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Conserved domains on  [gi|488256981|ref|WP_002328189|]
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class I SAM-dependent methyltransferase [Enterococcus faecium]

Protein Classification

class I SAM-dependent DNA methyltransferase( domain architecture ID 11471966)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047
PubMed:  23180741|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
2-140 4.12e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 105.47  E-value: 4.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   2 AYETFAFIYDEVMDETL-YQQWLAFSKRHLQE----DTKNILELACGTGALAVAFAKDGYKVTGLDLSEEMLMIASQRAy 76
Cdd:COG4976   10 LFDQYADSYDAALVEDLgYEAPALLAEELLARlppgPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG- 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488256981  77 eedASIQFVEGNMLDLSEI-GQYQAITCfSDSLCYMknrQEVQQVFDEVYQALEENGRFLFDVHS 140
Cdd:COG4976   89 ---VYDRLLVADLADLAEPdGRFDLIVA-ADVLTYL---GDLAAVFAGVARALKPGGLFIFSVED 146
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
2-140 4.12e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 105.47  E-value: 4.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   2 AYETFAFIYDEVMDETL-YQQWLAFSKRHLQE----DTKNILELACGTGALAVAFAKDGYKVTGLDLSEEMLMIASQRAy 76
Cdd:COG4976   10 LFDQYADSYDAALVEDLgYEAPALLAEELLARlppgPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG- 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488256981  77 eedASIQFVEGNMLDLSEI-GQYQAITCfSDSLCYMknrQEVQQVFDEVYQALEENGRFLFDVHS 140
Cdd:COG4976   89 ---VYDRLLVADLADLAEPdGRFDLIVA-ADVLTYL---GDLAAVFAGVARALKPGGLFIFSVED 146
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 37-132 2.44e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 90.32  E-value: 2.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   37 ILELACGTGALAVAFAKD-GYKVTGLDLSEEMLMIASQRAYEEDASIQFVEGNMLDLS-EIGQYQAITCfSDSLCYMkNR 114
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPfPDGSFDLVVS-SGVLHHL-PD 78

                          90
                  ....*....|....*...
gi 488256981  115 QEVQQVFDEVYQALEENG 132
Cdd:pfam13649  79 PDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 36-138 2.95e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 66.68  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  36 NILELACGTGALAVAFAKD-GYKVTGLDLSEEMLMIASQRAYEEDAS-IQFVEGNMLDLS--EIGQYQAITCfsdSLCYM 111
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPpeADESFDVIIS---DPPLH 77

                         90       100
                 ....*....|....*....|....*..
gi 488256981 112 KNRQEVQQVFDEVYQALEENGRFLFDV 138
Cdd:cd02440   78 HLVEDLARFLEEARRLLKPGGVLVLTL 104
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 36-92 2.51e-11

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 61.71  E-value: 2.51e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488256981  36 NILELACGTGALAVAFAKDGYK---VTGLDLSEEMLMIASQRAYEEDAS--IQFVEGNMLDL 92
Cdd:PRK00216  54 KVLDLACGTGDLAIALAKAVGKtgeVVGLDFSEGMLAVGREKLRDLGLSgnVEFVQGDAEAL 115
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 31-102 6.89e-04

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 40.03  E-value: 6.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488256981   31 QEDTKNILELACGTGALAVAFAKD--GYKVTGLDLSEEMLMIASQRAYEEDAS--IQFVEGNMLDLSEIGQYQAIT 102
Cdd:TIGR00536 112 QPPILHILDLGTGSGCIALALAYEfpNAEVIAVDISPDALAVAEENAEKNQLEhrVEFIQSNLFEPLAGQKIDIIV 187
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
2-140 4.12e-28

