|
Name |
Accession |
Description |
Interval |
E-value |
| BglG |
COG3711 |
Transcriptional antiterminator [Transcription]; |
8-675 |
1.29e-71 |
|
Transcriptional antiterminator [Transcription];
Pssm-ID: 442925 [Multi-domain] Cd Length: 618 Bit Score: 244.38 E-value: 1.29e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 8 ILHRIMTAQYPVKAERLAAEFNVSQRTIRQEVLEANIWLSSKKLPEIRTiRNKGFSLKLENDKQVRLETEIKEVKDgFLN 87
Cdd:COG3711 1 ILKILLKNNNVVTAKELAKKLNVSERTIRYDIKKINEWLKKNGLEIISK-KGIGFRLDIDDEQKEKLLQLLEKSED-PLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 88 RRERIFDLVLAIAYSRNPIHLNKKEEEFQISKSTLDEDMRRLRATLVSYGIEIVSYGKQGLVYKGSERSIRTMIYDFINQ 167
Cdd:COG3711 79 PKERVAYILLRLLLAGDPISLDDLAEELFVSRSTILNDLKKIEKILKKYGLTLERKPNYGIKLEGSELDIRKALAELLSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 168 NLGMTDFFmnqdaqltpaQKIFFHYFPLAEIKKIEEI---YSNKLLKQEDDIYKKQILLFTLIWIQRIRKHEFISAINWK 244
Cdd:COG3711 159 LLSENDLL----------SLLLLKLIPEEDLELIEEIieeAEKKLGIKLSDSIYINLTDHIAIAIKRIKKGKYIKLDNPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 245 NTEIKDSSFSAFIDYMITEFQLN---NVPQVERNYLRFTIETFNARDISN--SIEWVQAQLLTIQLIQFVENETHIPFHl 319
Cdd:COG3711 229 LWEIKKPKEYEIAKEILKLIEERlgiSLPEDEIGYIALHLLGARLNNDNElsEIITLEITKLIKEIINIIEEELGIDLD- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 320 KKEALFENLYKHMAALIIRIKHAIQVMNPLKENIRTNYFPIHRAVTHFVPTIEEVIGGKILEDEIAFLVIHFstIASVIK 399
Cdd:COG3711 308 EDSLLYERLITHLKPAINRLKYGIPIRNPLLEEIKEKYPEAFELAKKIAKYLEKELGIEIPEDEIGYLTLHF--GAALER 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 400 RDLNYVYQSVVVCNHGMATGNLLAENLKEKFPQIEITAVLSSKEIELVDKLDVDLIFSTFQLNyrNKPLLVIDPILTETN 479
Cdd:COG3711 386 QKESKKKRVLVVCSSGIGTSRLLKSRLKKLFPEIEIIDVISYRELEEIDLEDYDLIISTVPLE--DKPVIVVSPLLTEED 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 480 ILVIEDFLKRneglqrlkpnshestqlftqiigvmeesggrvdriIYGKLEKLFEINNLeinkreiqpmLKDILTDSNIM 559
Cdd:COG3711 464 IEKIRKFLKQ-----------------------------------IKKKLAKILFELLL----------LLLLLEEKEII 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 560 IKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYIVIGKHMALAHARPEDGVNKLGVSVATIEQPIDFGNP 639
Cdd:COG3711 499 ILLLLLLIEEALAADAIEELEEEEIEEELEEIIIIIVIAIPIIIIIIIAIIVLAAEEPGVIKLILVLLLLLILIILLEDD 578
|
650 660 670
....*....|....*....|....*....|....*.
gi 488258440 640 EMDPVKIIFCLAAVDSYSHLNIMKELIELINNEEKL 675
Cdd:COG3711 579 EALLVILLLLLLLIESSLLLLLLLELLLELELELLI 614
|
|
| PTS_IIA_fru |
cd00211 |
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ... |
553-691 |
1.54e-33 |
|
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.
