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Conserved domains on  [gi|488283617|ref|WP_002354825|]
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MULTISPECIES: methionine ABC transporter permease [Enterococcus]

Protein Classification

methionine ABC transporter permease( domain architecture ID 10005172)

methionine ABC transporter permease is the transmembrane (TM) subunit of the ABC transporter complex, such as MetNPQ, that is involved in methionine import, and is responsible for the translocation of the substrate across the membrane

EC:  7.4.2.11
Gene Ontology:  GO:0033232|GO:0048473|GO:0042626
PubMed:  22095702|11421270|25750732|24638992
TCDB:  3.A.1.24

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 3-222 3.20e-64

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 441614  Cd Length: 220  Bit Score: 198.36  E-value: 3.20e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617   3 FSETFAEYWPSMLIGLKETGIMMSISMAICLLVGLPLGLGLFLANPKVKGHQPWLYWVLNFIVTVIRSFPYLLFVIALIP 82
Cdd:COG2011    1 MLTMWSELWPLLLQATGETLYMVGVSTLIAVLLGLPLGVLLVLTRPGGLLPNPVLYRVLGVIVNIFRSIPFIILLVALIP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617  83 VTRSVLGKAFGPIPSSVPLSIVAIAIFARLVEQVLLDVPEEIYFLANSLGTSKVQYIWHFLLVEARSGLVLAYTTTTVSM 162
Cdd:COG2011   81 LTRLIVGTSIGTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617 163 VSYSTVMGVVGGGGIGDFAVRVGYQRYEYGIMYVAIVIMIALVFILQMLGNFIAQKLDKR 222
Cdd:COG2011  161 IGYSAMAGAVGGGGLGDLAIRYGYQRFDTDVMLVTVVILIVLVQIIQFLGDRLARRLDHR 220
 
Name Accession Description Interval E-value
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 3-222 3.20e-64

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 198.36  E-value: 3.20e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617   3 FSETFAEYWPSMLIGLKETGIMMSISMAICLLVGLPLGLGLFLANPKVKGHQPWLYWVLNFIVTVIRSFPYLLFVIALIP 82
Cdd:COG2011    1 MLTMWSELWPLLLQATGETLYMVGVSTLIAVLLGLPLGVLLVLTRPGGLLPNPVLYRVLGVIVNIFRSIPFIILLVALIP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617  83 VTRSVLGKAFGPIPSSVPLSIVAIAIFARLVEQVLLDVPEEIYFLANSLGTSKVQYIWHFLLVEARSGLVLAYTTTTVSM 162
Cdd:COG2011   81 LTRLIVGTSIGTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617 163 VSYSTVMGVVGGGGIGDFAVRVGYQRYEYGIMYVAIVIMIALVFILQMLGNFIAQKLDKR 222
Cdd:COG2011  161 IGYSAMAGAVGGGGLGDLAIRYGYQRFDTDVMLVTVVILIVLVQIIQFLGDRLARRLDHR 220
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
54-222 5.25e-20

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 84.40  E-value: 5.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617  54 QPWLYWVLNFIVTVIRSFPYLLFVIALIPVTRSVLGKAFGPIPSSVPLSIVAIAIFARLVEQVLLDVPEEIYFLANSLGT 133
Cdd:PRK10782  49 NAKLYRTLSALVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617 134 SKVQYIWHFLLVEARSGLVLAYTTTTVSMVSYSTVMGVVGGGGIGDFAVRVGYQRYEYGIMYVAIVIMIALVFILQMLGN 213
Cdd:PRK10782 129 TPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGD 208


                 ....*....
gi 488283617 214 FIAQKLDKR 222
Cdd:PRK10782 209 RIVRAVTHK 217
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 53-141 1.73e-04

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 41.37  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617   53 HQPWLYWVLNFIVTVIRSFPYLlfVIALIPVTrsVLGkaFGPIPSSVPLSIVAIAIFARLVEQVLLDVPEEIYFLANSLG 132
Cdd:TIGR01097  91 PSPWLYGLARLLLNFLRAIPEL--VWALIFVA--AVG--LGPFAGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATG 164


                  ....*....
gi 488283617  133 TSKVQYIWH 141
Cdd:TIGR01097 165 ASKLQVIRY 173
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 55-208 3.40e-03

