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Conserved domains on  [gi|488284155|ref|WP_002355363|]
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MULTISPECIES: ferrous iron transport protein B [Enterococcus]

Protein Classification

ferrous iron transporter B( domain architecture ID 11417566)

ferrous iron transporter B is part of an Fe(2+) uptake system that is probably driven by GTP hydrolysis

CATH:  1.10.287.1770
Gene Symbol:  feoB
Gene Ontology:  GO:0015093|GO:0005525|GO:0006826
PubMed:  12446835
SCOP:  4004042
TCDB:  9.A.8

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FeoB COG0370
Fe2+ transporter FeoB [Inorganic ion transport and metabolism];
1-673 0e+00

Fe2+ transporter FeoB [Inorganic ion transport and metabolism];


:

Pssm-ID: 440139 [Multi-domain]  Cd Length: 662  Bit Score: 936.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   1 MTQQIALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQ 79
Cdd:COG0370    2 KMITIALVGNPNVGKTTLFNALTGSRQKVGNWPGVTVEKKEGKFKlKGKEIELVDLPGTYSLSAYSPDEKVARDFLLEEK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  80 PSVILNILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDHALKQSKQ 159
Cdd:COG0370   82 PDVVVNVVDATNLERNLYLTLQLLELGIPVVLALNMMDEAEKKGIKIDVEKLSKLLGVPVVPTSARKGKGIDELKEAIIE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 160 RANAIETEVIYPSYDNRLEAALAEIVDILGNTVPEtQQRWYSLKLFERDVRTKEQLllsSFQEKEIEEVIQITEKIFQDE 239
Cdd:COG0370  162 AAEGKKPRPLRIDYPEEIEEAIEELEELLEEDGPY-PSRWLAIKLLEGDEEVLELL---SELLELLEEIREELEEELGED 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 240 SEAIIINERYAFIARLIALCATKKTEMTFTHSDKIDRVVTNRWLALPIFAFVMWLVYYLSIqTVGTMGTDWLNDVFfgEW 319
Cdd:COG0370  238 LESIIADARYAFIERILKEVVTKPGEKKLTLTDKIDRILLHPVLGIPIFLLIMFLVFQLTF-TVGAPLMDLIDGGF--GW 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 320 VPQFVGNWLAqwqvAPWMQSLILDGIIAGVGAVLGFLPQLAVLFLCLGFLEDCGYMARIAFVMDRLFRKFGLSGKSFIPM 399
Cdd:COG0370  315 LGDWVAALLP----PGWLRSLLVDGIIGGVGGVLVFLPQIAILFLFLSLLEDSGYMARAAFLMDRLMRKFGLSGKSFIPL 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 400 LIATGCGVPGVMASRTIENERDRRMTIMVTTFMPCSAKLPIIALIAGAFFP-NQSWVSPSAYFLGVASIVLSGIALKKTk 478
Cdd:COG0370  391 LSGFGCNVPAIMATRTIESPRDRLITILVAPFMSCSARLPVYALLAAAFFPdNQGLVLFSLYLLGILVALLTALLLKKT- 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 479 HFSGDPAPFIMELPAYHLPQLRSVVRHAYERCRSFVKKAGTIIFVSSILIWFMSHYSVTFQPVPESQSILAFLGKGLAVL 558
Cdd:COG0370  470 LLKGEPSPFVMELPPYRLPTLKNVLLHTWERAKAFLKKAGTIILAASIVLWFLSSFPPGGESEDLENSYLGRIGKALEPV 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 559 FIPLGWgNWQGAVATITGLIAKENIIGTLGILFGnVKDVSENGVEVWGALQHTFTPVAAYSFLTFNLLCAPCFAAIGAIR 638
Cdd:COG0370  550 FAPLGF-DWQIGVALITGFAAKEVVVGTLGTLYG-VGEDAEESASLAEALAAGFTPATALSFLVFVLLYTPCVATLAAIK 627
                        650       660       670
                 ....*....|....*....|....*....|....*
gi 488284155 639 REMGDLKWTLGAIGYQCGLAYMVSFVIYQLGHVLV 673
Cdd:COG0370  628 RETGSWKWTLFAVGYMTVLAYLVAFLVYQIGRLLG 662
 
Name Accession Description Interval E-value
FeoB COG0370
Fe2+ transporter FeoB [Inorganic ion transport and metabolism];
1-673 0e+00

Fe2+ transporter FeoB [Inorganic ion transport and metabolism];


Pssm-ID: 440139 [Multi-domain]  Cd Length: 662  Bit Score: 936.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   1 MTQQIALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQ 79
Cdd:COG0370    2 KMITIALVGNPNVGKTTLFNALTGSRQKVGNWPGVTVEKKEGKFKlKGKEIELVDLPGTYSLSAYSPDEKVARDFLLEEK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  80 PSVILNILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDHALKQSKQ 159
Cdd:COG0370   82 PDVVVNVVDATNLERNLYLTLQLLELGIPVVLALNMMDEAEKKGIKIDVEKLSKLLGVPVVPTSARKGKGIDELKEAIIE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 160 RANAIETEVIYPSYDNRLEAALAEIVDILGNTVPEtQQRWYSLKLFERDVRTKEQLllsSFQEKEIEEVIQITEKIFQDE 239
Cdd:COG0370  162 AAEGKKPRPLRIDYPEEIEEAIEELEELLEEDGPY-PSRWLAIKLLEGDEEVLELL---SELLELLEEIREELEEELGED 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 240 SEAIIINERYAFIARLIALCATKKTEMTFTHSDKIDRVVTNRWLALPIFAFVMWLVYYLSIqTVGTMGTDWLNDVFfgEW 319
Cdd:COG0370  238 LESIIADARYAFIERILKEVVTKPGEKKLTLTDKIDRILLHPVLGIPIFLLIMFLVFQLTF-TVGAPLMDLIDGGF--GW 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 320 VPQFVGNWLAqwqvAPWMQSLILDGIIAGVGAVLGFLPQLAVLFLCLGFLEDCGYMARIAFVMDRLFRKFGLSGKSFIPM 399
Cdd:COG0370  315 LGDWVAALLP----PGWLRSLLVDGIIGGVGGVLVFLPQIAILFLFLSLLEDSGYMARAAFLMDRLMRKFGLSGKSFIPL 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 400 LIATGCGVPGVMASRTIENERDRRMTIMVTTFMPCSAKLPIIALIAGAFFP-NQSWVSPSAYFLGVASIVLSGIALKKTk 478
Cdd:COG0370  391 LSGFGCNVPAIMATRTIESPRDRLITILVAPFMSCSARLPVYALLAAAFFPdNQGLVLFSLYLLGILVALLTALLLKKT- 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 479 HFSGDPAPFIMELPAYHLPQLRSVVRHAYERCRSFVKKAGTIIFVSSILIWFMSHYSVTFQPVPESQSILAFLGKGLAVL 558
Cdd:COG0370  470 LLKGEPSPFVMELPPYRLPTLKNVLLHTWERAKAFLKKAGTIILAASIVLWFLSSFPPGGESEDLENSYLGRIGKALEPV 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 559 FIPLGWgNWQGAVATITGLIAKENIIGTLGILFGnVKDVSENGVEVWGALQHTFTPVAAYSFLTFNLLCAPCFAAIGAIR 638
Cdd:COG0370  550 FAPLGF-DWQIGVALITGFAAKEVVVGTLGTLYG-VGEDAEESASLAEALAAGFTPATALSFLVFVLLYTPCVATLAAIK 627
                        650       660       670
                 ....*....|....*....|....*....|....*
gi 488284155 639 REMGDLKWTLGAIGYQCGLAYMVSFVIYQLGHVLV 673
Cdd:COG0370  628 RETGSWKWTLFAVGYMTVLAYLVAFLVYQIGRLLG 662
feoB TIGR00437
ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane ...
9-640 0e+00

ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane protein required for iron(II) update, is encoded in an operon with FeoA (75 amino acids), which is also required, and is regulated by Fur. There appear to be two copies in Archaeoglobus fulgidus and Clostridium acetobutylicum. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273077 [Multi-domain]  Cd Length: 591  Bit Score: 529.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155    9 GNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQPSVILNIL 87
Cdd:TIGR00437   1 GNPNVGKSTLFNALTGANQTVGNWPGVTVEKKEGKLGfQGEDIEIVDLPGIYSLTTFSLEEEVARDYLLNEKPDLVVNVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   88 DVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDhalkqskqranaiete 167
Cdd:TIGR00437  81 DASNLERNLYLTLQLLELGIPMILALNLVDEAEKKGIRIDEEKLEERLGVPVVPTSATEGRGIE---------------- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  168 viypsydnRLEAALAEIVDILGNT------VPETQQ-RWYSLKLFERDVRTKEQLLlsSFQEKEIEEVIQITEKIFQDES 240
Cdd:TIGR00437 145 --------RLKDAIRKAIGLKELKkraieiVPEAYQvVEVVEGLIEIIYSISKRGL--EILLGLLEDLSLEIEKIERNLA 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  241 EAIIINERYAFIARLIALcatkktEMTFTHSDKIDRVVTNRWLALPIFAFVMWLVYYLSIqTVGTMGTDWLnDVFFG--- 317
Cdd:TIGR00437 215 EVVIKESPSNLSPTEIAD------EDRVLVEKSIGRKILDRFLGLPIFLFVMFILFLLTF-LVGQPLVDLI-ETGFSfls 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  318 EWVPQFVGNWlaqwqvapWMQSLILDGIIAGVGAVLGFLPQLAVLFLCLGFLEDCGYMARIAFVMDRLFRKFGLSGKSFI 397
Cdd:TIGR00437 287 EAVKSFIGNY--------WLASLLGDGLIGGVGAVLSFVPLIAILFLALSFLEDSGYLARAAFLMDGIMNKFGLSGRAFI 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  398 PMLIATGCGVPGVMASRTIENERDRRMTIMVTTFMPCSAKLPIIALIAGAFFP--NQSWVSPSAYFLGVASIVLSGIALK 475
Cdd:TIGR00437 359 PLILGFGCNVPAIMATRTLETRRERLLTALVIPFMSCSARLPVIVLLFAAAFPgkYGGIVIFSLYLLGFVAALITARLLP 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  476 KTkHFSGDPAPFIMELPAYHLPQLRSVVRHAYERCRSFVKKAGTIIFVSSILIWFMShysvTFQPVPESQSILAFLGKGL 555
Cdd:TIGR00437 439 GE-VFKGERSPFIMELPPYRLPRFRVVFIQTWTRLRSFIKKAGTIIVIGSVLIWFLS----SFPGGKILESWLAAIGSIM 513
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  556 AVLFIPLGWG-NWQGAVATITGLIAKENIIGTLGILFGNVKDVSengvevwgALQHTFTPVAAYSFLTFNLLCAPCFAAI 634
Cdd:TIGR00437 514 APLFVPLGKIlDWFASVALIFGFVAKEVVVATLGVLYGLGNILS--------SIGHAMVPVEALSYMLFVLLYVPCLATL 585

                  ....*.
gi 488284155  635 GAIRRE 640
Cdd:TIGR00437 586 AAIARE 591
feoB PRK09554
Fe(2+) transporter permease subunit FeoB;
5-668 5.80e-169

Fe(2+) transporter permease subunit FeoB;


