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Conserved domains on  [gi|488302628|ref|WP_002373750|]
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MULTISPECIES: diacylglycerol kinase family protein [Enterococcus]

Protein Classification

diacylglycerol/lipid kinase family protein( domain architecture ID 11446635)

diacylglycerol/lipid kinase family protein may catalyze the ATP-dependent phosphorylation of diacylglycerol and/or other lipids, and is involved in the phospholipid biosynthetic process

CATH:  3.40.50.10330
EC:  2.7.1.-
Gene Ontology:  GO:0008654|GO:0001727|GO:0005524|GO:0016310
SCOP:  3001940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-294 1.23e-96

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


:

Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 286.36  E-value: 1.23e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEq 80
Cdd:COG1597    2 MMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  81 eHRPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDAEKKTKFGKLA 160
Cdd:COG1597   81 -TGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 161 YFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLLK 240
Cdd:COG1597  160 YVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLR 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488302628 241 GVDGSTKNLAYLTCEQLVVSLadEEELTTNVDGDE-GDKLPVNIKVLPSHLQVYC 294
Cdd:COG1597  240 GRHLRHPGVRYFRAREVEIES--DRPLPVQLDGEPlGLATPLEFEVLPGALRVLV 292
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-294 1.23e-96

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 286.36  E-value: 1.23e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEq 80
Cdd:COG1597    2 MMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  81 eHRPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDAEKKTKFGKLA 160
Cdd:COG1597   81 -TGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 161 YFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLLK 240
Cdd:COG1597  160 YVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLR 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488302628 241 GVDGSTKNLAYLTCEQLVVSLadEEELTTNVDGDE-GDKLPVNIKVLPSHLQVYC 294
Cdd:COG1597  240 GRHLRHPGVRYFRAREVEIES--DRPLPVQLDGEPlGLATPLEFEVLPGALRVLV 292
PRK13337 PRK13337
putative lipid kinase; Reviewed
 1-294 1.21e-71

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 223.00  E-value: 1.21e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQ 80
Cdd:PRK13337   1 MKRARIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  81 EHRPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDAEKKTKFGKLA 160
Cdd:PRK13337  81 ENRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 161 YFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLLK 240
Cdd:PRK13337 161 YYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIHIATLALR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488302628 241 GVDGSTKNLAYLTCEQLVVSLADEEELttNVDGDEGDKLPVNIKVLPSHLQVYC 294
Cdd:PRK13337 241 GEHIKHPKVIYTKANRIKVSSFDKMQL--NLDGEYGGKLPAEFENLYRHIEVFV 292
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 1-292 1.52e-58

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 189.25  E-value: 1.52e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628    1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQ 80
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   81 EHRPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDY-FMNVVAIGSIPEAINDVDAEKKTKFGKL 159
Cdd:TIGR00147  81 DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEKLKAALGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  160 AYFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLL 239
Cdd:TIGR00147 161 SYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSD 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488302628  240 KGVDGSTKNLAYLTCEQlvVSLADEEELTTNVDGDEGDKLPVNIKVLPSHLQV 292
Cdd:TIGR00147 241 EGKHTDNPNIIYGKASR--IDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRC 291
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 3-127 5.82e-43

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 143.49  E-value: 5.82e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628    3 KVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQEH 82
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 488302628   83 RPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKI 127
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 5-108 1.13e-13

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 66.55  E-value: 1.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628     5 LLVVNPSSGGEQAKEFeqlaIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQE--- 81
Cdd:smart00046   1 LVFVNPKSGGGKGEKL----LRKFRLLLNPRQVFDLTKKGPAVALVIFRDVPDFNRVLVCGGDGTVGWVLNALDKRElpl 76

                           90       100
                   ....*....|....*....|....*..
gi 488302628    82 HRPNFGFFPLGTVNDLARALGIPLEPE 108
Cdd:smart00046  77 PEPPVAVLPLGTGNDLARSLGWGGGYD 103
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 1-294 1.23e-96

