|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
21-367 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 511.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 21 MDAFFASVEERDHPEFRGHPLVIARHPsdtGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYSDISKQ 100
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSP---GRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 101 VREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKPRGITVVA 180
Cdd:PRK02406 78 IREIFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVIT 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 181 PQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPVNVTRERKSVGK 260
Cdd:PRK02406 158 PEEVDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 261 EHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQ--KHGKTVVLKVRYTDYSTVTKRVTLPEyiYKKEALFYQASLIWEEI 338
Cdd:PRK02406 238 ERTFAEDLYDLEACLAELPRLAEKLERRLERAKpdKRIKTVGVKLKFADFQQTTKEHTADP--LDKADLIELLAQALLRR 315
|
330 340
....*....|....*....|....*....
gi 488222827 339 LGvEKGIRLLGITLTNLDPMTYENIVLPL 367
Cdd:PRK02406 316 LG-GRGVRLLGVGVTLLEPQLERQLLLDL 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
17-355 |
3.39e-175 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 490.50 E-value: 3.39e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 17 IHIDMDAFFASVEERDHPEFRGHPLVIARHPsdtgGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYSD 96
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSS----DRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYRE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 97 ISKQVREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKPRGI 176
Cdd:cd03586 77 VSRQIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 177 TVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPVNVTRERK 256
Cdd:cd03586 157 TVIPPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 257 SVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFYQASLIWE 336
Cdd:cd03586 237 SIGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLE 316
|
330
....*....|....*....
gi 488222827 337 EILGvEKGIRLLGITLTNL 355
Cdd:cd03586 317 ELLD-GRPIRLLGVRLSGL 334
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
14-353 |
8.60e-162 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 456.53 E-value: 8.60e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 14 RKIIHIDMDAFFASVEERDHPEFRGHPLVIArhpsDTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHK 93
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVG----GDNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFEL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 94 YSDISKQVREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKP 173
Cdd:COG0389 77 YRDVSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 174 RGITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPVNVTR 253
Cdd:COG0389 157 DGLTVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPVEPRR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 254 ERKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFYQASL 333
Cdd:COG0389 237 PRKSIGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARE 316
|
330 340
....*....|....*....|
gi 488222827 334 IWEEILGVEKGIRLLGITLT 353
Cdd:COG0389 317 LLERIYRPGRPVRLLGVRLS 336
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
12-365 |
4.47e-119 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 348.63 E-value: 4.47e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 12 TSRKIIHIDMDAFFASVEERDHPEFRGHPLVIArhpsDTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDH 91
Cdd:PRK14133 1 MDRVIIHVDMDAFFASVEQMDNPKLKGKPVIVG----GISERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRH 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 92 HKYSDISKQVREVFYRYTDIVEPVSIDEAYLDVTENKincKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQ 171
Cdd:PRK14133 77 ERYKEVSKNIFKILYEVTPIVEPVSIDEAYLDITNIK---EEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWN 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 172 KPRGITVVApQDAVP-FLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPVN 250
Cdd:PRK14133 154 KPDGIKIIT-EDMIPdILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVE 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 251 VTRERKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFYQ 330
Cdd:PRK14133 233 VSRERKSIGKETTLKKDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNV 312
|
330 340 350
....*....|....*....|....*....|....*
gi 488222827 331 ASLIWEEIlGVEKGIRLLGITLTNLDPMTYENIVL 365
Cdd:PRK14133 313 ACEILEHI-NIKEPIRLIGLSVSNLSENKIEQLSF 346
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
13-355 |
4.74e-101 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 304.65 E-value: 4.74e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 13 SRKIIHIDMDAFFASVEERDHPEFRGHPLVIARHPSDTggRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHH 92
Cdd:PRK01810 4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGNEKER--KGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 93 KYSDISKQVREVFYRYTDIVEPVSIDEAYLDVTEnKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQK 172
Cdd:PRK01810 82 RYREASRQMFQILSEFTPLVQPVSIDEGYLDITD-CYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 173 PRGITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPVNVT 252
Cdd:PRK01810 161 PLGITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRPVDPE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 253 R--ERKSVGKEHTYGQPLqTEEAVLTQ-LRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFY 329
Cdd:PRK01810 241 AiyQFKSVGNSTTLSHDM-DEEKELLDvLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKNPIWEKRDIFQ 319
|
330 340
....*....|....*....|....*.
