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Conserved domains on  [gi|488277700|ref|WP_002348908|]
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MULTISPECIES: sensor histidine kinase [Enterococcus]

Protein Classification

sensor histidine kinase( domain architecture ID 11459466)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to a signal; may contain an N-terminal HAMP signaling domain

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000155|GO:0004673|GO:0007165|GO:0005524|GO:0000156
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
27-475 8.89e-76

Sensor histidine kinase YesM [Signal transduction mechanisms];


:

Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 244.93  E-value: 8.89e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  27 LLSILLYSQQLLIYQQTIANIQKADAIALKVDQKVLESMWDLISGQVTVDEFNEENILEELRNDIREIKNNTNTLKEIST 106
Cdd:COG2972    7 LLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 107 LDVSLRTIDTLEDYQNELINNILAKDFMDTIEEIINQVDSVTQLLSDILQDFVRVEIDLAS-KKNTTLVRSLILLTIVEL 185
Cdd:COG2972   87 LLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSElFRGLFSLRRLILLIILLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 186 GVLSTIFFYakknrrFLERKVQEPINQLIEMSEQLSSGNLgFRLTLPETLELQTLTASMNKMAEDLNQSLRENALKQYHL 265
Cdd:COG2972  167 LLLALLLSY------LLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 266 AQSEVRVLQAQITPHFIYNSLDAIISLIEQDCFEEALTMTHALSGFFRTSLSKGQDWIPLEKEISHINDYLVILKIRYGH 345
Cdd:COG2972  240 KEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 346 MLDYKIDIPETLFPVSILKMILQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKg 425
Cdd:COG2972  320 RLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSS- 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 488277700 426 idSDFSIGYGLYNVNKRLLLYYGNDQKpITIDSKYREGTTVTLMIPLSPK 475
Cdd:COG2972  399 --KGEGRGIGLRNVRERLKLYYGEEYG-LEIESEPGEGTTVTIRIPLEEE 445
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
27-475 8.89e-76

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 244.93  E-value: 8.89e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  27 LLSILLYSQQLLIYQQTIANIQKADAIALKVDQKVLESMWDLISGQVTVDEFNEENILEELRNDIREIKNNTNTLKEIST 106
Cdd:COG2972    7 LLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 107 LDVSLRTIDTLEDYQNELINNILAKDFMDTIEEIINQVDSVTQLLSDILQDFVRVEIDLAS-KKNTTLVRSLILLTIVEL 185
Cdd:COG2972   87 LLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSElFRGLFSLRRLILLIILLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 186 GVLSTIFFYakknrrFLERKVQEPINQLIEMSEQLSSGNLgFRLTLPETLELQTLTASMNKMAEDLNQSLRENALKQYHL 265
Cdd:COG2972  167 LLLALLLSY------LLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 266 AQSEVRVLQAQITPHFIYNSLDAIISLIEQDCFEEALTMTHALSGFFRTSLSKGQDWIPLEKEISHINDYLVILKIRYGH 345
Cdd:COG2972  240 KEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 346 MLDYKIDIPETLFPVSILKMILQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKg 425
Cdd:COG2972  320 RLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSS- 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 488277700 426 idSDFSIGYGLYNVNKRLLLYYGNDQKpITIDSKYREGTTVTLMIPLSPK 475
Cdd:COG2972  399 --KGEGRGIGLRNVRERLKLYYGEEYG-LEIESEPGEGTTVTIRIPLEEE 445
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 268-347 2.23e-25

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 99.05  E-value: 2.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  268 SEVRVLQAQITPHFIYNSLDAIISLIEQDCfEEALTMTHALSGFFRTSLSKGQDWIPLEKEISHINDYLVILKIRYGHML 347
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDP-EEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-471 6.58e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 81.72  E-value: 6.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 362 ILKMILQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPaEKLAEIRkelakGIDSDFSIGYGLYNVNK 441
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGID-PKVLNIL-----GKKPKEGNGIGLYNVHQ 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 488277700 442 RLLLYYGnDQKPITIDSKYREGTTVTLMIP 471
Cdd:cd16924   75 RLILLFG-EDYGIHIASEPDKGTRITFTIP 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 363-473 7.71e-16