Pssm-ID: 238129 [Multi-domain] Cd Length: 136 Bit Score: 124.98 E-value: 1.54e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 553 LTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEyGPYIvIGKHMALAHARPEDgVNKLGVSVATIEQ 632
Cdd:cd00211 1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKE-GSTG-IGNGIAIPHAKSEA-VKKPGIAVLRLKE 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 488258440 633 PIDFGNPEMDPVKIIFCLAAVDSYSHLNIMKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:cd00211 78 PVDFGSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
|
|
| PTS_EIIA_2 |
pfam00359 |
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; |
552-691 |
2.84e-31 |
|
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
Pssm-ID: 459780 [Multi-domain] Cd Length: 139 Bit Score: 118.85 E-value: 2.84e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 552 ILTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYIVIGkhMALAHARPEDgVNKLGVSVATIE 631
Cdd:pfam00359 1 LLDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGNG--IAIPHARSEA-VKKPGIAVLTLK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488258440 632 QPIDFGNPEMDPVKIIFCLAAVDSYS-HLNIMKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:pfam00359 78 EPVDFGSEDGKPVKLIFLLAAPDNEAsHLKILSQLARLLQDEEFVEKLLKAKDPEEILEIL 138
|
|
| PRK10372 |
PRK10372 |
PTS ascorbate transporter subunit IIA; |
549-691 |
2.40e-30 |
|
PTS ascorbate transporter subunit IIA;
Pssm-ID: 182417 [Multi-domain] Cd Length: 154 Bit Score: 116.61 E-value: 2.40e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 549 LKDILTDSN-IMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYIVIGKHMALAHARPEDGVNKLGVSV 627
Cdd:PRK10372 3 LRDSLAENKsIRLQAEAETWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFAL 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488258440 628 ATIEQPIDFGNPEMDPVKIIFCLAAVDSYSHLNI-MKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:PRK10372 83 VTLKKPLEFNHEDNDPVDILITMAAVDANTHQEVgIMQIVNLFEDEANFDRLRACRTEQEVLDLI 147
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BglG |
COG3711 |
Transcriptional antiterminator [Transcription]; |
8-675 |
1.29e-71 |
|
Transcriptional antiterminator [Transcription];
Pssm-ID: 442925 [Multi-domain] Cd Length: 618 Bit Score: 244.38 E-value: 1.29e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 8 ILHRIMTAQYPVKAERLAAEFNVSQRTIRQEVLEANIWLSSKKLPEIRTiRNKGFSLKLENDKQVRLETEIKEVKDgFLN 87
Cdd:COG3711 1 ILKILLKNNNVVTAKELAKKLNVSERTIRYDIKKINEWLKKNGLEIISK-KGIGFRLDIDDEQKEKLLQLLEKSED-PLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 88 RRERIFDLVLAIAYSRNPIHLNKKEEEFQISKSTLDEDMRRLRATLVSYGIEIVSYGKQGLVYKGSERSIRTMIYDFINQ 167
Cdd:COG3711 79 PKERVAYILLRLLLAGDPISLDDLAEELFVSRSTILNDLKKIEKILKKYGLTLERKPNYGIKLEGSELDIRKALAELLSE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 168 NLGMTDFFmnqdaqltpaQKIFFHYFPLAEIKKIEEI---YSNKLLKQEDDIYKKQILLFTLIWIQRIRKHEFISAINWK 244
Cdd:COG3711 159 LLSENDLL----------SLLLLKLIPEEDLELIEEIieeAEKKLGIKLSDSIYINLTDHIAIAIKRIKKGKYIKLDNPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 245 NTEIKDSSFSAFIDYMITEFQLN---NVPQVERNYLRFTIETFNARDISN--SIEWVQAQLLTIQLIQFVENETHIPFHl 319
Cdd:COG3711 229 LWEIKKPKEYEIAKEILKLIEERlgiSLPEDEIGYIALHLLGARLNNDNElsEIITLEITKLIKEIINIIEEELGIDLD- 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 320 KKEALFENLYKHMAALIIRIKHAIQVMNPLKENIRTNYFPIHRAVTHFVPTIEEVIGGKILEDEIAFLVIHFstIASVIK 399
Cdd:COG3711 308 EDSLLYERLITHLKPAINRLKYGIPIRNPLLEEIKEKYPEAFELAKKIAKYLEKELGIEIPEDEIGYLTLHF--GAALER 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 400 RDLNYVYQSVVVCNHGMATGNLLAENLKEKFPQIEITAVLSSKEIELVDKLDVDLIFSTFQLNyrNKPLLVIDPILTETN 479
Cdd:COG3711 386 QKESKKKRVLVVCSSGIGTSRLLKSRLKKLFPEIEIIDVISYRELEEIDLEDYDLIISTVPLE--DKPVIVVSPLLTEED 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 480 ILVIEDFLKRneglqrlkpnshestqlftqiigvmeesggrvdriIYGKLEKLFEINNLeinkreiqpmLKDILTDSNIM 559
Cdd:COG3711 464 IEKIRKFLKQ-----------------------------------IKKKLAKILFELLL----------LLLLLEEKEII 498
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 560 IKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYIVIGKHMALAHARPEDGVNKLGVSVATIEQPIDFGNP 639
Cdd:COG3711 499 ILLLLLLIEEALAADAIEELEEEEIEEELEEIIIIIVIAIPIIIIIIIAIIVLAAEEPGVIKLILVLLLLLILIILLEDD 578
|
650 660 670
....*....|....*....|....*....|....*.
