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Conserved domains on  [gi|488287876|ref|WP_002359084|]
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MULTISPECIES: PTS sugar transporter subunit IIA [Lactobacillales]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10006772)

PTS mannose/fructose/sorbose family sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane

CATH:  3.40.50.510
Gene Ontology:  GO:0009401|GO:0016310|GO:0016301|GO:0008643|GO:1902495
PubMed:  11532441|10393270
SCOP:  4000512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 6-127 3.69e-26

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


:

Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 94.82  E-value: 3.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488287876   6 IASHGDFSKGIKHSLEMIAGHSAAaVHTYSLYPGESAVDFFGELKKKAEQAP-EDEFILMGDLFGASVVTAMMGLTV-LE 83
Cdd:COG2893    3 IATHGPLAEGLLSSAEMILGEQEN-VEAVDLYPGDDPEDLREKLEEAIAELDsGDGVLILTDLFGGTPSNVAARLLAkHE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 488287876  84 NVIVFSGVNLNLALELMLAGSEKLTDEKIQVIIRNARQGIQRVH 127
Cdd:COG2893   82 NVEVIAGVNLPMLLEALTYREDLSLDELVEKALEAGREGIKSLS 125
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 6-127 3.69e-26

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 94.82  E-value: 3.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488287876   6 IASHGDFSKGIKHSLEMIAGHSAAaVHTYSLYPGESAVDFFGELKKKAEQAP-EDEFILMGDLFGASVVTAMMGLTV-LE 83
Cdd:COG2893    3 IATHGPLAEGLLSSAEMILGEQEN-VEAVDLYPGDDPEDLREKLEEAIAELDsGDGVLILTDLFGGTPSNVAARLLAkHE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 488287876  84 NVIVFSGVNLNLALELMLAGSEKLTDEKIQVIIRNARQGIQRVH 127
Cdd:COG2893   82 NVEVIAGVNLPMLLEALTYREDLSLDELVEKALEAGREGIKSLS 125
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 4-121 1.65e-17

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 72.64  E-value: 1.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488287876   4 FYIASHGDFSKGIKHSLEMIAGhSAAAVHTYSLYPGESAVDFFGELKKKAEQAP-EDEFILMGDLFGASVVTAMMGLTV- 81
Cdd:cd00006    3 IIIATHGGFASGLLNSAEMILG-EQENVEAIDFPPGESPDDLLEKIKAALAELDsGEGVLILTDLFGGSPNNAAARLSMe 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488287876  82 LENVIVFSGVNLNLALELMLAGSEKLTDEKIQVIIRNARQ 121
Cdd:cd00006   82 HPPVEVIAGVNLPMLLEAARARELGLSLDELVENALEAGR 121
EIIA-man pfam03610
PTS system fructose IIA component;
6-112 9.83e-10

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 52.25  E-value: 9.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488287876    6 IASHGDFSKGIKHSLEMIAGhSAAAVHTYSLYPGESAVDFFGELKKKAEQAP-EDEFILMGDLFGASVVTAM-MGLTVLE 83
Cdd:pfam03610   4 IVSHGELAEGLLELAEMMAG-EQENVIAVGGTPGESIGTSFEKIVEAIENLDsGDGVLVLVDLGGATPNNEAaLELLEKE 82

                          90       100
                  ....*....|....*....|....*....
gi 488287876   84 NVIVFSGVNLNLALELMLAGSEKLTDEKI 112
Cdd:pfam03610  83 RMEVITGVNLPMVEGAYAARVSASLGELV 111
 
Name Accession Description Interval E-value
ManX COG2893
Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and ...
 6-127 3.69e-26

Phosphotransferase system, mannose/fructose-specific component IIA [Carbohydrate transport and metabolism];


Pssm-ID: 442138 [Multi-domain]  Cd Length: 126  Bit Score: 94.82  E-value: 3.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488287876   6 IASHGDFSKGIKHSLEMIAGHSAAaVHTYSLYPGESAVDFFGELKKKAEQAP-EDEFILMGDLFGASVVTAMMGLTV-LE 83
Cdd:COG2893    3 IATHGPLAEGLLSSAEMILGEQEN-VEAVDLYPGDDPEDLREKLEEAIAELDsGDGVLILTDLFGGTPSNVAARLLAkHE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 488287876  84 NVIVFSGVNLNLALELMLAGSEKLTDEKIQVIIRNARQGIQRVH 127
Cdd:COG2893   82 NVEVIAGVNLPMLLEALTYREDLSLDELVEKALEAGREGIKSLS 125
PTS_IIA_man cd00006
PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 4-121 1.65e-17

PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation. IIA subunits receive phosphoryl groups from HPr and transfer them to IIB subunits, which in turn phosphorylate the substrate.


Pssm-ID: 237978 [Multi-domain]  Cd Length: 122  Bit Score: 72.64  E-value: 1.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488287876   4 FYIASHGDFSKGIKHSLEMIAGhSAAAVHTYSLYPGESAVDFFGELKKKAEQAP-EDEFILMGDLFGASVVTAMMGLTV- 81
Cdd:cd00006    3 IIIATHGGFASGLLNSAEMILG-EQENVEAIDFPPGESPDDLLEKIKAALAELDsGEGVLILTDLFGGSPNNAAARLSMe 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488287876  82 LENVIVFSGVNLNLALELMLAGSEKLTDEKIQVIIRNARQ 121
Cdd:cd00006   82 HPPVEVIAGVNLPMLLEAARARELGLSLDELVENALEAGR 121
EIIA-man pfam03610
PTS system fructose IIA component;
6-112 9.83e-10

PTS system fructose IIA component;


Pssm-ID: 427399 [Multi-domain]  Cd Length: 113  Bit Score: 52.25  E-value: 9.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488287876    6 IASHGDFSKGIKHSLEMIAGhSAAAVHTYSLYPGESAVDFFGELKKKAEQAP-EDEFILMGDLFGASVVTAM-MGLTVLE 83
Cdd:pfam03610   4 IVSHGELAEGLLELAEMMAG-EQENVIAVGGTPGESIGTSFEKIVEAIENLDsGDGVLVLVDLGGATPNNEAaLELLEKE 82

                          90       100
                  ....*....|....*....|....*....
gi 488287876   84 NVIVFSGVNLNLALELMLAGSEKLTDEKI 112
Cdd:pfam03610  83 RMEVITGVNLPMVEGAYAARVSASLGELV 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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