|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
19-410 |
3.31e-75 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 240.17 E-value: 3.31e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 19 SFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSF 98
Cdd:cd17503 5 AFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 99 SILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSL 178
Cdd:cd17503 85 ASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 179 FMGlsaipeipvkktttldlvsligiallfsgllmflskigtlfgwlsllaavigfvifykrattaeqPLVRLTILKNPA 258
Cdd:cd17503 165 LLA-----------------------------------------------------------------PLLDLRLFKDRN 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 259 FVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIGWL 338
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488291126 339 ALTILLEMPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATIIN 410
Cdd:cd17503 260 LLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
19-433 |
1.07e-52 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 184.12 E-value: 1.07e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 19 SFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSF 98
Cdd:TIGR00711 11 TFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 99 SILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSL 178
Cdd:TIGR00711 91 ELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 179 FMGLSAIPEIPVKKTTTLDLVSLIGIALLFSGLLMFLSKiGTLFGWLS-------LLAAVIGFVIFYKRATTAEQPLVRL 251
Cdd:TIGR00711 171 VVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSE-GPERGWFDsneililSITGLVAIIAFVVWELTDDNPLVDL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 252 TILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLS 331
Cdd:TIGR00711 250 RLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVTIGLI 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 332 L--ATIGWLALTILLEMPvllgFVAGHVTYMI---GLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVA 406
Cdd:TIGR00711 330 LyaVGFYWRAFTFTPDTP----FLAIALPQFIrgfGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALIT 405
|
410 420
....*....|....*....|....*..
gi 488291126 407 TIinIAQDHADNFAQGTTMGSLISLIF 433
Cdd:TIGR00711 406 TI--LTNRTQFHHSQLTETINPVNPNF 430
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-433 |
6.83e-40 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 146.93 E-value: 6.83e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 20 FAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFS 99
Cdd:cd17321 6 FLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 100 ILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLF 179
Cdd:cd17321 86 FLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 180 MGlsaipeipvkktttldlvsligiallfsgllmflskigtlfgwlsllaavigfvifykrattaeqplvrltilknPAF 259
Cdd:cd17321 166 LA---------------------------------------------------------------------------RTF 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 260 VLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIGWLA 339
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 340 LTILLEMPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATIINIAQDHADNF 419
Cdd:cd17321 251 LALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGD 330
|
410
....*....|....
gi 488291126 420 AQGTTMGSLISLIF 433
Cdd:cd17321 331 SGVAALLSAAAAAF 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-401 |
2.79e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.78 E-value: 2.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 1 MEQKNVRLFPAVLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIV 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 81 ANLFFLIGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSS 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 161 LSWHAIFLFLIPVLLLSLFMGLSAIPEipvkktttldlvsligiallfsgllmflskigtlfgwlsllaavigfvifYKR 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPE--------------------------------------------------SRP 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 241 ATTAEQPLVRLTILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQY 320
Cdd:COG2814 191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 321 GAKKPILFGLSLATIGWLALTIlleMPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAI 400
Cdd:COG2814 271 GRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
.
gi 488291126 401 A 401
Cdd:COG2814 348 A 348
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
16-409 |
3.32e-28 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 114.60 E-value: 3.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 16 GIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYS 95
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 96 PSFSILLLGRLFQGASTGIaLPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLL 175
Cdd:cd17504 82 PNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 176 LSLFMglsaipeipvkktttldlvsligiallfsgllmflskigtlfgwlsllaavigfvifykrattaeQPLVRLTILK 255
Cdd:cd17504 161 LLAAL-----------------------------------------------------------------VPLIDLRLLR 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 256 NPAFVLFLCGFLVCQFLLLGISFVLPNFVQ----IVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLS 331
Cdd:cd17504 176 RRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLV 255
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488291126 332 LATIGWLALTILLEMPVLLgfVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATII 409
Cdd:cd17504 256 ISAVGLLLLALLHSSLWAL--VVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
16-413 |
6.64e-23 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 99.57 E-value: 6.64e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 16 GIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYS 95
Cdd:cd17320 5 ALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 96 PSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLL 175
Cdd:cd17320 85 SSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 176 LSLFMGLSAIPEIPVKKTTTLDLVSLIGIALLfsgllmflskigtlfgwlsllaavigfvifykrattaeqplvrltILK 255
Cdd:cd17320 165 LLLLLVLLFLPETLPEEKRKPLLSSLLRAYKR---------------------------------------------VLK 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 256 NPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATI 335
Cdd:cd17320 200 NRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLA 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 336 G--WLALTILLEMPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEkDFGDGNTLFNTLQQFSGAIATAIVATIINIAQ 413
