|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02414 |
PLN02414 |
glycine dehydrogenase (decarboxylating) |
10-950 |
0e+00 |
|
glycine dehydrogenase (decarboxylating)
Pssm-ID: 178035 [Multi-domain] Cd Length: 993 Bit Score: 1329.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 10 DEFAARHLSFG--DEAALLAAVGEKSMDDFVGNTVPQSIRMPSeLDLP---DALTEADALAKLKGIASKNMINKSYIGLG 84
Cdd:PLN02414 33 DTFPRRHNSATpeEQKAMAEYCGFDSLDALIDATVPKSIRLDS-MKLSkydEGLTESQMLEHMKSLASKNKVFKSYIGMG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 85 YYPTRVPNVILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKVK 164
Cdd:PLN02414 112 YYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNASLLDEGTAAAEAMAMCNNILKGK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 165 SERFFVDERVYPQTLDVMKTRAKYFGFELVVGDFAQAD--EGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIVAVSAD 242
Cdd:PLN02414 192 KKKFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDysSGDVCGVLVQYPATDGEVLDYAEFVKNAHANGVKVVMATD 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 243 IMSLVLLKPPAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRRE 322
Cdd:PLN02414 272 LLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSVDSSGKPALRMAMQTREQHIRRD 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 323 KATSNICTAQALLANLAGMYAVYHGPEGVKRIAKRIHALASAFADALVSDGIKVVHKVFFDTVTVDFGSKektDQVFAAA 402
Cdd:PLN02414 352 KATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQSLPFFDTVKVKCSDA---DAIADAA 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 403 LESGYNLRRVNDTQVAAAFHETSTREDLVDLYRAFTGKDTFAF-----ADDVKGRLNAELLRQNDILQHPVFNSYHTEHE 477
Cdd:PLN02414 429 AKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFtaeslAPEVDSSIPSSLARESPYLTHPIFNQYHSEHE 508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 478 MLRYLKKLEDRDLAMNRSMISLGSCTMKLNATAEMLPITWAEFSDIHPYAPEAQTAGYRELLADMENSLKAITGFDAISF 557
Cdd:PLN02414 509 LLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQGYQEMFEDLGDLLCEITGFDSFSL 588
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 558 QPNSGAQGEYSGMLSIRRYQEANGEGHRNICLIPKSAHGTNPATAAMLGLKVVVVDTDEHGNVNIDDLKAKAEQHRDALS 637
Cdd:PLN02414 589 QPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGTDAKGNINIEELRKAAEAHKDNLA 668
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 638 AIMITYPSTHGVYEEGIRDICRIVHENGGQVYMDGANLNAQIGIMQPAKVGADVLHMNLHKTFCIPHGGGGPGMGPIGLK 717
Cdd:PLN02414 669 ALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHLNLHKTFCIPHGGGGPGMGPIGVK 748
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 718 AHLAPFAPGHTLTDTHSASA-DQT----AVAAAAYGSASILPITWMYLTMMGKQGMEQATRWALLNANYVAKRLGEDYPI 792
Cdd:PLN02414 749 KHLAPFLPSHPVVPTGGIPRpEKTqplgTISAAPWGSALILPISYTYIAMMGSEGLTDASKIAILNANYMAKRLEGHYPV 828
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 793 LYTGKNGRVAHECIVDLRPLKAESGITETDIAKRLMDYGFHAPTVSFPVAGTLMIEPTESESKAELDRFIAALKSIRREV 872
Cdd:PLN02414 829 LFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEPTESESKAELDRFCDALISIREEI 908
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488158592 873 QKVIDGEWPKEDNPLVNAPHTASDVTGE-WAHPYSREEAVFPLPFVREHKFWPFVNRVDDVYGDRNLVCSCPPMENYED 950
Cdd:PLN02414 909 ADIENGKADRENNVLKGAPHPPSLLMADkWDKPYSREYAAFPAPWVRASKFWPTTGRVDNVYGDRNLVCTLPSAAEEEE 987
|
|
| gcvP |
TIGR00461 |
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ... |
15-942 |
0e+00 |
|
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273089 [Multi-domain] Cd Length: 939 Bit Score: 1283.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 15 RHLSFG--DEAALLAAVGEKSMDDFVGNTVPQSIRMPSELDLPDALTEADALAKLKGIASKNMINKSYIGLGYYPTRVPN 92
Cdd:TIGR00461 1 RHLGPGetEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 93 VILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKVKSERFFVDE 172
Cdd:TIGR00461 81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSKANAFFVAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 173 RVYPQTLDVMKTRAKYFGFELVVGDFAQ-ADEGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIVAVSADIMSLVLLKP 251
Cdd:TIGR00461 161 DCHPQTIEVIKTRANPFGIEVIVGDHHTfSFSTDVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLLTP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 252 PAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKATSNICTA 331
Cdd:TIGR00461 241 PGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNICTA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 332 QALLANLAGMYAVYHGPEGVKRIAKRIHALASAFADALVSDGIKVVHKVFFDTVTVDFGSKeKTDQVFAAALESGYNLRR 411
