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Conserved domains on  [gi|488218389|ref|WP_002289597|]
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MULTISPECIES: response regulator [Enterococcus]

Protein Classification

DNA-binding response regulator; response regulator( domain architecture ID 11450986)

two-component system response regulator binds DNA upon phosphorylation and functions as a transcriptional regulator| response regulator receives the signal from a sensor partner in two-component systems through its receiver (REC) domain

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
1-207 4.57e-35

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 120.38  E-value: 4.57e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILakfpkailll 80
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL---------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  81 lttfkdeeyireafsigvkgylikqnlqaiipsvksayngqavfgneiietftqmmknkptidshayasfSERELAIIKE 160
Cdd:COG2197   71 ----------------------------------------------------------------------TPREREVLRL 80
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 488218389 161 VAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:COG2197   81 LAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
REC super family cl19078
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
47-104 1.15e-08

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


The actual alignment was detected with superfamily member cd17557:

Pssm-ID: 473134 [Multi-domain]  Cd Length: 129  Bit Score: 51.65  E-value: 1.15e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488218389  47 RPDVLLTDIRMPKQTGIDAAKEI-----LAKFPKAIlllLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17557   52 RPDLILLDLNMPRMDGFEVLREIkadpdLRRIPVVV---LTTSDAEEDIERAYELGANSYIVK 111
 
Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
1-207 4.57e-35

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 120.38  E-value: 4.57e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILakfpkailll 80
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL---------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  81 lttfkdeeyireafsigvkgylikqnlqaiipsvksayngqavfgneiietftqmmknkptidshayasfSERELAIIKE 160
Cdd:COG2197   71 ----------------------------------------------------------------------TPREREVLRL 80
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 488218389 161 VAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:COG2197   81 LAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
3-207 3.41e-30

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 110.50  E-value: 3.41e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:PRK10651   8 TILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIKQ-NLQAIIPSVKSAYNGQAVFGNEIIETFTQMMKNKPTIDSHAYASFSERELAIIKEV 161
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLKDmEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRATTERDVNQLTPRERDILKLI 167
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 488218389 162 AAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:PRK10651 168 AQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQE 213
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
4-104 9.90e-28

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 101.43  E-value: 9.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTT 83
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80
                         90       100
                 ....*....|....*....|.
gi 488218389  84 FKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLK 101
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
148-204 1.05e-17

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 73.72  E-value: 1.05e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 488218389   148 ASFSERELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYF 204
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
4-104 1.37e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 74.88  E-value: 1.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389    4 VVIIDDDPFVTKSLQTILEstKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTT 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLE--KEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78
                          90       100
                  ....*....|....*....|.
gi 488218389   84 FKDEEYIREAFSIGVKGYLIK 104
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSK 99
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
47-104 1.15e-08

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 51.65  E-value: 1.15e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488218389  47 RPDVLLTDIRMPKQTGIDAAKEI-----LAKFPKAIlllLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17557   52 RPDLILLDLNMPRMDGFEVLREIkadpdLRRIPVVV---LTTSDAEEDIERAYELGANSYIVK 111
 
Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
1-207 4.57e-35

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 120.38  E-value: 4.57e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILakfpkailll 80
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL---------- 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  81 lttfkdeeyireafsigvkgylikqnlqaiipsvksayngqavfgneiietftqmmknkptidshayasfSERELAIIKE 160
Cdd:COG2197   71 ----------------------------------------------------------------------TPREREVLRL 80
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 488218389 161 VAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:COG2197   81 LAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
3-207 3.41e-30

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 110.50  E-value: 3.41e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:PRK10651   8 TILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIKQ-NLQAIIPSVKSAYNGQAVFGNEIIETFTQMMKNKPTIDSHAYASFSERELAIIKEV 161
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLKDmEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRATTERDVNQLTPRERDILKLI 167
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 488218389 162 AAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:PRK10651 168 AQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQE 213
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
3-104 3.75e-28

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 101.77  E-value: 3.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80
                         90       100
                 ....*....|....*....|..
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIK 104
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLK 102
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
4-104 9.90e-28

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 101.43  E-value: 9.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTT 83
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTA 80
                         90       100
                 ....*....|....*....|.
gi 488218389  84 FKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLK 101
PRK09483 PRK09483
response regulator; Provisional
1-202 1.89e-25

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 98.25  E-value: 1.89e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK-QNLQAIIPSVKSAYNGQAVFGNEIIEtftQMMKN--KPTIDShAYASFSERELAI 157
Cdd:PRK09483  81 LTVHTENPLPAKVMQAGAAGYLSKgAAPQEVVSAIRSVHSGQRYIASDIAQ---QMALSqiEPATEN-PFASLSERELQI 156
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 488218389 158 IKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLR---DRTQLAI 202
Cdd:PRK09483 157 MLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISgdvELTHLAI 204
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
1-104 3.72e-25

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 95.42  E-value: 3.72e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82
                         90       100
                 ....*....|....*....|....
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIK 106
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
4-104 1.18e-23

