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Conserved domains on  [gi|488290003|ref|WP_002361211|]
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MULTISPECIES: response regulator transcription factor [Enterococcus]

Protein Classification

response regulator transcription factor( domain architecture ID 11450879)

response regulator transcription factor with a signal receiver (REC) domain and a LuxR family helix-turn-helix (HTH) domain that may be part of a two-component regulatory system; similar to Staphylococcus aureus response regulator VraR

CATH:  1.10.10.10
Gene Ontology:  GO:0000160|GO:0006355|GO:0003677
PubMed:  10966457
SCOP:  3001179

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-198 2.04e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 82.63  E-value: 2.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLrktktklvfls 80
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL----------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  81 gfdlaeyrdkaigigangfldkhiavdslienlkkisyedkkifpqtsrhdlkhnliTPREKEVLRILSQGVKQSAIASK 160
Cdd:COG2197   71 ---------------------------------------------------------TPREREVLRLLAEGLSNKEIAER 93

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 488290003 161 MNITDRTLRNYVYSINEKLETNSAIASVVKAIELGIIN 198
Cdd:COG2197   94 LGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
PRK11173 super family cl32652
two-component response regulator; Provisional
 40-102 6.78e-03

two-component response regulator; Provisional


The actual alignment was detected with superfamily member PRK11173:

Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 36.15  E-value: 6.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290003  40 EMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVFLSGFDlaEYRDKAIG--IGANGFLDK 102
Cdd:PRK11173  41 QILSENDINLVIMDINLPGKNGLLLARELREQANVALMFLTGRD--NEVDKILGleIGADDYITK 103
 
Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-198 2.04e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 82.63  E-value: 2.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLrktktklvfls 80
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL----------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  81 gfdlaeyrdkaigigangfldkhiavdslienlkkisyedkkifpqtsrhdlkhnliTPREKEVLRILSQGVKQSAIASK 160
Cdd:COG2197   71 ---------------------------------------------------------TPREREVLRLLAEGLSNKEIAER 93

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 488290003 161 MNITDRTLRNYVYSINEKLETNSAIASVVKAIELGIIN 198
Cdd:COG2197   94 LGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 3-111 3.61e-19

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 79.09  E-value: 3.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKT-KTKLVFLSG 81
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYpDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 488290003  82 FDLAEYRDKAIGIGANGFLDKHIAVDSLIE 111
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIE 110
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 3-196 4.35e-14

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 67.75  E-value: 4.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLElgeeVLRKTKTK-----LV 77
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLE----TLDKLREKslsgrIV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  78 FLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKK-------ISYEDKKIFPQTSRH-----DLKHNLITPREKEVL 145
Cdd:PRK10651  85 VFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQaaagemvLSEALTPVLAASLRAnrattERDVNQLTPRERDIL 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488290003 146 RILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIELGI 196
Cdd:PRK10651 165 KLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERI 215
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-111 2.29e-12

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 61.01  E-value: 2.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003    3 ILLVDDHKLIGKSLEMTLKNYA-DVKEFryiSDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTK-TKLVFLS 80
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGyVVAEA---DDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPtTPVIILT 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 488290003   81 GFDLAEYRDKAIGIGANGFLDKHIAVDSLIE 111
Cdd:pfam00072  78 AHGDEDDAVEALEAGADDFLSKPFDPDELLA 108
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 138-191 1.79e-09

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 51.76  E-value: 1.79e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 488290003   138 TPREKEVLRILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKA 191
Cdd:smart00421   5 TPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
PRK11173 PRK11173
two-component response regulator; Provisional
 40-102 6.78e-03

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 36.15  E-value: 6.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290003  40 EMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVFLSGFDlaEYRDKAIG--IGANGFLDK 102
Cdd:PRK11173  41 QILSENDINLVIMDINLPGKNGLLLARELREQANVALMFLTGRD--NEVDKILGleIGADDYITK 103
 
