NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|488215578|ref|WP_002286786|]
View 

MULTISPECIES: carbohydrate ABC transporter permease [Enterococcus]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 6-284 7.22e-104

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 303.94  E-value: 7.22e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578   6 KKTSVNRQTKKILSYVLMTVIGIILIIPLLWMVFTSLKPMEEIVRYPPTFFPEKIVWENYLDTIAAFPFWRYARNTLFIT 85
Cdd:COG0395    4 TARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  86 VLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGWVGTYLPLIVPS-FFGNAFNIFLM 164
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYlAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 165 RQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQEKYTLQIGLQVFQNQAT 244
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 488215578 245 TQWNYLMAGATLVLIPTILLFFFAQRYFIEGMdLTGGSKG 284
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGL-TAGAVKG 282
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 6-284 7.22e-104

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 303.94  E-value: 7.22e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578   6 KKTSVNRQTKKILSYVLMTVIGIILIIPLLWMVFTSLKPMEEIVRYPPTFFPEKIVWENYLDTIAAFPFWRYARNTLFIT 85
Cdd:COG0395    4 TARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  86 VLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGWVGTYLPLIVPS-FFGNAFNIFLM 164
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYlAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 165 RQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQEKYTLQIGLQVFQNQAT 244
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 488215578 245 TQWNYLMAGATLVLIPTILLFFFAQRYFIEGMdLTGGSKG 284
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGL-TAGAVKG 282
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
46-276 2.03e-29

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 112.52  E-value: 2.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  46 EEIVRYPPTFFPEKIVWENyLDTI-------AAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALV 118
Cdd:PRK10973  39 QAVFAVPMTLIPGTHLLEN-IANIwvngvgnNSAPFGRMLLNSFVMAFSITVGKITVSMLSAFAIVWFRFPLRNLFFWMI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 119 LSTMMIPGFVTMIPQYVLFSKIGWVGTYLPLIVPsFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLT 198
Cdd:PRK10973 118 FITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLP-LMASATATFLFRQFFMTLPDELVEAARIDGASPMRFFWDIVLPLS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 199 KPALITIAINSFNAAWNDFLGPLLYIQDQEKYTLQIGLQ--VFQNQATTQWNYLMAGATLVLIPTILLFFFAQRYFIEGM 276
Cdd:PRK10973 197 KTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKgmIATGEGTTEWNQVMAAMLLTLIPPVVIVLAMQRAFVRGL 276
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 78-262 2.93e-20

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 85.79  E-value: 2.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  78 ARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGWVG-----TYLPLIVP 152
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGilpglGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 153 SFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQEKYTL 232
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 488215578 233 QIGLQVFQNQATTQWNYLMAGATLVLIPTI 262
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 108-272 1.08e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 62.32  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  108 FPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGWVGTYLPLIVPSFFGNAFNIFLMRQFYL-SINNELIEAAEIDGANH 186
Cdd:pfam00528  14 RRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALrSLPSDLVEAARALGASR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  187 LYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQEKYTLQIglQVFQNQATTQWNYLMAGATLVLIPTILLFF 266
Cdd:pfam00528  94 WQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLI--EAILGYDYPEIQGPVLAAALILLLLNLLVD 171


                  ....*.
gi 488215578  267 FAQRYF 272
Cdd:pfam00528 172 ILQRLL 177
permease_CysT TIGR02139
sulfate ABC transporter, permease protein CysT; This model represents CysT, one of two ...
 62-204 5.15e-05

sulfate ABC transporter, permease protein CysT; This model represents CysT, one of two homologous, tandem permeases in the sulfate ABC transporter system; the other is CysW (TIGR02140). The sulfate transporter has been described in E. coli as transporting sulfate, thiosulfate, selenate, and selenite. Sulfate transporters may also transport molybdate ion if a specific molybdate transporter is not present. [Transport and binding proteins, Anions]


Pssm-ID: 131194  Cd Length: 265  Bit Score: 43.85  E-value: 5.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578   62 WENYLDTIAAfPFWRYARNTLFITVLVV-IGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKI 140
Cdd:TIGR02139  36 WAGFWQIITE-PRVLAAYKLSFGTALIAaLINAVFGTLLAWVLVRYRFPGKRIVDALVDLPFALPTAVAGIALATLYSPN 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488215578  141 GWVGTYLP-------------LIVPSFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALIT 204
Cdd:TIGR02139 115 GWIGSFLAplgikiaftplgiVIALVFVSLPFVVRTVQPVLEEIEKELEEAAASLGASRWQTFWRVILPALLPALLT 191
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 6-284 7.22e-104