Cdd:TIGR00461 321 QVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGEQ-SAPAILKAAEGRGINLRP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 412 VNDTQVAAAFHETSTREDLVDLYRAFTGKDTFAFA-----DDVKGRLNAELLRQNDILQHPVFNSYHTEHEMLRYLKKLE 486
Cdd:TIGR00461 400 LVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTpeelwSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQLE 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 487 DRDLAMNRSMISLGSCTMKLNATAEMLPITWAEFSDIHPYAPEAQTAGYRELLADMENSLKAITGFDAISFQPNSGAQGE 566
Cdd:TIGR00461 480 SKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQGE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 567 YSGMLSIRRYQEANGEGHRNICLIPKSAHGTNPATAAMLGLKVVVVDTDEHGNVNIDDLKAKAEQHRDALSAIMITYPST 646
Cdd:TIGR00461 560 YAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPST 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 647 HGVYEEGIRDICRIVHENGGQVYMDGANLNAQIGIMQPAKVGADVLHMNLHKTFCIPHGGGGPGMGPIGLKAHLAPFAPG 726
Cdd:TIGR00461 640 HGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLPR 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 727 HTLTDT---HSASADQTAVAAAAYGSASILPITWMYLTMMGKQGMEQATRWALLNANYVAKRLGEDYPILYTGKNGRVAH 803
Cdd:TIGR00461 720 HSLNSTaelQGEDQSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELVAH 799
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 804 ECIVDLRPLKAESGITETDIAKRLMDYGFHAPTVSFPVAGTLMIEPTESESKAELDRFIAALKSIRREVQKVIDGEWPKE 883
Cdd:TIGR00461 800 ECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEIDPA 879
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 884 DNPLVNAPHTASD-VTGEWAHPYSREEAVFPLPFVREHKFWPFVNRVDDVYGDRNLVCSC 942
Cdd:TIGR00461 880 DNPLKNAPHTAQSlICGEWNHPYSREEAAYPAPWTKQFKFWPTVGRLDDTYGDRNLVCSC 939
|
|
| GcvP2 |
COG1003 |
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ... |
446-939 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440627 Cd Length: 468 Bit Score: 746.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 446 ADDVKGRLNAELLRQNdilqhPVFNSYHTEHEMLRYLKKLEDRDLAMNRSMISLGSCTMKLNATAEMLPITWAEFSDIHP 525
Cdd:COG1003 7 EADAASLLPEALLRKS-----PVFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 526 YAPEAQTAGYRELLADMENSLKAITGFDAISFQPNSGAQGEYSGMLSIRRYQEANGEGHRNICLIPKSAHGTNPATAAML 605
Cdd:COG1003 82 FQPEETVQGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 606 GLKVVVVDTDEHGNVNIDDLKAKAeqhRDALSAIMITYPSTHGVYEEGIRDICRIVHENGGQVYMDGANLNAQIGIMQPA 685
Cdd:COG1003 162 GFKVVVVKSDEDGNVDLEDLKAKV---GDRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 686 KVGADVLHMNLHKTFCIphggggpgmgpigLKAHLAPFAPGHTLTDTHSASADQTAVAAAA------YGSASILPITWMY 759
Cdd:COG1003 239 DMGFDVCHLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVVKDGDKYRLDYDRPKSIgrsaafYGNAGVLVRAYAY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 760 LTMMGKQGMEQATRWALLNANYVAKRLGEDYPILYTGkNGRVAHECIVDLRPLKAESGITETDIAKRLMDYGFHAPTVSF 839
Cdd:COG1003 319 IRMMGAEGLREATEVAVLNANYLAARLKDHYPVLYTG-NGRCAHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYF 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 840 P--VAGTLMIEPTESESKAELDRFIAALKSIRREVQkvidgewpKEDNPLVNAPHTASdvtgewahpysreeavfplpfv 917
Cdd:COG1003 398 PliVPETLMIEPTESESKEELDRFIDAMIAIREEAR--------EDPEPLKNAPHTTP---------------------- 447
|
490 500
....*....|....*....|..
gi 488158592 918 rehkfwpfVNRVDDVYGDRNLV 939
Cdd:COG1003 448 --------VRRLDEVYADRNLV 461
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
15-437 |
0e+00 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 570.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 15 RHLSFG--DEAALLAAVGEKSMDDFVGNTVPQSIRMPSELDLPDALTEADALAKLKGIASKNMINKSYIGLGYYPTRVPN 92
Cdd:pfam02347 2 RHIGPSekDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILPP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 93 VILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKVKSERFFVDE 172
Cdd:pfam02347 82 VILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKGKKFVVDK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 173 RVYPQTLDVMKTRAKYFGFELVVGDFAQ---ADEGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIVAVSADIMSLVLL 249
Cdd:pfam02347 162 DVHPQTLEVLKTRAKPFGIEIVEVDYTEegvTDLKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 250 KPPAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKATSNIC 329
Cdd:pfam02347 242 KPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNIC 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 330 TAQALLANLAGMYAVYHGPEGVKRIAKRIHALASAFADALVSDGIKVVHKVFFDTVTVDFGSKeKTDQVFAAALESGYNL 409
Cdd:pfam02347 322 TAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEDK-AVEEVLARAEARGINL 400
|
410 420
....*....|....*....|....*...
