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Conserved domains on  [gi|488284945|ref|WP_002356153|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Bacillota]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
2-40 5.45e-09

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 46.14  E-value: 5.45e-09
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 488284945  2 KLEQEIVNRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:COG1396   3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIE 41
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
2-40 5.45e-09

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 46.14  E-value: 5.45e-09
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 488284945  2 KLEQEIVNRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:COG1396   3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIE 41
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
10-40 2.53e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 41.35  E-value: 2.53e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 488284945   10 RIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGVSRSTLSRIE 31
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-40 3.15e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.00  E-value: 3.15e-07
                        10        20        30
                ....*....|....*....|....*....|..
gi 488284945  9 NRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:cd00093   2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIE 33
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 11-40 1.15e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 37.13  E-value: 1.15e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 488284945  11 IRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIE 30
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
2-40 5.45e-09

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 46.14  E-value: 5.45e-09
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 488284945  2 KLEQEIVNRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:COG1396   3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIE 41
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
5-40 5.73e-08

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 43.30  E-value: 5.73e-08
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 488284945  5 QEIVNRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:COG1476   3 KKLGNRLKELRKERGLTQEELAELLGVSRQTISAIE 38
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
10-40 2.53e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 41.35  E-value: 2.53e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 488284945   10 RIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:smart00530  1 RLKELREEKGLTQEELAEKLGVSRSTLSRIE 31
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 9-40 3.15e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.00  E-value: 3.15e-07
                        10        20        30
                ....*....|....*....|....*....|..
gi 488284945  9 NRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:cd00093   2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIE 33
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 10-40 5.84e-07

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 40.69  E-value: 5.84e-07
                        10        20        30
                ....*....|....*....|....*....|.
gi 488284945 10 RIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:COG1813  16 RIREAREARGLSQEELAEKLGVSESTIRRIE 46
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 11-40 1.15e-05

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 37.13  E-value: 1.15e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 488284945  11 IRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:pfam01381  1 LKELREELGLSQEELAEKLGVSRSTISKIE 30
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 4-40 1.64e-05

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 37.09  E-value: 1.64e-05
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 488284945  4 EQEIVNRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:COG1426   3 LETIGELLRQAREAKGLSLEDVAERTKISVSYLEAIE 39
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 10-40 6.43e-05

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 35.20  E-value: 6.43e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 488284945  10 RIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:pfam13560  5 RLRRLRERAGLSQEALARRLGVSRSTLSRLE 35
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
1-40 3.93e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 33.37  E-value: 3.93e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 488284945  1 MKLEQEIVNRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:COG2944   1 MTKKPLTPEEIRALRERLGLSQAEFAALLGVSVSTVRRWE 40
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 4-40 1.28e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 32.68  E-value: 1.28e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 488284945  4 EQEIVNRIRELRTSKNMTQEQLADKIGFAVSYLGRIE 40
Cdd:COG3620  15 DDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIE 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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