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Conserved domains on  [gi|488284811|ref|WP_002356019|]
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MULTISPECIES: 30S ribosomal protein S6 [Enterococcus]

Protein Classification

30S ribosomal protein S6( domain architecture ID 10785350)

30S ribosomal protein S6 is important for the assembly of the central domain of the small subunit via heterodimerization with ribosomal protein S18

CATH:  3.30.70.60
Gene Ontology:  GO:0005840|GO:0019843|GO:0003735|GO:0006412|GO:1990904
PubMed:  22817455
SCOP:  4001337

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpsF COG0360
Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S6 ...
 6-100 5.74e-39

Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S6 is part of the Pathway/BioSystem: Ribosome 30S subunit


:

Pssm-ID: 440129  Cd Length: 107  Bit Score: 125.29  E-value: 5.74e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   6 KYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEFDRLAK 85
Cdd:COG0360    3 HYEIVFILRPDLSEEQVEALVEKFKGIIEKNGGEIVKVEDWGKRKLAYPIKKKREGHYVLMNFEADPA--AIAELERQLR 80

                         90
                 ....*....|....*
gi 488284811  86 INDDIIRHMIVKVEA 100
Cdd:COG0360   81 INEDVLRFLTVRLDE 95
 
Name Accession Description Interval E-value
RpsF COG0360
Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S6 ...
 6-100 5.74e-39

Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S6 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 440129  Cd Length: 107  Bit Score: 125.29  E-value: 5.74e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   6 KYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEFDRLAK 85
Cdd:COG0360    3 HYEIVFILRPDLSEEQVEALVEKFKGIIEKNGGEIVKVEDWGKRKLAYPIKKKREGHYVLMNFEADPA--AIAELERQLR 80

                         90
                 ....*....|....*
gi 488284811  86 INDDIIRHMIVKVEA 100
Cdd:COG0360   81 INEDVLRFLTVRLDE 95
bS6 cd00473
Bacterial ribosomal protein S6; bS6 is one of the components of the small subunit of the ...
 6-98 1.12e-36

Bacterial ribosomal protein S6; bS6 is one of the components of the small subunit of the prokaryotic ribosome, a ribonucleoprotein organelle that decodes the genetic information in messenger RNA and forms peptide bonds to synthesize the corresponding polypeptides. Ribosomes consist of a large and a small subunit, which assemble during the initiation stage of protein synthesis. Prokaryotic ribosomes consist of three molecules of RNA and more than 50 proteins. The small subunits of bacterial and eukaryotic ribosomes have the same overall shapes (with structural elements described as head, body, platform, beak and shoulder). The bacterial ribosomal protein S6 is important for the assembly of the central domain of the small subunit via heterodimerization with ribosomal protein S18.


Pssm-ID: 275385  Cd Length: 91  Bit Score: 119.09  E-value: 1.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   6 KYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEFDRLAK 85
Cdd:cd00473    1 KYELMFILDPDLSEEEVKALIEKVKKIIEKNGGEIVKVEDWGKRKLAYPIKKKKEGYYVLINFEAEPE--AIAELERRLR 78

                         90
                 ....*....|...
gi 488284811  86 INDDIIRHMIVKV 98
Cdd:cd00473   79 INEDVLRFLIVKL 91
Ribosomal_S6 pfam01250
Ribosomal protein S6;
6-95 1.62e-35

Ribosomal protein S6;


Pssm-ID: 460134  Cd Length: 88  Bit Score: 116.02  E-value: 1.62e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811    6 KYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEFDRLAK 85
Cdd:pfam01250   1 KYELMFILRPDLSEEEVKALVEKFKALITENGGEIRKVEDWGKRRLAYPIKKHREGYYVLMNFDAPPA--AIAELERLLR 78

                          90
                  ....*....|
gi 488284811   86 INDDIIRHMI 95
Cdd:pfam01250  79 IDEDVLRFLI 88
S6 TIGR00166
ribosomal protein S6; The ribosomal protein S6 ortholog family, including yeast MRP17, shows ...
 6-99 1.53e-27

ribosomal protein S6; The ribosomal protein S6 ortholog family, including yeast MRP17, shows more than two-fold length variation from 95 residues in Bacillus subtilis to 215 in Mycoplasma pneumoniae. This length variation comes primarily from poorly conserved C-terminal extensions that are particularly long in the Mycoplasmas. MRP17 protein is a component of the small ribosomal subunit in mitochondria, and is shown here to be an ortholog of S6. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 129270  Cd Length: 93  Bit Score: 95.89  E-value: 1.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811    6 KYEIMYIIRPNIDEEAKtALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPstAGAINEFDRLAK 85
Cdd:TIGR00166   2 HYEIIFLVRPTLSEEVK-GQIERYKKVITLNGAEIVRSEDWGKRRLAYPIKKQLRAHYVLMNFSGE--AQVIKEFERTAR 78