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 73.45  E-value: 7.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700   363 LKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKGIDSDFSI---GYGLYNV 439
Cdd:smart00387   6 LRQVLSNLLDNAI----KYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIggtGLGLSIV 81

                           90       100       110
                   ....*....|....*....|....*....|....
gi 488277700   440 NKRLLLYYGNdqkpITIDSKYREGTTVTLMIPLS 473
Cdd:smart00387  82 KKLVELHGGE----ISVESEPGGGTTFTITLPLE 111
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
175-302 1.46e-05

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 47.54  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 175 RSLILLTIVELGVLSTIFFYAKKNRRFLERKVQEPINQLIEMSEQLSSGNLGFrLTLPETL--ELQTLTASMNKMAEDLN 252
Cdd:PRK10935 145 RKLILLAAISLLGLILILTLVFFTVRFTRRQVVAPLNQLVTASQQIEKGQFDH-IPLDTTLpnELGLLAKAFNQMSSELH 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488277700 253 QSLR--ENALKQYHLAQSEV-RVLQaqitphFIYNSLDAI-ISLIEQDCFEEAL 302
Cdd:PRK10935 224 KLYRslEASVEEKTRKLTQAnRSLE------VLYQCSQALnASQIDVHCFRHIL 271
 
Name Accession Description Interval E-value
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
27-475 8.89e-76

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 244.93  E-value: 8.89e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  27 LLSILLYSQQLLIYQQTIANIQKADAIALKVDQKVLESMWDLISGQVTVDEFNEENILEELRNDIREIKNNTNTLKEIST 106
Cdd:COG2972    7 LLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 107 LDVSLRTIDTLEDYQNELINNILAKDFMDTIEEIINQVDSVTQLLSDILQDFVRVEIDLAS-KKNTTLVRSLILLTIVEL 185
Cdd:COG2972   87 LLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSElFRGLFSLRRLILLIILLL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 186 GVLSTIFFYakknrrFLERKVQEPINQLIEMSEQLSSGNLgFRLTLPETLELQTLTASMNKMAEDLNQSLRENALKQYHL 265
Cdd:COG2972  167 LLLALLLSY------LLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 266 AQSEVRVLQAQITPHFIYNSLDAIISLIEQDCFEEALTMTHALSGFFRTSLSKGQDWIPLEKEISHINDYLVILKIRYGH 345
Cdd:COG2972  240 KEAELKALQAQINPHFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGD 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 346 MLDYKIDIPETLFPVSILKMILQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKg 425
Cdd:COG2972  320 RLEVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSS- 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 488277700 426 idSDFSIGYGLYNVNKRLLLYYGNDQKpITIDSKYREGTTVTLMIPLSPK 475
Cdd:COG2972  399 --KGEGRGIGLRNVRERLKLYYGEEYG-LEIESEPGEGTTVTIRIPLEEE 445
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
173-475 4.88e-52

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 179.68  E-value: 4.88e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 173 LVRSLILLTIVELGVLSTIFFYAKKNRRFLERKVQEPINQLIEMSEQLSSGNLGFRLTLPETLELQTLTASMNKMAEDLN 252
Cdd:COG3275   64 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQ 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 253 QSLRENALKQYHLAQSEVRVLQAQITPHFIYNSLDAIISLIEQDCfEEALTMTHALSGFFRTSLSKG-QDWIPLEKEISH 331
Cdd:COG3275  144 EEELELEELEKELLEAELKALKAQINPHFLFNTLNSIYSLIREDP-EKARELLLKLSDLLRYSLYESdKELVPLEEELEF 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 332 INDYLVILKIRYGHMLDYKIDIPETLFPVSILKMILQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIP 411
Cdd:COG3275  223 LENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQ 302

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488277700 412 AEKLAEirkelakgidsdfSIGYGLYNVNKRLLLYYGNDQKpITIDSKYREGTTVTLMIPLSPK 475
Cdd:COG3275  303 PKKKKK-------------GSGIGLKNVRERLELLYGDKYS-LEIESTDGGGTKVTLKIPLKKE 352
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
 268-347 2.23e-25

