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Conserved domains on  [gi|488218028|ref|WP_002289236|]
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MULTISPECIES: pentapeptide repeat-containing protein [Enterococcus]

Protein Classification

pentapeptide repeat-containing protein( domain architecture ID 11442852)

pentapeptide repeat-containing protein (PRP) adopts a beta-helical structure and may have a targeting or structural function

CATH:  2.160.20.10
PubMed:  33925937|9655353

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
52-200 5.65e-27

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


:

Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 101.17  E-value: 5.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218028  52 FKYAFFASNDFQRMEITDCIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLMESYIGNtlFENCKMDYVNLSGSNIKEST 131
Cdd:COG1357   31 LSGANLSGANLSGANLTGANLSGADLSGADLSGANLSGADLSGANLTGADLSGANLAN--LSGANLSGANLSGANLRGAN 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218028 132 FEHSVLSSADFVDCSLTKIMFSTNDLENASFFDTDLKNIDLSSNSFEMIEVRSEHLKNCTLNQLQALGF 200
Cdd:COG1357  109 LSGANLSGADLSGADLSGANLSGADLSGANLSGANLSGADLSGADLSGANLSGANLSGANLANLEGADL 177
 
Name Accession Description Interval E-value
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
52-200 5.65e-27

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 101.17  E-value: 5.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218028  52 FKYAFFASNDFQRMEITDCIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLMESYIGNtlFENCKMDYVNLSGSNIKEST 131
Cdd:COG1357   31 LSGANLSGANLSGANLTGANLSGADLSGADLSGANLSGADLSGANLTGADLSGANLAN--LSGANLSGANLSGANLRGAN 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218028 132 FEHSVLSSADFVDCSLTKIMFSTNDLENASFFDTDLKNIDLSSNSFEMIEVRSEHLKNCTLNQLQALGF 200
Cdd:COG1357  109 LSGANLSGADLSGADLSGANLSGADLSGANLSGANLSGADLSGADLSGANLSGANLSGANLANLEGADL 177
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
66-142 1.95e-12

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 60.37  E-value: 1.95e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488218028   66 EITDCIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLMESYIGNTLFENCKMDYVNLSGSNIKESTFEHSVLSSADF 142
Cdd:pfam13599   2 DFTRCSFEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVKLKGADF 78
PRK15196 PRK15196
type III secretion system effector PipB2;
72-196 2.43e-03

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 38.06  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218028  72 FENCDFSGCILTKSMLHRVKFVNCKLTGTklmesyigntlfencKMDYVNLSGSNIKESTFEHSVLSSADFVDCSLTKIM 151
Cdd:PRK15196 224 LDHANLTGANLQHASLLGCSMIECNCSGA---------------NMDHTNLSGATLIRADMSGATLQGATIMAAIMEGAV 288

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 488218028 152 FSTNDLENASFFDTDLKNIDLSSnsfemIEVRSEHLKNCTLNQLQ 196
Cdd:PRK15196 289 LTRANLRKASFISTNLDGADLAE-----ANLNNTCFKDCTLTHLR 328
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 51-119 4.83e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 37.21  E-value: 4.83e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218028  51 IFKYAFFASNDFQRMEITDCIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLMESYigntlfENCKMDY 119
Cdd:cd17438  267 TFEDSLFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFIDCRFINSTFLEQK------EGCHMDF 329
 
Name Accession Description Interval E-value
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
52-200 5.65e-27

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 101.17  E-value: 5.65e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218028  52 FKYAFFASNDFQRMEITDCIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLMESYIGNtlFENCKMDYVNLSGSNIKEST 131
Cdd:COG1357   31 LSGANLSGANLSGANLTGANLSGADLSGADLSGANLSGADLSGANLTGADLSGANLAN--LSGANLSGANLSGANLRGAN 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218028 132 FEHSVLSSADFVDCSLTKIMFSTNDLENASFFDTDLKNIDLSSNSFEMIEVRSEHLKNCTLNQLQALGF 200
Cdd:COG1357  109 LSGANLSGADLSGADLSGANLSGADLSGANLSGANLSGADLSGADLSGANLSGANLSGANLANLEGADL 177
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
66-142 1.95e-12

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 60.37  E-value: 1.95e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488218028   66 EITDCIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLMESYIGNTLFENCKMDYVNLSGSNIKESTFEHSVLSSADF 142
Cdd:pfam13599   2 DFTRCSFEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVKLKGADF 78
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
87-162 2.18e-10

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 54.97  E-value: 2.18e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488218028   87 LHRVKFVNCKLTGTKLMESYIGNTLFENCKMDYVNLSGSNIKESTFEHSVLSSADFVDCSLTKIMFSTNDLENASF 162
Cdd:pfam13599   3 FTRCSFEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVKLKGADF 78
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
107-178 4.28e-07

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 46.11  E-value: 4.28e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488218028  107 IGNTLFENCKMDYVNLSGSNIKESTFEHSVLSSADFVDCSLTKIMFSTNDLENASFFDTDLKNIDLSSNSFE 178
Cdd:pfam13599   3 FTRCSFEGCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVKLK 74
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
49-144 7.23e-07