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 37.26  E-value: 3.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617  55 PWLYWVLNFIVTVIRSFPYLLFVIALIPVTRSVLGKAFGPIPSSVPLSIVAIAIFA---RLVEQVLLDVPEEIYFLANSL 131
Cdd:cd06261   31 GKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILALLLIAPfarLIRRAALESIPKDLVEAARAL 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488283617 132 GTSKVQYIWHFLLVEARSGLVLAYTTTTVSMVSYSTVMGVVGGGGIGDFAVRVgYQRYEYGIMYVAIVIMIALVFIL 208
Cdd:cd06261  111 GASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGL-LLIFAILFPGDLGVAAAVALILL 186
 
Name Accession Description Interval E-value
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 3-222 3.20e-64

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 198.36  E-value: 3.20e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617   3 FSETFAEYWPSMLIGLKETGIMMSISMAICLLVGLPLGLGLFLANPKVKGHQPWLYWVLNFIVTVIRSFPYLLFVIALIP 82
Cdd:COG2011    1 MLTMWSELWPLLLQATGETLYMVGVSTLIAVLLGLPLGVLLVLTRPGGLLPNPVLYRVLGVIVNIFRSIPFIILLVALIP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617  83 VTRSVLGKAFGPIPSSVPLSIVAIAIFARLVEQVLLDVPEEIYFLANSLGTSKVQYIWHFLLVEARSGLVLAYTTTTVSM 162
Cdd:COG2011   81 LTRLIVGTSIGTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLILGLTVTLISL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617 163 VSYSTVMGVVGGGGIGDFAVRVGYQRYEYGIMYVAIVIMIALVFILQMLGNFIAQKLDKR 222
Cdd:COG2011  161 IGYSAMAGAVGGGGLGDLAIRYGYQRFDTDVMLVTVVILIVLVQIIQFLGDRLARRLDHR 220
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
54-222 5.25e-20

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 84.40  E-value: 5.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617  54 QPWLYWVLNFIVTVIRSFPYLLFVIALIPVTRSVLGKAFGPIPSSVPLSIVAIAIFARLVEQVLLDVPEEIYFLANSLGT 133
Cdd:PRK10782  49 NAKLYRTLSALVNIFRSIPFIILLVWMIPFTRVIVGTSIGLQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617 134 SKVQYIWHFLLVEARSGLVLAYTTTTVSMVSYSTVMGVVGGGGIGDFAVRVGYQRYEYGIMYVAIVIMIALVFILQMLGN 213
Cdd:PRK10782 129 TPMQIVRKVLLPEALPGLVNAATITLITLVGYSAMGGAVGAGGLGQIGYQYGYIGYNATVMNTVLVLLVILVYLIQFAGD 208


                 ....*....
gi 488283617 214 FIAQKLDKR 222
Cdd:PRK10782 209 RIVRAVTHK 217
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 53-141 1.73e-04

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 41.37  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617   53 HQPWLYWVLNFIVTVIRSFPYLlfVIALIPVTrsVLGkaFGPIPSSVPLSIVAIAIFARLVEQVLLDVPEEIYFLANSLG 132
Cdd:TIGR01097  91 PSPWLYGLARLLLNFLRAIPEL--VWALIFVA--AVG--LGPFAGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATG 164


                  ....*....
gi 488283617  133 TSKVQYIWH 141
Cdd:TIGR01097 165 ASKLQVIRY 173
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 55-208 3.40e-03

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 37.26  E-value: 3.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488283617  55 PWLYWVLNFIVTVIRSFPYLLFVIALIPVTRSVLGKAFGPIPSSVPLSIVAIAIFA---RLVEQVLLDVPEEIYFLANSL 131
Cdd:cd06261   31 GKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILALLLIAPfarLIRRAALESIPKDLVEAARAL 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488283617 132 GTSKVQYIWHFLLVEARSGLVLAYTTTTVSMVSYSTVMGVVGGGGIGDFAVRVgYQRYEYGIMYVAIVIMIALVFIL 208
Cdd:cd06261  111 GASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGL-LLIFAILFPGDLGVAAAVALILL 186
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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