Name Accession Description Interval E-value
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-198 2.04e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 82.63  E-value: 2.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLrktktklvfls 80
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRLL----------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  81 gfdlaeyrdkaigigangfldkhiavdslienlkkisyedkkifpqtsrhdlkhnliTPREKEVLRILSQGVKQSAIASK 160
Cdd:COG2197   71 ---------------------------------------------------------TPREREVLRLLAEGLSNKEIAER 93

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 488290003 161 MNITDRTLRNYVYSINEKLETNSAIASVVKAIELGIIN 198
Cdd:COG2197   94 LGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 3-111 3.61e-19

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 79.09  E-value: 3.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKT-KTKLVFLSG 81
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYpDLKVIVLTA 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 488290003  82 FDLAEYRDKAIGIGANGFLDKHIAVDSLIE 111
Cdd:cd17535   81 HDDPEYVLRALKAGAAGYLLKDSSPEELIE 110
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 2-102 1.23e-16

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 71.73  E-value: 1.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   2 KILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVL-RKTKTKLVFLS 80
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIReLDPDTKIIILS 80

                         90       100
                 ....*....|....*....|..
gi 488290003  81 GFDLAEYRDKAIGIGANGFLDK 102
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLK 102
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-116 5.62e-16

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 71.03  E-value: 5.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNY-ADVKEFryiSDPITVFEMIETYRPSIILMDIHM-GMfNGLELGEEV---LRKTKTK 75
Cdd:COG0784    6 KRILVVDDNPDNRELLRRLLERLgYEVTTA---EDGAEALELLRAGPPDLILLDINMpGM-DGLELLRRIralPRLPDIP 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 488290003  76 LVFLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:COG0784   82 IIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-110 1.82e-15

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 70.71  E-value: 1.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLK--NYadvkEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTK--- 75
Cdd:COG3706    2 ARILVVDDDPTNRKLLRRLLEaaGY----EVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTAdip 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 488290003  76 LVFLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLI 110
Cdd:COG3706   78 IIFLTALDDEEDRARALEAGADDYLTKPFDPEELL 112
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 3-116 3.50e-15

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 68.52  E-value: 3.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLK----NYADVKEFryiSDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRK-TKTKLV 77
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDweelGFEVVGEA---ENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELyPDIKII 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 488290003  78 FLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:cd17536   78 ILSGYDDFEYAQKAIRLGVVDYLLKPVDEEELEEALEKA 116
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 3-196 4.35e-14

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 67.75  E-value: 4.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLElgeeVLRKTKTK-----LV 77
Cdd:PRK10651   9 ILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLE----TLDKLREKslsgrIV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  78 FLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKK-------ISYEDKKIFPQTSRH-----DLKHNLITPREKEVL 145
Cdd:PRK10651  85 VFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQaaagemvLSEALTPVLAASLRAnrattERDVNQLTPRERDIL 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488290003 146 RILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIELGI 196
Cdd:PRK10651 165 KLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERI 215
PRK15369 PRK15369
two component system response regulator;
2-197 3.19e-13

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 65.49  E-value: 3.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   2 KILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRK-TKTKLVFLS 80
Cdd:PRK15369   5 KILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRwPAMNILVLT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  81 GFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKISYEDKKIFPQTSRH---------DLKHNLITPREKEVLRILSQG 151
Cdd:PRK15369  85 ARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREailallnadDTNPPLLTPRERQILKLITEG 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 488290003 152 VKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIELGII 197
Cdd:PRK15369 165 YTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-132 2.02e-12

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 61.91  E-value: 2.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVL-RKTKTKLVFL 79
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRaRGPDVDVIVI 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 488290003  80 SGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKISyEDKKIFPQTSRHDL 132
Cdd:COG4565   84 TAARDPETVREALRAGVVDYLIKPFTFERLREALERYL-EYRRLLREDQEEDL 135
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 3-111 2.29e-12

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 61.01  E-value: 2.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003    3 ILLVDDHKLIGKSLEMTLKNYA-DVKEFryiSDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTK-TKLVFLS 80
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGyVVAEA---DDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPtTPVIILT 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 488290003   81 GFDLAEYRDKAIGIGANGFLDKHIAVDSLIE 111
Cdd:pfam00072  78 AHGDEDDAVEALEAGADDFLSKPFDPDELLA 108
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-180 3.49e-12