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 90.86  E-value: 1.18e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKeirvLGIGHCA-----KDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAIL 78
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEE----LGFEVVGeaengEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKI 76
                         90       100
                 ....*....|....*....|....*.
gi 488218389  79 LLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17536   77 IILSGYDDFEYAQKAIRLGVVDYLLK 102
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
4-207 1.91e-23

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 92.99  E-value: 1.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTT 83
Cdd:PRK10403   9 VLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  84 FKDEEYIREAFSIGVKGYLIKQNL-QAIIPSVKSAYNGQAVFGNEIIETFTQMMKNKPTIDShaYASFSERELAIIKEVA 162
Cdd:PRK10403  89 SDASSDVFALIDAGADGYLLKDSDpEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDP--FSVLTERELDVLHELA 166
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 488218389 163 AGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:PRK10403 167 QGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATILFLQQ 211
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
1-104 3.32e-20

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 84.87  E-value: 3.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80
                         90       100
                 ....*....|....*....|....
gi 488218389  81 LTTFkdEEYIREAFSIGVKGYLIK 104
Cdd:COG3279   81 TTAY--DEYALEAFEVNAVDYLLK 102
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
4-104 4.31e-20

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 81.55  E-value: 4.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTT 83
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTT 80
                         90       100
                 ....*....|....*....|.
gi 488218389  84 FKDEEYIREAFSIGVKGYLIK 104
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLK 101
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
4-104 7.17e-19

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 78.61  E-value: 7.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEiRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAIlLLLTT 83
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEEAGY-EVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPI-VLLTA 80
                         90       100
                 ....*....|....*....|.
gi 488218389  84 FKDEEYIREAFSIGVKGYLIK 104
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVK 101
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
1-117 8.58e-19

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 83.47  E-value: 8.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILEStKEIRVLGIgHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLER-AGYEVETA-ASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVIL 79
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK-QNLQAIIPSVKSA 117
Cdd:COG2204   80 LTGYGDVETAVEAIKAGAFDYLTKpFDLEELLAAVERA 117
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
148-204 1.05e-17

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 73.72  E-value: 1.05e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 488218389   148 ASFSERELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYF 204
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
6-104 1.14e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 74.57  E-value: 1.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   6 IIDDDPFVTKSLQTILESTKEIrvLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTTFK 85
Cdd:cd00156    2 IVDDDPAIRELLKSLLEREGYE--VDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKA 79
                         90
                 ....*....|....*....
gi 488218389  86 DEEYIREAFSIGVKGYLIK 104
Cdd:cd00156   80 DEEDAVRALELGADDYLVK 98
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
4-104 1.37e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 74.88  E-value: 1.37e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389    4 VVIIDDDPFVTKSLQTILEstKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTT 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLE--KEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTA 78
                          90       100
                  ....*....|....*....|.
gi 488218389   84 FKDEEYIREAFSIGVKGYLIK 104
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSK 99
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
1-104 1.38e-17

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 75.27  E-value: 1.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTkEIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI--LAKFPKAIL 78
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLLERL-GYEVTTAED-GAEALELLRAGPPDLILLDINMPGMDGLELLRRIraLPRLPDIPI 82
                         90       100
                 ....*....|....*....|....*.
gi 488218389  79 LLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:COG0784   83 IALTAYADEEDRERALEAGADDYLTK 108
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
2-104 2.30e-17

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 74.59  E-value: 2.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLL 81
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVV 80
                         90       100
                 ....*....|....*....|...
gi 488218389  82 TTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd19925   81 TAANDVETVREALRLGVVDYLIK 103
PRK15369 PRK15369
two component system response regulator;
2-200 2.66e-17

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 76.66  E-value: 2.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKEIRVlgIGHcAKDALVLYET---HRPDVLLTDIRMPKQTGIDAAKEILAKFPKAIL 78
Cdd:PRK15369   4 YKILLVDDHELIINGIKNMLAPYPRYKI--VGQ-VDNGLEVYNAcrqLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  79 LLLTTFKDEEYIREAFSIGVKGYLIKQNLQAII-PSVKSAYNGQA----VFGNEIIETFTQMMKNKPTIdshayasFSER 153
Cdd:PRK15369  81 LVLTARQEEHMASRTLAAGALGYVLKKSPQQILlAAIQTVAVGKRyidpALNREAILALLNADDTNPPL-------LTPR 153
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 488218389 154 ELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQL 200
Cdd:PRK15369 154 ERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAEL 200
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
3-195 7.86e-17

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 75.14  E-value: 7.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTkEIRVLGIGhCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:COG4566    1 TVYIVDDDEAVRDSLAFLLESA-GLRVETFA-SAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIKQ-NLQAIIPSVKSAyngqavfgneiIETFTQMMKNKPTIDSHA--YASFSERELAIIK 159
Cdd:COG4566   79 GHGDVPMAVRAMKAGAVDFLEKPfDDQALLDAVRRA-----------LARDRARRAERARRAELRarLASLTPREREVLD 147
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 488218389 160 EVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLR 195
Cdd:COG4566  148 LVVAGLSNKQIARELGISPRTVEVHRANVMEKLGAR 183
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
3-192 8.27e-17

