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Conserved domains on  [gi|488220203|ref|WP_002291411|]
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MULTISPECIES: galactokinase [Enterococcus]

Protein Classification

galactokinase( domain architecture ID 11480725)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  3.30.230.10|3.30.70.890
EC:  2.7.1.6
Gene Ontology:  GO:0046835|GO:0006012|GO:0005534|GO:0004335|GO:0005524
PubMed:  15526155|26862196
SCOP:  4000959|4001389

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05322 PRK05322
galactokinase; Provisional
 4-388 0e+00

galactokinase; Provisional


:

Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 666.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   4 KRSLNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDDIGVISFTLDE 83
Cdd:PRK05322   3 KEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIIEFDLDD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  84 LEYDKKANWANYVKGMVLKLKEAGHPIDHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVE 163
Cdd:PRK05322  83 LSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 164 NEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYEMVPVKLDGYAIVIMNTNKRRELADSKYNERRSECEEALARLQKTL 243
Cdd:PRK05322 163 NEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKKL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 244 PISSLGDLDEEEFESTIDQIGDDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIELDTLV 323
Cdd:PRK05322 243 DIKSLGELTEEEFDEYSYLIKDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTLV 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488220203 324 DAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNGTTKI 388
Cdd:PRK05322 323 EAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
 
Name Accession Description Interval E-value
PRK05322 PRK05322
galactokinase; Provisional
 4-388 0e+00

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 666.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   4 KRSLNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDDIGVISFTLDE 83
Cdd:PRK05322   3 KEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIIEFDLDD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  84 LEYDKKANWANYVKGMVLKLKEAGHPIDHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVE 163
Cdd:PRK05322  83 LSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 164 NEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYEMVPVKLDGYAIVIMNTNKRRELADSKYNERRSECEEALARLQKTL 243
Cdd:PRK05322 163 NEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKKL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 244 PISSLGDLDEEEFESTIDQIGDDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIELDTLV 323
Cdd:PRK05322 243 DIKSLGELTEEEFDEYSYLIKDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTLV 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488220203 324 DAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNGTTKI 388
Cdd:PRK05322 323 EAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
4-389 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 544.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   4 KRSLNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDDIgvISFTLDE 83
Cdd:COG0153    2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEE--VEFDLDD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  84 LEYDKKANWANYVKGMVLKLKEAGHPIdHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVE 163
Cdd:COG0153   80 LEPGEEDGWANYVRGVAWALQERGYKL-GGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 164 NEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYEMVPVKLDGYAIVIMNTNKRRELADSKYNERRSECEEALARLQktl 243
Cdd:COG0153  159 NEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILG--- 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 244 pISSLGDLDEEEFESTIDQIGDDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIELDTLV 323
Cdd:COG0153  236 -VKSLRDVTLEDLEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLV 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488220203 324 DAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNGTTKID 389
Cdd:COG0153  315 ELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRLA 380
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 4-384 3.37e-125

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 366.46  E-value: 3.37e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203    4 KRSLNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDDiGVISFTLDe 83
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADN-KFAERSLD- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   84 LEYDKKAN--WANYVKGMVLKLKEAGHPIDHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKK 161
Cdd:TIGR00131  79 LPLDGSEVsdWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  162 VENEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYEMVPVKLDGYAIVIMNTNKRRELADSKYNERRSECEEALARLQK 241
Cdd:TIGR00131 159 AENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  242 TlPISSLGDLDEEEFESTIDQIG--DDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIEL 319
Cdd:TIGR00131 239 T-DKGALRDFMNEYFARYIARLTkmLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEI 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488220203  320 DTLVDAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNG 384
Cdd:TIGR00131 318 DELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPG 382
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 9-58 5.54e-18

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 77.11  E-value: 5.54e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 488220203    9 TKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAP 58
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PRK05322 PRK05322
galactokinase; Provisional
 4-388 0e+00

