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Conserved domains on  [gi|488305844|ref|WP_002376293|]
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MULTISPECIES: adenylosuccinate synthase [Enterococcus]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10011626)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  3.40.440.10|3.90.170.10|1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0044208|GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  8244965|11916378|6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-428 0e+00

adenylosuccinate synthetase; Provisional


:

Pssm-ID: 234904  Cd Length: 430  Bit Score: 846.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   1 MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLV 80
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  81 KELAYLKENNVAT-DNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAER 159
Cdd:PRK01117  81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 160 LKINLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTS 239
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 240 SNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKR 319
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 320 VSGITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHR 399
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                        410       420
                 ....*....|....*....|....*....
gi 488305844 400 ISELVGVRISTFSVGPDRNQTNVLESVWA 428
Cdd:PRK01117 401 IEELTGVPISIISTGPDRDQTIILRDPFA 429
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-428 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 846.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   1 MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLV 80
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  81 KELAYLKENNVAT-DNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAER 159
Cdd:PRK01117  81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 160 LKINLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTS 239
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 240 SNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKR 319
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 320 VSGITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHR 399
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                        410       420
                 ....*....|....*....|....*....
gi 488305844 400 ISELVGVRISTFSVGPDRNQTNVLESVWA 428
Cdd:PRK01117 401 IEELTGVPISIISTGPDRDQTIILRDPFA 429
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 3-424 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 810.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   3 SVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKE 82
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  83 LAYLKENNV-ATDNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLK 161
Cdd:COG0104   81 IDGLEARGVdVRSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 162 INLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSN 241
Cdd:COG0104  161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 242 PVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVS 321
Cdd:COG0104  241 TTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 322 GITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRIS 401
Cdd:COG0104  321 GLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIE 400

                        410       420
                 ....*....|....*....|...
gi 488305844 402 ELVGVRISTFSVGPDRNQTNVLE 424
Cdd:COG0104  401 ELLGVPISIVSVGPDREQTIVRR 423
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
5-420 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 774.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844    5 VVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKELA 84
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   85 YLKENNV-ATDNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLKIN 163
Cdd:pfam00709  81 ELEERGIdVPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  164 LEEKNRQFVKMFDsEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPV 243
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  244 AGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVSGI 323
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  324 TNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRISEL 403
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEEL 399

                         410
                  ....*....|....*..
gi 488305844  404 VGVRISTFSVGPDRNQT 420
Cdd:pfam00709 400 LGVPIKIISVGPDREQT 416
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 3-420 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 733.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844     3 SVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKE 82
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844    83 LAYLKENNVA-TDNLRISDRAHVILPYHIKLDQLQEDAKgenkIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLK 161
Cdd:smart00788  81 IEELEAKGVDvKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   162 INLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSN 241
Cdd:smart00788 157 ELLDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   242 PVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVS 321
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   322 GITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRIS 401
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIE 396

                          410
                   ....*....|....*....
gi 488305844   402 ELVGVRISTFSVGPDRNQT 420
Cdd:smart00788 397 ELVGVPVSIISTGPDREQT 415
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 5-426 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 623.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844    5 VVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKELA 84
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   85 YLKENNVAT-DNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLKIN 163
Cdd:TIGR00184  81 YLEKRGISVrDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  164 LEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPV 243
Cdd:TIGR00184 161 LEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  244 AGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVSGI 323
Cdd:TIGR00184 241 AGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  324 TNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRISEL 403
Cdd:TIGR00184 321 TQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEEL 400

                         410       420
                  ....*....|....*....|...
gi 488305844  404 VGVRISTFSVGPDRNQTNVLESV 426
Cdd:TIGR00184 401 TGVPVTIISTGPEREQTIDLRKE 423
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 2-420 1.19e-180

