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Conserved domains on  [gi|488290844|ref|WP_002362052|]
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MULTISPECIES: acetate/propionate family kinase [Enterococcus]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.-
Gene Ontology:  GO:0016774|GO:0016310|GO:0000287|GO:0005524|GO:0006082|GO:0016301
PubMed:  7883769|23031654|16678422|9484901

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
2-394 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 689.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   2 SKTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILGSY 81
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIIKDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  82 DEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYLY 161
Cdd:COG0282   81 DEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 162 SVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTRS 241
Cdd:COG0282  161 ALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 242 GDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTVM 319
Cdd:COG0282  241 GDIDPGVVLYLMRKEGLS-ADEVDDLLNKESGLLGLS-GISSDMRDLEEAAASgdERARLALDMFVYRIKKYIGAYAAAL 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290844 320 NGVDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVHGEEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:COG0282  319 GGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRL 393
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
2-394 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 689.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   2 SKTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILGSY 81
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIIKDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  82 DEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYLY 161
Cdd:COG0282   81 DEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 162 SVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTRS 241
Cdd:COG0282  161 ALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 242 GDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTVM 319
Cdd:COG0282  241 GDIDPGVVLYLMRKEGLS-ADEVDDLLNKESGLLGLS-GISSDMRDLEEAAASgdERARLALDMFVYRIKKYIGAYAAAL 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290844 320 NGVDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVHGEEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:COG0282  319 GGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRL 393
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-394 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 686.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   3 KTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLID--LNILGS 80
Cdd:PRK00180   2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDgkLGLIKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  81 YDEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYL 160
Cdd:PRK00180  82 LDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 161 YSVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTR 240
Cdd:PRK00180 162 YALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 241 SGDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTV 318
Cdd:PRK00180 242 SGDIDPAIIPYLMEKLGMS-VDEIDNLLNKKSGLLGLS-GVSSDMRDIEAAAEEgdERAKLALDVFVYRLAKYIGSYAAA 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488290844 319 MNG-VDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNN--VHGEEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:PRK00180 320 LNGrLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRL 398
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 6-394 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 625.30  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   6 AINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILGSYDEIT 85
Cdd:cd24010    3 VINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGVSLDEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  86 GVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYLYSVPR 165
Cdd:cd24010   83 AVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYALPY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 166 EYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTRSGDVD 245
Cdd:cd24010  163 ELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGDID 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 246 ASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTVMNGVD 323
Cdd:cd24010  243 PAIVFYLMKKEGMS-VDEIERLLNKKSGLLGIS-GVSSDMRDIEEAAEEgdERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488290844 324 AIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVH-GEEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-389 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 536.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844    3 KTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILGSYD 82
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   83 EITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYLYS 162
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  163 VPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTRSG 242
Cdd:pfam00871 161 LPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  243 DVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLD--KPEVQTAYNIFIDRIRKYIGSYVTVMN 320
Cdd:pfam00871 241 DIDPAIIFYLAETLGMS-ADEINNTLNKKSGLLGLS-GVSSDLRYVEDAYAegKEDAQLAIKVYVHRLAKYIGSYAASLE 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488290844  321 GVDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVHGEEAVISTDDSKIKLLLVPTDEELMIAR 389
Cdd:pfam00871 319 RLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-394 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 523.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844    1 MSKTIAINAGSSSLKWQLYQMPN-EEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILG 79
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVNgEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   80 SYDEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKH--ILPEIISVAVFDTSFHTTMPEH 157
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKlfPLPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  158 NYLYSVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTM 237
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  238 GTRSGDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLD--KPEVQTAYNIFIDRIRKYIGSY 315
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGMS-ADDIENTLNKKSGLLGIS-GLSSDLRDIEDAYAegNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  316 VTVMNG-VDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNN--VHGEEAVISTDDSKIKLLLVPTDEELMIARDVE 392
Cdd:TIGR00016 321 IASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaaRSGKSGVISTPESKVKILVIPTNEELMIAQDAI 400


                  ..
gi 488290844  393 RL 394
Cdd:TIGR00016 401 RL 402
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
2-394 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 689.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   2 SKTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILGSY 81
Cdd:COG0282    1 MKILVLNAGSSSLKFQLFDMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIIKDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  82 DEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYLY 161
Cdd:COG0282   81 DEIDAVGHRVVHGGEKFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 162 SVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTRS 241
Cdd:COG0282  161 ALPYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 242 GDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTVM 319
Cdd:COG0282  241 GDIDPGVVLYLMRKEGLS-ADEVDDLLNKESGLLGLS-GISSDMRDLEEAAASgdERARLALDMFVYRIKKYIGAYAAAL 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290844 320 NGVDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVHGEEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:COG0282  319 GGLDALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANAARGGERVISTPDSRVKVLVIPTNEELMIARDTLRL 393
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-394 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 686.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   3 KTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLID--LNILGS 80
Cdd:PRK00180   2 KILVLNAGSSSLKFQLIDMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDgkLGLIKD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  81 YDEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYL 160
Cdd:PRK00180  82 LDEITAVGHRVVHGGEKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 161 YSVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTR 240
Cdd:PRK00180 162 YALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGKPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTR 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 241 SGDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTV 318
Cdd:PRK00180 242 SGDIDPAIIPYLMEKLGMS-VDEIDNLLNKKSGLLGLS-GVSSDMRDIEAAAEEgdERAKLALDVFVYRLAKYIGSYAAA 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488290844 319 MNG-VDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNN--VHGEEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:PRK00180 320 LNGrLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLaaRFGKEGDISTPDSKVKVLVIPTNEELMIARDTLRL 398
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 6-394 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 625.30  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   6 AINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILGSYDEIT 85
Cdd:cd24010    3 VINCGSSSLKFQLFDMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPELGVSLDEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  86 GVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYLYSVPR 165
Cdd:cd24010   83 AVGHRVVHGGEKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYALPY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 166 EYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTRSGDVD 245
Cdd:cd24010  163 ELYEKYGIRRYGFHGTSHRYVSRRAAELLGKPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGDID 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 246 ASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTVMNGVD 323
Cdd:cd24010  243 PAIVFYLMKKEGMS-VDEIERLLNKKSGLLGIS-GVSSDMRDIEEAAEEgdERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488290844 324 AIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVH-GEEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKAAgGGEREISTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 3-389 0e+00

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 536.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844    3 KTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILGSYD 82
Cdd:pfam00871   1 KVLVLNAGSSSIKFQLFDAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIIELLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   83 EITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYLYS 162
Cdd:pfam00871  81 EITLIGHRVVHGGEKFTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  163 VPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTRSG 242
Cdd:pfam00871 161 LPYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  243 DVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLD--KPEVQTAYNIFIDRIRKYIGSYVTVMN 320
Cdd:pfam00871 241 DIDPAIIFYLAETLGMS-ADEINNTLNKKSGLLGLS-GVSSDLRYVEDAYAegKEDAQLAIKVYVHRLAKYIGSYAASLE 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488290844  321 GVDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVHGEEAVISTDDSKIKLLLVPTDEELMIAR 389
Cdd:pfam00871 319 RLDAIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNNRFGKSGVISTEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-394 0e+00

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 523.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844    1 MSKTIAINAGSSSLKWQLYQMPN-EEVIAKGIVERIGLKDSIFTIKYGEGQKYEVIVDIDNHEVAVKMLLDQLIDLNILG 79
Cdd:TIGR00016   3 SMKILVLNAGSSSLKFALFDAVNgEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIIK 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   80 SYDEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKH--ILPEIISVAVFDTSFHTTMPEH 157
Cdd:TIGR00016  83 LLSEIDLIGHRVVHGGEKFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKlfPLPKAKNVAVFDTAFHQTMPEE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  158 NYLYSVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTM 237
Cdd:TIGR00016 163 AYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMM 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  238 GTRSGDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLD--KPEVQTAYNIFIDRIRKYIGSY 315
Cdd:TIGR00016 243 GTRSGDIDPAIIFYLAETLGMS-ADDIENTLNKKSGLLGIS-GLSSDLRDIEDAYAegNEQAKLAIKVYVHRIAKYIGSY 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  316 VTVMNG-VDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNN--VHGEEAVISTDDSKIKLLLVPTDEELMIARDVE 392
Cdd:TIGR00016 321 IASLEGnLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNaaRSGKSGVISTPESKVKILVIPTNEELMIAQDAI 400


                  ..
gi 488290844  393 RL 394
Cdd:TIGR00016 401 RL 402
PRK12397 PRK12397
acetate/propionate family kinase;
1-394 8.66e-169

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 477.80  E-value: 8.66e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   1 MS-KTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEgQKYEVIVDIDNHEVAVKMLLDQLIDLNILG 79
Cdd:PRK12397   1 MSyKIMAINAGSSSLKFQLLEMPQGDMLCQGLIERIGMADAQVTIKTHS-QKWQETVPVADHRDAVTLLLEKLLGYQIIN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  80 SYDEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNY 159
Cdd:PRK12397  80 SLRDIDGVGHRVAHGGEFFKDSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 160 LYSVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGT 239
Cdd:PRK12397 160 IYPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVPLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 240 RSGDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLD--KPEVQTAYNIFIDRIRKYIGSYVT 317
Cdd:PRK12397 240 RSGDIDPSILPWIAQREGKT-PQQLNQLLNNESGLLGVS-GVSSDYRDVEQAANtgNRQAKLALTLFAERIRATIGSYIM 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488290844 318 VMNGVDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVHgeEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:PRK12397 318 QMGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQRN--ATFIQTENALVKVAVINTNEELMIAQDVMRI 392
PRK07157 PRK07157
acetate kinase; Provisional
 1-394 3.79e-133

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 387.17  E-value: 3.79e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   1 MSKTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGeGQKYEVIVDIDNHEVAVKMLLDQLIDLNILGS 80
Cdd:PRK07157   2 KAKILVINAGSSSIKWQLFDKENLNLIASGLAERIGLENGLIKIKFG-KKKYEKEVDMPNHKVAVAVLIEIWEENKLIED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  81 YDEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYL 160
Cdd:PRK07157  81 LEEIELIGFRVVHGGDYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINYT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 161 YSVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRpiEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTR 240
Cdd:PRK07157 161 YPINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK--DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTR 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 241 SGDVDASLLPYLMTKLGLtDVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTV 318
Cdd:PRK07157 239 SGDIDPSIHEFVAKEANM-SISEFTDLLNKKSGLLGVS-GISSDLRDVIKAAESgnKRAKFALDLYAQKIVDYLANYINK 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 319 MNG-VDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNV----HGEEAVISTDDSKIKLLLVPTDEELMIARDVER 393
Cdd:PRK07157 317 IGKkIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLKkigeYGPIELISTPDSDIPVYVIRTNEELLIAKNAIK 396


                 .
gi 488290844 394 L 394
Cdd:PRK07157 397 L 397
PRK12379 PRK12379
propionate kinase;
7-394 7.58e-132

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 383.70  E-value: 7.58e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   7 INAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYGEgqkyEVIVDIDNHEVAVKMLLDQLIDLNILGSydeITG 86
Cdd:PRK12379  10 INCGSSSIKFSVLDASDCEVLMSGIADGINSENAFLSVNGGE----PAPLAHHSYEGALKAIAFELEKRNLNDS---VAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  87 VGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNYLYSVPRE 166
Cdd:PRK12379  83 IGHRIAHGGSIFTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLPWE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 167 YYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGTRSGDVDA 246
Cdd:PRK12379 163 YYEELGVRRYGFHGTSHRYVSQRAHSLLNLDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDF 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 247 SLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNLDK--PEVQTAYNIFIDRIRKYIGSYVTVMNGVDA 324
Cdd:PRK12379 243 GAMAWIASQTGQT-LGDLERVVNKESGLLGIS-GLSSDLRVLEKAWHEghERAQLAIKTFVHRIARHIAGHAASLHRLDG 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488290844 325 IVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNV--HGEEAVISTDDSKIKLLLVPTDEELMIARDVERL 394
Cdd:PRK12379 321 IIFTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQpnSGGERIISSENSRVICAVIPTNEEKMIALDAIHL 392
PRK12440 PRK12440
acetate/propionate family kinase;
2-389 1.35e-110

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 329.51  E-value: 1.35e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   2 SKTIAINAGSSSLKWQLYQMPNEEVIAKGIVERIGLKDSIFTIKYgEGQKYEV-IVDIDNHEvavKMLLDQLIDL-NILG 79
Cdd:PRK12440   4 SYVLVINSGSSSLKFAVIDSVTGEAVLSGLGECFGLEDARMSWKY-QGEKTEIaIEGEDNHH---KIAIGRLVGLtEELG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  80 SYDEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMPEHNY 159
Cdd:PRK12440  80 FTQDIVAVGHRIVHGGEKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 160 LYSVPREYYEKFAARKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGVTMGT 239
Cdd:PRK12440 160 TGAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKPIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 240 RSGDVDASLLPYLMTKlGLTDVQdMVDILNKKSGLLGLTnGLSSDMRDIQSNLDKPE--VQTAYNIFIDRIRKYIGSYVT 317
Cdd:PRK12440 240 RCGDLDPGIIEFLLKK-GWSQEK-VFNSLNKKSGFLGVS-GLTSDARGILEAMEEGHegATLAFEVFTYRVAKYIASYLA 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290844 318 VMNGVDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNV--HGEEAVISTDDS-KIKLLLVPTDEELMIAR 389
Cdd:PRK12440 317 ALDSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDarFGKAGIIAKSELlNAVAMVIPTNEEFVIAQ 391
PRK07058 PRK07058
acetate/propionate family kinase;
8-390 1.13e-97

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 296.58  E-value: 1.13e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   8 NAGSSSLKWQLYQMPNEEV--IAKGIverIGLKDSIFTIKYGEGQ-------KYEVIVDIdnHEVavkmlLDQLIDLniL 78
Cdd:PRK07058  10 NAGSSTVKIGLFEVDGNEArrIGKGD---IDFRRAPLRFHLRNGGetldiplKASVTDDL--HTV-----LDETFDW--L 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  79 GSY---DEITGVGHRVVAGGEEFKDSVVITDEVLEKIEALSELAPLHNPANAMGIKAFKHILPEIISVAVFDTSFHTTMP 155
Cdd:PRK07058  78 AAHfdvSELVAVGHRVVHGGDRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHRTQP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 156 EHNYLYSVPREYYEKfAARKYGAHGTSHRYVSQRAAEmLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMGFTPLAGV 235
Cdd:PRK07058 158 DLVRRFAIPRALHDE-GIKRYGFHGLSYKFVAGELRR-RAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLDGI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 236 TMGTRSGDVDASLLPYLMTKLGLTdVQDMVDILNKKSGLLGLTnGLSSDMRDIQSNlDKPEVQTAYNIFIDRIRKYIGSY 315
Cdd:PRK07058 236 PMATRCGALDPGVVLHLLKQEGMS-LDEVEDLLYHRSGLLGVS-GISGDTRDLLAS-DAPEAREALDLFALRIAGEIARL 312

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488290844 316 VTVMNGVDAIVFTAGIGENAVGVRKDIIDGMTWFGCEIDNDKNNVHGEeaVISTDDSKIKLLLVPTDEELMIARD 390
Cdd:PRK07058 313 AATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAANAF--TISSRTSRVAAFVIPTDEEQVIADE 385
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 174-331 7.60e-24

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 101.07  E-value: 7.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 174 RKYGAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKSVDTSMG------FTPlagvtmgTRSGDVDAS 247
Cdd:cd24011  147 RRSIFHALNQKAVARRAAKELGKPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAldgegpFSP-------ERAGTLPVG 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 248 LLPYLMTKLGLTdVQDMVDILNKKSGLLGLTNglSSDMRDIQSNLD--KPEVQTAYNIFIDRIRKYIGSYVTVMNG-VDA 324
Cdd:cd24011  220 DLIKLCFSGKYT-LEELKKKLKGKGGLVAYLG--TNDFREVEKRIEagDEKAKLVLDAMAYQIAKEIGALAAVLKGkVDA 296


                 ....*..
gi 488290844 325 IVFTAGI 331
Cdd:cd24011  297 IILTGGL 303
PRK03011 PRK03011
butyrate kinase; Provisional
 1-331 5.23e-19

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 87.52  E-value: 5.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844   1 MSKTIAINAGSSSLKWQLYqmPNEEVIAKGiveriglkdsifTIKYG--EGQKYEVIvdIDNHEVAVKMLLDQLIDLNI- 77
Cdd:PRK03011   1 MMRILVINPGSTSTKIAVF--EDEKPIFEE------------TLRHSaeELEKFKTI--IDQYEFRKQAILDFLKEHGId 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844  78 LGSYDEITGVGH--RVVAGGeefkdSVVITDEVLE--KIEALSE----LAPL--HNPANAMGIKAFkhIL-P----EIIS 142
Cdd:PRK03011  65 LSELDAVVGRGGllKPIPGG-----TYRVNEAMLEdlKNGKYGEhasnLGAIiaYEIAKELGIPAF--IVdPvvvdEMEP 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 143 VAVFdtsfhTTMPEhnylysVPREYYekfaarkygAHGTSHRYVSQRAAEMLGRPIEDLKIITCHLGNGASITAVDGGKS 222
Cdd:PRK03011 138 VARI-----SGLPE------IERKSI---------FHALNQKAVARRVAKELGKKYEELNLIVAHLGGGISVGAHRKGRV 197

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488290844 223 VDTSMG------FTPLagvtmgtRSGdvdaSLLPYLMTKL---GLTDVQDMVDILNKKSGLLGLTNglSSDMRDIQSNLD 293
Cdd:PRK03011 198 IDVNNAldgegpFSPE-------RAG----GLPVGDLVELcfsGKYTKEELKKKLVGKGGLVAYLG--TNDAREVEKRIE 264

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 488290844 294 K--PEVQTAYNIFIDRIRKYIGSYVTVMNG-VDAIVFTAGI 331
Cdd:PRK03011 265 EgdEKAKLVYEAMAYQIAKEIGAMAAVLKGkVDAIVLTGGL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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