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Conserved domains on  [gi|488296168|ref|WP_002367376|]
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PucR family transcriptional regulator [Enterococcus faecalis]

Protein Classification

PucR family transcriptional regulator( domain architecture ID 20581820)

PucR family transcriptional regulator similar to Bacillus subtilis purine catabolism regulatory protein PucR a transcriptional activator of the genes of purine catabolism

CATH:  1.10.10.2840
Gene Ontology:  GO:0003677|GO:0006144
PubMed:  15808743|12029039

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CdaR COG3835
Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];
282-550 6.98e-42

Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 443046 [Multi-domain]  Cd Length: 301  Bit Score: 152.49  E-value: 6.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 282 EYSRKFEEYQQRNELFFKLIAHEKRDQAVFQQFQQYYRLAIDKPYAILLISLTLNERQRQERmsilgNQLNQVILGDKQK 361
Cdd:COG3835   42 AREQLEWERRLREEFLDDLLSGNLEDEEELLERAKRLGIDLDRPRVVLVIELDSEDDESKDL-----ERLRRALRALRRD 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 362 IVCIEIDSSFVLLVEDPPEKEGDYLKMMQRlaksSINQLMKVQEDVELFLTIGPKIQGLTQIHESYQQAIDVLAFQRQFV 441
Cdd:COG3835  117 LLVALSGDRLVVLLPAESEWRDEELRELAE----RLLEELEREGGLRVRIGVGRPVPGLAGLARSYREARRALELGRRLG 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 442 AEKpemRIASYANFHLRQTLQRYFLAEGQATLRKKYLQPLLKSDQQqHTDFVHTLNVYFQSKRNLSQTAKKLFIHRNTLL 521
Cdd:COG3835  193 PEG---RVYFYDDLGLERLLLQLRDDDELAEFLEEVLGPLLEYDKH-GGELLETLRAYFENNGNISETAEALFIHRNTLR 268
                        250       260
                 ....*....|....*....|....*....
gi 488296168 522 QRLEKIEQLVLLDFDKEVDLLALEVALFV 550
Cdd:COG3835  269 YRLKKIEELTGLDLRDPEDRLLLYLALLL 297
PucR pfam07905
Purine catabolism regulatory protein-like family; The bacterial proteins found in this family ...
7-118 2.76e-37

Purine catabolism regulatory protein-like family; The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.


:

Pssm-ID: 462312 [Multi-domain]  Cd Length: 117  Bit Score: 133.74  E-value: 2.76e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168    7 DLLTLEELPGITLVAGHKNQDQPILKVNILENPDILDWLTAGELLLTTGYIFKDDRKLQKNFLKELAKHHCAALGFKTQR 86
Cdd:pfam07905   1 DLLKLPALRGARVVAGAAGLDRPVRWVHVLEVPDIARWLRGGELLLTTGYGLKDDPEALAELVRELAEAGVAGLGIKLGR 80
                          90       100       110
                  ....*....|....*....|....*....|..
gi 488296168   87 yfeEVPPDLIKLADEMNVPILAIPYNYTFSQI 118
Cdd:pfam07905  81 ---EIPEELIEAADELGLPLIELPEEVPFVEI 109
 
Name Accession Description Interval E-value
CdaR COG3835
Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];
282-550 6.98e-42

Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];


Pssm-ID: 443046 [Multi-domain]  Cd Length: 301  Bit Score: 152.49  E-value: 6.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 282 EYSRKFEEYQQRNELFFKLIAHEKRDQAVFQQFQQYYRLAIDKPYAILLISLTLNERQRQERmsilgNQLNQVILGDKQK 361
Cdd:COG3835   42 AREQLEWERRLREEFLDDLLSGNLEDEEELLERAKRLGIDLDRPRVVLVIELDSEDDESKDL-----ERLRRALRALRRD 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 362 IVCIEIDSSFVLLVEDPPEKEGDYLKMMQRlaksSINQLMKVQEDVELFLTIGPKIQGLTQIHESYQQAIDVLAFQRQFV 441
Cdd:COG3835  117 LLVALSGDRLVVLLPAESEWRDEELRELAE----RLLEELEREGGLRVRIGVGRPVPGLAGLARSYREARRALELGRRLG 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 442 AEKpemRIASYANFHLRQTLQRYFLAEGQATLRKKYLQPLLKSDQQqHTDFVHTLNVYFQSKRNLSQTAKKLFIHRNTLL 521
Cdd:COG3835  193 PEG---RVYFYDDLGLERLLLQLRDDDELAEFLEEVLGPLLEYDKH-GGELLETLRAYFENNGNISETAEALFIHRNTLR 268
                        250       260
                 ....*....|....*....|....*....
gi 488296168 522 QRLEKIEQLVLLDFDKEVDLLALEVALFV 550
Cdd:COG3835  269 YRLKKIEELTGLDLRDPEDRLLLYLALLL 297
PucR pfam07905
Purine catabolism regulatory protein-like family; The bacterial proteins found in this family ...
7-118 2.76e-37

Purine catabolism regulatory protein-like family; The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.


Pssm-ID: 462312 [Multi-domain]  Cd Length: 117  Bit Score: 133.74  E-value: 2.76e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168    7 DLLTLEELPGITLVAGHKNQDQPILKVNILENPDILDWLTAGELLLTTGYIFKDDRKLQKNFLKELAKHHCAALGFKTQR 86
Cdd:pfam07905   1 DLLKLPALRGARVVAGAAGLDRPVRWVHVLEVPDIARWLRGGELLLTTGYGLKDDPEALAELVRELAEAGVAGLGIKLGR 80
                          90       100       110
                  ....*....|....*....|....*....|..
gi 488296168   87 yfeEVPPDLIKLADEMNVPILAIPYNYTFSQI 118
Cdd:pfam07905  81 ---EIPEELIEAADELGLPLIELPEEVPFVEI 109
HTH_30 pfam13556
PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the ...
495-548 1.45e-15

PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Swiss:O32138 and is likely to be DNA-binding.


Pssm-ID: 433305 [Multi-domain]  Cd Length: 56  Bit Score: 70.95  E-value: 1.45e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488296168  495 TLNVYFQSKRNLSQTAKKLFIHRNTLLQRLEKIEQLVLLDFDKEVDLLALEVAL 548
Cdd:pfam13556   1 TLRAYLENGGNISATARALHVHRNTLRYRLRRIEELLGLDLDDPEDRLALYLAL 54
PRK11477 PRK11477
CdaR family transcriptional regulator;
394-548 1.07e-05

CdaR family transcriptional regulator;


Pssm-ID: 183155 [Multi-domain]  Cd Length: 385  Bit Score: 47.83  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 394 KSSINQLM-KVQEDVELFLTI--GPKIQGLTQIHESYQQAIDVLAFQRQFVaekPEMRIASYANFHLRQTLQRyfLAEG- 469
Cdd:PRK11477 228 RKRVEQLIsRMKEYGQLRFRValGNYFTGPGSIARSYRTAKTTMVVGKQRM---PESRCYFYQDLMLPVLLDS--LRGGw 302
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488296168 470 QATLRKKYLQPLLKSDQQQHtdFVHTLNVYFQSKRNLSQTAKKLFIHRNTLLQRLEKIEQLVLLDFDKEVDLLALEVAL 548
Cdd:PRK11477 303 QANELARPLARLKAMDNNGL--LRRTLAAWFRHNVQPLATSKALFIHRNTLEYRLNRISELTGLDLGNFDDRLLLYVAL 379
 
Name Accession Description Interval E-value
CdaR COG3835
Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];
282-550 6.98e-42

Sugar diacid utilization regulator CdaR [Transcription, Signal transduction mechanisms];