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 505.88  E-value: 1.19e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   2 SSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVK 81
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  82 ELAYLKENNVA-TDNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADlldkeifaerl 160
Cdd:cd03108   81 EIEELEKKGIDvKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD----------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 161 kinleeknrqfvkmfdseaiefddifeeyyeygqqikQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSS 240
Cdd:cd03108  150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 241 NPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRV 320
Cdd:cd03108  193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 321 SGITNLSLNSIDVlsgletvkictayeldgeliyhypaslkelsrckpvyeelpgwseditgcktladlpaNARNYVHRI 400
Cdd:cd03108  273 NGLTELALTKLDV----------------------------------------------------------NAQKYIERI 294

                        410       420
                 ....*....|....*....|
gi 488305844 401 SELVGVRISTFSVGPDRNQT 420
Cdd:cd03108  295 EELLGVPITYISVGPDREQT 314
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
5-322 3.02e-34

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 129.41  E-value: 3.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   5 VVVGTQWGDEGKGKITDFLSENAEVIARYQ-GGDNAGHT-IKFDGVTYKLHLIPSGIFY-KEKISVIGNGVVVNPKSLVK 81
Cdd:NF038379   3 VVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTyIDDEGRKFVHRMLPNGIVSpPLKQVLIGPGSEIDLEVLRE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  82 ELAYLKEN-NVATDNLRISDRAHVILPYHikldQLQEDAKGENKIGTTIKGIGPAYMDK----AARVGIRIADLLDKEIf 156
Cdd:NF038379  83 EIEELEDAgHDVGKRLLIHEQATVIELHK----HVEEEAGPMTKIGSTKKGIGAARAAKirrnPSTLGDAEGDFGEGAV- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 157 aerlkinleeknrqfvkmfDSEAIEFDDIFEEYYEYGQqikqyvtdtsvilndALDAGKRVLFEGAQGVMLDIDQGTYPF 236
Cdd:NF038379 158 -------------------RDQPWEIAERVVDNALYDF---------------ALQAAERIQIEGTQGYSLGLHAGFYPY 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 237 VTSSNPVAGGVTIGSGVGPS--KINKVVGVCKAYTSRVGD-----GPFPTEL-FDETGetirrVGKEYGTTTGRPRRVGW 308
Cdd:NF038379 204 CTSRDCTPADFLADAGIPLPnvDAFKVVGTARTYPIRVAGwsgnsYPDQGETtWEELG-----LPEELTTVTKKVRRVGT 278

                        330
                 ....*....|....
gi 488305844 309 FDSVVMRHSKRVSG 322
Cdd:NF038379 279 FSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-428 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 846.25  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   1 MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLV 80
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  81 KELAYLKENNVAT-DNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAER 159
Cdd:PRK01117  81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 160 LKINLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTS 239
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 240 SNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKR 319
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 320 VSGITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHR 399
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                        410       420
                 ....*....|....*....|....*....
gi 488305844 400 ISELVGVRISTFSVGPDRNQTNVLESVWA 428
Cdd:PRK01117 401 IEELTGVPISIISTGPDRDQTIILRDPFA 429
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 3-424 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 810.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   3 SVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKE 82
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  83 LAYLKENNV-ATDNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLK 161
Cdd:COG0104   81 IDGLEARGVdVRSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 162 INLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSN 241
Cdd:COG0104  161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 242 PVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVS 321
Cdd:COG0104  241 TTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 322 GITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRIS 401
Cdd:COG0104  321 GLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIE 400

                        410       420
                 ....*....|....*....|...
gi 488305844 402 ELVGVRISTFSVGPDRNQTNVLE 424
Cdd:COG0104  401 ELLGVPISIVSVGPDREQTIVRR 423
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
5-420 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 774.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844    5 VVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKELA 84
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   85 YLKENNV-ATDNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLKIN 163
Cdd:pfam00709  81 ELEERGIdVPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  164 LEEKNRQFVKMFDsEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPV 243
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  244 AGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVSGI 323
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  324 TNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRISEL 403
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEEL 399

