MULTISPECIES: ribosome small subunit-dependent GTPase A [Enterococcus]
Protein Classification
ribosome small subunit-dependent GTPase A( domain architecture ID 11478067)
ribosome small subunit-dependent GTPase A is a late-stage ribosome biogenesis factor involved in 30S subunit maturation
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| PRK00098 | PRK00098 | GTPase RsgA; Reviewed |
4-291 | 2.33e-140 | |||||
GTPase RsgA; Reviewed : Pssm-ID: 234631 [Multi-domain] Cd Length: 298 Bit Score: 397.65 E-value: 2.33e-140
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| Name | Accession | Description | Interval | E-value | |||||
| PRK00098 | PRK00098 | GTPase RsgA; Reviewed |
4-291 | 2.33e-140 | |||||
GTPase RsgA; Reviewed Pssm-ID: 234631 [Multi-domain] Cd Length: 298 Bit Score: 397.65 E-value: 2.33e-140
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| RsgA | COG1162 | Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis]; |
4-291 | 5.64e-135 | |||||
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440776 [Multi-domain] Cd Length: 300 Bit Score: 384.08 E-value: 5.64e-135
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| YjeQ_EngC | cd01854 | Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ... |
74-283 | 1.87e-102 | |||||
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain. Pssm-ID: 206747 [Multi-domain] Cd Length: 211 Bit Score: 298.16 E-value: 1.87e-102
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| TIGR00157 | TIGR00157 | ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ... |
40-283 | 1.22e-88 | |||||
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors] Pssm-ID: 272934 [Multi-domain] Cd Length: 245 Bit Score: 264.28 E-value: 1.22e-88
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| RsgA_GTPase | pfam03193 | RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ... |
61-225 | 5.51e-81 | |||||
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern. Pssm-ID: 427191 [Multi-domain] Cd Length: 174 Bit Score: 242.45 E-value: 5.51e-81
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| Name | Accession | Description | Interval | E-value | |||||
| PRK00098 | PRK00098 | GTPase RsgA; Reviewed |
4-291 | 2.33e-140 | |||||
GTPase RsgA; Reviewed Pssm-ID: 234631 [Multi-domain] Cd Length: 298 Bit Score: 397.65 E-value: 2.33e-140
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| RsgA | COG1162 | Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis]; |
4-291 | 5.64e-135 | |||||
Ribosome biogenesis GTPase RsgA [Translation, ribosomal structure and biogenesis]; Pssm-ID: 440776 [Multi-domain] Cd Length: 300 Bit Score: 384.08 E-value: 5.64e-135
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| YjeQ_EngC | cd01854 | Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; ... |
74-283 | 1.87e-102 | |||||
Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; YjeQ (YloQ in Bacillus subtilis) is a ribosomal small subunit-dependent GTPase; hence also known as RsgA. YjeQ is a late-stage ribosomal biogenesis factor involved in the 30S subunit maturation, and it represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. All YjeQ family proteins display a unique domain architecture, which includes an N-terminal OB-fold RNA-binding domain, the central permuted GTPase domain, and a zinc knuckle-like C-terminal cysteine domain. Pssm-ID: 206747 [Multi-domain] Cd Length: 211 Bit Score: 298.16 E-value: 1.87e-102
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| TIGR00157 | TIGR00157 | ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and ... |
40-283 | 1.22e-88 | |||||
ribosome small subunit-dependent GTPase A; Members of this protein were designated YjeQ and are now designated RsgA (ribosome small subunit-dependent GTPase A). The strongest motif in the alignment of these proteins is GXSGVGKS[ST], a classic P-loop for nucleotide binding. This protein has been shown to cleave GTP and remain bound to GDP. A role as a regulator of translation has been suggested. The Aquifex aeolicus ortholog is split into consecutive open reading frames. Consequently, this model was build in fragment mode (-f option). [Protein synthesis, Translation factors] Pssm-ID: 272934 [Multi-domain] Cd Length: 245 Bit Score: 264.28 E-value: 1.22e-88
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| RsgA_GTPase | pfam03193 | RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are ... |
61-225 | 5.51e-81 | |||||
RsgA GTPase; RsgA (also known as EngC and YjeQ) represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of RsgA is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern. Pssm-ID: 427191 [Multi-domain] Cd Length: 174 Bit Score: 242.45 E-value: 5.51e-81
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| PRK12288 | PRK12288 | small ribosomal subunit biogenesis GTPase RsgA; |
20-283 | 1.83e-63 | |||||
small ribosomal subunit biogenesis GTPase RsgA; Pssm-ID: 237039 [Multi-domain] Cd Length: 347 Bit Score: 203.55 E-value: 1.83e-63