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 62.67  E-value: 3.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNY-ADVKEFryiSDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEvLRKT--KTKLV 77
Cdd:COG0745    2 PRILVVEDDPDIRELLADALEREgYEVDTA---ADGEEALELLEEERPDLILLDLMLPGMDGLEVCRR-LRARpsDIPII 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  78 FLSGFDLAEYRDKAIGIGANGFLDK-------HIAVDSLIENLKKISYEDKKIFPQTSR---HDLKHNLITPREKEVLRI 147
Cdd:COG0745   78 MLTARDDEEDRVRGLEAGADDYLTKpfdpeelLARIRALLRRRAAEVLRVGDLLDLAARevtRDGEPVELTPKEFRLLEL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 488290003 148 LS----QGVKQSAIASKM----NITDRTLRNYVYSINEKLE 180
Cdd:COG0745  158 LMrnpgRVVSREQLLEEVwgydYGDDRTVDVHISRLRKKLE 198
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-115 4.99e-12

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 62.49  E-value: 4.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKN-YADVKEFRyisDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEvLRKTK----TK 75
Cdd:COG3437    7 PTVLIVDDDPENLELLRQLLRTlGYDVVTAE---SGEEALELLLEAPPDLILLDVRMPGMDGFELLRL-LRADPstrdIP 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488290003  76 LVFLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKK 115
Cdd:COG3437   83 VIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRN 122
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-116 1.46e-11

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 61.37  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEV-LRKTKTKLVFL 79
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLrELDPPPPIIFT 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 488290003  80 SGFDlaEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:COG3279   82 TAYD--EYALEAFEVNAVDYLLKPIDEERLAKALEKA 116
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 136-197 1.96e-11

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 57.66  E-value: 1.96e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488290003 136 LITPREKEVLRILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIELGII 197
Cdd:COG5905   12 LLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 3-195 3.67e-11

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 59.73  E-value: 3.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTL-------KNYADVKEFryisdpitvFEMIETYRPSIILMDIHM-GMfNGLELGEEvLRKTKT 74
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLesaglrvETFASAEAF---------LAALDPDRPGCLLLDVRMpGM-SGLELQEE-LAARGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  75 KL--VFLSGF-DLAEYRD--KAigiGANGFLDKHIAVDSLIENLKKISYEDKKIFPQTSRH-DLKHNL--ITPREKEVLR 146
Cdd:COG4566   71 PLpvIFLTGHgDVPMAVRamKA---GAVDFLEKPFDDQALLDAVRRALARDRARRAERARRaELRARLasLTPREREVLD 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488290003 147 ILSQGV--KQsaIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIELG 195
Cdd:COG4566  148 LVVAGLsnKQ--IARELGISPRTVEVHRANVMEKLGARSLAELVRLALALG 196
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-116 3.68e-11

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 61.13  E-value: 3.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNY-ADVKEFryiSDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTK-TKLVF 78
Cdd:COG2204    3 ARILVVDDDPDIRRLLKELLERAgYEVETA---ASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPdLPVIL 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 488290003  79 LSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:COG2204   80 LTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERA 117
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 4-102 5.11e-11

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 56.85  E-value: 5.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   4 LLVDDHKLIGKSLEMTLKNY-ADVKEFryiSDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTK-TKLVFLSG 81
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREgYEVDTA---ADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPdIPVIVLTA 77

                         90       100
                 ....*....|....*....|.
gi 488290003  82 FDLAEYRDKAIGIGANGFLDK 102
Cdd:cd00156   78 KADEEDAVRALELGADDYLVK 98
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
2-189 6.85e-11

