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Conserved domains on  [gi|488251554|ref|WP_002322762|]
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MULTISPECIES: type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein [Enterococcus]

Protein Classification

type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein( domain architecture ID 11475017)

type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein is part of the innate immunity bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection;

PubMed:  24465005|29518409

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 15-197 9.64e-32

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


:

Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 113.94  E-value: 9.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488251554  15 GTLALKDAKK----AGISPVTIKRMVDRGELDREYPGFFTLPGQF----PDELFMAQKKYERGIISHITALDLYDLTDMI 86
Cdd:COG5340    7 GVFTTADARAaglsAGISRRLLSRLVKKGELERVRRGLYVLPPAEadkeHDELLIAARLVPPGYISLLSALALHGLTDQI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488251554  87 PRQIDLTVPYGYHVSEKGlkEFAVELHYTKAEWYELGKIEIKSRyGNPIIAYDPERTLCD-IWNPWYTVEDEIKVKAIKN 165
Cdd:COG5340   87 PFTVYVAVPRRSRPIKIG--GPPIRFVRFSKELFFEGVEEVKID-GGKVRVTSPERTIVDcLRYRNKIGGIDEVLEALRE 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488251554 166 YMELDRKNLRKLNEYRRILP---TDKTMRSYIKAL 197
Cdd:COG5340  164 YLRRKKLDLDKLLEYAERLRnsaVEKRLGYLLEAL 198
 
Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 15-197 9.64e-32

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 113.94  E-value: 9.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488251554  15 GTLALKDAKK----AGISPVTIKRMVDRGELDREYPGFFTLPGQF----PDELFMAQKKYERGIISHITALDLYDLTDMI 86
Cdd:COG5340    7 GVFTTADARAaglsAGISRRLLSRLVKKGELERVRRGLYVLPPAEadkeHDELLIAARLVPPGYISLLSALALHGLTDQI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488251554  87 PRQIDLTVPYGYHVSEKGlkEFAVELHYTKAEWYELGKIEIKSRyGNPIIAYDPERTLCD-IWNPWYTVEDEIKVKAIKN 165
Cdd:COG5340   87 PFTVYVAVPRRSRPIKIG--GPPIRFVRFSKELFFEGVEEVKID-GGKVRVTSPERTIVDcLRYRNKIGGIDEVLEALRE 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488251554 166 YMELDRKNLRKLNEYRRILP---TDKTMRSYIKAL 197
Cdd:COG5340  164 YLRRKKLDLDKLLEYAERLRnsaVEKRLGYLLEAL 198
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 9-52 7.89e-06

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 463849  Cd Length: 49  Bit Score: 41.76  E-value: 7.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 488251554    9 LLEEFNGTLALKDAKKAGISPVTIKRMVDRGELDREYPGFFTLP 52
Cdd:pfam13338   6 LAARQKGIFTTADLAAAGISRRALRRLVRKGLLERLRRGVYALP 49
 
Name Accession Description Interval E-value
AbiEi COG5340
Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system ...
 15-197 9.64e-32

Abortive phage infection protein AbiEi, antitoxin conponent of an AbiEi-AbiEii TA system [Defense mechanisms];


Pssm-ID: 444124 [Multi-domain]  Cd Length: 203  Bit Score: 113.94  E-value: 9.64e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488251554  15 GTLALKDAKK----AGISPVTIKRMVDRGELDREYPGFFTLPGQF----PDELFMAQKKYERGIISHITALDLYDLTDMI 86
Cdd:COG5340    7 GVFTTADARAaglsAGISRRLLSRLVKKGELERVRRGLYVLPPAEadkeHDELLIAARLVPPGYISLLSALALHGLTDQI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488251554  87 PRQIDLTVPYGYHVSEKGlkEFAVELHYTKAEWYELGKIEIKSRyGNPIIAYDPERTLCD-IWNPWYTVEDEIKVKAIKN 165
Cdd:COG5340   87 PFTVYVAVPRRSRPIKIG--GPPIRFVRFSKELFFEGVEEVKID-GGKVRVTSPERTIVDcLRYRNKIGGIDEVLEALRE 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488251554 166 YMELDRKNLRKLNEYRRILP---TDKTMRSYIKAL 197
Cdd:COG5340  164 YLRRKKLDLDKLLEYAERLRnsaVEKRLGYLLEAL 198
AbiEi_4 pfam13338
Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV ...
 9-52 7.89e-06

Transcriptional regulator, AbiEi antitoxin; AbiEi_4 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.


Pssm-ID: 463849  Cd Length: 49  Bit Score: 41.76  E-value: 7.89e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 488251554    9 LLEEFNGTLALKDAKKAGISPVTIKRMVDRGELDREYPGFFTLP 52
Cdd:pfam13338   6 LAARQKGIFTTADLAAAGISRRALRRLVRKGLLERLRRGVYALP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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