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 75.32  E-value: 8.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILEStKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:PRK09958   2 NAIIIDDHPLAIAAIRNLLIK-NDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIK-QNLQAIIPSVKSAYNGQAVFgneiiETFTQMMKNKPTIDSHAYASFSERELAIIKEV 161
Cdd:PRK09958  81 AKNDHFYGKHCADAGANGFVSKkEGMNNIIAAIEAAKNGYCYF-----PFSLNRFVGSLTSDQQKLDSLSKQEISVMRYI 155
                        170       180       190
                 ....*....|....*....|....*....|.
gi 488218389 162 AAGKNNKEIADALYLSDGTVRNYISQLLEKL 192
Cdd:PRK09958 156 LDGKDNNDIAEKMFISNKTVSTYKSRLMEKL 186
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
135-207 1.58e-16

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 71.14  E-value: 1.58e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488218389 135 MMknkPTIDSHAYASFSERELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:COG5905    1 MM---PSSSTSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRL 70
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
2-104 1.98e-16

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 71.93  E-value: 1.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKEIrVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLL 81
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYE-VVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMC 79
                         90       100
                 ....*....|....*....|...
gi 488218389  82 TTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17542   80 SAMGQEEMVKEAIKAGAKDFIVK 102
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
3-207 2.20e-16

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 74.14  E-value: 2.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:PRK09935   5 SVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIKQN-LQAIIPSVKSAYNGQAVFGNEiieTFTQMMKNKPTIDSHAYASFSERELAIIKEV 161
Cdd:PRK09935  85 SKSECFYAGRAIQAGANGFVSKCNdQNDIFHAVQMILSGYTFFPSE---TLNYIKSNKCSTNSSTDTVLSNREVTILRYL 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 488218389 162 AAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:PRK09935 162 VSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLH 207
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-104 4.70e-16

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 75.66  E-value: 4.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILeSTKEIRVlgigHCAKD---ALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILL 79
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAF-ALQGFET----HCANNgrtALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVI 80
                         90       100
                 ....*....|....*....|....*
gi 488218389  80 LLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:PRK11361  81 LMTAYAEVETAVEALRCGAFDYVIK 105
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
2-80 6.21e-16

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 70.88  E-value: 6.21e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILESDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERPTPVVMV 79
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
4-104 3.32e-15

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 68.72  E-value: 3.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEiLAKFPKAILLLLTT 83
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKK-LSKLAKPPLIVFVT 79
                         90       100
                 ....*....|....*....|.
gi 488218389  84 FKDeEYIREAFSIGVKGYLIK 104
Cdd:cd17532   80 AYD-EYAVEAFELNAVDYLLK 99
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
3-104 6.80e-15

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 70.58  E-value: 6.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKeIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI--LAKFPKAILLL 80
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTLG-YDVVTAES-GEEALELLLEAPPDLILLDVRMPGMDGFELLRLLraDPSTRDIPVIF 85
                         90       100
                 ....*....|....*....|....
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTK 109
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
1-104 7.36e-15

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 69.60  E-value: 7.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTkEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAIlLL 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREA-GYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPV-IL 80
                         90       100
                 ....*....|....*....|....
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:COG3707   81 LTAYSDPELIERALEAGVSAYLVK 104
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
1-104 8.10e-15

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 69.17  E-value: 8.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTK-EIRVLGIGHcakDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI--LAKFPKAI 77
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGyEVVEAADGE---EALELLQEHRPDLILLDLEMPDMDGLELCRRLraDPRTADIP 77
                         90       100
                 ....*....|....*....|....*..
gi 488218389  78 LLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:COG3706   78 IIFLTALDDEEDRARALEAGADDYLTK 104
PRK10360 PRK10360
transcriptional regulator UhpA;
1-201 1.09e-14

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 69.24  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIdaakEILAKFPKAILLL 80
Cdd:PRK10360   1 MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGL----ELLSQLPKGMATI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  81 LTTFKDE-EYIREAFSIGVKGYLIKQ-NLQAIIPSVKSAYNGQAVFGNEIIETFTQMMKNKPTidshayasfsERELAII 158
Cdd:PRK10360  77 MLSVHDSpALVEQALNAGARGFLSKRcSPDELIAAVHTVATGGCYLTPDIAIKLASGRQDPLT----------KRERQVA 146
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 488218389 159 KEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLA 201
Cdd:PRK10360 147 EKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVELA 189
GerE pfam00196
Bacterial regulatory proteins, luxR family;
148-204 1.53e-14

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 65.30  E-value: 1.53e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 488218389  148 ASFSERELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYF 204
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-78 4.39e-14

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 69.79  E-value: 4.39e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAIL 78
Cdd:PRK00742   3 KIRVLVVDDSAFMRRLISEILNSDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRPTPVV 80
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
2-111 7.20e-14

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 65.12  E-value: 7.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILEStKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMP-KQTGIDAAKEILAKFPKAIlLL 80
Cdd:cd17534    1 KKILIVEDEAIIALDLKEILES-LGYEVVGIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIREKFDIPV-IF 78
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK----QNLQAII 111
Cdd:cd17534   79 LTAYSDEETLERAKETNPYGYLVKpfneRELKAAI 113
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
1-195 9.96e-14

