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Conserved domains on  [gi|488225579|ref|WP_002296787|]
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MULTISPECIES: IS3 family transposase, partial [Enterococcus]

Protein Classification

transposase( domain architecture ID 11459289)

transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism; similar to Escherichia coli IS150 protein InsAB

CATH:  1.10.10.10
Gene Ontology:  GO:0006313|GO:0003677|GO:0004803
PubMed:  20885819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
57-150 4.48e-13

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


:

Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 61.09  E-value: 4.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488225579  57 KSYTTKFKLDVIEYMETNGLSIQETAKKFNIGSNrTLSKWIEQYEEGGASSLESQKRgrkismnsklNIPKKLKDESLEE 136
Cdd:COG2963    6 RRYSPEFKAEAVRLVLEGGASVAEVARELGISPS-TLYRWVRQYREGGLGGFPGDGR----------TTPEQAEIRRLRK 74

                         90
                 ....*....|....
gi 488225579 137 EVIRLRAENAYLKK 150
Cdd:COG2963   75 ELRRLEMENDILKK 88
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
1-59 1.52e-06

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


:

Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 43.76  E-value: 1.52e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488225579   1 MRKYTFVFKKKVVSDYLNNEGGYKYLAHKYQINRTLVRHWVRIYNYHGWEGLVGGGKSY 59
Cdd:COG2963    5 RRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTT 63
 
Name Accession Description Interval E-value
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
57-150 4.48e-13

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 61.09  E-value: 4.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488225579  57 KSYTTKFKLDVIEYMETNGLSIQETAKKFNIGSNrTLSKWIEQYEEGGASSLESQKRgrkismnsklNIPKKLKDESLEE 136
Cdd:COG2963    6 RRYSPEFKAEAVRLVLEGGASVAEVARELGISPS-TLYRWVRQYREGGLGGFPGDGR----------TTPEQAEIRRLRK 74

                         90
                 ....*....|....
gi 488225579 137 EVIRLRAENAYLKK 150
Cdd:COG2963   75 ELRRLEMENDILKK 88
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 63-116 4.38e-09

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 49.51  E-value: 4.38e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488225579   63 FKLDVIEYMeTNGLSIQETAKKFNIgSNRTLSKWIEQYEEGGASSLESQKRGRK 116
Cdd:pfam13518   1 ERLKIVLLA-LEGESIKEAARLFGI-SRSTVYRWIRRYREGGLEGLLPRRRRPK 52
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
1-59 1.52e-06

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 43.76  E-value: 1.52e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488225579   1 MRKYTFVFKKKVVSDYLNNEGGYKYLAHKYQINRTLVRHWVRIYNYHGWEGLVGGGKSY 59
Cdd:COG2963    5 RRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTT 63
transpos_IS630 NF033545
IS630 family transposase;
75-144 1.42e-05

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 43.40  E-value: 1.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488225579  75 GLSIQETAKKFNIgSNRTLSKWIEQYEEGGASSLESQKR-GRkismnsklniPKKLKDESLEEEVIRLRAE 144
Cdd:NF033545  12 GLSITEIAERLGV-SRSTVYRWLKRFNEGGLEGLLDKPRpGR----------PRKLLSEQQAELLALLLEE 71
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 8-53 1.80e-05

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 39.88  E-value: 1.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 488225579    8 FKKKVVSDYLNNEGgYKYLAHKYQINRTLVRHWVRIYNYHGWEGLV 53
Cdd:pfam13518   1 ERLKIVLLALEGES-IKEAARLFGISRSTVYRWIRRYREGGLEGLL 45
 
Name Accession Description Interval E-value
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
57-150 4.48e-13

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 61.09  E-value: 4.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488225579  57 KSYTTKFKLDVIEYMETNGLSIQETAKKFNIGSNrTLSKWIEQYEEGGASSLESQKRgrkismnsklNIPKKLKDESLEE 136
Cdd:COG2963    6 RRYSPEFKAEAVRLVLEGGASVAEVARELGISPS-TLYRWVRQYREGGLGGFPGDGR----------TTPEQAEIRRLRK 74

                         90
                 ....*....|....
gi 488225579 137 EVIRLRAENAYLKK 150
Cdd:COG2963   75 ELRRLEMENDILKK 88
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 63-116 4.38e-09

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 49.51  E-value: 4.38e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488225579   63 FKLDVIEYMeTNGLSIQETAKKFNIgSNRTLSKWIEQYEEGGASSLESQKRGRK 116
Cdd:pfam13518   1 ERLKIVLLA-LEGESIKEAARLFGI-SRSTVYRWIRRYREGGLEGLLPRRRRPK 52
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 75-144 2.79e-07

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 48.31  E-value: 2.79e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488225579  75 GLSIQETAKKFNIgSNRTLSKWIEQYEEGGASSLESQKRGRKismnsklniPKKLKDEsLEEEVIRLRAE 144
Cdd:COG3415   38 GLSVREIAERLGV-SRSTVYRWLKRYREGGLAGLKDRPRGGR---------PSKLSDE-QRERLLELLRE 96
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
1-59 1.52e-06

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 43.76  E-value: 1.52e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488225579   1 MRKYTFVFKKKVVSDYLNNEGGYKYLAHKYQINRTLVRHWVRIYNYHGWEGLVGGGKSY 59
Cdd:COG2963    5 RRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTT 63
transpos_IS630 NF033545
IS630 family transposase;
75-144 1.42e-05

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 43.40  E-value: 1.42e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488225579  75 GLSIQETAKKFNIgSNRTLSKWIEQYEEGGASSLESQKR-GRkismnsklniPKKLKDESLEEEVIRLRAE 144
Cdd:NF033545  12 GLSITEIAERLGV-SRSTVYRWLKRFNEGGLEGLLDKPRpGR----------PRKLLSEQQAELLALLLEE 71
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 8-53 1.80e-05

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 39.88  E-value: 1.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 488225579    8 FKKKVVSDYLNNEGgYKYLAHKYQINRTLVRHWVRIYNYHGWEGLV 53
Cdd:pfam13518   1 ERLKIVLLALEGES-IKEAARLFGISRSTVYRWIRRYREGGLEGLL 45
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 57-146 1.06e-04

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 38.49  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488225579   57 KSYTTKFKLDVIEYMETNGLSIQETAKKFNIGSNrTLSKWIEQYEEGGASSlesqkrgrkismnsklNIPKKLKDesLEE 136
Cdd:pfam01527   5 RRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPN-TLYQWRRQYEGGMGAS----------------PARPRLTA--LEE 65

                          90
                  ....*....|
gi 488225579  137 EVIRLRAENA 146
Cdd:pfam01527  66 ENRRLKRELA 75
HTH_32 pfam13565
Homeodomain-like domain;
92-145 4.15e-04

Homeodomain-like domain;


Pssm-ID: 463923 [Multi-domain]  Cd Length: 73  Bit Score: 36.89  E-value: 4.15e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488225579   92 TLSKWIEQYEEGGASSLESQKRGRKismnsklniPKKLKDEsLEEEVIRLRAEN 145
Cdd:pfam13565   1 TVYRWRKRYNEEGLEGLEDRPRRGR---------PRKLTDE-QEARLLALLCEE 44
HTH_23 pfam13384
Homeodomain-like domain;
74-108 9.84e-04

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 35.32  E-value: 9.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 488225579   74 NGLSIQETAKKFNIgSNRTLSKWIEQYEEGGASSL 108
Cdd:pfam13384  16 EGLSVKEIAELLGV-SRRTVYRWLKRYNEEGLEGL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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