|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
3-468 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 821.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 3 YTYADDSLTLHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEY 82
Cdd:PRK09243 2 LMYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLGIF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 83 PEDFLTYLANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGT 162
Cdd:PRK09243 82 DEDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 163 RRAQELDAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKT-HRDCVFLVDTYDTLKAG 241
Cdd:PRK09243 162 RRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETyPDNTVLLVDTYDTLKSG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 242 VPSAIRVAREMGDKINFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLIT 321
Cdd:PRK09243 242 VPNAIKVAKELGDGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVT 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 322 AYDQPALGAVFKLVSIEGEDGqMKDTIKLSSNAEKVTTPGKKQVWRITRKSDkKSEGDYVTLWNEDPrqEEEIYMFHPVH 401
Cdd:PRK09243 322 GSDAPALGGVYKLVAIEGEGG-MIPKIKLSNSPEKVTTPGRKQVYRIYDKGG-KAEADVITLADEEE--EEPLKMFHPVH 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488291059 402 TFINKYVRDFEARPVLQDIFVEGKRVYELPTLDEIKQYAKENLDSLWEEYKRDLNPQKYPVDLSTDC 468
Cdd:PRK09243 398 TYKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
7-475 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 656.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 7 DDSLTLHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEYPEDF 86
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGVFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 87 LTYLANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQ 166
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 167 ELDAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTHRD-CVFLVDTYDTLKaGVPSA 245
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYPDgTTLLVDTYDTLS-GVPNA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 246 IRVAREMGDKINFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLITAYDQ 325
Cdd:COG1488 240 IELAKELLARGGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 326 PALGAVFKLVSIEGeDGQMKDTIKLSSNAEKVTTPGKKQVWRitRKSDKKSEGDYVTLWNEDPrqeeeiymfhpvhtfin 405
Cdd:COG1488 320 PTLGFVYKLVAVEG-DGEWRPVIKLSETPGKKSKPGRKQVYR--RDEDGKATADLVALEDEPL----------------- 379
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 406 kyvrDFEARPVLQDIFVEGKRVYELPTLDEIKQYAKENLDSLWEEYKRDLNPQKYPVDLSTDCWNHKMNL 475
Cdd:COG1488 380 ----PGEPEPLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
11-465 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 640.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 11 TLHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEYPEDFLTYL 90
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGIFDDAFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 91 ANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQELDA 170
Cdd:TIGR01513 81 REFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 171 AIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTH-RDCVFLVDTYDTLKAGVPSAIRVA 249
Cdd:TIGR01513 161 ALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYpKATVLLVDTYDTLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 250 REMGDKINFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLITAYDQPALG 329
Cdd:TIGR01513 241 KELGEQGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 330 AVFKLVSIEGedgqmKDTIKLSSNAEKVTTPGKKQVWRITRkSDKKSEGDYVTLWNEDPRQEEEIYMFHPVHTFinkyvr 409
Cdd:TIGR01513 321 GVYKLVAYEG-----RPVMKLSENPEKSTLPGRKQVFRLYD-ATGKFLGDELTLADEPIEDLNQEKCTPVFAPV------ 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 488291059 410 dfeaRPVLQDIFVEGKRVYELPTLDEIKQYAKENLDSLWEEYKRDLNPQKYPVDLS 465
Cdd:TIGR01513 389 ----EPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLS 440
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
12-335 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 528.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 12 LHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEYPEDFLTYLA 91
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 92 NFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQELDAA 171
Cdd:cd01570 82 GFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 172 IWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTHRD-CVFLVDTYDTLKAGVPSAIRVAR 250
Cdd:cd01570 162 LSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDnFTLLVDTYDTLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 251 EMGDK-INFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLITAYDQPALG 329
Cdd:cd01570 242 ELGALgYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALG 321
|
....*.