gi 488158592 410 RRVNDTQVAAAFHETSTREDLVDLYRAF 437
Cdd:pfam02347 401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
60-437 |
4.24e-131 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 400.45 E-value: 4.24e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 60 EADALAKLKGIASKNM---INKSYIGLGYYPTRVPNVILRNVLENpGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGF 136
Cdd:cd00613 1 ETEVLRHLKRLASKNKaldQSMSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 137 PVAGASLLDEATAAAEAMAMAHRVGKVKSERFFVDERVYPQTLDVMKTRAKYFGFELVVGD-----------FAQADEGE 205
Cdd:cd00613 80 DVANASLQDEATAAAEAAGLAAIRAYHKRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPsdeggtvdleaLKEEVSEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 206 YFGALFQYVGKDGDVQDLQDVIGRL-KAKGTIVAVSADIMSLVLLKPPAELGADIALGNTQRFGVPMGFGGPHAAYFAFK 284
Cdd:cd00613 160 VAALMVQYPNTLGVFEDLIKEIADIaHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 285 DAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKATSNICTAQALLANLAGMYAVYHGPEGVKRIAKRIHALASA 364
Cdd:cd00613 240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 365 FADALVSDG-IKVVHKVFFDTVTVDFGSK-EKTDQVFAAALESGYNLRR-----VNDTqVAAAFHETSTREDLVDLYRAF 437
Cdd:cd00613 320 LAKRLKEVGgVLPFNGPFFHEFVLRLPPLyGIRAEDLAKALIDGGFHAPtmylpVDGT-LMIEPTETETKEELDALLEAL 398
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02414 |
PLN02414 |
glycine dehydrogenase (decarboxylating) |
10-950 |
0e+00 |
|
glycine dehydrogenase (decarboxylating)
Pssm-ID: 178035 [Multi-domain] Cd Length: 993 Bit Score: 1329.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 10 DEFAARHLSFG--DEAALLAAVGEKSMDDFVGNTVPQSIRMPSeLDLP---DALTEADALAKLKGIASKNMINKSYIGLG 84
Cdd:PLN02414 33 DTFPRRHNSATpeEQKAMAEYCGFDSLDALIDATVPKSIRLDS-MKLSkydEGLTESQMLEHMKSLASKNKVFKSYIGMG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 85 YYPTRVPNVILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKVK 164
Cdd:PLN02414 112 YYNTHVPPVILRNILENPGWYTQYTPYQAEIAQGRLESLLNYQTMITDLTGLPMSNASLLDEGTAAAEAMAMCNNILKGK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 165 SERFFVDERVYPQTLDVMKTRAKYFGFELVVGDFAQAD--EGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIVAVSAD 242
Cdd:PLN02414 192 KKKFLIASNCHPQTIDVCQTRADGLGLEVVVADEKDFDysSGDVCGVLVQYPATDGEVLDYAEFVKNAHANGVKVVMATD 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 243 IMSLVLLKPPAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRRE 322
Cdd:PLN02414 272 LLALTMLKPPGEWGADIVVGSAQRFGVPMGYGGPHAAFLATSQEYKRLMPGRIIGVSVDSSGKPALRMAMQTREQHIRRD 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 323 KATSNICTAQALLANLAGMYAVYHGPEGVKRIAKRIHALASAFADALVSDGIKVVHKVFFDTVTVDFGSKektDQVFAAA 402
Cdd:PLN02414 352 KATSNICTAQALLANMAAMYAVYHGPEGLKTIAQRVHGLAGVFAAGLKKLGFQVQSLPFFDTVKVKCSDA---DAIADAA 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 403 LESGYNLRRVNDTQVAAAFHETSTREDLVDLYRAFTGKDTFAF-----ADDVKGRLNAELLRQNDILQHPVFNSYHTEHE 477
Cdd:PLN02414 429 AKVGINLRVVDANTVTVSFDETTTLEDVDKLFKVFAGGKPVPFtaeslAPEVDSSIPSSLARESPYLTHPIFNQYHSEHE 508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 478 MLRYLKKLEDRDLAMNRSMISLGSCTMKLNATAEMLPITWAEFSDIHPYAPEAQTAGYRELLADMENSLKAITGFDAISF 557
Cdd:PLN02414 509 LLRYLHRLQNKDLSLVHSMIPLGSCTMKLNATTEMMPVTWPEFANIHPFAPVDQAQGYQEMFEDLGDLLCEITGFDSFSL 588
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 558 QPNSGAQGEYSGMLSIRRYQEANGEGHRNICLIPKSAHGTNPATAAMLGLKVVVVDTDEHGNVNIDDLKAKAEQHRDALS 637
Cdd:PLN02414 589 QPNAGAAGEYAGLMVIRAYHLSRGDHHRNVCIIPVSAHGTNPASAAMCGMKIVVVGTDAKGNINIEELRKAAEAHKDNLA 668
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 638 AIMITYPSTHGVYEEGIRDICRIVHENGGQVYMDGANLNAQIGIMQPAKVGADVLHMNLHKTFCIPHGGGGPGMGPIGLK 717
Cdd:PLN02414 669 ALMVTYPSTHGVYEEGIDEICDIIHDNGGQVYMDGANMNAQVGLTSPGFIGADVCHLNLHKTFCIPHGGGGPGMGPIGVK 748
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 718 AHLAPFAPGHTLTDTHSASA-DQT----AVAAAAYGSASILPITWMYLTMMGKQGMEQATRWALLNANYVAKRLGEDYPI 792
Cdd:PLN02414 749 KHLAPFLPSHPVVPTGGIPRpEKTqplgTISAAPWGSALILPISYTYIAMMGSEGLTDASKIAILNANYMAKRLEGHYPV 828
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 793 LYTGKNGRVAHECIVDLRPLKAESGITETDIAKRLMDYGFHAPTVSFPVAGTLMIEPTESESKAELDRFIAALKSIRREV 872
