NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|488257774|ref|WP_002328982|]
View 

MULTISPECIES: cysteine desulfurase family protein [Enterococcus]

Protein Classification

cysteine desulfurase family protein( domain architecture ID 10003004)

cysteine desulfurase family protein is a pyridoxal-5'-phoshate dependent enzyme, similar to cysteine desulfurase that catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine;

CATH:  3.40.640.10
Gene Ontology:  GO:0030170
PubMed:  10800595
SCOP:  3000954

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NifS COG1104
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ...
 1-379 0e+00

Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];


:

Pssm-ID: 440721 [Multi-domain]  Cd Length: 381  Bit Score: 521.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   1 MIYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSLHDLGNQANRLLQQARKQIADLIHAEPEEIFFTSGGTEGDNWVLKGT 80
Cdd:COG1104    3 MIYLDNAATTPVDPEVLEAMLPYLTEYFGNPSSLHSFGREARAALEEAREQVAALLGADPEEIIFTSGGTEANNLAIKGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  81 MIEKREYGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQEI 160
Cdd:COG1104   83 ARAYRKKGKHIITSAIEHPAVLETARFLEKEGFEVTYLPVDEDGRVDLEALEAALRPDTALVSVMHANNETGTIQPIAEI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 161 SDLLNDFpKIHFHVDAVQAIGKVP--FSQWltgRVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQRSGTE 238
Cdd:COG1104  163 AEIAKEH-GVLFHTDAVQAVGKIPvdVKEL---GVDLLSLSAHKIYGPKGVGALYVRKGVRLEPLIHGGGQERGLRSGTE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 239 NVPGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKS-YDKVTIFSEGTDYAPHILCFALKGIRGEVLVHALEEKQIF 317
Cdd:COG1104  239 NVPGIVGLGKAAELAAEELEEEAARLRALRDRLEEGLLAaIPGVVINGDPENRLPNTLNFSFPGVEGEALLLALDLAGIA 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488257774 318 VSTTSACSSRKHMASSTLHAMHVPNDLATSAIRISLDENNSLAEVEQFMIIFKQLYKKFSAI 379
Cdd:COG1104  319 VSSGSACSSGSLEPSHVLLAMGLDEELAHGSIRFSLGRFTTEEEIDRAIEALKEIVARLRKL 380
 
Name Accession Description Interval E-value
NifS COG1104
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ...
 1-379 0e+00

Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];


Pssm-ID: 440721 [Multi-domain]  Cd Length: 381  Bit Score: 521.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   1 MIYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSLHDLGNQANRLLQQARKQIADLIHAEPEEIFFTSGGTEGDNWVLKGT 80
Cdd:COG1104    3 MIYLDNAATTPVDPEVLEAMLPYLTEYFGNPSSLHSFGREARAALEEAREQVAALLGADPEEIIFTSGGTEANNLAIKGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  81 MIEKREYGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQEI 160
Cdd:COG1104   83 ARAYRKKGKHIITSAIEHPAVLETARFLEKEGFEVTYLPVDEDGRVDLEALEAALRPDTALVSVMHANNETGTIQPIAEI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 161 SDLLNDFpKIHFHVDAVQAIGKVP--FSQWltgRVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQRSGTE 238
Cdd:COG1104  163 AEIAKEH-GVLFHTDAVQAVGKIPvdVKEL---GVDLLSLSAHKIYGPKGVGALYVRKGVRLEPLIHGGGQERGLRSGTE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 239 NVPGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKS-YDKVTIFSEGTDYAPHILCFALKGIRGEVLVHALEEKQIF 317
Cdd:COG1104  239 NVPGIVGLGKAAELAAEELEEEAARLRALRDRLEEGLLAaIPGVVINGDPENRLPNTLNFSFPGVEGEALLLALDLAGIA 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488257774 318 VSTTSACSSRKHMASSTLHAMHVPNDLATSAIRISLDENNSLAEVEQFMIIFKQLYKKFSAI 379
Cdd:COG1104  319 VSSGSACSSGSLEPSHVLLAMGLDEELAHGSIRFSLGRFTTEEEIDRAIEALKEIVARLRKL 380
PLN02651 PLN02651
cysteine desulfurase
 2-363 7.33e-102

