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Conserved domains on  [gi|488233921|ref|WP_002305129|]
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MULTISPECIES: type II toxin-antitoxin system HicB family antitoxin [Enterococcus]

Protein Classification

type II toxin-antitoxin system HicB family antitoxin( domain architecture ID 581201)

type II toxin-antitoxin system HicB family antitoxin is the antitoxin component of a type II toxin-antitoxin (TA) system and functions as an mRNA interferase antitoxin preventing effects of the cognate HicA family toxin

Gene Ontology:  GO:0110001
PubMed:  30337369|16895922|28279904
SCOP:  4001747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HicB_lk_antitox super family cl23837
HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like ...
 5-104 2.71e-19

HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like antitoxins.


The actual alignment was detected with superfamily member pfam15919:

Pssm-ID: 451570 [Multi-domain]  Cd Length: 123  Bit Score: 76.92  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488233921    5 YPVIFSAEEN-GYSVVFPDFAGA-TQGDNFEEAMSNAKEFLDGILAYYIDEDISVPSPTDIHQLNNLGNNK--IVSLIQS 80
Cdd:pfam15919   1 YPIAIEKDEDsAYGVVVPDLPGCfSAGDTLEEAIANAEEAIELHIEGLIEDGEAIPAPSSIEELQANPEYAgwIWALVDI 80

                          90       100
                  ....*....|....*....|....
gi 488233921   81 DPSPfIQKKTVRKNVTVPEWLVAR 104
Cdd:pfam15919  81 DLSP-LDGKSERINITLPRRVLRR 103
 
Name Accession Description Interval E-value
HicB_lk_antitox pfam15919
HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like ...
 5-104 2.71e-19

HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like antitoxins.


Pssm-ID: 435020 [Multi-domain]  Cd Length: 123  Bit Score: 76.92  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488233921    5 YPVIFSAEEN-GYSVVFPDFAGA-TQGDNFEEAMSNAKEFLDGILAYYIDEDISVPSPTDIHQLNNLGNNK--IVSLIQS 80
Cdd:pfam15919   1 YPIAIEKDEDsAYGVVVPDLPGCfSAGDTLEEAIANAEEAIELHIEGLIEDGEAIPAPSSIEELQANPEYAgwIWALVDI 80

                          90       100
                  ....*....|....*....|....
gi 488233921   81 DPSPfIQKKTVRKNVTVPEWLVAR 104
Cdd:pfam15919  81 DLSP-LDGKSERINITLPRRVLRR 103
HicB COG1598
Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];
5-66 6.05e-16

Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441206  Cd Length: 65  Bit Score: 66.83  E-value: 6.05e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488233921   5 YPVIF-SAEENGYSVVFPDFAG-ATQGDNFEEAMSNAKEFLDGILAYYIDEDISVPSPTDIHQL 66
Cdd:COG1598    2 YPAIIeKDEDGGYVAEVPDLPGcVTQGDTLEEALENAKEALELHLEALLEDGEPIPEPSSIEET 65
 
Name Accession Description Interval E-value
HicB_lk_antitox pfam15919
HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like ...
 5-104 2.71e-19

HicB_like antitoxin of bacterial toxin-antitoxin system; This is a family of HicB-like antitoxins.


Pssm-ID: 435020 [Multi-domain]  Cd Length: 123  Bit Score: 76.92  E-value: 2.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488233921    5 YPVIFSAEEN-GYSVVFPDFAGA-TQGDNFEEAMSNAKEFLDGILAYYIDEDISVPSPTDIHQLNNLGNNK--IVSLIQS 80
Cdd:pfam15919   1 YPIAIEKDEDsAYGVVVPDLPGCfSAGDTLEEAIANAEEAIELHIEGLIEDGEAIPAPSSIEELQANPEYAgwIWALVDI 80

                          90       100
                  ....*....|....*....|....
gi 488233921   81 DPSPfIQKKTVRKNVTVPEWLVAR 104
Cdd:pfam15919  81 DLSP-LDGKSERINITLPRRVLRR 103
HicB COG1598
Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];
5-66 6.05e-16

Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441206  Cd Length: 65  Bit Score: 66.83  E-value: 6.05e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488233921   5 YPVIF-SAEENGYSVVFPDFAG-ATQGDNFEEAMSNAKEFLDGILAYYIDEDISVPSPTDIHQL 66
Cdd:COG1598    2 YPAIIeKDEDGGYVAEVPDLPGcVTQGDTLEEALENAKEALELHLEALLEDGEPIPEPSSIEET 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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