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 66.90  E-value: 9.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILEStKEIRVLGIgHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALER-EGYEVDTA-ADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK----QNLQAIIPSV-KSAYNGQAVFGNEIIETFTQMMKNKPTIDshayasFSEREL 155
Cdd:COG0745   79 LTARDDEEDRVRGLEAGADDYLTKpfdpEELLARIRALlRRRAAEVLRVGDLLDLAAREVTRDGEPVE------LTPKEF 152
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 488218389 156 AIIKEVAAGKNN----KEIADAL----YLSDGTVRNYISQLLEKLDLR 195
Cdd:COG0745  153 RLLELLMRNPGRvvsrEQLLEEVwgydYGDDRTVDVHISRLRKKLEDD 200
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
150-203 5.56e-13

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 61.01  E-value: 5.56e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488218389 150 FSERELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIY 203
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAY 54
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
149-207 2.14e-12

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 63.24  E-value: 2.14e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488218389 149 SFSERELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFYQH 207
Cdd:COG2771  127 GLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRL 185
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
1-104 1.12e-11

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 62.12  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI----LAKFPKA 76
Cdd:COG5801    4 KIKVLIADDNREFCELLEEYLSSQPDMEVVGVAYNGLEALELIEEKKPDVVILDIIMPHLDGLGVLEKLremnLEKRPKV 83
                         90       100
                 ....*....|....*....|....*...
gi 488218389  77 IllLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:COG5801   84 I--MLTAFGQEDITQRAVELGADYYILK 109
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
3-104 1.97e-11

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 58.61  E-value: 1.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEIRVLGIGhCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAIL--LL 80
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLEVVSFT-DPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDVpiVM 80
                         90       100
                 ....*....|....*....|....
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17551   81 ITADTDREVRLRALEAGATDFLTK 104
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
2-93 3.58e-11

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 58.18  E-value: 3.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILEStKEIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLL 81
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRR-EGYEVL-TATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILL 78
                         90
                 ....*....|..
gi 488218389  82 TTFKDEEYIREA 93
Cdd:cd17569   79 TGYADLDAAIEA 90
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
2-79 4.00e-11

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 61.05  E-value: 4.00e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILL 79
Cdd:PRK12555   1 MRIGIVNDSPLAVEALRRALARDPDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERPCPILI 78
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
4-104 5.80e-11

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 57.36  E-value: 5.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTT 83
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTV 80
                         90       100
                 ....*....|....*....|.
gi 488218389  84 FKDEEYIREAFSIGVKGYLIK 104
Cdd:cd19931   81 SDAEDDVVTALRAGADGYLLK 101
PRK11697 PRK11697
two-component system response regulator BtsR;
1-64 9.19e-11

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 59.09  E-value: 9.19e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488218389   1 MITVVIIDDDPFVTKSLQTILESTKEIRVlgIGHC--AKDALVLYETHRPDVLLTDIRMPKQTGID 64
Cdd:PRK11697   1 MIKVLIVDDEPLAREELRELLQEEGDIEI--VGECsnAIEAIGAIHRLKPDVVFLDIQMPRISGLE 64
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
3-117 3.51e-10

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 55.28  E-value: 3.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKeIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLEDSG-FQVLQAAD-GRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVS 79
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIK--QNLQAIIPSVKSA 117
Cdd:cd17555   80 GAGVMSDAVEALRLGAWDYLTKpiEDLAVLEHAVRRA 116
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
2-104 4.51e-10

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 54.92  E-value: 4.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI----LAKFPKAI 77
Cdd:cd17561    2 IKVLIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLrrmrLEKRPKII 81
                         90       100
                 ....*....|....*....|....*..
gi 488218389  78 llLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17561   82 --MLTAFGQEDITQRAVELGASYYILK 106
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
4-104 3.74e-09

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 52.47  E-value: 3.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILEStkeirvlgIGHCA------KDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKA- 76
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEK--------LGYEVdvaengQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGGGr 72
                         90       100       110
                 ....*....|....*....|....*....|
gi 488218389  77 --ILLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17546   73 rtPIIALTANALEEDREKCLEAGMDDYLSK 102
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
3-70 4.50e-09

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 52.25  E-value: 4.50e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEiRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQ-TGIDAAKEIL 70
Cdd:cd17540    2 RVLIIEDEPLIAMDLEQIVEDLGH-QVVGIARTRDEAVALARRERPDLILADIQLADGsSGIDAVNEIL 69
PRK09191 PRK09191
two-component response regulator; Provisional
4-74 5.50e-09

two-component response regulator; Provisional


Pssm-ID: 236402 [Multi-domain]  Cd Length: 261  Bit Score: 54.47  E-value: 5.50e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEiRVLGIGHCAKDALVLYETHRPDVLLTDIRM-PKQTGIDAAKEILAKFP 74
Cdd:PRK09191 140 VLIIEDEPIIAMDLEQLVESLGH-RVTGIARTRAEAVALAKKTRPGLILADIQLaDGSSGIDAVNDILKTFD 210
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
6-104 7.21e-09