Cdd:PLN02414 829 LFRGKNGTCAHEFIIDLRPFKNTAGIEPEDVAKRLMDYGFHAPTMSWPVPGTLMIEPTESESKAELDRFCDALISIREEI 908
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488158592 873 QKVIDGEWPKEDNPLVNAPHTASDVTGE-WAHPYSREEAVFPLPFVREHKFWPFVNRVDDVYGDRNLVCSCPPMENYED 950
Cdd:PLN02414 909 ADIENGKADRENNVLKGAPHPPSLLMADkWDKPYSREYAAFPAPWVRASKFWPTTGRVDNVYGDRNLVCTLPSAAEEEE 987
|
|
| gcvP |
TIGR00461 |
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in ... |
15-942 |
0e+00 |
|
glycine dehydrogenase (decarboxylating); This apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment. [Energy metabolism, Amino acids and amines]
Pssm-ID: 273089 [Multi-domain] Cd Length: 939 Bit Score: 1283.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 15 RHLSFG--DEAALLAAVGEKSMDDFVGNTVPQSIRMPSELDLPDALTEADALAKLKGIASKNMINKSYIGLGYYPTRVPN 92
Cdd:TIGR00461 1 RHLGPGetEQRQMLQTLGFDTLNALIDQAVPPAIRFPRPLQLPAPQSEYGALAQLKSIASKNQVFRSYIGMGYYDTILPP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 93 VILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKVKSERFFVDE 172
Cdd:TIGR00461 81 VIQRNILENPGWYTAYTPYQPEISQGRLEALLNFQTVVMDLTGLEIANASLLDEGTAAAEAMALSYGVSKSKANAFFVAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 173 RVYPQTLDVMKTRAKYFGFELVVGDFAQ-ADEGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIVAVSADIMSLVLLKP 251
Cdd:TIGR00461 161 DCHPQTIEVIKTRANPFGIEVIVGDHHTfSFSTDVFGALLQYPATDGAIYDYRSLIDKLHSHKALVSVAADPMALTLLTP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 252 PAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKATSNICTA 331
Cdd:TIGR00461 241 PGELGADIVVGSTQRFGVPMGYGGPHAAFFATKDEYQRKMPGRIVGVSKDAHGNTALRLALQTREQHIRRDKATSNICTA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 332 QALLANLAGMYAVYHGPEGVKRIAKRIHALASAFADALVSDGIKVVHKVFFDTVTVDFGSKeKTDQVFAAALESGYNLRR 411
Cdd:TIGR00461 321 QVLLANMASMYGVYHGPTGLKNIALRIHQLTVILAIGLKRLNYSLNNDYFFDTLRVGVGEQ-SAPAILKAAEGRGINLRP 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 412 VNDTQVAAAFHETSTREDLVDLYRAFTGKDTFAFA-----DDVKGRLNAELLRQNDILQHPVFNSYHTEHEMLRYLKKLE 486
Cdd:TIGR00461 400 LVPGEVGISLDETTTVQDVLDLWQVFAGKDNLPFTpeelwSDVKTSFPADLTRQDEILQDAVFNQYHSETEMLRYLHQLE 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 487 DRDLAMNRSMISLGSCTMKLNATAEMLPITWAEFSDIHPYAPEAQTAGYRELLADMENSLKAITGFDAISFQPNSGAQGE 566
Cdd:TIGR00461 480 SKDLALNTSMIPLGSCTMKLNATAEMMPITWPEFGKIHPFAPAGQTEGYQILIAQLEAWLGEITGFDAISLQPNSGAQGE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 567 YSGMLSIRRYQEANGEGHRNICLIPKSAHGTNPATAAMLGLKVVVVDTDEHGNVNIDDLKAKAEQHRDALSAIMITYPST 646
Cdd:TIGR00461 560 YAGLQVIRQYHESRGEEHRNICLIPESAHGTNPASAVMAGMQVVPVKCDGEGNIDLEDLTSKAEQYGDRLAALMVTYPST 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 647 HGVYEEGIRDICRIVHENGGQVYMDGANLNAQIGIMQPAKVGADVLHMNLHKTFCIPHGGGGPGMGPIGLKAHLAPFAPG 726
Cdd:TIGR00461 640 HGVFEATIGTICDIVHRFGGQVYLDGANMNAQVGLTSPGDFGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQPFLPR 719
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 727 HTLTDT---HSASADQTAVAAAAYGSASILPITWMYLTMMGKQGMEQATRWALLNANYVAKRLGEDYPILYTGKNGRVAH 803
Cdd:TIGR00461 720 HSLNSTaelQGEDQSIGMVSAAPYGSASILPISWMYIAMMGPEGLTKASEVAILNANYMAKRLEDYYPILFRGNNELVAH 799
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 804 ECIVDLRPLKAESGITETDIAKRLMDYGFHAPTVSFPVAGTLMIEPTESESKAELDRFIAALKSIRREVQKVIDGEWPKE 883
Cdd:TIGR00461 800 ECILDLRPLKKQAGIEVEDVAKRLMDYGFHAPTVSFPVLGTLMVEPTESESLGELDRFCDAMIAIYQEIQAITAGEIDPA 879
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 884 DNPLVNAPHTASD-VTGEWAHPYSREEAVFPLPFVREHKFWPFVNRVDDVYGDRNLVCSC 942
Cdd:TIGR00461 880 DNPLKNAPHTAQSlICGEWNHPYSREEAAYPAPWTKQFKFWPTVGRLDDTYGDRNLVCSC 939
|
|
| GcvP2 |
COG1003 |
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport ... |
446-939 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440627 Cd Length: 468 Bit Score: 746.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 446 ADDVKGRLNAELLRQNdilqhPVFNSYHTEHEMLRYLKKLEDRDLAMNRSMISLGSCTMKLNATAEMLPITWAEFSDIHP 525
Cdd:COG1003 7 EADAASLLPEALLRKS-----PVFLPEVSETEVLRHYTRLSQKNLGLDTGMIPLGSCTMKYNPKINEEPATLPGFANLHP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 526 YAPEAQTAGYRELLADMENSLKAITGFDAISFQPNSGAQGEYSGMLSIRRYQEANGEGHRNICLIPKSAHGTNPATAAML 605