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 59.10  E-value: 6.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   2 KILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKT-KLVFLS 80
Cdd:PRK10403   8 QVLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTaQIIILT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  81 GFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKiSYEDKKIFPQTSRHDLKH-----------NLITPREKEVLRILS 149
Cdd:PRK10403  88 VSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRA-GAKGSKVFSERVNQYLREremfgaeedpfSVLTERELDVLHELA 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 488290003 150 QGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVV 189
Cdd:PRK10403 167 QGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAATI 206
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-117 9.03e-11

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 56.78  E-value: 9.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVL-RKTKTKLVFLSG 81
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSkLAKPPLIVFVTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488290003  82 FDlaEYRDKAIGIGANGFLDKHIAVDSLIENLKKIS 117
Cdd:cd17532   81 YD--EYAVEAFELNAVDYLLKPFSEERLAEALAKLR 114
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
124-197 2.54e-10

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 57.46  E-value: 2.54e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488290003 124 FPQTSRHDLKHNLITPREKEVLRILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIELGII 197
Cdd:COG2771  115 LAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRLGLI 188
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 138-191 1.79e-09

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 51.76  E-value: 1.79e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 488290003   138 TPREKEVLRILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKA 191
Cdd:smart00421   5 TPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 1-102 2.07e-09

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 53.18  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKN--YadvkefrYISDPIT----VFEMIETYRPSIILMDIHM-GMFNGLELGEEVLRKTK 73
Cdd:cd17534    1 KKILIVEDEAIIALDLKEILESlgY-------EVVGIADsgeeAIELAEENKPDLILMDINLkGDMDGIEAAREIREKFD 73

                         90       100
                 ....*....|....*....|....*....
gi 488290003  74 TKLVFLSGFDLAEYRDKAIGIGANGFLDK 102
Cdd:cd17534   74 IPVIFLTAYSDEETLERAKETNPYGYLVK 102
PRK09483 PRK09483
response regulator; Provisional
 1-198 2.19e-09

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 55.11  E-value: 2.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKnyaDVKEFRYISDPITVFEMIETYR---PSIILMDIHMGMFNGLELGEEVLR-KTKTKL 76
Cdd:PRK09483   2 INVLLVDDHELVRAGIRRILE---DIKGIKVVGEACCGEDAVKWCRtnaVDVVLMDMNMPGIGGLEATRKILRyTPDVKI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  77 VFLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKIS----YEDKKIFPQTSRHDLKHNLITP------REKEVLR 146
Cdd:PRK09483  79 IMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHsgqrYIASDIAQQMALSQIEPATENPfaslseRELQIML 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488290003 147 ILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIELGIIN 198
Cdd:PRK09483 159 MITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLLN 210
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
3-193 2.32e-09

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 54.88  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLR-KTKTKLVFLSG 81
Cdd:PRK09935   6 VIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQiQSTVKVLFLSS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  82 FDLAEYRDKAIGIGANGFLDKHIAVDSlIENLKKISYEDKKIFPQTSRHDLKHN----------LITPREKEVLRILSQG 151
Cdd:PRK09935  86 KSECFYAGRAIQAGANGFVSKCNDQND-IFHAVQMILSGYTFFPSETLNYIKSNkcstnsstdtVLSNREVTILRYLVSG 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 488290003 152 VKQSAIASKMNITDRTLRNYVYSINEKLetnsAIASVVKAIE 193
Cdd:PRK09935 165 LSNKEIADQLLLSNKTVSAHKSNIYGKL----GLHSIVELID 202
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-113 4.58e-09

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 53.81  E-value: 4.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKN--YADVKEfryISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVF 78
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLREagYEVVAE---AADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVIL 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 488290003  79 LSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENL 113
Cdd:COG3707   81 LTAYSDPELIERALEAGVSAYLVKPLDPEDLLPAL 115
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-185 5.66e-09

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 53.75  E-value: 5.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNyADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEvLRKTKTK--LVF 78
Cdd:PRK09958   1 MNAIIIDDHPLAIAAIRNLLIK-NDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLET-LRKRQYSgiIII 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  79 LSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKIS--------YEDKKIFPQTSRHDlKHNLITPREKEVLRILSQ 150
Cdd:PRK09958  79 VSAKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKngycyfpfSLNRFVGSLTSDQQ-KLDSLSKQEISVMRYILD 157

