|
Name |
Accession |
Description |
Interval |
E-value |
| pcrA |
TIGR01073 |
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. ... |
7-750 |
0e+00 |
|
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273429 [Multi-domain] Cd Length: 726 Bit Score: 1103.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 7 LVQGMNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLLETGGEDV 86
Cdd:TIGR01073 1 LLAHLNPEQREAVKTTEGPLLIMAGAGSGKTRVLTHRIAHLIAEKNVAPWNILAITFTNKAAREMKERVEKLLGPVAEDI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 87 WVSTFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKTLMKRILNDLNIDSKKYDPRSILGTISNAKNELQTPEKVAEMQGS 166
Cdd:TIGR01073 81 WISTFHSMCVRILRRDIDRIGINRNFSIIDPTDQLSLMKTILKDKNLDPKKFEPRSILGTISNAKNELLPPEDFAKEATN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 167 LYEEIVAKCYEAYQKELRKNQCMDFDDLIMNTIRLFNEQPDTLAFYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKNLC 246
Cdd:TIGR01073 161 YFEKVVAEVYQEYQKRLLRNNALDFDDLIMTTINLFQRVPDVLEYYQRKFQYIHVDEYQDTNRAQYTLVRLLASRFRNLC 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 247 VVGDADQSIYGWRGADMQNILDFEKDYPDASVILLEQNYRSTKNILAAANDVIKNNRNRREKELWTENIDGEKIVYYRGD 326
Cdd:TIGR01073 241 VVGDADQSIYGWRGADIQNILSFEKDYPNATTILLEQNYRSTKNILQAANEVIEHNSNRKPKNLWTENSSGDKITYYEAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 327 TERDETQFIVSQIQKEMRENDRIYGDFAVLYRTNAQSRVVEEMLLKSNIPYTMVGGHKFYDRKEIKDILAYLSLIANPDD 406
Cdd:TIGR01073 321 TERDEAQFVAGEIDKLVKNGERKYGDFAILYRTNAQSRVFEETLLKANIPYKIVGGLKFYDRKEIKDILAYLRVIANPDD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 407 SISFERIVNEPKRGIGKSSIEKLRLFADTHGWALLEAAQNVDLA-NISGKAGKELGNFGMMIQDLTKTVPYLTITELVKE 485
Cdd:TIGR01073 401 DLSLLRIINVPKRGIGASSLEKIVNYALELNISLFEAIGEIDEIgGLAAKSANALLAFATMIENLRQQQEYLSPTELVEE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 486 TLQRSGYREALMAQNNLESQARLENLDEFLSVTQEFDKrfeaqnnddpNGEETKLADFLTDLALVSDLDNLEESSS--QV 563
Cdd:TIGR01073 481 VLDKSGYREMLKAEKTEEAQSRLENLDEFLSVTKEFED----------ESEDKSLIDFLTDLALVSDLDELEETEEggAV 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 564 TLMTLHAAKGLEFPVVFLMGLEEGVFPLSRAMLEESELEEERRLAYVGITRAEEALFLTNAYSRTLYGRTQYNRPSRFLE 643
Cdd:TIGR01073 551 TLMTLHAAKGLEFPVVFLIGMEEGVFPHSRSLMDEKELEEERRLAYVGITRAEEELYLTHATMRTLFGRIQMNPPSRFLN 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 644 EIEAERLMKQGAAANLQKAPARTfdPKVFKPSASKPAYTQPATksvsnkvasGGEKVSWQAGDKVQHKAWGVGTVVRVGG 723
Cdd:TIGR01073 631 EIPAELLETASTGRRTGATDPKG--PSIRQAGASRPTTSQPTA---------GGDTLSWAVGDRVNHKKWGIGTVVSVKG 699
|
730 740
....*....|....*....|....*..
gi 488291971 724 SAKDLELDIAFPEKGIKRLLAAFAPIE 750
Cdd:TIGR01073 700 GGDDQELDIAFPSIGVKRLLAAFAPIE 726
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
6-713 |
0e+00 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 940.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 6 ALVQGMNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLLETGGED 85
Cdd:COG0210 2 DLLAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRIAYLIAEGGVDPEQILAVTFTNKAAREMRERIEALLGRLARG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 86 VWVSTFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKTLMKRILNDLNIDSKKYDPRSILGTISNAKNELQTPEKVAE-MQ 164
Cdd:COG0210 82 LWVGTFHSLALRILRRHAELLGLPPNFTILDGDDQLRLIKELLKELGLDEKRFPPRELLSLISRAKNEGLTPEELAElLA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 165 GSLYEEIVAKCYEAYQKELRKNQCMDFDDLIMNTIRLFNEQPDTLAFYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKN 244
Cdd:COG0210 162 ADPEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLLEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRLLAGDGRN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 245 LCVVGDADQSIYGWRGADMQNILDFEKDYPDASVILLEQNYRSTKNILAAANDVIKNNRNRREKELWTENIDGEKIVYYR 324
Cdd:COG0210 242 LCVVGDDDQSIYGFRGADPENILRFEKDFPDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKNLWTDNGEGEKVRLYV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 325 GDTERDETQFIVSQIqKEMRENDRIYGDFAVLYRTNAQSRVVEEMLLKSNIPYTMVGGHKFYDRKEIKDILAYLSLIANP 404
Cdd:COG0210 322 APDEEEEARFVADEI-RELHEEGVPLSDIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERAEIKDLLAYLRLLANP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 405 DDSISFERIVNEPKRGIGKSSIEKLRLFADTHGWALLEAAQNVDLAN-ISGKAGKELGNFGMMIQDLTKTVPYLTITELV 483
Cdd:COG0210 401 DDDVALLRILNVPRRGIGAATLERLREAAREEGISLLEALRDLGELAgLSGRAAKALRRFAELLEALRAAAERLPLEELL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 484 KETLQRSGYREALMAQNNLESQARLENLDEFLSVTQEFDKRfeaqnnddpnGEETKLADFLTDLALVSDLDNLEESSSQV 563
Cdd:COG0210 481 EALLDESGYEEELREEAGEEAERRLENLEELVDAAARFEER----------NPGASLEAFLEELALLSDLDAADEDEDAV 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 564 TLMTLHAAKGLEFPVVFLMGLEEGVFPLSRAMLEESELEEERRLAYVGITRAEEALFLTNAYSRTLYGRTQYNRPSRFLE 643
Cdd:COG0210 551 TLMTLHAAKGLEFPVVFLVGLEEGLFPHQRSLDDEEELEEERRLFYVAITRARERLYLTYAASRRLWGETQDNEPSRFLD 630
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 644 EIEAERLMKQGAAANLQKAPARTFDPKVFKPSASKPAYTQPATKSVSNKVASGGEKVSWQAGDKVQHKAW 713
Cdd:COG0210 631 ELPEELLEWVRPKAEAAAAAASAAAALPASGAGAAALAAGAAAAAAAAGGGAAVAGAGLGRAAAAGGADG 700
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
6-752 |
0e+00 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 645.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 6 ALVQGMNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLLETGGED 85
Cdd:PRK11773 5 YLLDSLNDKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQLLGTSQGG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 86 VWVSTFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKTLMKRILNDLNIDSKKYDPRSILGTISNAKNELQTPEKVaEMQG 165
Cdd:PRK11773 85 MWVGTFHGLAHRLLRAHWQDANLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAQWYINGQKDEGLRPQHI-QSYG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 166 SLYEEIVAKCYEAYQKELRKNQCMDFDDLIMNTIRLFNEQPDTLAFYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKNL 245
Cdd:PRK11773 164 DPVEQTWLKIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYQERFTHILVDEFQDTNAIQYAWIRLLAGDTGKV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 246 CVVGDADQSIYGWRGADMQNILDFEKDYPDASVILLEQNYRSTKNILAAANDVIKNNRNRREKELWTENIDGEKIVYYRG 325
Cdd:PRK11773 244 MIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTANILKAANALIANNNGRLGKELWTDGGDGEPISLYCA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 326 DTERDETQFIVSQIqKEMRENDRIYGDFAVLYRTNAQSRVVEEMLLKSNIPYTMVGGHKFYDRKEIKDILAYLSLIANPD 405
Cdd:PRK11773 324 FNELDEARFVVERI-KTWQDNGGALSDCAILYRSNAQSRVLEEALLQAGIPYRIYGGMRFFERQEIKDALAYLRLIANRN 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 406 DSISFERIVNEPKRGIGKSSIEKLRLFADTHGWALLEAAQNVdLAN--ISGKAGKELGNFGMMIQDLTKTVPYLTITELV 483
Cdd:PRK11773 403 DDAAFERVVNTPTRGIGDRTLDVVRQTARDRQLTLWQACRAL-LQEkvLAGRAASALQRFIELIDALAQETADMPLHEQT 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 484 KETLQRSGYREALMAQNNLESQARLENLDEFLSVTQEFDKrfeaqnnDDPNGEETKLADFLTDLALVSDLDNLEESSSQV 563
Cdd:PRK11773 482 DRVIKDSGLRAMYEQEKGEKGQARIENLEELVTATRQFSY-------PDEDEDLTPLQAFLSHAALEAGEGQADAHEDAV 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 564 TLMTLHAAKGLEFPVVFLMGLEEGVFPLSRAMLEESELEEERRLAYVGITRAEEALFLTNAYSRTLYGRTQYNRPSRFLE 643
Cdd:PRK11773 555 QLMTLHSAKGLEFPLVFIVGMEEGLFPSQMSLEEGGRLEEERRLAYVGITRAMQKLTLTYAESRRLYGKEVYHRPSRFIR 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 644 EIEAE-----RLmkqgaaanlqkapartfdpkvfKPSASKPAYTQPATKSVSNKVASGgekvsWQAGDKVQHKAWGVGTV 718
Cdd:PRK11773 635 EIPEEcveevRL----------------------RATVSRPVSHQRMGTPAVEANDSG-----FKLGQRVRHPKFGEGTI 687
|
730 740 750
....*....|....*....|....*....|....
gi 488291971 719 VRVGGSAKDLELDIAFPEKGIKRLLAAFAPIEKI 752
Cdd:PRK11773 688 VNFEGSGAHARVQVAFQGQGIKWLVAAYAKLEAV 721
|
|
| uvrD |
TIGR01075 |
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, ... |
7-750 |
0e+00 |
|
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130147 [Multi-domain] Cd Length: 715 Bit Score: 612.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 7 LVQGMNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLLETGGEDV 86
Cdd:TIGR01075 1 LLDGLNDKQREAVAAPPGNLLVLAGAGSGKTRVLTHRIAWLLSVENASPHSIMAVTFTNKAAAEMRHRIGALLGTSARGM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 87 WVSTFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKTLMKRILNDLNIDSKKYDPRSILGTISNAKNELQTPEKVaEMQGS 166
Cdd:TIGR01075 81 WIGTFHGLAHRLLRAHHLDAGLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAMWYINNQKDEGLRPSHI-QAFDN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 167 LYEEIVAKCYEAYQKELRKNQCMDFDDLIMNTIRLFNEQPDTLAFYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKNLC 246
Cdd:TIGR01075 160 PVERTWIKIYQAYQEACDRAGLVDFAELLLRAHELLRNKPHILQHYQERFTHILVDEFQDTNKIQYAWIRLLAGNTGNVM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 247 VVGDADQSIYGWRGADMQNILDFEKDYPDASVILLEQNYRSTKNILAAANDVIKNNRNRREKELWTENIDGEKIVYYRGD 326
Cdd:TIGR01075 240 IVGDDDQSIYGWRGAQVENIQKFLKDFPGAETIRLEQNYRSTANILAAANALIANNDERLGKNLWTDGEVGEPISLYSAF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 327 TERDETQFIVSQIqKEMRENDRIYGDFAVLYRTNAQSRVVEEMLLKSNIPYTMVGGHKFYDRKEIKDILAYLSLIANPDD 406
Cdd:TIGR01075 320 NELDEARFVVSRI-KTWQRNGGALDECAVLYRSNAQSRVLEEALLQASIPYRIYGGMRFFERQEIKDALAYLRLIANRND 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 407 SISFERIVNEPKRGIGKSSIEKLRLFADTHGWALLEAAQNVDLAN-ISGKAGKELGNFGMMIQDLTKTVPYLTITELVKE 485
Cdd:TIGR01075 399 DAAFERVINTPTRGIGDRTLDVVRQAARDRGLTLWQAARELTQEKvLAGRAASALQRFVELIEALANETADMPLHVQTDH 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 486 TLQRSGYREALMAQNNLESQARLENLDEFLSVTQEFDKRFEAQnnddpngEETKLADFLTDLALVSDLDNLEESSSQVTL 565
Cdd:TIGR01075 479 VIKDSGLREMYQQEKGEKGQARIENLEELVTATRQFSLPENDE-------DMTPLTAFLSHAALEAGEGQADAGQDAVQL 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 566 MTLHAAKGLEFPVVFLMGLEEGVFPLSRAMLEESELEEERRLAYVGITRAEEALFLTNAYSRTLYGRTQYNRPSRFLEEI 645
Cdd:TIGR01075 552 MTLHSAKGLEFPLVFLVGMEEGMFPSQMSLDEGGRLEEERRLAYVGITRAMQKLTITYAETRRLYGKEVYHIPSRFIREL 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 646 eaerlmkqgaaanlqkaPARTFDPKVFKPSASKPAYTQPATKSVSNKVASGGekvsWQAGDKVQHKAWGVGTVVRVGGSA 725
Cdd:TIGR01075 632 -----------------PEECLHEVRLRAQVSRPTNLGRVGTPSVDEINDAG----FKLGQRVRHPKFGEGTIINAEGSG 690
|
730 740
....*....|....*....|....*
gi 488291971 726 KDLELDIAFPEKGIKRLLAAFAPIE 750
Cdd:TIGR01075 691 EHSRLQIAFQGQGIKWLVAAYAKLE 715
|
|
| rep |
TIGR01074 |
ATP-dependent DNA helicase Rep; Designed to identify rep members of the uvrD/rep subfamily. ... |
10-655 |
0e+00 |
|
ATP-dependent DNA helicase Rep; Designed to identify rep members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130146 [Multi-domain] Cd Length: 664 Bit Score: 586.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 10 GMNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLLETG-GEDVWV 88
Cdd:TIGR01074 1 KLNPQQQEAVEYVTGPCLVLAGAGSGKTRVITNKIAYLIQNCGYKARNIAAVTFTNKAAREMKERVAKTLGKGeARGLTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 89 STFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKTLMKRILNDLnIDSKKYDPRSILGTISNAKNELQTPEKVAEMQGSLY 168
Cdd:TIGR01074 81 STFHTLGLDIIKREYNALGYKSNFSLFDETDQLALLKELTEGL-IKDDKDLLDKLISTISNWKNDLLTPEQALASARGER 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 169 EEIVAKCYEAYQKELRKNQCMDFDDLIMNTIRLFNEQPDTLAFYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKNLCVV 248
Cdd:TIGR01074 160 EQTFAHCYALYQAHLRAYNALDFDDLILLPTLLLQQNEEVRNRWQNKIRYLLVDEYQDTNTSQYELVKLLVGDRARFTVV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 249 GDADQSIYGWRGADMQNILDFEKDYPDASVILLEQNYRSTKNILAAANDVIKNNRNRREKELWTENIDGEKIVYYRGDTE 328
Cdd:TIGR01074 240 GDDDQSIYSWRGARPENLVLLKEDFPQLKVIKLEQNYRSTGRILKAANILIANNPHVFEKKLFSELGYGEKIKVIECNNE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 329 RDETQFIVSQIQKEMRENDRIYGDFAVLYRTNAQSRVVEEMLLKSNIPYTMVGGHKFYDRKEIKDILAYLSLIANPDDSI 408
Cdd:TIGR01074 320 EHEAERIAGEIIAHKLVNKTQYKDYAILYRGNHQSRLLEKALMQNRIPYKLSGGTSFFSRPEIKDLLSYLRLLVNPDDDA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 409 SFERIVNEPKRGIGKSSIEKLRLFADTHGWALLEAAQNVDL-ANISGKAGKELGNFGMMIQDLTKTVPYLTITELVKETL 487
Cdd:TIGR01074 400 AFLRIVNTPKREIGPATLEKLGELAMERNKSLFTASFDMGLlQTLSGRGYESLQRFTDWLVEIRRLAERSEPIEAVRSLI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 488 QRSGYREALMAQNNLESQA--RLENLDEFLSVTQEFDKRfeaqnnDDPNGEETkLADFLTDLALVSDLDNL--EESSSQV 563
Cdd:TIGR01074 480 EDIDYENWLYETSPSPKAAemRMKNVNTLFSWFKEMLEG------DEEDEPMT-LTQVVTRLTLRDMLERGedEEELDQV 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 564 TLMTLHAAKGLEFPVVFLMGLEEGVFPlSRAMLEESELEEERRLAYVGITRAEEALFLTNAYSRTLYGRTQYNRPSRFLE 643
Cdd:TIGR01074 553 QLMTLHASKGLEFPYVFIVGMEEGILP-HQSSIEEDNVEEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRFLD 631
|
650
....*....|..
gi 488291971 644 EIEAERLMKQGA 655
Cdd:TIGR01074 632 ELPQEDLQWEGD 643
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
11-665 |
1.58e-154 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 464.70 E-value: 1.58e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 11 MNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLL---ETGGedVW 87
Cdd:PRK10919 3 LNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKERVAQTLgrkEARG--LM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 88 VSTFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKTLMKRILNDLnIDSKKYDPRSILGTISNAKNELQTPEKVAEMQGSL 167
Cdd:PRK10919 81 ISTFHTLGLDIIKREYAALGMKSNFSLFDDTDQLALLKELTEGL-IEDDKVLLQQLISTISNWKNDLKTPAQAAAGAKGE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 168 YEEIVAKCYEAYQKELRKNQCMDFDDLIMNTIRLFNEQPDTLAFYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKNLCV 247
Cdd:PRK10919 160 RDRIFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQRNEEVRERWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARFTV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 248 VGDADQSIYGWRGADMQNILDFEKDYPDASVILLEQNYRSTKNILAAANDVIKNNRNRREKELWTENIDGEKIVYYRGDT 327
Cdd:PRK10919 240 VGDDDQSIYSWRGARPQNLVLLSQDFPALQVIKLEQNYRSSGRILKAANILIANNPHVFEKRLFSELGYGDELKVLSANN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 328 ERDETQFIVSQIQKEMRENDRIYGDFAVLYRTNAQSRVVEEMLLKSNIPYTMVGGHKFYDRKEIKDILAYLSLIANPDDS 407
Cdd:PRK10919 320 EEHEAERVTGELIAHHFVNKTQYKDYAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 408 ISFERIVNEPKRGIGKSSIEKLRLFADTHGWALLEAAQNVDLA-NISGKAGKELGNFGMMIQDLTKTV---PYLTITELV 483
Cdd:PRK10919 400 SAFLRIVNTPKREIGPATLQKLGEWAMTRNKSLFTASFDMGLSqTLSGRGYESLTRFTHWLAEIQRLAerePVAAVRDLI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 484 KETLQRSGYREALMAQNNLEsqARLENLDEFLSVTQEFdkrFEAQNNDDPngeeTKLADFLTDLALVSDLDNLE--ESSS 561
Cdd:PRK10919 480 HGIDYESWLYETSPSPKAAE--MRMKNVNQLFSWMTEM---LEGSELDEP----MTLTQVVTRFTLRDMMERGEseEELD 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 562 QVTLMTLHAAKGLEFPVVFLMGLEEGVFPLSRAMlEESELEEERRLAYVGITRAEEALFLTNAYSRTLYGRTQYNRPSRF 641
Cdd:PRK10919 551 QVQLMTLHASKGLEFPYVYLVGMEEGLLPHQSSI-DEDNIDEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRF 629
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 488291971 642 LEE--------------IEAERLMKQGAA--ANLQKAPAR 665
Cdd:PRK10919 630 LLElpqddliweqerkvVSAEERMQKGQShlANLKAMLAA 669
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
11-274 |
3.76e-121 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 363.87 E-value: 3.76e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 11 MNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLL-ETGGEDVWVS 89
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERILKLLgKAELSELNIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 90 TFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKTLMKRILNDL--NIDSKKYDPRSILGTISNAKNELQTPEKVAEMQGSL 167
Cdd:pfam00580 81 TFHSFCLRILRKYANRIGLLPNFSILDELDQLALLKELLEKDrlNLDPKLLRKLELKELISKAKNRLLSPEELQQGAADP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 168 YEEIVAKCYEAYQKELRKNQCMDFDDLIMNTIRLFNEQPDTLAFYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKNLCV 247
Cdd:pfam00580 161 RDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHENLFL 240
|
250 260
....*....|....*....|....*..
gi 488291971 248 VGDADQSIYGWRGADMQNILDFEKDYP 274
Cdd:pfam00580 241 VGDPDQSIYGFRGADIENILKFEKDFP 267
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
11-622 |
9.40e-97 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 319.22 E-value: 9.40e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 11 MNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERV--------------- 75
Cdd:COG1074 6 WTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIrerlaeaadledpdl 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 76 ----------NKLLETGGEdVWVSTFHSMCVRILRRDVDQIGYNRNFTIIDPSEQkTLMKRILNDLnIDSKKYDP----- 140
Cdd:COG1074 86 eelararrrlARALENLDR-AAISTIHSFCQRLLREFAFEAGLDPNFELLDDAEA-LLLEEAVDDL-LREAYAPLdalal 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 141 --------------RSILGTISNAKNELQTPEKVAEMQGSLYE-------------------------------EIVAKC 175
Cdd:COG1074 163 arlldafgrdddslEELLLALYKLRSRPDWLEELAELDEALEAlreallkakealaalrealaaaaapllaallRLLAAV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 176 YEAYQKELRKNQCMDFDDLIMNTIRLF-NEQPDTLAF-YQNKFHYIHVDEYQDTNHAQYTLVNLLAARFK----NLCVVG 249
Cdd:COG1074 243 LARYERRKRERGLLDFDDLLHRALRLLrDEDAPWVAErLRERYRHILVDEFQDTSPLQWEILRRLAGEALadgrTLFLVG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 250 DADQSIYGWRGADMQNILDFEKDY---PDASVILLEQNYRSTKNILAAANDVIKNNRNRREKE----------------- 309
Cdd:COG1074 323 DPKQSIYRFRGADPELFLEARRALegrVDGERLTLTTNFRSTPEVVDAVNALFAQLMGAGFGEipyepvealrpgaypav 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 310 --LWTENIDGEKivyyrGDTERDETQFIVSQIQKEMRENDRI--------YGDFAVLYRTNAQSRVVEEMLLKSNIPYTM 379
Cdd:COG1074 403 elWPLEPDDVSE-----EDAREREARAVAARIRRLLAEGTTVegggrpvrPGDIAVLVRTRSEAAAIARALKAAGIPVAA 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 380 VGGHKFYDRKEIKDILAYLSLIANPDDSISFERIVNEPkrGIGKSSIEKLRLFADTHGWALLEAAQNVDlanisgkagkE 459
Cdd:COG1074 478 SDRLSLFESPEVRDLLALLRALLNPEDDLALAAVLRSP--LFGLSDEDLAALAADRKGESLWEALRAYE----------R 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 460 LGNFGMMIQDLTKTVPYLTITELVKETLQRSGYREALMAQNNLE-SQARLENLDEFLSVTQEfdkrFEAQNNDDpngeet 538
Cdd:COG1074 546 LARALERLRALRELARRLGLAELLERLLEETGLLERLLALPGGErRLANLLHLDELLQLALE----YEQTGGPG------ 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 539 kLADFLTDLALVSDLDN------LEESSSQVTLMTLHAAKGLEFPVVFLmgleegvfPLSRAMLEESELEEERRLAYVGI 612
Cdd:COG1074 616 -LAGFLRWLERLIEDGGdeekrrLESDADAVRIMTIHKSKGLEFPVVFL--------PALRERARAEELAEELRLLYVAL 686
|
730
....*....|
gi 488291971 613 TRAEEALFLT 622
Cdd:COG1074 687 TRARDRLVLS 696
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
12-285 |
2.10e-94 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 291.73 E-value: 2.10e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 12 NPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLL-ETGGEDVWVST 90
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPPERILAVTFTNKAAKEMRERLRKLLgEQLASGVWIGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 91 FHSMCVRILRRDVDqigynrnftiidpseqktlmkrilndlnidskkydprsilgtisnaknelqtpekvaemqgslyee 170
Cdd:cd17932 81 FHSFALRILRRYGD------------------------------------------------------------------ 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 171 ivakcyeayqkelrknqcmdFDDLIMNTIRLFNEQPDTLAFYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKNLCVVGD 250
Cdd:cd17932 95 --------------------FDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDGKNLFVVGD 154
|
250 260 270
....*....|....*....|....*....|....*
gi 488291971 251 ADQSIYGWRGADMQNILDFEKDYPDASVILLEQNY 285
Cdd:cd17932 155 DDQSIYGFRGADPENILDFEKDFPDAKVIKLEENY 189
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
279-622 |
1.94e-83 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 270.05 E-value: 1.94e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 279 ILLEQNYRSTKNILAAANDVIKNNRNRR----EKELWTENIDGEKIVYYRGDTERDETQFIVSQIQKEMRENDRiYGDFA 354
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNFGRAtiypKKILAETVEDGEKIKIIEAETEEEEAEWIALEIKKLVARDEK-YNDIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 355 VLYRTNAQSRVVEEMLLKSNIPYTMVGGHKFYDRKEIKDILAYLSLIANPDDSISFERIVNEPKRGIGKSSIEKLRL--- 431
Cdd:pfam13361 80 VLTRSNSDADLIEEALKKLGIPYFVVGQTKFFRREEIKDILAYLRLIANKHDSISLKRILNGPKRGIGNATLERIREykk 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 432 ---------------FADTHGWALLEAAQ----------NVDLANISGKAGKELGNFGMMIQDLTKtvpYLTITELVKET 486
Cdd:pfam13361 160 rglrlsdfinpdtltYGDPFVIALEQDNIvvfdvettglDTTEDEIIQIAAIKLNKKGVVIESFER---FLRLKKPVGDS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 487 LQRSGYREALMAQNNLESQA-------RLENLDEFLSVTQEFDKRFEaqnnddPNGEETKLADFLTDLALVSDLDNLEES 559
Cdd:pfam13361 237 LQVHGFSDEFLQENGETPAEalrdfleKLENLRELYSILREYDDIEE------TPEPEDALRNFLEIATLSNSELEGSDI 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488291971 560 SSQVTLMTLHAAKGLEFPVVFLMGLEEGVFPLSRAMLEESELEEERRLAYVGITRAEEALFLT 622
Cdd:pfam13361 311 KERIPIMTIHQAKGLEFDTVFLAGLEEGIFPSYRSIKDEGNLEEERRLFYVAITRAKKRLYIS 373
|
|
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
13-584 |
1.84e-31 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 132.13 E-value: 1.84e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 13 PRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIaylIEE--KEVNPWNILAITFTNKAAKEMKERV----NKLLETGGEDV 86
Cdd:TIGR02785 4 DEQWQAIYTRGQDILVSASAGSGKTAVLVERI---IRKitRGVDVDRLLVVTFTNAAAREMKERIaealEKELVQEPNSK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 87 WV------------STFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKTLMKRILNDL------------------NIDSK 136
Cdd:TIGR02785 81 HLrrqlallntaniSTLHSFCLKVIRKHYYLLDLDPSFRILTDTEQLLLIKEVLDDVfeeeyykedkeaffelvdNFSGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 137 KYD-------------------PRS-----------------------------ILGTISNAKNELQ----------TPE 158
Cdd:TIGR02785 161 RSDdglrdlilqlydfsrstpnPEKwlnnlaeayevkekftieslklqqqikelLKNELEGLQEKLQralelfmaedGLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 159 KVAEM-------QGSLYEEIVAKCY------------------------------------------------------- 176
Cdd:TIGR02785 241 PRLENfqldlqnIDELIQESLAQADwnelrkavaafkfknlkaakgdeedadlleeadklreeakkqleklktdyftrse 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 177 -------------------------EAYQKELRKNQCMDFDDLIMNTIRLFNEQPDT----LAFYQNKFHYIHVDEYQDT 227
Cdd:TIGR02785 321 edhlrimqemkpvvktlvqlvkdfiERFGAEKREKNILDFSDLEHYALQILTNENESpseaAEFYREKFHEVLVDEYQDT 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 228 NHAQYTLVNLLAARFK---NLCVVGDADQSIYGWRGADMQNILDFEKDYPDAS-----VILLEQNYRSTKNILAAANDVI 299
Cdd:TIGR02785 401 NLVQESILQLVKRGPEeegNLFMVGDVKQSIYRFRQADPLLFLEKYHRFAQEGeehgkRIDLAENFRSRAEVLDTTNFLF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 300 KNNRNRR--------EKEL------WTENID--GEKIVYYRGDTERDE-------------TQF----IVSQIQKEMREN 346
Cdd:TIGR02785 481 KQLMDEEvgeidydeEAQLkfgaakYPENPDnkTEELLYEKLLIEEAEeeeideeaeildkAQQeatmVAERIKALIKEG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 347 DRI------------YGDFAVLYRTNAQSRVVEEMLLKSNIPYTMVGGHKFYDRKEIKDILAYLSLIANPDDSISFERIV 414
Cdd:TIGR02785 561 FKVydkktgtyrpvtYRDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQDIPLVAVL 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 415 NEPKRGIGKSSIEKLRLFADTHGWalLEAAQNVdlaNISGKAGKELG----NFGMMIQDLTKTVPYLTITELVKETLQRS 490
Cdd:TIGR02785 641 RSPIVGFDENELALIRLENKDSSY--YEAVKDY---VKAGLIEDELYeklnTFLDSLQKWREFARTHSVSELIWKIYNDT 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 491 GYREALMAQ-NNLESQARLENL----DEFLSVTqeFDKRFEAQNNDDpngeetKLADFLTDLA---LVSDLDNLeesssq 562
Cdd:TIGR02785 716 GYYDYVGGLpGGKQRQANLYALyeraRQYESTS--FKGLFQFIRFIE------RMQERQKDLAsavAVGEAENA------ 781
|
810 820
....*....|....*....|..
gi 488291971 563 VTLMTLHAAKGLEFPVVFLMGL 584
Cdd:TIGR02785 782 VRLMTIHKSKGLEFPVVFVLGM 803
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
11-310 |
6.99e-28 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 119.67 E-value: 6.99e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 11 MNPRQEEAVLHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKERVNKLLetGGEDVWVST 90
Cdd:PRK11054 197 LNPSQARAVVNGEDSLLVLAGAGSGKTSVLVARAGWLLARGQAQPEQILLLAFGRQAAEEMDERIRERL--GTEDITART 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 91 FHSMCVRILRR-------------DVDQigyNRNFTIID----PSEQKTLMKR----ILNDLNID----SKKYDPR---- 141
Cdd:PRK11054 275 FHALALHIIQQgskkvpvisklenDSKA---RHALLIAEwrkqCSEKKAQAKGwrqwLTEELQWDvpegNFWDDEKlqrr 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 142 ---------SILGTISNAKNEL--QTPEKVAE-MQGSLyeEIVAKCYEAYQKELRKNQCMDFDDLIMNTIRLFNEqpdtl 209
Cdd:PRK11054 352 lasrlerwvSLMRMHGGSQAEMiaQAPEEVRDlFQKRL--KLMAPLLKAWKKALKAENAVDFSGLIHQAVNYLEK----- 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 210 afyqNKF----HYIHVDEYQDTNHAQYTLvnLLAARFKN----LCVVGDADQSIYGWRGADMQNILDFEKDYPDASVILL 281
Cdd:PRK11054 425 ----GRFispwKHILVDEFQDISPQRAAL--LAALRKQNsqttLFAVGDDWQAIYRFSGADLSLTTAFHERFGEGDRCHL 498
|
330 340
....*....|....*....|....*....
gi 488291971 282 EQNYRSTKNILAAANDVIKNNRNRREKEL 310
Cdd:PRK11054 499 DTTYRFNSRIGEVANRFIQQNPHQLKKPL 527
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
27-646 |
6.12e-26 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 114.46 E-value: 6.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 27 LVMAGAGSGKTRVLTHRIAYLIEEKEvnpwNILAITFTNKAAKEMKERVNKLLETGGEDVWVSTFHSMCVRILRrdvDQI 106
Cdd:COG3857 2 FILGRAGSGKTTYLLEEIKEELKEGK----PIILLVPEQMTFQAERALLKRLGLGGSIRAQVLSFSRLAWRVLQ---ETG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 107 GYNRnfTIIDPSEQKTLMKRILNDLNIDSKKYDP--------RSILGTISNAKNELQTPEKVAEMQGSLYE--EIVAKCY 176
Cdd:COG3857 75 GATR--PLLSDAGKRMLLRKILEEHKDELKVFARaadkpgfiEQLAELITELKRYGITPEDLEEAAELLKEklRDLALIY 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 177 EAYQKELRKNQcMDFDDLImntiRLFNEQPDTLAFYQNkfHYIHVDEYQDTNHAQYTLVNLLAARFKNLCVVGDADQSIY 256
Cdd:COG3857 153 EAYEEKLAGRY-IDSEDLL----RLLAEKLEKSEFLEG--AEIYIDGFTDFTPQELELLEALLKKAKEVTITLTLDPDEL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 257 GWRGADMQNILDFEKDypdASVILLEQNYRSTKNILAaandvIKNNRNRREKELWTENIdgeKIvyYRGDTERDETQFIV 336
Cdd:COG3857 226 DLFSATGETYERLLEL---AKENGVEVEFKKSPELAH-----LERNLFAYPPEEEPEGI---EI--IEAANRRAEVEAVA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 337 SQIQKEMRENDRIYGDFAVLYR-TNAQSRVVEEMLLKSNIPYtmvgghkFYDRKE-------IKDILAYLSLIANPDDSI 408
Cdd:COG3857 293 REIRRLVREEGYRYRDIAVVVRdLEAYAPLIERVFAEYGIPY-------FIDEKRplshhplVELILSLLELVRSNFRYE 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 409 SFERIV-NEPKRGIGKSSIEKLRLFADTHG-------------WALLEAAQNVDLANISGKAGKELGNFGMMIQDLTKTV 474
Cdd:COG3857 366 DVFRLLkTGLLRPLSREEIDRLENYVLAYGirgrrwleryleeEEELTDEEEEDLERLNELRDRLLEPLLPLRERLKKAK 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 475 PYLTITELVKETLQRSGYREALMAQNNLESQARLENLDEFLSVTQEFDKRFEaQNNDDPNGEETKLADFLTDLALVsdLD 554
Cdd:COG3857 446 TVREWAEALYEFLEELGVPEKLEEWREAEEAGDLEEAREHEQAWNALIELLD-ELVEVLGDEKLSLEEFLRILESG--LE 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 555 NLE-----ESSSQVTLMTLHAAKGLEFPVVFLMGLEEGVFPLSR---------------------AMLEESELEEERRLA 608
Cdd:COG3857 523 ELTfglipPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPredgllsdeererlnelglelPPTSRERLLEERFLF 602
|
650 660 670
....*....|....*....|....*....|....*....
gi 488291971 609 YVGITRAEEALFLTnaYSRTLY-GRTQynRPSRFLEEIE 646
Cdd:COG3857 603 YRALTRASERLYLS--YPLADEeGKAL--LPSPLIDRLR 637
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
287-370 |
1.33e-23 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 97.30 E-value: 1.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 287 STKNILAAANDVIKNNRNRREKELWTENIDGEKIVYYRGDTERDETQFIVSQIQKEMRENDRIYGDFAVLYRTNAQSRVV 366
Cdd:cd18807 1 STKNILDAANSLIKQNKNRPKKPLKAGNKSGGPVELLLAKDEADEAKAIADEIKRLIESGPVQYSDIAILVRTNRQARVI 80
|
....
gi 488291971 367 EEML 370
Cdd:cd18807 81 EEAL 84
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
177-622 |
1.59e-23 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 106.70 E-value: 1.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 177 EAYQKELRKNQCMDFDDLIMNTIRLFNEqPDTLAFYQNKFH----YIHVDEYQDTNHAQYTLVNLLAARF---------- 242
Cdd:TIGR02784 349 QRYARLKKARGLLDFNDLIERTVALLAR-PGAGAWVHYKLDrgidHILVDEAQDTSPEQWDIIQALAEEFfsgegarsgv 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 243 -KNLCVVGDADQSIYGWRGADMQNILD----FEKDYPDASV----ILLEQNYRSTKNILAAANDVIKNNRNRR------- 306
Cdd:TIGR02784 428 eRTIFAVGDEKQSIYSFQGADPERFAEerreFSRKVRAVGRkfedLSLNYSFRSTPDVLAAVDLVFADPENARglsadsd 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 307 -------------EKELW-------TENIDGEKIVYyrgDTERDET------QFIVSQIqKEMRENDRI---------YG 351
Cdd:TIGR02784 508 apvheafrddlpgRVDLWdliskeeGEEPEDWTDPV---DELGERApevrlaERIAAEI-RAWLDRGTPipgrgravrPG 583
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 352 DFAVLYRTnaQSRVVEEML--LKS-NIPytmVGGhkfYDR----KEI--KDILAYLSLIANPDDSISFERIVNEPKRGIG 422
Cdd:TIGR02784 584 DILVLVRK--RDAFFSALIraLKRrGIP---VAG---ADRlkltSHIavKDLMALGRFVLQPEDDLSLAALLKSPLFGLD 655
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 423 KSsieklRLFADTHG------WALLeaaqnvdlanisGKAGKELGNFGMMIQDLTKTVPYLTITELVKETLQRSGYREAL 496
Cdd:TIGR02784 656 ED-----DLFRLAAGrsggslWAAL------------RRREAEFAATLAVLRDWLSLADFLTPFEFYARLLGRDGGRRKL 718
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 497 MAQnnLESQARlENLDEFLSVTQEFdkrfeaqnnddpngEETKLADFltdLALVSDLDN--------LEESSSQVTLMTL 568
Cdd:TIGR02784 719 LAR--LGAEAE-DILDEFLSQALAY--------------ERTGLPGL---QAFLSWLEAddpeikreMDQARDEVRVMTV 778
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 569 HAAKGLEFPVVFLM------------------GLEEGVFPLSRAMLEESELEEERRLA--------------YVGITRAE 616
Cdd:TIGR02784 779 HGAKGLEAPVVFLVdtgskpfasqraplllatGGSGGKAPLWRPASAFDPSLSAAARErlkeraedeyrrllYVAMTRAE 858
|
....*.
