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Conserved domains on  [gi|488217924|ref|WP_002289132|]
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MULTISPECIES: carbohydrate ABC transporter permease [Enterococcus]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
10-289 1.65e-93

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 278.17  E-value: 1.65e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  10 GHAFLILPVILISIMVFIPMVLALITSFQ--SGPPVNMTFNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFI 87
Cdd:COG1175   20 AYLFLLPALLLLLVFVLYPLLYTLYLSFTdwNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  88 SNLLNdKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFS-QSGLVNNLLLGIGMidTPIGWLTHPIWARVLIILSITWRW 166
Cdd:COG1175  100 ALLLN-RKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNpDYGLLNALLGALGL--EPINWLGDPSLALPAVIIVTVWKG 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 167 TGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTLQLFDEVQNITGGGPANATTTLS 246
Cdd:COG1175  177 TGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNSTTTLV 256

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 488217924 247 QYIYNLSYKFTpNFGYAAAVSFVIVSFIVILSIIQTKVGGESR 289
Cdd:COG1175  257 LYIYQTAFQQF-DFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
10-289 1.65e-93

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 278.17  E-value: 1.65e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  10 GHAFLILPVILISIMVFIPMVLALITSFQ--SGPPVNMTFNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFI 87
Cdd:COG1175   20 AYLFLLPALLLLLVFVLYPLLYTLYLSFTdwNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  88 SNLLNdKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFS-QSGLVNNLLLGIGMidTPIGWLTHPIWARVLIILSITWRW 166
Cdd:COG1175  100 ALLLN-RKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNpDYGLLNALLGALGL--EPINWLGDPSLALPAVIIVTVWKG 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 167 TGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTLQLFDEVQNITGGGPANATTTLS 246
Cdd:COG1175  177 TGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNSTTTLV 256

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 488217924 247 QYIYNLSYKFTpNFGYAAAVSFVIVSFIVILSIIQTKVGGESR 289
Cdd:COG1175  257 LYIYQTAFQQF-DFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
14-281 1.03e-21

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 91.81  E-value: 1.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  14 LILPVILISIMVFI-PMVLALITSFQSGPPVNM--TFNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFISNL 90
Cdd:PRK10561   2 LVAPQLIITVIFFIwPAGEALWYSLQSVDPFGFssQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  91 LnDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQS-GLVNNLLLGIGMidtpiGW--LTHPIWARVLIILSITWRWT 167
Cdd:PRK10561  82 V-DYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGrGLITHFLAEFGY-----DWnhAQNSGQAMFLVVFASVWKQI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 168 GYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTI-GTLQLFDEVQNITGGGPANATTTLS 246
Cdd:PRK10561 156 SYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVyAFFDTFPVIDAATSGGPVQATTTLI 235

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 488217924 247 QYIYNLSYKFTpNFGYAAAVSFVIVSFIVILSIIQ 281
Cdd:PRK10561 236 YKIYREGFTGL-DLSSSAAQSVVLMFLVIVLTVVQ 269
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 12-209 6.35e-15

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 74.72  E-value: 6.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924   12 AFLILPVILISIMVFIPMVLALITSFQSGppvNMTFNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFISNLL 91
Cdd:TIGR03262   5 LLLAGMILALLLFLLLPLLALLTKSVYDS---DGDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924   92 NDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGLVNNLLLGigmidtpigwltHPIWARVLIILSITWRWTGYNM 171
Cdd:TIGR03262  82 TRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGLLKGLLGG------------FSIYGFWGIVIGEVFYTFPHAL 149

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 488217924  172 IFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLK 209
Cdd:TIGR03262 150 MILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAK 187
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 138-284 7.20e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 65.40  E-value: 7.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  138 IGMIDTPIGWLTHPIWARVLIILSITWRWTGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSI 217
Cdd:pfam00528  35 LAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLA 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488217924  218 TSTIGTLQLFDEVQNITGGGPANATTTLSQYIYNLSYKFTPNFGYAAAVSFVIVSFIVILSIIQTKV 284
Cdd:pfam00528 115 LAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 66-275 2.58e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.53  E-value: 2.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  66 FFNTFLYLLVQVPIMLFLALFISNLLNDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGlvnnlllgigmidtpi 145
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLL---------------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 146 GWLTHPIWARVLIILSITWrWTGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTLQ 225
Cdd:cd06261   65 GWGILPGLGLPALILALLL-IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALG 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 488217924 226 LFDEVQNITGGGPANATTTLSQYiynLSYKFTPNFGYAAAVSFVIVSFIV 275
Cdd:cd06261  144 EFALVSFLGGGEAPGPGTGLLLI---FAILFPGDLGVAAAVALILLLLSL 190
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
10-289 1.65e-93