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 51.25  E-value: 7.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   6 IIDDDPFVTKSLQTILEStKEIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTTFK 85
Cdd:cd17574    2 VVEDDEEIAELLSDYLEK-EGYEVD-TAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKD 79
                         90
                 ....*....|....*....
gi 488218389  86 DEEYIREAFSIGVKGYLIK 104
Cdd:cd17574   80 EEEDKVLGLELGADDYITK 98
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
4-111 7.63e-09

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 51.69  E-value: 7.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILEStKEIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI--LAKFPKAILLLL 81
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLEL-EGAEVT-TAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLreLPWLANTPAIAL 78
                         90       100       110
                 ....*....|....*....|....*....|....
gi 488218389  82 TTFKDEEYIREAFSIGVKGYLIK----QNLQAII 111
Cdd:cd17580   79 TGYGQPEDRERALEAGFDAHLVKpvdpDELIELI 112
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
161-201 8.66e-09

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 53.17  E-value: 8.66e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 488218389 161 VAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLA 201
Cdd:COG2909  134 LAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAV 174
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
47-104 1.15e-08

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 51.65  E-value: 1.15e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488218389  47 RPDVLLTDIRMPKQTGIDAAKEI-----LAKFPKAIlllLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17557   52 RPDLILLDLNMPRMDGFEVLREIkadpdLRRIPVVV---LTTSDAEEDIERAYELGANSYIVK 111
fixJ PRK09390
response regulator FixJ; Provisional
3-192 1.55e-08

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 52.70  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTK-EIRVLgigHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLL 81
Cdd:PRK09390   5 VVHVVDDDEAMRDSLAFLLDSAGfEVRLF---ESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVM 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  82 TTFKDEEYIREAFSIGVKGYLIKQ-NLQAIIPSVKSAyngqavfgneiIETFTQMMKNKPTIDSHA--YASFSERELAII 158
Cdd:PRK09390  82 TGHGDVPLAVEAMKLGAVDFIEKPfEDERLIGAIERA-----------LAQAPEAAKSEAVAADIRarIASLSERERQVM 150
                        170       180       190
                 ....*....|....*....|....*....|....
gi 488218389 159 KEVAAGKNNKEIADALYLSDGTVRNYISQLLEKL 192
Cdd:PRK09390 151 DGLVAGLSNKVIARDLDISPRTVEVYRANVMTKM 184
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
3-104 2.27e-08

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 50.83  E-value: 2.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILEstKEIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:cd17596    2 TILVVDDEVRSLEALRRTLE--EDFDVLTAAS-AEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIIS 78
                         90       100
                 ....*....|....*....|...
gi 488218389  83 TFKDEEYIREAFS-IGVKGYLIK 104
Cdd:cd17596   79 GYTDSEDIIAGINeAGIYQYLTK 101
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
3-104 3.33e-08

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 49.96  E-value: 3.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDpfvtKSLQTILE---STKEIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILL 79
Cdd:cd19919    2 TVWIVDDD----SSIRWVLEralAGAGLTVTSFEN-AQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVI 76
                         90       100
                 ....*....|....*....|....*
gi 488218389  80 LLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd19919   77 IMTAHSDLDSAVSAYQGGAFEYLPK 101
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
2-111 4.29e-08

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 52.34  E-value: 4.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKeiRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLL 81
Cdd:PRK10365   6 IDILVVDDDISHCTILQALLRGWG--YNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIM 83
                         90       100       110
                 ....*....|....*....|....*....|....
gi 488218389  82 TTFKDEEYIREAFSIGVKGYLIK----QNLQAII 111
Cdd:PRK10365  84 TAYSSVETAVEALKTGALDYLIKpldfDNLQATL 117
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
4-82 1.38e-07

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 48.64  E-value: 1.38e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218389   4 VVIIDDDPFVTKSLQTILEsTKEIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:cd17549    1 VLLVDDDADVREALQQTLE-LAGFRVRAFAD-AEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILIT 77
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
3-104 2.63e-07

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 48.76  E-value: 2.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKeIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:COG4567    6 SLLLVDDDEAFARVLARALERRG-FEVT-TAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83
                         90       100
                 ....*....|....*....|..
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIK 104
Cdd:COG4567   84 GYASIATAVEAIKLGADDYLAK 105
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
6-104 6.77e-07

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 46.11  E-value: 6.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   6 IIDDDPFVTKSLQTILESTKEIRVLGIG----HCAKDALVLyethRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLL 81
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLGEVVGEAdngaQAYDEILFL----QPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMI 78
                         90       100
                 ....*....|....*....|...
gi 488218389  82 TTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17565   79 SQVSDKEMIGKAYQAGIEFFINK 101
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
2-58 1.17e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 44.10  E-value: 1.17e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 488218389     2 ITVVIIDDDPFVTKSLQTILEStKEIRVlGIGHCAKDALVLYETHRPDVLLTDIRMP 58
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEK-EGYEV-DEATDGEEALELLKEEKPDLILLDIMMP 55
PRK10100 PRK10100
transcriptional regulator CsgD;
50-209 1.89e-06