Pssm-ID: 236563 [Multi-domain]  Cd Length: 772  Bit Score: 504.25  E-value: 5.80e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   5 IALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEG-VAKKDKTLIIQDLPGIYSLSPYTPE----EIVARDYLLEDQ 79
Cdd:PRK09554   6 IGLIGNPNSGKTTLFNQLTGARQRVGNWAGVTVERKEGqFSTTDHQVTLVDLPGTYSLTTISSQtsldEQIACHYILSGD 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  80 PSVILNILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDhALKQS-- 157
Cdd:PRK09554  86 ADLLINVVDASNLERNLYLTLQLLELGIPCIVALNMLDIAEKQNIRIDIDALSARLGCPVIPLVSTRGRGIE-ALKLAid 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 158 KQRANAIETEVIYPSYdnrLEAALAEIVDILGNTVPETQQRWYSLKLFERDVRTKEQLLLSSFQEKEIEEVIQITekifQ 237
Cdd:PRK09554 165 RHQANENVELVHYPQP---LLNEADSLAKVMPSDIPLQQRRWLGLQMLEGDIYSRAYAGEASQHLDAALARLRNE----M 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 238 DESEAIIINERYAFIARLIALCATKKTEMTFTHSDKIDRVVTNRWLALPIFAFVMWLVYYLSIQTVGTM----------- 306
Cdd:PRK09554 238 DDPALHIADARYQCIAAICDAVSNTLTAEPSRLTTALDKIILNRWLGLPIFLFVMYLMFLLAINIGGALqplfdvgsvai 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 307 ---GTDWLNDVF-FGEWVPQFvgnwLAQwqvapwmqslildGIIAGVGAVLGFLPQLAVLFLCLGFLEDCGYMARIAFVM 382
Cdd:PRK09554 318 fihGIQWLGYTLhFPDWLTIF----LAQ-------------GLGGGINTVLPLVPQIGMMYLFLSFLEDSGYMARAAFVM 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 383 DRLFRKFGLSGKSFIPMLIATGCGVPGVMASRTIENERDRRMTIMVTTFMPCSAKLPIIALIAGAFF-PNQSWVSPSAYF 461
Cdd:PRK09554 381 DRLMQALGLPGKSFVPLIVGFGCNVPSVMGARTLDAPRERLMTIMMAPFMSCGARLAIFAVFAAAFFgQNGALAVFSLYL 460
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 462 LGVASIVLSGIALKKTKhFSGDPAPFIMELPAYHLPQLRSVVRHAYERCRSFVKKAGTIIFVSSILIWFMSHYSVTFQPV 541
Cdd:PRK09554 461 LGIVMAILTGLMLKYTI-MRGEASPFVMELPVYHVPHLKSLLIQTWQRLKGFVLRAGKVIIIVSIFIGALNSFSLSGKIV 539
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 542 PE-SQSILAFLGKGLAVLFIPLGW--GNWQGAVATITGLIAKENIIGTLGILF------------------GNVKDVSEn 600
Cdd:PRK09554 540 DNiNDSALASVSRVITPVLKPIGVheDNWQATVGLFTGAMAKEVVVGTLNTLYtaeniqdeefnpaefnlgDELFGAVD- 618
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 601 gvEVWGALQHTFT-------------------------------PVAAYSFLTFNLLCAPCFAAIGAIRREMGDlKWTLG 649
Cdd:PRK09554 619 --ETWQSLKDTFSlsvlanpieaskgdgemgtgamgvmsqkfgsAAAAYSYLIFVLLYVPCISVMGAIARESSR-GWMGF 695
                        730
                 ....*....|....*....
gi 488284155 650 AIGYQCGLAYMVSFVIYQL 668
Cdd:PRK09554 696 SILWGLNIAYSLATLFYQV 714
FeoB_N pfam02421
Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) ...
5-156 7.88e-90

Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 460552 [Multi-domain]  Cd Length: 156  Bit Score: 277.41  E-value: 7.88e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155    5 IALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQPSVI 83
Cdd:pfam02421   3 IALVGNPNVGKTTLFNALTGANQHVGNWPGVTVEKKEGKFKyKGYEIEIVDLPGIYSLSPYSEEERVARDYLLNEKPDVI 82
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488284155   84 LNILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDHALKQ 156
Cdd:pfam02421  83 VNVVDATNLERNLYLTLQLLELGLPVVLALNMMDEAEKKGIKIDIKKLSELLGVPVVPTSARKGEGIDELLDA 155
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
6-163 4.43e-87

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 270.48  E-value: 4.43e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   6 ALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQPSVIL 84
Cdd:cd01879    1 ALVGNPNVGKTTLFNALTGARQKVGNWPGVTVEKKEGEFKlGGKEIEIVDLPGTYSLTPYSEDEKVARDFLLGEEPDLIV 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488284155  85 NILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDHALKQSKQRANA 163
Cdd:cd01879   81 NVVDATNLERNLYLTLQLLELGLPVVVALNMIDEAEKRGIKIDLDKLSELLGVPVVPTSARKGEGIDELLDAIAKLAES 159
 
Name Accession Description Interval E-value
FeoB COG0370
Fe2+ transporter FeoB [Inorganic ion transport and metabolism];
1-673 0e+00

Fe2+ transporter FeoB [Inorganic ion transport and metabolism];


Pssm-ID: 440139 [Multi-domain]  Cd Length: 662  Bit Score: 936.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   1 MTQQIALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQ 79
Cdd:COG0370    2 KMITIALVGNPNVGKTTLFNALTGSRQKVGNWPGVTVEKKEGKFKlKGKEIELVDLPGTYSLSAYSPDEKVARDFLLEEK 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  80 PSVILNILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDHALKQSKQ 159
Cdd:COG0370   82 PDVVVNVVDATNLERNLYLTLQLLELGIPVVLALNMMDEAEKKGIKIDVEKLSKLLGVPVVPTSARKGKGIDELKEAIIE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 160 RANAIETEVIYPSYDNRLEAALAEIVDILGNTVPEtQQRWYSLKLFERDVRTKEQLllsSFQEKEIEEVIQITEKIFQDE 239
Cdd:COG0370  162 AAEGKKPRPLRIDYPEEIEEAIEELEELLEEDGPY-PSRWLAIKLLEGDEEVLELL---SELLELLEEIREELEEELGED 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 240 SEAIIINERYAFIARLIALCATKKTEMTFTHSDKIDRVVTNRWLALPIFAFVMWLVYYLSIqTVGTMGTDWLNDVFfgEW 319
Cdd:COG0370  238 LESIIADARYAFIERILKEVVTKPGEKKLTLTDKIDRILLHPVLGIPIFLLIMFLVFQLTF-TVGAPLMDLIDGGF--GW 314
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 320 VPQFVGNWLAqwqvAPWMQSLILDGIIAGVGAVLGFLPQLAVLFLCLGFLEDCGYMARIAFVMDRLFRKFGLSGKSFIPM 399
Cdd:COG0370  315 LGDWVAALLP----PGWLRSLLVDGIIGGVGGVLVFLPQIAILFLFLSLLEDSGYMARAAFLMDRLMRKFGLSGKSFIPL 390
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 400 LIATGCGVPGVMASRTIENERDRRMTIMVTTFMPCSAKLPIIALIAGAFFP-NQSWVSPSAYFLGVASIVLSGIALKKTk 478
Cdd:COG0370  391 LSGFGCNVPAIMATRTIESPRDRLITILVAPFMSCSARLPVYALLAAAFFPdNQGLVLFSLYLLGILVALLTALLLKKT- 469
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 479 HFSGDPAPFIMELPAYHLPQLRSVVRHAYERCRSFVKKAGTIIFVSSILIWFMSHYSVTFQPVPESQSILAFLGKGLAVL 558
Cdd:COG0370  470 LLKGEPSPFVMELPPYRLPTLKNVLLHTWERAKAFLKKAGTIILAASIVLWFLSSFPPGGESEDLENSYLGRIGKALEPV 549
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 559 FIPLGWgNWQGAVATITGLIAKENIIGTLGILFGnVKDVSENGVEVWGALQHTFTPVAAYSFLTFNLLCAPCFAAIGAIR 638
Cdd:COG0370  550 FAPLGF-DWQIGVALITGFAAKEVVVGTLGTLYG-VGEDAEESASLAEALAAGFTPATALSFLVFVLLYTPCVATLAAIK 627
                        650       660       670
                 ....*....|....*....|....*....|....*
gi 488284155 639 REMGDLKWTLGAIGYQCGLAYMVSFVIYQLGHVLV 673
Cdd:COG0370  628 RETGSWKWTLFAVGYMTVLAYLVAFLVYQIGRLLG 662
feoB TIGR00437
ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane ...
9-640 0e+00

