVDADALNVRSGPGTSYRIVGTLPKGEKVTVLGRSGGWYKVRYSNGKTGWVSSRYLTVT 66
 
Name Accession Description Interval E-value
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 134-194 9.50e-14

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 64.76  E-value: 9.50e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488135864 134 EYKVIVDSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQNDWAEIEFSHETKGYVFLKLLKKA 194
Cdd:COG3103    6 RYVVDADALNVRSGPGTSYRIVGTLPKGEKVTVLGRSGGWYKVRYSNGKTGWVSSRYLTVT 66
SH3b smart00287
Bacterial SH3 domain homologues;
132-193 1.70e-11

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 56.96  E-value: 1.70e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488135864   132 PLEYKVIVDSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQN-DWAEIEFSHETKGYVFLKLLKK 193
Cdd:smart00287   1 SETAVVTGDGLNVRTGPGTSSPIIGTLKKGDKVKVLGVDGqDWAKITYGSGQRGYVPGYVVNT 63
SH3_3 pfam08239
Bacterial SH3 domain;
140-192 2.20e-10

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 53.79  E-value: 2.20e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488135864  140 DSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQND-WAEIEFSHETKGYVFLKLLK 192
Cdd:pfam08239   1 SGLNVRSGPSTSSEVVGTLPKGEKVEVLEEQGGgWYKVRTYDGYEGWVSSSYLS 54
 
Name Accession Description Interval E-value
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 134-194 9.50e-14

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 64.76  E-value: 9.50e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488135864 134 EYKVIVDSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQNDWAEIEFSHETKGYVFLKLLKKA 194
Cdd:COG3103    6 RYVVDADALNVRSGPGTSYRIVGTLPKGEKVTVLGRSGGWYKVRYSNGKTGWVSSRYLTVT 66
SH3b smart00287
Bacterial SH3 domain homologues;
132-193 1.70e-11

Bacterial SH3 domain homologues;


Pssm-ID: 214600 [Multi-domain]  Cd Length: 63  Bit Score: 56.96  E-value: 1.70e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488135864   132 PLEYKVIVDSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQN-DWAEIEFSHETKGYVFLKLLKK 193
Cdd:smart00287   1 SETAVVTGDGLNVRTGPGTSSPIIGTLKKGDKVKVLGVDGqDWAKITYGSGQRGYVPGYVVNT 63
SH3_3 pfam08239
Bacterial SH3 domain;
140-192 2.20e-10

Bacterial SH3 domain;


Pssm-ID: 462405 [Multi-domain]  Cd Length: 54  Bit Score: 53.79  E-value: 2.20e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488135864  140 DSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQND-WAEIEFSHETKGYVFLKLLK 192
Cdd:pfam08239   1 SGLNVRSGPSTSSEVVGTLPKGEKVEVLEEQGGgWYKVRTYDGYEGWVSSSYLS 54
YgiM COG3103
Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family ...
 130-186 5.37e-06

Uncharacterized conserved protein YgiM, contains N-terminal SH3 domain, DUF1202 family [General function prediction only];


Pssm-ID: 442337 [Multi-domain]  Cd Length: 119  Bit Score: 43.96  E-value: 5.37e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488135864 130 KKPLEYKVIVDSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQNDWAEIEFshETKGYV 186
Cdd:COG3103   65 VTPSARERLPDELNLRAGPSTSSEVLGLLPKGETVTVLKKSGGWFKVGY--RGTGWV 119
YraI COG4991
Uncharacterized conserved protein YraI [Function unknown];
137-186 3.25e-04

Uncharacterized conserved protein YraI [Function unknown];


Pssm-ID: 444015 [Multi-domain]  Cd Length: 92  Bit Score: 38.12  E-value: 3.25e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488135864 137 VIVDSVNVRSFPSTKGKIIGSLIKDKSVKVLE--IQNDWAEIEFShETKGYV 186
Cdd:COG4991   26 VATDDLNLRSGPGTGYPVVGTLPAGATVTVLGctSGGGWCKVSYG-GQRGWV 76
SH3 COG3807
SH3-like domain [Function unknown];
137-186 6.71e-03

SH3-like domain [Function unknown];


Pssm-ID: 443020 [Multi-domain]  Cd Length: 150  Bit Score: 35.65  E-value: 6.71e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488135864 137 VIVDSVNVRSFPSTKGKIIGSLIKDKSVKVLEIQNDWAEIEFShETKGYV 186
Cdd:COG3807   87 VTGDLANLRASPDENAAVVARLEPGVVLRLLECDGGWCKVRAD-GYKGWV 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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