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Conserved domains on  [gi|488217277|ref|WP_002288485|]
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MULTISPECIES: DeoR/GlpR family DNA-binding transcription regulator [Enterococcus]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-242 2.40e-94

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 277.40  E-value: 2.40e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAKKEQLLNFEQNMSEKSLKNVHEKQ 80
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  81 QIAKSAAETINDEDVIYLDAGSTTLEMIPFLQG-KQITVVTNSVQHAANLVDLELATIIL-GGTIKLATNAVLGSNAIEQ 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPNIEVILlGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 159 LKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAA-TIITER-CPLEFV 236
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIdVLITDAgPPPELL 240


                 ....*.
gi 488217277 237 NEFREK 242
Cdd:COG1349  241 EALEEA 246
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-242 2.40e-94

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 277.40  E-value: 2.40e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAKKEQLLNFEQNMSEKSLKNVHEKQ 80
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  81 QIAKSAAETINDEDVIYLDAGSTTLEMIPFLQG-KQITVVTNSVQHAANLVDLELATIIL-GGTIKLATNAVLGSNAIEQ 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPNIEVILlGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 159 LKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAA-TIITER-CPLEFV 236
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIdVLITDAgPPPELL 240


                 ....*.
gi 488217277 237 NEFREK 242
Cdd:COG1349  241 EALEEA 246
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 74-230 1.36e-58

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 183.10  E-value: 1.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   74 KNVHEKQQIAKSAAETINDEDVIYLDAGSTTLEMIPFLQGKQ-ITVVTNSVQHAANLVDLELATIIL-GGTIKLATNAVL 151
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRnLTVITNSLNIANELSEKPDIEVILlGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  152 GSNAIEQLKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAAT-IITER 230
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDaLITDK 160
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
1-230 7.58e-49

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 161.23  E-value: 7.58e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAKKEQLLNFEQNMSEKSLKNVHEKQ 80
Cdd:NF041397   1 MLPEERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPVTSVGRERSYGQREVQNLEAKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  81 QIAKSAAETINDEDVIYLDAGSTTLEMipflqGKQ------ITVVTNSVQHAANLVDLELATIILGGTIKLATNAVLGSN 154
Cdd:NF041397  81 AIAERAVEEIHDGQVVFFDAGTTTMEV-----AKRvptdgsFLAVTNSPLLALELAERDGEVKLTGGTLRPRTRALVGPT 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488217277 155 AIEQLKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAA-TIITER 230
Cdd:NF041397 156 AESFMERTNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVdLFVTDG 232
AgaR NF040755
transcriptional repressor AgaR;
3-241 1.23e-44

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 150.50  E-value: 1.23e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   3 TEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAkkeqLLN------FEQNMSEKSLKNV 76
Cdd:NF040755   4 TSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGA----LINdgfipgAEPSVEDKSRLNT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  77 HEKQQIAKSAAETINDEDVIYLDAGSTTLEMIPFLQGKQ-ITVVTNSVQHAANLVDLE-LATIILGGTIKLATNAVLGSN 154
Cdd:NF040755  80 AVKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQdVVVMTNGLNVANELLEAEgVEVLMTGGHLRRQSLSFYGDQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 155 AIEQLKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVapLEAA---TIIT-ER 230
Cdd:NF040755 160 AEQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKI--RDTGridTLITdSG 237

                        250
                 ....*....|.
gi 488217277 231 CPLEFVNEFRE 241
Cdd:NF040755 238 IPEEYLQGLRK 248
srlR PRK10434
DNA-binding transcriptional repressor;
1-242 7.30e-41

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 140.98  E-value: 7.30e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGA---KKEQllnfEQNMSEKSLKNVH 77
Cdd:PRK10434   1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVvlnKEES----DPPIDHKTLINTH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  78 EKQQIAKSAAETINDEDVIYLDAGSTTLEMIPFL-QGKQITVVTNSVqHAAN-LVDLELATIIL--GGTIKLATNAVLGS 153
Cdd:PRK10434  77 KKELIAEAAVSLIHDGDSIILDAGSTVLQMVPLLsRFNNITVMTNSL-HIVNaLSELDNEQTILmpGGTFRKKSASFHGQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 154 NAIEQLKNFHFNKAFMGMNGAHLEQGFTTPDpEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAA-TIITER-C 231
Cdd:PRK10434 156 LAENAFEHFTFDKLFIGTDGIDLNAGVTTFN-EVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVdKLITDAgI 234