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 99.05  E-value: 2.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  268 SEVRVLQAQITPHFIYNSLDAIISLIEQDCfEEALTMTHALSGFFRTSLSKGQDWIPLEKEISHINDYLVILKIRYGHML 347
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDP-EEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-471 6.58e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 81.72  E-value: 6.58e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 362 ILKMILQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPaEKLAEIRkelakGIDSDFSIGYGLYNVNK 441
Cdd:cd16924    1 IPPFTLQPLVENAIQHGLSPLTDKGVVTISALKEDNHVMIEVEDNGRGID-PKVLNIL-----GKKPKEGNGIGLYNVHQ 74

                         90       100       110
                 ....*....|....*....|....*....|
gi 488277700 442 RLLLYYGnDQKPITIDSKYREGTTVTLMIP 471
Cdd:cd16924   75 RLILLFG-EDYGIHIASEPDKGTRITFTIP 103
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 363-473 7.71e-16

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 73.45  E-value: 7.71e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700   363 LKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKGIDSDFSI---GYGLYNV 439
Cdd:smart00387   6 LRQVLSNLLDNAI----KYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIggtGLGLSIV 81

                           90       100       110
                   ....*....|....*....|....*....|....
gi 488277700   440 NKRLLLYYGNdqkpITIDSKYREGTTVTLMIPLS 473
Cdd:smart00387  82 KKLVELHGGE----ISVESEPGGGTTFTITLPLE 111
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 362-471 7.29e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 70.18  E-value: 7.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 362 ILKMILQPLIENAVYHGTKYVRHKGFIRITTCK-IDEMIQFKVIDNGIGIPAEKLAEIRKELAKGidsdfsIGYGLYNVN 440
Cdd:cd16955    1 IPKLMIQPLVENAIVHGIQEKKGKGVVKISVKKqLKNRLHIAVEDNGIGISPKVIERVEQDEMPG------NKIGLLNVH 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 488277700 441 KRLLLYYGNDQKpitIDSKYREGTTVTLMIP 471
Cdd:cd16955   75 QRLKLGYGEGLH---IRSRPDPGTLIAFYIP 102
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 363-474 2.89e-14

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 68.93  E-value: 2.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  363 LKMILQPLIENAVyhgtKYVRHKGFIRITtCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKGIDSDFS-IGYGLYNVNK 441
Cdd:pfam02518   6 LRQVLSNLLDNAL----KHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGgTGLGLSIVRK 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 488277700  442 RLLLYYGNdqkpITIDSKYREGTTVTLMIPLSP 474
Cdd:pfam02518  81 LVELLGGT----ITVESEPGGGTTVTLTLPLAQ 109
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 367-471 1.84e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 66.29  E-value: 1.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 367 LQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELakgIDSDFSIGYGLYNVNKRLLLY 446
Cdd:cd16957    6 LQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTT---VTSEKGTGTALENLNRRLIGL 82

                         90       100
                 ....*....|....*....|....*
gi 488277700 447 YGNdQKPITIDSKYREGTTVTLMIP 471
Cdd:cd16957   83 FGS-EACLHIESEVHGGTEVWFVIP 106
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 363-468 4.91e-13

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 64.93  E-value: 4.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 LKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKGIDSDFSIGY--GLYNVN 440
Cdd:cd00075    1 LEQVLSNLLDNAL----KYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTglGLAIVR 76

                         90       100
                 ....*....|....*....|....*...
gi 488277700 441 KRLLLYYGNdqkpITIDSKYREGTTVTL 468
Cdd:cd00075   77 RIVEAHGGR----ITVESEPGGGTTFTV 100
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
282-474 1.27e-12

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 67.24  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 282 IYNSLDAIISLIEQdcfeeALTMTHALSGFFRTSLskgqDWIPLEKEISHINDYLVILKIRYGHMLDykIDIPETLFPVS 361
Cdd:COG2205   59 IRESAERLLRLIED-----LLDLSRLESGKLSLEL----EPVDLAELLEEAVEELRPLAEEKGIRLE--LDLPPELPLVY 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 362 I----LKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEI--RKELAKGIDSDFSIGYG 435
Cdd:COG2205  128 AdpelLEQVLANLLDNAI----KYSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIfeRFYRGDNSRGEGGTGLG 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 488277700 436 LYNVnKRLL-LYYGNdqkpITIDSKYREGTTVTLMIPLSP 474
Cdd:COG2205  204 LAIV-KRIVeAHGGT----IWVESEPGGGTTFTVTLPLAE 238
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 367-471 4.74e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 62.07  E-value: 4.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 367 LQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEirkelakgIDSDFSIGYGLYNVNKRLLLY 446
Cdd:cd16956    6 LQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDPDTLAR--------ILIRSSNGLGLNLVDKRLRQA 77

                         90       100
                 ....*....|....*....|....*
gi 488277700 447 YGNDQKpITIDSKYREGTTVTLMIP 471
Cdd:cd16956   78 FGNDYG-LDIECAPGEGTRITIRLP 101
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
282-473 2.89e-11

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 64.54  E-value: 2.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 282 IYNSLDAIISLIEQdcfeeALTMTHALSGFFRTSLSKgqdwIPLEKEISHINDYLVILKIRYGhmLDYKIDIPETLFPVS 361
Cdd:COG0642  150 ILRSADRLLRLIND-----LLDLSRLEAGKLELEPEP----VDLAELLEEVVELFRPLAEEKG--IELELDLPDDLPTVR 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 362 I----LKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKGIDSDFSIGY--G 435
Cdd:COG0642  219 GdpdrLRQVLLNLLSNAI----KYTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglG 294

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 488277700 436 LYnVNKRLLLYYGNDqkpITIDSKYREGTTVTLMIPLS 473
Cdd:COG0642  295 LA-IVKRIVELHGGT---IEVESEPGKGTTFTVTLPLA 328
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 261-475 8.67e-11

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 63.71  E-value: 8.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 261 KQYHLAQSEVRVLQAQItpHFIYNSLDAIISLIEQDCFEEALTMTHALSgffrtslSKGQDWIplEKEISHINDYLV--I 338
Cdd:COG3290  181 EELEGVKELAEALRAQR--HDFRNHLHTISGLLQLGEYDEALEYIDEIS-------EELQELI--DSLLSRIGNPVLaaL 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 339 LKIRYGHMLDYKID--------IPETLFPVSILKMILQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGI 410
Cdd:COG3290  250 LLGKAARARERGIDltididsdLPDLPLSDTDLVTILGNLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSGPGI 329

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488277700 411 PAEKLAEIrkeLAKGIDSDFSI--GYGLYNVNKRLLLYYGNdqkpITIDSKYREGTTVTLMIPLSPK 475
Cdd:COG3290  330 PEELLEKI---FERGFSTKLGEgrGLGLALVKQIVEKYGGT----IEVESEEGEGTVFTVRLPKEGE 389
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
350-475 1.34e-08

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 56.87  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 350 KIDIPETLFPVSI----LKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEI-----RK 420
Cdd:COG5002  265 ELDLPEDPLLVLGdpdrLEQVLTNLLDNAI----KYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIferfyRV 340

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488277700 421 ELAKGIDSDfSIGYGLYNVnKRLLLYYGNDqkpITIDSKYREGTTVTLMIPLSPK 475
Cdd:COG5002  341 DKSRSRETG-GTGLGLAIV-KHIVEAHGGR---IWVESEPGKGTTFTITLPLARE 390
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 128-473 6.27e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 51.34  E-value: 6.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 128 ILAKDFMDTIEEIINQVDSVTQLLSDILQDFVRVEIDLASKKNTTLVRSLILLTIVELGVLSTIFFYAKKNRRFLERKVQ 207
Cdd:COG4191   48 ALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELR 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 208 EPINQLIEmSEQLSSgnLGfrltlpetlelqTLTASMnkmAEDLNQSLreNALKQYhlAQSEVRVLQAQITPHFIYNSLD 287
Cdd:COG4191  128 ELQEQLVQ-SEKLAA--LG------------ELAAGI---AHEINNPL--AAILGN--AELLRRRLEDEPDPEELREALE 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 288 AIISLIEQdcfeeALTMTHALSGFFRTSlskgqdwiPLEKEISHINDY----LVILKIRYGHM-LDYKIDIPETLFPVSI 362
Cdd:COG4191  186 RILEGAER-----AAEIVRSLRAFSRRD--------EEEREPVDLNELideaLELLRPRLKARgIEVELDLPPDLPPVLG 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 ----LKMILQPLIENAVY--HGtkyvRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEI------RKELAKGidsdf 430
Cdd:COG4191  253 dpgqLEQVLLNLLINAIDamEE----GEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIfepfftTKPVGKG----- 323

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 488277700 431 sIGYGLYNVnkrlllyYGNDQK---PITIDSKYREGTTVTLMIPLS 473
Cdd:COG4191  324 -TGLGLSIS-------YGIVEKhggRIEVESEPGGGTTFTITLPLA 361
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 177-476 8.42e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 51.12  E-value: 8.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 177 LILLTIVELGVLSTIFFyakknRRFLERKVQEPINQLIEMSEQLSSGNLGFRLTLPETLELQTLTASMNKMAEDLNQS-- 254
Cdd:COG5000    9 LLLLLIALLLLLLALWL-----ALLLARRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEQre 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 255 --------------------------------------------------------------------LRENALKQYHLA 266
Cdd:COG5000   84 eleerrryletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellreaLERGWQEEIELT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 267 QSEVRVLQAQITP---------------------------------HFIYNSLDAIISLIE-----------------QD 296
Cdd:COG5000  164 RDGRRTLLVRASPlrddgyvivfdditellraerlaawgelarriaHEIKNPLTPIQLSAErlrrkladkleedredlER 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 297 CFEEALTMTHALSGF---FRtSLSKGQdwiPLEKEISHINDYL--VILKIRYGHM---LDYKIDIPETLFPVSI----LK 364
Cdd:COG5000  244 ALDTIIRQVDRLKRIvdeFL-DFARLP---EPQLEPVDLNELLreVLALYEPALKekdIRLELDLDPDLPEVLAdrdqLE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 365 MILQPLIENAVYHgtkyVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEI------RKElaKGidsdfsIGYGLYN 438
Cdd:COG5000  320 QVLINLLKNAIEA----IEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIfepfftTKP--KG------TGLGLAI 387

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 488277700 439 VNKRLLLYYGNdqkpITIDSKYREGTTVTLMIPLSPKT 476
Cdd:COG5000  388 VKKIVEEHGGT----IELESRPGGGTTFTIRLPLAEEA 421
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-471 9.31e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 47.28  E-value: 9.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 LKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEI----------RKELAkgidsdfSI 432
Cdd:cd16948    6 LSFIIGQIVSNAL----KYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVfdkgftgengRNFQE-------ST 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 488277700 433 GYGLYNVNK---RLLLyygndqkPITIDSKYREGTTVTLMIP 471
Cdd:cd16948   75 GMGLYLVKKlcdKLGH-------KIDVESEVGEGTTFTITFP 109
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 363-473 1.69e-06

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 50.13  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 LKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEI------RKELAKGIdsdfsigyGL 436
Cdd:COG5808  352 IKQVLLNLIKNAI----EAMKEGGKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIfepfvtTKEGGTGL--------GL 419

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 488277700 437 YnVNKRLLLYYGNDqkpITIDSKYREGTTVTLMIPLS 473
Cdd:COG5808  420 S-VCKRIVEMHGGE---IDIESEEGKGTTFTIRLPLK 452
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
1-257 1.89e-06

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 50.40  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700   1 MTKNLSIKQIFAQANKAMLLFAVIPLLLSILLYSQQLLIYQQTIANIQKADAIALKVDQKVLESMWDLISGQVTVDEFNE 80
Cdd:COG0840    7 LLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  81 ENILEELRNDIREIKNNTNTLKEISTLDVSLRTIDTLEDYQNELINNILAKDFMDTIEEIINQVDSVTQLLSDILQDFVR 160
Cdd:COG0840   87 ALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAAL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 161 VEIDLASKKNTTLVRSLILLTIVELGVLSTIFFYakknrrFLERKVQEPINQLIEMSEQLSSGNLGFRLTLPETLELQTL 240
Cdd:COG0840  167 LEAAALALAAAALALALLAAALLALVALAIILAL------LLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQL 240

                        250
                 ....*....|....*..
gi 488277700 241 TASMNKMAEDLNQSLRE 257
Cdd:COG0840  241 ADAFNRMIENLRELVGQ 257
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
204-256 2.22e-06

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 44.55  E-value: 2.22e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 488277700   204 RKVQEPINQLIEMSEQLSSGNLGFRLTLPETLELQTLTASMNKMAEDLNQSLR 256
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 363-474 3.91e-06

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 49.40  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 LKMILQPLIENAVyhgtKYVR--HKGFIRITTCKIDEMIQFKVIDNGIGIP---AEKLAEIRKELAKgiDSDFS-IGYGL 436
Cdd:COG4251  395 LRQVFQNLISNAI----KYSRpgEPPRIEIGAEREGGEWVFSVRDNGIGIDpeyAEKIFEIFQRLHS--RDEYEgTGIGL 468

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 488277700 437 YNVnKRLLLYYGNDqkpITIDSKYREGTTVTLMIPLSP 474
Cdd:COG4251  469 AIV-KKIVERHGGR---IWVESEPGEGATFYFTLPKAP 502
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 363-472 1.25e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 44.02  E-value: 1.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 LKMILQPLIENAVyhgtKYVrHKGFIRITTCKIDE-----MIQFKVIDNGIGIPAEKLAEIRKELAKgIDSDFSIGY--- 434
Cdd:cd16922    1 LRQILLNLLGNAI----KFT-EEGEVTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQ-ADSSTTRKYggt 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488277700 435 --GLYnVNKRLLLYYGNDqkpITIDSKYREGTTVTLMIPL 472
Cdd:cd16922   75 glGLA-ISKKLVELMGGD---ISVESEPGQGSTFTFTLPL 110
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
175-302 1.46e-05

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 47.54  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 175 RSLILLTIVELGVLSTIFFYAKKNRRFLERKVQEPINQLIEMSEQLSSGNLGFrLTLPETL--ELQTLTASMNKMAEDLN 252
Cdd:PRK10935 145 RKLILLAAISLLGLILILTLVFFTVRFTRRQVVAPLNQLVTASQQIEKGQFDH-IPLDTTLpnELGLLAKAFNQMSSELH 223

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488277700 253 QSLR--ENALKQYHLAQSEV-RVLQaqitphFIYNSLDAI-ISLIEQDCFEEAL 302
Cdd:PRK10935 224 KLYRslEASVEEKTRKLTQAnRSLE------VLYQCSQALnASQIDVHCFRHIL 271
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 209-251 1.47e-05

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 42.05  E-value: 1.47e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 488277700 209 PINQLIEMSEQLSSGNLGFRLTLPETLELQTLTASMNKMAEDL 251
Cdd:cd06225    3 PLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
HAMP pfam00672
HAMP domain;
201-253 2.55e-05

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 41.46  E-value: 2.55e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488277700  201 FLERKVQEPINQLIEMSEQLSSGNLGFRLTLPETLELQTLTASMNKMAEDLNQ 253
Cdd:pfam00672   1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-448 5.98e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 42.05  E-value: 5.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 LKMILQPLIENAVYHGtkyvrhKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKELAKGIDSDFSIGYGL-YNVNK 441
Cdd:cd16950    1 LKRVLSNLVDNALRYG------GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLgLAIVQ 74


                 ....*..
gi 488277700 442 RLLLYYG 448
Cdd:cd16950   75 RISDAHG 81
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 363-472 7.44e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 45.32  E-value: 7.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 LKMILQPLIENAVyhgtKYVrHKGFIRIT-TCKIDEMIQFKVIDNGIGIPAEKLAEI-----RKELAKGIDSDFSIGYGL 436
Cdd:PRK11091 399 LRQILWNLISNAV----KFT-QQGGVTVRvRYEEGDMLTFEVEDSGIGIPEDELDKIfamyyQVKDSHGGKPATGTGIGL 473

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488277700 437 yNVNKRLLLYYGNDqkpITIDSKYREGTTVTLMIPL 472
Cdd:PRK11091 474 -AVSKRLAQAMGGD---ITVTSEEGKGSCFTLTIHA 505
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 363-471 7.91e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 41.93  E-value: 7.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 363 LKMILQPLIENAVyhgtKYvRHKG---FIRITTCKIDEMIQFKVIDNGIGIP---AEKLAEIRKELAKGIDSDFSiGYGL 436
Cdd:cd16921    1 LGQVLTNLLGNAI----KF-RRPRrppRIEVGAEDVGEEWTFYVRDNGIGIDpeyAEKVFGIFQRLHSREEYEGT-GVGL 74

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 488277700 437 YNVNKRLLLYYGNdqkpITIDSKYREGTTVTLMIP 471
Cdd:cd16921   75 AIVRKIIERHGGR----IWLESEPGEGTTFYFTLP 105
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 386-475 1.14e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 44.58  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 386 GFIRI-TTCKIDEMIQFKVIDNGIGIPAEKLAEI------RKElaKGidsdfsIGYGLYNVNKRLLLYYGNdqkpITIDS 458
Cdd:COG5809  399 GNITIeTKAEDDDKVVISVTDEGCGIPEERLKKLgepfytTKE--KG------TGLGLMVSYKIIEEHGGK----ITVES 466

                         90
                 ....*....|....*..
gi 488277700 459 KYREGTTVTLMIPLSPK 475
Cdd:COG5809  467 EVGKGTTFSITLPIKLS 483
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
370-472 1.74e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 41.44  E-value: 1.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 370 LIENAVYHGTKYvRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEirkelakGIDSDFSIGYGLYNVnKRLLlyygn 449
Cdd:COG2172   42 AVTNAVRHAYGG-DPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPD-------PYSTLAEGGRGLFLI-RRLM----- 107

                         90       100
                 ....*....|....*....|...
gi 488277700 450 DQkpITIDSKyREGTTVTLMIPL 472
Cdd:COG2172  108 DE--VEYESD-PGGTTVRLVKRL 127
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 105-429 1.82e-04

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 43.72  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 105 STLDVSLRTIDTLEDYQNELINNILAKDFMDTIEEIINQVDSVTQLLSDILQDFVRVEIDLASKKNTTLVRSLILLTIVE 184
Cdd:COG3850   46 LSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 185 LGVLSTIFFYakknrRFLERKVQEPINQLIEMSEQLSSGNLGFRLTLPETLELQTLTASMNKMAEDLNQS---LRENALK 261
Cdd:COG3850  126 LALLLALLLA-----YLLRRRIVRPLRRLTQAAERIARGDFDARVPVSGRDELGTLARAFNRMADELQELyaeLEEEEEL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 262 QYHLAQSEVRVLQAQITPHFIYNSLDAIISLIEQDCFEEALTMTHALSGFFRTSLSKGQDWIPLEKEISHINDYLVILKI 341
Cdd:COG3850  201 EAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLASALLL 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 342 RYGHMLDYKIDIPETLFPVSILKMILQPLIENAVYHGTKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEIRKE 421
Cdd:COG3850  281 LELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAGA 360


                 ....*...
gi 488277700 422 LAKGIDSD 429
Cdd:COG3850  361 ALAAAAAA 368
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
1-296 3.41e-04

