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Conserved domains on  [gi|488294023|ref|WP_002365231|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Enterococcus]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-102 1.14e-26

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 94.93  E-value: 1.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294023   2 DKNVEKKCPVEALSNILGKKWVPQIIESLNGGSMRFGEVCRLLPNSSPKMIKQQLKLLEDNEIVknEKEVFNNT-TSSTY 80
Cdd:COG1733    3 KDLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLV--ERTVYPEVpPRVEY 80

                         90       100
                 ....*....|....*....|..
gi 488294023  81 YLSEKGKDLATIVLQMKLWGQR 102
Cdd:COG1733   81 SLTEKGRSLLPVLDALAEWGEE 102
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-102 1.14e-26

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 94.93  E-value: 1.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294023   2 DKNVEKKCPVEALSNILGKKWVPQIIESLNGGSMRFGEVCRLLPNSSPKMIKQQLKLLEDNEIVknEKEVFNNT-TSSTY 80
Cdd:COG1733    3 KDLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLV--ERTVYPEVpPRVEY 80

                         90       100
                 ....*....|....*....|..
gi 488294023  81 YLSEKGKDLATIVLQMKLWGQR 102
Cdd:COG1733   81 SLTEKGRSLLPVLDALAEWGEE 102
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 17-105 1.71e-17

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 70.79  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294023   17 ILGKKWVPQIIESLNGGSMRFGEVCRLLPNSSPKMIKQQLKLLEDNEIVknEKEVFNNTTSSTYY-LSEKGKDLATIVLQ 95
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGII--NREVYPEVPPKVEYsLTEKGRSLEPILQE 78

                          90
                  ....*....|
gi 488294023   96 MKLWGQRELD 105
Cdd:pfam01638  79 LCDWGEEYLE 88
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-70 1.28e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 1.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 488294023    25 QIIESLNGGSMRFGEVCRLLpNSSPKMIKQQLKLLEDNEIVKNEKE 70
Cdd:smart00418   1 KILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESRRE 45
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
2-102 1.14e-26

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 94.93  E-value: 1.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294023   2 DKNVEKKCPVEALSNILGKKWVPQIIESLNGGSMRFGEVCRLLPNSSPKMIKQQLKLLEDNEIVknEKEVFNNT-TSSTY 80
Cdd:COG1733    3 KDLKEADCPVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLV--ERTVYPEVpPRVEY 80

                         90       100
                 ....*....|....*....|..
gi 488294023  81 YLSEKGKDLATIVLQMKLWGQR 102
Cdd:COG1733   81 SLTEKGRSLLPVLDALAEWGEE 102
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 17-105 1.71e-17

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 70.79  E-value: 1.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294023   17 ILGKKWVPQIIESLNGGSMRFGEVCRLLPNSSPKMIKQQLKLLEDNEIVknEKEVFNNTTSSTYY-LSEKGKDLATIVLQ 95
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGII--NREVYPEVPPKVEYsLTEKGRSLEPILQE 78

                          90
                  ....*....|
gi 488294023   96 MKLWGQRELD 105
Cdd:pfam01638  79 LCDWGEEYLE 88
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-70 1.28e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 1.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 488294023    25 QIIESLNGGSMRFGEVCRLLpNSSPKMIKQQLKLLEDNEIVKNEKE 70
Cdd:smart00418   1 KILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVESRRE 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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