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 105.47  E-value: 4.12e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   2 AYETFAFIYDEVMDETL-YQQWLAFSKRHLQE----DTKNILELACGTGALAVAFAKDGYKVTGLDLSEEMLMIASQRAy 76
Cdd:COG4976   10 LFDQYADSYDAALVEDLgYEAPALLAEELLARlppgPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG- 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488256981  77 eedASIQFVEGNMLDLSEI-GQYQAITCfSDSLCYMknrQEVQQVFDEVYQALEENGRFLFDVHS 140
Cdd:COG4976   89 ---VYDRLLVADLADLAEPdGRFDLIVA-ADVLTYL---GDLAAVFAGVARALKPGGLFIFSVED 146
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 14-138 1.96e-23

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 91.62  E-value: 1.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  14 MDETLYQQW-----LAFSKRHLQEDtKNILELACGTGALAVAFAKDGYKVTGLDLSEEMLMIASQRAyeEDASIQFVEGN 88
Cdd:COG2227    1 MSDPDARDFwdrrlAALLARLLPAG-GRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERA--AELNVDFVQGD 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488256981  89 MLDLS-EIGQYQAITCFsDSLCYMknrQEVQQVFDEVYQALEENGRFLFDV 138
Cdd:COG2227   78 LEDLPlEDGSFDLVICS-EVLEHL---PDPAALLRELARLLKPGGLLLLST 124
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 37-132 2.44e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 90.32  E-value: 2.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   37 ILELACGTGALAVAFAKD-GYKVTGLDLSEEMLMIASQRAYEEDASIQFVEGNMLDLS-EIGQYQAITCfSDSLCYMkNR 114
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPfPDGSFDLVVS-SGVLHHL-PD 78

                          90
                  ....*....|....*...
gi 488256981  115 QEVQQVFDEVYQALEENG 132
Cdd:pfam13649  79 PDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 10-147 3.29e-22

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 88.90  E-value: 3.29e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  10 YDEVmdETLYQQWLAFSKRHLQEDTKNILELACGTGALAVAFAKDGYKVTGLDLSEEMLMIASQRAYEEDASIQFVEGNM 89
Cdd:COG2226    1 FDRV--AARYDGREALLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEFVVGDA 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488256981  90 LDLS-EIGQYQAITCfSDSLCYMKNRqevQQVFDEVYQALEENGRFLFDVHSTYQVDEF 147
Cdd:COG2226   79 EDLPfPDGSFDLVIS-SFVLHHLPDP---ERALAEIARVLKPGGRLVVVDFSPPDLAEL 133
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
36-138 2.99e-19

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 79.87  E-value: 2.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  36 NILELACGTGALAVAFAK--DGYKVTGLDLSEEMLMIASQRAyeedASIQFVEGNMLDLSEIGQYQAITCfSDSLCYMKN 113
Cdd:COG4106    4 RVLDLGCGTGRLTALLAErfPGARVTGVDLSPEMLARARARL----PNVRFVVADLRDLDPPEPFDLVVS-NAALHWLPD 78

                         90       100
                 ....*....|....*....|....*
gi 488256981 114 RQEvqqVFDEVYQALEENGRFLFDV 138
Cdd:COG4106   79 HAA---LLARLAAALAPGGVLAVQV 100
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 37-136 9.00e-18

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 77.66  E-value: 9.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  37 ILELACGTGALAVAFAKD-GYKVTGLDLSEEMLMIASQRAYEE--DASIQFVEGNMLDLSEIGQYQAITCFsDSLCYMKN 113
Cdd:COG2230   55 VLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAAEAglADRVEVRLADYRDLPADGQFDAIVSI-GMFEHVGP 133

                         90       100
                 ....*....|....*....|...
gi 488256981 114 RqEVQQVFDEVYQALEENGRFLF 136
Cdd:COG2230  134 E-NYPAYFAKVARLLKPGGRLLL 155
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 38-136 6.39e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 70.77  E-value: 6.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   38 LELACGTGALAVAFAKDGYKVTGLDLSEEMLMIASQRAyeEDASIQFVEGNMLDLS-EIGQYQAITCFsDSLCYMKNRqe 116
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKA--PREGLTFVVGDAEDLPfPDNSFDLVLSS-EVLHHVEDP-- 75

                          90       100
                  ....*....|....*....|
gi 488256981  117 vQQVFDEVYQALEENGRFLF 136
Cdd:pfam08241  76 -ERALREIARVLKPGGILII 94
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 23-141 1.95e-15