                         410
                  ....*....|....*..
gi 488305844  404 VGVRISTFSVGPDRNQT 420
Cdd:pfam00709 400 LGVPIKIISVGPDREQT 416
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 3-420 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 733.52  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844     3 SVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKE 82
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844    83 LAYLKENNVA-TDNLRISDRAHVILPYHIKLDQLQEDAKgenkIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLK 161
Cdd:smart00788  81 IEELEAKGVDvKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   162 INLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSN 241
Cdd:smart00788 157 ELLDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   242 PVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVS 321
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   322 GITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRIS 401
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIE 396

                          410
                   ....*....|....*....
gi 488305844   402 ELVGVRISTFSVGPDRNQT 420
Cdd:smart00788 397 ELVGVPVSIISTGPDREQT 415
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 5-426 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 623.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844    5 VVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKELA 84
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   85 YLKENNVAT-DNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLKIN 163
Cdd:TIGR00184  81 YLEKRGISVrDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  164 LEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPV 243
Cdd:TIGR00184 161 LEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  244 AGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVSGI 323
Cdd:TIGR00184 241 AGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  324 TNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRISEL 403
Cdd:TIGR00184 321 TQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEEL 400

                         410       420
                  ....*....|....*....|...
gi 488305844  404 VGVRISTFSVGPDRNQTNVLESV 426
Cdd:TIGR00184 401 TGVPVTIISTGPEREQTIDLRKE 423
PLN02513 PLN02513
adenylosuccinate synthase
 1-420 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 521.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   1 MSSVVVV-GTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFD-GVTYKLHLIPSGIFYKEKISVIGNGVVVNPKS 78
Cdd:PLN02513   1 LSQVSAVlGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYNDeGKKFALHLVPSGILNEKTTCVIGNGVVVHLPG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  79 LVKELAYLKENNVATDN-LRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFA 157
Cdd:PLN02513  81 LFEEIDGLESNGVSCEGrLLVSDRAHLLFDFHQEVDGLREAELAGSKIGTTKRGIGPAYSSKATRNGLRVGDLRHMDTFA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 158 ERLKINLEEKNRQFvKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFV 237
Cdd:PLN02513 161 EKLRELLADAAARF-EGFEYDASMVEEEVEAYKKFAERLEPFITDTVHYLNEAIQAGKKILVEGAQATMLDIDFGTYPFV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 238 TSSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHS 317
Cdd:PLN02513 240 TSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVALKYS 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 318 KRVSGITNLSLNSIDVLSGLETVKICTAYEL-DGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNY 396
Cdd:PLN02513 320 CQINGFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAAAQAY 399

                        410       420
                 ....*....|....*....|....
gi 488305844 397 VHRISELVGVRISTFSVGPDRNQT 420
Cdd:PLN02513 400 VERIEELVGVPVHYIGVGPGRDAL 423
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 4-420 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 513.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   4 VVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKEL 83
Cdd:PTZ00350  15 VVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLEEI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  84 AYLKENNV-ATDNLRISDRAHVILPYHIKLDQLQEDAKGEN--KIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERL 160
Cdd:PTZ00350  95 EQLTKKGInLLGRLYISDRAHLVFDLHQAIDGIQESEKGKGgtQIGTTKRGIGPCYSTKASRTGLRVGDLLNFETFEKKY 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 161 KINLEEKNRQFVkmfdseaIEFDDIFEE---YYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFV 237
Cdd:PTZ00350 175 RKLVEKLQEQYN-------IEEYDAEEElerYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGTYPYV 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 238 TSSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHS 317
Cdd:PTZ00350 248 TSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYV 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 318 KRVSGITNLSLNSIDVLSGLETVKICTAYELDGE--LIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARN 395
Cdd:PTZ00350 328 QMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQK 407