Cdd:cd17320 280 AalVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH-VAGTASALLGFLQFLIGALAGALVGLLPNGTA 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
34-402 |
1.83e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.10 E-value: 1.83e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 34 PTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGASTG 113
Cdd:pfam07690 21 LLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 114 IALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFMGLSAIPEIPVKKT 193
Cdd:pfam07690 101 ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 194 TTLDLVSLIGIALlfsgllmflskigtlfgwlsllaavigfvifykrattaeqplvrLTILKNPAFVLFLCGFLVCQFLL 273
Cdd:pfam07690 181 KPAEEARLSLIVA--------------------------------------------WKALLRDPVLWLLLALLLFGFAF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 274 LGISFVLPnFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIGWLALTILLEMPVLLGFV 353
Cdd:pfam07690 217 FGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLL 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 488291126 354 AGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIAT 402
Cdd:pfam07690 296 LALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
13-404 |
2.09e-20 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 91.86 E-value: 2.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 13 LATGIMSFAGVLIETAMnvtfPTLTKEFGvSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAID 92
Cdd:cd17502 3 LALFLAALDQTIVATAL----PTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLC 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 93 VYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIP 172
Cdd:cd17502 78 GLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 173 VLLLSLFMGLSAIpeipvkktttldlvsligiallfsgllmflskigtlfgwlsllaavigfvifykrattaeqplvrlt 252
Cdd:cd17502 158 IGGLALALLRTIL------------------------------------------------------------------- 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 253 ilknpafVLFLCGFLVCqFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYG-AKKPILFGLS 331
Cdd:cd17502 171 -------LSSIFGFLFG-GALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTI 242
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488291126 332 LATIGWLALTILLEMPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAI 404
Cdd:cd17502 243 LMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
20-415 |
1.30e-18 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 87.86 E-value: 1.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 20 FAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFS 99
Cdd:PRK10504 20 FMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 100 ILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLF 179
Cdd:PRK10504 100 ELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 180 MGLSAIPEIPVkKTTTLDLVSLIGIALLFSGLLMFL---SKIGTLFGWLSLLAA--VIGFVIFYKRATTAEQPLVRLTIL 254
Cdd:PRK10504 180 ATLMLMPNYTM-QTRRFDLSGFLLLAVGMATLTLALdgsKGLGLSPLAIAGLVAvgVVALLLYLLHARNNNRALFSLKLF 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 255 KNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPIL---FGLS 331
Cdd:PRK10504 259 RTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVattLGLA 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 332 LATIGWLALTIL---LEMPVLLgFVAGHVTymiglGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATI 408
Cdd:PRK10504 339 LVSLLFMLVALLgwyYLLPFVL-FLQGMVN-----STRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLL 412
|
....*...
gi 488291126 409 INI-AQDH 415
Cdd:PRK10504 413 LGLfGQQH 420
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-289 |
1.92e-17 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 82.55 E-value: 1.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 7 RLFPAVLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFL 86
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 87 IGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAI 166
Cdd:COG0477 91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 167 FLFLIPVLLLSLFMGLSAIPEIPVKKTTTLDLVSLIGIALLFSGLLMFLSKIGTLFGWLSLLAAVIGFVIFYKRATTAEQ 246
Cdd:COG0477 171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLAL 250
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 488291126 247 PLVRLTILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLG 289
Cdd:COG0477 251 LLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-372 |
2.46e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.39 E-value: 2.46e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 17 IMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSP 96
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 97 SFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLL 176
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 177 SLFMGLSAIPEIPVKKTTtldlvsligiallfsgllmflskigtlfgwlsllaavigfvifyKRATTAEQPLVRLTILKN 256
Cdd:cd17325 163 ALVLALLLLPEPRPPPNK--------------------------------------------RAVSAARLRSGLRLLLRD 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 257 PAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIG 336
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278
|
330 340 350
....*....|....*....|....*....|....*.
gi 488291126 337 WLALTIlleMPVLLGFVAGHVTYMIGLGFAYSNMMT 372
Cdd:cd17325 279 LLLLPL---ATSFWLLLLLLALLGLGLGLVFPATLA 311
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
13-410 |
4.29e-16 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 80.36 E-value: 4.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 13 LATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVqWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAID 92
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 93 VYSPSFSILLLGRLFQGASTGIALpLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILT--SSLSWH------ 164
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRwifyin 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 165 AIFLFLIPVLLLSLFMGLSAIPEIPVKKTTTLDLVSLIGIALLFSGLLMFLSKI---GTLFGWLSllAAVIGFVI----- 236
Cdd:cd06179 159 AIFNALALILLFFFYHPPPRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLswgGNPYPWSS--AHVIAPLViggvl 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 237 -----FYKRATTAEQPLVRLTILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAP 311
Cdd:cd06179 237 liafgLYEWKGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 312 LSGRVLDQYG-AKKPILFGLSLATIGWLALTIL----LEMPVLLGFVAGhvtymIGLGFAYSNMMTTGMSLLEEKDFGDG 386
Cdd:cd06179 317 LAGLLLTKIKhIKWQLVAGFVLFTAFLALLALItpdnKALAIAFSVLAG-----IGIGGPLVLAIVIVQLSVPPEDIGTA 391
|
410 420
....*....|....*....|....
gi 488291126 387 NTLFNTLQQFSGAIATAIVATIIN 410
Cdd:cd06179 392 SGLLGSARALGGAVGTAIFTSILS 415
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
27-343 |
5.09e-16 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 80.16 E-value: 5.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 27 TAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRL 106
Cdd:PRK14995 23 TVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 107 FQGASTGIALPLMFHIILN-FTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFMGLSAI 185
Cdd:PRK14995 103 LLAIGAAMIVPATLAGIRAtFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 186 PEIPVKKTTTLDLVSliGIALLFSGLLMFLSKIGTLFG----WLSLLAAVIGFV---IFYKRATTAEQPLVRLTILKNPA 258
Cdd:PRK14995 183 PRQAGRRDQPLNLGH--ALMLIVAILLLVYSAKTALKGflslWVTSLTLLTGALllgLFIRTQLAASRPMIDMRLFTHRI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 259 FVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIGWL 338
Cdd:PRK14995 261 ILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSALSFY 340
|
....*
gi 488291126 339 ALTIL 343
Cdd:PRK14995 341 GLAMT 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-409 |
8.04e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 78.77 E-value: 8.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 10 PAVLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGL 89
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 90 AIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLF 169
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 170 LIPVLLLSLFMGLSAIPEIPVkktttldlvsligiallfsgllmflskigtlfgwlsllaavigfvifYKRATTAEQPLV 249
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPA-----------------------------------------------GAAAAAKASLRD 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 250 RLTILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFG 329
Cdd:COG2223 198 QLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIV 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 330 LSLATIGWLALTILleMPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATII 409
Cdd:COG2223 278 FALMALGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-409 |
4.36e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.45 E-value: 4.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 11 AVLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLA 90
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 91 IDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFl 170
Cdd:COG2271 91 LFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 171 ipvlllslfmglsaipeipvkktttldlvsligiallfsgllmflskigtlFGWLSLLAAVIgfvifykrattaeqplvr 250
Cdd:COG2271 170 ---------------------------------------------------LGLPGLLLALL------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 251 ltilknpAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGA--KKPILF 328
Cdd:COG2271 181 -------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 329 GLSLATIGWLALTILLEMPVLLGFVAGhvtYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATI 408
Cdd:COG2271 254 GLLLAALALLLLALLPSPALAIALLFL---AGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
.
gi 488291126 409 I 409
Cdd:COG2271 331 L 331
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-404 |
8.15e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.66 E-value: 8.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 12 VLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAI 91
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 92 DVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLI 171
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 172 PVLLLSLFMGLSAIPEIPVKKTTTLDLVSLIgIALLFSGLLMFLSKIGTLFgwlsllaaVIGFVIFYkrattaeqplvrl 251
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLGLLSSL-LLLLRNPRLRLAYLITFLL--------FGGFFALY------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 252 tilknpafvlflcgflvcqflllgiSFVLPNFVQIVLGKNAFVAGLVMLPGAtVGAILAPLSGRVLDQYGaKKPILFGLS 331
Cdd:cd17324 219 -------------------------TYLAPFLTDVPGFSSSAIIGLLLLFGV-AGVVGSPLAGRLADRGG-RRALLIALL 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488291126 332 LATIGWLALTILLemPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEkDFGDGNTLFNTLQQFSGAIATAI 404
Cdd:cd17324 272 LLAAALLLLTLLG--PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE-ARGLASSLYLAAYNLGGALGAAL 341
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
17-433 |
5.78e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.91 E-value: 5.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 17 IMSFAGVLIETAMNVTFPTLTKEF-GVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYS 95
Cdd:cd17473 6 LASTLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 96 PSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILtSSLSWHAIF---LFLIP 172
Cdd:cd17473 86 DSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFlvyLLALP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 173 VLLLSLFMglsaIPEIPVKKTTTLDLVSligiallfsgllmflskigtlfgwlsllaavigfvifykrATTAEQPLVRLt 252
Cdd:cd17473 165 VLILVLLF----LPEPARKSKSAASPGA----------------------------------------ATAAALPWKRV- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 253 ilknpaFVLFLCGFLVcQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSL 332
Cdd:cd17473 200 ------LPIYFLAFLA-MLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFAL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 333 ATIGWLALTILLEMPVllgFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATIINIA 412
Cdd:cd17473 273 MALGFLLLALASGLWV---VLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT 349
|
410 420
....*....|....*....|.