gi 488222827 330 QASLIWEEILGvEKGIRLLGITLTNL 355
Cdd:PRK01810 320 AASRLFKQHWN-GDPVRLLGVTATDL 344
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
16-357 |
2.80e-92 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 282.59 E-value: 2.80e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 16 IIHIDMDAFFASVEERDHPEFRGHPLVIArhpsdTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYS 95
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIG-----GGKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 96 DISKQVREVFYRYTDIVEPVSIDEAYLDV--TENKINCKSAIKIARmIQADIWESVQLTCSAGVSYNKFLAKLASDYQKP 173
Cdd:PRK02794 113 RVGREVRAMMQALTPLVEPLSIDEAFLDLsgTERLHGAPPAVVLAR-FARRVEREIGITVSVGLSYNKFLAKIASDLDKP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 174 RGITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPVNVTR 253
Cdd:PRK02794 192 RGFSVIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 254 ERKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFYQA-S 332
Cdd:PRK02794 272 EAKSVSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTArE 351
|
330 340
....*....|....*....|....*
gi 488222827 333 LIWEEILGveKGIRLLGITLTNLDP 357
Cdd:PRK02794 352 LLEKETDG--TAFRLIGIGVSDLSP 374
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
16-367 |
2.91e-88 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 271.47 E-value: 2.91e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 16 IIHIDMDAFFASVEERDHPEFRGHPLVIarhpsdtgGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYS 95
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIV--------GGGVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 96 DISKQVREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKPRG 175
Cdd:PRK03858 78 RASKAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 176 ITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGK-MGYSLYRKVRGIHDSPVNVTRE 254
Cdd:PRK03858 158 LLVVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPaAGRHLHALAHNRDPRRVETGRR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 255 RKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFYQA-SL 333
Cdd:PRK03858 238 RRSVGAQRALGRGPNSPAEVDAVVVALVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAArDL 317
|
330 340 350
....*....|....*....|....*....|....*
gi 488222827 334 IWEEI-LGVEKGIRLLGITLTNLDPMTYENIVLPL 367
Cdd:PRK03858 318 VAAAApLIAERGLTLVGFAVSNLDDDGAQQLELPF 352
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
12-355 |
1.43e-84 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 264.10 E-value: 1.43e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 12 TSRKIIHIDMDAFFASVEERDHPEFRGHPLVIArhpsDTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQ-AIFKPGD 90
Cdd:PRK03348 3 AQRWVLHLDMDAFFASVEQLTRPTLRGRPVLVG----GLGGRGVVAGASYEARVFGARSAMPMHQARRLVGNgAVVLPPR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 91 HHKYSDISKQVREVFYRYTDIVEPVSIDEAYLDVTE-NKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASD 169
Cdd:PRK03348 79 FVVYRAASRRVFDTLRELSPVVEQLSFDEAFVEPAElAGASAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 170 YQKPRGITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGK-MGYSLYRKVRGIHDSP 248
Cdd:PRK03348 159 LAKPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGAtVGPALHRLARGIDDRP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 249 VNVTRERKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALF 328
Cdd:PRK03348 239 VAERAEAKQISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVLA 318
|
330 340
....*....|....*....|....*....
gi 488222827 329 YQAS--LIWEEILGvekGIRLLGITLTNL 355
Cdd:PRK03348 319 ATARrlLLDPDEIG---PIRLVGVGFSGL 344
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
14-372 |
9.81e-68 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 219.10 E-value: 9.81e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 14 RKIIHIDMDAFFASVEERDHPEFRGHPLVIARHPSDTggRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHK 93
Cdd:PRK03103 3 RVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERR--SGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 94 YSDISKQVREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASD---Y 170
Cdd:PRK03103 81 YIDVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDnfaK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 171 QKPRGITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPVN 250
Cdd:PRK03103 161 KNPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGINGEVLWRTANGIDYSPVT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 251 VTR--ERKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVT---KRVTLPEY----- 320
Cdd:PRK03103 241 PHSldRQKAIGHQMTLPRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsRQMTLPEPtnlam 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 488222827 321 -IYKKEA-LFYQAsliWEeilgvEKGIRLLGITLTNLDPMTYENivLPLWENQE 372
Cdd:PRK03103 321 eVYEAACkLFHRH---WD-----GKPVRRVGVTLSNLVSDDVWQ--LSLFGDRE 364
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
14-352 |
9.95e-68 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 217.20 E-value: 9.95e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 14 RKIIHIDMDAFFASVEERDHPEFRGHPLVIARHPSDTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHK 93