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| PRK12289 | PRK12289 | small ribosomal subunit biogenesis GTPase RsgA; |
41-297 | 2.07e-60 | |||||
small ribosomal subunit biogenesis GTPase RsgA; Pssm-ID: 237040 [Multi-domain] Cd Length: 352 Bit Score: 195.62 E-value: 2.07e-60
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| PRK01889 | PRK01889 | GTPase RsgA; Reviewed |
16-285 | 6.97e-47 | |||||
GTPase RsgA; Reviewed Pssm-ID: 234988 [Multi-domain] Cd Length: 356 Bit Score: 160.87 E-value: 6.97e-47
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| RsgA_N | pfam16745 | RsgA N-terminal domain; This domain is found at the N-terminus of RsgA domains. It has an OB ... |
5-58 | 1.24e-26 | |||||
RsgA N-terminal domain; This domain is found at the N-terminus of RsgA domains. It has an OB fold. Pssm-ID: 465255 [Multi-domain] Cd Length: 54 Bit Score: 98.71 E-value: 1.24e-26
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| S1_YloQ_GTPase | cd04466 | S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. ... |
4-70 | 1.80e-23 | |||||
S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of three domains: an N-terminal S1 domain, a central GTPase domain, and a C-terminal zinc finger domain. This N-terminal S1 domain binds ssRNA. The central GTPase domain contains nucleotide-binding signature motifs: G1 (walker A), G3 (walker B) and G4 motifs. Experiments show that the bacterial YloQ and YjeQ proteins have low intrinsic GTPase activity. The C-terminal zinc-finger domain has structural similarity to a portion of the DNA-repair protein Rad51. This suggests a possible role for this GTPase as a regulator of translation, perhaps as a translation initiation factor. This family is classified based on the N-terminal S1 domain. Pssm-ID: 239912 [Multi-domain] Cd Length: 68 Bit Score: 91.08 E-value: 1.80e-23
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| MMR_HSR1 | pfam01926 | 50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ... |
163-220 | 1.33e-05 | |||||
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide. Pssm-ID: 460387 [Multi-domain] Cd Length: 113 Bit Score: 43.38 E-value: 1.33e-05
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| YqeH | cd01855 | Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH ... |
89-220 | 1.69e-05 | |||||
Circularly permuted YqeH GTPase; YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically present in bacteria with probable acquisition by plants from chloroplasts. Proteins of the YqeH family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. Pssm-ID: 206748 [Multi-domain] Cd Length: 191 Bit Score: 44.56 E-value: 1.69e-05
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| Era_like | cd00880 | E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ... |
163-220 | 3.77e-05 | |||||
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Pssm-ID: 206646 [Multi-domain] Cd Length: 161 Bit Score: 43.00 E-value: 3.77e-05
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| YeeP | COG3596 | Predicted GTPase [General function prediction only]; |
113-220 | 4.42e-04 | |||||
Predicted GTPase [General function prediction only]; Pssm-ID: 442815 [Multi-domain] Cd Length: 318 Bit Score: 41.29 E-value: 4.42e-04
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| ABCG_EPDR | cd03213 | Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ... |
156-180 | 7.77e-04 | |||||
Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus. Pssm-ID: 213180 [Multi-domain] Cd Length: 194 Bit Score: 39.84 E-value: 7.77e-04
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| 3a01205 | TIGR00956 | Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other] |
106-180 | 1.62e-03 | |||||
Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other] Pssm-ID: 273362 [Multi-domain] Cd Length: 1394 Bit Score: 40.09 E-value: 1.62e-03
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| Ras_like_GTPase | cd00882 | Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ... |
163-230 | 1.65e-03 | |||||
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions. Pssm-ID: 206648 [Multi-domain] Cd Length: 161 Bit Score: 38.21 E-value: 1.65e-03
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| COG4559 | COG4559 | ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; |
158-191 | 2.36e-03 | |||||
ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 443620 [Multi-domain] Cd Length: 258 Bit Score: 38.56 E-value: 2.36e-03
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| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
156-180 | 3.88e-03 | |||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 37.22 E-value: 3.88e-03
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| ABCG_PDR_domain2 | cd03232 | Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding ... |
158-180 | 8.72e-03 | |||||
Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213199 [Multi-domain] Cd Length: 192 Bit Score: 36.45 E-value: 8.72e-03
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