                        250
                 ....*....|.
gi 488217277 232 PLEFVNEFREK 242
Cdd:PRK10434 235 DPAFRQALEEK 245
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-56 2.09e-17

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 73.41  E-value: 2.09e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 488217277     6 RRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGA 56
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 7-54 5.43e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.43  E-value: 5.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488217277   7 RQKILD--LLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHG 54
Cdd:cd07377   11 REAILSgeLKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPG 60
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-242 2.40e-94

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 277.40  E-value: 2.40e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAKKEQLLNFEQNMSEKSLKNVHEKQ 80
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  81 QIAKSAAETINDEDVIYLDAGSTTLEMIPFLQG-KQITVVTNSVQHAANLVDLELATIIL-GGTIKLATNAVLGSNAIEQ 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPNIEVILlGGELRPSSGSLVGPLAEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 159 LKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAA-TIITER-CPLEFV 236
Cdd:COG1349  161 LRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIdVLITDAgPPPELL 240


                 ....*.
gi 488217277 237 NEFREK 242
Cdd:COG1349  241 EALEEA 246
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 74-230 1.36e-58

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 183.10  E-value: 1.36e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   74 KNVHEKQQIAKSAAETINDEDVIYLDAGSTTLEMIPFLQGKQ-ITVVTNSVQHAANLVDLELATIIL-GGTIKLATNAVL 151
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRnLTVITNSLNIANELSEKPDIEVILlGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  152 GSNAIEQLKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAAT-IITER 230
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDaLITDK 160
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
1-230 7.58e-49

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 161.23  E-value: 7.58e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAKKEQLLNFEQNMSEKSLKNVHEKQ 80
Cdd:NF041397   1 MLPEERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPVTSVGRERSYGQREVQNLEAKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  81 QIAKSAAETINDEDVIYLDAGSTTLEMipflqGKQ------ITVVTNSVQHAANLVDLELATIILGGTIKLATNAVLGSN 154
Cdd:NF041397  81 AIAERAVEEIHDGQVVFFDAGTTTMEV-----AKRvptdgsFLAVTNSPLLALELAERDGEVKLTGGTLRPRTRALVGPT 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488217277 155 AIEQLKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAA-TIITER 230
Cdd:NF041397 156 AESFMERTNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVdLFVTDG 232
AgaR NF040755
transcriptional repressor AgaR;
3-241 1.23e-44

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 150.50  E-value: 1.23e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   3 TEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAkkeqLLN------FEQNMSEKSLKNV 76
Cdd:NF040755   4 TSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGA----LINdgfipgAEPSVEDKSRLNT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  77 HEKQQIAKSAAETINDEDVIYLDAGSTTLEMIPFLQGKQ-ITVVTNSVQHAANLVDLE-LATIILGGTIKLATNAVLGSN 154
Cdd:NF040755  80 AVKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQdVVVMTNGLNVANELLEAEgVEVLMTGGHLRRQSLSFYGDQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 155 AIEQLKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVapLEAA---TIIT-ER 230
Cdd:NF040755 160 AEQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKI--RDTGridTLITdSG 237

                        250
                 ....*....|.
gi 488217277 231 CPLEFVNEFRE 241
Cdd:NF040755 238 IPEEYLQGLRK 248
srlR PRK10434
DNA-binding transcriptional repressor;
1-242 7.30e-41