gi 488258440 640 EMDPVKIIFCLAAVDSYSHLNIMKELIELINNEEKL 675
Cdd:COG3711 579 EALLVILLLLLLLIESSLLLLLLLELLLELELELLI 614
|
|
| PtsN |
COG1762 |
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ... |
547-691 |
2.31e-36 |
|
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 441368 [Multi-domain] Cd Length: 150 Bit Score: 133.44 E-value: 2.31e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 547 PMLKDILTDSNIMIKEKAATWEESIERAAKPLVKENIV--EERYVEAMIRAVNEYGPYIviGKHMALAHARPEdGVNKLG 624
Cdd:COG1762 1 MMLSDLLTPELILLDLEASSKEEAIEELAELLAEKGYVldKEEYLEALLEREELGSTGI--GPGIAIPHARPE-GVKKPG 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488258440 625 VSVATIEQPIDFGNPEMDPVKIIFCLAA--VDSYSHLNIMKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:COG1762 78 IAVARLKEPVDFGAMDGEPVDLVFLLAApeDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILELL 146
|
|
| PTS_IIA_fru |
cd00211 |
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ... |
553-691 |
1.54e-33 |
|
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.
Pssm-ID: 238129 [Multi-domain] Cd Length: 136 Bit Score: 124.98 E-value: 1.54e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 553 LTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEyGPYIvIGKHMALAHARPEDgVNKLGVSVATIEQ 632
Cdd:cd00211 1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKE-GSTG-IGNGIAIPHAKSEA-VKKPGIAVLRLKE 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 488258440 633 PIDFGNPEMDPVKIIFCLAAVDSYSHLNIMKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:cd00211 78 PVDFGSLDGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
|
|
| PTS_EIIA_2 |
pfam00359 |
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; |
552-691 |
2.84e-31 |
|
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
Pssm-ID: 459780 [Multi-domain] Cd Length: 139 Bit Score: 118.85 E-value: 2.84e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 552 ILTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYIVIGkhMALAHARPEDgVNKLGVSVATIE 631
Cdd:pfam00359 1 LLDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGIGNG--IAIPHARSEA-VKKPGIAVLTLK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488258440 632 QPIDFGNPEMDPVKIIFCLAAVDSYS-HLNIMKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:pfam00359 78 EPVDFGSEDGKPVKLIFLLAAPDNEAsHLKILSQLARLLQDEEFVEKLLKAKDPEEILEIL 138
|
|
| PRK10372 |
PRK10372 |
PTS ascorbate transporter subunit IIA; |
549-691 |
2.40e-30 |
|
PTS ascorbate transporter subunit IIA;
Pssm-ID: 182417 [Multi-domain] Cd Length: 154 Bit Score: 116.61 E-value: 2.40e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 549 LKDILTDSN-IMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYIVIGKHMALAHARPEDGVNKLGVSV 627
Cdd:PRK10372 3 LRDSLAENKsIRLQAEAETWQEAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLAMPHGRPEEGVKKTGFAL 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488258440 628 ATIEQPIDFGNPEMDPVKIIFCLAAVDSYSHLNI-MKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:PRK10372 83 VTLKKPLEFNHEDNDPVDILITMAAVDANTHQEVgIMQIVNLFEDEANFDRLRACRTEQEVLDLI 147
|
|
| MtlA2 |
COG4668 |
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and ... |
550-691 |
1.02e-23 |
|
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism];
Pssm-ID: 443705 [Multi-domain] Cd Length: 143 Bit Score: 97.54 E-value: 1.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 550 KDILTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYivIGKHMALAHARPE--DGVNKLGVSV 627
Cdd:COG4668 1 MLILTKENIRLNASAANKEEAIRLAGQLLVEAGYVEPEYIDAMLEREAQVSTY--LGNGIAIPHGTNEakDLVLKTGISV 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488258440 628 ATIEQPIDFGNPEmdPVKIIFCLAAVDSySHLNIMKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:COG4668 79 LQFPDGVDWGDGN--TVYLVIGIAAKSD-EHLEILRQLARVLSDEENVEKLAKATDAEEILALL 139