gi 488291059 330 AVFKLV 335
Cdd:cd01570 322 GVYKLV 327
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
12-136 |
4.84e-48 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 161.91 E-value: 4.84e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 12 LHTDMYQINMMQTYWELGRaDLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEY-PEDFLTYL 90
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPYfKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 488291059 91 ANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVN 136
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09243 |
PRK09243 |
nicotinate phosphoribosyltransferase; Validated |
3-468 |
0e+00 |
|
nicotinate phosphoribosyltransferase; Validated
Pssm-ID: 236426 [Multi-domain] Cd Length: 464 Bit Score: 821.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 3 YTYADDSLTLHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEY 82
Cdd:PRK09243 2 LMYNDDSLALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRSLGIF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 83 PEDFLTYLANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGT 162
Cdd:PRK09243 82 DEDFLDYLRNFRFTGDVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAGGRPLLEFGS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 163 RRAQELDAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKT-HRDCVFLVDTYDTLKAG 241
Cdd:PRK09243 162 RRAQGPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQAFDDEYEAFRAYAETyPDNTVLLVDTYDTLKSG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 242 VPSAIRVAREMGDKINFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLIT 321
Cdd:PRK09243 242 VPNAIKVAKELGDGIELGGVRIDSGDLAYLSKKVRKMLDEAGFTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVT 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 322 AYDQPALGAVFKLVSIEGEDGqMKDTIKLSSNAEKVTTPGKKQVWRITRKSDkKSEGDYVTLWNEDPrqEEEIYMFHPVH 401
Cdd:PRK09243 322 GSDAPALGGVYKLVAIEGEGG-MIPKIKLSNSPEKVTTPGRKQVYRIYDKGG-KAEADVITLADEEE--EEPLKMFHPVH 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488291059 402 TFINKYVRDFEARPVLQDIFVEGKRVYELPTLDEIKQYAKENLDSLWEEYKRDLNPQKYPVDLSTDC 468
Cdd:PRK09243 398 TYKSKTVKNFDAEPLLVPVMENGKRVYELPSLEEIRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
|
|
| PncB |
COG1488 |
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ... |
7-475 |
0e+00 |
|
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis
Pssm-ID: 441097 [Multi-domain] Cd Length: 445 Bit Score: 656.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 7 DDSLTLHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEYPEDF 86
Cdd:COG1488 1 MDNLALLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSLGVFDEDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 87 LTYLANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQ 166
Cdd:COG1488 81 LDYLADFRFPGDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAGGRPLHDFGLRRAH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 167 ELDAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTHRD-CVFLVDTYDTLKaGVPSA 245
Cdd:COG1488 161 GLEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQAHDDELEAFRAFAEAYPDgTTLLVDTYDTLS-GVPNA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 246 IRVAREMGDKINFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLITAYDQ 325
Cdd:COG1488 240 IELAKELLARGGLLGIRLDSGDLAYLSKQARELLDEAGLPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 326 PALGAVFKLVSIEGeDGQMKDTIKLSSNAEKVTTPGKKQVWRitRKSDKKSEGDYVTLWNEDPrqeeeiymfhpvhtfin 405
Cdd:COG1488 320 PTLGFVYKLVAVEG-DGEWRPVIKLSETPGKKSKPGRKQVYR--RDEDGKATADLVALEDEPL----------------- 379
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 406 kyvrDFEARPVLQDIFVEGKRVYELPTLDEIKQYAKENLDSLWEEYKRDLNPQKYPVDLSTDCWNHKMNL 475
Cdd:COG1488 380 ----PGEPEPLLVPVFRDGKLVYELPSLEEIRERAAAQLAELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
|
|
| NAPRTase_put |
TIGR01513 |
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ... |
11-465 |
0e+00 |
|
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 273666 [Multi-domain] Cd Length: 443 Bit Score: 640.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 11 TLHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEYPEDFLTYL 90
Cdd:TIGR01513 1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASLGIFDDAFLDYL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 91 ANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQELDA 170
Cdd:TIGR01513 81 REFRFSGTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKPLLEFGLRRAQGPDA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 171 AIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTH-RDCVFLVDTYDTLKAGVPSAIRVA 249
Cdd:TIGR01513 161 ALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSFDNELAAFRAYAKLYpKATVLLVDTYDTLRSGLPNAIAVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 250 REMGDKINFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLITAYDQPALG 329
Cdd:TIGR01513 241 KELGEQGKVVGVRIDSGDLLYLSKQARKQLDAAGLTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 330 AVFKLVSIEGedgqmKDTIKLSSNAEKVTTPGKKQVWRITRkSDKKSEGDYVTLWNEDPRQEEEIYMFHPVHTFinkyvr 409
Cdd:TIGR01513 321 GVYKLVAYEG-----RPVMKLSENPEKSTLPGRKQVFRLYD-ATGKFLGDELTLADEPIEDLNQEKCTPVFAPV------ 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 488291059 410 dfeaRPVLQDIFVEGKRVYELPTLDEIKQYAKENLDSLWEEYKRDLNPQKYPVDLS 465
Cdd:TIGR01513 389 ----EPLLRLVMKNGQRVRPLPSLAEIRARAREQLSKLPPEYLRLLNPHVYPVSLS 440
|
|
| NAPRTase_A |
cd01570 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ... |
12-335 |
0e+00 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).