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 286.36  E-value: 1.23e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEq 80
Cdd:COG1597    2 MMRALLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  81 eHRPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDAEKKTKFGKLA 160
Cdd:COG1597   81 -TGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVNGRYFLNVAGIGFDAEVVERANRALKRRLGKLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 161 YFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLLK 240
Cdd:COG1597  160 YVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLRLLPRLLR 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488302628 241 GVDGSTKNLAYLTCEQLVVSLadEEELTTNVDGDE-GDKLPVNIKVLPSHLQVYC 294
Cdd:COG1597  240 GRHLRHPGVRYFRAREVEIES--DRPLPVQLDGEPlGLATPLEFEVLPGALRVLV 292
PRK13337 PRK13337
putative lipid kinase; Reviewed
 1-294 1.21e-71

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 223.00  E-value: 1.21e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQ 80
Cdd:PRK13337   1 MKRARIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  81 EHRPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDAEKKTKFGKLA 160
Cdd:PRK13337  81 ENRPKLGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKANNRYFINIAGGGRLTELTYEVPSKLKTMLGQLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 161 YFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLLK 240
Cdd:PRK13337 161 YYLKGIEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELIHIATLALR 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 488302628 241 GVDGSTKNLAYLTCEQLVVSLADEEELttNVDGDEGDKLPVNIKVLPSHLQVYC 294
Cdd:PRK13337 241 GEHIKHPKVIYTKANRIKVSSFDKMQL--NLDGEYGGKLPAEFENLYRHIEVFV 292
PRK13055 PRK13055
putative lipid kinase; Reviewed
 1-293 2.45e-64

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 205.22  E-value: 2.45e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGD-AKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAE 79
Cdd:PRK13055   2 QKRARLIYNPTSGQEIMKKNVADILDILEQAGYETSAFQTTPEPNsAKNEAKRAAEAGFDLIIAAGGDGTINEVVNGIAP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  80 QEHRPNFGFFPLGTVNDLARALGIPL-EPEEAIKHFSIESVKPLDIGKINDD-YFMNVVAIGSIPEAINDVDAEKKTKFG 157
Cdd:PRK13055  82 LEKRPKMAIIPAGTTNDYARALKIPRdNPVEAAKVILKNQTIKMDIGRANEDkYFINIAAGGSLTELTYSVPSQLKSMFG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 158 KLAYFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPD 237
Cdd:PRK13055 162 YLAYLAKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVPDAKLDDGKFTLIIVKTANLFELLHLMAL 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488302628 238 LLKG---VDgsTKNLAYLTCEQLVVSLADEEELTTNVDGDEGDKLPVNIKVLPSHLQVY 293
Cdd:PRK13055 242 ILNGgkhID--DPRVIYIKTSKLTIEPLGDDRLMVNLDGEYGGDAPMTFENLKQHIEFF 298
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 1-292 1.52e-58

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 189.25  E-value: 1.52e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628    1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQ 80
Cdd:TIGR00147   1 MAEAPAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   81 EHRPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDY-FMNVVAIGSIPEAINDVDAEKKTKFGKL 159
Cdd:TIGR00147  81 DDIPALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVNKQYcFINMAGGGFGTEITTETPEKLKAALGSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  160 AYFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLL 239
Cdd:TIGR00147 161 SYILSGLMRMDTLQPFRCEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLLPALVLTLMSD 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 488302628  240 KGVDGSTKNLAYLTCEQlvVSLADEEELTTNVDGDEGDKLPVNIKVLPSHLQV 292
Cdd:TIGR00147 241 EGKHTDNPNIIYGKASR--IDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRC 291
PRK13054 PRK13054
lipid kinase; Reviewed
 1-293 7.81e-44