Cdd:PRK03352 5 RWVLHVDLDQFIAAVELLRRPELAGLPVIVGGNGDPTEPRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 94 YSDISKQVREVFYRYTDIVEPVSIDEAYLDVTENkinckSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKP 173
Cdd:PRK03352 85 YDAASEEVMATLRDLGVPVEVWGWDEAFLGVDTD-----DPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 174 RGITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFG-KMGYSLYRKVRGIHDSPVNVT 252
Cdd:PRK03352 160 AGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEVSAE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 253 -RERKSVGKEHTYGQPL----QTEEAVLTQLRQLAEKVEEALRRVQKhgktVVLKVRYTDYSTVTKRVTLPEYIYKKEAL 327
Cdd:PRK03352 240 pWVPRSRSREVTFPQDLtdraEVESAVRELARRVLDEVVAEGRPVTR----VAVKVRTATFYTRTKIRKLPEPTTDPDVI 315
|
330 340
....*....|....*....|....*
gi 488222827 328 FYQASLIWEEIlGVEKGIRLLGITL 352
Cdd:PRK03352 316 EAAALDVLDRF-ELDRPVRLLGVRL 339
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
18-353 |
1.56e-67 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 216.46 E-value: 1.56e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 18 HIDMDAFFASVEERDHPEFRGHPLVIARHpsdTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYSDI 97
Cdd:cd00424 2 HIDFDNFFASVEQLARPELKGRPVVVVPF---NSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 98 SKQVREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESV-QLTCSAGVSYNKFLAKLASDYQKPRGI 176
Cdd:cd00424 79 SERLLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 177 TVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYEC-TEMMLIRNFGKMGYSLYRKVRGIHDSPVNVTRER 255
Cdd:cd00424 159 TILDPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAAsPDALLALWGGVSGERLWYALRGIDDEPLSPPRPR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 256 KSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTK-----RVTLPEYIYKKEALFYQ 330
Cdd:cd00424 239 KSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRWSGHadipsRSAPRPISTEDGELLHA 318
|
330 340
....*....|....*....|....*
gi 488222827 331 ASLIWEEILGVEKG--IRLLGITLT 353
Cdd:cd00424 319 LDKLWRALLDDKGPrrLRRLGVRLS 343
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
7-303 |
2.51e-66 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 215.26 E-value: 2.51e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 7 PLHNDTSRKIIHIDMDAFFASVEERDHPEFRGHPLVIArhpSDTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIF 86
Cdd:cd01701 40 SIHPDLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVC---HGKGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQLVT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 87 KPGDHHKYSDISKQVREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKI-ARMIQADIWESVQLTCSAGVSYNKFLAK 165
Cdd:cd01701 117 LPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETYELPEElAEAIRNEIRETTGCSASVGIGPNILLAR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 166 LASDYQKPRGITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYT--GKDLYECTEMMLIRNFG-KMGYSLYRKVR 242
Cdd:cd01701 197 LATRKAKPDGQYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTcgGLELRSKTKEKLQKVLGpKTGEKLYDYCR 276
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488222827 243 GIHDSPVNVTRERKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKV 303
Cdd:cd01701 277 GIDDRPVTGEKERKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITLKL 337
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
19-169 |
4.05e-61 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 193.17 E-value: 4.05e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 19 IDMDAFFASVEERDHPEFRGHPLVIARHPsdtgGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYSDIS 98
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGN----GRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRAS 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488222827 99 KQVREVFYRY-TDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASD 169
Cdd:pfam00817 77 RKIFEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
18-354 |
4.76e-54 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 182.13 E-value: 4.76e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 18 HIDMDAFFASVEERDHPEFRGHPLVIARHPSdtggrgvVTTANYEARKFGIHSAMSAQKAYELCPQ------AIFKPG-- 89
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAVVQWNS-------IIAVSYAARAFGVTRFMTIDEAKKKCPDlilahvATYKKGed 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 90 ----------DHHK-----YSDISKQVREVFYRYTDIVEPVSIDEAYLDVtenkincksAIKIARMIQADIWESVQLTCS 154
Cdd:cd01702 75 eadyhenpspARHKvsldpYRRASRKILNILKRFGDVVEKASIDEAYLDL---------GSRIVEEIRQQVYDELGYTCS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 155 AGVSYNKFLAKLASDYQKPRGITVVaPQDAVP-FLKALPIEKFHGVGKKtvpRMHELGIYTGKDlYEC-------TEMML 226
Cdd:cd01702 146 AGIAHNKMLAKLASGMNKPNAQTIL-RNDAVAsFLSSLPITSIRGLGGK---LGEEIIDLLGLP-TEGdvagfrsSESDL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 227 IRNFG-KMGYSLYRKVRGIHDSPVNVTRERKSVGKEHTYGQP--LQTEEAV--LTQLRQ-LAEKVEEALRRVQKHGKTVV 300