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 72.26  E-value: 1.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  23 LAFSKRHLQEDTKnILELACGTGALAVAFAK-DGYKVTGLDLSEEMLMIASQRAYEEDAS-IQFVEGNMLDLSEI--GQY 98
Cdd:COG0500   17 LLALLERLPKGGR-VLDLGCGTGRNLLALAArFGGRVIGIDLSPEAIALARARAAKAGLGnVEFLVADLAELDPLpaESF 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 488256981  99 QAITCFsDSLCYMkNRQEVQQVFDEVYQALEENGRFLFDVHST 141
Cdd:COG0500   96 DLVVAF-GVLHHL-PPEEREALLRELARALKPGGVLLLSASDA 136
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 36-138 2.95e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 66.68  E-value: 2.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  36 NILELACGTGALAVAFAKD-GYKVTGLDLSEEMLMIASQRAYEEDAS-IQFVEGNMLDLS--EIGQYQAITCfsdSLCYM 111
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEELPpeADESFDVIIS---DPPLH 77

                         90       100
                 ....*....|....*....|....*..
gi 488256981 112 KNRQEVQQVFDEVYQALEENGRFLFDV 138
Cdd:cd02440   78 HLVEDLARFLEEARRLLKPGGVLVLTL 104
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 38-134 1.15e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 59.69  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   38 LELACGTGALAVAFAK--DGYKVTGLDLSEEMLMIASQR-AYEEDASIQFVEGNMLDLSE--IGQYQAITCFSdSLCYMK 112
Cdd:pfam08242   1 LEIGCGTGTLLRALLEalPGLEYTGLDISPAALEAARERlAALGLLNAVRVELFQLDLGEldPGSFDVVVASN-VLHHLA 79

                          90       100
                  ....*....|....*....|..
gi 488256981  113 NRqevQQVFDEVYQALEENGRF 134
Cdd:pfam08242  80 DP---RAVLRNIRRLLKPGGVL 98
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 36-92 2.51e-11

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 61.71  E-value: 2.51e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488256981  36 NILELACGTGALAVAFAKDGYK---VTGLDLSEEMLMIASQRAYEEDAS--IQFVEGNMLDL 92
Cdd:PRK00216  54 KVLDLACGTGDLAIALAKAVGKtgeVVGLDFSEGMLAVGREKLRDLGLSgnVEFVQGDAEAL 115
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 11-108 4.37e-11

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 60.62  E-value: 4.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  11 DEVMDETLyqQWLafsKRHLQEDTKNILELACGTGALAVAFAKDGYKVTGLDLSEEMLMIASQRAYEE--DASIQFVEGn 88
Cdd:PRK07580  46 QRMRDTVL--SWL---PADGDLTGLRILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAglAGNITFEVG- 119

                         90       100
                 ....*....|....*....|.
gi 488256981  89 mlDLSEI-GQYQAITCFsDSL 108
Cdd:PRK07580 120 --DLESLlGRFDTVVCL-DVL 137
PRK08317 PRK08317
hypothetical protein; Provisional
 19-133 1.14e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 54.17  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  19 YQQWlAFSKRHLQE-DTknILELACGTGALAVAFA----KDGyKVTGLDLSEEMLMIASQRAYEEDASIQFVEGNMLDLS 93
Cdd:PRK08317   7 YRAR-TFELLAVQPgDR--VLDVGCGPGNDARELArrvgPEG-RVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLP 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488256981  94 EIGQYQAITCFSDSLCYMKNrqeVQQVFDEVYQALEENGR 133
Cdd:PRK08317  83 FPDGSFDAVRSDRVLQHLED---PARALAEIARVLRPGGR 119
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 31-153 1.75e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 52.43  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   31 QEDTKNILELACGTGALAVAFAKDGYKVTGLDLSEEMLMIASqrayeeDASIQFVEGNMLDLSEIGQYQAITCFsDSLCY 110
Cdd:pfam13489  20 LPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERAL------LNVRFDQFDEQEAAVPAGKFDVIVAR-EVLEH 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 488256981  111 MKNRQEvqqVFDEVYQALEENGRFLFDVH-STYQVDEFFPEYSY 153
Cdd:pfam13489  93 VPDPPA---LLRQIAALLKPGGLLLLSTPlASDEADRLLLEWPY 133
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 27-103 2.24e-08