|
|
| cmtB |
PRK09854 |
PTS mannitol transporter subunit IIA; |
549-683 |
5.30e-21 |
|
PTS mannitol transporter subunit IIA;
Pssm-ID: 182114 [Multi-domain] Cd Length: 147 Bit Score: 89.67 E-value: 5.30e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 549 LKDILTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYIVIGKHMALAHARPEDGVNKLGVSVA 628
Cdd:PRK09854 3 LSDYFPESSISVIHSAKDWQEAIDFSMVSLLDKNYISENYIQAIKDSTINNGPYYILAPGVAMPHARPECGALKTGMSLT 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 488258440 629 TIEQPIDFGNPEmDPVKIIFCLAAVDSYSHLNIMKELIELINNEEKLDRLIECTN 683
Cdd:PRK09854 83 LLEQGVYFPGND-EPIKLLIGLSAADADSHIGAIQALSELLCEEEILEQLLTASS 136
|
|
| PTS_IIB_bgl_like |
cd05568 |
PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory ... |
409-490 |
1.69e-20 |
|
PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved in sugar utilization. The domain architecture of the IIB-containing protein includes a region N-terminal to the IIB domain which is homologous to the BglG transcription antiterminator with an RNA-binding domain followed by two homologous domains, PRD1 and PRD2 (PTS Regulation Domains). C-terminal to the IIB domain is a domain similar to the PTS IIA domain. In this system, the BglG-like region and the IIB and IIA-like domains are all expressed together as a single multidomain protein. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include this sensory system with similarity to the bacterial bgl system, chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, and fructose systems.
Pssm-ID: 99910 Cd Length: 85 Bit Score: 86.02 E-value: 1.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 409 VVVCNHGMATGNLLAENLKEKFPQIEITAVLSSKEIELVDKLDVDLIFSTFQLNYRNKPLLVIDPILTETNILVIEDFLK 488
Cdd:cd05568 4 LVVCPSGIGTSRLLKSKLKKLFPEIEIIDVISLRELEEVDLDDYDLIISTVPLEDTDKPVIVVSPILTEEDIKKIRKFIK 83
|
..
gi 488258440 489 RN 490
Cdd:cd05568 84 KL 85
|
|
| PTS_IIB |
cd00133 |
PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the ... |
409-487 |
1.62e-13 |
|
PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system. The PTS is found only in bacteria, where it catalyzes the transport and phosphorylation of numerous monosaccharides, disaccharides, polyols, amino sugars, and other sugar derivatives. The four proteins (domains) forming the PTS phosphorylation cascade (EI, HPr, EIIA, and EIIB), can phosphorylate or interact with numerous non-PTS proteins thereby regulating their activity.
Pssm-ID: 99904 Cd Length: 84 Bit Score: 66.13 E-value: 1.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 409 VVVCNHGMATGNLLAENLKEKFPQIEITAVLSSKEI-ELVDKLDVDLIFSTFQLNYR--NKPLLVIDPILTETNILVIED 485
Cdd:cd00133 3 LVVCGSGIGSSSMLAEKLEKAAKELGIEVKVEAQGLsEVIDLADADLIISTVPLAARflGKPVIVVSPLLNEKDGEKILE 82
|
..
gi 488258440 486 FL 487
Cdd:cd00133 83 KL 84
|
|
| PRK15083 |
PRK15083 |
PTS system mannitol-specific transporter subunit IICBA; Provisional |
522-691 |
5.72e-11 |
|
PTS system mannitol-specific transporter subunit IICBA; Provisional
Pssm-ID: 237905 [Multi-domain] Cd Length: 639 Bit Score: 65.85 E-value: 5.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 522 DRIIYGKL-EKLFEINNLEINKREIQPMLKDI----------LTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVE 590
Cdd:PRK15083 455 DSGLYTSLtERLVAAQRHTENEEKVKDSLKDSfedssanlfkLGAENIFLGLKAATKEEAIRFAGEQLVKGGYVEPEYVD 534
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 591 AMI---RAVNEYgpyivIGKHMALAHARPE--DGVNKLGVSVATIEQPIDFGNPEMDPVKIIFCLAAVDSySHLNIMKEL 665
Cdd:PRK15083 535 AMLdreKLTSTY-----LGESIAVPHGTVEakDRVLKTGVVFCQYPEGVRFGEEEDDIARLVIGIAARNN-EHIQVITSL 608
|
170 180
....*....|....*....|....*.