                        410       420
                 ....*....|....*....|....*
gi 488305844 396 YVHRISELVGVRISTFSVGPDRNQT 420
Cdd:PTZ00350 408 YVLFIEELLGVPIVWIGVGPNRENM 432
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 2-420 1.19e-180

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 505.88  E-value: 1.19e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   2 SSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVK 81
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  82 ELAYLKENNVA-TDNLRISDRAHVILPYHIKLDQLQEDAKGENKIGTTIKGIGPAYMDKAARVGIRIADlldkeifaerl 160
Cdd:cd03108   81 EIEELEKKGIDvKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD----------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 161 kinleeknrqfvkmfdseaiefddifeeyyeygqqikQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSS 240
Cdd:cd03108  150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 241 NPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRV 320
Cdd:cd03108  193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 321 SGITNLSLNSIDVlsgletvkictayeldgeliyhypaslkelsrckpvyeelpgwseditgcktladlpaNARNYVHRI 400
Cdd:cd03108  273 NGLTELALTKLDV----------------------------------------------------------NAQKYIERI 294

                        410       420
                 ....*....|....*....|
gi 488305844 401 SELVGVRISTFSVGPDRNQT 420
Cdd:cd03108  295 EELLGVPITYISVGPDREQT 314
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 5-420 3.72e-163

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 465.81  E-value: 3.72e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   5 VVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKIsVIGNGVVVNPKSLVKELA 84
Cdd:PRK13786   4 IITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLDARV-LIGPGVVLNPEVLAEEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  85 YLKEN--NVATDNLRISDRAHVILPYHIKLDQLQEDAKGEnKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLKI 162
Cdd:PRK13786  83 MLEKHgvKVDAEKLGIDAKTSIIMPYHIELDGLRESARTE-KIGTTKRGIGFAYIDKIARDEVRMSDLVDKERLMRRLEE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 163 NLEEKNRQFVKMFDSEAIEFDD-IFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTSSN 241
Cdd:PRK13786 162 LAPQKEKEIKELGGDPSIVRDEaLIDKYLELGRQLAPYITDVSYEINKALDEGKSVLAEGAQGTHLDVIHGTQKFVTSSS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 242 PVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVS 321
Cdd:PRK13786 242 TIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIYLN 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 322 GITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVHRIS 401
Cdd:PRK13786 322 GYTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVERLE 401

                        410
                 ....*....|....*....
gi 488305844 402 ELVGVRISTFSVGPDRNQT 420
Cdd:PRK13786 402 ELMGVPIKYISVGPGREQT 420
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 1-420 6.82e-154

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 442.47  E-value: 6.82e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   1 MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLV 80
Cdd:PRK13787   1 MPASLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  81 KELAYL-KENNVATDNLRISDRAHVILPYHIKLDQLQEDAKG-ENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEiFAE 158
Cdd:PRK13787  81 EECDRLqKEGFPVKDKLLLSDACHLLFPYHSQIDSARETTSSqEHKIGTTKKGIGICYADKMMRTGLRVGDLLDKS-YKR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 159 RLKINLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVT 238
Cdd:PRK13787 160 RLKHLVDEKNRELDKLYGMPPVSYNDINDGLKFFLSKVGKNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYVT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 239 SSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSK 318
Cdd:PRK13787 240 SSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHSV 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 319 RVSGITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPAslKELSRCKPVYEELPGWSEDITGCKTLADLPANARNYVH 398
Cdd:PRK13787 320 RINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYIS 397

                        410       420
                 ....*....|....*....|..
gi 488305844 399 RISELVGVRISTFSVGPDRNQT 420
Cdd:PRK13787 398 ALEKWIGVKINLVSTGPDRKDT 419
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 3-425 7.12e-151