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 53.62  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  27 KRHLQEDTKNILELACGTGALAVAFAK--DGYKVTGLDLSEEMLMIASQ--RAYEEDASIQFVEGNMLD-LSEIGQYQAI 101
Cdd:COG2890  106 ALLPAGAPPRVLDLGTGSGAIALALAKerPDARVTAVDISPDALAVARRnaERLGLEDRVRFLQGDLFEpLPGDGRFDLI 185


                 ..
gi 488256981 102 TC 103
Cdd:COG2890  186 VS 187
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 27-101 2.37e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 50.55  E-value: 2.37e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488256981  27 KRHLQEDTKNILELACGTGALAVAFAK--DGYKVTGLDLSEEMLMIASQ-RAYEEDASIQFVEGNMLDLSEIGQYQAI 101
Cdd:PRK09328 102 EALLLKEPLRVLDLGTGSGAIALALAKerPDAEVTAVDISPEALAVARRnAKHGLGARVEFLQGDWFEPLPGGRFDLI 179
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
22-101 3.99e-07

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 49.13  E-value: 3.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  22 WLAFSKRHLQEDTknILELACGTGALAVAFAKDG-YKVTGLDLSEEMLMIASQRAYEEDASIQFVEGNMLDLSEIGQYQA 100
Cdd:COG2263   36 HLAYLRGDIEGKT--VLDLGCGTGMLAIGAALLGaKKVVGVDIDPEALEIARENAERLGVRVDFIRADVTRIPLGGSVDT 113


                 .
gi 488256981 101 I 101
Cdd:COG2263  114 V 114
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
36-135 5.11e-07

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 48.97  E-value: 5.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   36 NILELACGTGALAVAFAK---DGYKVTGLDLSEEMLMIASQRAYEEDAS-IQFVEGNMLDLSEI-GQYQAITC-FSdslc 109
Cdd:pfam01209  45 KFLDVAGGTGDWTFGLSDsagSSGKVVGLDINENMLKEGEKKAKEEGKYnIEFLQGNAEELPFEdDSFDIVTIsFG---- 120

                          90       100
                  ....*....|....*....|....*.
gi 488256981  110 yMKNRQEVQQVFDEVYQALEENGRFL 135
Cdd:pfam01209 121 -LRNFPDYLKVLKEAFRVLKPGGRVV 145
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 35-135 1.10e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 47.03  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   35 KNILELACGTGALAVAFAK---DGYKVTGLDLSEEMLMIASQRAYEEDAS-IQFVEGNMLDLSEIGQYQA--ITCFSDSL 108
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELAEelgPNAEVVGIDISEEAIEKARENAQKLGFDnVEFEQGDIEELPELLEDDKfdVVISNCVL 84

                          90       100
                  ....*....|....*....|....*..
gi 488256981  109 CYMKNRqevQQVFDEVYQALEENGRFL 135
Cdd:pfam13847  85 NHIPDP---DKVLQEILRVLKPGGRLI 108
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 42-114 6.16e-06