gi 488258440 666 IELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:PRK15083 609 TNALDDESVIERLAHTTSVDEVLELL 634
|
|
| PRD |
pfam00874 |
PRD domain; The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory ... |
304-392 |
4.79e-09 |
|
PRD domain; The PRD domain (for PTS Regulation Domain), is the phosphorylatable regulatory domain found in bacterial transcriptional antiterminator such as BglG, SacY and LicT, as well as in activators such as MtlR and LevR. The PRD is phosphorylated on one or two conserved histidine residues. PRD-containing proteins are involved in the regulation of catabolic operons in Gram+ and Gram- bacteria and are often characterized by a short N-terminal effector domain that binds to either RNA (CAT-RBD for antiterminators pfam03123) or DNA (for activators), and a duplicated PRD module which is phosphorylated by the sugar phosphotransferase system (PTS) in response to the availability of carbon source. The phosphorylations modify the conformation and stability of the dimeric proteins and thereby the RNA- or DNA-binding activity of the effector domain. The structure of the LicT PRD domains has been solved in both the active (pdb:1h99) and inactive state (pdb:1tlv), revealing massive structural rearrangements upon activation.
Pssm-ID: 459973 [Multi-domain] Cd Length: 90 Bit Score: 53.80 E-value: 4.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 304 QLIQFVENETHIPFhlKKEALFENLYKHMAALIIRIKHAIQVMNPLKENIRTNYFPIHRAVTHFVPTIEEVIGGKILEDE 383
Cdd:pfam00874 2 EIIELIEKKLGITF--DDDILYIRLILHLAFAIERIKEGITIENPLLEEIKEKYPKEFEIAKKILEILEEELGIELPEDE 79
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....*....
gi 488258440 384 IAFLVIHFS 392
Cdd:pfam00874 80 IGYIALHFL 88
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| PRK11109 |
PRK11109 |
fused PTS fructose transporter subunit IIA/HPr protein; |
548-691 |
5.34e-09 |
|
fused PTS fructose transporter subunit IIA/HPr protein;
Pssm-ID: 236849 [Multi-domain] Cd Length: 375 Bit Score: 58.81 E-value: 5.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 548 MLKdiLTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIRAVNEYGPYivIGKHMALAHARPE--DGVNKLGV 625
Cdd:PRK11109 1 MFQ--LSVQDIHLGQQAGNKEEAIRQVAAALTQAGNVAEGYVDGMLAREQQTSTF--LGNGIAIPHGTTDtrDLVLKTGV 76
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488258440 626 SVATIEQPIDFGNPEMDPVKI-IfclaAVDSYSHLNIMKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:PRK11109 77 QVFQFPQGVTWGDGQTAYVAIgI----AAKSDEHLGLLRQLTHVLSDDSVAEQLKSATTAEELRALL 139
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| PRK13779 |
PRK13779 |
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional |
553-691 |
1.70e-05 |
|
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
Pssm-ID: 237502 [Multi-domain] Cd Length: 503 Bit Score: 47.95 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488258440 553 LTDSNIMIKEKAATWEESIERAAKPLVKENIVEERYVEAMIraVNEYGPYIVIGKHMALAHARPEDG--VNKLGVSVATI 630
Cdd:PRK13779 4 LSESNIHLNAQAINKQQAIEMAAAALEQAGNVENGYLQGML--ARELQTSTFLGNGIAIPHGTLDTRhmVKNTGVQIFQF 81
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488258440 631 EQPIDFGnpEMDPVKIIFCLAAvDSYSHLNIMKELIELINNEEKLDRLIECTNVEDFKQLL 691
Cdd:PRK13779 82 PQGIEWG--EGNIAYVVIGIAA-RSDEHLSLLRQLTHVLSDEDTAAKLATLTDVKEFRAIL 139
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