                          90
                  ....*....|....
gi 488284811   86 INDDIIRHMIVKVE 99
Cdd:TIGR00166  79 INDNVIRSLIIKLE 92
rps6 CHL00123
ribosomal protein S6; Validated
 1-98 3.38e-17

ribosomal protein S6; Validated


Pssm-ID: 177046  Cd Length: 97  Bit Score: 70.03  E-value: 3.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   1 MSQDTKYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEF 80
Cdd:CHL00123   2 MSKLNKYETMYLLKPDLNEEELLKWIENYKKLLRKRGAKNISVQNRGKRKLSYKINKYEDGIYIQMNYSGNGK--LVNSL 79

                         90
                 ....*....|....*...
gi 488284811  81 DRLAKINDDIIRHMIVKV 98
Cdd:CHL00123  80 EKALKLDENVLRYLTFKK 97
 
Name Accession Description Interval E-value
RpsF COG0360
Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S6 ...
 6-100 5.74e-39

Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S6 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 440129  Cd Length: 107  Bit Score: 125.29  E-value: 5.74e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   6 KYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEFDRLAK 85
Cdd:COG0360    3 HYEIVFILRPDLSEEQVEALVEKFKGIIEKNGGEIVKVEDWGKRKLAYPIKKKREGHYVLMNFEADPA--AIAELERQLR 80

                         90
                 ....*....|....*
gi 488284811  86 INDDIIRHMIVKVEA 100
Cdd:COG0360   81 INEDVLRFLTVRLDE 95
bS6 cd00473
Bacterial ribosomal protein S6; bS6 is one of the components of the small subunit of the ...
 6-98 1.12e-36

Bacterial ribosomal protein S6; bS6 is one of the components of the small subunit of the prokaryotic ribosome, a ribonucleoprotein organelle that decodes the genetic information in messenger RNA and forms peptide bonds to synthesize the corresponding polypeptides. Ribosomes consist of a large and a small subunit, which assemble during the initiation stage of protein synthesis. Prokaryotic ribosomes consist of three molecules of RNA and more than 50 proteins. The small subunits of bacterial and eukaryotic ribosomes have the same overall shapes (with structural elements described as head, body, platform, beak and shoulder). The bacterial ribosomal protein S6 is important for the assembly of the central domain of the small subunit via heterodimerization with ribosomal protein S18.


Pssm-ID: 275385  Cd Length: 91  Bit Score: 119.09  E-value: 1.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   6 KYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEFDRLAK 85
Cdd:cd00473    1 KYELMFILDPDLSEEEVKALIEKVKKIIEKNGGEIVKVEDWGKRKLAYPIKKKKEGYYVLINFEAEPE--AIAELERRLR 78

                         90
                 ....*....|...
gi 488284811  86 INDDIIRHMIVKV 98
Cdd:cd00473   79 INEDVLRFLIVKL 91
Ribosomal_S6 pfam01250
Ribosomal protein S6;
6-95 1.62e-35

Ribosomal protein S6;


Pssm-ID: 460134  Cd Length: 88  Bit Score: 116.02  E-value: 1.62e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811    6 KYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEFDRLAK 85
Cdd:pfam01250   1 KYELMFILRPDLSEEEVKALVEKFKALITENGGEIRKVEDWGKRRLAYPIKKHREGYYVLMNFDAPPA--AIAELERLLR 78

                          90
                  ....*....|
gi 488284811   86 INDDIIRHMI 95
Cdd:pfam01250  79 IDEDVLRFLI 88
S6 TIGR00166
ribosomal protein S6; The ribosomal protein S6 ortholog family, including yeast MRP17, shows ...
 6-99 1.53e-27

ribosomal protein S6; The ribosomal protein S6 ortholog family, including yeast MRP17, shows more than two-fold length variation from 95 residues in Bacillus subtilis to 215 in Mycoplasma pneumoniae. This length variation comes primarily from poorly conserved C-terminal extensions that are particularly long in the Mycoplasmas. MRP17 protein is a component of the small ribosomal subunit in mitochondria, and is shown here to be an ortholog of S6. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 129270  Cd Length: 93  Bit Score: 95.89  E-value: 1.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811    6 KYEIMYIIRPNIDEEAKtALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPstAGAINEFDRLAK 85
Cdd:TIGR00166   2 HYEIIFLVRPTLSEEVK-GQIERYKKVITLNGAEIVRSEDWGKRRLAYPIKKQLRAHYVLMNFSGE--AQVIKEFERTAR 78

                          90
                  ....*....|....
gi 488284811   86 INDDIIRHMIVKVE 99
Cdd:TIGR00166  79 INDNVIRSLIIKLE 92
bS6_chloro_cyano cd15487
30S ribosomal protein S6 of chloroplasts and cyanobacteria; bS6 is one of the components of ...
 5-98 2.36e-25