ferrous iron transporter FeoB; FeoB (773 amino acids in E. coli), a cytoplasmic membrane protein required for iron(II) update, is encoded in an operon with FeoA (75 amino acids), which is also required, and is regulated by Fur. There appear to be two copies in Archaeoglobus fulgidus and Clostridium acetobutylicum. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273077 [Multi-domain]  Cd Length: 591  Bit Score: 529.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155    9 GNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQPSVILNIL 87
Cdd:TIGR00437   1 GNPNVGKSTLFNALTGANQTVGNWPGVTVEKKEGKLGfQGEDIEIVDLPGIYSLTTFSLEEEVARDYLLNEKPDLVVNVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   88 DVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDhalkqskqranaiete 167
Cdd:TIGR00437  81 DASNLERNLYLTLQLLELGIPMILALNLVDEAEKKGIRIDEEKLEERLGVPVVPTSATEGRGIE---------------- 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  168 viypsydnRLEAALAEIVDILGNT------VPETQQ-RWYSLKLFERDVRTKEQLLlsSFQEKEIEEVIQITEKIFQDES 240
Cdd:TIGR00437 145 --------RLKDAIRKAIGLKELKkraieiVPEAYQvVEVVEGLIEIIYSISKRGL--EILLGLLEDLSLEIEKIERNLA 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  241 EAIIINERYAFIARLIALcatkktEMTFTHSDKIDRVVTNRWLALPIFAFVMWLVYYLSIqTVGTMGTDWLnDVFFG--- 317
Cdd:TIGR00437 215 EVVIKESPSNLSPTEIAD------EDRVLVEKSIGRKILDRFLGLPIFLFVMFILFLLTF-LVGQPLVDLI-ETGFSfls 286
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  318 EWVPQFVGNWlaqwqvapWMQSLILDGIIAGVGAVLGFLPQLAVLFLCLGFLEDCGYMARIAFVMDRLFRKFGLSGKSFI 397
Cdd:TIGR00437 287 EAVKSFIGNY--------WLASLLGDGLIGGVGAVLSFVPLIAILFLALSFLEDSGYLARAAFLMDGIMNKFGLSGRAFI 358
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  398 PMLIATGCGVPGVMASRTIENERDRRMTIMVTTFMPCSAKLPIIALIAGAFFP--NQSWVSPSAYFLGVASIVLSGIALK 475
Cdd:TIGR00437 359 PLILGFGCNVPAIMATRTLETRRERLLTALVIPFMSCSARLPVIVLLFAAAFPgkYGGIVIFSLYLLGFVAALITARLLP 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  476 KTkHFSGDPAPFIMELPAYHLPQLRSVVRHAYERCRSFVKKAGTIIFVSSILIWFMShysvTFQPVPESQSILAFLGKGL 555
Cdd:TIGR00437 439 GE-VFKGERSPFIMELPPYRLPRFRVVFIQTWTRLRSFIKKAGTIIVIGSVLIWFLS----SFPGGKILESWLAAIGSIM 513
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  556 AVLFIPLGWG-NWQGAVATITGLIAKENIIGTLGILFGNVKDVSengvevwgALQHTFTPVAAYSFLTFNLLCAPCFAAI 634
Cdd:TIGR00437 514 APLFVPLGKIlDWFASVALIFGFVAKEVVVATLGVLYGLGNILS--------SIGHAMVPVEALSYMLFVLLYVPCLATL 585

                  ....*.
gi 488284155  635 GAIRRE 640
Cdd:TIGR00437 586 AAIARE 591
feoB PRK09554
Fe(2+) transporter permease subunit FeoB;
5-668 5.80e-169

Fe(2+) transporter permease subunit FeoB;


Pssm-ID: 236563 [Multi-domain]  Cd Length: 772  Bit Score: 504.25  E-value: 5.80e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   5 IALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEG-VAKKDKTLIIQDLPGIYSLSPYTPE----EIVARDYLLEDQ 79
Cdd:PRK09554   6 IGLIGNPNSGKTTLFNQLTGARQRVGNWAGVTVERKEGqFSTTDHQVTLVDLPGTYSLTTISSQtsldEQIACHYILSGD 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  80 PSVILNILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDhALKQS-- 157
Cdd:PRK09554  86 ADLLINVVDASNLERNLYLTLQLLELGIPCIVALNMLDIAEKQNIRIDIDALSARLGCPVIPLVSTRGRGIE-ALKLAid 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 158 KQRANAIETEVIYPSYdnrLEAALAEIVDILGNTVPETQQRWYSLKLFERDVRTKEQLLLSSFQEKEIEEVIQITekifQ 237
Cdd:PRK09554 165 RHQANENVELVHYPQP---LLNEADSLAKVMPSDIPLQQRRWLGLQMLEGDIYSRAYAGEASQHLDAALARLRNE----M 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 238 DESEAIIINERYAFIARLIALCATKKTEMTFTHSDKIDRVVTNRWLALPIFAFVMWLVYYLSIQTVGTM----------- 306
Cdd:PRK09554 238 DDPALHIADARYQCIAAICDAVSNTLTAEPSRLTTALDKIILNRWLGLPIFLFVMYLMFLLAINIGGALqplfdvgsvai 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 307 ---GTDWLNDVF-FGEWVPQFvgnwLAQwqvapwmqslildGIIAGVGAVLGFLPQLAVLFLCLGFLEDCGYMARIAFVM 382
Cdd:PRK09554 318 fihGIQWLGYTLhFPDWLTIF----LAQ-------------GLGGGINTVLPLVPQIGMMYLFLSFLEDSGYMARAAFVM 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 383 DRLFRKFGLSGKSFIPMLIATGCGVPGVMASRTIENERDRRMTIMVTTFMPCSAKLPIIALIAGAFF-PNQSWVSPSAYF 461
Cdd:PRK09554 381 DRLMQALGLPGKSFVPLIVGFGCNVPSVMGARTLDAPRERLMTIMMAPFMSCGARLAIFAVFAAAFFgQNGALAVFSLYL 460
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 462 LGVASIVLSGIALKKTKhFSGDPAPFIMELPAYHLPQLRSVVRHAYERCRSFVKKAGTIIFVSSILIWFMSHYSVTFQPV 541
Cdd:PRK09554 461 LGIVMAILTGLMLKYTI-MRGEASPFVMELPVYHVPHLKSLLIQTWQRLKGFVLRAGKVIIIVSIFIGALNSFSLSGKIV 539
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 542 PE-SQSILAFLGKGLAVLFIPLGW--GNWQGAVATITGLIAKENIIGTLGILF------------------GNVKDVSEn 600
Cdd:PRK09554 540 DNiNDSALASVSRVITPVLKPIGVheDNWQATVGLFTGAMAKEVVVGTLNTLYtaeniqdeefnpaefnlgDELFGAVD- 618
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155 601 gvEVWGALQHTFT-------------------------------PVAAYSFLTFNLLCAPCFAAIGAIRREMGDlKWTLG 649
Cdd:PRK09554 619 --ETWQSLKDTFSlsvlanpieaskgdgemgtgamgvmsqkfgsAAAAYSYLIFVLLYVPCISVMGAIARESSR-GWMGF 695
                        730
                 ....*....|....*....
gi 488284155 650 AIGYQCGLAYMVSFVIYQL 668
Cdd:PRK09554 696 SILWGLNIAYSLATLFYQV 714
FeoB_N pfam02421
Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) ...
5-156 7.88e-90