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 151.18  E-value: 7.81e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNpssgGEQAKEfEQL--AIEKLEsvfDEVVVLH---TKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGIS 75
Cdd:PRK13054   3 FPKSLLILN----GKSAGN-EELreAVGLLR---EEGHTLHvrvTWEKGDAARYVEEALALGVATVIAGGGDGTINEVAT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  76 GIA--EQEHRPNFGFFPLGTVNDLARALGIPLEPEEAIKhFSIE-SVKPLDIGKINDD-YFMNVVAIGSIPEAINDVDAE 151
Cdd:PRK13054  75 ALAqlEGDARPALGILPLGTANDFATAAGIPLEPDKALK-LAIEgRAQPIDLARVNDRtYFINMATGGFGTRVTTETPEK 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 152 KKTKFGKLAYFMSGIKQLASTQSYSfhVEVDGKKEEIESSTLLIGLTNS--VGGFETLLPNAKVDDGKLHLVYLKdsSLI 229
Cdd:PRK13054 154 LKAALGGVAYLIHGLMRMDTLKPDR--CEIRGPDFHWQGDALVIGIGNGrqAGGGQQLCPEALINDGLLDLRILP--APQ 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 488302628 230 DTLKTLPDLLKGVDGSTKNLAYLTCEQLVVSLAdeEELTTNVDGD--EGDKLpvNIKVLPSHLQVY 293
Cdd:PRK13054 230 ELLPTLLSTLTGGSEDNPNIIRARLPWLEIQAP--HELTFNLDGEplSGRHF--RIEVLPAALRCR 291
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 3-127 5.82e-43

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 143.49  E-value: 5.82e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628    3 KVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQEH 82
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLAT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 488302628   83 RPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKI 127
Cdd:pfam00781  81 RPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
PRK13057 PRK13057
lipid kinase;
5-293 3.92e-37

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 133.50  E-value: 3.92e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   5 LLVVNPSSggEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAvEGYHSVFVMGGDGTVNEGISGIAEQehRP 84
Cdd:PRK13057   1 LLLVNRHA--RSGRAALAAARAALEAAGLELVEPPAEDPDDLSEVIEAYA-DGVDLVIVGGGDGTLNAAAPALVET--GL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  85 NFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDAEKKTKFGKLAYFMS 164
Cdd:PRK13057  76 PLGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWVNGHYFFNVASLGLSAELARRLTKELKRRWGTLGYAIA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 165 GIKQLASTQSYSFHVEVDGKKEEIEssTLLIGLTNSV--GGFETLLPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLLKGV 242
Cdd:PRK13057 156 ALRVLRRSRPFTAEIEHDGRTERVK--TLQVAVGNGRyyGGGMTVAHDATIDDGRLDLYSLEVAHWWRLLALLPALRRGR 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 488302628 243 DGSTKNLAYLTCEQLVVSLADEEELttNVDGDEGDKLPVNIKVLPSHLQVY 293
Cdd:PRK13057 234 HGEWPDVRAFRTTELELRTRKPRPI--NTDGELTTYTPAHFRVLPKALRVL 282
PRK13059 PRK13059
putative lipid kinase; Reviewed
 1-292 1.33e-36

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 132.08  E-value: 1.33e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSGgeqakefEQLAIEKLesvfDEVVVLHTKKAGDA------KNFTREAAV----EGYHSVFVMGGDGTV 70
Cdd:PRK13059   1 MKKVKFIYNPYSG-------ENAIISEL----DKVIRIHQEKGYLVvpyrisLEYDLKNAFkdidESYKYILIAGGDGTV 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  71 NEGISGIAEQEHRPNFGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDA 150
Cdd:PRK13059  70 DNVVNAMKKLNIDLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKINDKYFINVASTGLFTDVSQKTDV 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 151 EKKTKFGKLAYFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLLIGLTNSVGGFEtLLPNAKVDDGKLHLVYLKDSSLID 230
Cdd:PRK13059 150 NLKNTIGKLAYYLKGLEELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTAGNFN-LAYKAEVDDGLLDVIIIKACPIID 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 488302628 231 TLKTLPDLLKG--VDgSTKNLAYLTCEQLVVSlaDEEELTTNVDGDEGDKLPVNIKVLPSHLQV 292
Cdd:PRK13059 229 LIPLFIKVLKGehLE-DVNGLIYFKTDKLEIE--SNEEIVTDIDGERGPDFPLNIECIKGGLKV 289
PRK12361 PRK12361
hypothetical protein; Provisional
 2-294 3.57e-26