Pssm-ID: 238804 [Multi-domain] Cd Length: 327 Bit Score: 528.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 12 LHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEYPEDFLTYLA 91
Cdd:cd01570 2 LLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIFDEEFLDYLR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 92 NFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQELDAA 171
Cdd:cd01570 82 GFRFTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGGRPLLEFGLRRAQGPDAA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 172 IWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTHRD-CVFLVDTYDTLKAGVPSAIRVAR 250
Cdd:cd01570 162 LSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAFDDELAAFRAFAEAYPDnFTLLVDTYDTLRSGLPNAIAVAK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 251 EMGDK-INFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLITAYDQPALG 329
Cdd:cd01570 242 ELGALgYRLVGVRIDSGDLAYLSKEARKMLDEAGLTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALG 321
|
....*.
gi 488291059 330 AVFKLV 335
Cdd:cd01570 322 GVYKLV 327
|
|
| PRK12484 |
PRK12484 |
nicotinate phosphoribosyltransferase; Provisional |
7-480 |
6.85e-162 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 237112 [Multi-domain] Cd Length: 443 Bit Score: 465.76 E-value: 6.85e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 7 DDSLTLHTDMYQINMMQTYWELGRADlHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEYPEDF 86
Cdd:PRK12484 1 QRNLALLTDLYEVTMANAYLREGMSA-PATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQFSEEF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 87 LTYLANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQ 166
Cdd:PRK12484 80 LAWLAGLRFTGDVRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVLAAAGRPVVDFGARRAH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 167 ELDAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTHRD-CVFLVDTYDTLkAGVPSA 245
Cdd:PRK12484 160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAFPDEVAAFRAFARLYPDaTTLLVDTYDTL-RGVRNA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 246 IRVAREMGDKINFLGVRIDSGDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLITAYDQ 325
Cdd:PRK12484 239 IEVAKELGNRFDPRGVRLDSGDLAELSKATRAILDAAGLEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 326 PALGAVFKLVSIEGeDGQMKdtiklsSNAEKVTTPGKKQVWRITRKSDKKseGDYVTLWNEDPRQEEEiymfhpvhtfin 405
Cdd:PRK12484 319 PVLDSAYKLVAYEG-RGVTK------LSSGKVTYPGRKQVFRLYEHGTAC--GDVIGLHTENIPDGRE------------ 377
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488291059 406 kyvrdfearPVLQDIFVEGKRVYELPTLDEIKQYAKENLDSLWEEYKRDLNPQKYPVDLSTDCWNHKMNLLEKVR 480
Cdd:PRK12484 378 ---------PLLVPVMTNGRRIQHAPTLDGARDWCEAQLAALPPEARRLVDPVAVSVTLSGELARLRHADTAEAH 443
|
|
| PLN02885 |
PLN02885 |
nicotinate phosphoribosyltransferase |
12-465 |
3.66e-126 |
|
nicotinate phosphoribosyltransferase
Pssm-ID: 178473 [Multi-domain] Cd Length: 545 Bit Score: 378.23 E-value: 3.66e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 12 LHTDMYQINMMQTYWELGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVE-EYPED-FLTY 89
Cdd:PLN02885 13 LLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMpSGCEDaFFDY 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 90 LANFEfkCT---VRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDP-LLEFGTRRA 165
Cdd:PLN02885 93 LRGLD--CSdveVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKvLLEFGLRRA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 166 QELDAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSY---------------------------------- 211
Cdd:PLN02885 171 QGPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYmgldeivdktlrsadgssvcedfvslvqewlskl 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 212 ------------GNDYE--AFMAYAkthrdCVF------LVDTYDTLKAGVPSAIRVA---REMGDKInfLGVRIDSGDM 268