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 46.79  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  50 VLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTTFKDEEYIREAFS----IGVkgYLIKQNLQAIIPSVKSAYNGQAVFG 125
Cdd:PRK10100  55 IILLDMMEADKKLIHYWQDTLSRKNNNIKILLLNTPEDYPYREIENwphiNGV--FYAMEDQERVVNGLQGVLRGECYFT 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389 126 NEIIEtFTQMMKNKPTIDSHAYASFSERELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIYFY 205
Cdd:PRK10100 133 QKLAS-YLITHSGNYRYNSTESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWAN 211

                 ....
gi 488218389 206 QHLQ 209
Cdd:PRK10100 212 DNLR 215
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
7-104 1.91e-06

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 45.40  E-value: 1.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   7 IDDDPFVTKSLQTILES--TKEIRVL--GIGHCAKDALV-LYETHRP-DVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:cd17595    6 VDDDPQVLRAVARDLRRqyGKDYRVLraDSGAEALDALKeLKLRGEAvALFLVDQRMPEMDGVEFLEKAMELFPEAKRVL 85
                         90       100
                 ....*....|....*....|....*
gi 488218389  81 LTTFKDEEY-IREAFSIGVKGYLIK 104
Cdd:cd17595   86 LTAYADTDAaIRAINDVQLDYYLLK 110
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
3-104 4.87e-06

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 44.13  E-value: 4.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTkeirvlgiGH---CAKD---ALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKA 76
Cdd:cd17554    2 KILVVDDEENIRELYKEELEDE--------GYevvTAGNgeeALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDL 73
                         90       100
                 ....*....|....*....|....*...
gi 488218389  77 ILLLLTTFkdEEYIREAFSIGVKGYLIK 104
Cdd:cd17554   74 PVIICTAY--SEYKSDFSSWAADAYVVK 99
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
4-74 5.03e-06

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 44.02  E-value: 5.03e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488218389   4 VVIIDDDPFVTKSLQTILEStkEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFP 74
Cdd:cd17550    1 ILIVDDEEDIRESLSGILED--EGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYP 69
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
3-104 5.42e-06

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 43.83  E-value: 5.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEIRVLGIGhcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI--LAKFPKAILLL 80
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEVVEAAD--GRDALSKAQSKKFDLIITDQNMPNMDGIELIKELrkLPAYKFTPILM 79
                         90       100
                 ....*....|....*....|....
gi 488218389  81 LTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17562   80 LTTESSDEKKQEGKAAGATGWLVK 103
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
3-80 5.60e-06

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 43.97  E-value: 5.60e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI-LAKFPKAILLL 80
Cdd:cd17530    2 RVLVLDDDPFQCMMAATILEDLGPGNVDEADD-GREALVILLCNAPDIIICDLKMPDMDGIEFLRHLaESHSNAAVILM 79
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
4-84 9.81e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 42.72  E-value: 9.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILEStkeirvLG----IGHCAKDALVLYETH-RPDVLLTDIRMP-KQTGIDAAKEILAKFPKAI 77
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLED------LGytvlEAASGDEALDLLESGpDIDLLVTDVIMPgGMNGSQLAEEARRRRPDLK 74

                 ....*..
gi 488218389  78 LLLLTTF 84
Cdd:cd18161   75 VLLTSGY 81
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
3-82 9.95e-06

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 43.20  E-value: 9.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILEsTKEIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:cd17563    2 SLLLVDDDEVFAERLARALE-RRGFEVE-TAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT 79
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
4-104 1.07e-05

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 43.14  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILE-STKEIRVLGIGhcaKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRfEGYEVETAVDG---AEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLT 77
                         90       100
                 ....*....|....*....|...
gi 488218389  83 TfKDEEYIR-EAFSIGVKGYLIK 104
Cdd:cd17627   78 A-RDSVSDRvAGLDAGADDYLVK 99
PRK13557 PRK13557
histidine kinase; Provisional
3-83 1.51e-05

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 45.05  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKeIRVLgIGHCAKDALVLYETH-RPDVLLTDIRMP-KQTGIDAAKEILAKFPKaILLL 80
Cdd:PRK13557 417 TILIVDDRPDVAELARMILEDFG-YRTL-VASNGREALEILDSHpEVDLLFTDLIMPgGMNGVMLAREARRRQPK-IKVL 493

                 ...
gi 488218389  81 LTT 83
Cdd:PRK13557 494 LTT 496
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
4-104 1.54e-05

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 42.80  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILesTKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLltT 83
Cdd:cd17614    1 ILVVDDEKPISDILKFNL--TKEGYEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIML--T 76
                         90       100
                 ....*....|....*....|..
gi 488218389  84 FKDEEYIRE-AFSIGVKGYLIK 104
Cdd:cd17614   77 AKDSEVDKVlGLELGADDYVTK 98
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
4-104 1.75e-05

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 42.15  E-value: 1.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILEsTKEIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEiLAKFPKAILLLLTT 83
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALE-AHGYRVF-EAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRR-LREWSAVPVIVLSA 77
                         90       100
                 ....*....|....*....|.
gi 488218389  84 FKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17620   78 RDEESDKIAALDAGADDYLTK 98
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
4-104 2.18e-05