Cdd:COG1003 82 FQPEETVQGYLELMYELEEWLAEITGMDAVSLQPNAGAQGEYAGLLAIRAYHESRGEGHRNEILIPDSAHGTNPASAAMA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 606 GLKVVVVDTDEHGNVNIDDLKAKAeqhRDALSAIMITYPSTHGVYEEGIRDICRIVHENGGQVYMDGANLNAQIGIMQPA 685
Cdd:COG1003 162 GFKVVVVKSDEDGNVDLEDLKAKV---GDRTAALMLTNPSTHGVFEEDIKEICDIVHEAGGLVYYDGANLNAIVGLARPG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 686 KVGADVLHMNLHKTFCIphggggpgmgpigLKAHLAPFAPGHTLTDTHSASADQTAVAAAA------YGSASILPITWMY 759
Cdd:COG1003 239 DMGFDVCHLNLHKTFSTphggggpgsgpvgVKEHLAPFLPGPPVVKDGDKYRLDYDRPKSIgrsaafYGNAGVLVRAYAY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 760 LTMMGKQGMEQATRWALLNANYVAKRLGEDYPILYTGkNGRVAHECIVDLRPLKAESGITETDIAKRLMDYGFHAPTVSF 839
Cdd:COG1003 319 IRMMGAEGLREATEVAVLNANYLAARLKDHYPVLYTG-NGRCAHEFILDLRPLKKETGVTTLDIAKRLLDYGFHAPTMYF 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 840 P--VAGTLMIEPTESESKAELDRFIAALKSIRREVQkvidgewpKEDNPLVNAPHTASdvtgewahpysreeavfplpfv 917
Cdd:COG1003 398 PliVPETLMIEPTESESKEELDRFIDAMIAIREEAR--------EDPEPLKNAPHTTP---------------------- 447
|
490 500
....*....|....*....|..
gi 488158592 918 rehkfwpfVNRVDDVYGDRNLV 939
Cdd:COG1003 448 --------VRRLDEVYADRNLV 461
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
10-439 |
0e+00 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 600.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 10 DEFAARHL--SFGDEAALLAAVGEKSMDDFVgNTVPQSIRMPSELDLPDALTEADALAKLKGIASKNMINKSYIGLGYYP 87
Cdd:COG0403 1 DEFAMRYIppTEEDRAEMLAAIGVDSLDELF-DDIPAEIRLKRPLDLPEALSEAELLRHLRALAAKNKVLTSFIGAGYYD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 88 TRVPNVIlRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKvKSER 167
Cdd:COG0403 80 HYVPAVV-RNILERPEFYTAYTPYQPEISQGRLQALFEFQTMVAELTGMDVANASLYDGATAAAEAMLMARRVTK-RSNK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 168 FFVDERVYPQTLDVMKTRAKYFGFELV----------VGDFAQADEGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIV 237
Cdd:COG0403 158 VLVSEDVHPQTRAVLKTYAEPLGIEVVevpdedgvtdLEALKALLDDDVAGVLVQYPNFFGVIEDLRAIAEAAHAAGALV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 238 AVSADIMSLVLLKPPAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDAFKRSAPGRIIGVSKDASGKPALRMALSTREQ 317
Cdd:COG0403 238 IVAADPLSLGLLKPPGELGADIVVGEGQRLGVPLGFGGPHAGFFATREKLVRQMPGRLVGVTVDADGKRAFRLTLQTREQ 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 318 HIRREKATSNICTAQALLANLAGMYAVYHGPEGVKRIAKRIHALASAFADALVSDGIKVV-HKVFFDTVTVDFGskEKTD 396
Cdd:COG0403 318 HIRREKATSNICTNQALLALAASMYAVYHGPEGLKEIAERIHQKAHYLAERLAALGVEVPfNGPFFDEFVVRLP--KPAA 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 488158592 397 QVFAAALE----SGYNLRRVNDTQVAAAFHETSTREDLVDLYRAFTG 439
Cdd:COG0403 396 EINAALLEkgilGGLNLRRVDDDTLLVAVTETTTKEDIDALVEALAE 442
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
15-437 |
0e+00 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 570.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 15 RHLSFG--DEAALLAAVGEKSMDDFVGNTVPQSIRMPSELDLPDALTEADALAKLKGIASKNMINKSYIGLGYYPTRVPN 92
Cdd:pfam02347 2 RHIGPSekDQQEMLATLGYSSLDDLIGKAVPKNIRFAKPLQLPAPKSEYEALAELEAIASKNTVYRSFIGMGYYDTILPP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 93 VILRNVLENPGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGFPVAGASLLDEATAAAEAMAMAHRVGKVKSERFFVDE 172
Cdd:pfam02347 82 VILRNILENPEWYTAYTPYQPEISQGRLEALLNFQTMICDLTGLDIANASLLDEGTAAAEAMALAARASKKKGKKFVVDK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 173 RVYPQTLDVMKTRAKYFGFELVVGDFAQ---ADEGEYFGALFQYVGKDGDVQDLQDVIGRLKAKGTIVAVSADIMSLVLL 249
Cdd:pfam02347 162 DVHPQTLEVLKTRAKPFGIEIVEVDYTEegvTDLKDVFGVLVQYPNTDGRIEDYKELIELAHQRKSLVVVAADLLALTLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 250 KPPAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKATSNIC 329
Cdd:pfam02347 242 KPPGEFGADIAVGSAQRFGVPLGYGGPHAGFFAVKKELVRKMPGRLVGVSKDANGKRALRLALQTREQHIRRDKATSNIC 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 330 TAQALLANLAGMYAVYHGPEGVKRIAKRIHALASAFADALVSDGIKVVHKVFFDTVTVDFGSKeKTDQVFAAALESGYNL 409
Cdd:pfam02347 322 TAQALLANMASMYAVYHGPNGLKEIARRIHSLTLYLAKALKKLGHELVHKHFFDTLLIEVEDK-AVEEVLARAEARGINL 400
|
410 420
....*....|....*....|....*...