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 46.39  E-value: 6.16e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488256981  42 CGTGALAVAFAKDGYKVTGLDLSEEMLMIASQRAYEE---DASIQFVEGNMLDLSEI-GQYQAITCFSDSLCYMKNR 114
Cdd:PLN02585 153 CGTGSLAIPLALEGAIVSASDISAAMVAEAERRAKEAlaaLPPEVLPKFEANDLESLsGKYDTVTCLDVLIHYPQDK 229
PRK06202 PRK06202
hypothetical protein; Provisional
 11-103 1.61e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 41.52  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  11 DEVMD---------ETLYQQ----------WLAFSKRHL-----QEDTKNILELACGTGALAVAFA----KDGYK--VTG 60
Cdd:PRK06202  14 PEVMDdpgcdparlDRTYAGfrrvnrivagWRGLYRRLLrpalsADRPLTLLDIGCGGGDLAIDLArwarRDGLRleVTA 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 488256981  61 LDLSEEMLMIASQRAYEEDASI-QFVEGNMLDLSEigQYQAITC 103
Cdd:PRK06202  94 IDPDPRAVAFARANPRRPGVTFrQAVSDELVAEGE--RFDVVTS 135
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 32-148 2.80e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.90  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981  32 EDTKNILELACGTGALAVAFAK--DGYKVTGLDLSEEMLMIAsQRAYEE---DASIQFVEGNMLDLSEI---GQYQAITC 103
Cdd:COG4123   36 KKGGRVLDLGTGTGVIALMLAQrsPGARITGVEIQPEAAELA-RRNVALnglEDRITVIHGDLKEFAAElppGSFDLVVS 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981 104 ---FSDSLCYMKN--------RQEV----QQVFDEVYQALEENGRFLFdVHSTYQVDEFF 148
Cdd:COG4123  115 nppYFKAGSGRKSpdearaiaRHEDaltlEDLIRAAARLLKPGGRFAL-IHPAERLAEIL 173
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 31-102 6.89e-04

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 40.03  E-value: 6.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488256981   31 QEDTKNILELACGTGALAVAFAKD--GYKVTGLDLSEEMLMIASQRAYEEDAS--IQFVEGNMLDLSEIGQYQAIT 102
Cdd:TIGR00536 112 QPPILHILDLGTGSGCIALALAYEfpNAEVIAVDISPDALAVAEENAEKNQLEhrVEFIQSNLFEPLAGQKIDIIV 187
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 36-92 3.57e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 37.95  E-value: 3.57e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488256981  36 NILELACGTGALAVAFAK----DGyKVTGLDLSEEMLMIASQRAYEEDAS----IQFVEGNMLDL 92
Cdd:PLN02233  76 RVLDLCCGSGDLAFLLSEkvgsDG-KVMGLDFSSEQLAVAASRQELKAKScyknIEWIEGDATDL 139
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
36-89 4.09e-03

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 37.64  E-value: 4.09e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488256981  36 NILELACGTGALAVAFAKDGYKVTGLDLSEEMLmiasQRAyEEDASIQFVEGNM 89
Cdd:PRK11036  47 RVLDAGGGEGQTAIKLAELGHQVILCDLSAEMI----QRA-KQAAEAKGVSDNM 95
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 29-103 4.16e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.80  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488256981   29 HLQED-TKNILELACGTGALAVAFAKDGYKVTgLDLSEEMLM-IASQRAYEED---ASIQFVEGNMLDLSEIGQYQAITC 103
Cdd:pfam05175  26 HLPKDlSGKVLDLGCGAGVLGAALAKESPDAE-LTMVDINARaLESARENLAAnglENGEVVASDVYSGVEDGKFDLIIS 104
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 16-67 4.72e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 37.85  E-value: 4.72e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488256981  16 ETLYQQ---WLAfskrhlQEDTKNILELACGTGALAVAFAKDGYKVTGLDLSEEM 67
Cdd:COG2265  219 EALYAAaleWLD------LTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEA 267
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 31-89 5.57e-03

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 37.04  E-value: 5.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488256981  31 QEDTKNILELACGTGALAVAFAKDGYKVTGLDLSEEMLmiasQRAYEEDASIQFVEGNM 89
Cdd:PRK10258  40 QRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPML----AQARQKDAADHYLAGDI 94
PRK14968 PRK14968
putative methyltransferase; Provisional
 32-91 5.91e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 36.80  E-value: 5.91e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488256981  32 EDTKNILELACGTGALAVAFAKDGYKVTGLDLSE---EMLMIASQRAYEEDASIQFVEGNMLD 91
Cdd:PRK14968  22 KKGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPyavECAKCNAKLNNIRNNGVEVIRSDLFE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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