Pssm-ID: 443046 [Multi-domain]  Cd Length: 301  Bit Score: 152.49  E-value: 6.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 282 EYSRKFEEYQQRNELFFKLIAHEKRDQAVFQQFQQYYRLAIDKPYAILLISLTLNERQRQERmsilgNQLNQVILGDKQK 361
Cdd:COG3835   42 AREQLEWERRLREEFLDDLLSGNLEDEEELLERAKRLGIDLDRPRVVLVIELDSEDDESKDL-----ERLRRALRALRRD 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 362 IVCIEIDSSFVLLVEDPPEKEGDYLKMMQRlaksSINQLMKVQEDVELFLTIGPKIQGLTQIHESYQQAIDVLAFQRQFV 441
Cdd:COG3835  117 LLVALSGDRLVVLLPAESEWRDEELRELAE----RLLEELEREGGLRVRIGVGRPVPGLAGLARSYREARRALELGRRLG 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 442 AEKpemRIASYANFHLRQTLQRYFLAEGQATLRKKYLQPLLKSDQQqHTDFVHTLNVYFQSKRNLSQTAKKLFIHRNTLL 521
Cdd:COG3835  193 PEG---RVYFYDDLGLERLLLQLRDDDELAEFLEEVLGPLLEYDKH-GGELLETLRAYFENNGNISETAEALFIHRNTLR 268
                        250       260
                 ....*....|....*....|....*....
gi 488296168 522 QRLEKIEQLVLLDFDKEVDLLALEVALFV 550
Cdd:COG3835  269 YRLKKIEELTGLDLRDPEDRLLLYLALLL 297
PucR pfam07905
Purine catabolism regulatory protein-like family; The bacterial proteins found in this family ...
7-118 2.76e-37

Purine catabolism regulatory protein-like family; The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being putative regulatory proteins.


Pssm-ID: 462312 [Multi-domain]  Cd Length: 117  Bit Score: 133.74  E-value: 2.76e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168    7 DLLTLEELPGITLVAGHKNQDQPILKVNILENPDILDWLTAGELLLTTGYIFKDDRKLQKNFLKELAKHHCAALGFKTQR 86
Cdd:pfam07905   1 DLLKLPALRGARVVAGAAGLDRPVRWVHVLEVPDIARWLRGGELLLTTGYGLKDDPEALAELVRELAEAGVAGLGIKLGR 80
                          90       100       110
                  ....*....|....*....|....*....|..
gi 488296168   87 yfeEVPPDLIKLADEMNVPILAIPYNYTFSQI 118
Cdd:pfam07905  81 ---EIPEELIEAADELGLPLIELPEEVPFVEI 109
PucR COG2508
DNA-binding transcriptional regulator, PucR/PutR family [Transcription];
426-548 1.32e-23

DNA-binding transcriptional regulator, PucR/PutR family [Transcription];


Pssm-ID: 441998 [Multi-domain]  Cd Length: 257  Bit Score: 100.07  E-value: 1.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 426 SYQQAIDVLAFQRQFVAEKpemRIASYANFHLRQTLQRYFLAEGQATLRKKYLQPLLKSDQQQHTDFVHTLNVYFQSKRN 505
Cdd:COG2508  128 SYREARRALRLARALPGGG---RVVRYDDLGLYRLLLALADPEALRAFVERVLGPLLEYDAEHGTDLLETLRAYLDNGGN 204
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 488296168 506 LSQTAKKLFIHRNTLLQRLEKIEQLVLLDFDKEVDLLALEVAL 548
Cdd:COG2508  205 VSATARALHVHRNTVRYRLRRIEELLGRDLDDPEDRLELQLAL 247
HTH_30 pfam13556
PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the ...
495-548 1.45e-15

PucR C-terminal helix-turn-helix domain; This helix-turn-helix domain is often found at the C-terminus of PucR-like transcriptional regulators such as Swiss:O32138 and is likely to be DNA-binding.


Pssm-ID: 433305 [Multi-domain]  Cd Length: 56  Bit Score: 70.95  E-value: 1.45e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 488296168  495 TLNVYFQSKRNLSQTAKKLFIHRNTLLQRLEKIEQLVLLDFDKEVDLLALEVAL 548
Cdd:pfam13556   1 TLRAYLENGGNISATARALHVHRNTLRYRLRRIEELLGLDLDDPEDRLALYLAL 54
PRK11477 PRK11477
CdaR family transcriptional regulator;
394-548 1.07e-05

CdaR family transcriptional regulator;


Pssm-ID: 183155 [Multi-domain]  Cd Length: 385  Bit Score: 47.83  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168 394 KSSINQLM-KVQEDVELFLTI--GPKIQGLTQIHESYQQAIDVLAFQRQFVaekPEMRIASYANFHLRQTLQRyfLAEG- 469
Cdd:PRK11477 228 RKRVEQLIsRMKEYGQLRFRValGNYFTGPGSIARSYRTAKTTMVVGKQRM---PESRCYFYQDLMLPVLLDS--LRGGw 302
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 488296168 470 QATLRKKYLQPLLKSDQQQHtdFVHTLNVYFQSKRNLSQTAKKLFIHRNTLLQRLEKIEQLVLLDFDKEVDLLALEVAL 548
Cdd:PRK11477 303 QANELARPLARLKAMDNNGL--LRRTLAAWFRHNVQPLATSKALFIHRNTLEYRLNRISELTGLDLGNFDDRLLLYVAL 379
GGDEF_2 pfam17853
GGDEF-like domain; This domain is distantly related to the GGDEF domain, suggesting these may ...
316-435 3.05e-05

GGDEF-like domain; This domain is distantly related to the GGDEF domain, suggesting these may by diguanylate cyclase enzymes.


Pssm-ID: 465533  Cd Length: 116  Bit Score: 43.47  E-value: 3.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168  316 QYYRLAIDKPYAILLISLtlnERQRQERMSILGNQLNQVilgdKQKIVCIEIDSSFVLLVEDPPEKEGDYLkmmqrlaks 395
Cdd:pfam17853  13 RRLGLDLDGPHVVVVVEL---DEDADRLLRALERALRAL----GRGALVAVRGDRLVLLLPADDEADAEAL--------- 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 488296168  396 sINQLMKVQEDVELFLTIGPKIQGLTQIHESYQQAIDVLA 435
Cdd:pfam17853  77 -LERLARALGGLPVRVGVGRPAAGLAGLRRSYREARRALR 115
DRTGG pfam07085
DRTGG domain; This presumed domain is about 120 amino acids in length. It is found associated ...
18-116 1.78e-04

DRTGG domain; This presumed domain is about 120 amino acids in length. It is found associated with CBS domains pfam00571, as well as the CbiA domain pfam01656. The function of this domain is unknown. It is named the DRTGG domain after some of the most conserved residues. This domain may be very distantly related to a pair of CBS domains. There are no significant sequence similarities, but its length and association with CBS domains supports this idea (Bateman A, pers. obs.).


Pssm-ID: 429285 [Multi-domain]  Cd Length: 105  Bit Score: 40.94  E-value: 1.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488296168   18 TLVAGHKNQDQPILKVNI----LENpdILDWLTAGELLLTTGyifkdDRKlqkNFLKELAKHHCAAL----GFktqryfe 89
Cdd:pfam07085   9 EVLNGGDGLLRRVGKVVVgamsVEN--MLKYLRPGDLVITPG-----DRE---DIQLAALEAGIAGLiltgGF------- 71
                          90       100
                  ....*....|....*....|....*..
gi 488296168   90 EVPPDLIKLADEMNVPILAIPYNyTFS 116
Cdd:pfam07085  72 EPSPEVLKLAEELGLPVLSTPYD-TFT 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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