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 278.17  E-value: 1.65e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  10 GHAFLILPVILISIMVFIPMVLALITSFQ--SGPPVNMTFNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFI 87
Cdd:COG1175   20 AYLFLLPALLLLLVFVLYPLLYTLYLSFTdwNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  88 SNLLNdKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFS-QSGLVNNLLLGIGMidTPIGWLTHPIWARVLIILSITWRW 166
Cdd:COG1175  100 ALLLN-RKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNpDYGLLNALLGALGL--EPINWLGDPSLALPAVIIVTVWKG 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 167 TGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTLQLFDEVQNITGGGPANATTTLS 246
Cdd:COG1175  177 TGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNSTTTLV 256

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 488217924 247 QYIYNLSYKFTpNFGYAAAVSFVIVSFIVILSIIQTKVGGESR 289
Cdd:COG1175  257 LYIYQTAFQQF-DFGYASAIAVVLFLIILVLTLLQLRLLRRRE 298
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 11-288 2.44e-40

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 142.15  E-value: 2.44e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  11 HAFLILPVILISIMVFIPMvLALITSFQ----SGPPVNMTFNGLGNYQRMLTDATFKKAFFNTFLY----LLVQVPIMLF 82
Cdd:COG4209   30 YLMLLPGLIYLLIFSYLPM-YGIVIAFKdynpFKGIFGSPWVGLKNFKFLFSSPDFWRVLRNTLLIsllkLVFGFPLPII 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  83 LALFISNLLNDKklkYKGLFRTAIFLPCITSMVSYSLIMKSLFSQS-GLVNNLLLGIGMidTPIGWLTHPIWARVLIILS 161
Cdd:COG4209  109 LALLLNELRSKR---FKKTVQTISYLPHFLSWVVVAGIVYQFLSPDtGLVNQLLRALGG--EPINFLTEPKYFRPIYVFS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 162 ITWRWTGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTLQL-FDEVQNITGGGPAN 240
Cdd:COG4209  184 GIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHITLPGIRPTIVILLILNIGNILNVgFEQIYLLYNPLNYS 263

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488217924 241 ATTTLSQYIYNLSYKfTPNFGYAAAVSFV--IVSFIVILS--IIQTKVGGES 288
Cdd:COG4209  264 TSDVIDTYVYRIGLQ-NGDYSYATAVGLFksVVGLILVLIanKIAKKLGEES 314
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 1-289 6.66e-30

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 114.09  E-value: 6.66e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924   1 MKQKDLFKNGHAFLILP-VILISIMVFIPMVLALITSFQSGPPVNMTFNG--LGNYQRMLTDATFKKAFFNTFLYLLVQV 77
Cdd:COG1176    1 MSAALRRRLRPLLLLLPaLLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGftLENYARLFTDPLYLKVLLRTLWIALLTT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  78 PIMLFLALFISNLLNDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGLVNNLLLGIGMIDTPIGWLTHPiWArvl 157
Cdd:COG1176   81 LICLLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSFLVRTYAWIVLLGRNGLLNSLLLALGLIDEPLRLLYTE-FA--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 158 IILSITWRWTGYnMIFFL-SGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTLQLFdEVQNITGG 236
Cdd:COG1176  157 VVIGLVYVYLPF-MVLPLyAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAF-VTPALLGG 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488217924 237 GpanATTTLSQYIYNLsYKFTPNFGYAAAVSFVIVSFIVILSIIQTKVGGESR 289
Cdd:COG1176  235 G---KVLMIGNLIYQQ-FLSALNWPLAAALAVVLLLIVLLVLLLYLRLLRRRR 283
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
14-281 1.03e-21

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 91.81  E-value: 1.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  14 LILPVILISIMVFI-PMVLALITSFQSGPPVNM--TFNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFISNL 90
Cdd:PRK10561   2 LVAPQLIITVIFFIwPAGEALWYSLQSVDPFGFssQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  91 LnDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQS-GLVNNLLLGIGMidtpiGW--LTHPIWARVLIILSITWRWT 167
Cdd:PRK10561  82 V-DYVVRGSRFYQTLMLLPYAVAPAVAAVLWIFLFNPGrGLITHFLAEFGY-----DWnhAQNSGQAMFLVVFASVWKQI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 168 GYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTI-GTLQLFDEVQNITGGGPANATTTLS 246
Cdd:PRK10561 156 SYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVyAFFDTFPVIDAATSGGPVQATTTLI 235