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 107.78  E-value: 3.57e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   2 KKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDeVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQE 81
Cdd:PRK12361 243 KRAWLIANPVSGGGKWQEYGEQIQRELKAYFD-LTVKLTTPEISAEALAKQARKAGADIVIACGGDGTVTEVASELVNTD 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  82 HRpnFGFFPLGTVNDLARAL---GIPLEP-EEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDAEKKTKFG 157
Cdd:PRK12361 322 IT--LGIIPLGTANALSHALfglGSKLIPvEQACDNIIQGHTQRIDTARCNDRLMLLLVGIGFEQKMIESADRERKNALG 399

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 158 KLAYFMSGIKQLASTQSYSFHVEVDGKK-EEIESSTLLIGltnSVGGFETLL------PNakVDDGKLHLVYL-KDSSLI 229
Cdd:PRK12361 400 QLAYLDGLWRAVNENETLTLTVTLDDAEpQTISTHSLVVA---NAAPFTSLLaqgggePN--MTDGLLDITWLdSGGEPG 474

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 230 DTLKTLPDL-LKGVDGS--TKNLAYLTCEqlVVSLADEEELTTNVDGD--EGDKLpvNIKVLPSHLQVYC 294
Cdd:PRK12361 475 EQLLSLAELaLSGLGKEpeANKVHHAHAK--KVTISSQKPIKYVIDGElfEDEDL--TIEVQPASLKVFV 540
PRK00861 PRK00861
putative lipid kinase; Reviewed
 1-293 1.35e-25

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 103.16  E-value: 1.35e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSG-GEQAKEFEQLAiEKLESVFDEVVVLHTKKAGdAKNFTREAAVEGYHSVFVMGGDGTvnegISGIAE 79
Cdd:PRK00861   2 TRSACLIFNPVAGqGNPEVDLALIR-AILEPEMDLDIYLTTPEIG-ADQLAQEAIERGAELIIASGGDGT----LSAVAG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  80 QEHRPN--FGFFPLGTVNDLARALGIPLEPEEAIKHFSIESVKPLDIGKINDDYFMNVVAIGSIPEAINDVDAEKKTKFG 157
Cdd:PRK00861  76 ALIGTDipLGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVDVAYCNGQPMILLAGIGFEAETVEEADREAKNRFG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 158 KLAYFMSGIKQLASTQSYSFHVEVDGKKeeIESSTLLIGLTN-----SV--GGFETLLPnakvDDGKLHLVYLKDSSLID 230
Cdd:PRK00861 156 ILAYILSGLQQLRELESFEVEIETEDQI--ITTNAVAVTVANaapptSVlaQGPGAVIP----DDGLLDVTIVAPKNLAE 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488302628 231 TLKTLPDLL-KGVDGST---KNLAYLTCEQLVVSLADEEELTtnVDGDEGDKLPVNIKVLPSHLQVY 293
Cdd:PRK00861 230 AVAASYHLLqTALQGNPaerDDIGYLRAKQVKITTDPPQKVV--IDGEVVGTTPIEIECLPRSLKVF 294
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 1-292 1.38e-22