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 303.94  E-value: 7.22e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578   6 KKTSVNRQTKKILSYVLMTVIGIILIIPLLWMVFTSLKPMEEIVRYPPTFFPEKIVWENYLDTIAAFPFWRYARNTLFIT 85
Cdd:COG0395    4 TARRRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  86 VLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGWVGTYLPLIVPS-FFGNAFNIFLM 164
Cdd:COG0395   84 VVSTVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYlAFGLPFGIFLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 165 RQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQEKYTLQIGLQVFQNQAT 244
Cdd:COG0395  164 RQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 488215578 245 TQWNYLMAGATLVLIPTILLFFFAQRYFIEGMdLTGGSKG 284
Cdd:COG0395  244 TDWGLLMAAAVIATLPVLILFLFLQRYFVRGL-TAGAVKG 282
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 2-284 2.24e-62

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 198.07  E-value: 2.24e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578   2 MDYFKKTSVNRQTKKILSYVLMTVIGIILIIPLLWMVFTSLKPMEEIvrYPPTFFPEKIVWENYLDTIAAFPFWRYARNT 81
Cdd:COG3833    1 MSRRKSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSL--YSSSLIPENFTLENYKKLFTETPFLRWFLNS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  82 LFITVLVVIGNVLSNSFIAYGFAKLDFPGKK--LMFALVLstMMIPGFVTMIPQYVLFSKIGWVGTYLPLIVPSFFGN-A 158
Cdd:COG3833   79 LIVAVVTAIISVFLAALAAYAFSRFRFKGRKagLLALLLL--QMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAiP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 159 FNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQEKYTLQIGLQV 238
Cdd:COG3833  157 FNTWLMKGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 488215578 239 F-QNQATTQWNYLMAGATLVLIPTILLFFFAQRYFIEGmdLTGGS-KG 284
Cdd:COG3833  237 FvSDQRNTNWGVFAAGAVLVAIPIVILFLFLQRYLVSG--LTAGGvKG 282
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
46-276 2.03e-29

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 112.52  E-value: 2.03e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  46 EEIVRYPPTFFPEKIVWENyLDTI-------AAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALV 118
Cdd:PRK10973  39 QAVFAVPMTLIPGTHLLEN-IANIwvngvgnNSAPFGRMLLNSFVMAFSITVGKITVSMLSAFAIVWFRFPLRNLFFWMI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 119 LSTMMIPGFVTMIPQYVLFSKIGWVGTYLPLIVPsFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLT 198
Cdd:PRK10973 118 FITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLP-LMASATATFLFRQFFMTLPDELVEAARIDGASPMRFFWDIVLPLS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 199 KPALITIAINSFNAAWNDFLGPLLYIQDQEKYTLQIGLQ--VFQNQATTQWNYLMAGATLVLIPTILLFFFAQRYFIEGM 276
Cdd:PRK10973 197 KTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKgmIATGEGTTEWNQVMAAMLLTLIPPVVIVLAMQRAFVRGL 276
malG PRK10998
maltose ABC transporter permease MalG;
68-284 6.98e-25

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 100.94  E-value: 6.98e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  68 TIAAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIG----WV 143
Cdd:PRK10998  75 TPPPFPVLLWLWNSVKVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGqyipFI 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 144 G--TYLPLIVPSFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPL 221
Cdd:PRK10998 155 GlnTHGGVIFAYLGGIALHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVAS 234

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488215578 222 LYIQDQEKYTLQIGLQVFQNQATTQWNYLMAGATLVLIPTILLFFFAQRYFIEGMDlTGGSKG 284
Cdd:PRK10998 235 LLLRDVNSYTLAVGMQQYLNPQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLT-AGGVKG 296
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 53-271 1.08e-20

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 88.63  E-value: 1.08e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  53 PTFFPEKIVWENYLDTIAAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIP 132
Cdd:COG1177   38 LTFPPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVA 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 133 QYVLFSKIGWVGTYLPLIVP-SFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFN 211
Cdd:COG1177  118 LLLLFSALGLSGGLWGLILAhVVFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFT 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 212 AAWNDFLGPLLyIQDQEKYTLQIGLQVFQNQATTQwnYLMAGATLVLIPTILLFFFAQRY 271
Cdd:COG1177  198 LSFDEFVITLF-LAGPGVTTLPVYIYSMIRRGISP--EINALSTLLILLSLLLLLLAERL 254
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 78-262 2.93e-20

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 85.79  E-value: 2.93e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  78 ARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGWVG-----TYLPLIVP 152
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGilpglGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 153 SFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQEKYTL 232
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                        170       180       190
                 ....*....|....*....|....*....|
gi 488215578 233 QIGLQVFQNQATTQWNYLMAGATLVLIPTI 262
Cdd:cd06261  161 TGLLLIFAILFPGDLGVAAAVALILLLLSL 190
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
62-271 1.20e-14

