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Conserved domains on  [gi|488285932|ref|WP_002357140|]
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MULTISPECIES: MIP/aquaporin family protein [Enterococcus]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 4-239 2.91e-80

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 240.41  E-value: 2.91e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   4 SMMTQLFGEFFGTMILVLLGDGVCAAvnLKKSKAfASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFE 83
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAV--LAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  84 WGMVLPYIVAQVLGGFIGGLVVWLAYLPHWNITEDKGAILGTFATGPAVR-NYPANVLTEIIGTFVLVFGLLAFSQNDLA 162
Cdd:COG0580   78 WKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTFVLVFVILGITDKRAA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488285932 163 -AGINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIpvktKGDSDWAYSWVPIVGPILGASLAAVIYLFTI 239
Cdd:COG0580  158 pGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALG----KGGSDWGYLWVPIVAPILGAALAALLYRALF 231
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 4-239 2.91e-80

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 240.41  E-value: 2.91e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   4 SMMTQLFGEFFGTMILVLLGDGVCAAvnLKKSKAfASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFE 83
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAV--LAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  84 WGMVLPYIVAQVLGGFIGGLVVWLAYLPHWNITEDKGAILGTFATGPAVR-NYPANVLTEIIGTFVLVFGLLAFSQNDLA 162
Cdd:COG0580   78 WKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTFVLVFVILGITDKRAA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488285932 163 -AGINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIpvktKGDSDWAYSWVPIVGPILGASLAAVIYLFTI 239
Cdd:COG0580  158 pGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALG----KGGSDWGYLWVPIVAPILGAALAALLYRALF 231
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 11-239 1.50e-41

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 143.34  E-value: 1.50e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  11 GEFFGTMILVLLGDGVCAAVNLKKSKafaSGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMVLPY 90
Cdd:PTZ00016  55 AEFLGTFVLLFFGEGVVATTHTVGNN---GDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  91 IVAQVLGGFIGGLVVWLAYLPHW---------NITEDKGAIlGTFATGPAVRNYPAnVLTEIIGTFVLVFGLLAF--SQN 159
Cdd:PTZ00016 132 FVAQLLGAFVGAACVYGLYYGFFkdhgipelpWETMANGFA-GVFATYPREGNFYA-IFSELILTAILLLVILAItdPNN 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932 160 DLAAGINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIPVKTKGDSDWAYSWVPIVGPILGASLAAVIYLFTI 239
Cdd:PTZ00016 210 CPAFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAILWGSEVFTKDNYYFWVPLVAPFVGAVLGMFLYDKFI 289
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 8-235 2.97e-41

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 140.47  E-value: 2.97e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   8 QLFGEFFGTMILVLLGDGvcAAVNLKKSKAFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMV 87
Cdd:cd00333    2 KYLAEFLGTFLLVFFGCG--SVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  88 LPYIVAQVLGGFIGGLVVWLAYLPHWNITEDKGAILGTFATGPAVRNYPA--NVLTEIIGTFVLVFGLLAF---SQNDLA 162
Cdd:cd00333   80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPSPGVSNgnAFFVEFIGTFILVLVVFATtddPNGPPP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488285932 163 AGINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIpvktkgdSDWAYSWVPIVGPILGASLAAVIY 235
Cdd:cd00333  160 GGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA-------RHWHYFWVYWVGPLIGAIAGALVY 225
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 11-235 1.29e-34

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 123.18  E-value: 1.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   11 GEFFGTMILVLLGDGVCAAVNLKKSK--AFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMVL 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgaVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   89 PYIVAQVLGGFIGGLVVWLAYlphWNITEDKGAILGTFATGPAVRNypaNVLTEIIGTFVLVFGLLAFSQNDLA---AGI 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLT---SGLFPGNLAVNGSASAGVSSGQ---AFFVEFIGTAILVLVIFATTDDRNRvprGGF 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  166 NPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIPvktkgdsdWAYSWVPIVGPILGASLAAVIY 235
Cdd:TIGR00861 155 APLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAG--------WGNHWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 8-235 6.48e-31