cysteine desulfurase


Pssm-ID: 178257 [Multi-domain]  Cd Length: 364  Bit Score: 305.43  E-value: 7.33e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSL-HDLGNQANRLLQQARKQIADLIHAEPEEIFFTSGGTEGDNWVLKGT 80
Cdd:PLN02651   1 LYLDMQATTPIDPRVLDAMLPFLIEHFGNPHSRtHLYGWESEDAVEKARAQVAALIGADPKEIIFTSGATESNNLAIKGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  81 MIEKREYGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQEI 160
Cdd:PLN02651  81 MHFYKDKKKHVITTQTEHKCVLDSCRHLQQEGFEVTYLPVKSDGLVDLDELAAAIRPDTALVSVMAVNNEIGVIQPVEEI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 161 SDLLNDFpKIHFHVDAVQAIGKVPFSQWLTGrVDFATFSAHKFHGPRGTGFIYWKKGR--RLAPLLTGGGQERNQRSGTE 238
Cdd:PLN02651 161 GELCREK-KVLFHTDAAQAVGKIPVDVDDLG-VDLMSISGHKIYGPKGVGALYVRRRPrvRLEPLMSGGGQERGRRSGTE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 239 NVPGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKS-YDKVTI--FSEGTDYAPHILCFALKGIRGEVLVHALeeKQ 315
Cdd:PLN02651 239 NTPLVVGLGAACELAMKEMDYDEKHMKALRERLLNGLRAkLGGVRVngPRDPEKRYPGTLNLSFAYVEGESLLMGL--KE 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 488257774 316 IFVSTTSACSSRKHMASSTLHAMHVPNDLATSAIRISLDENNSLAEVE 363
Cdd:PLN02651 317 VAVSSGSACTSASLEPSYVLRALGVPEEMAHGSLRLGVGRFTTEEEVD 364
nifS_epsilon TIGR03403
cysteine desulfurase, NifS family, epsilon proteobacteria type; Members of this family are the ...
 2-380 1.44e-97

cysteine desulfurase, NifS family, epsilon proteobacteria type; Members of this family are the NifS-like cysteine desulfurase of the epsilon division of the Proteobacteria, similar to the NifS protein of nitrogen-fixing bacteria. Like NifS, and unlike IscS, this protein is found as part of a system of just two proteins, a cysteine desulfurase and a scaffold, for iron-sulfur cluster biosynthesis. This protein is called NifS by Olsen, et al. (), so we use this designation.


Pssm-ID: 132444  Cd Length: 382  Bit Score: 295.22  E-value: 1.44e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774    2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSLHDLGNQANRLLQQARKQIADLIHA-EPEEIFFTSGGTEGDNWVLKGT 80
Cdd:TIGR03403   1 VYLDNNATTMLDPKVKELMDPFFCDIYGNPNSLHQFGTATHPAIAEALDKLYKGINArDLDDIIITSCATESNNWVLKGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   81 ---MIEKREyGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPI 157
Cdd:TIGR03403  81 yfdEILKGG-KNHIITTEVEHPAVRATCAFLESLGVEVTYLPINEQGTITAEQVREAITEKTALVSVMWANNETGMIFPI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  158 QEISDLLNDFpKIHFHVDAVQAIGKVPFSQwLTGRVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQRSGT 237
Cdd:TIGR03403 160 KEIGEICKER-GVLFHTDAVQAIGKIPVDV-QKAGVDFLSFSAHKFHGPKGVGGLYIRKGVELTPLFHGGEHMGGRRSGT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  238 ENVPGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKSYDKVTIFSEGTDYAPHILCFALKGIRGEVLVHALEEKQIF 317
Cdd:TIGR03403 238 LNVPYIVAMGEAMRLANEYLDFEKSHVRRLRDRLEDALLELPDVFVVGDREHRVPNTILISIKGVEGEAMLWDLNKAGIA 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488257774  318 VSTTSACSSRKHMASSTLHAMHVPNDLATSAIRISLDENNSLAEVEQFMIIFKQLYKKFSAIN 380
Cdd:TIGR03403 318 ASTGSACASEDLEANPVMVAIGADKELAHTAIRLSLSRFTTEEEIDYTIEVFKKAVQRLRAIS 380
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 2-365 1.80e-80

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 251.01  E-value: 1.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774    2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNP-SSLHDLGNQANRLLQQARKQIADLIHAE-PEEIFFTSGGTEGDNWVLKG 79
Cdd:pfam00266   1 IYLDSAATTQKPQEVLDAIQEYYTDYNGNVhRGVHTLGKEATQAYEEAREKVAEFINAPsNDEIIFTSGTTEAINLVALS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   80 TMIEKREyGNHMIISGIEHPAVSETAEQL-KELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQ 158
Cdd:pfam00266  81 LGRSLKP-GDEIVITEMEHHANLVPWQELaKRTGARVRVLPLDEDGLLDLDELEKLITPKTKLVAITHVSNVTGTIQPVP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  159 EISDLLNDFpKIHFHVDAVQAIGKVPFSQWLTGrVDFATFSAHKFHGPRGTGFIYWKK--GRRLAPLLTGGG-------Q 229
Cdd:pfam00266 160 EIGKLAHQY-GALVLVDAAQAIGHRPIDVQKLG-VDFLAFSGHKLYGPTGIGVLYGRRdlLEKMPPLLGGGGmietvslQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  230 ERNQ-------RSGTENVPGIVAMAKALRLSLEI-KEQKPEQTQRLKEALIHALKSYDKVTIFseGTDYAPHILCFALKG 301
Cdd:pfam00266 238 ESTFadapwkfEAGTPNIAGIIGLGAALEYLSEIgLEAIEKHEHELAQYLYERLLSLPGIRLY--GPERRASIISFNFKG 315

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488257774  302 IRGEVLVHALEEKQIFVSTTSACSsrkhMASSTLHAMHvpndlatSAIRISLDENNSLAEVEQF 365
Cdd:pfam00266 316 VHPHDVATLLDESGIAVRSGHHCA----QPLMVRLGLG-------GTVRASFYIYNTQEDVDRL 368
SufS_like cd06453
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ...
 2-365 3.33e-52

Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.


Pssm-ID: 99746 [Multi-domain]  Cd Length: 373  Bit Score: 177.66  E-value: 3.33e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNPS-SLHDLGNQANRLLQQARKQIADLIHAE-PEEIFFTSGGTEGDNWVLKG 79
Cdd:cd06453    1 VYLDNAATSQKPQPVIDAIVDYYRHYNANVHrGVHELSARATDAYEAAREKVARFINAPsPDEIIFTRNTTEAINLVAYG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  80 tMIEKREYGNHMIISGIEHPAVSETAEQL-KELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQ 158
Cdd:cd06453   81 -LGRANKPGDEIVTSVMEHHSNIVPWQQLaERTGAKLKVVPVDDDGQLDLEALEKLLTERTKLVAVTHVSNVLGTINPVK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 159 EISDLLNDFpKIHFHVDAVQAIGKVPFS-QWLtgRVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQR--- 234
Cdd:cd06453  160 EIGEIAHEA-GVPVLVDGAQSAGHMPVDvQDL--GCDFLAFSGHKMLGPTGIGVLYGKEELLEEMPPYGGGGEMIEEvsf 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 235 -------------SGTENVPGIVAMAKALRLSLEI-KEQKPEQTQRLKEALIHALKSYDKVTIFSEGTDYAPhILCFALK 300
Cdd:cd06453  237 eettyadlphkfeAGTPNIAGAIGLGAAIDYLEKIgMEAIAAHEHELTAYALERLSEIPGVRVYGDAEDRAG-VVSFNLE 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488257774 301 GIRGEVLVHALEEKQIfvsttsACSSRKHMASSTLHAMHVPndlatSAIRISLDENNSLAEVEQF 365
Cdd:cd06453  316 GIHPHDVATILDQYGI------AVRAGHHCAQPLMRRLGVP-----GTVRASFGLYNTEEEIDAL 369
 
Name Accession Description Interval E-value
NifS COG1104
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ...
 1-379 0e+00

Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];


Pssm-ID: 440721 [Multi-domain]  Cd Length: 381  Bit Score: 521.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   1 MIYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSLHDLGNQANRLLQQARKQIADLIHAEPEEIFFTSGGTEGDNWVLKGT 80
Cdd:COG1104    3 MIYLDNAATTPVDPEVLEAMLPYLTEYFGNPSSLHSFGREARAALEEAREQVAALLGADPEEIIFTSGGTEANNLAIKGA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  81 MIEKREYGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQEI 160
Cdd:COG1104   83 ARAYRKKGKHIITSAIEHPAVLETARFLEKEGFEVTYLPVDEDGRVDLEALEAALRPDTALVSVMHANNETGTIQPIAEI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 161 SDLLNDFpKIHFHVDAVQAIGKVP--FSQWltgRVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQRSGTE 238
Cdd:COG1104  163 AEIAKEH-GVLFHTDAVQAVGKIPvdVKEL---GVDLLSLSAHKIYGPKGVGALYVRKGVRLEPLIHGGGQERGLRSGTE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 239 NVPGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKS-YDKVTIFSEGTDYAPHILCFALKGIRGEVLVHALEEKQIF 317
Cdd:COG1104  239 NVPGIVGLGKAAELAAEELEEEAARLRALRDRLEEGLLAaIPGVVINGDPENRLPNTLNFSFPGVEGEALLLALDLAGIA 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488257774 318 VSTTSACSSRKHMASSTLHAMHVPNDLATSAIRISLDENNSLAEVEQFMIIFKQLYKKFSAI 379
Cdd:COG1104  319 VSSGSACSSGSLEPSHVLLAMGLDEELAHGSIRFSLGRFTTEEEIDRAIEALKEIVARLRKL 380
PLN02651 PLN02651
cysteine desulfurase
 2-363 7.33e-102