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 73.66  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  62 WENYLDTIAAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIG 141
Cdd:COG1178   40 LANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVVALAWIALFGPNG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 142 WVGTYLP----LIVPSFFG-------NAFNIF-----LMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITI 205
Cdd:COG1178  120 LLNTLLRalfgLEPPDIYGlggiilvLVLFNYpyvylLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAG 199

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488215578 206 AINSFNAAWNDFLGPLLyiqdqekytLQIGLQVFQNQATTQWNYL----MAG--ATLVLIPTILLFFFAQRY 271
Cdd:COG1178  200 ALLVFLLCLADFGTPLV---------LGGGYTTLTTAIYQAWLGDfdlgAAAalALVLLLLVLLLLLLERRL 262
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 108-272 1.08e-11

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 62.32  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  108 FPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGWVGTYLPLIVPSFFGNAFNIFLMRQFYL-SINNELIEAAEIDGANH 186
Cdd:pfam00528  14 RRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALrSLPSDLVEAARALGASR 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  187 LYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQEKYTLQIglQVFQNQATTQWNYLMAGATLVLIPTILLFF 266
Cdd:pfam00528  94 WQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLI--EAILGYDYPEIQGPVLAAALILLLLNLLVD 171


                  ....*.
gi 488215578  267 FAQRYF 272
Cdd:pfam00528 172 ILQRLL 177
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 62-210 1.89e-08

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 53.99  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  62 WENYLDTIAAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIG 141
Cdd:COG0555   40 WAEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLPLAWVLVRYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPNG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 142 WVGTYLPLIVPSFfgnAFNI-------------FLMRQFY---LSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITI 205
Cdd:COG0555  120 WLGQLLAPLGIKV---AFTPlgivlaqtfvslpFVVRTVQpvlEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTG 196


                 ....*
gi 488215578 206 AINSF 210
Cdd:COG0555  197 FALAF 201
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
62-217 1.93e-08

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 54.37  E-value: 1.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  62 WENYLDTIAAFPFWRYARNTLFITVLVVIGNVLsnsfIAYGFAKL---DFPGKKLMFALVLSTMMIPGFVT-MIPQYVLF 137
Cdd:COG1175   62 LDNYARLFTDPRFWNALGNTLLFTVVSVPLQLV----LGLLLALLlnrKLRGRGFFRTLFFLPWVISPVVVaLIWKWLFN 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 138 SKIGWVGTYLPLI---VPSFFGNAFNIFLM-------RQF------YL----SINNELIEAAEIDGANHLYIWSHLMLPL 197
Cdd:COG1175  138 PDYGLLNALLGALglePINWLGDPSLALPAviivtvwKGTgfnmliFLaglqSIPRELYEAARIDGASPWQRFRRITLPL 217

                        170       180
                 ....*....|....*....|
gi 488215578 198 TKPALITIAINSFNAAWNDF 217
Cdd:COG1175  218 LRPTILFVLVLSTIGALQVF 237
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
54-270 3.89e-08

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 54.01  E-value: 3.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  54 TFFPEKIVWENYLDTIAAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQ 133
Cdd:COG1178  316 KALDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVLGLGL 395

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 134 YVLFSKIGWVGTY--LPLIVpsfFGNAFnIFL------MRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITI 205
Cdd:COG1178  396 LLLFNRPLPLLLYgtLAILV---LAYVV-RFLpfalrsLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAA 471

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488215578 206 AINSFNAAWNDF-LGPLLYIQDQEkyTLqiGLQVFQNQATTQWNYLMAGATLVLIPTILLFFFAQR 270
Cdd:COG1178  472 ALLVFVTSMKELsATLLLRPPGFE--TL--AVLIYQLASSGRYGEAAALALLLVLVSLLPVLLLER 533
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 36-272 1.03e-06

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 48.99  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  36 WMVFTSLKPMEEIVRYPPTFfpekiVWENYLDTIAAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMF 115
Cdd:COG1176   32 LLLVYSFTTRDPYGGVVPGF-----TLENYARLFTDPLYLKVLLRTLWIALLTTLICLLLGYPIAYFLARAPPRWRNLLL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 116 ALVLSTMMIPGFVTMIPQYVLFSKIGWVGTYL--------PLivpSFFGNAFNIFL-MRQFYL------------SINNE 174
Cdd:COG1176  107 LLVILPFWTSFLVRTYAWIVLLGRNGLLNSLLlalglidePL---RLLYTEFAVVIgLVYVYLpfmvlplyaaleKIDPS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 175 LIEAAEIDGANHLYIWSHLMLPLTKPALITIAINSFNAAWNDFLGPLLYIQDQekyTLQIGLQVFQNQATTQ-WNYLMAG 253
Cdd:COG1176  184 LLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALLGGGK---VLMIGNLIYQQFLSALnWPLAAAL 260

                        250
                 ....*....|....*....
gi 488215578 254 ATLVLIPTILLFFFAQRYF 272
Cdd:COG1176  261 AVVLLLIVLLVLLLYLRLL 279
cysT CHL00187
sulfate transport protein; Provisional
 81-230 2.83e-05

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 44.23  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  81 TLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGWVGTYLPL----IVPSFFG 156
Cdd:CHL00187  60 TLSMALIAALINGFFGLLIAWVLVRYNFPGKRLLDAAVDLPFALPTSVAGLTLATVYGDNGWIGHLLSHlgiqIVFTKLG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 157 NA---------FNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALIT---------------IAINSFNA 212
Cdd:CHL00187 140 VLlamifvsfpFVVRTIQPVLQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPALLTglaltfsraigeygsIVIISSNI 219

                        170
                 ....*....|....*...
gi 488215578 213 AWNDFLGPLLYIQDQEKY 230
Cdd:CHL00187 220 PFKDLVASVLIFQSLEQY 237
permease_CysT TIGR02139
sulfate ABC transporter, permease protein CysT; This model represents CysT, one of two ...
 62-204 5.15e-05

sulfate ABC transporter, permease protein CysT; This model represents CysT, one of two homologous, tandem permeases in the sulfate ABC transporter system; the other is CysW (TIGR02140). The sulfate transporter has been described in E. coli as transporting sulfate, thiosulfate, selenate, and selenite. Sulfate transporters may also transport molybdate ion if a specific molybdate transporter is not present. [Transport and binding proteins, Anions]


Pssm-ID: 131194  Cd Length: 265  Bit Score: 43.85  E-value: 5.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578   62 WENYLDTIAAfPFWRYARNTLFITVLVV-IGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKI 140
Cdd:TIGR02139  36 WAGFWQIITE-PRVLAAYKLSFGTALIAaLINAVFGTLLAWVLVRYRFPGKRIVDALVDLPFALPTAVAGIALATLYSPN 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488215578  141 GWVGTYLP-------------LIVPSFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALIT 204
Cdd:TIGR02139 115 GWIGSFLAplgikiaftplgiVIALVFVSLPFVVRTVQPVLEEIEKELEEAAASLGASRWQTFWRVILPALLPALLT 191
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 78-203 5.69e-04

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 40.35  E-value: 5.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  78 ARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFSKIGW-VGTYLPLIVPSFFG 156
Cdd:PRK09500  59 AQHSLTMAVFSATFATLIGSLTAVALYRYRFRGKKFVSGMLFVVMMSPDIVMAISLLVLFMLLGIqLGFWSLLFAHITFC 138

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 488215578 157 NAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALI 203
Cdd:PRK09500 139 LPFVVVTVYSRLKGFDVRMLEAAKDLGASEFTILRKIILPLALPAVA 185
PRK10971 PRK10971
sulfate/thiosulfate ABC transporter permease CysT;
59-267 4.26e-03

sulfate/thiosulfate ABC transporter permease CysT;


Pssm-ID: 182873  Cd Length: 277  Bit Score: 37.81  E-value: 4.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578  59 KIVWENYLDTIAAFPFWRYARNTLFITVLVVIGNVLSNSFIAYGFAKLDFPGKKLMFALVLSTMMIPGFVTMIPQYVLFS 138
Cdd:PRK10971  41 QMSWAQYWEVITNPQVVAAYKVTLLSAFVASIFNAVFGLLMAWILTRYRFPGRTLLDALMDLPFALPTAVAGLTLASLFS 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488215578 139 KIGWVGTYLP-------------LIVPSFFGNAFNIFLMRQFYLSINNELIEAAEIDGANHLYIWSHLMLPLTKPALITI 205
Cdd:PRK10971 121 VNGWYGEWLAkfdikvtytwlgiAVAMAFTSIPFVVRTVQPVLEELGPEYEEAAETLGATRWQSFRKVVLPELSPALLAG 200

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488215578 206 AINSFNAAWNDFlGPLLYIQDQEKY-TLQIGLQVFQNQATTQWNYLMAGATLVLIPTILLFFF 267
Cdd:PRK10971 201 VALSFTRSLGEF-GAVIFIAGNIAWkTEVTSLMIFVRLQEFDYPAASAIASVILAASLLLLFS 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH