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Conserved domains on  [gi|488293147|ref|WP_002364355|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Enterococcus]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-76 6.13e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 61.55  E-value: 6.13e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488293147   1 MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDD 76
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIerGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEEE 83
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-76 6.13e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 61.55  E-value: 6.13e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488293147   1 MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDD 76
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIerGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEEE 83
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-59 3.43e-12

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 56.41  E-value: 3.43e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488293147   5 ERIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYL 59
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIenGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
6-59 1.32e-09

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 49.82  E-value: 1.32e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 488293147     6 RIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYL 59
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIenGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 7-59 9.37e-09

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 47.54  E-value: 9.37e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 488293147    7 IKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYL 59
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIenGKREPSLETLKKLAEALGVSLDEL 55
PHA01976 PHA01976
helix-turn-helix protein
 6-63 1.71e-04

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 36.86  E-value: 1.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488293147   6 RIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYLLGRT 63
Cdd:PHA01976   6 QLIKARNARAWSAPELSRRAGVRHSLIYDFeaDKRLPNLKTLLRLADALGVTLDWLCGRC 65
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-76 6.13e-14

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 61.55  E-value: 6.13e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488293147   1 MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDD 76
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIerGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEEE 83
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-59 3.43e-12

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 56.41  E-value: 3.43e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 488293147   5 ERIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYL 59
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIenGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
6-59 1.32e-09

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 49.82  E-value: 1.32e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 488293147     6 RIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYL 59
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIenGKRKPSLETLKKLAKALGVSLDEL 56
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-64 2.93e-09

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 49.08  E-value: 2.93e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488293147   1 MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYLLGRTE 64
Cdd:COG1476    3 KKLGNRLKELRKERGLTQEELAELLGVSRQTISAIenGKYNPSLELALKIARALGVSLEELFSLEE 68
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 7-59 9.37e-09

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 47.54  E-value: 9.37e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 488293147    7 IKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYL 59
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIenGKREPSLETLKKLAEALGVSLDEL 55
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 5-60 2.71e-07

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 44.20  E-value: 2.71e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 488293147    5 ERIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYLL 60
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIenGKSVPPAETLYKIAELLGVPANWLL 59
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 6-60 3.05e-06

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 41.37  E-value: 3.05e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 488293147    6 RIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSS---DKLEAVANYFNVSVDYLL 60
Cdd:pfam13443   1 KLRKLMADRGISKSDLARATGISRATLSRLRKGKPKRvslDTLDKICDALGCQPGDLL 58
PHA01976 PHA01976
helix-turn-helix protein
 6-63 1.71e-04

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 36.86  E-value: 1.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488293147   6 RIKKLAKDRDVSIYQLEEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYLLGRT 63
Cdd:PHA01976   6 QLIKARNARAWSAPELSRRAGVRHSLIYDFeaDKRLPNLKTLLRLADALGVTLDWLCGRC 65
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 5-75 1.86e-04

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 38.95  E-value: 1.86e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 488293147   5 ERIKKLAKDRDVSIYQL-----EEEINIGRNTIYQW--NKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSD 75
Cdd:PRK13355   6 ERLKQAMKARGLKQEDLvhaaeARGVKLGKSHISQYvsGKTGPRRDVLPFLAAILGVSEDWLLGGESPADQESDASAV 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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