cysteine desulfurase


Pssm-ID: 178257 [Multi-domain]  Cd Length: 364  Bit Score: 305.43  E-value: 7.33e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSL-HDLGNQANRLLQQARKQIADLIHAEPEEIFFTSGGTEGDNWVLKGT 80
Cdd:PLN02651   1 LYLDMQATTPIDPRVLDAMLPFLIEHFGNPHSRtHLYGWESEDAVEKARAQVAALIGADPKEIIFTSGATESNNLAIKGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  81 MIEKREYGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQEI 160
Cdd:PLN02651  81 MHFYKDKKKHVITTQTEHKCVLDSCRHLQQEGFEVTYLPVKSDGLVDLDELAAAIRPDTALVSVMAVNNEIGVIQPVEEI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 161 SDLLNDFpKIHFHVDAVQAIGKVPFSQWLTGrVDFATFSAHKFHGPRGTGFIYWKKGR--RLAPLLTGGGQERNQRSGTE 238
Cdd:PLN02651 161 GELCREK-KVLFHTDAAQAVGKIPVDVDDLG-VDLMSISGHKIYGPKGVGALYVRRRPrvRLEPLMSGGGQERGRRSGTE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 239 NVPGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKS-YDKVTI--FSEGTDYAPHILCFALKGIRGEVLVHALeeKQ 315
Cdd:PLN02651 239 NTPLVVGLGAACELAMKEMDYDEKHMKALRERLLNGLRAkLGGVRVngPRDPEKRYPGTLNLSFAYVEGESLLMGL--KE 316

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 488257774 316 IFVSTTSACSSRKHMASSTLHAMHVPNDLATSAIRISLDENNSLAEVE 363
Cdd:PLN02651 317 VAVSSGSACTSASLEPSYVLRALGVPEEMAHGSLRLGVGRFTTEEEVD 364
nifS_epsilon TIGR03403
cysteine desulfurase, NifS family, epsilon proteobacteria type; Members of this family are the ...
 2-380 1.44e-97

cysteine desulfurase, NifS family, epsilon proteobacteria type; Members of this family are the NifS-like cysteine desulfurase of the epsilon division of the Proteobacteria, similar to the NifS protein of nitrogen-fixing bacteria. Like NifS, and unlike IscS, this protein is found as part of a system of just two proteins, a cysteine desulfurase and a scaffold, for iron-sulfur cluster biosynthesis. This protein is called NifS by Olsen, et al. (), so we use this designation.


Pssm-ID: 132444  Cd Length: 382  Bit Score: 295.22  E-value: 1.44e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774    2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSLHDLGNQANRLLQQARKQIADLIHA-EPEEIFFTSGGTEGDNWVLKGT 80
Cdd:TIGR03403   1 VYLDNNATTMLDPKVKELMDPFFCDIYGNPNSLHQFGTATHPAIAEALDKLYKGINArDLDDIIITSCATESNNWVLKGV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   81 ---MIEKREyGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPI 157
Cdd:TIGR03403  81 yfdEILKGG-KNHIITTEVEHPAVRATCAFLESLGVEVTYLPINEQGTITAEQVREAITEKTALVSVMWANNETGMIFPI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  158 QEISDLLNDFpKIHFHVDAVQAIGKVPFSQwLTGRVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQRSGT 237
Cdd:TIGR03403 160 KEIGEICKER-GVLFHTDAVQAIGKIPVDV-QKAGVDFLSFSAHKFHGPKGVGGLYIRKGVELTPLFHGGEHMGGRRSGT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  238 ENVPGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKSYDKVTIFSEGTDYAPHILCFALKGIRGEVLVHALEEKQIF 317
Cdd:TIGR03403 238 LNVPYIVAMGEAMRLANEYLDFEKSHVRRLRDRLEDALLELPDVFVVGDREHRVPNTILISIKGVEGEAMLWDLNKAGIA 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488257774  318 VSTTSACSSRKHMASSTLHAMHVPNDLATSAIRISLDENNSLAEVEQFMIIFKQLYKKFSAIN 380
Cdd:TIGR03403 318 ASTGSACASEDLEANPVMVAIGADKELAHTAIRLSLSRFTTEEEIDYTIEVFKKAVQRLRAIS 380
PRK14012 PRK14012
IscS subfamily cysteine desulfurase;
2-353 4.88e-92

IscS subfamily cysteine desulfurase;


Pssm-ID: 184450 [Multi-domain]  Cd Length: 404  Bit Score: 281.83  E-value: 4.88e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   2 IYFDNSATTPIFPQSLDAYVK--TSQRIIGNPSSL-HDLGNQANRLLQQARKQIADLIHAEPEEIFFTSGGTEGDNWVLK 78
Cdd:PRK14012   5 IYLDYSATTPVDPRVAEKMMPylTMDGTFGNPASRsHRFGWQAEEAVDIARNQIADLIGADPREIVFTSGATESDNLAIK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  79 GTMIEKREYGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQ 158
Cdd:PRK14012  85 GAAHFYQKKGKHIITSKTEHKAVLDTCRQLEREGFEVTYLDPQSNGIIDLEKLEAAMRDDTILVSIMHVNNEIGVIQDIA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 159 EISDLLNDfPKIHFHVDAVQAIGKVPFS-QWLtgRVDFATFSAHKFHGPRGTGFIY-WKKGR-RLAPLLTGGGQERNQRS 235
Cdd:PRK14012 165 AIGEICRE-RGIIFHVDAAQSVGKVPIDlSKL--KVDLMSFSAHKIYGPKGIGALYvRRKPRvRLEAQMHGGGHERGMRS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 236 GTENVPGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKSYDKVTIFSEGTDYAPHILCFALKGIRGEVLVHALeeKQ 315
Cdd:PRK14012 242 GTLPTHQIVGMGEAARIAKEEMATENERIRALRDRLWNGIKDIEEVYLNGDLEQRVPGNLNVSFNYVEGESLIMAL--KD 319