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 94.85  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   1 MKKVLLVVNPSSGGEQAKEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQ 80
Cdd:PRK11914   8 IGKVTVLTNPLSGHGAAPHAAERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVISNALQVLAGT 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  81 EhRPnFGFFPLGTVNDLARALGIPL-EPEEAIKHFSIESVKPLDIGKINDD-----YFMNVVAIGsIPEAINDVDAEKKT 154
Cdd:PRK11914  88 D-IP-LGIIPAGTGNDHAREFGIPTgDPEAAADVIVDGWTETVDLGRIQDDdgivkWFGTVAATG-FDSLVTDRANRMRW 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 155 KFGKLAYFMSGIKQLASTQSYSFHVEVDGKKEEIESSTLL-IGLTNSVGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLK 233
Cdd:PRK11914 165 PHGRMRYNLAMLAELSKLRPLPFRLVLDGTEEIVTDLTLAaFGNTRSYGGGMLICPNADHTDGLLDITMVQSASRTRLLR 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 488302628 234 TLPDLLKGvdgSTKNLAYLTCEQLVVSLADEEELTTNVDGDEGDKLPVNIKVLPSHLQV 292
Cdd:PRK11914 245 LFPTVFKG---THVELDEVSTARAKTVHVECPGINAYADGDFACPLPAEISAVPGALQI 300
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 5-108 1.13e-13

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 66.55  E-value: 1.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628     5 LLVVNPSSGGEQAKEFeqlaIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQE--- 81
Cdd:smart00046   1 LVFVNPKSGGGKGEKL----LRKFRLLLNPRQVFDLTKKGPAVALVIFRDVPDFNRVLVCGGDGTVGWVLNALDKRElpl 76

                           90       100
                   ....*....|....*....|....*..
gi 488302628    82 HRPNFGFFPLGTVNDLARALGIPLEPE 108
Cdd:smart00046  77 PEPPVAVLPLGTGNDLARSLGWGGGYD 103
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 156-294 2.14e-10

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 57.98  E-value: 2.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  156 FGKLAYFMSGIKQLASTQSYSFHVEVDGkkEEIESSTLLIGLTNS--VGGFETLLPNAKVDDGKLHLVYLKDSSLIDTLK 233
Cdd:pfam19279  22 PGALSYPAAALRALATFRPLRYRVTVDG--EVREFSAALVAVANSgyYGGGMRIAPDARVDDGLLDVVVIEAASRRTLLR 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 488302628  234 TLPDLLkgvDGSTKNLAYLTCEQL-VVSLADEEELTTNVDGDEGDKLPVNIKVLPSHLQVYC 294
Cdd:pfam19279 100 LLPKVY---DGRHVRLPQVEVLRGrEVRIEADRPLPAGADGEVLGPLPVRVEVLPGALRVLA 158
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
 2-259 7.99e-06

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 46.78  E-value: 7.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628   2 KKVLLVVNPSSGGEQA-KEFEQLAIEKLESVFDEVVVLHTKKAGDAKNFTREAAVEGYHSVFVMGGDGTVNEGISGIAEQ 80
Cdd:PLN02958 112 KRLLVFVNPFGGKKSAsKIFFDVVKPLLEDADIQLTIQETKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNGLLER 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628  81 EH-----RPNFGFFPLGTVNDLARAL----GIPLEPEEAIKHFSIESVKPLDIGKI--NDDYFMNVVAIGSIPEAINDVD 149
Cdd:PLN02958 192 EDwktaiKLPIGMVPAGTGNGMAKSLldsvGEPCSATNAVLAIIRGHKCSLDVATIlqGETKFFSVLMLAWGLVADIDIE 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488302628 150 AEKKTKFGKLAYFMSGIKQLASTQSY-------------------SFHVEVDGKKEEIESSTLL-----IGLTN------ 199
Cdd:PLN02958 272 SEKYRWMGSARLDFYGLQRILCLRQYngrisfvpapgfeaygeptSYNGESTSKEESGKDKQHGyqgpdVKLENldwrti 351

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 488302628 200 -----SV-------GGFETL-LPNAKVDDGKLHLVYLKDSSLIDTLKTLPDLLKGVDGSTKNLAYLTCEQLVV 259
Cdd:PLN02958 352 kgpfvSVwlhnvpwGGEDTLaAPDAKFSDGYLDLILIKDCPKLALLALMTKLSDGTHVKSPYVMYLKVKAFVL 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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