Cdd:PLN02885 251 qessslrgvfseTNQSElaAFTSYA-----LAFpnsflaLVDTYDVMKSGIPNFCAVAlalNDLGYKA--VGIRLDSGDL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 269 AYISKRVR-------EQLDEAGFTEAKIYASNDLDENTILNLKMQKSKIDVWGVGTKLITAYDQPALGAVFKLVSIEGEd 341
Cdd:PLN02885 324 AYLSLEARkffrtieEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQ- 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 342 gqmkDTIKLSSNAEKVTTPGKKQVWRITRKsdkksEG----DYVTLWNE-DPRQEEEIYMFHPvhtFI-NK--YVRDFEA 413
Cdd:PLN02885 403 ----PRIKLSEDVEKVTIPCKKRCYRLYGK-----EGyplvDLMTGENEpPPKVGERILCRHP---FNeSKraYVVPQRV 470
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 488291059 414 RPVLQDIF--VEGKRVYELPTLDEIKQYAKENLDSLWEEYKRDLNPQKYPVDLS 465
Cdd:PLN02885 471 EELLKCYWdgSSGKPREELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVS 524
|
|
| NAPRTase_PncB |
cd01567 |
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ... |
12-333 |
1.59e-118 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238801 [Multi-domain] Cd Length: 343 Bit Score: 351.57 E-value: 1.59e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 12 LHTDMYQINMMQTYWElGRADLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEYPEDFLTYLA 91
Cdd:cd01567 2 LDTDLYKLTMMQAYLY-PYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLIFGEFFLYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 92 NFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDD------------PLLE 159
Cdd:cd01567 81 LGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGGLletkdnleelgfKLHD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 160 FGTRRAQELDAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGND-YEAFMAYAKTHRD-----CVFLVD 233
Cdd:cd01567 161 FGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALeEAAFEAFARWLPQfggglGIALID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 234 TYDTLKaGVPSAIRVAREMGDKINFLGVRIDSGDMAYISKRVREQLDEAGF--TEAKIYASNDLD-ENTILNLKMQKSK- 309
Cdd:cd01567 241 TYDTDN-GFLNALKLAKALGAGGGLLGVRLDSGDPVELIKKVRKHLDELGIdlNKKKIIISGDLDtEEAIELLLEQGASp 319
|
330 340
....*....|....*....|....
gi 488291059 310 IDVWGVGTKLITAYDQPALGAVFK 333
Cdd:cd01567 320 NDAFGVGTSLTNDLGRPPLGFVYK 343
|
|
| PRTase_typeII |
cd00516 |
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ... |
15-333 |
3.12e-69 |
|
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.
Pssm-ID: 238286 [Multi-domain] Cd Length: 281 Bit Score: 222.50 E-value: 3.12e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 15 DMYQINMMQTYwelGRADLHAVFECYFREmpfnHGYAIFAGLERLVNYLENLTFtesdiaylreveeypEDFLTYLANFE 94
Cdd:cd00516 1 DLYKLTMIQAY---PPPDTRATAEFTARE----DPYGVLAGLEEALELLELLRF---------------PGPLVILAVPE 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 95 fkctvrsaleGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDD--PLLEFGTRRAQElDAAI 172
Cdd:cd00516 59 ----------GTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAKGAntKVHDFGTRKTTP-GLRL 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 173 WGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDyEAFMAYAKTHRD-CVFLVDTYDTLkagVPSAIRVARE 251
Cdd:cd00516 128 LEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAFGEL-AAVKALRRWLPElFIALIDVEVDT---LEEALEAAKA 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 252 MGdkinFLGVRIDSG-----DMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLKmqKSKIDVWGVGTKLITAydqP 326
Cdd:cd00516 204 GG----ADGIRLDSGspeelDPAVLILKARAHLDGKGLPRVKIEASGGLDEENIRAYA--ETGVDVFGVGTLLHSA---P 274
|
....*..
gi 488291059 327 ALGAVFK 333
Cdd:cd00516 275 PLDIVLK 281
|
|
| NAPRTase_B |
cd01571 |
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ... |
45-342 |
7.02e-50 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.