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 488257774 316 IFVSTTSACSSRKHMASSTLHAMHVPNDLATSAIRISL 353
Cdd:PRK14012 320 LAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSL 357
PRK02948 PRK02948
IscS subfamily cysteine desulfurase;
1-376 9.51e-90

IscS subfamily cysteine desulfurase;


Pssm-ID: 179511 [Multi-domain]  Cd Length: 381  Bit Score: 275.07  E-value: 9.51e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   1 MIYFDNSATTPIFPQSLDAYVKTSQRIIGNPSSLHDLGNQANRLLQQARKQIADLIHAEPEEIFFTSGGTEGDNWVLKGT 80
Cdd:PRK02948   1 MIYLDYAATTPMSKEALQTYQKAASQYFGNESSLHDIGGTASSLLQVCRKTFAEMIGGEEQGIYFTSGGTESNYLAIQSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  81 MIEKREYGNHMIISGIEHPAVSETAEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQEI 160
Cdd:PRK02948  81 LNALPQNKKHIITTPMEHASIHSYFQSLESQGYTVTEIPVDKSGLIRLVDLERAITPDTVLASIQHANSEIGTIQPIAEI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 161 SDLLNDFpKIHFHVDAVQAIGKVPFSQWLTGrVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQRSGTENV 240
Cdd:PRK02948 161 GALLKKY-NVLFHSDCVQTFGKLPIDVFEMG-IDSLSVSAHKIYGPKGVGAVYINPQVRWKPVFPGTTHEKGFRPGTVNV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 241 PGIVAMAKALRLSLEIKEQKPEQTQRLKEALIHALKSYD-KVTIFSEGTDYAPHILCFALKGIRGEVLVHALEEKQIFVS 319
Cdd:PRK02948 239 PGIAAFLTAAENILKNMQEESLRFKELRSYFLEQIQTLPlPIEVEGHSTSCLPHIIGVTIKGIEGQYTMLECNRRGIAIS 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488257774 320 TTSACSSRKHMASSTLHAMHVPNDLATSAIRISLDENNSLAEVEQFMIIFKQLYKKF 376
Cdd:PRK02948 319 TGSACQVGKQEPSKTMLAIGKTYEEAKQFVRFSFGQQTTKDQIDTTIHALETIGNQF 375
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 2-365 1.80e-80

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 251.01  E-value: 1.80e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774    2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNP-SSLHDLGNQANRLLQQARKQIADLIHAE-PEEIFFTSGGTEGDNWVLKG 79
Cdd:pfam00266   1 IYLDSAATTQKPQEVLDAIQEYYTDYNGNVhRGVHTLGKEATQAYEEAREKVAEFINAPsNDEIIFTSGTTEAINLVALS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   80 TMIEKREyGNHMIISGIEHPAVSETAEQL-KELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQ 158
Cdd:pfam00266  81 LGRSLKP-GDEIVITEMEHHANLVPWQELaKRTGARVRVLPLDEDGLLDLDELEKLITPKTKLVAITHVSNVTGTIQPVP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  159 EISDLLNDFpKIHFHVDAVQAIGKVPFSQWLTGrVDFATFSAHKFHGPRGTGFIYWKK--GRRLAPLLTGGG-------Q 229
Cdd:pfam00266 160 EIGKLAHQY-GALVLVDAAQAIGHRPIDVQKLG-VDFLAFSGHKLYGPTGIGVLYGRRdlLEKMPPLLGGGGmietvslQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  230 ERNQ-------RSGTENVPGIVAMAKALRLSLEI-KEQKPEQTQRLKEALIHALKSYDKVTIFseGTDYAPHILCFALKG 301
Cdd:pfam00266 238 ESTFadapwkfEAGTPNIAGIIGLGAALEYLSEIgLEAIEKHEHELAQYLYERLLSLPGIRLY--GPERRASIISFNFKG 315

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488257774  302 IRGEVLVHALEEKQIFVSTTSACSsrkhMASSTLHAMHvpndlatSAIRISLDENNSLAEVEQF 365
Cdd:pfam00266 316 VHPHDVATLLDESGIAVRSGHHCA----QPLMVRLGLG-------GTVRASFYIYNTQEDVDRL 368
CsdA COG0520
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
2-366 1.80e-61

Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];