Ferrous iron transport protein B; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 460552 [Multi-domain]  Cd Length: 156  Bit Score: 277.41  E-value: 7.88e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155    5 IALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQPSVI 83
Cdd:pfam02421   3 IALVGNPNVGKTTLFNALTGANQHVGNWPGVTVEKKEGKFKyKGYEIEIVDLPGIYSLSPYSEEERVARDYLLNEKPDVI 82
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488284155   84 LNILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDHALKQ 156
Cdd:pfam02421  83 VNVVDATNLERNLYLTLQLLELGLPVVLALNMMDEAEKKGIKIDIKKLSELLGVPVVPTSARKGEGIDELLDA 155
FeoB cd01879
Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) ...
6-163 4.43e-87

Ferrous iron transport protein B (FeoB) family; Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent.


Pssm-ID: 206667 [Multi-domain]  Cd Length: 159  Bit Score: 270.48  E-value: 4.43e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   6 ALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQPSVIL 84
Cdd:cd01879    1 ALVGNPNVGKTTLFNALTGARQKVGNWPGVTVEKKEGEFKlGGKEIEIVDLPGTYSLTPYSEDEKVARDFLLGEEPDLIV 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488284155  85 NILDVTNLERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDHALKQSKQRANA 163
Cdd:cd01879   81 NVVDATNLERNLYLTLQLLELGLPVVVALNMIDEAEKRGIKIDLDKLSELLGVPVVPTSARKGEGIDELLDAIAKLAES 159
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
6-156 2.44e-21

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 91.15  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   6 ALAGNPNSGKTTTFNMLTGANQ-YVGNWPGVT--VERKEGVAKKDKTLIIQDLPGIYSLSPYTpEEIVARDYLLEDQPSV 82
Cdd:cd00880    1 AIFGRPNVGKSSLLNALLGQNVgIVSPIPGTTrdPVRKEWELLPLGPVVLIDTPGLDEEGGLG-RERVEEARQVADRADL 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488284155  83 ILNILDVTNLERNLYLTTQ-LIETGLPVVCALNMMDLLEKNGQ--TLNSEKLSYGLGVPVVEISALKNRGLDhALKQ 156
Cdd:cd00880   80 VLLVVDSDLTPVEEEAKLGlLRERGKPVLLVLNKIDLVPESEEeeLLRERKLELLPDLPVIAVSALPGEGID-ELRK 155
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
4-115 1.08e-19

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 84.98  E-value: 1.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155    4 QIALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEG-VAKKDKTLIIQDLPGIYSLSpyTPEEIVARDYLLEDQPSV 82
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSDYPGTTRDPNEGrLELKGKQIILVDTPGLIEGA--SEGEGLGRAFLAIIEADL 78
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 488284155   83 ILNILDVTNL--ERNLYLTTQLIETGLPVVCALNM 115
Cdd:pfam01926  79 ILFVVDSEEGitPLDEELLELLRENKKPIILVLNK 113
FeoB_Cyto pfam17910
FeoB cytosolic helical domain; FeoB is a G-protein coupled membrane protein essential for Fe ...
173-259 1.36e-19

FeoB cytosolic helical domain; FeoB is a G-protein coupled membrane protein essential for Fe(II) uptake in prokaryotes. In the structures, a canonical G-protein domain (G domain) is followed by a helical bundle domain (S-domain) which is represented by this entry.


Pssm-ID: 465561 [Multi-domain]  Cd Length: 90  Bit Score: 83.83  E-value: 1.36e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  173 YDNRLEAALAEIVDIL-GNTVPETQQRWYSLKLFERDVRTKEQLLLSSFQEKEIEEVIQITEKIFQDESEAIIINERYAF 251
Cdd:pfam17910   1 YGEEIEEAISEIEPLLeEDLEDKYPPRWLAIKLLEGDEEVLEKLKLSEELLEELEEIREELEKELGEDLESIIADARYGF 80

                  ....*...
gi 488284155  252 IARLIALC 259
Cdd:pfam17910  81 IEGILKEV 88
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
6-156 1.48e-17

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 80.58  E-value: 1.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   6 ALAGNPNSGKTTTFNMLTGANQY-VGNWPGVTVERKEGVA---KKDKTLIIQDLPGIYSlSPYTPEEIVARDYLleDQPS 81
Cdd:cd00882    1 VVVGRGGVGKSSLLNALLGGEVGeVSDVPGTTRDPDVYVKeldKGKVKLVLVDTPGLDE-FGGLGREELARLLL--RGAD 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  82 VILNILDVTNLE----RNLYLTTQLIETGLPVVCALNMMDLLEKNG--QTLNSEKLSYGLGVPVVEISALKNRGLDHALK 155
Cdd:cd00882   78 LILLVVDSTDREseedAKLLILRRLRKEGIPIILVGNKIDLLEEREveELLRLEELAKILGVPVFEVSAKTGEGVDELFE 157

                 .
gi 488284155 156 Q 156
Cdd:cd00882  158 K 158
FeoB_C pfam07664
Ferrous iron transport protein B C terminus; Escherichia coli has an iron(II) transport system ...
457-506 5.27e-15

Ferrous iron transport protein B C terminus; Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N-terminus has been previously erroneously described as being ATP-binding. Recent work shows that it is similar to eukaryotic G-proteins and that it is a GTPase.