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 44.48  E-value: 2.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDpfvtKSLQTILEstkeiRVL-GIG-HC-----AKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKA 76
Cdd:PRK10923   6 VWVVDDD----SSIRWVLE-----RALaGAGlTCttfenGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPML 76
                         90       100
                 ....*....|....*....|....*...
gi 488218389  77 ILLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:PRK10923  77 PVIIMTAHSDLDAAVSAYQQGAFDYLPK 104
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
3-71 4.07e-05

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 41.43  E-value: 4.07e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488218389   3 TVVIIDDDPFVTKSLQTILEStkeirvLGIG----HCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILA 71
Cdd:cd17537    2 TVYVVDDDEAVRDSLAFLLRS------VGLAvktfTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLA 68
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-80 9.23e-05

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 42.10  E-value: 9.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKSLQTILEstKEIRVLGIGHCAKDALVLYEThRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:PRK10955   1 MNKILLVDDDRELTSLLKELLE--MEGFNVIVAHDGEQALDLLDD-SIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIML 77
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
4-80 1.06e-04

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 40.37  E-value: 1.06e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488218389   4 VVIIDDDPFVTKSLQTILESTK-EIRVLgigHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLL 80
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGfNVRAA---HDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKTSQVPVLML 75
PRK10188 PRK10188
transcriptional regulator SdiA;
150-203 1.23e-04

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 41.69  E-value: 1.23e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488218389 150 FSERELAIIKEVAAGKNNKEIADALYLSDGTVRNYISQLLEKLDLRDRTQLAIY 203
Cdd:PRK10188 180 FSKREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPNKTQIACY 233
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
4-105 1.85e-04

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 39.44  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTKEIRVLGIGhcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLTT 83
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLDVRSARN--VKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITA 78
                         90       100
                 ....*....|....*....|..
gi 488218389  84 FKDEEYIREAFSIGVKGYLIKQ 105
Cdd:cd19926   79 YGSLDTAIEALKAGAFDFLTKP 100
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
3-104 2.61e-04

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 39.06  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILEStKEIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI-----LAKFPkai 77
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLES-AGYEVLEAAD-GEEALEIARKEKPDLILMDIQLPGMDGLEATRLLkedpaTRDIP--- 75
                         90       100       110
                 ....*....|....*....|....*....|
gi 488218389  78 LLLLTTFK---DEEYIREAfsiGVKGYLIK 104
Cdd:cd17548   76 VIALTAYAmkgDREKILEA---GCDGYISK 102
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
3-69 3.53e-04

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 38.63  E-value: 3.53e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488218389   3 TVVIIDDDPFVTKSLQTILEStKEIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI 69
Cdd:cd17538    1 KILVVDDEPANRELLEALLSA-EGYEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRL 65
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
4-104 5.15e-04

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 38.51  E-value: 5.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTK-EIRVLGIGHCAKDALvlyETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:cd17622    3 ILLVEDDPKLARLIADFLESHGfNVVVEHRGDRALEVI---AREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLTA 79
                         90       100
                 ....*....|....*....|..
gi 488218389  83 TFKDEEYIReAFSIGVKGYLIK 104
Cdd:cd17622   80 LDSDIDHIL-GLELGADDYVVK 100
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
4-104 7.30e-04

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 37.74  E-value: 7.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTK-EIRVLGIGhcaKDALVLYE---------THRPDVLLTDIRMPKQTGIDAAKEILA-- 71
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGfEIAEAVDG---EEALNKLEnlakegndlSKELDLIITDIEMPKMDGYELTFELRDdp 77
                         90       100       110
                 ....*....|....*....|....*....|...
gi 488218389  72 KFPKAILLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd19924   78 RLANIPVILNSSLSGEFSRARGKKVGADAYLAK 110
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
4-104 8.25e-04

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 37.69  E-value: 8.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTK-EIRVLGIGhcaKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI-----LAKFPkai 77
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGyKVQVARNG---REALAMLAEHRPTLVISDIVMPEMDGYELCRKIksdpdLKDIP--- 74
                         90       100
                 ....*....|....*....|....*..
gi 488218389  78 LLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17598   75 VILLTTLSDPRDVIRGLECGADNFITK 101
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
2-104 8.55e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 37.70  E-value: 8.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILestkeiRVLGIGHCA-----KDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILA--KFP 74
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLL------KELGFNNVEeaedgVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRAdgALS 74
                         90       100       110
                 ....*....|....*....|....*....|
gi 488218389  75 KAILLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd19923   75 HLPVLMVTAEAKKENVIAAAQAGVNNYIVK 104
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
2-104 1.30e-03

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 37.39  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKEIrvlGIGHCAK--DALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKA--I 77
Cdd:cd17575    1 IMVLLVDDQAIIGEAVRRALADEEDI---DFHYCSDptEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANPATRdiP 77
                         90       100
                 ....*....|....*....|....*..
gi 488218389  78 LLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17575   78 IIVLSTKEEPEVKSEAFALGANDYLVK 104
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
4-104 1.35e-03

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 36.97  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILEStKEIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI-----LAKFPkaIL 78
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLED-QGFTVI-AASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLrknadFDTIP--VI 76
                         90       100
                 ....*....|....*....|....*.
gi 488218389  79 LLLTTFKDEEYIReAFSIGVKGYLIK 104
Cdd:cd19927   77 FLTAKGMTSDRIK-GYNAGCDGYLSK 101
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
3-96 1.54e-03