gi 488291126 413 QDHADNFAQGTTMGSLISLIF 433
Cdd:cd17473 350 GGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-354 |
2.07e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 2.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 12 VLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAI 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 92 DVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILtSSLSWHAIFlFLI 171
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPF-FLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 172 PVLLLSLFMGLSAIPEIPVKKTTTLDLVSLIGIALlfsgllmflskigtlfgwlsllaavigfvifykrattaeqplvrl 251
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKK--------------------------------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 252 tILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQ-YGAKKPILFGL 330
Cdd:cd17474 194 -ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGL 272
|
330 340
....*....|....*....|....
gi 488291126 331 SLATIGWLALTILLEMPVLLGFVA 354
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIV 296
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
8-408 |
1.31e-11 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 65.87 E-value: 1.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 8 LFPAVLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLI 87
Cdd:TIGR00710 3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 88 GLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIF 167
Cdd:TIGR00710 83 SSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 168 LFLIPVLLLSLFMGLSAIPEipvkkttTLDLVSLIGIALLFSgllMFLSKIGTLFGWLSLLAAVIGFVIFYKRATTAEqp 247
Cdd:TIGR00710 163 AFLSLAGILLSALIFFILPE-------TLPYEARIQISTYFE---TFLLLLKSKMFWGYALIYGASFGGFFAFFSGAP-- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 248 lvrltilknpafvlflcgflvcqFLLLGISFVLPNFvqivLGKNAFVAGLVMLPGATVGailaplsGRVLDQYGAK--KP 325
Cdd:TIGR00710 231 -----------------------FVYIDIMGVSPSV----FGLLFALNIIAMIFGGFLN-------GRFIKKWGAKslLR 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 326 ILFGLSLATIGWLALTILLEMPVLLGFVAGHVTYMIGLGFAYSNMMTtgmSLLEEKDF--GDGNTLFNTLQQFSGAIATA 403
Cdd:TIGR00710 277 MGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMA---YALEDFPHvaGTASALFGTLRLVLGAIVGY 353
|
....*
gi 488291126 404 IVATI 408
Cdd:TIGR00710 354 LVSLI 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
28-411 |
5.46e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.77 E-value: 5.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 28 AMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLF 107
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 108 QGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFMGLSAIPE 187
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 188 IPVKKTTTLDLVSLigiallfsgllmflskigtlfgwlsllaaviGFVIFYKRATtaeqplvrltilkNPAFVLFLCGFL 267
Cdd:cd17489 174 PPVAAEEAEAGTRA-------------------------------FRRLVEKKVL-------------PPALILFLASIA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 268 VCqflllGISFVLPNFVQIVLGKNafvAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIGWLALTIlleMP 347
Cdd:cd17489 210 YG-----AISTFLPLYAAERGISN---AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF---AG 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488291126 348 VLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATIINI 411
Cdd:cd17489 279 SPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL 342
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-187 |
7.91e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 56.89 E-value: 7.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 52 TIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEK 131
Cdd:TIGR00880 5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 488291126 132 RGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFMGLSAIPE 187
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-180 |
9.62e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 9.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 4 KNVRLFPAVLATGIMSFAGVLIETAMNVTFPT-LTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVAN 82
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 83 LFFLIGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLS 162
Cdd:cd17325 273 LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
|
170
....*....|....*...
gi 488291126 163 WHAIFLFLIPVLLLSLFM 180
Cdd:cd17325 353 FATPFLAAAALLLLAAVL 370
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
15-182 |
1.37e-09 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 59.51 E-value: 1.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 15 TGIMSFAGVLIETAMNVTFP---TLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAI 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPalpQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 92 DVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIF---- 167
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFwfla 160
|
170 180
....*....|....*....|....*.
