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Conserved domains on  [gi|488291764|ref|WP_002362972|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Enterococcus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
9-135 3.69e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.80  E-value: 3.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291764   9 SQLLCQLKVLDQKITKVFEEQV---GLSLTRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPE 85
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALaelGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 488291764  86 NNREVLVHLTEKAQQELQQCTAKQQTVTEIIPSTFTKDDCRQLKELLTKL 135
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
9-135 3.69e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.80  E-value: 3.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291764   9 SQLLCQLKVLDQKITKVFEEQV---GLSLTRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPE 85
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALaelGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 488291764  86 NNREVLVHLTEKAQQELQQCTAKQQTVTEIIPSTFTKDDCRQLKELLTKL 135
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-124 7.93e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 81.10  E-value: 7.93e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291764    31 GLSLTRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPENNREVLVHLTEKAQQELQQCTAKQQ 110
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....
gi 488291764   111 TVTEIIPSTFTKDD 124
Cdd:smart00347  87 ETLAELLAGLTAEE 100
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 32-90 3.95e-14

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 62.56  E-value: 3.95e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488291764   32 LSLTRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPENNREV 90
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 35-99 1.79e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 45.75  E-value: 1.79e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488291764  35 TRYELLMILKERqPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPennREVLVHLTEKAQ 99
Cdd:cd00090    8 TRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG---RRVYYSLTDAER 68
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
53-135 1.50e-05

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 42.19  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291764  53 EIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPENNREVLVHLTEKAQQELQQCTAK-QQTVTEIIPSTFTKDDCRQLKEL 131
Cdd:PRK11512  59 ELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLvGQDLHQELTKNLTADEVATLEHL 138


                 ....
gi 488291764 132 LTKL 135
Cdd:PRK11512 139 LKKV 142
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 35-82 1.39e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 35.51  E-value: 1.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 488291764  35 TRYELLMILKERQPCLqTEIQEHLKIDSGAVTRHLKILEEKQYVTRQR 82
Cdd:NF033788  12 TRLRILELLAEGELCV-CELAEALGLSQSAVSQHLKVLRDAGLVTSRR 58
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
9-135 3.69e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 90.80  E-value: 3.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291764   9 SQLLCQLKVLDQKITKVFEEQV---GLSLTRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPE 85
Cdd:COG1846   10 ERLGLLLRRLARALRRALDRALaelGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 488291764  86 NNREVLVHLTEKAQQELQQCTAKQQTVTEIIPSTFTKDDCRQLKELLTKL 135
Cdd:COG1846   90 DRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRL 139
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-124 7.93e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 81.10  E-value: 7.93e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291764    31 GLSLTRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPENNREVLVHLTEKAQQELQQCTAKQQ 110
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARS 86

                           90
                   ....*....|....
gi 488291764   111 TVTEIIPSTFTKDD 124
Cdd:smart00347  87 ETLAELLAGLTAEE 100
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 32-90 3.95e-14

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 62.56  E-value: 3.95e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488291764   32 LSLTRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPENNREV 90
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-89 1.27e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 48.35  E-value: 1.27e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 488291764   31 GLSLTRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPENNRE 89
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 35-99 1.79e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 45.75  E-value: 1.79e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488291764  35 TRYELLMILKERqPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPennREVLVHLTEKAQ 99
Cdd:cd00090    8 TRLRILRLLLEG-PLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREG---RRVYYSLTDAER 68
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
53-135 1.50e-05

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 42.19  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291764  53 EIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPENNREVLVHLTEKAQQELQQCTAK-QQTVTEIIPSTFTKDDCRQLKEL 131
Cdd:PRK11512  59 ELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQLvGQDLHQELTKNLTADEVATLEHL 138


                 ....
gi 488291764 132 LTKL 135
Cdd:PRK11512 139 LKKV 142
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 42-91 2.17e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 39.51  E-value: 2.17e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488291764  42 ILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPENNREVL 91
Cdd:COG1974   19 IRERGYPPSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKSRAIELL 68
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
35-105 2.69e-04

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 37.56  E-value: 2.69e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 488291764  35 TRYELLMILKERqPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRnpeNNREVLVHLTEKAQQELQQC 105
Cdd:COG0640   21 TRLRILRLLAEG-ELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRR---EGRWVYYRLADEALAELLEW 87
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
27-98 3.10e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 38.71  E-value: 3.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488291764  27 EEQVGLSLTRYE----LLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPennREVLVHLTEKA 98
Cdd:COG3398   86 EEKKILAYLRREtprrILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDG---RNVRYYLNPPE 158
Rfk COG1339
Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal ...
 51-105 3.33e-04

Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal CTP-dependent riboflavin kinase is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440950 [Multi-domain]  Cd Length: 219  Bit Score: 39.06  E-value: 3.33e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488291764  51 QTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPennREVLVHLTEKAQQELQQC 105
Cdd:COG1339   25 SSELAKRLGISQQTASRRLQELEDAGLIERDLVG---DGQWVKITEKGEELLRRE 76
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
35-82 4.39e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 38.75  E-value: 4.39e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 488291764  35 TRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQR 82
Cdd:COG2345   14 TRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERET 61
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
38-96 4.93e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.42  E-value: 4.93e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 488291764    38 ELLMILKERQPCLqTEIQEHLKIDSGAVTRHLKILEEKQYVTRQRNPennREVLVHLTE 96
Cdd:smart00418   1 KILKLLAEGELCV-CELAEILGLSQSTVSHHLKKLREAGLVESRREG---KRVYYSLTD 55
MJ0558 COG1497
Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];
34-79 5.57e-04

Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];


Pssm-ID: 441106  Cd Length: 261  Bit Score: 38.29  E-value: 5.57e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 488291764  34 LTRYELLMILKERQP-CLQTEIQEHLKIDSGAVTRHLKILEEKQYVT 79
Cdd:COG1497   10 ATRFQILVEIAERQPaVRQGEIADKLGVTPQAVSEYIKELVEEGLVE 56
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
32-80 6.18e-04

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 38.34  E-value: 6.18e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 488291764  32 LSLTRYELLMILKERqPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTR 80
Cdd:COG4742   14 LSEKRKNILLLLAEG-PKTRSELAESLDVSRSTILRQLKELEERGLIER 61
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 35-74 1.16e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 34.73  E-value: 1.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 488291764   35 TRYELLMILKERQPCLqTEIQEHLKIDSGAVTRHLKILEE 74
Cdd:pfam01022   3 TRLKILKLLAEGELCV-CELAEELGLSQSTVSHHLKKLRE 41
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 35-82 1.39e-03

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 35.51  E-value: 1.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 488291764  35 TRYELLMILKERQPCLqTEIQEHLKIDSGAVTRHLKILEEKQYVTRQR 82
Cdd:NF033788  12 TRLRILELLAEGELCV-CELAEALGLSQSAVSQHLKVLRDAGLVTSRR 58
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
35-82 2.42e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.39  E-value: 2.42e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 488291764  35 TRYELLMILKERqPCLQTEIQEHLKIDSGAVTRHLKILEEKQYVTRQR 82
Cdd:COG1777   18 TRRRILALLSEE-PAYVSELARELGVSRQAVYKHLRKLEEAGLVESYR 64
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 35-74 4.39e-03

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 33.67  E-value: 4.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 488291764   35 TRYELLMILKERQPCLQTEIQEHLKIDSGAVTRHLKILEE 74
Cdd:pfam12840  11 TRLRILRALVGDEPLTASELARRLDISRNTLSYHLRKLEE 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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