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 113.57  E-value: 6.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932    8 QLFGEFFGTMILVLLGDGVCAAVNLKKSKAFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMV 87
Cdd:pfam00230  10 AVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSLLRA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   88 LPYIVAQVLGGFIGGLVVWLAYLPhwnitedkGAILGTFATGPAVRNYPANVLT-EIIGTFVLVFGLLAFS---QNDLAA 163
Cdd:pfam00230  90 IFYIVAQLLGAIAGAALLYGVTVG--------LQRAGLFANTLAPGVNAGQAFVvEIILTFQLVYCVFATTddrRNGSLG 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488285932  164 GINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHqiipvktkgdSDWAYSWVPIVGPILGASLAAVIY 235
Cdd:pfam00230 162 TVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----------WKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 4-239 2.91e-80

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 240.41  E-value: 2.91e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   4 SMMTQLFGEFFGTMILVLLGDGVCAAvnLKKSKAfASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFE 83
Cdd:COG0580    1 SLMKRLLAEFLGTFILVLLGCGVVAV--LAGTKG-GIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  84 WGMVLPYIVAQVLGGFIGGLVVWLAYLPHWNITEDKGAILGTFATGPAVR-NYPANVLTEIIGTFVLVFGLLAFSQNDLA 162
Cdd:COG0580   78 WKDVLPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLGVFATSPAIGySLGAAFLTEIIGTFVLVFVILGITDKRAA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488285932 163 -AGINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIpvktKGDSDWAYSWVPIVGPILGASLAAVIYLFTI 239
Cdd:COG0580  158 pGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALG----KGGSDWGYLWVPIVAPILGAALAALLYRALF 231
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 11-239 1.50e-41

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 143.34  E-value: 1.50e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  11 GEFFGTMILVLLGDGVCAAVNLKKSKafaSGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMVLPY 90
Cdd:PTZ00016  55 AEFLGTFVLLFFGEGVVATTHTVGNN---GDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  91 IVAQVLGGFIGGLVVWLAYLPHW---------NITEDKGAIlGTFATGPAVRNYPAnVLTEIIGTFVLVFGLLAF--SQN 159
Cdd:PTZ00016 132 FVAQLLGAFVGAACVYGLYYGFFkdhgipelpWETMANGFA-GVFATYPREGNFYA-IFSELILTAILLLVILAItdPNN 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932 160 DLAAGINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIPVKTKGDSDWAYSWVPIVGPILGASLAAVIYLFTI 239
Cdd:PTZ00016 210 CPAFNYLPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAILWGSEVFTKDNYYFWVPLVAPFVGAVLGMFLYDKFI 289
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 8-235 2.97e-41

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 140.47  E-value: 2.97e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   8 QLFGEFFGTMILVLLGDGvcAAVNLKKSKAFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMV 87
Cdd:cd00333    2 KYLAEFLGTFLLVFFGCG--SVLAVKLAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  88 LPYIVAQVLGGFIGGLVVWLAYLPHWNITEDKGAILGTFATGPAVRNYPA--NVLTEIIGTFVLVFGLLAF---SQNDLA 162
Cdd:cd00333   80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPSPGVSNgnAFFVEFIGTFILVLVVFATtddPNGPPP 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488285932 163 AGINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIpvktkgdSDWAYSWVPIVGPILGASLAAVIY 235
Cdd:cd00333  160 GGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA-------RHWHYFWVYWVGPLIGAIAGALVY 225
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 11-235 1.29e-34

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 123.18  E-value: 1.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   11 GEFFGTMILVLLGDGVCAAVNLKKSK--AFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMVL 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAYgaVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   89 PYIVAQVLGGFIGGLVVWLAYlphWNITEDKGAILGTFATGPAVRNypaNVLTEIIGTFVLVFGLLAFSQNDLA---AGI 165
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLT---SGLFPGNLAVNGSASAGVSSGQ---AFFVEFIGTAILVLVIFATTDDRNRvprGGF 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  166 NPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIPvktkgdsdWAYSWVPIVGPILGASLAAVIY 235
Cdd:TIGR00861 155 APLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAG--------WGNHWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 8-235 6.48e-31

