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Conserved domains on  [gi|488253687|ref|WP_002324895|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Enterococcus]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
8-102 1.40e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.16  E-value: 1.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488253687   8 KTELESLSDFLAALGDRKRQLILIRLLNEKSChglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHE 87
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELC----VGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADE 79

                         90
                 ....*....|....*
gi 488253687  88 nkNIYKLRDFLSDVI 102
Cdd:COG0640   80 --ALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
8-102 1.40e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.16  E-value: 1.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488253687   8 KTELESLSDFLAALGDRKRQLILIRLLNEKSChglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHE 87
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELC----VGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADE 79

                         90
                 ....*....|....*
gi 488253687  88 nkNIYKLRDFLSDVI 102
Cdd:COG0640   80 --ALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-87 6.31e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 71.72  E-value: 6.31e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488253687  14 LSDFLAALGDRKRQLILIRLLNEKSChglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHE 87
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELC----VCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADE 70
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-103 4.12e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 62.32  E-value: 4.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488253687  18 LAALGDRKRQLILiRLLNEKSCHglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHEnkniYKLRDF 97
Cdd:cd00090    1 LKALSDPTRLRIL-RLLLEGPLT---VSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA----ERLLAL 72


                 ....*.
gi 488253687  98 LSDVID 103
Cdd:cd00090   73 LESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-102 1.48e-12

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 57.99  E-value: 1.48e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488253687    30 LIRLLNEKSCHglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHEnkniyKLRDFLSDVI 102
Cdd:smart00418   2 ILKLLAEGELC---VCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE-----KVADLLEELL 66
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 20-83 1.71e-09

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 50.10  E-value: 1.71e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488253687  20 ALGDRKRQLILiRLLNEKSchgLQVGELTDDTGLSRPAVSHHLKILKDADLleVREEGTKNF-YY 83
Cdd:NF033789   4 ALSDPTRREIL-ELLKEGD---MTAGEIAEHFDMSKPSISHHLNILKQADL--VTDERKGQFiYY 62
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 16-77 2.66e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 46.76  E-value: 2.66e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488253687   16 DFLAALGDRKRQLILiRLLNEKSchGLQVGELTDDTGLSRPAVSHHLKILKDADLLEVREEG 77
Cdd:pfam12840   2 DVAEALADPTRLRIL-RALVGDE--PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
8-102 1.40e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 79.16  E-value: 1.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488253687   8 KTELESLSDFLAALGDRKRQLILIRLLNEKSChglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHE 87
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELC----VGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADE 79

                         90
                 ....*....|....*
gi 488253687  88 nkNIYKLRDFLSDVI 102
Cdd:COG0640   80 --ALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-87 6.31e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 71.72  E-value: 6.31e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488253687  14 LSDFLAALGDRKRQLILIRLLNEKSChglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHE 87
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELC----VCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADE 70
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-103 4.12e-14

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 62.32  E-value: 4.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488253687  18 LAALGDRKRQLILiRLLNEKSCHglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHEnkniYKLRDF 97
Cdd:cd00090    1 LKALSDPTRLRIL-RLLLEGPLT---VSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDA----ERLLAL 72


                 ....*.
gi 488253687  98 LSDVID 103
Cdd:cd00090   73 LESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-102 1.48e-12

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 57.99  E-value: 1.48e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488253687    30 LIRLLNEKSCHglqVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHEnkniyKLRDFLSDVI 102
Cdd:smart00418   2 ILKLLAEGELC---VCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDE-----KVADLLEELL 66
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
29-87 5.63e-10

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 53.34  E-value: 5.63e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488253687  29 ILIRLLNEKSCHGlqvGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTKNFYYLKHE 87
Cdd:COG3398  102 ILLYLLENPGATN---KELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 20-83 1.71e-09

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 50.10  E-value: 1.71e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488253687  20 ALGDRKRQLILiRLLNEKSchgLQVGELTDDTGLSRPAVSHHLKILKDADLleVREEGTKNF-YY 83
Cdd:NF033789   4 ALSDPTRREIL-ELLKEGD---MTAGEIAEHFDMSKPSISHHLNILKQADL--VTDERKGQFiYY 62
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 16-77 2.66e-08

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 46.76  E-value: 2.66e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488253687   16 DFLAALGDRKRQLILiRLLNEKSchGLQVGELTDDTGLSRPAVSHHLKILKDADLLEVREEG 77
Cdd:pfam12840   2 DVAEALADPTRLRIL-RALVGDE--PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 24-71 4.68e-08

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 45.90  E-value: 4.68e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 488253687   24 RKRQLILIRLLNEKSchgLQVGELTDDTGLSRPAVSHHLKILKDADLL 71
Cdd:pfam01022   1 DPTRLKILKLLAEGE---LCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
9-87 1.46e-07

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 45.72  E-value: 1.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488253687   9 TELESLSDFLAALGDRKRQLILiRLLNEKschGLQVGELTDDTGLSRPAVSHHLKILKDADLLEVREE----GTKNFYYL 84
Cdd:COG4189    4 LDDEESLEVLKALASETRLRIL-RLLAEE---PLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKpgkrGRQKICYL 79


                 ...
gi 488253687  85 KHE 87
Cdd:COG4189   80 RVD 82
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
18-79 1.14e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 42.22  E-value: 1.14e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488253687  18 LAALGDRKRQLILiRLLneKSCHGLQVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGTK 79
Cdd:COG2345    7 LAALADPTRRRIL-ELL--KRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRG 65
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
13-112 2.94e-05

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 41.42  E-value: 2.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488253687  13 SLSDFLAALGDRKRqliLIRLLNEKSChglQVGELTDDTGLSRPAVSHHLKILKDADLLEvREEGT-----------KNF 81
Cdd:COG4742    7 DLLDFLFLSEKRKN---ILLLLAEGPK---TRSELAESLDVSRSTILRQLKELEERGLIE-RDDGEyelttlgrlvvEEM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488253687  82 YYLKHENKNIYKLRDFLSDV---------IDEIEELKNSE 112
Cdd:COG4742   80 EPLLDTLEVLEENRDYWETHdlsaippelLLRIGELGDAT 119
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-78 9.81e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 32.18  E-value: 9.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 488253687   41 GLQVGELTDDTGLSRPAVSHHLKILKDADLLEVREEGT 78
Cdd:pfam12802  19 GLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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