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 36.95  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTK-EIRVLGIGHcakDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLL 81
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRYEGwDVETAADGA---EALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFL 77
                         90       100
                 ....*....|....*....|....*..
gi 488218389  82 T------------TFKDEEYIREAFSI 96
Cdd:cd17615   78 TakdsvedriaglTAGGDDYVTKPFSL 104
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
3-104 1.63e-03

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 36.84  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILEStKEIRVLGIGHcAKDALVLYETHRPDVLLTDIRMPKQTGIDAAK-----EILAKFPkai 77
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLER-AGFDVVEAED-AESAVNLIVEPRPDLILLDWMLPGGSGIQFIRrlkrdEMTRDIP--- 76
                         90       100
                 ....*....|....*....|....*..
gi 488218389  78 LLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17618   77 IIMLTARGEEEDKVRGLEAGADDYITK 103
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
2-181 1.73e-03

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 38.28  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   2 ITVVIIDDDPFVTKSLQTILESTKEIRVLGIghcAKDALVLYETH---RPDVLLTDIRMPKQT---GIDAAKEILAKFPK 75
Cdd:PRK10840   4 MNVIIADDHPIVLFGIRKSLEQIEWVNVVGE---FEDSTALINNLpklDAHVLITDLSMPGDKygdGITLIKYIKRHFPS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389  76 AILLLLTTFKDEEYIREAFSIGVKGYLIKQNLQAIIPSVKSAYNGQAVFgneIIETFTQMMKnKPTIDSHAYASFSEREL 155
Cdd:PRK10840  81 LSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKF---TPESVSRLLE-KISAGGYGDKRLSPKES 156
                        170       180
                 ....*....|....*....|....*.
gi 488218389 156 AIIKEVAAGKNNKEIADALYLSDGTV 181
Cdd:PRK10840 157 EVLRLFAEGFLVTEIAKKLNRSIKTI 182
PRK10430 PRK10430
two-component system response regulator DcuR;
1-104 2.20e-03

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 37.78  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   1 MITVVIIDDDPFVTKslqtiLESTKEIRVLGIGHC--------AKDALVLYETHrPDVLLTDIRMPKQTGIDAAKEILAK 72
Cdd:PRK10430   1 MINVLIVDDDAMVAE-----LNRRYVAQIPGFQCCgtastleqAKEIIFNSDTP-IDLILLDIYMQQENGLDLLPVLHEA 74
                         90       100       110
                 ....*....|....*....|....*....|..
gi 488218389  73 FPKAILLLLTTFKDEEYIREAFSIGVKGYLIK 104
Cdd:PRK10430  75 GCKSDVIVISSAADAATIKDSLHYGVVDYLIK 106
PRK10693 PRK10693
two-component system response regulator RssB;
34-104 3.11e-03

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 37.66  E-value: 3.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488218389  34 HCA---KDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAK---FPkaILLLLTTFKDEEyIREAFSIGVKGYLIK 104
Cdd:PRK10693   1 VLAangVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRgdqTP--VLVISATENMAD-IAKALRLGVQDVLLK 74
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
4-104 3.94e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 35.99  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   4 VVIIDDDPFVTKSLQTILESTK--EIRVLGIGhcaKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKfP--KAILL 79
Cdd:cd17552    4 ILVIDDEEDIREVVQACLEKLAgwEVLTASSG---QEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQAN-PetQSIPV 79
                         90       100
                 ....*....|....*....|....*.
gi 488218389  80 LLTTFKDEEYIREAF-SIGVKGYLIK 104
Cdd:cd17552   80 ILLTAKAQPSDRQRFaSLGVAGVIAK 105
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
3-104 4.08e-03

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 35.89  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILESTKEIrVLGIGHCAKDALVLYEtHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:cd17594    1 HVLVVDDDAAMRHLLILYLRERGFD-VTAAADGAEEARLMLH-RRVDLVLLDLRLGQESGLDLLRTIRARSDVPIIIISG 78
                         90       100
                 ....*....|....*....|..
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd17594   79 DRRDEIDRVVGLELGADDYLAK 100
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
4-69 8.63e-03

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 34.87  E-value: 8.63e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488218389   4 VVIIDDDPFVTKSLQTILeSTKEIRVLgIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEI 69
Cdd:cd17572    1 VLLVEDSPSLAALYQEYL-SDEGYKVT-HVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWI 64
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
3-104 9.51e-03

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 34.40  E-value: 9.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488218389   3 TVVIIDDDPFVTKSLQTILEStKEIRVLGIGHCAKDALVLYETHRPDVLLTDIRMPKQTGIDAAKEILAKFPKAILLLLT 82
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKK-AGYAVTEAESGAEALEKLQQGKDIDIVVTDIVMPEMDGIELAREARKIDPDVKILFIS 79
                         90       100
                 ....*....|....*....|..
gi 488218389  83 TFKDEEYIREAFSIGVKGYLIK 104
Cdd:cd18160   80 GGAAAAPELLSDAVGDNATLKK 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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