gi 488291126 168 -----------LFLIPVLLLSLFMGL 182
Cdd:cd17323 161 iisgfclilifLFLPIVLLLGLYVGL 186
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-412 |
4.08e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 58.21 E-value: 4.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 16 GIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYS 95
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 96 PSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSL--SWHAIFLFLIPV 173
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 174 LLLSLFMGLSAIPEIPVKKTTTLdlvsligiallfsgllmflskigtlfgwlsllaavigfvifyKRATTAEQPLVRLTI 253
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKN------------------------------------------EEASSKSVLKLLKRV 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 254 LKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLA 333
Cdd:cd06174 200 LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLL 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488291126 334 TIgwLALTILLEMPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATIINIA 412
Cdd:cd06174 280 MA--LGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT 356
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-409 |
1.19e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 56.42 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 27 TAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRL 106
Cdd:cd17319 20 VNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 107 FQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFlipvlllslfmglsaip 186
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII----------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 187 eipvkktttldlvsligiallfsgllmflskigtlFGWLSLLAAVIGFVIFykrattaeqplvrltilknPAFVLFLCGF 266
Cdd:cd17319 163 -----------------------------------EGLLGLLLAVLWWFYL-------------------RQVWGLALGY 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 267 LVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQY---GAKKPILFGLSLATIGWLALTIL 343
Cdd:cd17319 189 FGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLT 268
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488291126 344 --LEMPVLLGFVAGhvtymIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQQFSGAIATAIVATII 409
Cdd:cd17319 269 tsPVVAVILLSLAG-----FGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLV 331
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
200-412 |
9.34e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 9.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 200 SLIGIALLFSGLLMFLSKIG-------TLFGWLSLLAAVIGFVIFY---KRATTAEQPLVRL-----TILKNPAFVLFLC 264
Cdd:COG2211 156 AGLGGLLASVLPPPLVAAFGgdaalgyRLTALIFAVLGLLAFLLTFfgtKERPVPEEEKVSLkeslkALLKNRPFLLLLL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 265 GFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIGWLALTILL 344
Cdd:COG2211 236 AYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLG 315
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488291126 345 EMPVLLGFVAghvtyMIGLGFAYSNMMTTGMSLL------EEKDFGDGNT-----LFNTLQQFSGAIATAIVATIINIA 412
Cdd:COG2211 316 PGNLWLLLVL-----AALAGIGLGAILVLPWAMLadvvdyDEWKTGRRREglyfgIFTFAIKLGQALAGALAGLLLALF 389
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
34-378 |
1.02e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.72 E-value: 1.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 34 PTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGASTG 113
Cdd:COG2807 42 PEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 114 IALPLMFHIILNFTPlEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFMGLSAIPEIPvkkt 193
Cdd:COG2807 122 VGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 194 ttldlvsligiallfsgllmflskigtlfgwlsllaavigfvifyKRATTAEQPLVRLTILKNPAFVLFLCGFLVCQFLL 273
Cdd:COG2807 197 ---------------------------------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 274 LGISFVLPNFVQiVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIgwLALTILLEMPVLLGFV 353
Cdd:COG2807 232 YAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGL--AGLLGLLLAPGSLPWL 308
|
330 340
....*....|....*....|....*
gi 488291126 354 AghvtyMIGLGFAYSNMMTTGMSLL 378
Cdd:COG2807 309 W-----AVLLGLGQGGLFPLALTLI 328
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-189 |
2.02e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.95 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 8 LFPAVLATGIMSFAGVLIETAMNVTFPT-LTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRR--LFIVANLF 84
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 85 FLIGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWH 164
Cdd:COG2271 258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
|
170 180
....*....|....*....|....*
gi 488291126 165 AIFLFLIPVLLLSLFMGLSAIPEIP 189
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
7-179 |
2.56e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.20 E-value: 2.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 7 RLFPAVLATGIMSFAGVLIETAMNVTFPTLTK-EFGVSTGTVQWVTTIYLLVISIM-VPLSNYLLKTYSLRRLFIVANLF 84
Cdd:cd17330 171 FFLPPLRRLLLVYFLIALAFAGLESVFSLFLKdRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 85 FLIGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWH 164
Cdd:cd17330 251 AIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPG 330
|
170
....*....|....*
gi 488291126 165 AIFLFLIPVLLLSLF 179
Cdd:cd17330 331 VPFLLAAGLLLIALF 345
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-184 |
5.51e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.39 E-value: 5.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 9 FPAVLATGIMSFAGVLIETAMNVTFPT-LTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLI 87
Cdd:COG0738 209 NPRLLLGGLAIFLYVGAEGAIGDWLPLyLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAV 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 88 GLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPlEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIF 167
Cdd:COG0738 289 GLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAF 367
|
170
....*....|....*..
gi 488291126 168 LFLIPVLLLSLFMGLSA 184
Cdd:COG0738 368 LVPLVCYLLILLLALAL 384
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
10-355 |
1.44e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.35 E-value: 1.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 10 PAVLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGL 89
Cdd:cd17355 3 VVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 90 AIDVYSPS-FSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFL 168
Cdd:cd17355 83 VLLALATSlWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 169 FLIPVLLLSLFmglsaipeipvkktttldlvsligIALLFsgllmflskigtLFGWLSLLAAVIgfvifYKRATTAEQPL 248
Cdd:cd17355 163 VLALLALLVLV------------------------PVLLL------------LRRRPADLALRA-----YDDASPASPGS 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 249 VRLTILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIvLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKP--I 326
Cdd:cd17355 202 TLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLlaA 280
|
330 340
....*....|....*....|....*....