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 666.95  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   4 KRSLNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDDIGVISFTLDE 83
Cdd:PRK05322   3 KEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEDLGIIEFDLDD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  84 LEYDKKANWANYVKGMVLKLKEAGHPIDHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVE 163
Cdd:PRK05322  83 LSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 164 NEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYEMVPVKLDGYAIVIMNTNKRRELADSKYNERRSECEEALARLQKTL 243
Cdd:PRK05322 163 NEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKKL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 244 PISSLGDLDEEEFESTIDQIGDDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIELDTLV 323
Cdd:PRK05322 243 DIKSLGELTEEEFDEYSYLIKDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTLV 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488220203 324 DAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNGTTKI 388
Cdd:PRK05322 323 EAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
4-389 0e+00

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 544.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   4 KRSLNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDDIgvISFTLDE 83
Cdd:COG0153    2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEE--VEFDLDD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  84 LEYDKKANWANYVKGMVLKLKEAGHPIdHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVE 163
Cdd:COG0153   80 LEPGEEDGWANYVRGVAWALQERGYKL-GGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 164 NEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYEMVPVKLDGYAIVIMNTNKRRELADSKYNERRSECEEALARLQktl 243
Cdd:COG0153  159 NEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAILG--- 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 244 pISSLGDLDEEEFESTIDQIGDDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIELDTLV 323
Cdd:COG0153  236 -VKSLRDVTLEDLEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLV 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488220203 324 DAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNGTTKID 389
Cdd:COG0153  315 ELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRLA 380
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 4-384 3.37e-125

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 366.46  E-value: 3.37e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203    4 KRSLNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDDiGVISFTLDe 83
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADN-KFAERSLD- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   84 LEYDKKAN--WANYVKGMVLKLKEAGHPIDHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKK 161
Cdd:TIGR00131  79 LPLDGSEVsdWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  162 VENEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYEMVPVKLDGYAIVIMNTNKRRELADSKYNERRSECEEALARLQK 241
Cdd:TIGR00131 159 AENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  242 TlPISSLGDLDEEEFESTIDQIG--DDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIEL 319
Cdd:TIGR00131 239 T-DKGALRDFMNEYFARYIARLTkmLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEI 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488220203  320 DTLVDAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNG 384
Cdd:TIGR00131 318 DELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPG 382
PRK05101 PRK05101
galactokinase; Provisional
 1-384 3.83e-114

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 338.05  E-value: 3.83e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   1 MEIKRSLNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDDiGVISFT 80
Cdd:PRK05101   1 MSLKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDN-QQDEFS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  81 LDE-LEYDKKANWANYVKGMVLKLKEAGHPIdHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTG 159
Cdd:PRK05101  80 LDApIVPHPEQQWANYVRGVVKHLQERNPDF-GGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 160 KKVENEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYEMVPVkLDGYAIVIMNTNKRRELADSKYNERRSECEEAlARL 239
Cdd:PRK05101 159 QEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM-PEGVAVVIINSNVKRGLVDSEYNTRRQQCETA-ARF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 240 qktLPISSLGDLDEEEFESTIDQIgDDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIEL 319
Cdd:PRK05101 237 ---FGVKALRDVTLEQFNAVAAEL-DPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQI 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488220203 320 DTLVDAAQ----KQAGVlgaRMTGAGFGGCAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNG 384
Cdd:PRK05101 313 DTLVEIVKavigDQGGV---RMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQG 378
PRK03817 PRK03817
galactokinase; Provisional
 25-389 1.19e-105