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 435.73  E-value: 7.12e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   3 SVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFyKEKISVIGNGVVVNPKSLVKE 82
Cdd:PRK13785   2 TVTIVGSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAV-RGKIGVLGNGCVVNPETLFDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  83 LAYLKENNVATDnLRISDRAHVILPYHIKLDQLQEDAKGEN--KIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERL 160
Cdd:PRK13785  81 IDALRERGLDPD-VRVAERAHVILPYHRVLDGIEEEAKSDSdlEVGTTGRGIGPTYEDKAGRRGVRVGDLLDPDVLRDRL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 161 KINLEEKNRQFVKMFD------SEAIEFDDIFEEYYEYGQQIKQ--YVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQG 232
Cdd:PRK13785 160 EYVVPQKRALAEDVYGldasetPEAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDDGDNVMLEGAQGTSIDIDHG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 233 TYPFVTSSNPVAGGVTIGSGVGPSKINK--VVGVCKAYTSRVGDGPFPTELFDETGET---------------IRRVGKE 295
Cdd:PRK13785 240 NYPYVTSSNPTAGGAATGTGLGPTVVGQgeVVGIVKAYLSRVGSGPLPTELGGVEGDTpdeggrpdeeelatyIREEGGE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 296 YGTTTGRPRRVGWFDSVVMRHSKRVSGITNLSLNSIDVLSGLETVKICTAYELDGELIYHYPASLKELSRCKPVYEELPG 375
Cdd:PRK13785 320 YGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPNFRSFDG 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 488305844 376 WSEdiTGCKTLAD-----LPANARNYVHRISELVGVRISTFSVGPDRNQTNVLES 425
Cdd:PRK13785 400 WPE--VDWAAVAEegydaLPENARTYLEYVSDELDTPIYAVGVGPGREETVVLEN 452
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 1-420 6.64e-148

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 426.14  E-value: 6.64e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   1 MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLV 80
Cdd:PRK13788   1 MPGIAIIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  81 KELAYLKENNVaTDNLRISDRAHVILPYHIKLDQlqedakGENKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERL 160
Cdd:PRK13788  81 EERENLRAGGL-NPKLLISERAHLVLPHHKYVDG------RKNFVGTTGRGIGPAYSDRARRVGIRFGDLLDEAVLRERV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 161 KINLEEK-NRQFVKMFDSEaiefDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVTS 239
Cdd:PRK13788 154 ERLLEAKpNSTREAGWDTV----EKALADLAPMREILLPFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYPYVTS 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 240 SNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVG----KEYGTTTGRPRRVGWFDSVVMR 315
Cdd:PRK13788 230 SHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLK 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 316 HSKRVSGITNLSLNSIDVLSGLETVKICTAYELDGeliyhypaslkelsrcKPVYEELPGWSeDITGCKTLADLPANARN 395
Cdd:PRK13788 310 YACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDG----------------QPVYKELPGWG-DLDGVKSREALPKEAQA 372

                        410       420
                 ....*....|....*....|....*
gi 488305844 396 YVHRISELVGVRISTFSVGPDRNQT 420
Cdd:PRK13788 373 YLELIEETTGVPVVMFSTSPRREDT 397
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 5-415 5.07e-140

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 406.41  E-value: 5.07e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   5 VVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLVKELA 84
Cdd:PRK13783   4 VIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVEELE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  85 YLKEN-NVATDNLRISDRAHVILPYHIKLDQLQEDAKGeNKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAERLKIN 163
Cdd:PRK13783  84 ELKEKfPDYSGRIFISELAHVVLPVHKELDEIIESVRK-NAIGTTKRGIGPAYADKVMRVGVRLADLFDEEKLREFLEKI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 164 LEEKNRQFVKMFDSEAIeFDDIFEEYyeygQQIKQYVTDTSVILNdaLDAGKRVLFEGAQGVMLDIDQGTYPFVTSSNPV 243
Cdd:PRK13783 163 LSLYKKLYGIEFDVEKM-MEDLLTFY----EKIKDLVVSPVEIKR--ILEEKSVLFEGTQGVLLDLDVGTYPYVTSSNCS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 244 AGGVTIGSGVgPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSKRVSGI 323
Cdd:PRK13783 236 TTGVSAGMGF-PVKVDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEVSGV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 324 TNLSLNSIDVLSGLETVKICTAYELDGElIYHYPASLKELSRCKPVYEELPGWseditgcKTLADlpANARNYVHRISEL 403
Cdd:PRK13783 315 DSLVMTKADVLNGFEKIKVCVRYEIGGK-EVRDPSSLRDLEKAEPVYEEFDGW-------KSLED--KNFLKFVDFIERE 384