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 488290003 151 GVKQSAIASKMNITDRTLRNYVYSINEKLETNSAI 185
Cdd:PRK09958 158 GKDNNDIAEKMFISNKTVSTYKSRLMEKLECKSLM 192
PRK10360 PRK10360
transcriptional regulator UhpA;
1-185 8.75e-09

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 53.06  E-value: 8.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNYAD---VKEFRYISDPITvfeMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTklV 77
Cdd:PRK10360   2 ITVALIDDHLIVRSGFAQLLGLEPDlqvVAEFGSGREALA---GLPGRGVQVCICDISMPDISGLELLSQLPKGMAT--I 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  78 FLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKISYEDKKIFPQTSrHDL---KHNLITPREKEVLRILSQGVKQ 154
Cdd:PRK10360  77 MLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIA-IKLasgRQDPLTKRERQVAEKLAQGMAV 155

                        170       180       190
                 ....*....|....*....|....*....|.
gi 488290003 155 SAIASKMNITDRTLRNYVYSINEKLETNSAI 185
Cdd:PRK10360 156 KEIAAELGLSPKTVHVHRANLMEKLGVSNDV 186
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 138-193 2.26e-08

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 48.68  E-value: 2.26e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 488290003 138 TPREKEVLRILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIE 193
Cdd:cd06170    2 TPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 1-110 2.74e-08

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 50.10  E-value: 2.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKN--YADVKEfryISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVF 78
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEagYEVVGE---ASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVL 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 488290003  79 LSGFDLAEYRDKAIGIGANGFLDKHIAVDSLI 110
Cdd:cd19932   78 LTAYSQQDLVERAKEAGAMAYLVKPFSESDLI 109
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 3-111 5.85e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 49.00  E-value: 5.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNY-ADVKEFryiSDPITVFEMIETYRPSIILMDIHM-GMfNGLE----LGEEVLRKTKTKL 76
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLgYEVDVA---ENGQEALELLKEEPFDLVLMDLQMpVM-DGLEatrrIRELEGGGRRTPI 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 488290003  77 VFLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIE 111
Cdd:cd17546   77 IALTANALEEDREKCLEAGMDDYLSKPVKLDQLKE 111
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 3-105 7.38e-08

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 48.99  E-value: 7.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNY-ADVKEFryiSDPITVFEMIETYRPSIILMDIHM-GMfNGLELGEEVLRK---TKTKLV 77
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEgAEVTTA---HSGEEALEAAQRFRPDVILSDIGMpGM-DGYELARRLRELpwlANTPAI 76

                         90       100
                 ....*....|....*....|....*...
gi 488290003  78 FLSGFDLAEYRDKAIgigANGFlDKHIA 105
Cdd:cd17580   77 ALTGYGQPEDRERAL---EAGF-DAHLV 100
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 3-121 1.71e-07

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 48.17  E-value: 1.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVkEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTK---LVFL 79
Cdd:cd17575    3 VLLVDDQAIIGEAVRRALADEEDI-DFHYCSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANPATRdipIIVL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 488290003  80 SGFDLAEYRDKAIGIGANGFLDKhiaVDSLIENLKKISYEDK 121
Cdd:cd17575   82 STKEEPEVKSEAFALGANDYLVK---LPDKIELVARIRYHSR 120
GerE pfam00196
Bacterial regulatory proteins, luxR family;
138-191 2.27e-07

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 46.04  E-value: 2.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488290003  138 TPREKEVLRILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKA 191
Cdd:pfam00196   4 SPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 2-115 3.04e-07

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 47.15  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   2 KILLVDDHKLIGKSLEMTLKNYA-DVKEfryISDPITVFEMIETYRPSIILMDIHM-GMfNGLelgeEVLRKTK------ 73
Cdd:cd17548    1 KILIVEDNPLNMKLARDLLESAGyEVLE---AADGEEALEIARKEKPDLILMDIQLpGM-DGL----EATRLLKedpatr 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 488290003  74 -TKLVFLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKK 115
Cdd:cd17548   73 dIPVIALTAYAMKGDREKILEAGCDGYISKPIDTREFLETVAK 115
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 3-116 3.36e-07

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 47.27  E-value: 3.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVL-RKTKTKLVFLSG 81
Cdd:cd19930    1 VLIAEDQEMVRGALAALLELEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELReELPDTKVLIVTT 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 488290003  82 FDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:cd19930   81 FGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTV 115
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 2-104 5.25e-07

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 46.34  E-value: 5.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   2 KILLVDDHKLIGKSLEMTLKN--YadvkEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLelgeEVLRKTK----TK 75
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAegY----EVLTADSGQEALALAEEELPDLILLDVMMPGMDGF----EVCRRLKedpeTR 72

                         90       100       110
                 ....*....|....*....|....*....|..
gi 488290003  76 L---VFLSGFDLAEYRDKAIGIGANGFLDKHI 104
Cdd:cd17538   73 HipvIMITALDDREDRIRGLEAGADDFLSKPI 104
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 3-116 9.09e-07

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 45.74  E-value: 9.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYAdvKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVFLSGF 82
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWG--YEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISNVPIIFISSR 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 488290003  83 DLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:cd18159   79 DDNMDQVMAINMGGDDYITKPFDLDVLLAKIKAI 112
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 3-116 1.07e-06

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 45.80  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLelgeEVLRKTK-----TKLV 77
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIELDPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGL----DTLKALReegvsARIV 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 488290003  78 FLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:cd19931   77 ILTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQA 115
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 1-102 1.33e-06

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 45.51  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKN--YADVKEFryiSDPITVFEMIETYRPSIILMDIHM-GMfNGLELGEEvLRKTKTK-- 75
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALLRSagYLEVVSF---TDPREALAWCRENPPDLILLDYMMpGM-DGLEFIRR-LRALPGLed 75

                         90       100
                 ....*....|....*....|....*....
gi 488290003  76 --LVFLSGFDLAEYRDKAIGIGANGFLDK 102
Cdd:cd17551   76 vpIVMITADTDREVRLRALEAGATDFLTK 104
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 1-116 1.66e-06

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 45.35  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLknyadVKEFRYI----SDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTK-TK 75
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDIL-----TKAGYEVvgeaANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPnAK 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 488290003  76 LVFLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:cd17542   76 VIMCSAMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 1-56 3.11e-06

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 42.94  E-value: 3.11e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 488290003     1 MKILLVDDHKLIGKSLEMTLKN-YADVKEFryiSDPITVFEMIETYRPSIILMDIHM 56
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKeGYEVDEA---TDGEEALELLKEEKPDLILLDIMM 54
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 1-102 3.53e-06

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 44.30  E-value: 3.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLknyADVKEFRYI---SDPITVFEMIETYRPSIILMDIHM-GMfNGLELGEEVLRKTKTKL 76
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRIL---ESDPDIEVVgtaRDGEEALEKIKELKPDVITLDIEMpVM-DGLEALRRIMAERPTPV 76

                         90       100
                 ....*....|....*....|....*...
gi 488290003  77 VFLSGFDLAEYRD--KAIGIGANGFLDK 102
Cdd:cd17541   77 VMVSSLTEEGAEItlEALELGAVDFIAK 104
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 3-114 2.02e-05

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 42.41  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYADVKEFRYisDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVFLSGF 82
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAY--DGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTSNVPIIMLTAK 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 488290003  83 DlaEYRDKAIG--IGANGFLDKHIAVDSLIENLK 114
Cdd:cd17614   79 D--SEVDKVLGleLGADDYVTKPFSNRELLARVK 110
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 2-102 3.95e-05

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 41.33  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   2 KILLVDDHKLIGKSLEMTLK--NYAdVKEFryiSDPITVFEMIETYRP-SIILMDIHMGMFNGLELGEEVlRKTK--TKL 76
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKkaGYA-VTEA---ESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREA-RKIDpdVKI 75

                         90       100
                 ....*....|....*....|....*.
gi 488290003  77 VFLSGFDLAEYRDKAIGIGANGFLDK 102
Cdd:cd18160   76 LFISGGAAAAPELLSDAVGDNATLKK 101
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 3-114 6.31e-05

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 40.83  E-value: 6.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLE--MTLKNYadvkEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEvLRKTKTKL--VF 78
Cdd:cd17627    1 ILVVDDDRAVRESLRrsLRFEGY----EVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRR-LRAAGNDLpiLV 75

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 488290003  79 LSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLK 114
Cdd:cd17627   76 LTARDSVSDRVAGLDAGADDYLVKPFALEELLARVR 111
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
146-197 8.37e-05

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 41.61  E-value: 8.37e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 488290003 146 RILSQGVKQSAIASKMNITDRTLRNYVYSINEKLETNSAIASVVKAIELGII 197
Cdd:COG2909  132 RLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLL 183
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 3-102 2.27e-04

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 38.97  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKnyADVKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVFLSGF 82
Cdd:cd19936    1 IALVDDDRNILTSVSMALE--AEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKSTLPVIFLTSK 78

                         90       100
                 ....*....|....*....|..
gi 488290003  83 DlaEYRDKAIGI--GANGFLDK 102
Cdd:cd19936   79 D--DEIDEVFGLrmGADDYITK 98
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 1-116 3.08e-04

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 38.74  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKN--YADVKEfryiSDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVL-RKTKTKLV 77
Cdd:cd17554    1 KKILVVDDEENIRELYKEELEDegYEVVTA----GNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIReKKPDLPVI 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 488290003  78 FLSGFDlaEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:cd17554   77 ICTAYS--EYKSDFSSWAADAYVVKSSDLTELKETIKRL 113
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 4-102 4.61e-04

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 38.16  E-value: 4.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   4 LLVDDHKLIGKSLEMTLKN--YaDVKEFryiSDPITVFEMIETYRPSIILMDIHM-GMfNGLELGEEvLRKTK--TKLVF 78
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKegY-EVDTA---ADGEEALELAREEQPDLIILDVMLpGM-DGFEVCRR-LREKGsdIPIIM 74

                         90       100
                 ....*....|....*....|....
gi 488290003  79 LSGFDLAEYRDKAIGIGANGFLDK 102
Cdd:cd17574   75 LTAKDEEEDKVLGLELGADDYITK 98
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-72 6.13e-04

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 39.86  E-value: 6.13e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290003   1 MKILLVDDHKLIGKSLEMTLknyADVKEFRYI---SDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKT 72
Cdd:PRK12555   1 MRIGIVNDSPLAVEALRRAL---ARDPDHEVVwvaTDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAER 72
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 2-116 6.83e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 38.05  E-value: 6.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   2 KILLVDDHKLIGKSLEMTLKN--YaDVKEfryISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEvLRKT----KTK 75
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGagY-EVVE---AADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKE-LRKLpaykFTP 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 488290003  76 LVFLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:cd17562   77 ILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKV 117
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 3-102 1.16e-03

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 36.96  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTL--KNYADVKefryISDPITVFEMIETYRPSIILMDIHMGMFNGLELGeEVLRKTK----TKL 76
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLekQGFRVVV----IDDPLRALTTLLNSKPDLILIDIDMPDLDGYELC-SLLRKSSalkdTPI 75

                         90       100
                 ....*....|....*....|....*.
gi 488290003  77 VFLSGFDLAEYRDKAIGIGANGFLDK 102
Cdd:cd17602   76 IMLTGKDGLVDRIRAKMAGASGYLTK 101
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 3-116 2.52e-03

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 36.23  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYAdvkefrYISDPITV----FEMIETYRPSIILMDIHMGMFNGLELGEEV-LRKTKTKLV 77
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEG------FNVYTTDLgeegLDLGKLYDYDIILLDLNLPDMSGYEVLRTLrLAKVKTPIL 74

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 488290003  78 FLSGFDLAEYRDKAIGIGANGFLDKHIAVDSLIENLKKI 116
Cdd:cd17616   75 ILSGLADIEDKVKGLGFGADDYMTKPFHKDELVARIHAI 113
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 3-99 3.10e-03

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 35.79  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLKNYA-DVKEFRYISDPITVFEmiETYRPSIILMDIHM-GMFNGLELGEEVL-RKTKTKLVFL 79
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGyTVLEAASGDEALDLLE--SGPDIDLLVTDVIMpGGMNGSQLAEEARrRRPDLKVLLT 78

                         90       100
                 ....*....|....*....|
gi 488290003  80 SGFDLaeyRDKAIGIGANGF 99
Cdd:cd18161   79 SGYAE---NAIEGGDLAPGV 95
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
33-80 3.50e-03

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 37.44  E-value: 3.50e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 488290003  33 SDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVFLS 80
Cdd:PRK00742  36 PDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRPTPVVMVS 83
orf27 CHL00148
Ycf27; Reviewed
 1-102 3.94e-03

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 37.00  E-value: 3.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLE--MTLKNYadvkEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVF 78
Cdd:CHL00148   7 EKILVVDDEAYIRKILEtrLSIIGY----EVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKESDVPIIM 82

                         90       100
                 ....*....|....*....|....
gi 488290003  79 LSGFDLAEYRDKAIGIGANGFLDK 102
Cdd:CHL00148  83 LTALGDVSDRITGLELGADDYVVK 106
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 3-115 5.19e-03

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 35.54  E-value: 5.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   3 ILLVDDHKLIGKSLEMTLkNYAD--VKEFryiSDPITVFEMIETYRPSIILMDIHM-GMfNGLELGEEVlRKTKTKL--V 77
Cdd:cd17549    1 VLLVDDDADVREALQQTL-ELAGfrVRAF---ADAEEALAALSPDFPGVVISDIRMpGM-DGLELLAQI-RELDPDLpvI 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 488290003  78 FLSGF---DLAEyrdKAIGIGANGFLDKHIAVDSLIENLKK 115
Cdd:cd17549   75 LITGHgdvPMAV---EAMRAGAYDFLEKPFDPERLLDVVRR 112
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
2-109 5.80e-03

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 36.75  E-value: 5.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   2 KILLVDDHKLIGKSLEMTLKNYAdvKEFRYISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVL-RKTKTKLVFLS 80
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFALQG--FETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRsHETRTPVILMT 83

                         90       100
                 ....*....|....*....|....*....
gi 488290003  81 GFDLAEYRDKAIGIGANGFLDKHIAVDSL 109
Cdd:PRK11361  84 AYAEVETAVEALRCGAFDYVIKPFDLDEL 112
PRK15479 PRK15479
transcriptional regulator TctD;
1-150 6.55e-03

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 36.24  E-value: 6.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003   1 MKILLVDDHKLIGKSLEMTLKNYA---DVkefryISDPITVFEMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLV 77
Cdd:PRK15479   1 MRLLLAEDNRELAHWLEKALVQNGfavDC-----VFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290003  78 FL--SGFDLAEyRDKAIGIGANGFLDKHIAVDSLIENLKKISYEDKKIFPQTSR------HDLKHNL-------ITPREK 142
Cdd:PRK15479  76 LLltARSAVAD-RVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQlgelifHDEGYFLlqgqplaLTPREQ 154


                 ....*...
gi 488290003 143 EVLRILSQ 150
Cdd:PRK15479 155 ALLTVLMY 162
PRK11173 PRK11173
two-component response regulator; Provisional
 40-102 6.78e-03

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 36.15  E-value: 6.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290003  40 EMIETYRPSIILMDIHMGMFNGLELGEEVLRKTKTKLVFLSGFDlaEYRDKAIG--IGANGFLDK 102
Cdd:PRK11173  41 QILSENDINLVIMDINLPGKNGLLLARELREQANVALMFLTGRD--NEVDKILGleIGADDYITK 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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