30S ribosomal protein S6 of chloroplasts and cyanobacteria; bS6 is one of the components of the small subunit of the prokaryotic ribosome, a ribonucleoprotein organelle that decodes the genetic information in messenger RNA and forms peptide bonds to synthesize the corresponding polypeptides. Mitochondrial and chloroplastic ribosomes are similar to bacterial ribosomes. Ribosomes consist of a large and a small subunit, which assemble during the initiation stage of protein synthesis. Prokaryotic ribosomes consist of three molecules of RNA and more than 50 proteins. The small subunits of bacterial and eukaryotic ribosomes have the same overall shapes (with structural elements described as head, body, platform, beak and shoulder). The bacterial ribosomal protein S6 is important for the assembly of the central domain of the small subunit via heterodimerization with ribosomal protein S18.


Pssm-ID: 275387  Cd Length: 94  Bit Score: 90.34  E-value: 2.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   5 TKYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEFDRLA 84
Cdd:cd15487    3 RSYETMYILRPDLTEEQVEQLINKYQELLTENGAENIEVQNRGKRRLAYEIKKFRDGIYVQMNYTADGS--AVAPLERAM 80

                         90
                 ....*....|....
gi 488284811  85 KINDDIIRHMIVKV 98
Cdd:cd15487   81 RLSEEVIRYLTIKV 94
rps6 CHL00123
ribosomal protein S6; Validated
 1-98 3.38e-17

ribosomal protein S6; Validated


Pssm-ID: 177046  Cd Length: 97  Bit Score: 70.03  E-value: 3.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   1 MSQDTKYEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMNGFREGIYHIVNVTSPSTagAINEF 80
Cdd:CHL00123   2 MSKLNKYETMYLLKPDLNEEELLKWIENYKKLLRKRGAKNISVQNRGKRKLSYKINKYEDGIYIQMNYSGNGK--LVNSL 79

                         90
                 ....*....|....*...
gi 488284811  81 DRLAKINDDIIRHMIVKV 98
Cdd:CHL00123  80 EKALKLDENVLRYLTFKK 97
bS6_mito cd15465
Mitochondrial Ribosomal Protein (MRP) S6; bS6_MRPS6 is one of the proteins of the small ...
 7-98 1.43e-09

Mitochondrial Ribosomal Protein (MRP) S6; bS6_MRPS6 is one of the proteins of the small subunit of the mitochondrial ribosome. Mitochondrial and chloroplastic ribosomes are similar to bacterial ribosomes. The ribosome is a ribonucleoprotein organelle that decodes the genetic information in messenger RNA and forms peptide bonds to synthesize the corresponding polypeptide. Ribosomes consist of a large and a small subunit, which assemble during the initiation stage of protein synthesis. Prokaryotic ribosomes consist of three molecules of RNA and more than 50 proteins. The small subunits of bacterial and eukaryotic ribosomes have the same overall shapes (with structural elements described as head, body, platform, beak and shoulder). Mitochondrial and chloroplastic ribosomes synthesize proteins that are involved in oxidative phosphorylation (ATP generation) and photosynthesis. bS6_MRPS6 is one of the fourteen mitochondrial ribosomal proteins that is known to have significant sequence homology with their bacterial counterpart.


Pssm-ID: 275386  Cd Length: 95  Bit Score: 50.22  E-value: 1.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488284811   7 YEIMYIIRPNIDEEAKTALVERFDTILKDNGAEVIESKDWEKRRLAYEMN----GFREGIYHIVNVTSPSTagAINEFDR 82
Cdd:cd15465    2 YELVLIARALAEKAELKELLKRTAKAILDNGGVVRKIENLGTRDLPYRIKkhqeRHTEGRYFLMDFDASPT--VVKELRE 79

                         90
                 ....*....|....*.
gi 488284811  83 LAKINDDIIRHMIVKV 98
Cdd:cd15465   80 ELRRDPDVIRWSIVKL 95
DUF4471 pfam14740
Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and ...
 33-74 2.16e-03

Domain of unknown function (DUF4471); This family is conserved from fungi to Metazoa and includes plants. The function is not known, but several members have zinc-finger domain, zf-MYND, pfam01753, at their very C-terminus. Others are also associated with DUF1279, pfam06916. This domain is more C-terminal in many members to DUF4470, pfam14737.


Pssm-ID: 464292  Cd Length: 303  Bit Score: 35.32  E-value: 2.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 488284811   33 LKDNGAEVI---ESKDWEKRRLAYEmngFREGIYHIVNVTSPSTA 74
Cdd:pfam14740  62 LHDRGANVIhsqEYRRWRETGVAFE---FREGEYQVPNKTLASGR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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