gi 488291126 327 LFGLSLATIGWLALTILLeMPVLLGFVAG 355
Cdd:cd17355 281 SYALRALGLALLLLLPFP-PLALLLFAAL 308
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-377 |
2.34e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.47 E-value: 2.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 1 MEQKNVRLfpAVLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIV 80
Cdd:COG0738 1 MSKKNYRR--ALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 81 ANLFFLIGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPlEKRGTMMGVGTLTTSIAPAIGPTYGGILTS- 159
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILl 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 160 --SLSWHAIFLFL-IPVLLLSLFMGLSAIPEIPVKKtttldlvsligiallfsgllmflskigtlfgwlsllaavigfvi 236
Cdd:COG0738 158 glSLSWHLPYLILaVLLLLLALLFLRSKLPEIEEEE-------------------------------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 237 fykrATTAEQPLVRLTILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRV 316
Cdd:COG0738 194 ----EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL 269
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488291126 317 LDQYGAKKPILFGLSLATIGWLALTILLEMPVLLGFVaghvtymIGLGFAYSNMMTTGMSL 377
Cdd:COG0738 270 LKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGL-------ALVGLGLSLMFPTIFSL 323
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-187 |
3.47e-06 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 49.14 E-value: 3.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 33 FPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGAST 112
Cdd:PRK11102 14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAA 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488291126 113 GIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFMGLSAIPE 187
Cdd:PRK11102 94 AAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPE 168
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
17-180 |
3.62e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.89 E-value: 3.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 17 IMSFAGVLIE----TAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAID 92
Cdd:TIGR00895 20 ILSFLIMLMDgydlAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLC 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 93 VYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLF--L 170
Cdd:TIGR00895 100 ALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVggI 179
|
170
....*....|
gi 488291126 171 IPVLLLSLFM 180
Cdd:TIGR00895 180 APLLLLLLLM 189
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
15-189 |
4.40e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 48.81 E-value: 4.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 15 TGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVY 94
Cdd:pfam00083 16 TGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 95 SP---SFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTL--TTSIAPAIGPTYGGILTSSLSWHAIFLF 169
Cdd:pfam00083 96 AKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLaiTFGILLAYIFGLGLNKTSNSDGWRIPLG 175
|
170 180
....*....|....*....|
gi 488291126 170 LIPVLLLSLFMGLSAIPEIP 189
Cdd:pfam00083 176 LQLVPALLLIIGLLFLPESP 195
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
64-180 |
7.03e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.95 E-value: 7.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 64 LSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTT 143
Cdd:cd17474 254 VGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVR 333
|
90 100 110
....*....|....*....|....*....|....*..
gi 488291126 144 SIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFM 180
Cdd:cd17474 334 FLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
34-183 |
8.98e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 47.59 E-value: 8.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 34 PTLTKEFGVSTGTVQWVTTIYLLV--ISIMV--PLSNYLLktyslRRLFIVANL-FFLIGLAIDVYSPSFSILLLGRLFQ 108
Cdd:PRK11652 32 ADMARDLNVREGAVQAVMAAYLLTygLSQLFygPLSDRVG-----RRPVILVGMsIFILGTLVALFAHSLTVLIAASAIQ 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488291126 109 GASTGIALPL---MFHIILNFTPLEKRGTMMGVGTLttsIAPAIGPTYGGILTSSLSWHAIFLFLipvLLLSLFMGLS 183
Cdd:PRK11652 107 GLGTGVGGVMartLPRDLYEGTQLRHANSLLNMGIL---VSPLLAPLIGGLLTTLFGWRACYLFL---LLLGAGVTFS 178
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-238 |
1.23e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 1.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 31 VTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGA 110
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 111 STGIALPLMFHIILNFTPlEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFMGLSAIPEIPV 190
Cdd:cd17478 97 GSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 488291126 191 KKTTTLDLVSLIGIALLFSGLLMFLSKIGTLFGWlsLLAAVIGFVIFY 238
Cdd:cd17478 176 EAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSW--VLSSLTTFLPFY 221
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
27-181 |
6.77e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 6.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 27 TAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRL 106
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488291126 107 FQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLF-LIPVLLLSLFMG 181
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLgGVPPLILLPLLR 171
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
33-213 |
1.81e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.32 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 33 FPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGAST 112
Cdd:cd17477 19 LSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 113 GIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGP---TYGGILTSSLSWHAIFLFLIPVLLlsLFMGLSAIPEIP 189
Cdd:cd17477 99 AGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPlllALVGTAGALPFLIAAVLLLLALVP--LLLTRRAAPEIE 176
|
170 180
....*....|....*....|....
gi 488291126 190 VKKTTTLDLVSLIGIALLFSGLLM 213
Cdd:cd17477 177 EAESISLRRLLRIAPLALLGAFVA 200
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
10-176 |
2.79e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.95 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 10 PAVLATGIMSFAGVLIETAMNVTFPTLTKEFG-VSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIG 88
Cdd:cd17473 197 KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 89 LAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGP-------TYGGILTSSL 161
Cdd:cd17473 277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPlvlgplvNLTGGLSGAF 356
|
170
....*....|....*
gi 488291126 162 SWHAIFLFLIPVLLL 176
Cdd:cd17473 357 LILGVLALVLAIVLL 371
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
36-354 |
3.19e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 3.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 36 LTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGASTGIA 115
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 116 LPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSsLSWHAIFLFLIPVLLLSLFMGLSAIPEIPVKKTtt 195
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRR-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 196 ldlvsligiallfsgllmflskigtlfgwlsllaavigfvifykRATTAEQPLVRLTILKNPAFVLFLCGFLVCQFLLLG 275
Cdd:cd17329 183 --------------------------------------------AAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQ 218
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488291126 276 ISFVLPNFVQIVLGKNAFVAGLVMLPGATVGAILAPLSGRVLDQYGAKKPILFGLSLATIGWLALTILLEMPVLLGFVA 354
Cdd:cd17329 219 LESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMI 297
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
52-182 |
4.72e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.20 E-value: 4.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 52 TIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEK 131
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR 313
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 488291126 132 RGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSLFMGL 182
Cdd:cd17489 314 RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
12-182 |
5.82e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.77 E-value: 5.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 12 VLATGIMSFAGVLIETAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAI 91
Cdd:cd17352 5 VFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 92 DVYSPSFSILLlgrLFQGASTGIALPLMFH---IILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFL 168
Cdd:cd17352 85 SSFATSLWQLY---LTYGVLGGLGLGLIYSpaiVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALL 161
|
170
....*....|....
gi 488291126 169 FLIPVLLLSLFMGL 182
Cdd:cd17352 162 ILGGLCLNLCVCGL 175
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
38-178 |
1.40e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 38 KEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGASTGIALP 117
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488291126 118 LMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVLLLSL 178
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIAL 367
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
75-233 |
1.54e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 75 RRLFIVANLFFLIGLAIDVY-SPSFSILLLGRLFQG--ASTGIALPLMFhiiLNFTPLEKRGTMMGVGTLTTSIAPAIGP 151
Cdd:cd17490 61 RKLFIIIGLLFTVLASLIMIlFPSPWGLLIARFLSGiaAATWVSFTVLY---ASYFPPDEAAKAMGLINLVNNLGQLIAF 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 152 TYGGILTSSLSWHAIFLFLIPVLLLSLFMGLSAIPEIPVKKTTTLDLVSLIGIA-----LLFSGL--LMFLSKIGTLFGW 224
Cdd:cd17490 138 LIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLSVLkdkklLFFSLLaiLQQMITFSTTFGF 217
|
....*....
gi 488291126 225 LSLLAAVIG 233
Cdd:cd17490 218 TPLIAKQLG 226
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
17-180 |
3.12e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 39.52 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 17 IMSFAGVLIETAMNVTfptLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVY-- 94
Cdd:cd17390 183 LMGFSVLLFRSNFSLY---LEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLLGLal 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 95 SPSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWHAIFLFLIPVL 174
Cdd:cd17390 260 APSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGAVLAL 339
|
....*.
gi 488291126 175 LLSLFM 180
Cdd:cd17390 340 AAILLM 345
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
34-175 |
3.14e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 34 PTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFsILLLGRLFQGASTG 113
Cdd:cd17339 23 PEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIA-LLFLGTALAGAGIA 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488291126 114 IALPLMFHIILNFTPlEKRGTMMGVGTLTTSIAPAIGPTYGGILTSSLSWH---AIFLFLIPVLL 175
Cdd:cd17339 102 VGNVLLPSLIKRDFP-RRVGLMTGLYTTSMNLGAALASGLSVPLAQALGGGwrgALAIWALPALL 165
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
258-352 |
3.31e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 39.48 E-value: 3.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 258 AFVLFLCgflvcqFLLLGISF-VLPNFVQIVLGKNAFVAGLVMlpGATVGAILA--PLSGRVLDQYGAKKPILFGL---- 330
Cdd:PRK05122 21 VMFTFIS------YLTIGLPLaVLPGYVHDQLGFSAFLAGLVI--SLQYLATLLsrPHAGRYADTLGPKKAVVFGLcgca 92
|
90 100 110
....*....|....*....|....*....|..
gi 488291126 331 --------SLATIGW--LALTILLEMPVLLGF 352
Cdd:PRK05122 93 lsgllyllAGLLAAWpvLSLLLLLLGRLLLGI 124
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
83-413 |
3.66e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.51 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 83 LFFLIGLAIDVYSPSFSILLLGRLFQG----ASTGIALplmfhiILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGILT 158
Cdd:cd17472 70 LLFIAGSLLAAYATSIYGLILGRALQGsgaiSSVVMAL------LADLTREENRTKAMALIGASIGIAFAISMVLGPLLA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 159 SSLSWHAIFLFLIPVLLLSLFMGLSAIPEIPVKKTttldlvsligiallfsgllmflskigtlfgwlsllaavigfvify 238
Cdd:cd17472 144 AHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQ--------------------------------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 239 KRATTAEQPlvrLTILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKNAFVaGLVMLPGATVGAILAPLSGRVLD 318
Cdd:cd17472 179 ISEKEKKKL---KKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQL-WKVYLPAILIGFILMVPFVIYAE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 319 QYGAKKPIlFGLSLATIGWLALTILLEMPVLLGFVAGHVTYMIGLGFAYSNMMTTGMSLLEEKDFGDGNTLFNTLQ---Q 395
Cdd:cd17472 255 KKGKMKQV-FVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQflgS 333
|
330
....*....|....*...