Pssm-ID: 440286 [Multi-domain]  Cd Length: 396  Bit Score: 202.68  E-value: 1.80e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNPS-SLHDLGNQANRLLQQARKQIADLIHA-EPEEIFFTSGGTEGDNWVLKG 79
Cdd:COG0520   17 VYLDNAATGQKPRPVIDAIRDYYEPYNANVHrGAHELSAEATDAYEAAREKVARFIGAaSPDEIIFTRGTTEAINLVAYG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  80 -TMIEKreyGNHMIISGIEHPAVSETAEQL-KELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPI 157
Cdd:COG0520   97 lGRLKP---GDEILITEMEHHSNIVPWQELaERTGAEVRVIPLDEDGELDLEALEALLTPRTKLVAVTHVSNVTGTVNPV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 158 QEISDLLNDFPkIHFHVDAVQAIGKVPF--SQWltgRVDFATFSAHKFHGPRGTGFIYWKKG--RRLAPLLTGGG----- 228
Cdd:COG0520  174 KEIAALAHAHG-ALVLVDGAQSVPHLPVdvQAL---GCDFYAFSGHKLYGPTGIGVLYGKREllEALPPFLGGGGmiewv 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 229 -------QERNQR--SGTENVPGIVAMAKALRLSLEI-KEQKPEQTQRLKEALIHALKSYDKVTIFSEGtDYAPH--ILC 296
Cdd:COG0520  250 sfdgttyADLPRRfeAGTPNIAGAIGLGAAIDYLEAIgMEAIEARERELTAYALEGLAAIPGVRILGPA-DPEDRsgIVS 328

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 297 FALKGIRGEVLVHALEEKQIFVSTTSACssrkhmASSTLHAMHVPndlatSAIRISLDENNSLAEVEQFM 366
Cdd:COG0520  329 FNVDGVHPHDVAALLDDEGIAVRAGHHC------AQPLMRRLGVP-----GTVRASFHLYNTEEEIDRLV 387
SufS_like cd06453
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ...
 2-365 3.33e-52

Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.


Pssm-ID: 99746 [Multi-domain]  Cd Length: 373  Bit Score: 177.66  E-value: 3.33e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   2 IYFDNSATTPIFPQSLDAYVKTSQRIIGNPS-SLHDLGNQANRLLQQARKQIADLIHAE-PEEIFFTSGGTEGDNWVLKG 79
Cdd:cd06453    1 VYLDNAATSQKPQPVIDAIVDYYRHYNANVHrGVHELSARATDAYEAAREKVARFINAPsPDEIIFTRNTTEAINLVAYG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  80 tMIEKREYGNHMIISGIEHPAVSETAEQL-KELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQ 158
Cdd:cd06453   81 -LGRANKPGDEIVTSVMEHHSNIVPWQQLaERTGAKLKVVPVDDDGQLDLEALEKLLTERTKLVAVTHVSNVLGTINPVK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 159 EISDLLNDFpKIHFHVDAVQAIGKVPFS-QWLtgRVDFATFSAHKFHGPRGTGFIYWKKGRRLAPLLTGGGQERNQR--- 234
Cdd:cd06453  160 EIGEIAHEA-GVPVLVDGAQSAGHMPVDvQDL--GCDFLAFSGHKMLGPTGIGVLYGKEELLEEMPPYGGGGEMIEEvsf 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 235 -------------SGTENVPGIVAMAKALRLSLEI-KEQKPEQTQRLKEALIHALKSYDKVTIFSEGTDYAPhILCFALK 300
Cdd:cd06453  237 eettyadlphkfeAGTPNIAGAIGLGAAIDYLEKIgMEAIAAHEHELTAYALERLSEIPGVRVYGDAEDRAG-VVSFNLE 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488257774 301 GIRGEVLVHALEEKQIfvsttsACSSRKHMASSTLHAMHVPndlatSAIRISLDENNSLAEVEQF 365
Cdd:cd06453  316 GIHPHDVATILDQYGI------AVRAGHHCAQPLMRRLGVP-----GTVRASFGLYNTEEEIDAL 369
PRK09295 PRK09295
cysteine desulfurase SufS;
34-250 1.14e-21

cysteine desulfurase SufS;


Pssm-ID: 181766 [Multi-domain]  Cd Length: 406  Bit Score: 95.59  E-value: 1.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  34 LHDLGNQANRLLQQARKQIADLIHAE-PEEIFFTSGGTEGDNWVLKGTMIEKREYGNHMIISGIEHPAVSETAEQL-KEL 111
Cdd:PRK09295  58 IHTLSAQATEKMENVRKQAALFINARsAEELVFVRGTTEGINLVANSWGNSNVRAGDNIIISEMEHHANIVPWQMLcARV 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 112 GIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEVGSIQPIQEIsdllndFPKIHFH-----VDAVQAIGKVPFS 186
Cdd:PRK09295 138 GAELRVIPLNPDGTLQLETLPALFDERTRLLAITHVSNVLGTENPLAEM------IALAHQHgakvlVDGAQAVMHHPVD 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 187 -QWLTgrVDFATFSAHKFHGPRGTGFIYWKKGRRLA-PLLTGGGQERNQRS----------------GTENVPGIVAMAK 248
Cdd:PRK09295 212 vQALD--CDFYVFSGHKLYGPTGIGILYVKEALLQEmPPWEGGGSMIATVSltegttwakapwrfeaGTPNTGGIIGLGA 289