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 140.98  E-value: 7.30e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGA---KKEQllnfEQNMSEKSLKNVH 77
Cdd:PRK10434   1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVvlnKEES----DPPIDHKTLINTH 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  78 EKQQIAKSAAETINDEDVIYLDAGSTTLEMIPFL-QGKQITVVTNSVqHAAN-LVDLELATIIL--GGTIKLATNAVLGS 153
Cdd:PRK10434  77 KKELIAEAAVSLIHDGDSIILDAGSTVLQMVPLLsRFNNITVMTNSL-HIVNaLSELDNEQTILmpGGTFRKKSASFHGQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 154 NAIEQLKNFHFNKAFMGMNGAHLEQGFTTPDpEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAA-TIITER-C 231
Cdd:PRK10434 156 LAENAFEHFTFDKLFIGTDGIDLNAGVTTFN-EVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVdKLITDAgI 234

                        250
                 ....*....|.
gi 488217277 232 PLEFVNEFREK 242
Cdd:PRK10434 235 DPAFRQALEEK 245
PRK09802 PRK09802
DeoR family transcriptional regulator;
3-241 1.04e-35

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 127.66  E-value: 1.04e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   3 TEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAK--KEQLLNFEQNMSEKSLKNVHEKQ 80
Cdd:PRK09802  15 TSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALicDSTTPSVEPSVEDKSALNTAMKR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  81 QIAKSAAETINDEDVIYLDAGSTTLEMIPFL-QGKQITVVTNSVQHAANLVDLELATIIL-GGTIKLATNAVLGSNAIEQ 158
Cdd:PRK09802  95 SVAKAAVELIQPGHRVILDSGTTTFEIARLMrKHTDVIAMTNGMNVANALLEAEGVELLMtGGHLRRQSQSFYGDQAEQS 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 159 LKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAA-TIITERC-PLEFV 236
Cdd:PRK09802 175 LQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIdMIIVDEGiPADSL 254


                 ....*
gi 488217277 237 NEFRE 241
Cdd:PRK09802 255 EGLRK 259
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 4-241 6.08e-21

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 88.22  E-value: 6.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   4 EERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLervHGGAKKEQLLNFEQN-MSEKSLKNVHEKQQI 82
Cdd:PRK10681   6 DERIGQLLQALKRSDKLHLKDAAALLGVSEMTIRRDLNAHSAPVVL---LGGYIVLEPRSASHYlLSDQKSRLVEEKRRA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  83 AKSAAETINDEDVIYLDAGSTTLEMI-------PFlqgkqiTVVTNSVQHAANLVDLELATIIL-GGTIKlATNAVLGS- 153
Cdd:PRK10681  83 AQLAATLVEPNQTLFFDCGTTTPWIIeaidnelPF------TAVCYSLNTFLALQEKPHCRAILcGGEFH-ASNAIFKPl 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277 154 NAIEQLKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEA-ATIITERCP 232
Cdd:PRK10681 156 DFQQTLDNICPDIAFYSAAGVHVSKGATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRfDTVVSDRCP 235

                        250
                 ....*....|
gi 488217277 233 L-EFVNEFRE 241
Cdd:PRK10681 236 DdEFVKYAQA 245
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
1-210 5.27e-20

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 85.68  E-value: 5.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAKkeqLLNFEQNMS--EKSLKNVHE 78
Cdd:PRK10906   1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAA---LPSSSVNTPwhDRKATQTEE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  79 KQQIAKSAAETINDEDVIYLDAGsTTLEMI--PFLQGKQITVVTNSVQHAANLVDLELATIIL-GGTIKLATNAVLGSNA 155
Cdd:PRK10906  78 KERIARKVASQIPNGATLFIDIG-TTPEAVahALLNHSNLRIVTNNLNVANTLMAKEDFRIILaGGELRSRDGGIIGEAT 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488217277 156 IEQLKNFHFNKAFMGMNGAHLEQGFTTPDPEEAAVKRLAMKNSEETFVLIDHTKF 210
Cdd:PRK10906 157 LDFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKF 211
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
1-141 3.59e-19

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 83.52  E-value: 3.59e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   1 MLTEERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGA-KKEQLLNFEQNMSEKSLKNVHEK 79
Cdd:PRK13509   1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeAITQQRPRWTPMNIHQAQNHDEK 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488217277  80 QQIAKSAAETINDEDVIYLDAGSTTLEMIPFLQGKQITVVTNSVQHAANLVDLEL-ATIILGG 141
Cdd:PRK13509  81 VRIAKAASQLCNPGESVVINCGSTAFLLGRELCGKPVQIITNYLPLANYLIDQEHdSVIIMGG 143
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-56 2.09e-17

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 73.41  E-value: 2.09e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 488217277     6 RRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGA 56
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGA 51
PRK10411 PRK10411
L-fucose operon activator;
5-233 2.16e-17

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 78.69  E-value: 2.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277   5 ERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAKKEQLLNfeQNMSEK---SLKNVH-EKQ 80
Cdd:PRK10411   4 ARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQN--QDSGDPfhiRLKSHYaHKA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217277  81 QIAKSAAETINDEDVIYLDAGSTTLEMIPFLQGKQITVVTNSVQHAANLVDLELATIIL-GGTIKLATNAVLGSNAIEQL 159
Cdd:PRK10411  82 DIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRERIQLISsGGTLERKYGCYVNPSLISQL 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488217277 160 KNFHFNKAFMGMNGahLEQGFTTPDPEE--AAVKRLAMKNSEETFVLIDHTKFNQLSFTSVAPLEAAT-IITERCPL 233
Cdd:PRK10411 162 KSLEIDLFIFSCEG--IDSSGALWDSNAinADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVThIISDERQV 236
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
6-57 5.01e-14

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 64.59  E-value: 5.01e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 488217277    6 RRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAK 57
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAV 52
COG3177 COG3177
Fic family protein [Transcription];
5-55 1.67e-06

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 48.14  E-value: 1.67e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488217277   5 ERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHGG 55
Cdd:COG3177  261 ERQRKLLELLFENPVLTASELAELLGVSRRTARRDLKDLVELGILEKVGGG 311
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 5-54 8.40e-05

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 43.14  E-value: 8.40e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488217277   5 ERRQKILDLLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGF-LERVHG 54
Cdd:COG2378    5 ERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELGVpIEAERG 55
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 7-54 5.43e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.43  E-value: 5.43e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488217277   7 RQKILD--LLEQQKIVKSQDLVNLLNASESTIRRDLQELENSGFLERVHG 54
Cdd:cd07377   11 REAILSgeLKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPG 60
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
5-55 2.70e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 38.34  E-value: 2.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488217277   5 ERRQKILDLLEQQKIVKSqDLVNLLNASESTIRRDLQELENSGFLERVHGG 55
Cdd:COG4742   16 EKRKNILLLLAEGPKTRS-ELAESLDVSRSTILRQLKELEERGLIERDDGE 65
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
24-54 3.12e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 37.92  E-value: 3.12e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 488217277  24 DLVNLLNASESTIRRDLQELENSGFLERVHG 54
Cdd:COG2188   34 ELAEEFGVSRMTVRKALDELVEEGLLERRQG 64
ArgR COG1438
Arginine repressor [Transcription];
4-43 3.43e-03

Arginine repressor [Transcription];


Pssm-ID: 441047  Cd Length: 152  Bit Score: 37.03  E-value: 3.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 488217277   4 EERRQKILDLLEQQKIVKSQDLVNLL-----NASESTIRRDLQEL 43
Cdd:COG1438    4 AARQAKIKEIISEEEIETQEELVELLkeegfNVTQATVSRDLKEL 48
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 8-48 4.31e-03

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 34.33  E-value: 4.31e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 488217277    8 QKILDLL-EQQKIVKSQDLVNLLNASESTIRRDLQELENSGF 48
Cdd:pfam08279   1 LQILQLLlEARGPISGQELAEKLGVSRRTIRRDIKILEELGV 42
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-58 5.35e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 5.35e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488217277   2 LTEERRQKILDLLEQQKIvKSQDLVNLLNASESTIRRDLQELENSGFLERVHGGAKK 58
Cdd:cd00090    4 LSDPTRLRILRLLLEGPL-TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRV 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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