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 488217924 247 QYIYNLSYKFTpNFGYAAAVSFVIVSFIVILSIIQ 281
Cdd:PRK10561 236 YKIYREGFTGL-DLSSSAAQSVVLMFLVIVLTVVQ 269
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
10-289 2.13e-21

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 93.69  E-value: 2.13e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  10 GHAFLILPVILISIMVFIPMVLALITSFQsgppvnmtfNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFISN 89
Cdd:COG1178    9 PRLLLLLLALLLALLVLLPLLALLLRAFT---------DGLANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  90 LLNDKKLKYKGLFRTAIFLPCITS--MVSYSLIMksLFSQSGLVNNLLLGigmidtPIGWLTHPIWARVLIILSITWRWT 167
Cdd:COG1178   80 LLARTDFPGRRLLRWLLLLPLALPpyVVALAWIA--LFGPNGLLNTLLRA------LFGLEPPDIYGLGGIILVLVLFNY 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 168 GYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIIL------FTSITSTIGTLQLFdevqnitGGGpana 241
Cdd:COG1178  152 PYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAagallvFLLCLADFGTPLVL-------GGG---- 220

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 488217924 242 TTTLSQYIYNLsYKFTPNFGYAAAVSFVIVSFIVILSIIQTKVGGESR 289
Cdd:COG1178  221 YTTLTTAIYQA-WLGDFDLGAAAALALVLLLLVLLLLLLERRLRRRRR 267
malF PRK10999
maltose ABC transporter permease MalF;
49-284 6.78e-21

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 91.95  E-value: 6.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  49 GLGNYQRMLTDATFKKAFFNTFLYLLV----QVPIMLFLALFISNLLNDKKLKYKGLFRTAIFLP-CITSMVSYsLIMKS 123
Cdd:PRK10999 266 GWKNFTRVFTDEGIQKPFIAIFIWTVVfsllTVVLTVAVGMVLACLVQWEALKGKAVYRVLLILPyAVPSFISI-LIFKG 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 124 LFSQS-GLVN---NLLLGIgmidTPiGWLTHPIWARVLIILSITWRWTGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQ 199
Cdd:PRK10999 345 LFNQSfGEINmmlSALFGI----KP-AWFSDPTLAKTMILIVNTWLGYPYMMILCMGLLKAIPDDLYEASAMDGAGPFQN 419

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 200 FIKVTIPNL-KPIILFTsITSTIGTLQLFDEVQNITGGGP--------ANATTTLSQYIYNLSYK--FTPNFGYAAAVS- 267
Cdd:PRK10999 420 FFKITLPLLiKPLTPLM-IASFAFNFNNFVLIQLLTNGGPdmigtttpAGYTDLLVSYTYRIAFEggGGQDFGLAAAIAt 498

                        250
                 ....*....|....*....
gi 488217924 268 --FVIVSFIVILSIIQTKV 284
Cdd:PRK10999 499 liFLLVGALAILNLKATKM 517
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 10-280 8.58e-18

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 80.93  E-value: 8.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  10 GHAFLILPVILISIMVFIPMVLALITSFQSGPPVNMTFNG--LGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFI 87
Cdd:COG1177    5 GRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLTFPPEGftLRWYAELFSDPRLLDALLNSLLIALLSTLLATVLGTPA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  88 SNLLNDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGLVNNLLLGIGmidtpigwlthpiwARVLIILSITwrwt 167
Cdd:COG1177   85 ALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLIL--------------AHVVFTLPFV---- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 168 gynMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPII----LFTSITStigtlqlFDEVQ--NITGGGpanA 241
Cdd:COG1177  147 ---VLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGIlagaLLAFTLS-------FDEFVitLFLAGP---G 213

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 488217924 242 TTTLSQYIYN-LSYKFTPnfgYAAAVSFVIVSFIVILSII 280
Cdd:COG1177  214 VTTLPVYIYSmIRRGISP---EINALSTLLILLSLLLLLL 250
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 10-280 7.24e-17

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 78.60  E-value: 7.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  10 GHAFLILPVILISIMVFIPMVLALITSFQSG----------PPVNMTFnglGNYQRMLTDATFKKAFFNTFLYLLVQVPI 79
Cdd:COG0395   13 GRILLYLLLILLALLFLFPLYWMVVTSFKPPaeifsgppslLPSEFTL---ENYRAAFTDGPFGRYLLNSLIVAVVSTVL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  80 MLFLALFISNLLNDKKLKYKGLFRTAIFlpcITSMVSYSLIMKSLFSqsglvnnLLLGIGMIDTPIGwlthpiwarvLII 159
Cdd:COG0395   90 SLLLSSLAAYALARFRFRGRKLLFLLIL---ATLMIPGQVLLIPLYL-------LFRQLGLLNTYWG----------LIL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 160 LSITWRwTGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTL-QLFDEVQNITGggp 238
Cdd:COG0395  150 PYLAFG-LPFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWnDFLWPLILLTS--- 225