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 113.57  E-value: 6.48e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932    8 QLFGEFFGTMILVLLGDGVCAAVNLKKSKAFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMV 87
Cdd:pfam00230  10 AVIAEFLATLLFVFFGVGSALGVKKLVSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSLLRA 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   88 LPYIVAQVLGGFIGGLVVWLAYLPhwnitedkGAILGTFATGPAVRNYPANVLT-EIIGTFVLVFGLLAFS---QNDLAA 163
Cdd:pfam00230  90 IFYIVAQLLGAIAGAALLYGVTVG--------LQRAGLFANTLAPGVNAGQAFVvEIILTFQLVYCVFATTddrRNGSLG 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488285932  164 GINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHqiipvktkgdSDWAYSWVPIVGPILGASLAAVIY 235
Cdd:pfam00230 162 TVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVL----------WKWDDHWVYWVGPFIGAALGALVY 223
PRK05420 PRK05420
aquaporin Z; Provisional
 5-235 7.09e-18

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 79.24  E-value: 7.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   5 MMTQLFGEFFGTMILVLLGDGvcAAVNLKKSKAFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEW 84
Cdd:PRK05420   1 MFKKLAAEFFGTFWLVFGGCG--SAVLAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  85 GMVLPYIVAQVLGGFIGGLVVWL--AYLPHWNITEDKGAILGTFATGPAVRNYPANVLTEIIGTFVLVFGLLAFSQNDLA 162
Cdd:PRK05420  79 KELVPYIIAQVVGGIAAAAVLYLiaSGKAGFDLAGSGFASNGYGEHSPGGYSLLAALVCEVVLTAFFLLVILGATDKRAP 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488285932 163 AGINPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHqiipvktkgdSDWAYS--WVPIVGPILGASLAAVIY 235
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFV----------GGWALEqlWLFWVAPIVGAIIGGLIY 223
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 8-237 1.52e-17

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 79.57  E-value: 1.52e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   8 QLFGEFFGTMILVLLGDGVCAAVNLKKSKAFASGwvvIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMV 87
Cdd:PLN00182  44 KLIAEMIGTYFIIFSGCGVVVVNVLYGGTITFPG---ICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  88 LPYIVAQVLGGFIGGLVVWLAYlphwNITEDkgAILGTFATGPAVRnypaNVLTEIIGTFVLVFGLLAFSQNDLAAG-IN 166
Cdd:PLN00182 121 PLYIGAQLTGSLLASLTLRLMF----NVTPE--AFFGTTPTDSSGQ----ALVAEIIISFLLMFVISGVATDSRAVGeLA 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488285932 167 PMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIipvktkgdsdWAYSWVPIVGPILGASLAAVIYLF 237
Cdd:PLN00182 191 GIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGR----------YKGIWVYIVGPFVGIIAGGFVYNL 251
PLN00184 PLN00184
aquaporin NIP1; Provisional
 6-235 1.55e-17

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 79.68  E-value: 1.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   6 MTQLFGEFFGTMILVLLGdgvCAAVNLKKSKAFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWG 85
Cdd:PLN00184  54 LQKLIAEVLGTYFLVFTG---CASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  86 MVLPYIVAQVLGGFIGGLVVWLAY-LPHWNITEDKGAILGTFATGPAVRNYpanvLTEIIGTFVLVFGLLAFSQNDLAAG 164
Cdd:PLN00184 131 QVPAYVISQVIGSTLAAATLRLLFgLDHDVCSGKHDVFIGSSPVGSDLQAF----VMEFIVTFYLMFIISGVATDNRAIG 206

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488285932 165 -INPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHqiipvktkgdSDWAYSWVPIVGPILGASLAAVIY 235
Cdd:PLN00184 207 eLAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVY----------GCYKGIWIYIVAPTLGAIAGAWVY 268
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 9-236 3.44e-13

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 67.19  E-value: 3.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   9 LFGEFFGTMILVLLGDGVCAAVNLKKSKAfasGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMVL 88
Cdd:PLN00183  48 VLAEMVGTFILMFCVCGIIASTQLSGGEV---GLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  89 PYIVAQVLGGFIGGLVVWLAYlphwnitedkGAILGTFATGPAVRNYPAnVLTEIIGTFVLVFglLAFSQNDLAAGINPM 168
Cdd:PLN00183 125 LYITAQTVGSVLATYVGVSVY----------GVKADLMTTKPAQGCSSA-FWVEFIATFIVMF--LAASLTSQPQSLGHL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488285932 169 LVGILVLGLGLSLGGPTGY---AINPARDLGPRLahqiipVKTKGDSDWAYSWVPIVGPILGASLAAVIYL 236
Cdd:PLN00183 192 SGFVIGIAIGLAVLITGPVsggSMNPARSLGPAI------VSWDFKDIWIYITAPTIGAVAGALMFHLLRL 256
PLN00026 PLN00026
aquaporin NIP; Provisional
 4-235 1.86e-12