Pssm-ID: 238805 [Multi-domain] Cd Length: 302 Bit Score: 172.84 E-value: 7.02e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 45 PFNHGYAIFAGLERLVNYLENltftesdiaylreveeypedfltylanfeFKCTVRSALEGDLVFNNEPLIQIEGPLAQC 124
Cdd:cd01571 30 QRSLPWAVLCGLEEVLALLEG-----------------------------LPVKVYALPEGTIFNPKEPVLRIEGPYQDF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 125 QLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQELDAAIWGtRAAYIGGADATSNVRAGKIFGIPVSGTHA 204
Cdd:cd01571 81 GELETAILGILARASSIATNAARVKLAAGDKPVISFGDRRDHPAIQPMDG-RAAYIGGCDGVSTVLGAELLGEKPSGTMP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 205 HSLVQSYGNDY-EAFMAYAKTH---RDCVFLVDTYDTLKAGvpsAIRVAREMGDKINflGVRIDS-----GDMAYISKRV 275
Cdd:cd01571 160 HALIQIFGGDQvEAWKAFDETYpedVPRIALIDTFNDEKEE---ALKAAKALGDKLD--GVRLDTpssrrGVFRYLIREV 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488291059 276 REQLDEAGFTEAKIYASNDLDENTILNLKmqKSKIDVWGVGTKLITAydqPALGAVFKLVSIEGEDG 342
Cdd:cd01571 235 RWALDIRGYKHVKIFVSGGLDEEDIKELE--DVGVDAFGVGTAISKA---PPVDFTMDIVEVNGQPI 296
|
|
| PRK08662 |
PRK08662 |
nicotinate phosphoribosyltransferase; Reviewed |
14-317 |
1.43e-48 |
|
nicotinate phosphoribosyltransferase; Reviewed
Pssm-ID: 236328 [Multi-domain] Cd Length: 343 Bit Score: 170.44 E-value: 1.43e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 14 TDMYQINMMQTYWELGRaDLHAVFECYFREMPfNHGYAIFAGLERLVNYLENLtftesdiaylreveeypedfltylanf 93
Cdd:PRK08662 18 TDIYFERTVEILEHAGK-NPKVVAEVTASSLP-KGEWGVFAGLEEVLELLEGK--------------------------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 94 efKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRaqeLDAAIW 173
Cdd:PRK08662 69 --PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAGDKPVLSFGARH---VHPAIA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 174 GT--RAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYEAFMAYAKTHRDCV---FLVDTYdtlKAGVPSAIRV 248
Cdd:PRK08662 144 PMmdRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIFGDQVEAWKAFDEVVPPDVpriALVDTF---KDEREEALRA 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488291059 249 AREMGDKINflGVRIDS-----GDMAYISKRVREQLDEAGFTEAKIYASNDLDENTILNLkmqKSKIDVWGVGT 317
Cdd:PRK08662 221 AEALGDRLD--GVRLDTpssrrGNFRKIVREVRWTLDIRGYEHVKIFVSGGLDPERIREL---RDVVDGFGVGT 289
|
|
| NAPRTase_N |
pfam17767 |
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ... |
12-136 |
4.84e-48 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.
Pssm-ID: 465494 [Multi-domain] Cd Length: 125 Bit Score: 161.91 E-value: 4.84e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 12 LHTDMYQINMMQTYWELGRaDLHAVFECYFREMPFNHGYAIFAGLERLVNYLENLTFTESDIAYLREVEEY-PEDFLTYL 90
Cdd:pfam17767 1 LDTDLYKLTMAQAYFKNGP-DVQVVFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPYfKPDFLDYL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 488291059 91 ANFEFKCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVN 136
Cdd:pfam17767 80 RNFRFDPSIVAVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
|
|
| NAPRTase_C |
pfam17956 |
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ... |
362-470 |
2.07e-38 |
|
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.
Pssm-ID: 465585 [Multi-domain] Cd Length: 111 Bit Score: 135.77 E-value: 2.07e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 362 KKQVWRITRKsDKKSEGDYVTLWNED-PRQEEEIYMFHPVHTFINKYVRDFEARPVLQDIFVEGKRVYELPTLDEIKQYA 440
Cdd:pfam17956 1 RKQVYRLYDK-DGKAIADLITLADEPpPDPGEEILCFHPFDEWKRKTVTPFTVEPLLKPVFEDGKLVYELPTLEEIRAYV 79
|
90 100 110
....*....|....*....|....*....|
gi 488291059 441 KENLDSLWEEYKRDLNPQKYPVDLSTDCWN 470
Cdd:pfam17956 80 QEQLSRLWPEHKRLLNPHPYKVDLSEKLYQ 109
|
|
| PncB_like |
cd01401 |
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ... |
12-358 |
8.62e-24 |
|
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.
Pssm-ID: 238695 [Multi-domain] Cd Length: 377 Bit Score: 102.71 E-value: 8.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 12 LHTDMYQINMMQTYWELgRADLHAVFEcyFREMPFNHGYAIFAG-LERLVNYLENLTFTESDIAYLREVEEY-PEDFLTY 89
Cdd:cd01401 4 LDTDLYKLTMQQAVLHH-YPDVQVTYE--FTNRSPEDFLEEAAEaLREQIDHLANLRFSEEELAYLRRSLPFlKPDYLDY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 90 LANFEFK----CTVRSALEGDLvfnnepLIQIEGPLAQCQLVETALLNMVN---------------FQTLIATKAARIKS 150
Cdd:cd01401 81 LELFRLNpeevVVRLDTGKGQL------DIRISGPWKDTILYEVPLLAIVSevyfrfrdadwdyeeQLEKLEEKLERLLE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 151 VIGDDPL-----LEFGTRR-----AQE--LDAAIWGTRAAYIGgadaTSNVRAGKIFGIPVSGTHAH-------SLVQSY 211
Cdd:cd01401 155 EAKRRDLngfrfSDFGTRRrfsyeVQEtvLKGLKQAAPGYLTG----TSNVHFAMKYGLTPIGTVAHewfmahqALTGDL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 212 GN-DYEAFMAYAKTHRD--CVFLVDTYDT---LK-AGVPSAIRvaremgdkinFLGVRIDSGD-MAYISKRVR--EQLDE 281
Cdd:cd01401 231 KDsQKAALERWVREYGGdlGIALTDTFGTdafLRdFDLYFAKL----------FDGVRHDSGDpFEWGEKAIAhyEKLGI 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 282 AGFTEAKIYaSNDLDENTILNLKMQ-KSKIDV-WGVGTKL-----ITAYDQPaLGAVFKLVSIEGedgqmKDTIKLSSNA 354
Cdd:cd01401 301 DPKTKTLVF-SDGLDVEKALELYEYfKGRIKVsFGIGTNLtndfgNKEKSTP-LNIVIKLVECNG-----RPVAKISDSP 373
|
....
gi 488291059 355 EKVT 358
Cdd:cd01401 374 GKNM 377
|
|
| PRK05321 |
PRK05321 |
nicotinate phosphoribosyltransferase; Provisional |
9-360 |
1.06e-21 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235406 [Multi-domain] Cd Length: 400 Bit Score: 96.75 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 9 SLtLHTDMYQINMMQTYWELGRaDLHAVFEcyFRempfNHGYAIFAG-----LERLVNYLENLTFTESDIAYLREVEEYP 83
Cdd:PRK05321 11 SL-LDTDFYKLTMQQAVLHHYP-DAQVEYE--FI----CRNDEVDLAeyideIREQLDHLCTLRLTDDELDYLRGLPFFK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 84 EDFLTYLANFEF--KCTVRSALEGDLVfnneplIQIEGPLAQCQLVETALLNMVN---------------FQTLIATKAA 146
Cdd:PRK05321 83 PDFLDWLRLFRLnpYEVTVSIDDGQLD------IRIEGPWLETILWEVPLLAIISelyfrarspevlyaqAKRRLWEKIE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 147 RIKSVIGDDPLL--EFGTRR-----AQE--LDAAIWGTRAAYIGgadaTSNVRAGKIFGIPVSGTHAHSLVQSYG----- 212
Cdd:PRK05321 157 LLKALPDLSGFKiaDFGTRRrfsfeWQEevVEALKEGLPGAFVG----TSNVHLAMKLGLTPIGTMAHEWFMAHQalgpr 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 213 ---NDYEAFMAYAKTHRD--CVFLVDTYdTLKAgvpsairvaremgdkinFL------------GVRIDSGD-------- 267
Cdd:PRK05321 233 lrdSQYAALEDWVREYRGdlGIALTDTI-GMDA-----------------FLrdfdlyfaklfdGLRHDSGDpiewgeka 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 268 MA-YISKRV--REQLdeagfteakIYASNDLDENTILNLKMQ-KSKIDV-WGVGTKL---ITAYdqPALGAVFKLVSIEG 339
Cdd:PRK05321 295 IAhYEKLGIdpRTKT---------LVFSDGLDFDKALELYRHfKGRIKLsFGIGTNLtndFPGV--KPLNIVIKLVECNG 363
|
410 420
....*....|....*....|.
gi 488291059 340 edgqmKDTIKLSSNAEKVTTP 360
Cdd:PRK05321 364 -----RPVAKLSDSPGKTMCD 379
|
|
| PRK07188 |
PRK07188 |
nicotinate phosphoribosyltransferase; Provisional |
96-320 |
2.94e-19 |
|
nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 235953 [Multi-domain] Cd Length: 352 Bit Score: 88.85 E-value: 2.94e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 96 KCTVRSALEGDLVFNNEPLIQIEGPLAQCQLVETALLNMVNFQTLIATKAARIKSVIGDDPLLEFGTRRAQELDAAIWGt 175
Cdd:PRK07188 71 KLKIRYLKDGDIINPFETVLEIEGPYENFGFLEGIIDGILARRTSVATNAYNVVQAANEKPVIFMGDRADHYLQQAGDG- 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 176 RAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSY-GNDYEAFMAYAKT--HRDCVFLVD-TYDTLKAgvpsAIRVARE 251
Cdd:PRK07188 150 YAAYIGGISAFSTHAQNEWWGKSGFGTMPHALIQMFnGDVVEACKAYHKTfpEDELIALVDyNNDVITD----SLKVARE 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 252 MGDKINflGVRID-SGDMA---------------------YISKRVREQLDEAGFTEAKIYASNDLDENTILNLKMQKSK 309
Cdd:PRK07188 226 FGDKLK--GVRVDtSKNMIdkyfirhpevlgtfdprgvnpELIKALRKALDENGGKHVKIIVSSGFDAKKIREFEAQNVP 303
|
250
....*....|.
gi 488291059 310 IDVWGVGTKLI 320
Cdd:PRK07188 304 VDIYGVGSSLL 314
|
|
| NAPRTase |
TIGR01514 |
nicotinate phosphoribosyltransferase; This model represents nicotinate ... |
12-359 |
3.48e-17 |
|
nicotinate phosphoribosyltransferase; This model represents nicotinate phosphoribosyltransferase, the first enzyme in the salvage pathway of NAD biosynthesis from nicontinate (niacin). Members are primary proteobacterial but also include yeasts and Methanosarcina acetivorans. A related family, apparently non-overlapping in species distribution, is TIGR01513. Members of that family differ in substantially in sequence and have a long C-terminal extension missing from this family, but are proposed also to act as nicotinate phosphoribosyltransferase (see model TIGR01513). [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]
Pssm-ID: 130578 [Multi-domain] Cd Length: 394 Bit Score: 83.27 E-value: 3.48e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 12 LHTDMYQINMMQTYWELgRADLHAVFECYFR-EMPFNHGYAifAGLERLVNYLENLTFTESDIAYLR-EVEEYPEDFLTY 89
Cdd:TIGR01514 6 LDTDLYKITMHQAVFHN-FPDVHVTYEFICRsSQLFLKEAA--EALREEISALGNLRFTDDEIEYLKqELPYLKSDYIDY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 90 LANFEF----KCTVRSALEGDLVfnneplIQIEGPLAQCQLVETALLNMVN---FQTLIA------------TKAARIKS 150
Cdd:TIGR01514 83 LRNFRFhpeeQVEVGIDDKGKLD------IRISGSWRDTILYEIPLLAIISelyFRFRDAeadyeqqlevleSKLDQLKA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 151 VI-GDDP------LLEFGTRRAQEL---DAAIWGTRAAYIGGADATSNVRAGKIFGIPVSGTHAHSLVQSYGNDYE---- 216
Cdd:TIGR01514 157 EIaAETMfengfrFSEFGTRRRFSLevqDLVTQGLKQAAPSWLLGTSNVHLAKKLGLKPIGTVAHEWFQGHQAISEyrna 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 217 ---AFMAYAKTHRD--CVFLVDTYDT---LKA-GVPSAIRvaremgdkinFLGVRIDSGD-MAYISKRVR--EQLDEAGF 284
Cdd:TIGR01514 237 qkvALECWINEYDGdlGIALTDTFTTdafLRDfRPPFADA----------YDGLRHDSGDpVEWGDKAIAhyQKLGIDPK 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488291059 285 TEAKIYaSNDLD-ENTILNLKMQKSKIDV-WGVGTKLITAYDQ-PALGAVFKLVSIegedgQMKDTIKLSSNAEKVTT 359
Cdd:TIGR01514 307 SKIIIF-SDSLDvEKAIELSHYFKGRVKAsFGIGTNLTNDFGKvEPLNIVIKLVEC-----NGNPVAKLSDSPGKTMG 378
|
|
| NAPRTase |
pfam04095 |
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase ... |
157-363 |
1.91e-09 |
|
Nicotinate phosphoribosyltransferase (NAPRTase) family; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This family also includes Pre-B cell enhancing factor that is a cytokine Swiss:P43490. This family is related to Quinolinate phosphoribosyltransferase pfam01729.
Pssm-ID: 397974 [Multi-domain] Cd Length: 235 Bit Score: 58.16 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 157 LLEFGTRRAQELDAAiwgtraaYIGGADA------TSNVRAGKIFGIPVSGTHAHS-----------LVQSYGNDYEAFM 219
Cdd:pfam04095 3 LHDFGTRRRSSLESQ-------EIVGLAHlvnflgTSNVHFAAKYSIPPAGTSAHEwwgahqeldanLRQFQKDALDLWH 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 220 AYAKTH-----RDCV----FLVDtydtlkAGVPSAIRvaremgdkinFLGVRIDSGD----MAYISKRVREQLDEAGFTE 286
Cdd:pfam04095 76 AEYRGNlgialTDTVtmdaFLKD------FDLYFAKL----------YLGVRPDSGDpvewGEKLIAHYGSTLNIDGYTK 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 287 AKIYaSNDLDENTILNL--KMQKSKIDV-WGVGTKLITAYDQPALGAVFKL--VSIEGEdgqmkdtiKLSSNAEKVTTPG 361
Cdd:pfam04095 140 RLIF-SDGLDVEKIIELleYFKGKGFNIaFGIGTNLTQDLNRDTLGFAVKAtpLNIVIK--------LVEVNGDPVAKIS 210
|
..
gi 488291059 362 KK 363
Cdd:pfam04095 211 DS 212
|
|
| PRK09198 |
PRK09198 |
putative nicotinate phosphoribosyltransferase; Provisional |
99-442 |
1.31e-05 |
|
putative nicotinate phosphoribosyltransferase; Provisional
Pssm-ID: 236407 [Multi-domain] Cd Length: 463 Bit Score: 47.58 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 99 VRSALEGDLVFNNEPLIQIEGPLAQC----QLVETALLNMVNFQTLIATKAARIKSVI-------GDDP------LLEFG 161
Cdd:PRK09198 100 IKAVPEGSVVPVHNVLMTIENTDPEFfwlpNYLETLLLRNVWYPSTVATISWEYKQLIrqylektADDLdflpfqLHDFG 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 162 TRRAQELDAAIWGTRA--AYIGGADATSNVRAGKI--------FGIPVSgthAHSLVQSYGNDYEAFmAYAKTHRD---- 227
Cdd:PRK09198 180 ARGMSSLESAALGGAAhlVSFLGTDTIPALLYAERyynadmagFSIPAT---EHSVMTSWGREGELE-AYRNMIEQfypg 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 228 ----CVflVDTYDTLKA-GVPSAIRVAREMGDKINFLGVRIDSGDMAYISKRVREQLDEA-GFTE-AKIYASndLDENT- 299
Cdd:PRK09198 256 givsIV--SDSYDLWNAiTEPWGGELKDEILARGGTLVIRPDSGDPVTIICGTLELLDEIfGGTVnSKGYKV--LNPHVg 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 300 --------------ILNLKMQK----SKIdVWGVGTKLITAYDQPALGAVFKLVSIEgEDGQMKDTIKlssnaEKVTTPG 361
Cdd:PRK09198 332 viqgdgitldsieaILEALKAKgfaaENI-VFGMGGALLQYVNRDTQGFAMKASAIE-VNGEWRDIFK-----DPITDQG 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 362 KkqvwritrKSDK------KSEGDYVTLWNEDPRQEEEiymfhpvhtfinkyvrdfearPVLQDIFVEGKRVYELpTLDE 435
Cdd:PRK09198 405 K--------KSKKgrlkliKDNGEYRTVDLDEAGDEND---------------------DLLQTVFENGKLLVEY-SLAE 454
|
....*..
gi 488291059 436 IKQYAKE 442
Cdd:PRK09198 455 IRARLHA 461
|
|
| nadV |
PHA02594 |
nicotinamide phosphoribosyl transferase; Provisional |
99-268 |
1.38e-03 |
|
nicotinamide phosphoribosyl transferase; Provisional
Pssm-ID: 222898 [Multi-domain] Cd Length: 470 Bit Score: 41.17 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 99 VRSALEGDLVFNNEPLIQIE--GP----LAQcqLVETALLNMVNFQTLIATKAARIKSVI-------GDDPLLE------ 159
Cdd:PHA02594 103 VRAVPEGTVVPVKVPVLTIEntHPdffwLAG--YLETVILRGVWYPSTVATLSRECKKILkkylketSDNEDEVldfqlh 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291059 160 -FGTRRAQELDAAIWGTRAAYIG--GADATS---------NVRAGKIFGIPVSGTHaHSLVQSYG--NDYEAFMAYAKTH 225
Cdd:PHA02594 181 dFGARGMSSGESAALGGLAHLYNfkGTDTVEalymakryyGDDEVEMAGISVPARE-HSTMCSYGaeNEDEAFKNSLTLY 259
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 488291059 226 RDCVFLV--DTYDtLKAGVPsaiRVAREMGDKI----NFLGVRIDSGDM 268
Cdd:PHA02594 260 GTGIYSIvsDTYD-FKRAVT---EILPELKDEImargGKLVIRPDSGDP 304
|
|
| |