gi 488158592 410 RRVNDTQVAAAFHETSTREDLVDLYRAF 437
Cdd:pfam02347 401 RYVDLGHVGIALDETVTKEDIDDLLQVF 428
|
|
| PRK04366 |
PRK04366 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPB; |
496-895 |
2.76e-135 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
Pssm-ID: 235292 Cd Length: 481 Bit Score: 414.12 E-value: 2.76e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 496 MISLGSCTMK----LNATAEMLPitwaEFSDIHPYAPEAQTAGYRELLADMENSLKAITGFDAISFQPNSGAQGEYSGML 571
Cdd:PRK04366 72 FYPLGSCTMKynpkINEKVARLP----GFAELHPLQPEETVQGALELMYELQEWLKEITGMDAVTLQPAAGAHGELTGLL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 572 SIRRYQEANGEGHRNICLIPKSAHGTNPATAAMLGLKVVVVDTDEHGNVNIDDLKAkaeqhrdALS----AIMITYPSTH 647
Cdd:PRK04366 148 MIRAYHEARGDTKRTEVIVPDSAHGTNPASAAMAGFKVVEIPSNEDGLVDLEALKA-------AVGedtaALMLTNPNTL 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 648 GVYEEGIRDICRIVHENGGQVYMDGANLNAQIGIMQPAKVGADVLHMNLHKTF--------------Ciphggggpgmgp 713
Cdd:PRK04366 221 GLFERNILEIAEIVHEAGGLLYYDGANLNAILGKARPGDMGFDVVHLNLHKTFstphggggpgsgpvG------------ 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 714 igLKAHLAPFAP---------GHTLTDTHSASADQTavaAAAYGSASILPITWMYLTMMGKQGMEQATRWALLNANYVAK 784
Cdd:PRK04366 289 --VKEELAPFLPvpvvekdgdRYRLDYDRPKSIGRV---RAFYGNFGVLVRAYAYIRSLGAEGLREVSEDAVLNANYLKA 363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 785 RLGEDYPILYtgkNGRVAHECIVDLRPLKaESGITETDIAKRLMDYGFHAPTVSFP--VAGTLMIEPTESESKAELDRFI 862
Cdd:PRK04366 364 RLKDIYDLPY---DRPCMHEFVLSGKKLK-ETGVRTLDIAKRLLDYGFHPPTIYFPliVPEALMIEPTETESKETLDAFI 439
|
410 420 430
....*....|....*....|....*....|....*
gi 488158592 863 AALKSIRREVqkvidgewpkEDNP--LVNAPHTAS 895
Cdd:PRK04366 440 AAMKQIAEEA----------KENPelVKEAPHNTP 464
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
60-437 |
4.24e-131 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 400.45 E-value: 4.24e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 60 EADALAKLKGIASKNM---INKSYIGLGYYPTRVPNVILRNVLENpGWYTAYTPYQAEIAQGRLEALLNFQQVCIDLTGF 136
Cdd:cd00613 1 ETEVLRHLKRLASKNKaldQSMSFLGSGTYKHNPPAVIKRNILEN-EFYTAYTPYQPEISQGRLQALFELQTMLCELTGM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 137 PVAGASLLDEATAAAEAMAMAHRVGKVKSERFFVDERVYPQTLDVMKTRAKYFGFELVVGD-----------FAQADEGE 205
Cdd:cd00613 80 DVANASLQDEATAAAEAAGLAAIRAYHKRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPsdeggtvdleaLKEEVSEE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 206 YFGALFQYVGKDGDVQDLQDVIGRL-KAKGTIVAVSADIMSLVLLKPPAELGADIALGNTQRFGVPMGFGGPHAAYFAFK 284
Cdd:cd00613 160 VAALMVQYPNTLGVFEDLIKEIADIaHSAGALVYVDGDNLNLTGLKPPGEYGADIVVGNLQKTGVPHGGGGPGAGFFAVK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 285 DAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKATSNICTAQALLANLAGMYAVYHGPEGVKRIAKRIHALASA 364
Cdd:cd00613 240 KELVRFLPGRLVGVTKDAEGNRAFRLALQTREQHIRREKATSNICTGQALLALMAAMYIVYLGPEGLKEIAERAHLNANY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 365 FADALVSDG-IKVVHKVFFDTVTVDFGSK-EKTDQVFAAALESGYNLRR-----VNDTqVAAAFHETSTREDLVDLYRAF 437
Cdd:cd00613 320 LAKRLKEVGgVLPFNGPFFHEFVLRLPPLyGIRAEDLAKALIDGGFHAPtmylpVDGT-LMIEPTETETKEELDALLEAL 398
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
475-865 |
4.92e-131 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 400.07 E-value: 4.92e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 475 EHEMLRYLKKLEDRDLAMNRSMISLGSCTMKLNATAEMLPITW-AEFSDIHPYAPEAQTAGYRELLADMENSLKAITGFD 553