Cdd:cd01702 221 QEHFGeKLGEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFPGKtaLSTEDVQhwLLVLASeLNSRLEDDRYENNRRPKTLV 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 488222827 301 LKVR-YTDYSTVTKRVTLPEYIYKK--EALFYQASLIWEEILGVEK--GIRLLGITLTN 354
Cdd:cd01702 301 LSLRqRGDGVRRSRSCALPRYDAQKivKDAFKLIKAINEEGLGLAWnyPLTLLSLSFTK 359
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
19-305 |
7.98e-54 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 180.82 E-value: 7.98e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 19 IDMDAFFASVEERDHPEFRGHPLVIArhpSDTGGRgvVTTANYEARKFGIHSAMSAQKAYELCPQ---AIFKPgDHHKYS 95
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVVL---SNNDGC--VIARSPEAKALGIKMGSPYFKVPDLLERhgvAVFSS-NYALYG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 96 DISKQVREVFYRYTDIVEPVSIDEAYLDVTeNKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDY--QKP 173
Cdd:cd01700 77 DMSRRIMSILERFSPDVEVYSIDESFLDLT-GSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLakKKN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 174 RGITVVA---PQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECTEMMLIRNFGKMGYSLYRKVRGIHDSPV- 249
Cdd:cd01700 156 PYGGVVDltdEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLe 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 488222827 250 NVTRERKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRY 305
Cdd:cd01700 236 EYPPPKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGT 291
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
16-355 |
4.10e-53 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 179.60 E-value: 4.10e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 16 IIHIDMDAFFASVEERDHPEFRGHPLVIARHPSDTGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYS 95
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 96 DISKQVREVFYRYTDIVEPVSIDEAYLDVTENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKPRG 175
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 176 ITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDL--YECTEMMLIRNFGKMGYsLYRKVRGIHDSPVNvTR 253
Cdd:PRK01216 163 IKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTlrIEFDELKGIIGEAKAKY-LFSLARNEYNEPVR-AR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 254 ERKSVGKEHTYGQPLQTEEAVLTQLRQlaeKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFYQASL 333
Cdd:PRK01216 241 VRKSIGRYVTLPRNTRDLEEIKPYLKR---AIEEAYYKLDGIPKAIHVVAIMEDLDIVSRGRTFTHGISKETAYREAVRL 317
|
330 340
....*....|....*....|..
gi 488222827 334 IWEEILGVEKGIRLLGITLTNL 355
Cdd:PRK01216 318 LQKILEEDERKIRRIGVRFSKI 339
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
17-354 |
5.79e-45 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 158.79 E-value: 5.79e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 17 IHIDMDAFFASVEERDHPEFRGHPLVIARhpsdtggRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPG-DHHKYS 95
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQ-------KYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGeDLTPFR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 96 DISKQVREVFYRYT--DIVEPVSIDEAYLDVTENKINCKSaiKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKP 173
Cdd:cd01703 74 DMSKKVYRLLRSYSwnDRVERLGFDENFMDVTEMRLLVAS--HIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 174 RGITVVAP---QDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYECT--------------EMMLIR-NFGKM-G 234
Cdd:cd01703 152 NQQTTLLPpscADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSnrnrqtvgaapsllELLLMVkEFGEGiG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 235 YSLYRKVRGIHDSPVNVTRER-KSVGKEHTYGQP-LQTEEAVLTQLRQ----LAEKVEEALRRVQK----HGKTVVLKVR 304
Cdd:cd01703 232 QRIWKLLFGRDTSPVKPASDFpQQISIEDSYKKCsLEEIREARNKIEEllasLLERMKQDLQEVKAgdgrRPHTLRLTLR 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488222827 305 -YTD----YSTVTKRVTLPEYIYKK-EALFYQASLIWEEIL------------GVEKGIRLLGITLTN 354
Cdd:cd01703 312 rYTStkkhYNRESKQAPIPSHVFQKlTGGNEIAARPIEKILmrlfrelvppknVKGFNLTLLNVCFTN 379
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
17-320 |
1.98e-31 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 125.13 E-value: 1.98e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 17 IHIDMDAFFASVEERDHPEFRGHPLVIarhpsdtGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYSD 96
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAI-------GTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNE 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 97 ISKQVREVFYRYTDIVEPVSIDEAYLDVT---ENKINCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLASDYQKP 173
Cdd:PTZ00205 209 ESNTVRRIVAEYDPNYISFGLDELTLEVSayiERFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKP 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 174 RG---ITVVAPQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYE-----CT-------EMMLIRNFGKMGYSLY 238
Cdd:PTZ00205 289 NGqhdLNLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNrrvelCYilhnnlfRFLLGASIGIMQWPDA 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 239 RKVRGIHDSPVNVTRERKSVGKEHTYgQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLP 318
Cdd:PTZ00205 369 ATAANTENCEGATGGQRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQQYTKSLI 447
|
..
