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Conserved domains on  [gi|488294115|ref|WP_002365323|]
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MULTISPECIES: GntR family transcriptional regulator [Lactobacillales]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
7-239 2.33e-73

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 223.20  E-value: 2.33e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   7 NKKAPLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTA 86
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  87 GGSFTESGLKMNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKE-DQFMLDLELTDT 165
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAAlFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488294115 166 SLLDILRQYRGVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYKVAIR 239
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
7-239 2.33e-73

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 223.20  E-value: 2.33e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   7 NKKAPLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTA 86
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  87 GGSFTESGLKMNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKE-DQFMLDLELTDT 165
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAAlFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488294115 166 SLLDILRQYRGVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYKVAIR 239
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
PRK11402 PRK11402
transcriptional regulator PhoB;
3-242 1.41e-37

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 131.50  E-value: 1.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   3 KLESNKKAPLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVE 82
Cdd:PRK11402   1 ATDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  83 SMTAGGSFTESGLKMNRKPTTKIISIClKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKE-----DQFM 157
Cdd:PRK11402  81 ALLTVSGFTDFGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSrypdfDEIY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115 158 LDleltDTSLLDILRQYRGVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYKVA 237
Cdd:PRK11402 160 VE----GSSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLT 235


                 ....*
gi 488294115 238 IRSYN 242
Cdd:PRK11402 236 IDNKR 240
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 97-235 2.83e-34

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 120.01  E-value: 2.83e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   97 MNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKEDQFMLDLE-LTDTSLLDILRQYR 175
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEdLEEGSLYDYLEERY 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  176 GVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYK 235
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 97-235 5.20e-28

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 103.91  E-value: 5.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115    97 MNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKEdqFMLDLELTD--TSLLDILRQY 174
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAA--LFPGLLEEDlsGSLYEYLEER 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488294115   175 RGVIASYFDN---IIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYK 235
Cdd:smart00866  80 LGLKIVRSTRaeqTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 13-235 5.47e-28

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 106.29  E-value: 5.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   13 YQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTAG-GSFT 91
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPISGiTSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   92 ESGLKMNRKPTTKIISI-CLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKEDQFMLDLELTDTSLLDI 170
Cdd:TIGR02404  82 ELNETLGLDSKTEVVELdKEDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488294115  171 LRQYRGVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYK 235
Cdd:TIGR02404 162 LENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFK 226
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 11-76 1.83e-27

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 99.83  E-value: 1.83e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488294115  11 PLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVS 76
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
7-239 2.33e-73

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 223.20  E-value: 2.33e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   7 NKKAPLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTA 86
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  87 GGSFTESGLKMNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKE-DQFMLDLELTDT 165
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAAlFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488294115 166 SLLDILRQYRGVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYKVAIR 239
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
PRK11402 PRK11402
transcriptional regulator PhoB;
3-242 1.41e-37

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 131.50  E-value: 1.41e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   3 KLESNKKAPLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVE 82
Cdd:PRK11402   1 ATDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  83 SMTAGGSFTESGLKMNRKPTTKIISIClKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKE-----DQFM 157
Cdd:PRK11402  81 ALLTVSGFTDFGVSQGKATKEKVIEQE-RVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSrypdfDEIY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115 158 LDleltDTSLLDILRQYRGVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYKVA 237
Cdd:PRK11402 160 VE----GSSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTLT 235


                 ....*
gi 488294115 238 IRSYN 242
Cdd:PRK11402 236 IDNKR 240
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 97-235 2.83e-34

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 120.01  E-value: 2.83e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   97 MNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKEDQFMLDLE-LTDTSLLDILRQYR 175
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEdLEEGSLYDYLEERY 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  176 GVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYK 235
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 97-235 5.20e-28

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 103.91  E-value: 5.20e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115    97 MNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKEdqFMLDLELTD--TSLLDILRQY 174
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAA--LFPGLLEEDlsGSLYEYLEER 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488294115   175 RGVIASYFDN---IIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYK 235
Cdd:smart00866  80 LGLKIVRSTRaeqTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 13-235 5.47e-28

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 106.29  E-value: 5.47e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   13 YQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTAG-GSFT 91
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPISGiTSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   92 ESGLKMNRKPTTKIISI-CLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKEDQFMLDLELTDTSLLDI 170
Cdd:TIGR02404  82 ELNETLGLDSKTEVVELdKEDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIYQY 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488294115  171 LRQYRGVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYK 235
Cdd:TIGR02404 162 LENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFK 226
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 11-76 1.83e-27

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 99.83  E-value: 1.83e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488294115  11 PLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVS 76
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 12-218 5.24e-26