Cdd:cd00613 1 ETEVLRHLKRLASKNKALDQSMSFLGSGTYKHNPPAVIKRNILeNEFYTAYTPYQPEISQGRLQALFELQTMLCELTGMD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 554 --AISFQPNSGAQGEYSGMLSIRRYqeangeGHRNICLIPKSAHGTNPATAAM----LGLKVVVVDTDEHGNVnidDLKA 627
Cdd:cd00613 81 vaNASLQDEATAAAEAAGLAAIRAY------HKRNKVLVPDSAHPTNPAVARTrgepLGIEVVEVPSDEGGTV---DLEA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 628 KAEQHRDALSAIMITYPSTHGVYEEGIRDICRIVHENGGQVYMDGANLNAQiGIMQPAKVGADVLHMNLHKTF------- 700
Cdd:cd00613 152 LKEEVSEEVAALMVQYPNTLGVFEDLIKEIADIAHSAGALVYVDGDNLNLT-GLKPPGEYGADIVVGNLQKTGvphgggg 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 701 -------CiphggggpgmgpiglKAHLAPFAPGH--------------TLT----DTHSASADQTavAAAAYGSASILPI 755
Cdd:cd00613 231 pgagffaV---------------KKELVRFLPGRlvgvtkdaegnrafRLAlqtrEQHIRREKAT--SNICTGQALLALM 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 756 TWMYLTMMGKQGMEQATRWALLNANYVAKRLGEDYPILytGKNGRVAHECIVDLRPLkaeSGITETDIAKRLMDYGFHAP 835
Cdd:cd00613 294 AAMYIVYLGPEGLKEIAERAHLNANYLAKRLKEVGGVL--PFNGPFFHEFVLRLPPL---YGIRAEDLAKALIDGGFHAP 368
|
410 420 430
....*....|....*....|....*....|
gi 488158592 836 TVSFPVAGTLMIEPTESESKAELDRFIAAL 865
Cdd:cd00613 369 TMYLPVDGTLMIEPTETETKEELDALLEAL 398
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
21-430 |
4.46e-101 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 323.24 E-value: 4.46e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 21 DEAALLAAVGEKSMDDFVGNtVPQSIRMPSELDLPDALTEADALAKLKGIASKNMINK---SYIGLGYYPTRVPNVIlRN 97
Cdd:PRK00451 11 DIREMLDAIGVKSIDELFAD-IPEELRLKRPLDLPPGLSEMELLRHLRELAAKNKTAEeypSFLGAGAYDHYIPAVV-DH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 98 VLENPGWYTAYTPYQAEIAQGRLEALLNFQ-QVCiDLTGFPVAGASLLDEATAAAEAMAMAHRVgkVKSERFFVDERVYP 176
Cdd:PRK00451 89 IISRSEFYTAYTPYQPEISQGTLQAIFEYQtMIC-ELTGMDVANASMYDGATALAEAALMAVRI--TKRKKVLVSGAVHP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 177 QTLDVMKTRAKYFGFELVVGDFAqaDEGEYFGALFQYVGKD------------GDVQDLQDVIGRLKAKGTIVAVSADIM 244
Cdd:PRK00451 166 EYREVLKTYLKGQGIEVVEVPYE--DGVTDLEALEAAVDDDtaavvvqypnffGVIEDLEEIAEIAHAGGALFIVGVDPV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 245 SLVLLKPPAELGADIALGNTQRFGVPMGFGGPHAAYFAFKDAFKRSAPGRIIGVSKDASGKPALRMALSTREQHIRREKA 324
Cdd:PRK00451 244 SLGLLKPPGEYGADIVVGEGQPLGIPLSFGGPYLGFFATRKKLVRQMPGRLVGETVDADGKRGFVLTLQAREQHIRREKA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 325 TSNICTAQALLANLAGMYAVYHGPEGVKRIAKRIHALASAFADALVS-DGIKVVHKVFFDTVTVDFgsKEKTDQVFAAAL 403
Cdd:PRK00451 324 TSNICTNQALNALAAAIYMSLLGPEGLRELAEQNHQKAHYLAERLAEiGGVELFDGPFFNEFVVRL--PKPAEEVNEALL 401
|
410 420 430
....*....|....*....|....*....|....*.
gi 488158592 404 E----SGYNLRRV-----NDTQVAAAfhETSTREDL 430
Cdd:PRK00451 402 EkgilGGYDLGRYypelgNHLLVCVT--EKRTKEDI 435
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
536-701 |
2.99e-10 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 60.09 E-value: 2.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 536 RELLADMENslkaiTGFDAISFQPnSGAQGEYSGMLSIRRYQE---ANGEGHrniclipksaHGTNPATAAMLGLKVVVV 612
Cdd:cd01494 6 EEKLARLLQ-----PGNDKAVFVP-SGTGANEAALLALLGPGDeviVDANGH----------GSRYWVAAELAGAKPVPV 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 613 DTDEHGNVNIDDLKAKAEQHRDALSAIMITYPSTHGVYEEGIRDICRIVHENGGQVYMDGANLN-AQIGIMQPAKVG-AD 690
Cdd:cd01494 70 PVDDAGYGGLDVAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGgASPAPGVLIPEGgAD 149
|
170
....*....|.