gi 488291971 617 EALFLT 622
Cdd:TIGR02784 859 DRLIVC 864
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
25-285 |
1.61e-21 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 90.62 E-value: 1.61e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 25 PLLVMAGAGSGKTRVLTHRIAYLIEEKEVNPWNILAITFTNKAAKEMKervnklletggedvwvstfhsmcvrilrrdvd 104
Cdd:cd17914 1 LSLIQGPPGTGKTRVLVKIVAALMQNKNGEPGRILLVTPTNKAAAQLD-------------------------------- 48
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 105 qigynrnftiidpseqktlmkrilndlnidskkydprsilgtisnaknelqtpekvaemqgslyeeivakcyeayqkelr 184
Cdd:cd17914 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 185 knqcmdfddlimntirlfneqpdtlafyqnkfhYIHVDEYQDTNHAQYTLVNLLAARFKNLCVVGDADQSIYGWRGADMQ 264
Cdd:cd17914 49 ---------------------------------NILVDEAAQILEPETSRLIDLALDQGRVILVGDHDQLGPVWRGAVLA 95
|
250 260
....*....|....*....|....*.
gi 488291971 265 N-----ILDFEKDYPDASVILLEQNY 285
Cdd:cd17914 96 KicneqSLFTRLVRLGVSLIRLQVQY 121
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
29-582 |
1.38e-17 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 87.72 E-value: 1.38e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 29 MAGAGSGKTRVLTHRIAYLIEeKEVNPWNILAITFTNKAAKEMKERVNKLLETGGE------------------------ 84
Cdd:PRK13909 4 KASAGSGKTFALSVRFLALLF-KGANPSEILALTFTKKAANEMKERIIDTLLNLEKekeeselneleeklglskeellnk 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 85 -----------DVWVSTFHSMCVRILRRDVDQIGYNRNFTIIDPSEQKtLMKRILNDLN--------------------- 132
Cdd:PRK13909 83 rdkvyqeflnsELKISTIDAFFQKILRKFCLNLGLSPDFSIKEDTKEE-LNEKFLSALSkeellellafikqceskknns 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 133 -----------------IDSKKYDP------------------RSILGTISNAKNELQT-------------PEKVAEMQ 164
Cdd:PRK13909 162 ffelleklyeknnelklFEKAKNPIefdeekfleelrslkqqiQSIETASKNAKKAFKKedfeellnssktwLEKESEYR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 165 G----------SLYEEI------------------VAKCYEAYQKEL----RKNQCMDFDDlIMNTIR--LFNEQPDTLA 210
Cdd:PRK13909 242 YfkklyneeldAEFEELknalkryydakenyklskLFKLLQLYKEAKnelnKKKNALDFDD-ISKKVYelLGEEEIDKDF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 211 FY---QNKFHYIHVDEYQDTNHAQYT-LVNLLA--------ARFKNLCVVGDADQSIYGWRGADMQNILDFEKDYPDASV 278
Cdd:PRK13909 321 LYfrlDSKISHILIDEFQDTSVLQYKiLLPLIDeiksgegqKKFRSFFYVGDVKQSIYRFRGGKKELFDKVSKDFKQKVD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 279 IlLEQNYRSTKNILAAANDVIKNNRNRREKELWTENIDGEKIVYYRGDTERDET-QFIVSQIQkEMRENDRIYGDFAVLY 357
Cdd:PRK13909 401 N-LDTNYRSAPLIVDFVNEVFKKKYKNYKTQYAEQHKSGGYVEVVEVADESEELlEQLLQEIQ-FLLEKGIDPDDIAILC 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 358 RTNAQSRVVEEMLLKS-NIPYTMVGGHKFYDRKEIKDILAYLslianpddsisferivnepkrgigkssieKLRLFADth 436
Cdd:PRK13909 479 WTNDDALEIKEFLQEQfGIKAVTESSAKLINQPEVKALIEAL-----------------------------KYCLFGE-- 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 437 gwalleaaqNVDLANISGKAGKELGNFGMMIqDLTKTVPyltitELVKETLQRSGYREAlMAQNNLESQARLENLDEFLS 516
Cdd:PRK13909 528 ---------EIYKHNVLKLLGKEPDKIPSFL-PKEESVA-----EFVKKLIEELKLYDE-NLLKFLELASGYEDIEEFLF 591
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488291971 517 VTQEFDKRFEAQNNDDpngeetkladfltdlalvsdldnleesssqVTLMTLHAAKGLEFPVVFLM 582
Cdd:PRK13909 592 KLEPCDKEIASEESKG------------------------------VQIMTVHKSKGLEFEHVIVC 627
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
15-94 |
2.44e-17 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 79.18 E-value: 2.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 15 QEEAV--LHTEGPLLVMAGAGSGKTRVLTHRIAYLIEEKEVnPWNILAITFTNKAAKEMKERvnklleTGGEdvwVSTFH 92
Cdd:pfam13245 1 QREAVrtALPSKVVLLTGGPGTGKTTTIRHIVALLVALGGV-SFPILLAAPTGRAAKRLSER------TGLP---ASTIH 70
|
..
gi 488291971 93 SM 94
Cdd:pfam13245 71 RL 72
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
24-406 |
1.47e-12 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 71.05 E-value: 1.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 24 GPLLVMAGAGSGKTRVLTHRIAYL-------IEEKEV-----NP---------------WNILAITFTnkaakEMKERVN 76
Cdd:COG3973 206 GVLVVQGGAGSGKTAVALHRAAYLlythrerLERGGVlivgpNRlfldyisqvlpslgeEGVVQTTFG-----DLVPELL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 77 KLLETGGEDVWVSTF-HSM-CVRILRRDVDQ---------IGYNRNFTIIDPSEQKTLMKRILNDLNIDSKKYDPRSILG 145
Cdd:COG3973 281 GVEATAEEDPEVARLkGSLrMAEVLDRAVRDlerevpfedIRVEGGEVILSAEEIAEAFYRARRSLPHNKRRERLRERLL 360
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 146 TISNAKNELQTPEKVAEMQGSLYEEIVAKcyeayqKELRK--NQCMDFDDlIMNTIRLFNEQPDTLAFY----------- 212
Cdd:COG3973 361 DALKDQLAAELGKLWDEERDELRRELRRS------KPVRAalNRLWPFLD-PAELYRDLFSDPELLARAagwlspeeral 433
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 213 ---------------------------------QNKFHYIHVDEYQDTNHAQYtlvNLLAARFKN--LCVVGDADQSIYG 257
Cdd:COG3973 434 llrptrelkkgrwtvadvalldelaellggpdrTWTYGHVVVDEAQDLSPMQW---RVLKRRFPSasFTIVGDLAQAIHP 510
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 258 WRGA-DMQNILD-FEKDypDASVILLEQNYRSTKNILAAANDVIKNNRN--------RRekelwteniDGEKIVYYRGDT 327
Cdd:COG3973 511 YRGAeSWEEVLEpLGGD--RARLVELTKSYRSTAEIMEFANRVLRAAGPdlpppesvRR---------HGEPPRVVRVPS 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 328 ERDETQFIVSQIqKEMRENDriYGDFAVLYRTNAQSRVVEEmLLKSNIPYTMVGGHKFYDRKEIKDILAYLS-------- 399
Cdd:COG3973 580 EAELAAAVVEAV-RELLAEG--EGTIAVICKTAREAEALYA-ALKAGLPVTLIDDESEELEAGVVVLPAYLAkglefdav 655
|
....*..