                 ..
gi 488257774 249 AL 250
Cdd:PRK09295 290 AL 291
PLN02855 PLN02855
Bifunctional selenocysteine lyase/cysteine desulfurase
 1-227 1.93e-18

Bifunctional selenocysteine lyase/cysteine desulfurase


Pssm-ID: 215460 [Multi-domain]  Cd Length: 424  Bit Score: 86.34  E-value: 1.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   1 MIYFDNSATTPIFPQSLDAYVKTSQRIIGN-PSSLHDLGNQANRLLQQARKQIADLIHAE-PEEIFFTSGGTEGDNWVLK 78
Cdd:PLN02855  33 LVYLDNAATSQKPAAVLDALQDYYEEYNSNvHRGIHALSAKATDAYELARKKVAAFINAStSREIVFTRNATEAINLVAY 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  79 GTMIEKREYGNHMIISGIEHPA-------VSEtaeqlkELGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVMAVNNEV 151
Cdd:PLN02855 113 TWGLANLKPGDEVILSVAEHHSnivpwqlVAQ------KTGAVLKFVGLTPDEVLDVEQLKELLSEKTKLVATHHVSNVL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 152 GSIQPIQEISDLlndfpkIHFH-----VDAVQAIGKVPFSQWLTGrVDFATFSAHKFHGPRGTGFIYWKKG--RRLAPLL 224
Cdd:PLN02855 187 GSILPVEDIVHW------AHAVgakvlVDACQSVPHMPVDVQTLG-ADFLVASSHKMCGPTGIGFLWGKSDllESMPPFL 259


                 ...
gi 488257774 225 TGG 227
Cdd:PLN02855 260 GGG 262
PRK10874 PRK10874
cysteine desulfurase CsdA;
2-250 4.63e-14

cysteine desulfurase CsdA;


Pssm-ID: 182799 [Multi-domain]  Cd Length: 401  Bit Score: 72.76  E-value: 4.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   2 IYFDnSATTPIFPQsldAYVKTSQRIIGNPS-----SLHdlgNQANRLLQ---QARKQIADLIHAE-PEEIFFTSGGTEG 72
Cdd:PRK10874  21 VYLD-SAATALKPQ---AVIEATQQFYSLSAgnvhrSQF---AAAQRLTAryeAAREQVAQLLNAPdAKNIVWTRGTTES 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  73 DNWVLKGTMIEKREYGNHMIISGIEHPA-------VsetAEQLkelGIEVSIAPVDKRGFVRVDELKKLIRKETVLVSVM 145
Cdd:PRK10874  94 INLVAQSYARPRLQPGDEIIVSEAEHHAnlvpwlmV---AQQT---GAKVVKLPLGADRLPDVDLLPELITPRTRILALG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 146 AVNNEVGSiQPiqeisDLLNDFPKIHFH-----VDAVQAI--GKVPFSQWltgRVDFATFSAHKFHGPRGTGFIYWKKGR 218
Cdd:PRK10874 168 QMSNVTGG-CP-----DLARAITLAHQAgmvvmVDGAQGAvhFPADVQAL---DIDFYAFSGHKLYGPTGIGVLYGKSEL 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 488257774 219 --RLAPLLtGGG-------------QERNQR--SGTENVPGIVAMAKAL 250
Cdd:PRK10874 239 leAMSPWQ-GGGkmltevsfdgftpQSAPWRfeAGTPNVAGVIGLSAAL 286
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 53-215 2.24e-11

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 64.53  E-value: 2.24e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  53 ADLIHAEPEEI--FFTSGGTEG---------DNWVLKGTMIEKREYGNHMIISGIE-HPAVSETAEQLkelGIEVSIAPV 120
Cdd:cd06450   48 AKLFGLPSEDAdgVFTSGGSESnllallaarDRARKRLKAGGGRGIDKLVIVCSDQaHVSVEKAAAYL---DVKVRLVPV 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 121 DKRGFVRVDELKKLIRKE------TVLVSVMAVNNEVGSIQPIQEISDLLNDFpKIHFHVDAVQAIGKVPF---SQWLTG 191
Cdd:cd06450  125 DEDGRMDPEALEAAIDEDkaeglnPIMVVATAGTTDTGAIDPLEEIADLAEKY-DLWLHVDAAYGGFLLPFpepRHLDFG 203

                        170       180
                 ....*....|....*....|....*..
gi 488257774 192 --RVDFATFSAHK-FHGPRGTGFIYWK 215
Cdd:cd06450  204 ieRVDSISVDPHKyGLVPLGCSAVLVR 230
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 6-220 3.87e-10