gi 488158592 691 VLHMNLHKTFC 701
Cdd:cd01494 150 VVTFSLHKNLG 160
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
589-868 |
1.18e-07 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 55.14 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 589 LIPKSAHgtnPATAAML-------GLKVVVVDTDEhGNVNIDDLKAKAEqhrDALSAIMITYPSTHGVYEEgIRDICRIV 661
Cdd:PRK00451 158 LVSGAVH---PEYREVLktylkgqGIEVVEVPYED-GVTDLEALEAAVD---DDTAAVVVQYPNFFGVIED-LEEIAEIA 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 662 HENGGQVYMdGANLNAQiGIMQ-PAKVGADV---------LHMNLHKTfciphggggpgmgpiglkaHLAPFA------- 724
Cdd:PRK00451 230 HAGGALFIV-GVDPVSL-GLLKpPGEYGADIvvgegqplgIPLSFGGP-------------------YLGFFAtrkklvr 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 725 ----------------PGHTLT----DTH-----------SASAdqtavaaaaygsasILPITW-MYLTMMGKQGMEQAT 772
Cdd:PRK00451 289 qmpgrlvgetvdadgkRGFVLTlqarEQHirrekatsnicTNQA--------------LNALAAaIYMSLLGPEGLRELA 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 773 RWALLNANYVAKRLGE--DYPILytgkNGRVAHECIVDLrPLKAEsgitetDIAKRLMDYGFHAPtvsFPV-------AG 843
Cdd:PRK00451 355 EQNHQKAHYLAERLAEigGVELF----DGPFFNEFVVRL-PKPAE------EVNEALLEKGILGG---YDLgryypelGN 420
|
330 340
....*....|....*....|....*
gi 488158592 844 TLMIEPTESESKAELDRFIAALKSI 868
Cdd:PRK00451 421 HLLVCVTEKRTKEDIDALVAALGEV 445
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
602-866 |
5.92e-07 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 53.11 E-value: 5.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 602 AAMLGLKVVVVDtDEHGNVNIDDLKAKAEqhrDALSAIMITYPSTHGVYEEgIRDICRIVHENGGQVYMdGANLNAQiGI 681
Cdd:COG0403 176 AEPLGIEVVEVP-DEDGVTDLEALKALLD---DDVAGVLVQYPNFFGVIED-LRAIAEAAHAAGALVIV-AADPLSL-GL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 682 MQ-PAKVGADV---------LHMNlhktfciphggggpgmgpiglkaHLAPFA---------PGH----TlTDTHSASAd 738
Cdd:COG0403 249 LKpPGELGADIvvgegqrlgVPLGfg-------------------gpHAGFFAtreklvrqmPGRlvgvT-VDADGKRA- 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 739 qtavaaaaY--------------------GSASILP--ITWMYLTMMGKQGMEQ-ATRwALLNANYVAKRLGE-DYPILY 794
Cdd:COG0403 308 --------FrltlqtreqhirrekatsniCTNQALLalAASMYAVYHGPEGLKEiAER-IHQKAHYLAERLAAlGVEVPF 378
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488158592 795 tgkNGRVAHECIVDLrPLKAEsgitetDIAKRLMDYGFHAPT-VSFPVAGTLMIEPTESESKAELDRFIAALK 866
Cdd:COG0403 379 ---NGPFFDEFVVRL-PKPAA------EINAALLEKGILGGLnLRRVDDDTLLVAVTETTTKEDIDALVEALA 441
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
542-698 |
3.18e-05 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 46.83 E-value: 3.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 542 MENSLKAITGFDAISFQPnSGAQGEYSGMLS-IRRYQEAngeghrnICLIPksAHG---TNPATAAMLGLKVVVVDTDEH 617
Cdd:pfam01212 37 LEDRVAELFGKEAALFVP-SGTAANQLALMAhCQRGDEV-------ICGEP--AHIhfdETGGHAELGGVQPRPLDGDEA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 618 GNVNIDDLKAK----AEQHRDALSAIMITypSTHG------VYEEGIRDICRIVHENGGQVYMDGANL-NAQIGIMQPAK 686
Cdd:pfam01212 107 GNMDLEDLEAAirevGADIFPPTGLISLE--NTHNsaggqvVSLENLREIAALAREHGIPVHLDGARFaNAAVALGVIVK 184
|
170
....*....|....*
gi 488158592 687 ---VGADVLHMNLHK 698
Cdd:pfam01212 185 eitSYADSVTMCLSK 199
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
508-701 |
2.38e-04 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 44.25 E-value: 2.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 508 ATAEMLPITwaefsdihpYAPEAQTAGYRE--LLADMENSLKAITGFDAISFQPnSGAQGEYSGMLSI-RRYQEAngegh 584
Cdd:cd06502 10 PTPEMLEAM---------AAANVGDDVYGEdpTTAKLEARAAELFGKEAALFVP-SGTAANQLALAAHtQPGGSV----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 585 rnICliPKSAHGTN---PATAAMLGLKVVVVDTdEHGNVNIDDLKAKAEQHRDALSAI--MITYPSTH---GVY-EEGIR 655
Cdd:cd06502 75 --IC--HETAHIYTdeaGAPEFLSGVKLLPVPG-ENGKLTPEDLEAAIRPRDDIHFPPpsLVSLENTTeggTVYpLDELK 149
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 488158592 656 DICRIVHENGGQVYMDGANL-NAQIGIMQPAK---VGADVLHMNLHKTFC 701
Cdd:cd06502 150 AISALAKENGLPLHLDGARLaNAAAALGVALKtykSGVDSVSFCLSKGGG 199
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
573-673 |
2.80e-03 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 41.03 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488158592 573 IRRYQEANGEG-HRNICLIPKSAHGTNPATAAMLGLKVVVVDTDEHGNVNIDDLKAK-AEQHRDALSAIMI--TYPST-H 647
Cdd:cd06450 82 RKRLKAGGGRGiDKLVIVCSDQAHVSVEKAAAYLDVKVRLVPVDEDGRMDPEALEAAiDEDKAEGLNPIMVvaTAGTTdT 161
|
90 100
....*....|....*....|....*.
gi 488158592 648 GVYEEgIRDICRIVHENGGQVYMDGA 673
Cdd:cd06450 162 GAIDP-LEEIADLAEKYDLWLHVDAA 186
|
|
| |