                        410
                 ....*....|..
gi 488305844 404 VGVRISTFSVGP 415
Cdd:PRK13783 385 TGRKIAYISTGP 396
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 1-424 1.71e-121

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 360.10  E-value: 1.71e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   1 MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSLV 80
Cdd:PRK13784   1 MSNIVIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  81 KELAYLKENNVA--TDNLRISDRAHVILPYHIKLDQLQEDAKGEnKIGTTIKGIGPAYMDKAARVGIRIADLLDKEIFAE 158
Cdd:PRK13784  81 EEITRLQAKGIAisAENLFVSESCTIITSYHKLLDAVRESNTSE-KIGTTGKGIGPAYEDKVSRKGIKFKHLFDKDLLRS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 159 RLKINLEEKNRQFVKMFDSEAIEFDDIFEEYYEYGQQIKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVT 238
Cdd:PRK13784 160 RLAISLAEKETLFRDLYKVEYPTLEQEFDKLFALGQKLKQYAADTFSIIDQAIAAGKNVVYEGAQGVLLDVDYGTYPFVT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 239 SSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDETGETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSK 318
Cdd:PRK13784 240 SSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSA 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 319 RVSGITNLSLNSIDVLSGLETVKICTAYELDGELIY-HYPASlkELSRCKPVYEELPGWSEDITGCKTlaDLPANARNYV 397
Cdd:PRK13784 320 KCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIYcAYPGI--DLYKVEPILVEMEPFSIDETVTKD--NMPAALKTYL 395

                        410       420
                 ....*....|....*....|....*..
gi 488305844 398 HRISELVGVRISTFSVGPDRNQTNVLE 424
Cdd:PRK13784 396 KTIENHVGIPISSLAYGPSREQILFFE 422
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 1-420 8.83e-81

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 252.11  E-value: 8.83e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   1 MSSVVVVGTQWGDEGKGKITDFLS--ENAEVIARYQGGDNAGHTIKFDGVTYKLHLIPSGIFYKEKISVIGNGVVVNPKS 78
Cdd:PRK04293   1 MTCTIVVGGFFGDEGKGKIIAYLAlkDKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  79 LVKELAYLKennvATDNLRISDRAHVILPYHIKLDQlqEDAKGENKIGTTIKGIGPAYMDKAARvgiriadlldkeifae 158
Cdd:PRK04293  81 LLKEVEELN----VGGRVFVDYRCGIIEEKHVEEDR--SDEHLSKKIGSTGTGCGPANADRVLR---------------- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 159 RLKInleeknrqfvkmfdseAIEFDDIfeeyyeygqqiKQYVTDTSVILNDALDAGKRVLFEGAQGVMLDIDQGTYPFVT 238
Cdd:PRK04293 139 RLKL----------------AKDVEEL-----------EKYLTDVPEEVNEALDRGENVLIEGTQGFGLSLYYGTYPYVT 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 239 SSNPVAGGVTIGSGVGPSKINKVVGVCKAYTSRVGDGPFPTELFDEtgETIRRVGKEYGTTTGRPRRVGWFDSVVMRHSK 318
Cdd:PRK04293 192 SKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLE--EAEKLGLVEYGTVTGRRRRVGPFDFELARRAA 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 319 RVSGITNLSLNSIDVLsgletvkictayeldgeliyhYPaslkelsrckpvyeelpgwseDITGCKTLADLPANARNYVH 398
Cdd:PRK04293 270 RINGATQIAITKLDKL---------------------DK---------------------EAYGVTEYDKLPPEAKKFIE 307

                        410       420
                 ....*....|....*....|..
gi 488305844 399 RISELVGVRISTFSVGPDRNQT 420
Cdd:PRK04293 308 EIEEELGVPVTLISTGPELEDT 329
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
5-322 3.02e-34

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 129.41  E-value: 3.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   5 VVVGTQWGDEGKGKITDFLSENAEVIARYQ-GGDNAGHT-IKFDGVTYKLHLIPSGIFY-KEKISVIGNGVVVNPKSLVK 81
Cdd:NF038379   3 VVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTyIDDEGRKFVHRMLPNGIVSpPLKQVLIGPGSEIDLEVLRE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  82 ELAYLKEN-NVATDNLRISDRAHVILPYHikldQLQEDAKGENKIGTTIKGIGPAYMDK----AARVGIRIADLLDKEIf 156
Cdd:NF038379  83 EIEELEDAgHDVGKRLLIHEQATVIELHK----HVEEEAGPMTKIGSTKKGIGAARAAKirrnPSTLGDAEGDFGEGAV- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 157 aerlkinleeknrqfvkmfDSEAIEFDDIFEEYYEYGQqikqyvtdtsvilndALDAGKRVLFEGAQGVMLDIDQGTYPF 236
Cdd:NF038379 158 -------------------RDQPWEIAERVVDNALYDF---------------ALQAAERIQIEGTQGYSLGLHAGFYPY 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 237 VTSSNPVAGGVTIGSGVGPS--KINKVVGVCKAYTSRVGD-----GPFPTEL-FDETGetirrVGKEYGTTTGRPRRVGW 308
Cdd:NF038379 204 CTSRDCTPADFLADAGIPLPnvDAFKVVGTARTYPIRVAGwsgnsYPDQGETtWEELG-----LPEELTTVTKKVRRVGT 278

                        330
                 ....*....|....
gi 488305844 309 FDSVVMRHSKRVSG 322
Cdd:NF038379 279 FSAEQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 4-281 2.91e-16

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 81.25  E-value: 2.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844   4 VVVVGTQWGDEGKGKITDFLSEN--AEVIARYQGGDNAGHTIkFD--GVTYKLHLIPSGIFYKEKISVIGNGVVVNPKSL 79
Cdd:PTZ00351 172 IMVAGAFFGDEGKGKTVDAVAHHplCTCIARVNSGENAGHTV-YDkaGRKFVFNLAPSGLLLPGKRNYIGPECVMDPVSF 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844  80 V-KELAYLKENNVATDNLRISDRAHVILPYHIKLDQLQEDAKgenkiGTTIKGIGPAYMDKAARVGIRIADLL-DKEIFA 157
Cdd:PTZ00351 251 MeKEIIQLIDAGIDYRDRLFIGNVCIVTPYHKLLDLLGSAAN-----SSTLKGMAPVHGSKVMKRGIRLDHIFnDDETLR 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 488305844 158 ERLKINLE---------------------EKNRQFVKMFDSEAIEFDDIFEE-------YYEYGQQIKQYVTDTSVI--L 207
Cdd:PTZ00351 326 KRLEKDMDtylgllkvknlsdadvvrlcrEENSDGVVRVPDYVIAFAQAKDKveflvklYRDRVRHNPDFPARCDVTyeL 405

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 488305844 208 NDALDAGKRVLFEGAQGVMLDIDQGTY-PFVTSSNPVAGGVTIGSGVGPSKINKVV-GVCKAY-TSRVGDGPFPTEL 281
Cdd:PTZ00351 406 HAAVLRGEKVLLEGPQSYWLSNARTKFwESTTSADTTAAGLLAASQLNFQKFKSVVlNVHKAPgSSRVGIGACPSSF 482
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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