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 101.40  E-value: 5.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   12 LYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTAGGSFT 91
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   92 ESGLKMNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPaIFEIDYFRKEDQF--MLDLELTDTSLLD 169
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRP-LCRATTWFPAARFpgIGQAYAASGSITD 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 488294115  170 ILRQYrGVIAsYF--DNIIEIALADEKLAEALAISEEEALVKINQTVVDND 218
Cdd:TIGR02325 168 ALREQ-GVAD-YRrsSTRISARHADAKDCARLELPPGRPLLVVQALNHDGE 216
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 11-206 8.47e-23

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 92.77  E-value: 8.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   11 PLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTAGGSF 90
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115   91 TESGLKMNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPaifeidyFRKEDQFM--------LDLEL 162
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVP-------FQLEDRLVnaaavpdyLKQDF 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 488294115  163 TDTSLLDILRQYrgVIASYFDNIIEIALADEKLAEALAISEEEA 206
Cdd:TIGR02018 154 TQTTPGAYLSQA--APLTEAEHRIEAISADPEEARLLAIDAGEP 195
PRK09764 PRK09764
GntR family transcriptional regulator;
11-235 2.12e-21

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 89.12  E-value: 2.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  11 PLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTAGGSF 90
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  91 TESGLKMNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPAIFEIDYFRKEDQFMLDLELTDTSLLDI 170
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHF 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488294115 171 LRQYRGVIASYFDNIIEIALADEKLAEALAISEEEALVKINQTVVDNDNQILYFNEQYIRSESYK 235
Cdd:PRK09764 165 IEEVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-75 5.88e-21

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 83.05  E-value: 5.88e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488294115   12 LYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFV 75
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 13-173 1.37e-20

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 87.14  E-value: 1.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  13 YQQLYDAI---LNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTAGGS 89
Cdd:PRK10079  10 YPTRYQEIaakLEQELRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQAR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  90 FTESGLKMNRKPTTKIISICLKKATGHVAEALGVEKATEVIVIERLRSLDNMPaIFEIDYFRKEDQFMLDLE-LTDTSLL 168
Cdd:PRK10079  90 FSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVA-LCLIDHYFADLTWWPTLQrFDSGSLH 168


                 ....*
gi 488294115 169 DILRQ 173
Cdd:PRK10079 169 DFLRE 173
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
8-79 2.88e-20

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 85.76  E-value: 2.88e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488294115   8 KKAPLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPS 79
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPS 75
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 3-76 3.47e-20

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 88.73  E-value: 3.47e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488294115   3 KLESNKKAPLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVS 76
Cdd:COG1167    4 RLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-76 4.99e-18

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 76.76  E-value: 4.99e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488294115   3 KLESNKKAPLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVS 76
Cdd:COG1725    2 RIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVA 75
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
16-75 6.52e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 74.92  E-value: 6.52e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115    16 LYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFV 75
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-79 2.91e-15

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 72.26  E-value: 2.91e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488294115   1 MDKLESNKKAPLYQQLYDAILNKVRSGEYQVGEKIpSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPS 79
Cdd:COG1802    1 MTSPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLS 78
PRK14999 PRK14999
histidine utilization repressor; Provisional
 10-129 4.50e-15

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 71.89  E-value: 4.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  10 APLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVSMPSYVESMTAGGS 89
Cdd:PRK14999  11 APFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 488294115  90 FTESGLKMNRKPTTKIISICLKKATGHVAEALGVEKATEV 129
Cdd:PRK14999  91 IAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVI 130
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 11-75 1.37e-10

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 59.78  E-value: 1.37e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488294115  11 PLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFV 75
Cdd:PRK10421   2 RLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 12-79 1.06e-08

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 53.87  E-value: 1.06e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488294115  12 LYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLvdENI-LIK-RHGKGTFVSMPS 79
Cdd:PRK03837  14 LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQAL--KRKgLVQiSHGERARVSRPS 81
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
14-76 6.89e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 48.86  E-value: 6.89e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488294115  14 QQLYDAILNkvrsGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVS 76
Cdd:PRK09464  17 QQLEFLILE----GTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQ 75
PRK11523 PRK11523
transcriptional regulator ExuR;
1-75 1.28e-06

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 47.92  E-value: 1.28e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 488294115   1 MDKLESNKkapLYQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFV 75
Cdd:PRK11523   1 MEITEPRR---LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 27-76 1.77e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 41.68  E-value: 1.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 488294115  27 GEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFVS 76
Cdd:PRK09990  23 GVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVA 72
PRK10225 PRK10225
Uxu operon transcriptional regulator;
13-75 8.37e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 39.62  E-value: 8.37e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488294115  13 YQQLYDAILNKVRSGEYQVGEKIPSEEQLMTIYGVSRVTVRNAIKQLVDENILIKRHGKGTFV 75
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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