Pssm-ID: 462224 [Multi-domain]  Cd Length: 51  Bit Score: 69.36  E-value: 5.27e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 488284155  457 PSAYFLGVASIVLSGIALKKTKHFSGDPAPFIMELPAYHLPQLRSVVRHA 506
Cdd:pfam07664   2 FSLYLLGILVALLVALLLKKTTLLKGEPSPFVMELPPYRLPTLKNVLRKT 51
Gate pfam07670
Nucleoside recognition; This region in the nucleoside transporter proteins are responsible for ...
352-445 6.65e-15

Nucleoside recognition; This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins. In the FeoB proteins, which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.


Pssm-ID: 429586 [Multi-domain]  Cd Length: 101  Bit Score: 70.75  E-value: 6.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  352 VLGFLPQLAVLFLCLGFLEDCGYMARIAFVMDRLFRKFG---LSGKSFIPMLIATGC---GVPGVMASRTIENERDRRMT 425
Cdd:pfam07670   1 LLKVLPIILFFSVLISILEYSGLLDRIGKLLGPLMRPLGlfpLPGKAAIALLLGFGAkevGVPLLATPYGIDTPRERLAA 80
                          90       100
                  ....*....|....*....|.
gi 488284155  426 IMVTTFM-PCSAKLPIIALIA 445
Cdd:pfam07670  81 LLFTSFStPCGATLPVYAGEL 101
Gate pfam07670
Nucleoside recognition; This region in the nucleoside transporter proteins are responsible for ...
514-641 1.12e-10

Nucleoside recognition; This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins. In the FeoB proteins, which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'.


Pssm-ID: 429586 [Multi-domain]  Cd Length: 101  Bit Score: 58.80  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  514 VKKAGTIIFVSSILIWFMSHYsvtfqpvpesqSILAFLGKGLAVLFIPLGWG--NWQGAVATITGLIAKENIIGTLGILF 591
Cdd:pfam07670   1 LLKVLPIILFFSVLISILEYS-----------GLLDRIGKLLGPLMRPLGLFplPGKAAIALLLGFGAKEVGVPLLATPY 69
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 488284155  592 GnvkdvsengvevwgalqhTFTPVAAYSFLTFNLLCAPCFAAIGAIRREM 641
Cdd:pfam07670  70 G------------------IDTPRERLAALLFTSFSTPCGATLPVYAGEL 101
EngA1 cd01894
EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first ...
6-151 3.88e-09

EngA1 GTPase contains the first domain of EngA; This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206681 [Multi-domain]  Cd Length: 157  Bit Score: 55.90  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   6 ALAGNPNSGKTTTFNMLTGANQ-YVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQPSVI 83
Cdd:cd01894    1 AIVGRPNVGKSTLFNRLTGRRDaIVSDTPGVTRDRKYGEAEwGGREFILIDTGGIEPDDEGISKEIREQAEIAIEEADVI 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  84 LNILDVTN--LERNLYLTTQLIETGLPVVCALNMMDLLEKngQTLNSEKLSYGLGVPVVeISALKNRGLD 151
Cdd:cd01894   81 LFVVDGREglTPADEEIAKYLRKSKKPVILVVNKIDNIKE--EEEAAEFYSLGFGEPIP-ISAEHGRGIG 147
Obg_like cd01881
Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; ...
6-154 4.56e-09

Obg-like family of GTPases consist of five subfamilies: Obg, DRG, YyaF/YchF, Ygr210, and NOG1; The Obg-like subfamily consists of five well-delimited, ancient subfamilies, namely Obg, DRG, YyaF/YchF, Ygr210, and NOG1. Four of these groups (Obg, DRG, YyaF/YchF, and Ygr210) are characterized by a distinct glycine-rich motif immediately following the Walker B motif (G3 box). Obg/CgtA is an essential gene that is involved in the initiation of sporulation and DNA replication in the bacteria Caulobacter and Bacillus, but its exact molecular role is unknown. Furthermore, several OBG family members possess a C-terminal RNA-binding domain, the TGS domain, which is also present in threonyl-tRNA synthetase and in bacterial guanosine polyphosphatase SpoT. Nog1 is a nucleolar protein that might function in ribosome assembly. The DRG and Nog1 subfamilies are ubiquitous in archaea and eukaryotes, the Ygr210 subfamily is present in archaea and fungi, and the Obg and YyaF/YchF subfamilies are ubiquitous in bacteria and eukaryotes. The Obg/Nog1 and DRG subfamilies appear to form one major branch of the Obg family and the Ygr210 and YchF subfamilies form another branch. No GEFs, GAPs, or GDIs for Obg have been identified.


Pssm-ID: 206668 [Multi-domain]  Cd Length: 167  Bit Score: 56.25  E-value: 4.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   6 ALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAKKDKTLIIQ--DLPGiysLSPYTPEEIVARDYLLED--QPS 81
Cdd:cd01881    1 GLVGLPNVGKSTLLSALTSAKVEIASYPFTTLEPNVGVFEFGDGVDIQiiDLPG---LLDGASEGRGLGEQILAHlyRSD 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  82 VILNILDVTNLERNLYLTTQLI-----------ETGLPVVCALNMMDLLEKNgQTLNSEKLSYGLGVPVVEISALKNRGL 150
Cdd:cd01881   78 LILHVIDASEDCVGDPLEDQKTlneevsgsflfLKNKPEMIVANKIDMASEN-NLKRLKLDKLKRGIPVVPTSALTRLGL 156

                 ....
gi 488284155 151 DHAL 154
Cdd:cd01881  157 DRVI 160
EngA2 cd01895
EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second ...
4-159 8.57e-09

EngA2 GTPase contains the second domain of EngA; This EngA2 subfamily CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.


Pssm-ID: 206682 [Multi-domain]  Cd Length: 174  Bit Score: 55.52  E-value: 8.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   4 QIALAGNPNSGKTTTFNMLTGANQY-VGNWPGVTveR---KEGVAKKDKTLIIQDLPGI------------YSlspytpe 67
Cdd:cd01895    4 KIAIIGRPNVGKSSLLNALLGEERViVSDIAGTT--RdsiDVPFEYDGQKYTLIDTAGIrkkgkvtegiekYS------- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  68 eiVARDYLLEDQPSVILNILDVTN--LERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNS------EKLSYGLGVPV 139
Cdd:cd01895   75 --VLRTLKAIERADVVLLVLDASEgiTEQDLRIAGLILEEGKALIIVVNKWDLVEKDEKTMKEfekelrRKLPFLDYAPI 152
                        170       180
                 ....*....|....*....|
gi 488284155 140 VEISALKNRGLDHALKQSKQ 159
Cdd:cd01895  153 VFISALTGQGVDKLFDAIKE 172
HflX cd01878
HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment ...
4-156 3.95e-08

HflX GTPase family; HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual biological functions of these GTPases remain unclear. HflX is widespread, but not universally represented in all three superkingdoms.