gi 488291971 400 LIANPDD 406
Cdd:COG3973 656 VVVDPDE 662
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
15-392 |
1.44e-11 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 67.55 E-value: 1.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 15 QEEAVLHT-EGPLLVMAGAGSGKTRVLTHRIAYLIEEkevNP-WNILaITFTNKA-AKEMKERVNK-LLETGGEDVW--- 87
Cdd:COG3972 164 QERIARSIpDGPQRIRGVAGSGKTVLLAAKAAYLALK---HPgWRIL-VTCFNRSlADHLRDLIPRfLRRFSNGEPEdnv 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 88 -VSTFHSMCVRILRRdvdqigynrnftiidpseqktlmkrilndLNIDSKKYdprsilgtisnaknelqtpekvaemqgs 166
Cdd:COG3972 240 kLIVFHAWGGKLLKQ-----------------------------YGIPPLTF---------------------------- 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 167 lyeeivakcyeAYQKELRKNQCMDFDDLIMNTIRLFneqpdtlafyqnKFHYIHVDEYQDTNHAQYTLV-NLLAARFKNL 245
Cdd:COG3972 263 -----------SQPNEAFDEACKALLEAIQGEIIPP------------IYDAILIDEAQDFEPEFLRLLyQLLKPPKKRL 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 246 CVVGDADQSIYGWRGADMQNIldfeKDYPDASVIlLEQNYRSTKNILAAANDVIKNNRN-----RREKELWTENIDGEKI 320
Cdd:COG3972 320 IWAYDEAQNIYGRKIPSAGGI----PAGIGRDTI-LKKNYRNTRPILTFAHAFGMGLLRppgllQGDAEDYEVERPGDKV 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 321 VYYRG----------------DTERDETQFIVSQIQKEMRENDRIYGDFAVLYRTNAQSR----VVEEMLLKSNIPYTMV 380
Cdd:COG3972 395 TLIRPpepagrkgplpefkkyDDRAEELEAIAEEIKKNLRDEGLRPSDIAVIYLGNNEAKelgdRLAAALERQGIDSYIA 474
|
410
....*....|....*.
gi 488291971 381 GG----HKFYDRKEIK 392
Cdd:COG3972 475 GArsdpNFFWKDGGVT 490
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
537-632 |
2.17e-08 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 57.53 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 537 ETKLADFL------TDLALVSDLDNLEESSSQVTLMTLHAAKGLEFPVVFLMGLEEgvfplsraMLEESELEEERRLAYV 610
Cdd:COG3972 457 GDRLAAALerqgidSYIAGARSDPNFFWKDGGVTISTIHRAKGLEAPVVIIVGLDQ--------LAKGESLERLRNLLYV 528
|
90 100
....*....|....*....|....
gi 488291971 611 GITRAEEALFLT--NAYSRTLYGR 632
Cdd:COG3972 529 AMTRARGWLVVSgsGESMAELYDE 552
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
534-622 |
7.24e-07 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 47.82 E-value: 7.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 534 NGEETKLADFLTDLALvsdldnLEESSSQVTLMTLHAAKGLEFPVVFLMGLEEGVFPLSRamleeseleeerrlAYVGIT 613
Cdd:cd18786 20 HRDRAYLNQYLQGLSL------DEFDLQLVGAITIDSSQGLTFDVVTLYLPTANSLTPRR--------------LYVALT 79
|
....*....
gi 488291971 614 RAEEALFLT 622
Cdd:cd18786 80 RARKRLVIY 88
|
|
| DEAD-like_helicase_N |
cd17912 |
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
26-71 |
1.51e-05 |
|
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.
Pssm-ID: 350670 [Multi-domain] Cd Length: 81 Bit Score: 43.66 E-value: 1.51e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 488291971 26 LLVMAGAGSGKTRVLTHRIAYLIeekeVNPWNILAITFTNKAAKEM 71
Cdd:cd17912 2 ILHLGPTGSGKTLVAIQKIASAM----SSGKSVLVVTPTKLLAHEI 43
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
563-622 |
7.66e-05 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 40.64 E-value: 7.66e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488291971 563 VTLMTLHAAKGLEFPVVFL---MGLEEGVFPLSRAMLeeseleeerrlaYVGITRAEEALFLT 622
Cdd:pfam13538 2 AYALTVHKAQGSEFPAVFLvdpDLTAHYHSMLRRRLL------------YTAVTRARKKLVLV 52
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
12-94 |
1.54e-03 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 41.89 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 12 NPRQEEAV---LHTEGPLLVMAGAGSGKTRVLtHRIAYLIEEKEvnpWNILAITFTNKAAKEMKErvnkllETGGEdvwV 88
Cdd:COG0507 126 SDEQREAValaLTTRRVSVLTGGAGTGKTTTL-RALLAALEALG---LRVALAAPTGKAAKRLSE------STGIE---A 192
|
....*.
gi 488291971 89 STFHSM 94
Cdd:COG0507 193 RTIHRL 198
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
177-296 |
6.78e-03 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 39.95 E-value: 6.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488291971 177 EAYQKELRKNQCMDFDDLIMNTIR-LFNEQPDTLA-FYQNKFHYIHVDEYQDTNHAQYTLVNLLAARFKN--LCVVGDAD 252
Cdd:PRK10876 337 ETVAQEKRRRGELGFDDLLSRLDSaLQSEGGEALAaAIRTRYPVAMIDEFQDTDPQQYRIFRRIYRHQPEtaLLLIGDPK 416
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 488291971 253 QSIYGWRGADmqnILDFEKDYPDASV-ILLEQNYRSTKNILAAAN 296
Cdd:PRK10876 417 QAIYAFRGAD---IFTYMKARSEVSAhYTLDTNWRSAPGMVNSVN 458
|
|
| SF1_C_RecD |
cd18809 |
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
566-621 |
8.46e-03 |
|
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 36.00 E-value: 8.46e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 488291971 566 MTLHAAKGLEFPVVFLMgLEEGVFPLSRAMleeseleeerrlAYVGITRAEEALFL 621
Cdd:cd18809 36 MTIHKSQGSEFDRVIVV-LPTSHPMLSRGL------------LYTALTRARKLLTL 78
|
|
| |