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 65.27  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932   4 SMMTQLFGEFFGTMILVLLGDGVcAAVNLKKSKAfaSGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFE 83
Cdd:PLN00026  69 SLTRKLGAEFVGTFILIFAATAG-PIVNQKYDGA--ETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFP 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  84 WGMVLPYIVAQVLGGFIGGLVVWLAYLPhwniTEDKGAILGTFATGPAvrnypanVLTEIIGTFVLVFGLLAFSQNDLAA 163
Cdd:PLN00026 146 WKHVPAYIAAQVSASICASFALKGVFHP----FMSGGVTVPSVSTGQA-------FALEFIITFNLLFVVTAVATDTRAV 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488285932 164 G-INPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAhqiipvktkgDSDWAYSWVPIVGPILGASLAAVIY 235
Cdd:PLN00026 215 GeLAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVA----------AGNYRAIWIYLVAPTLGALAGAGTY 277
PLN00027 PLN00027
aquaporin TIP; Provisional
 10-235 5.04e-11

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 60.96  E-value: 5.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  10 FGEFFGTMILVLLGDGVCAAVNLKKSKAFA--SGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMV 87
Cdd:PLN00027  24 LAEFISTLIFVFAGEGSGMAFNKLTDNGSTtpAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNITLLRG 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  88 LPYIVAQVLGGFIGGLVVWLAylphwniteDKGAILGTFATGPAVRNYPANVLtEIIGTFVLVFGLLAFS---QNDLAAG 164
Cdd:PLN00027 104 ILYWIAQLLGSVVACLLLKFS---------TGGLETSAFSLSSGVGVWNAFVF-EIVMTFGLVYTVYATAvdpKKGDLGI 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488285932 165 INPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAhqiipvktkgDSDWAYSWVPIVGPILGASLAAVIY 235
Cdd:PLN00027 174 IAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVV----------SWTWTNHWVYWAGPLIGGGIAGLVY 234
PLN00166 PLN00166
aquaporin TIP2; Provisional
 12-235 2.01e-10

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 59.18  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  12 EFFGTMILVLLGDGVCAAVNLKKSKAF--ASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMVLP 89
Cdd:PLN00166  24 EFIATLLFVFAGVGSAIAFAKLTSDAAldPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITIITGFF 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  90 YIVAQVLGGFIGGLVVWLAY----LPHWNITEDKGAILGtfatgpavrnypanVLTEIIGTFVLVFGLLAFSQNDLAAG- 164
Cdd:PLN00166 104 YWIAQCLGSIVACLLLVFVTngesVPTHGVAAGLGAIEG--------------VVMEIVVTFALVYTVYATAADPKKGSl 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488285932 165 --INPMLVGILVLGLGLSLGGPTGYAINPARDLGPRLAhqiipvktkgDSDWAYSWVPIVGPILGASLAAVIY 235
Cdd:PLN00166 170 gtIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAVV----------SGDFSQIWIYWVGPLVGGALAGLIY 232
PLN00167 PLN00167
aquaporin TIP5; Provisional
 12-235 1.87e-06

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 47.59  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  12 EFFGTMILVL--LGDGVCAAVNLKKSKAFASGWVVIALGWGAAVTLAVYMSGYMSPAHLNPAVTVAMAITGNFEWGMVLP 89
Cdd:PLN00167  28 EFISTFFFVFaaVGSAMSSRKLMPDAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTAMF 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488285932  90 YIVAQVLGGFIGGLVVWLAYLphwnitedkGAILGTFATGPAVRNYPANVLtEIIGTFVLVFGLLAFS--QNDLAAGINP 167
Cdd:PLN00167 108 YWISQMLASVMACLFLKVTTV---------GQHVPTYKIAEEMTGFGASVL-EGVLTFGLVYTVYAAGdpRRGLLGAIGP 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488285932 168 MLVGILVLGLGLSLGGPTGYAINPARDLGPRLAHQIIpvktkgdSDWAYSWvpiVGPILGASLAAVIY 235
Cdd:PLN00167 178 LAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSF-------KNQAVYW---VGPLLGGAVAGLLY 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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