Pssm-ID: 206666 [Multi-domain]  Cd Length: 204  Bit Score: 54.00  E-value: 3.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   4 QIALAGNPNSGKTTTFNMLTGANQYVGN--------------WPGV-------TVerkeGvakkdktlIIQDLP-----G 57
Cdd:cd01878   43 TVALVGYTNAGKSTLFNALTGADVLAEDqlfatldpttrrikLPGGrevlltdTV----G--------FIRDLPhqlveA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  58 IYSlspyTPEEIVARDylledqpsVILNILDVTNLERNLYLTT------QLIETGLPVVCALNMMDLLEKngqtLNSEKL 131
Cdd:cd01878  111 FRS----TLEEVAEAD--------LLLHVVDASDPDREEQIETveevlkELGADDIPIILVLNKIDLLDD----EELEER 174
                        170       180
                 ....*....|....*....|....*
gi 488284155 132 SYGLGVPVVEISALKNRGLDhALKQ 156
Cdd:cd01878  175 LRAGRPDAVFISAKTGEGLD-LLKE 198
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
5-155 2.46e-07

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 50.83  E-value: 2.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155    5 IALAGNPNSGKTTTFNMLTGANQYVGN-WPGVT---VERKEGVAKKDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQP 80
Cdd:TIGR00231   4 IVIVGHPNVGKSTLLNSLLGNKGSITEyYPGTTrnyVTTVIEEDGKTYKFNLLDTAGQEDYDAIRRLYYPQVERSLRVFD 83
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488284155   81 SVILnILDVTN-LERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGVPVVEISALKNRGLDHALK 155
Cdd:TIGR00231  84 IVIL-VLDVEEiLEKQTKEIIHHADSGVPIILVGNKIDLKDADLKTHVASEFAKLNGEPIIPLSAETGKNIDSAFK 158
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
1-151 2.97e-05

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 46.94  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   1 MTQQIALAGNPNSGKTTTFNMLTGANQ-YVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIyslspytpeEIVARDYLLE- 77
Cdd:COG1160    1 MSPVVAIVGRPNVGKSTLFNRLTGRRDaIVDDTPGVTRDRIYGEAEwGGREFTLIDTGGI---------EPDDDDGLEAe 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  78 ---------DQPSVILNILD----VTNLERnlYLTTQLIETGLPVVCALNMMDllEKNGQTLNSEKLSYGLGvPVVEISA 144
Cdd:COG1160   72 ireqaelaiEEADVILFVVDgragLTPLDE--EIAKLLRRSGKPVILVVNKVD--GPKREADAAEFYSLGLG-EPIPISA 146

                 ....*..
gi 488284155 145 LKNRGLD 151
Cdd:COG1160  147 EHGRGVG 153
Der COG1160
Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];
4-155 3.82e-05

Double Era-like domain GTPase Der [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440774 [Multi-domain]  Cd Length: 438  Bit Score: 46.56  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   4 QIALAGNPNSGKTTTFNMLTGANQY-VGNWPGVT-------VERKegvakkDKTLIIQDLPGI------------YSlsp 63
Cdd:COG1160  177 KIAIVGRPNVGKSSLINALLGEERViVSDIAGTTrdsidtpFERD------GKKYTLIDTAGIrrkgkvdegiekYS--- 247
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  64 ytpeeiVAR--------DylledqpsVILNILDVTN--LERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLN------ 127
Cdd:COG1160  248 ------VLRtlraieraD--------VVLLVIDATEgiTEQDLKIAGLALEAGKALVIVVNKWDLVEKDRKTREelekei 313
                        170       180
                 ....*....|....*....|....*...
gi 488284155 128 SEKLSYGLGVPVVEISALKNRGLDHALK 155
Cdd:COG1160  314 RRRLPFLDYAPIVFISALTGQGVDKLLE 341
NOG cd01897
Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in ...
5-161 3.90e-05

Nucleolar GTP-binding protein (NOG); NOG1 is a nucleolar GTP-binding protein present in eukaryotes ranging from trypanosomes to humans. NOG1 is functionally linked to ribosome biogenesis and found in association with the nuclear pore complexes and identified in many preribosomal complexes. Thus, defects in NOG1 can lead to defects in 60S biogenesis. The S. cerevisiae NOG1 gene is essential for cell viability, and mutations in the predicted G motifs abrogate function. It is a member of the ODN family of GTP-binding proteins that also includes the bacterial Obg and DRG proteins.


Pssm-ID: 206684 [Multi-domain]  Cd Length: 167  Bit Score: 44.47  E-value: 3.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   5 IALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAkKDKTLIIQ--DLPGI--YSLSPYTPEE---IVARDYLle 77
Cdd:cd01897    3 LVIAGYPNVGKSSLVNKLTRAKPEVAPYPFTTKSLFVGHF-DYKYLRWQviDTPGIldRPLEERNTIEmqaITALAHL-- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  78 dqPSVILNILDVTN-----LERNLYLTTQLIET-GLPVVCALNMMDLLEKNGQTLNSEKLSYGlGVPVVEISALKNRGLD 151
Cdd:cd01897   80 --RAAVLFFIDPSEtcgysIEEQLSLFKEIKPLfNKPVIVVLNKIDLLTEEDLSEIEKELEKE-GEEVIKISTLTEEGVD 156
                        170
                 ....*....|
gi 488284155 152 HALKQSKQRA 161
Cdd:cd01897  157 ELKNKACELL 166
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
4-159 1.17e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 45.04  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   4 QIALAGNPNSGKTTTFNMLTGANQY-VGNWPGVT-------VERKegvakkDKTLIIQDLPGI------------YSlsp 63
Cdd:PRK00093 175 KIAIIGRPNVGKSSLINALLGEERViVSDIAGTTrdsidtpFERD------GQKYTLIDTAGIrrkgkvtegvekYS--- 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  64 ytpeeiVAR--------DylledqpsVILNILDVTN--LERNLYLTTQLIETGLPVVCALNMMDLLEKNgqTLN------ 127
Cdd:PRK00093 246 ------VIRtlkaieraD--------VVLLVIDATEgiTEQDLRIAGLALEAGRALVIVVNKWDLVDEK--TMEefkkel 309
                        170       180       190
                 ....*....|....*....|....*....|..
gi 488284155 128 SEKLSYGLGVPVVEISALKNRGLDHALKQSKQ 159
Cdd:PRK00093 310 RRRLPFLDYAPIVFISALTGQGVDKLLEAIDE 341
YihA_EngB cd01876
YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli ...
4-155 1.19e-04

YihA (EngB) GTPase family; The YihA (EngB) subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and consists of the GTPase domain only (some of the eukaryotic homologs contain an N-terminal extension of about 120 residues that might be involved in organellar targeting). Homologs of yihA are found in most Gram-positive and Gram-negative pathogenic bacteria, with the exception of Mycobacterium tuberculosis. The broad-spectrum nature of YihA and its essentiality for cell viability in bacteria make it an attractive antibacterial target.