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 315.40  E-value: 1.19e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  25 SPGRINLIGEHTDYNGGHVFPASITYGTqgVAAPRDDNKILVYSTNFDDigVISFTLDELEydKKANWANYVKGMVLKLK 104
Cdd:PRK03817   5 SPGRVNLIGEHTDYNDGYVLPFAINLYT--FLEIEKSEKFIFYSENFNE--EKTFELDKLE--KLNSWADYIKGVIWVLE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 105 EAGHPIDhGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVENEFIGVNSGIMDQFAIGFGEL 184
Cdd:PRK03817  79 KRGYEVG-GVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFGKK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 185 DHAILLDTNTLKYEMVPVKlDGYAIVIMNTNKRRELADSKYNERRSECEEALARLQKtlpiSSLGDLDEEEFESTidqig 264
Cdd:PRK03817 158 DHAIFLDTMTLEYEYVPFP-EDYEILVFDTGVKRELASSEYNERRQECEEALKILGK----KSSKEVTEEDLSKL----- 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 265 DDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIELDTLVDAAqKQAGVLGARMTGAGFGG 344
Cdd:PRK03817 228 PPLLRKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFA-LELGAYGARLTGAGFGG 306

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 488220203 345 CAIALVKEENIPAFKNNVYDEYMKVVGYAPEFYVAHIGNGTTKID 389
Cdd:PRK03817 307 SAIALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGVRKIE 351
PRK00555 PRK00555
galactokinase; Provisional
 20-353 1.53e-73

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 233.60  E-value: 1.53e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  20 TTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDdiGVISFTLDELEYDKKAnWANYVKGM 99
Cdd:PRK00555   2 TVRYAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRAD--GSARIPLDTTPGQVTG-WAAYAAGV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 100 VLKLKEAGHPIDHGfELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVENEFIGVNSGIMDQFAI 179
Cdd:PRK00555  79 IWALRGAGHPVPGG-AMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 180 GFGELDHAILLDTNTLKYEMVPVKLD--GYAIVIMNTNKRRELADSKYNERRSECEEALARLQktlpISSLGDLDEEEFe 257
Cdd:PRK00555 158 LFGAPKTALLIDFRDLTVRPVAFDPDaaGVVLLLMDSRARHRHAGGEYAARRASCERAAADLG----VSSLRAVQDRGL- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 258 STIDQIGDDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTGIELDTLVDAAQKqAGVLGARM 337
Cdd:PRK00555 233 AALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVR-AGALGARM 311

                        330
                 ....*....|....*.
gi 488220203 338 TGAGFGGCAIALVKEE 353
Cdd:PRK00555 312 TGGGFGGCVIALVPAD 327
PLN02865 PLN02865
galactokinase
 25-368 7.74e-49

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 170.75  E-value: 7.74e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  25 SPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDdiGVISFTLDELEY---------DKKANWANY 95
Cdd:PLN02865  35 SPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFE--GEVRFRVDEIQHpianvssdsKEESNWGDY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  96 VKGMVLKLKEAGHPIDHGFEllveGTIPNGAGLSSS-ASLELLVGVV----LEDLFDLKTDRLELVQTGKKVENEFIGVN 170
Cdd:PLN02865 113 ARGAVYALQSRGHALSQGIT----GYISGSEGLDSSgLSSSAAVGVAyllaLENANNLTVSPEDNIELDRLIENEYLGLR 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 171 SGIMDQFAIGFGELDHAILLDTNTLKYEMVPVKLDG------YAIVIMNTNKRRELAD-SKYNERRSECEEAlARL---- 239
Cdd:PLN02865 189 NGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpFKILLAFSGLRHALTNkPGYNLRVSECQEA-ARFllea 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 240 ---QKTLPIssLGDLDEEEFESTIDQIgDDTLIRRARHAVYENQRTLKAKAELEAGNLEAFGQLLNDSHHSLRYDYEVTG 316
Cdd:PLN02865 268 sgnDELEPL--LCNVEPEVYEAHKCKL-EAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSIENYECGC 344

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488220203 317 IELDTLVDAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMK 368
Cdd:PLN02865 345 EPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEK 396
PLN02521 PLN02521
galactokinase
 7-368 1.93e-47