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 61.00  E-value: 3.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   6 NSATTPiFPQSLDAYVKTSqriigNPSSLH-DLGNQANRLLQQARKQIADLIHAePEEIF--FTSGGTEGD--------N 74
Cdd:COG0076   75 TGGTTP-AALAADLLASAL-----NQNMGDwDTSPAATELEREVVRWLADLLGL-PEGAGgvFTSGGTEANllallaarD 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  75 WVLKGTMIEKREYGNH---MIISGIEHPAVSETAEQLkelGIE---VSIAPVDKRGFVRVDELKKLIR------KETVLV 142
Cdd:COG0076  148 RALARRVRAEGLPGAPrprIVVSEEAHSSVDKAARLL---GLGrdaLRKVPVDEDGRMDPDALEAAIDedraagLNPIAV 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 143 --SVMAVNneVGSIQPIQEISDLLNDFpKIHFHVDAvqAIG-----KVPFSQWLTG--RVDFATFSAHK-FHGPRGTGFI 212
Cdd:COG0076  225 vaTAGTTN--TGAIDPLAEIADIAREH-GLWLHVDA--AYGgfalpSPELRHLLDGieRADSITVDPHKwLYVPYGCGAV 299


                 ....*...
gi 488257774 213 YWKKGRRL 220
Cdd:COG0076  300 LVRDPELL 307
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 44-215 7.73e-10

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 57.39  E-value: 7.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  44 LLQQARKQIADLIHAEPEEIFFTSGGTEGDNWVLKGTmiekREYGNHMIISGIEHPAVSETAEQLKelGIEVSIAPVD-- 121
Cdd:cd01494    1 KLEELEEKLARLLQPGNDKAVFVPSGTGANEAALLAL----LGPGDEVIVDANGHGSRYWVAAELA--GAKPVPVPVDda 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 122 KRGFVRVDELKKLIRKE-TVLVSVMAVNNEVGSIQPIQEISDLLNDFpKIHFHVDAVQAIGKVPFSQWLT--GRVDFATF 198
Cdd:cd01494   75 GYGGLDVAILEELKAKPnVALIVITPNTTSGGVLVPLKEIRKIAKEY-GILLLVDAASAGGASPAPGVLIpeGGADVVTF 153

                        170
                 ....*....|....*..
gi 488257774 199 SAHKFHGPRGTGFIYWK 215
Cdd:cd01494  154 SLHKNLGGEGGGVVIVK 170
AGAT_like cd06451
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ...
 105-212 6.58e-06

Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.


Pssm-ID: 99744 [Multi-domain]  Cd Length: 356  Bit Score: 47.67  E-value: 6.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774 105 AEQLKELGIEVSIAPVDKRGFVRVDELKKLIRKETVlVSVMAVNNE--VGSIQPIQEISDLLNDFPKIHFhVDAVQAIGK 182
Cdd:cd06451   90 ADMAERYGADVDVVEKPWGEAVSPEEIAEALEQHDI-KAVTLTHNEtsTGVLNPLEGIGALAKKHDALLI-VDAVSSLGG 167

                         90       100       110
                 ....*....|....*....|....*....|...
gi 488257774 183 VPFS--QWltgRVDFATFSAHK-FHGPRGTGFI 212
Cdd:cd06451  168 EPFRmdEW---GVDVAYTGSQKaLGAPPGLGPI 197
PRK07324 PRK07324
transaminase; Validated
 49-154 3.84e-04

transaminase; Validated


Pssm-ID: 235989  Cd Length: 373  Bit Score: 42.23  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  49 RKQIADLI-HAEPEEIFFTSGGTEGDNWVLKgTMIEKreyGNHMIisgiehpAVSETAEQL----KELGIEVSIAPVD-K 122
Cdd:PRK07324  68 KEAVASLYqNVKPENILQTNGATGANFLVLY-ALVEP---GDHVI-------SVYPTYQQLydipESLGAEVDYWQLKeE 136

                         90       100       110
                 ....*....|....*....|....*....|...
gi 488257774 123 RGFV-RVDELKKLIRKETVLVSVMAVNNEVGSI 154
Cdd:PRK07324 137 NGWLpDLDELRRLVRPNTKLICINNANNPTGAL 169
PLN02724 PLN02724
Molybdenum cofactor sulfurase
 2-128 2.15e-03

Molybdenum cofactor sulfurase


Pssm-ID: 215384 [Multi-domain]  Cd Length: 805  Bit Score: 40.24  E-value: 2.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774   2 IYFDNSATTPIFPQSLDAYVKT-SQRIIGNPSSLHDLGNQANRLLQQARKQIADLIHAEPEE--IFFTSGGT-------E 71
Cdd:PLN02724  36 VYLDHAGATLYSESQLEAALADfSSNVYGNPHSQSDSSMRSSDTIESARQQVLEYFNAPPSDyaCVFTSGATaalklvgE 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488257774  72 GDNWVLKGTMIEKREygNHMIISGIEHPA-----------VSETAEQLKELGIEVSI--APVDKRGFVRV 128
Cdd:PLN02724 116 TFPWSSESHFCYTLE--NHNSVLGIREYAlekgaaaiavdIEEAANQPTNSQGSVVVksRGLQRRNTSKL 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH