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Conserved domains on  [gi|488283537|ref|WP_002354745|]
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MULTISPECIES: NusG domain II-containing protein [Bacteria]

Protein Classification

NusG domain II-containing protein( domain architecture ID 10009210)

NusG domain II-containing protein may have a role in a transcription/translation regulating function; similar to Listeria innocua Lin0431 protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5341 COG5341
Uncharacterized conserved protein [Function unknown];
12-140 4.49e-42

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 444125  Cd Length: 126  Bit Score: 135.76  E-value: 4.49e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537  12 LKTWDVIIIAILVLGSFLPLVVFAMQNRGQEAATyqAVLKVDNKVIKVFDLKKDGPHYTYKYEAKDGdYNLIEVDGDRIR 91
Cdd:COG5341    2 MKKGDIILILLLLALSVLSFLVFWLAGNGGGGKV--AVIRVDGKVVKEIPLDDVKEDRTIEVPGPLG-TNIIEIKDGRVR 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 488283537  92 VKEANCADLVDVRRGWISKPGETpIACLPHNLFITVEASDGSEDGSLIY 140
Cdd:COG5341   79 VKEADCPDQICVKTGWISRPGET-IVCLPNKVVIEIEGEDEDEIDAISY 126
 
Name Accession Description Interval E-value
COG5341 COG5341
Uncharacterized conserved protein [Function unknown];
12-140 4.49e-42

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 444125  Cd Length: 126  Bit Score: 135.76  E-value: 4.49e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537  12 LKTWDVIIIAILVLGSFLPLVVFAMQNRGQEAATyqAVLKVDNKVIKVFDLKKDGPHYTYKYEAKDGdYNLIEVDGDRIR 91
Cdd:COG5341    2 MKKGDIILILLLLALSVLSFLVFWLAGNGGGGKV--AVIRVDGKVVKEIPLDDVKEDRTIEVPGPLG-TNIIEIKDGRVR 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 488283537  92 VKEANCADLVDVRRGWISKPGETpIACLPHNLFITVEASDGSEDGSLIY 140
Cdd:COG5341   79 VKEADCPDQICVKTGWISRPGET-IVCLPNKVVIEIEGEDEDEIDAISY 126
NusG_II pfam07009
NusG domain II; This domain is found in some NusG proteins where it forms domain II. However ...
 19-131 3.30e-34

NusG domain II; This domain is found in some NusG proteins where it forms domain II. However most NusG proteins are missing this domain. In other cases this domain is found in isolation. The function of this domain is unknown.


Pssm-ID: 462066  Cd Length: 107  Bit Score: 114.93  E-value: 3.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537   19 IIAILVLGSFLPLVVFAMQNRGQEaatyQAVLKVDNKVIKVFDLKKDGPHYTYKYEAKDGdYNLIEVDGDRIRVKEANCA 98
Cdd:pfam07009   1 LIAALLILSFLSLFLLLGSSKGGK----YAVITVDGKVVKTIPLSKVDEDYTIEIKGEGG-YNTIEIKDGKVRVTEADCP 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 488283537   99 DLVDVRRGWISKPGETpIACLPHNLFITVEASD 131
Cdd:pfam07009  76 DQICVKTGWISKPGQT-IVCLPNKVVIEIEGSE 107
Lin0431_like cd09911
Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) ...
 47-131 4.08e-30

Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); This family contains domains homologous to Listeria innocua Lin0431, a protein that is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (domain II, DII). Lin0431 and Aquifex aeolicus NusG DII (AaeNusG DII ) have similar structure and similar basic charged surface distributions that may bind negatively charged nucleic acids and/or another anionic binding partner, suggesting a possible role in transcription/translation regulating functions. Despite these two domains having low sequence similarity, the NusG DII and DUF1312 domain families may have diverged from common evolutionary ancestral proteins, and may have similar biochemical functions.


Pssm-ID: 197365  Cd Length: 82  Bit Score: 103.70  E-value: 4.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537  47 QAVLKVDNKVIKVFDLkkDGPHYTYKYEAKdGDYNLIEVDGDRIRVKEANCADLVDVRRGWISKPGETpIACLPHNLFIT 126
Cdd:cd09911    2 YAVITVDGKVYKTYPL--DEKDETITIKTG-GGYNIIEIKDGKVRMIEADCPDQICVKTGAISKPGQT-IVCLPHKLVIE 77


                 ....*
gi 488283537 127 VEASD 131
Cdd:cd09911   78 IEGGE 82
 
Name Accession Description Interval E-value
COG5341 COG5341
Uncharacterized conserved protein [Function unknown];
12-140 4.49e-42

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 444125  Cd Length: 126  Bit Score: 135.76  E-value: 4.49e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537  12 LKTWDVIIIAILVLGSFLPLVVFAMQNRGQEAATyqAVLKVDNKVIKVFDLKKDGPHYTYKYEAKDGdYNLIEVDGDRIR 91
Cdd:COG5341    2 MKKGDIILILLLLALSVLSFLVFWLAGNGGGGKV--AVIRVDGKVVKEIPLDDVKEDRTIEVPGPLG-TNIIEIKDGRVR 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 488283537  92 VKEANCADLVDVRRGWISKPGETpIACLPHNLFITVEASDGSEDGSLIY 140
Cdd:COG5341   79 VKEADCPDQICVKTGWISRPGET-IVCLPNKVVIEIEGEDEDEIDAISY 126
NusG_II pfam07009
NusG domain II; This domain is found in some NusG proteins where it forms domain II. However ...
 19-131 3.30e-34

NusG domain II; This domain is found in some NusG proteins where it forms domain II. However most NusG proteins are missing this domain. In other cases this domain is found in isolation. The function of this domain is unknown.


Pssm-ID: 462066  Cd Length: 107  Bit Score: 114.93  E-value: 3.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537   19 IIAILVLGSFLPLVVFAMQNRGQEaatyQAVLKVDNKVIKVFDLKKDGPHYTYKYEAKDGdYNLIEVDGDRIRVKEANCA 98
Cdd:pfam07009   1 LIAALLILSFLSLFLLLGSSKGGK----YAVITVDGKVVKTIPLSKVDEDYTIEIKGEGG-YNTIEIKDGKVRVTEADCP 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 488283537   99 DLVDVRRGWISKPGETpIACLPHNLFITVEASD 131
Cdd:pfam07009  76 DQICVKTGWISKPGQT-IVCLPNKVVIEIEGSE 107
Lin0431_like cd09911
Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) ...
 47-131 4.08e-30

Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); This family contains domains homologous to Listeria innocua Lin0431, a protein that is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (domain II, DII). Lin0431 and Aquifex aeolicus NusG DII (AaeNusG DII ) have similar structure and similar basic charged surface distributions that may bind negatively charged nucleic acids and/or another anionic binding partner, suggesting a possible role in transcription/translation regulating functions. Despite these two domains having low sequence similarity, the NusG DII and DUF1312 domain families may have diverged from common evolutionary ancestral proteins, and may have similar biochemical functions.


Pssm-ID: 197365  Cd Length: 82  Bit Score: 103.70  E-value: 4.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537  47 QAVLKVDNKVIKVFDLkkDGPHYTYKYEAKdGDYNLIEVDGDRIRVKEANCADLVDVRRGWISKPGETpIACLPHNLFIT 126
Cdd:cd09911    2 YAVITVDGKVYKTYPL--DEKDETITIKTG-GGYNIIEIKDGKVRMIEADCPDQICVKTGAISKPGQT-IVCLPHKLVIE 77


                 ....*
gi 488283537 127 VEASD 131
Cdd:cd09911   78 IEGGE 82
DUF1312 cd09846
N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; ...
 47-128 2.46e-24

N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Domains of Unknown Function 1312 (DUF1312) are represented in at least 71 bacterial species with no functional annotation. Included in this family are N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431, having similar structure and surface features that appear to be conserved across these domain families, suggesting similar function. NusG contains NGN at the N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at the C-terminus in bacteria and archaea, and this insert (often known as Domain II) is found in several bacteria. Lin0431 is similar to NGN-insert but does ot contain the disulphite bridge


Pssm-ID: 197363  Cd Length: 81  Bit Score: 89.23  E-value: 2.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537  47 QAVLKVDNKVIKVFDLKKDGPHYTYKYEAKDGdYNLIEVDGDRIRVKEANCADLVDVRRGWISKPGETpIACLPHNLFIT 126
Cdd:cd09846    1 VAVIEVDGKVVRRIDLDGVGKPYTFSIEGEGY-TNIIEVEDGRVRVKESDCPDKICVKTGWISKPGQT-IVCLPNRVIIK 78


                 ..
gi 488283537 127 VE 128
Cdd:cd09846   79 IE 80
NGN-insert_like cd09910
NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) ...
 48-130 1.13e-09

NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); This family contains a unique insert (domain II, DII) found between the highly conserved N-terminal domain (NGN, domain I, D1) and C-terminal Kyrpides Ouzounis and Woese domain (KOW, domain III, DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN) proteins in bacteria such as Aquifex aeolicus NusG (AaeNusG). NusG was originally discovered as having an N-dependent antitermination enhancing activity in Escherichia coli, and has since been shown to have a variety of functions such as being involved in RNA polymerase elongation and Rho-termination. Orthologs of NusG gene exist in bacteria, but their functions and requirements are diverse. The function of DII is as yet unknown, and belongs to Domains of Unknown Function 1312 (DUF1312).


Pssm-ID: 197364  Cd Length: 80  Bit Score: 51.47  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283537  48 AVLKVDNKVIKVFDLKKDGphyTYKYEAKDGDyNLIEVDGDRIRVKEANCADLVDVRRGWISKPGEtPIACLPHNLFITV 127
Cdd:cd09910    3 VVIRAGGKVIYELDLSQDR---TIEVEGPLGP-TTIEIKDGKARVVSSPCPNKYCVRQGWISRAGQ-WIVCLPNQVSVEI 77


                 ...
gi 488283537 128 EAS 130
Cdd:cd09910   78 EGR 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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