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 168.73  E-value: 1.93e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   7 LNTKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQgVAAPRDD--NKILVYSTNfDDIGVISFTLD-E 83
Cdd:PLN02521  35 LKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTI-VAIRRAEgsKKLRIANVN-DKYTTCTFPADpD 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  84 LEYD-KKANWANYV----KGMVLKLKEAGH--PIDHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELV 156
Cdd:PLN02521 113 QEVDlANHKWGNYFicgyKGVFEFLKSKGVdvGPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 157 QTGKKVEnEFIGVNSGIMDQfAIG-FGELDHAILLDTNTLKyeMVPVKL-DGYAIVIMNT---NKRRELADSKYNERRSE 231
Cdd:PLN02521 193 QFTCKCE-RHIGTQSGGMDQ-AISiMAQQGVAKLIDFNPVR--ATDVQLpAGGTFVIANSlaeSNKAVTAATNYNNRVVE 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 232 C---------------EEALARLqKTL------------------PISSLGDLDEEEFEST--IDQIGDDT--------- 267
Cdd:PLN02521 269 CrlaaivlavklgmsaEEAISKV-KTLsdveglcvsfagshgssdPAVAVKELLHEGPYTAeeIEEILGESltsifknsp 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 268 -------------LIRRARHAVYENQRTLKAKAELEAG-----NLEAFGQLLNDSHHSLRYDYEVTGIELDTLVDAAqKQ 329
Cdd:PLN02521 348 tslavlkaakhfkLHQRAVHVYSEAKRVHAFRDTVSSSlseeeKLKKLGDLMNESHYSCSVLYECSCPELEELVKVC-RD 426

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 488220203 330 AGVLGARMTGAGFGGCAIALVKEENIPAFKNNVYDEYMK 368
Cdd:PLN02521 427 NGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYK 465
PTZ00290 PTZ00290
galactokinase; Provisional
 24-384 4.04e-41

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 151.13  E-value: 4.04e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  24 FSPGRINLIGEHTDYNGGHVFPASITYGTQ---GVAAPRDDNKiLVYSTNFDDigviSFTLDEL-EYDKKANWANYVKG- 98
Cdd:PTZ00290  41 FAPGRVNFIGEHVDYMGGYVCPAAVLEGCHilvGRVKHFCDHK-LRFATETDE----HFVLDHLgGAKHNKAWTTFVRGa 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  99 MVLKLKEAGHPID----HGFELLVEGTIPNGAGlsssASLELLVGVVLEDLFDL------------------------KT 150
Cdd:PTZ00290 116 ATLRLNRLGVAIDapslQGVCMVVHGTLPMGAG----MSASASFGVALLNAINTvvtrrykgcptspgrrysilppmsKE 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 151 DRLELVQTGKKVENEFIGVNSGIMDQFAIGFGELDHAILLDTNTLKYE---MVPVKLDGYAIVIMNTNKRRELADSK--- 224
Cdd:PTZ00290 192 ELIELAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFEshdMTPLLGDGACFLLIDSMIKHDLLGGTagm 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 225 YNERRSECEEALARLQKTL--------------PISSLGDLDEEEFESTIDQIGDDTLIRRARHAVYENQRTLK----AK 286
Cdd:PTZ00290 272 YNTVRSDQEGAQKKIGKHRyrgkpftfsdlvrnPKKYTFDGDVVAFMESCKPLMTPGEFERGTYNIMEQIRTLEfiklND 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 287 AELEAGNLEAF---GQLLNDSHHSLRYDYEVTGIELDTLVDAAQKQAGVLGARMTGAGFGGCAIALVKEENIPAFKNNVY 363
Cdd:PTZ00290 352 PELPLSREERFrkaGEILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVR 431

                        410       420
                 ....*....|....*....|.
gi 488220203 364 DEYMKVVGYAPEFYVAHIGNG 384
Cdd:PTZ00290 432 EKFKARFGVENDVYPVVAGDG 452
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 25-350 6.76e-23