Pssm-ID: 206665 [Multi-domain]  Cd Length: 170  Bit Score: 43.27  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   4 QIALAGNPNSGKTTTFNMLTGANQ--YVGNWPGVTverkegvaKK------DKTLIIQDLP--GIYSLSPYTPEEIVA-- 71
Cdd:cd01876    1 EVAFAGRSNVGKSSLINALTNRKKlaRTSKTPGRT--------QLinffnvGDKFRLVDLPgyGYAKVSKEVREKWGKli 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  72 RDYLLEDQP--SVILnILDVTN--LERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLNSEKLSYGLGV-----PVVEI 142
Cdd:cd01876   73 EEYLENRENlkGVVL-LIDARHgpTPIDLEMLEFLEELGIPFLIVLTKADKLKKSELAKVLKKIKEELNLfnilpPVILF 151
                        170
                 ....*....|...
gi 488284155 143 SALKNRGLDHALK 155
Cdd:cd01876  152 SSKKGTGIDELRA 164
PRK09602 PRK09602
translation-associated GTPase; Reviewed
4-44 1.19e-04

translation-associated GTPase; Reviewed


Pssm-ID: 236584 [Multi-domain]  Cd Length: 396  Bit Score: 45.18  E-value: 1.19e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 488284155   4 QIALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVA 44
Cdd:PRK09602   3 TIGLVGKPNVGKSTFFNAATLADVEIANYPFTTIDPNVGVA 43
PRK00093 PRK00093
GTP-binding protein Der; Reviewed
5-151 1.84e-04

GTP-binding protein Der; Reviewed


Pssm-ID: 234628 [Multi-domain]  Cd Length: 435  Bit Score: 44.66  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   5 IALAGNPNSGKTTTFNMLTGANQ-YVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIYSLSPYTPEEIVARDYLLEDQPSV 82
Cdd:PRK00093   4 VAIVGRPNVGKSTLFNRLTGKRDaIVADTPGVTRDRIYGEAEwLGREFILIDTGGIEPDDDGFEKQIREQAELAIEEADV 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488284155  83 ILNILD----VTNLERnlYLTTQLIETGLPVVCALNMMDllEKNGQTLNSEKLSYGLGVPVVeISALKNRGLD 151
Cdd:PRK00093  84 ILFVVDgragLTPADE--EIAKILRKSNKPVILVVNKVD--GPDEEADAYEFYSLGLGEPYP-ISAEHGRGIG 151
PRK04213 PRK04213
GTP-binding protein EngB;
4-156 5.05e-04

GTP-binding protein EngB;


Pssm-ID: 179790 [Multi-domain]  Cd Length: 201  Bit Score: 41.83  E-value: 5.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   4 QIALAGNPNSGKTTTFNMLTGANQYVGNWPGVTveRKEGVAKKdKTLIIQDLPGIYSLS--PYTPEEIVARD---YLLED 78
Cdd:PRK04213  11 EIVFVGRSNVGKSTLVRELTGKKVRVGKRPGVT--RKPNHYDW-GDFILTDLPGFGFMSgvPKEVQEKIKDEivrYIEDN 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155  79 QPSVILNILDVTN------LER---------NLYLTTQLIETGLPVVCALNMMDLLEKNGQTLN--SEKLsyGLGVP--- 138
Cdd:PRK04213  88 ADRILAAVLVVDGksfieiIERwegrgeipiDVEMFDFLRELGIPPIVAVNKMDKIKNRDEVLDeiAERL--GLYPPwrq 165
                        170       180
                 ....*....|....*....|....
gi 488284155 139 ----VVEISALKNR--GLDHALKQ 156
Cdd:PRK04213 166 wqdiIAPISAKKGGieELKEAIRK 189
DRG cd01896
Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding ...
4-59 6.68e-04

Developmentally Regulated GTP-binding protein (DRG); The developmentally regulated GTP-binding protein (DRG) subfamily is an uncharacterized member of the Obg family, an evolutionary branch of GTPase superfamily proteins. GTPases act as molecular switches regulating diverse cellular processes. DRG2 and DRG1 comprise the DRG subfamily in eukaryotes. In view of their widespread expression in various tissues and high conservation among distantly related species in eukaryotes and archaea, DRG proteins may regulate fundamental cellular processes. It is proposed that the DRG subfamily proteins play their physiological roles through RNA binding.


Pssm-ID: 206683 [Multi-domain]  Cd Length: 233  Bit Score: 41.76  E-value: 6.68e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488284155   4 QIALAGNPNSGKTTTFNMLTGANQYVGNWPGVTVERKEGVAK-KDKTLIIQDLPGIY 59
Cdd:cd01896    2 RVALVGFPSVGKSTLLSKLTNTKSEVAAYEFTTLTCVPGVMEyKGAKIQLLDLPGII 58
Era cd04163
E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is ...
5-151 9.97e-04

E. coli Ras-like protein (Era) is a multifunctional GTPase; Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly by chaperoning the 16S rRNA. It also contacts several assembly elements of the 30S subunit. Era couples cell growth with cytokinesis and plays a role in cell division and energy metabolism. Homologs have also been found in eukaryotes. Era contains two domains: the N-terminal GTPase domain and a C-terminal domain KH domain that is critical for RNA binding. Both domains are important for Era function. Era is functionally able to compensate for deletion of RbfA, a cold-shock adaptation protein that is required for efficient processing of the 16S rRNA.


Pssm-ID: 206726 [Multi-domain]  Cd Length: 168  Bit Score: 40.52  E-value: 9.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284155   5 IALAGNPNSGKTTTFNMLTGAN-QYVGNWPGVTVERKEGVAKKDKT-LIIQDLPGIYslspyTPEEiVARDYLLEDQPS- 81
Cdd:cd04163    6 VAIIGRPNVGKSTLLNALVGQKiSIVSPKPQTTRNRIRGIYTDDDAqIIFVDTPGIH-----KPKK-KLGERMVKAAWSa 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488284155  82 -----VILNILDVTNL--ERNLYLTTQLIETGLPVVCALNMMDLLEKNGQTLN-SEKLS-YGLGVPVVEISALKNRGLD 151
Cdd:cd04163   80 lkdvdLVLFVVDASEWigEGDEFILELLKKSKTPVILVLNKIDLVKDKEDLLPlLEKLKeLHPFAEIFPISALKGENVD 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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