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 488217924 239 aNATTTLSQYIYNLSYKFTPNFGYAAAVSFVIVSFIVILSII 280
Cdd:COG0395  226 -PDLRTLPVGLASFQGQYGTDWGLLMAAAVIATLPVLILFLF 266
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 12-209 6.35e-15

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 74.72  E-value: 6.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924   12 AFLILPVILISIMVFIPMVLALITSFQSGppvNMTFNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFISNLL 91
Cdd:TIGR03262   5 LLLAGMILALLLFLLLPLLALLTKSVYDS---DGDFIGLANFAEYFATPGLLQSLGNSLTVSAIVTAIVVPLAFAFAYAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924   92 NDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGLVNNLLLGigmidtpigwltHPIWARVLIILSITWRWTGYNM 171
Cdd:TIGR03262  82 TRSRIPGKGAFRLVALLPLLAPSLLPAISLIYLFGNQGLLKGLLGG------------FSIYGFWGIVIGEVFYTFPHAL 149

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 488217924  172 IFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLK 209
Cdd:TIGR03262 150 MILVTALSLADGRLYEAARAMGASPWRTFFTVTLPGAK 187
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
12-286 8.14e-15

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 74.04  E-value: 8.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  12 AFLILPVILISIMVFIPMVLALITSFQSGPPVNMTfngLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFISNLL 91
Cdd:COG1178  289 LALALCLLLVLLGLLLPLLALLLWSLTKALDDNLT---LDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLV 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  92 NDKKLKYKGLFRTAIFLPcitsmvsYSLimkslfsqSGLVnnllLGIGMI----DTPIGWLTHPIWarvLIILSITWRWT 167
Cdd:COG1178  366 RRRRGRLARLLDRLAMLP-------YAV--------PGIV----LGLGLLllfnRPLPLLLYGTLA---ILVLAYVVRFL 423

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 168 GYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKP------IILFTSITSTIGTLQLFdevqnitggGPANa 241
Cdd:COG1178  424 PFALRSLEAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPgllaaaLLVFVTSMKELSATLLL---------RPPG- 493

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 488217924 242 TTTLSQYIYNLSYkfTPNFGYAAAVSFVIVSFIVILSIIQTKVGG 286
Cdd:COG1178  494 FETLAVLIYQLAS--SGRYGEAAALALLLVLVSLLPVLLLERLLG 536
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 138-284 7.20e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 65.40  E-value: 7.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  138 IGMIDTPIGWLTHPIWARVLIILSITWRWTGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSI 217
Cdd:pfam00528  35 LAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLA 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488217924  218 TSTIGTLQLFDEVQNITGGGPANATTTLSQYIYNLSYKFTPNFGYAAAVSFVIVSFIVILSIIQTKV 284
Cdd:pfam00528 115 LAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 66-275 2.58e-11

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 61.53  E-value: 2.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  66 FFNTFLYLLVQVPIMLFLALFISNLLNDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGlvnnlllgigmidtpi 145
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLL---------------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 146 GWLTHPIWARVLIILSITWrWTGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTLQ 225
Cdd:cd06261   65 GWGILPGLGLPALILALLL-IAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALG 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 488217924 226 LFDEVQNITGGGPANATTTLSQYiynLSYKFTPNFGYAAAVSFVIVSFIV 275
Cdd:cd06261  144 EFALVSFLGGGEAPGPGTGLLLI---FAILFPGDLGVAAAVALILLLLSL 190
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 1-223 5.63e-11

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 61.71  E-value: 5.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924   1 MKQKDLFKNGHAFLILpvILISIMVFIPMVLALITSFQSGP--------PVNMTFNglgNYQRMLTDATFKKAFFNTFLY 72
Cdd:COG3833    7 RKRRRRLKLGLRHLVL--IILAIIALFPILWVVSASFNPGGslysssliPENFTLE---NYKKLFTETPFLRWFLNSLIV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  73 LLVQVPIMLFLALFISNLLNdkKLKYKGLfRTAIFLPCITSMVSYSLIMKSLFSqsglvnnLLLGIGMIDTPIGwlthpi 152
Cdd:COG3833   82 AVVTAIISVFLAALAAYAFS--RFRFKGR-KAGLLALLLLQMFPAFLALVALYL-------LLSALGLLNTLLG------ 145

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488217924 153 warvLIILSI-------TWRWTGYnmifflsgMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGT 223
Cdd:COG3833  146 ----LILVYLggaipfnTWLMKGY--------FDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGP 211
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 13-279 5.42e-10

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 58.61  E-value: 5.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  13 FLILPVILISIMVFIPMVLALITSFQSGPpvnmtfnglGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFISNLLN 92
Cdd:COG0555   12 TLGLTLLYLSLIVLLPLAALVLKAAGLGW---------AEFWAVLTSPRVLAALKLSLGTALIAALINLVFGLPLAWVLV 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  93 DKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGLVNNLL--LGIGMIDTPIGwlthpiwarvlIILSITWRWTGYN 170
Cdd:COG0555   83 RYRFPGKRLVDALVDLPFALPTAVAGIALLLLFGPNGWLGQLLapLGIKVAFTPLG-----------IVLAQTFVSLPFV 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924 171 MIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILFTSITSTIGTLQLFDEVQNITGGGPaNATTTLSQYIY 250
Cdd:COG0555  152 VRTVQPVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFALAFARALGEFGAVIFIAGNLP-MKTEILPLLIY 230

                        250       260       270
                 ....*....|....*....|....*....|....
gi 488217924 251 -NLSYkftpnFGYAAAVSF----VIVSFIVILSI 279
Cdd:COG0555  231 lKLEE-----GDYAGATAIalvlLLISFLLLLLI 259
potB PRK09497
spermidine/putrescine ABC transporter membrane protein; Reviewed
 1-213 1.70e-09

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 181910  Cd Length: 285  Bit Score: 57.39  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924   1 MKQKDLFKNGHAFLIlpVILISIMVFIPMVLALITSF---QSGPPVNMTFNgLGNYQRMLtDATFKKAFFNTFLYLLVQV 77
Cdd:PRK09497   1 MKNTSKFQNVVIVTI--VGWLVLFVFLPNLMIIGTSFltrDDANFVKMVFT-LDNYTRLL-DPLYAEVLLHSLNMALIAT 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  78 PIMLFLALFISNLLNDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGLVNNLLLGIGMIDTPIGWLTHPiwarVL 157
Cdd:PRK09497  77 LACLVLGYPFAWFLAKLPHKVRPLLLFLLIVPFWTNSLIRIYGLKIFLSTKGYLNEFLLWLGVIDTPIRIMFTE----SA 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488217924 158 IILSITWRWTGYNMIFFLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIIL 213
Cdd:PRK09497 153 VIIGLVYILLPFMVLPLYSSIEKLDKPLLEAARDLGANKLQTFIRIIIPLTMPGII 208
cysT CHL00187
sulfate transport protein; Provisional
 178-213 3.83e-03

sulfate transport protein; Provisional


Pssm-ID: 214388 [Multi-domain]  Cd Length: 237  Bit Score: 38.07  E-value: 3.83e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 488217924 178 MQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIIL 213
Cdd:CHL00187 160 LQEIEKELEEAAWSLGASPWQTFWKVIFPPLIPALL 195
cysW PRK11602
sulfate/thiosulfate ABC transporter permease CysW;
10-214 6.82e-03

sulfate/thiosulfate ABC transporter permease CysW;


Pssm-ID: 183225  Cd Length: 283  Bit Score: 37.42  E-value: 6.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  10 GHAFLILPVILISI-MVFIPMVLALITSFQsgppvnmtfNGLGNYQRMLTDATFKKAFFNTFLYLLVQVPIMLFLALFIS 88
Cdd:PRK11602  18 GKWFLIGIGMLVSAfILVVPMIYIFVQAFS---------KGLMPVLQNLADPDMLHAIWLTVLIALIAVPVNLVFGILLA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488217924  89 NLLNDKKLKYKGLFRTAIFLPCITSMVSYSLIMKSLFSQSGLVNnlllgigmidtpiGWL-THPIwarvliilSITWRWT 167
Cdd:PRK11602  89 WLVTRFNFPGRQLLLTLLDIPFAVSPVVAGLVYLLFYGSNGPLG-------------GWLdEHNL--------QLMFSWP 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 488217924 168 GYNM--IF---------FLSGMQNIDSEIYEAASIDGASKWQQFIKVTIPNLKPIILF 214
Cdd:PRK11602 148 GMVLvtIFvtcpfvvreLVPVMLSQGSQEDEAAILLGASGWQMFRRVTLPNIRWALLY 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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