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 97.22  E-value: 6.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  25 SPGRINLIGEHTDYNGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDdigvISFTLDELEYDKKAnwanYVKGMVLKLK 104
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLG----GTLDLDPLADAALR----YIKAAIEAAL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 105 EAGHPIDHGFELLVEGTIPNGAGlsssaslellVG-----VV-----LEDLFDLKTDRLELVQTGKKVENEFIGVNSGiM 174
Cdd:COG1577   73 EYLGLPLKGFDIEIDSEIPRKRG----------LGssaavAVaviraLAAFYGVELSKEELFKLALEAEKIVHGNPSG-L 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 175 DQFAIGFGeldHAILLDTNTlKYEMVPVKLDGYAIVImntnkrreladskYNERRSECEEALARLQKtlpissLGDLDEE 254
Cdd:COG1577  142 DTAASTYG---GPIYYQRGD-RAEPLELPKNLPLVVG-------------DTGVPASTKELVAKVRK------LKERNPE 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 255 EFESTIDQIGDdtLIRRARHAvyenqrtlkakaeLEAGNLEAFGQLLNDSHHsLRYDYEVTGIELDTLVDAAQKqAGVLG 334
Cdd:COG1577  199 LYEAFLEEIGD--LVEEAIEA-------------LEEGDLEALGELMNENHG-LLRALGVSTPELDRLVEAARK-AGALG 261

                        330
                 ....*....|....*.
gi 488220203 335 ARMTGAGFGGCAIALV 350
Cdd:COG1577  262 AKLTGAGGGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 25-349 1.31e-22

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 96.21  E-value: 1.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203   25 SPGRINLIGEHtdyngghvfpaSITYGTQGVAAPRDDNKILVYSTNFDDIGVISFTLDELEYDKKANWANYVKGMVLKLK 104
Cdd:TIGR00549   1 APGKIILFGEH-----------AVVYGEPAIAAPIPLRTTVTVIESSDGSFIESDLGRGSLDDAPDELDGLKYVLAEFLS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  105 EAGHPIDHGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVENEFIGVNSGImDQFAIGFGel 184
Cdd:TIGR00549  70 RFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATSTSG-- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  185 dHAILLDTNTLKYEMVPvKLDGYaIVIMNTnkrRELADSKynerrseceEALARlqktlpISSLGDLDEEEFESTIDQIG 264
Cdd:TIGR00549 147 -GPVYFEKGEGEFTKLI-SLDGY-FVIADT---GVSGSTK---------EAVAR------VRQLLERFPELIDSIMDAIG 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  265 ddtlirrarhavyenQRTLKAKAELEAGNLEAFGQLLNDSH---HSLRydyeVTGIELDTLVDAAQKqAGVLGARMTGAG 341
Cdd:TIGR00549 206 ---------------ELTLEAKAALQDGDVESLGELMNINQgllKALG----VSHPKLDQLVEIARK-AGALGAKLTGAG 265


                  ....*...
gi 488220203  342 FGGCAIAL 349
Cdd:TIGR00549 266 GGGCMIAL 273
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 9-58 5.54e-18

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 77.11  E-value: 5.54e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 488220203    9 TKFAETFGPKKTTQYFSPGRINLIGEHTDYNGGHVFPASITYGTQGVAAP 58
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 25-359 2.55e-14

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 73.29  E-value: 2.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  25 SPGRINLIGEHTDY------NGGHVFPASITYGTQGVAAPRDDNKILVYSTNFDdigvISFTLDELEYDKKAnwanyvkg 98
Cdd:COG2605    5 APLRISFAGGGTDLppyyleHGGAVLNAAIDKYAYVTLEPRFDGKIRLSSSDTE----RVETVDEDDDIPHP-------- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  99 mVLK--LKEAGhpIDHGFELLVEGTIPNGAGlsssaslellVGVV--LEDLFDLKTDRLELVQTGKKVENEFIGVNSGIM 174
Cdd:COG2605   73 -VIReaLKLFG--IGDGLEITTDSDAPAGSGlgss--saltVALLnaLHALLGLPLSPYDLARLAYEIERNDLGEPGGKQ 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 175 DQFAIGFGELDHAILLDTNTLKYEMVPVKLDGYA-----IVIMNTNKRRELAD------SKYNERRSECEEALARLQktl 243
Cdd:COG2605  148 DQYAAAFGGFNFIEFGPDGRVIVNPLRISPEILNelesnLLLFYTGITRESSDilkeqvKNVEDGDEATLEALHEMK--- 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 244 pisslgdldeeefestidqigddtlirrarhavyenQRTLKAKAELEAGNLEAFGQLLNDS-HHSLRYDYEVTGIELDTL 322
Cdd:COG2605  225 ------------------------------------ELALEMKEALLKGDLDEFGELLNEGwELKKRLASGISNPAIDEI 268

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 488220203 323 VDAAqKQAGVLGARMTGAGFGGCAIALVKEENIPAFK 359
Cdd:COG2605  269 YELA-RKAGALGGKLLGAGGGGFLLFYAPPERREAVR 304
PRK03926 PRK03926
mevalonate kinase; Provisional
 25-355 3.24e-12

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 66.62  E-value: 3.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203  25 SPGRINLIGEHtdyngghvfpaSITYGTQGVAAPRDDNKILVYSTNFDDIGVISftldelEYDKKANWANYVKGMVLKLK 104
Cdd:PRK03926   6 APGKIYLFGEH-----------AVVYGKPAIACAIDLRTYVRAEFNDDSIYIES------DYGKTGEKHPYVSAAIEKMR 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 105 EAGhPIDhGFELLVEGTIPNGAGLSSSASLELLVGVVLEDLFDLKTDRLELVQTGKKVENEFIGVNSGImDQFAIGFGEL 184
Cdd:PRK03926  69 EEA-DKD-GVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVSTMGGF 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 185 DHaiLLDTNTLKYEMVPvkldgyaIVIMNTNKrreladskyNERRSECEEALARLQKTLPisslgdldeEEFESTIDQIG 264
Cdd:PRK03926 146 VT--IPDRKKLPFPECG-------IVVGYTGS---------SGSTKELVANVRKLKEEYP---------ELIEPILSSIG 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 265 DdtlirrarhavyenqRTLKAKAELEAGNLEAFGQLLNdSHHSLRYDYEVTGIELDTLVDAAqKQAGVLGARMTGAGFGG 344
Cdd:PRK03926 199 K---------------ISEKGEELILSGDYVSLGELMN-INQGLLDALGVSTKELSELIYAA-RTAGALGAKITGAGGGG 261

                        330
                 ....*....|.
gi 488220203 345 CAIALVKEENI 355
Cdd:PRK03926 262 CMVALAAPEKQ 272
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 285-353 8.95e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 55.17  E-value: 8.95e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488220203  285 AKAELEAGNLEAFGQLLNDSHHSLRyDYEVTGI---ELDTLVDAAqKQAGvLGARMTGAGFGGCAIALVKEE 353
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLE-PLLVVGIlppELDELLEAL-LELG-LGAKLSGSGGGPTVFALFKDE 69
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 284-353 7.95e-07

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 50.62  E-value: 7.95e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488220203 284 KAKAELEAGNLEAFGQLLNdSHHSLRYDYEVTGIELDTLVDAAqKQAGVLGARMTGAGFGGCAIALVKEE 353
Cdd:PTZ00298 229 EAKEALQKGNLFRVGELMN-ANHDLCQKLTVSCRELDSIVQTC-RTYGALGAKMSGTGRGGLVVALAASE 296
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 115-183 1.24e-03

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 36.76  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488220203  115 ELLVEGTIPNGAGlsssaslellVG----------VVLEDLFDlktdrLELVQTGKKVENEFIGVNSGIMDQFAIGFGE 183
Cdd:pfam00288   1 DIEIESNIPLGAG----------LGssaalavallLALNELFG-----LPLAKLALEAEELAGGGRGGGMDVAASLYGG 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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