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 43.18  E-value: 3.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700   1 MTKNLSIKQIFAQANKAMLLFAVIPLLLSILLYSQQLLIYQQTIANIQKADAIALKVDQKVLESMWDLISGQVTVDEFNE 80
Cdd:COG2770   36 LLALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  81 ENILEELRNDIREIKNNTNTLKEISTLDVSLRTIDTLEDYQNELINNILAKDFMDTIEEIINQVDSVTQLLSDILQDFVR 160
Cdd:COG2770  116 AALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLL 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 161 VEIDLASKKNTTLVRSLILLTIVELGVLSTIFFYAkknrrFLERKVQEPINQLIEMSEQLSSGNLGFRLTLPETLELQTL 240
Cdd:COG2770  196 GGLLLVVLLEAALAALLLLLLLALLALLLALLLAL-----LLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKDEIGEL 270

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488277700 241 TASMNKMAEDLNQSLRENALKQYHLAQSEVRVLQAQITPHFIYNSLDAIISLIEQD 296
Cdd:COG2770  271 ARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAA 326
PTZ00438 PTZ00438
gamete antigen 27/25-like protein; Provisional
 76-213 3.83e-04

gamete antigen 27/25-like protein; Provisional


Pssm-ID: 185618  Cd Length: 374  Bit Score: 42.74  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700  76 DEFNEENILEELRNDIREIKNNTNTLKEI-STLDvSLRTI--------DTLEDYQNELIN-------NILAKDFMDTIEE 139
Cdd:PTZ00438 152 NELAGEYIIEEVDDDVAILNENINSIDELeDPLD-SYKSIflifftefDTTETYLNKIINcatdeekNELLDDHIGILKE 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 140 IINQV-------------DSVTQLLSDILQDFVRVeiDLASKKNTTLVRSLILLtivELGVLSTIFFYAKKNRRFLERKv 206
Cdd:PTZ00438 231 MYENCkkhdnfrlpfeirDSMALRISDRLRDFCFS--DPLTDSNMLALKSIFSI---ELEVFEGIFYYIEHKNTYREKK- 304


                 ....*..
gi 488277700 207 qEPINQL 213
Cdd:PTZ00438 305 -EVINDL 310
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
267-475 7.33e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 41.14  E-value: 7.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 267 QSEVRVLQAQITPHFIYNSLDAIISLIEqdcfeEALTMTHALSGFFRTSLSKGQDWIP-LEKEISHINDylvilkiRYGH 345
Cdd:COG4585   75 QLEAARRLLDADPEAAREELEEIRELAR-----EALAELRRLVRGLRPPALDDLGLAAaLEELAERLLR-------AAGI 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 346 MLDYKIDIPETLFPVSI---LKMILQPLIENAVYHGTkyVRHkgfIRITTCKIDEMIQFKVIDNGIGIPAEKLAeirkel 422
Cdd:COG4585  143 RVELDVDGDPDRLPPEVelaLYRIVQEALTNALKHAG--ATR---VTVTLEVDDGELTLTVRDDGVGFDPEAAP------ 211

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488277700 423 akgidsdfSIGYGLYNVNKRLLLYYGNdqkpITIDSKYREGTTVTLMIPLSPK 475
Cdd:COG4585  212 --------GGGLGLRGMRERAEALGGT----LTIGSAPGGGTRVRATLPLAAA 252
PRK10490 PRK10490
sensor protein KdpD; Provisional
 345-425 1.68e-03

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 41.17  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 345 HMLDY-------KIDIPETLFPV----SILKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAE 413
Cdd:PRK10490 750 QMLEPglsghpiNLSLPEPLTLIhvdgPLFERVLINLLENAV----KYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPG 825

                         90
                 ....*....|..
gi 488277700 414 KLAEIRKELAKG 425
Cdd:PRK10490 826 QEQLIFDKFARG 837
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 361-472 3.06e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 37.40  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488277700 361 SILKMILQPLIENAVyhgtKYVRHKGFIRITTCKIDEMIQFKVIDNGIGIPAEKLAEI------RKELAKGIDSDFSIGY 434
Cdd:cd16943    2 SQLNQVLLNLLVNAA----QAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIfdpfftTKPVGEGTGLGLSLSY 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 488277700 435 GLynVNKRlllyygndQKPITIDSKYREGTTVTLMIPL 472
Cdd:cd16943   78 RI--IQKH--------GGTIRVASVPGGGTRFTIILPI 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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