gi 488222827 319 EY 320
Cdd:PTZ00205 448 QY 449
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
255-357 |
8.89e-26 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 99.56 E-value: 8.89e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 255 RKSVGKEHTYGQPLQTEEAVLTQLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPEYIYKKEALFYQASLI 334
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80
|
90 100
....*....|....*....|...
gi 488222827 335 WEEILGvEKGIRLLGITLTNLDP 357
Cdd:pfam11799 81 LRRLYR-GRPVRLLGVSLSNLVP 102
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
31-319 |
1.08e-18 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 85.90 E-value: 1.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 31 RDHPEFRGHPLVIARHpsdtGGRGVVTTANYEARKFGIHSAMSAQKAYELCPQAIFKPGDHHKYSDISKQVREVFYRYTD 110
Cdd:cd03468 15 RNRPADDEAPLAVVER----KKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 111 IVEPVSIDEAYLDVT-ENKINCKSAIKIARMIQADiwESVQLTCSAGVSYNKFLAKLASDYQKPRGIT-VVAPQDAVPFL 188
Cdd:cd03468 91 LVALDGPDGLLLDVTgCLHLFGGEDALAASLRAAL--ATLGLSARAGIADTPGAAWLLARAGGGRGVLrREALAAALVLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 189 KALPIEkFHGVGKKTVPRMHELGIYTGKDL---YECTemmLIRNFGKMGYSLYRKVRGIHDSPVNVT--RERKSVGKEHT 263
Cdd:cd03468 169 APLPVA-ALRLPPETVELLARLGLRTLGDLaalPRAE---LARRFGLALLLRLDQAYGRDPEPLLFSppPPAFDFRLELQ 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 488222827 264 YGQPLQTEEAVLtqLRQLAEKVEEALRRVQKHGKTVVLKVRYTDYSTVTKRVTLPE 319
Cdd:cd03468 245 LEEPIARGLLFP--LRRLLEQLCAFLALRGLGARRLSLTLFREDGRVTRVLVGLAR 298
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
18-290 |
4.66e-18 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 84.82 E-value: 4.66e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 18 HIDMDAFFASVEERDHPEFRGHPLVIArhpsdTGGRGVVTTANYEARKFGIhsAMSA----QKAYELCPQAIFKPGDHHK 93
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVVL-----SNNDGCVIARSAEAKALGI--KMGDpwfkQKDLFRRCGVVCFSSNYEL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 94 YSDISKQVREVFYRYTDIVEPVSIDEAYLDVTENKiNCKSAIKIARMIQADIWESVQLTCSAGVSYNKFLAKLAS----D 169
Cdd:PRK03609 77 YADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVR-NCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANhaakK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488222827 170 YQKPRGiTVVA---PQDAVPFLKALPIEKFHGVGKKTVPRMHELGIYTGKDLYEcTEMMLIR-NFGKMgysLYRKVRGIH 245
Cdd:PRK03609 156 WQRQTG-GVVDlsnLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLAD-TNIRFIRkHFNVV---LERTVRELR 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 488222827 246 DSPVNVTRERKSVGKE----HTYGQPLQTEEAVLTQLRQLAEKVEEALR 290
Cdd:PRK03609 231 GEPCLSLEEFAPTKQEivcsRSFGERITDYESMRQAICSYAARAAEKLR 279
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
181-212 |
1.26e-05 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 41.61 E-value: 1.26e-05
10 20 30
....*....|....*....|....*....|..
gi 488222827 181 PQDAVPFLKALPIEKFHGVGKKTVPRMHELGI 212
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| |