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 47.63  E-value: 7.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218028  49 KSIFKYAFFASNDFQRMEITDCIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLmesyigntlfenckmDYVNLSGSNIK 128
Cdd:COG1357   91 GANLSGANLSGANLRGANLSGANLSGADLSGADLSGANLSGADLSGANLSGANL---------------SGADLSGADLS 155

                         90
                 ....*....|....*.
gi 488218028 129 ESTFEHSVLSSADFVD 144
Cdd:COG1357  156 GANLSGANLSGANLAN 171
YjbI COG1357
Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];
102-173 3.08e-05

Uncharacterized conserved protein YjbI, contains pentapeptide repeats [Function unknown];


Pssm-ID: 440968 [Multi-domain]  Cd Length: 178  Bit Score: 43.01  E-value: 3.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488218028 102 LMESYIGNTLFENCKMDYVNLSGSNIkESTFEHSVLSSADFVDCSLTKIMFSTNDLENASFFDTDLKNIDLS 173
Cdd:COG1357    2 LSGADLSGADLSGADLSGADLSGANL-SGALSGANLSGANLSGANLTGANLSGADLSGADLSGANLSGADLS 72
Pentapeptide_4 pfam13599
Pentapeptide repeats (9 copies);
112-192 1.93e-04

Pentapeptide repeats (9 copies);


Pssm-ID: 433339 [Multi-domain]  Cd Length: 78  Bit Score: 38.79  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218028  112 FENCKMDyvnlsGSNIKESTFEHSVLSSADFVDCSLTKIMFSTNDLENASFFDTDLKNIDLSSNSFEMIEVRSEHLKNCT 191
Cdd:pfam13599   3 FTRCSFE-----GCKLSGTEFYHATLKDCNFTECNLVNVNFDDCNLRDVDFLEAQLKNAQFSGCNLKNSNFSDVKLKGAD 77


                  .
gi 488218028  192 L 192
Cdd:pfam13599  78 F 78
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 61-99 2.12e-03

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 34.62  E-value: 2.12e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 488218028   61 DFQRMEITDCIFENCDFSGCILTKSMLHRVKFVNCKLTG 99
Cdd:pfam00805   2 NLSGANLSGANLSGANLSGANLTGANLSGADLSGANLSG 40
PRK15196 PRK15196
type III secretion system effector PipB2;
72-196 2.43e-03

type III secretion system effector PipB2;


Pssm-ID: 185118 [Multi-domain]  Cd Length: 350  Bit Score: 38.06  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218028  72 FENCDFSGCILTKSMLHRVKFVNCKLTGTklmesyigntlfencKMDYVNLSGSNIKESTFEHSVLSSADFVDCSLTKIM 151
Cdd:PRK15196 224 LDHANLTGANLQHASLLGCSMIECNCSGA---------------NMDHTNLSGATLIRADMSGATLQGATIMAAIMEGAV 288

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 488218028 152 FSTNDLENASFFDTDLKNIDLSSnsfemIEVRSEHLKNCTLNQLQ 196
Cdd:PRK15196 289 LTRANLRKASFISTNLDGADLAE-----ANLNNTCFKDCTLTHLR 328
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 51-119 4.83e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 37.21  E-value: 4.83e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218028  51 IFKYAFFASNDFQRMEITDCIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLMESYigntlfENCKMDY 119
Cdd:cd17438  267 TFEDSLFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFIDCRFINSTFLEQK------EGCHMDF 329
Pentapeptide pfam00805
Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The ...
 70-105 8.01e-03

Pentapeptide repeats (8 copies); These repeats are found in many cyanobacterial proteins. The repeats were first identified in hglK. The function of these repeats is unknown. The structure of this repeat has been predicted to be a beta-helix. The repeat can be approximately described as A(D/N)LXX, where X can be any amino acid.


Pssm-ID: 459943 [Multi-domain]  Cd Length: 40  Bit Score: 33.08  E-value: 8.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 488218028   70 CIFENCDFSGCILTKSMLHRVKFVNCKLTGTKLMES 105
Cdd:pfam00805   1 ANLSGANLSGANLSGANLSGANLTGANLSGADLSGA 36
PRK15377 PRK15377
type III secretion system effector HECT-type E3 ubiquitin transferase;
57-169 9.64e-03

type III secretion system effector HECT-type E3 ubiquitin transferase;


Pssm-ID: 185275 [Multi-domain]  Cd Length: 782  Bit Score: 36.58  E-value: 9.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218028  57 FASNDFQRMEITDCIFENCDFSGCILTKSMLHRVKfvncKLTGTKLMESYIGNTLFENCKMDYVNLSGSNIKESTFEHSV 136
Cdd:PRK15377 192 YADRDFSNADFRNINFSKINPSGFMLRDGDIIKGF----NFSNSKFTYSDISHLHFDECRFTYSTLSDVVCSNTKFSNSD 267

                         90       100       110
                 ....*....|....*....|....*....|...
gi 488218028 137 LSSADFVDCSLTKimfstndlENASFFDTDLKN 169
Cdd:PRK15377 268 MNEASLKYSITTQ--------QQPSFIETTLKN 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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