gi 488291126 396 FSGAIATAIVATIINIAQ 413
Cdd:cd17472 334 FLGGALGGLLWGLLGYSS 351
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
27-175 |
3.78e-03 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 39.34 E-value: 3.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 27 TAMNVTFPTLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAIDVYSPSFSILLLGrl 106
Cdd:TIGR00892 36 KAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLASLGMILASFSSNVIELYLT-- 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488291126 107 fQGASTGIALPLMFH---IILNF-----TPLEKRGTMMGVGTLTTSIAPaigptYGGILTSSLSWHAIFLFLIPVLL 175
Cdd:TIGR00892 114 -AGFITGLGLAFNFQpslTMLGKyfyrrRPLANGLAMAGSPVFLSTLAP-----LNQYLFESFGWRGSFLILGGLLL 184
|
|
| MFS_SLCO4C_OATP4C |
cd17463 |
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ... |
20-344 |
6.09e-03 |
|
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341021 [Multi-domain] Cd Length: 429 Bit Score: 38.96 E-value: 6.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 20 FAGVLIETAMNVTFPTLTKEFGVS---TGTVQWVTTIYLLVISIMVplSNYLLKTYSLRRLFIVAnlfFLIGLAIDVYS- 95
Cdd:cd17463 14 VQGIVVNGLVNISISTIEKRYELSsslTGLISSSYDISFCLLSLFV--SFYGERGHKPRWLAFSA---FMIGLGSLVFSl 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 96 PSFSILLLGRLFQGASTGIALPLMFHIILNFTPLEKRGTMMGVGTLTTSIAPAIGPTYGGiltsslswhaiflflipvLL 175
Cdd:cd17463 89 PHFFVFILGQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGG------------------QL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 176 LSLFmglsaipeIPVKKTTTLDLVS----LIGIALlfsgllmflskIGTLFGWLSLLAAVIGFVIFYKRATtaeqplvrl 251
Cdd:cd17463 151 LNIY--------IDVNKGQSVDLTEedprWLGAWW-----------IGFLMCWLIAWCLIAPFSCFPKHLP--------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 252 TILKNPAFVLFLCGFLVCQFLLLGISFVLPNFVQIVLGKN----AFVAGLVMLPGATVGAIlapLSGRVLDQY--GAKKP 325
Cdd:cd17463 203 GLLKNPVFMCLTISSCSEALITTGFATFLPKFIENQFGQTssfaAILGGLVLIPGAAIGQI---LGGIIVSKFklKCKNM 279
|
330
....*....|....*....
gi 488291126 326 ILFGLSLATIGWLALTILL 344
Cdd:cd17463 280 IKFAIITTTVSLLLLSVFI 298
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
75-190 |
6.11e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 38.71 E-value: 6.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 75 RRLFIVANLFFLIGLAIDVYSPSFSILLLGRLFQGASTGIA---LPlMFhiILNFTPLEKRGTMmgvgTLTTSIAPAIGP 151
Cdd:cd17358 71 KRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAAsvvVP-VY--IAEIAPKNVRGAL----GSLNQLLVNIGI 143
|
90 100 110
....*....|....*....|....*....|....*....
gi 488291126 152 TYGGILTSSLSWHAIFLFLIpVLLLSLFMGLSAIPEIPV 190
Cdd:cd17358 144 LLGYVLGSFLPWRTLALIGA-IPPVVFLILLFFIPESPR 181
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
12-176 |
8.71e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.34 E-value: 8.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 12 VLATGIMSFAGVLIETAMNVTFptLTKEFGVSTGTVQWVTTIYLLVISIMVPLSNYLLKTYSLRRLFIVANLFFLIGLAI 91
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYY--FKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291126 92 DVYSP--SFSILLLGRLFQGASTGIALPLMFHIILNFTPLEK-------RGTMMGVGTLTTSIAPAIGPTYGGIL----- 157
Cdd:COG2211 311 LFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLlalfg 390
|
170 180
....*....|....*....|....*..
gi 488291126 158 --------TSSLSWHAIFLFLIPVLLL 176
Cdd:COG2211 391 yvagaaqsPSALTGIRLLFFLLPAVLL 417
|
|
| |
